Education

Biography

Research Interest

• Gastroenterology
• Colonic carcinogenesis
• Regulation of cyclooxygenase-2 (cox-2) gene expression by bile acids
• Primary biliary cirrhosis (PBC) 
• The regulation of Sprouty protein in colon cancer

SCIENTIFIC ACTIVITY

Society Memberships

• 2003-American Gastroenterological Association

Publications

1. Qiong Zhang, Tao Wei, Kan Xu, Kevin Wright, Alexander Jurkevich, Katherine Shim and Sharad Khare. Atypical role of Sprouty2 in colorectal cancer: Sprouty repression inhibits epithelial-mesenchymal transition. Oncogene (Advance online publication 5 October 2015; doi: 10.1038/onc.2015.365),(Impact Factor-8.7) (Rank # 5 out of 194 cancer research journals)
2. Qiong Zhang, Katherine Shim, Kevin Wright, Alexander Jurkevich and Sharad Khare Atypical role of Sprouty in p21 dependent inhibition of cell proliferation in colorectal cancer, Molecular Carcinogenesis (August 21, 2015doi: 10.1002/mc.22379 Epub ahead of print) (Impact Factor-4.8) (Rank # 51 out of 194 cancer research journals)
3. Vivek Vaish, Tripti Khare, MukeshVerma and Sharad Khare Epigenetic therapy for colorectal cancer Methods in Molecular Biology Cancer Epigenetics,Vol. 1238, DOI 10.1007/978-1-4939-1804-1_40, 2015 (Impact Factor-1.3) (Rank # 23 out of 214 biochemistry, genetics and molecular biology miscellaneous journals)
4. Urszula Dougherty, Reba Mustafi, FarhanaSadiq, AnasAlmoghrabi, DevkumarMustafi, Maggi Kreisheh, SumanaSundaramurthy, Weicheng Liu, Vani J Konda, Joel Pekow, Sharad Khare, John Hart, Loren Joseph, aliceWyrwicz, Gregory S. Karczmar, Yan Chun Li and Marc Bissonnette. The renin-angiotensin system mediates epidermal growth factor receptor-vitamin D receptor cross-talk in colitis-associated colon cancerClinical Cancer Research,20 (22); 5848-5859, 2014. (Impact Factor-8.2) (Rank # 6 out of cancer research 194 journals)
5. Tripti Khare and Sharad Khare Controversies in chemoprevention of colorectal cancer with ursodeoxycholic acid JSM Gastroenterology and Hepatology, 2 (1); 1-4, 2014 (An On-line ResearchCommunication)
6. Khare S, Zhang Q, Ibdah JA. Epigenetics of hepatocellular carcinoma: Role of microRNA. World Clinical Gastroenterology (1st ed). Ma L, Chua MS, So S (eds) 2014 (ISBN 978-0-9914430-0-0), 2014. (Book Chapter)
7. Sharad Khare, Qiong Zhang and Jamal A Ibdah,Epigenetics of hepatocellular carcinoma: Role of microRNA. World Journal of Gastroenterology 19 (33): 5439–5445, 2013.(Impact Factor-2.5) (Rank # 13 out of 132 gastroenterology journals)
8. Qiong Zhang, MukeshVerma and Sharad Khare Epigenetic regulation of microRNA in colon cancerEpigenetics and Cancer DOI 10.1007/978-94-007-6612-9_5, 2013 (Book Chapter)
9. Sharad Khare and MukeshVerma. Epigenetics of colon cancer, Methods in Molecular Biology, Cancer Epigenetics, Vol. 863, 10: 177-185, 2012.(Impact Factor-1.3) (Rank # 23 out of 214 biochemistry, genetics and molecular biology miscellaneous journals)
10. Cory Holgren,Urszula Dougherty, Francis Edwin, DairoCerasi, Ieva Taylor,Loren Joseph, Alessandro Fichera, Marc Bissonnette, and Sharad Khare. Sprouty-2 Controls c-Met expression and metastatic potential of colon cancer cells: Sprouty/c-Met up-regulation in human colonic adenocarcinomas. Oncogene, 29: 5241-5253, 2010.(Impact Factor-8.7) (Rank # 5 out of 194 cancer research journals)
11. Sharad Khare,Kamran Chaudhary, Marc Bissonnette, and Robert Carroll, Aberrant crypt foci in colon cancer epidemiology,Methods of Molecular Biology, Cancer Epidemiology, Vol. 472, 17: 373-386, 2009. (Impact Factor-1.3) (Rank # 23 out of 214 biochemistry, genetics and molecular biology miscellaneous journals)
12. Sharad Khare, Reba Mustafi, Sonia Cerda, Weihua Yuan, Sujatha Jagadeeswaran, Urszula Dougherty, Maria Tretiakova, Allen Samarel, Greg Cohen, Julia Wang, Christopher Moore, Ramesh Wali, Cory Holgren, and Cory Holgren, Loren Joseph, Alessandro Fichera, Yan Chun Li, and Marc Bissonnette. Ursodeoxycholic acid suppresses Cox-2 expression in colon cancer: Roles of Ras, p38 and CCAAT/enhancer-binding protein. Nutrition and Cancer, 60(3): 389-400, 2008.(Impact Factor-2.6)
13. Alessandro Fichera, Nathaniel Little, Sonia Cerda, Sujatha Jagadeeswaran, Sharad Khare, Maria Tretiakova, Can Gong, Greg Cohen, Loren Joseph, John Hart, Jerry Turner and Marc Bissonnette. Epidermal growth factor receptor signaling is required for microadenoma formation in the mouse azoxymethane model of colonic carcinogenesis. Cancer Research, 67(2): 827-35, 2007. (Impact Factor-9.3) (Rank # 2 out of 194 cancer research journals)
14. Khare, S.,Mustafi, R., Cerda, S., Fichera, A., and Bissonnette, M. Differential signaling pathways of tumor-promoting and tumor-inhibiting bile acids in colonic carcinogenesis. Highlights in Gastrointestinal Oncology, 13: 1-17, 2006. (Book Chapter)
15. Sharad Khare, Cory Holgren, and Allen M. SamarelDeoxycholic acid differentially regulates focal adhesion kinase phosphorylation: Role of tyrosine phosphatase ShP2. Am. J. Physiol. Gastrointestinal and Liver Physiology, 291(6): G1100-G1112, 2006(Impact Factor-3.7) (Rank # 5 out of 132 gastroenterology journals)
16. Greg Cohen, Nathaniel Little, Reba Mustafi, Piotr Obara, Loren Joseph, John Hart, Lisa Yerian, Maria Tretiakova, Sharad Khare, Frank A. Sinicrope, Alessandro Fichera, Gerry R. Boss, Robert Carroll and Marc Bissonnette. Epidermal growth factor receptor signaling is up-regulated in human colonic aberrant crypt foci. Cancer Research, 66: 5456-5464, 2006. (Impact Factor-9.3) (Rank # 2 out of cancer research 194 journals)
17. Sonia R. Cerda, Reba Mustafi, Holly Little, Greg Cohen, Christopher Moore, Sharad Khare, and Marc Bissonnette. Protein kinase-c delta inhibits cell proliferation in Caco-2 cells by selective cell cycle and cell death regulators. Oncogene, 25, 3123-3138, 2006,(Impact Factor-8.7) (Rank # 5 out of 194 cancer research journals)
18. Khare, S., Cerda, S, Wali, R., von Lintig, F.C. Tretiakova, M., Stobier, D., Cohen, G., Nimmagadda, K., Hart, J., Sitrin, M.D., Boss, G.R. Bissonnette, M. Ursodeoxycholic acid inhibits Ras mutations and wild type Ras activation and Cox-2 expression in colon cancer. Cancer Research 63: 3517-3523, 2003. (Impact Factor-9.3) (Rank # 2 out of 194 cancer research journals)
19. Cohen G, Khare S,Tretiakova M, Carroll R, Bissonnette M. COX-2 and iNOS expression in aberrant crypt foci from human colons.International Journal of Biological Markers,17(S2): 23-24, 2002.(Impact Factor-1.4) (Rank # 23 out of 214 biochemistry, genetics and molecular biology miscellaneous journals)
20. Wali, R.K., Khare, S.,Tretiakova, M., Cohen, G., Nguyen, Lan, Hart, J., Wang, J., Bissonnette, M. Ursodeoxycholic acid and F6-D3 inhibits aberrant Crypt proliferation in the rat Azoxymethane model of colon cancer: Roles of Cyclin D1 and E-cadherin.Cancer Epidemiology Biomarkers and Prevention, 11: 1653-1662, 2002, (Impact Factor-4.3) (Rank # 4 out of 86 epidemiology journals)
21. Cerda, S, R., Bissonnette, M., Scaglione-Sewell, B., Matthew R. L., Khare, S.,Mustafi, R., Brasitus, T. A. PKC- inhibits anchorage-dependent and-independent growth, enhances differentiation, and increases apoptosis in Caco-2 cells.Gastroenterology, 120: 1700-1712, 2001, (Impact Factor-12.9) (Rank # 1 out of 132 gastroenterology journals)
22. Bissonnette, M., *Khare, S., von Lintig, F.C., Wali, R.K., Hart, J., Nguyen, L., Zhang, Y., Hart, J., Skarosi, S., Varki, N., Boss, G.R. and Brasitus, T.A.  Mutational and non-mutational activation of p21ras in rat colonic azoxymethane-induced tumors: Effects on MAPK, Cox-2 and cyclin D1. Cancer Research, 4602-4609, 2000, * Equal Contribution (Impact Factor-9.3) (Rank # 2 out of 194 cancer research journals)
23. Sitrin, M.D., Bissonnette, M., Bolt, M.J.G., Wali, R., Khare, S., Scaglione-Sewell, B., Skarosi, S. and Brasitus, T.A. Rapid effects at 1,25(OH)2 vitamin D3 on signal transduction systems in colonic cells.  Steroids, 64:137-142, 1999(Impact Factor-2.8) (Rank # 28 out of 121 endocrinology journals)
24. Khare, S., Bissonnette, M., Wali, R.K., Lintig, F.C., Scaglione-Sewell, B., Sitrin, M.D. and Brasitus, T.A. 1,25-dihydroxyvitamin D3, but not TPA activates PLD in CaCo-2 cells via pp60 c-src and RhoA. Am. J. Physiol. Gastrointestinal and Liver Physiology, 276: G1005-G1015, 1999 (Impact Factor-3.7) (Rank # 5 out of 132 gastroenterology journals)
25. Khare, S., Bissonnette, M., Scaglione-Sewell, B., Wali, R.K., Sitrin, M.D. and Brasitus, T.A. 1,25-dihydroxyvitamin D3 and TPA activate phospholipase D in CaCo-2 cells: Role of PKC-. Am. J. Physiol. Gastrointestinal and Liver Physiology, 276: G993-G1004, 1999 (Impact Factor-3.7) (Rank # 5 out of 132 gastroenterology journals)
26. Wali, R.K., Bissonnette, M, Skarosi, S., Khare, S.,Sitrin, M.D. and Brasitus, T.A. 1,25dihydroxyvitamin D3 targets PKC-2 but not PKC-to the basolateral plasma membranes of rat colonocytes. Biochem.Biophys. Res. Comm. 250: 48-52, 1998.(Impact Factor-2.5) (Rank # 2 out of 123 biophysics journals)
27. Khare, S., Bolt, M., Wali, R.K., Roy, H K., Niedziela, S., Scaglione-Sewell, B.A., Aquino, B., Sitrin, M.D., Brasitus, T.A. and Bissonnette, M. 1,25dihydroxyvitamin D3 stimulates phospholipase- in rat colonocytes: Role of c-Src in PLC- activation. Journal of Clinical Investigation, 99: 1831-1841, 1997.(Impact Factor-13.7) (Rank # 6 out of 1827 medicine journals)
28. Wali, R.K. Bissonnette, M., Khare S.,Sitrin, M. and Brasitus, T.A. Protein kinase C isoforms in the chemopreventive effects of a novel vitamin D3 analogue in rat colonic tumorigenesis. Gastroenterology, 111:118-126, 1996.(Impact Factor-14) (Rank # 1 out of 132 gastroenterology journals)
29. Wali, R.K., Frawley, B P., Jr., Hartmann, S., Roy, H.K., Khare, S., Scaglione-Sewell, B.A., Earnest, D.L., Sitrin, M.D., Brasitus, T.A. and Bissonnette, M.  Mechanism of action of chemoprotectiveursodeoxycholate in the azoxymethane model of rat colonic carcinogenesis: potential role of PKC-, 2 and . Cancer Research, 55: 5257-5264, 1995. (Impact Factor-9.3) (Rank # 2 out of 194 cancer research journals)
30. Wali, R.K., Bissonnette, B.M., Khare, S., Hart, J., Sitrin, M. D. and Brasitus, T.A. 1,25-dihydroxy-16-ene-23-yne-26, 27-hexafluorocholecalciferol, a non-calcemic analogue of 1,25-dihydroxyvitamin inhibits azoxymethane-induced colonic tumorigenesis. Cancer Research, 55: 3050-3054, 1995. (Impact Factor-9.3) (Rank # 2 out of 194 cancer research journals)
31. Wali, R.K., Bissonnette, B.M., Jiang, K., Niedziela, S.M., Khare, S., Roy, H.K., Sitrin, M.D. and Brasitus, T.A. 1,25-dihydroxyvitamin D3 stimulates the phosphorylation of two acidic membrane proteins of 42,000 and 48,000 daltons in rat colonocytes: an effect modulated by vitamin D status. Journal of Cellular Physiology, 162:172-180, 1995.(Impact Factor-3.9) (Rank # 21 out of 178 physiology journals)
32. Earnest, D.L., Holubec, H., Wali, R.K., Jolley, C.S., Bissonnette, B.M., Bhattacharya, A.K., Roy, H., Khare, S. and Brasitus, T.A. Chemoprevention of azoxymethane-induced colonic carcinogenesis by supplemental dietary ursodeoxycholic acid. Cancer Research, 54:5071-5074, 1994.(Impact Factor-9.3) (Rank # 2 out of 194cancer research journals)
33. Khare, S., Wilson, D., Wali, R., Tien, X.Y., Bissonnette, B.M., Niedziela, S.M., Bolt, M.J.G., Sitrin, M.D. and Brasitus, T.A.  Guanylin activates rat colonic particulate guanylate cyclase. Biochemical and Biophysical Research Communications, 203:1432-1437, 1994. (Impact Factor-2.5) (Rank # 2 out of 123 biophysics journals)
34. Khare, S., Wilson, D.M., Tien, XY, Bissonnette, B.M. and Brasitus, T.A.  Protein kinase C mediates the calcium-induced activation of rat colonic particulate guanylate cyclase. Archives of Biochemistry and Biophysics, 314: 200-204, 1994. (Impact Factor-4.6) (Rank # 7 out of 123 biophysics journals)
35. Khare, S., Tien, X.Y., Wilson, D., Wali, R.K., Bissonnette, B.M., Sitrin, M.D. and Brasitus, T.A. Vitamin D status modulates rat colonic M3 muscarinic receptor characteristics and coupling to guanylate cyclase. FEBS Letters, 347: 27-30, 1994.(Impact Factor-3.5)(Rank # 3 out of 123 biophysics journals)
36. Khare, S., Tien, XY, Wilson, D. M., Wali, R.K., Bissonnette, B M., Scaglione Sewell, B., Sitrin, M.D. and Brasitus, T.A. The role of PKC- in the activation of particulate guanylate cyclase by 1,25-dihydroxyvitamin D3 in Caco-2 cells. Endocrinology, 135: 277-283, 1994. (Impact Factor-4.5) (Rank # 3 out of 121 endocrinology journals)
37. Khare, S., Wilson, D.M., Tien, XY, Dudeja, P.K., Wali, R.K., Sitrin, M.D. and Brasitus, T.A. 1,25dihydroxycholecalciferol rapidly activates rat colonic particulate guanylate cyclase via a protein kinase C dependent mechanism. Endocrinology, 133:2213-2219, 1993. (Impact Factor-4.5) (Rank # 3 out of 121 endocrinology journals)
38. Khare, S., Wilson, D.M., Tien, XY and Brasitus, T.A. M3 muscarinic receptors on rat colonocytes are coupled to particulate guanylate cyclase activation. BiochimicaBiophysicaActa, 1179:234-237, 1993.(Impact Factor-4.6) (Rank # 14 out of 123 biophysics journals)
39. Khare, S. and Ghatak, S. Cyclic AMP level of plasmodium berghei infected red cells of Mastomysnatalensis. Experientia, 47:236-237, 1991.
40. Saxena, J.K., Khare, S., Srivastava, A.K., Sen, A.B. and Ghatak, S.  Hepatic acid hydrolases of albino rats, Mastomysnatalensis and albino mice during plasmodium berghei infection,Experientia, 41:472-474, 1985.
41. Khare, S., Saxena, J.K., Sen, A.B. and Ghatak, S.  Erythrocyte membrane bound enzymes in Mastomysnatalensis during plasmodium berghei infection. Australian Journal of Experimental Biology and Medical Science, 62:137-143, 1984.
42. Saxena, J.K., Khare, S., Srivastava, A.K., Sen, A.B. and Ghatak, S.  Lysosomal enzymes in spleen of albino rats, mice and Mastomysnatalensis during plasmodium berghei infection Australian Journal of Experimental Biology and Medical Science, 61:637-640, 1983.
43. Khare, S., Srivastava, V.M.L., Ghatak, S., Chandra, S. and Sen, A.B.  Effects of chloroquine in vivo on the cyclic AMP level of erythrocytes from normal and plasmodium berghei infected Mastomysnatalensis. Indian Journal of Malariology, 19:123-126, 1982.
44. Khare, S.,Ghatak, S., Chandra, S. and Sen, A.B.  Plasmodium berghei-regulatory effects of spleen sonicate on the uptake of glucose in vitro by the erythrocytes of albino rats and Mastomysnatalensis.  Indian Journal of Malariology, 19:39-44, 1982.