Francesca Diomede, DDS, PhD
Department of Medical, Oral and Biotechnological Sciences

University G. d'Annunzio
Chieti and Pescara, Italy
Phone: +39.3892496423


2015 PhD in Applied and Basic Maedical Sciences University “G. d’Annunzio”, Chieti-Pescara
2012 Board in Dentistry  
110/110 cum laude, 2012 Doctor in Dental Surgery University “G. d’Annunzio”, Chieti-Pescara



Research Interest

  • Study of molecular mechanisms and applied basic sciences to translation for human health.
  • Mechanisms that regulate and leading the stem cells activity on tissue homeostasis and repair throughout the identification of intracellular pathway that regulate the regenerative potential.
  • Regenerative medicine includes the stem cells differentiation, 3D scaffold evaluation, the design of novel living constructs and new approaches towards tissue regeneration and the use of stem cells in cell therapy.
  • Self-renew ability and lineage selection by human mesenchymal stem cells from oral tissues.
  • Stem cells modeling to use in neurodegenerative disorders.

Scientific Activities

  • Group and Association:
  • Stem Tech Group, Università degli Studi “G. d’Annunzio”, Chieti-Pescara.
  • TERMIS - Tissue Engineering International and Regenerative Medicine Society.
  • TCES - Tissue and Cell Engineering Society.
  • SFB - Society for Biomaterials.
Scientific Awards
  • Diomede F, Pizzicannella J, Sinjari B, Merciaro I, Caputi S, Trubiani O. Periodontal vs Cardiovascular Diseases and Stem Cells: an Intriguing Correlation. XXIV Congresso Nazionale del Collegio dei Docenti di Odontoiatria, Rome, Italy, 6-8 April 2017.
  • Cover Image, Volume 118, Number 6, June 2017. Soundara Rajan T, Giacoppo S, Scionti D, Diomede F, Grassi G, Pollastro F, Piattelli A, Bramanti P, Mazzon E, Trubiani O. J Cell Biochem 118(6):i. doi: 10.1002/jcb.25699 (2017).
  • Diomede F, Pizzicannella J, Merciaro I, Guarnieri S, Trubiani O. An intriguing relation between periodontal and cardiovascular diseases. 70th Italian society of Histology and Anatomy Annual Meeting, Rome, Italy, 15-17 September 2016.
  • Diomede F, Merciaro I, Pizzicannella J, Caputi S, Trubiani O. Xeno-free culture of human periodontal ligament stem cells: a novel platform for tissue engineering. XXI Congresso Nazionale del Collegio dei Docenti di Odontoiatria, Rome, Italy, 10-12 April 2014.


  1. Ballerini P, Diomede F, Petragnani N, Cicchitti S, Merciaro I, Cavalcanti MFXB, Trubiani O. Conditioned medium from relapsing-remitting multiple sclerosis patients reduces the expression and release of inflammatory cytokines induced by LPS-gingivalis in THP-1 and MO3.13 cell lines. Cytokine. 96:261-272. doi: 10.1016/j.cyto.2017.04.022. (2017).
  2. Giacoppo S, Thangavelu SR, Diomede F, Bramanti P, Conti P, Trubiani O, Mazzon E Anti-inflammatory effects of hypoxic-preconditioned human periodontal ligament cells secretome in an experimental model of multiple sclerosis: a key role of IL-37.. FASEB J. pii: fj.201700524R. doi: 10.1096/fj.201700524R. [Epub ahead of print]
  3. Soundara Rajan T, Giacoppo S, Diomede F, Bramanti P, Trubiani O, Mazzon E. Human periodontal ligament stem cells secretome from multiple sclerosis patients suppresses NALP3 inflammasome activation in experimental autoimmune encephalomyelitis. Int J Immunopathol Pharmacol. 2017 1:394632017722332. doi: 10.1177/0394632017722332. [Epub ahead of print]
  4. Diomede F, Zingariello M, Cavalcanti MFXB, Merciaro I, Pizzicannella J, De Isla N, Caputi S, Ballerini P, Trubiani O. MyD88/ERK/NFkB pathways and pro-inflammatory cytokines release in periodontal ligament stem cells stimulated by Porphyromonas gingivalis. European Journal of Histochemistry 61:2791, 122-127.
  5.                Gugliandolo A, Soundara Rajan T, Scionti D, Diomede F, Bramanti P, Mazzon E, Trubiani O. Reprogramming of Oncogene Expression in Gingival Mesenchymal Stem Cells Following Long-Term Culture In Vitro. Cell Reprogram. doi: 10.1089/cell.2016.0056. (2017).
  6.                Diomede F, Rajan TS, Gatta V, D'Aurora M, Merciaro I, Marchisio M, Muttini A, Caputi S, Bramanti P, Mazzon E, Trubiani O. Stemness Maintenance Properties in Human Oral Stem Cells after Long-Term Passage. Stem Cells Int. 2017;2017:5651287. doi: 10.1155/2017/5651287. (2017).
  7. Soundara Rajan T, Giacoppo S, Scionti D, Diomede F, Grassi G, Pollastro F, Piattelli A, Bramanti P, Mazzon E, Trubiani O. Cover Image, Volume 118, Number 6, June 2017. Journal of Cellullar Biochemestry; 118(6):i. doi: 10.1002/jcb.25699 (2017).
  8. Mazzoni S, Mohammadi S, Tromba G, Diomede F, Piattelli A, Trubiani O, Giuliani A. Role of Cortico-Cancellous Heterologous Bone in Human Periodontal Ligament Stem Cell Xeno-Free Culture Studied by Synchrotron Radiation Phase-Contrast Microtomography. International Journal of Molecular Sciences; 18(2) pii: E364 (2017).
  9. Libro R, Diomede F, Scionti D, Piattelli A, Grassi G, Pollastro F, Bramanti P, Mazzon E, Trubiani O. Cannabidiol Modulates the Expression of Alzheimer's Disease-Related Genes in Mesenchymal Stem Cells. International Journal of Molecular Sciences; 18(1) pii: E26 (2016).
  10. Rajan TS, Giacoppo S, Diomede F, Ballerini P, Paolantonio M, Marchisio M, Piattelli A, Bramanti P, Mazzon E, Trubiani O. The secretome of periodontal ligament stem cells from MS patients protects against EAE. Scientific Reports 6:38743 (2016).
  11. Rajan TS, Giacoppo S, Scionti D, Diomede F, Grassi G, Pollastro F, Piattelli A, Bramanti P, Mazzon E, Trubiani O. Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. Journal of Cellullar Biochemestry; 118(6):1531-1546 (2017).
  12. Libro R, Scionti D, Diomede F, Marchisio M, Grassi G, Pollastro F, Piattelli A, Bramanti P, Mazzon E, Trubiani O. Cannabidiol modulates the immunophenotype and inhibits the activation of the inflammasome in human gingival mesenchymal stem cells. Frontiers in Physiology; 7:559 (2016).
  13. Diomede F, Merciaro I, Martinotti S, Cavalcanti MFXB, Caputi S, Mazzon E, Trubiani O. MiR-2861 is involved in osteogenic commitment of human Periodontal Ligament Stem Cells grown onto 3D scaffold. Journal Biological Regulators and Homeostatic Agents; 30(4):1009-1018 (2016).
  14. Rajan TS, Giacoppo S, Trubiani O, Diomede F, Piattelli A, Bramanti P, Mazzon E. Conditioned medium of periodontal ligament mesenchymal stem cells exert anti-inflammatory effects in lipopolysaccharide-activated mouse motoneurons. Experimental Cell Research;349(1):152-161 (2016).
  15. Rajan TS, Scionti D, Diomede F, Grassi G, Pollastro F, Piattelli A, Cocco L, Bramanti P, Mazzon E, Trubiani O. Gingival stromal cells as an in vitro model: Cannabidiol modulates genes linked with Amyotrophic Lateral Sclerosis. Journal Cellular Biochemestry; 118(4):819-828. (2017).
  16. Cianci E, Trubiani O, Diomede F, Merciaro I, Meschini I, Bruni P, Croce F, Romano M. Immobilization and delivery of biologically active Lipoxin A4 using electrospinning nanotechnology International Journal of Pharmaceutics. International Journal of Pharmaceutics 515(1-2):254-261 (2016).
  17. Cavalcanti M, Silva U, Leal-Junior EC, Lopes-Martins R, Marcos R, Pallotta R, Diomede F, Trubiani O, De Isla N. Comparative study of the physiotherapeutic and drug protocol (PDP) and low level laser (LLL) irradiation in the treatment of pain associated to temporomandibular dysfunction (TMD). Photomedicine and Laser Surgery. 34(12):652-656 (2016).
  18. Diomede F, Zini N, Gatta V, Fulle S, Merciaro I, D’Aurora M, La Rovere RML, Pizzicannella J, Ballerini P, Piattelli A, Trubiani O. Engineered Cortico-Cancellous Bone And Xeno-Free Human Periodontal Ligament Stem Cells To Instruct Bone Regenerative Process. European Cells and Materials 32;181-201 (2016).
  19. Trubiani O, Guarnieri S, Diomede F, Mariggiò MA, Merciaro I, Morabito C, Cavalcanti MF, Cocco L, Ramazzotti G. Nuclear translocation of PKCα isoenzyme is involved in neurogenic commitment of human neural crest-derived periodontal ligament stem cells. Cellular Signalling 28;11, 1631-1641 (2016).
  20. Trubiani O, Giacoppo S, Ballerini P, Diomede F, Piattelli A, Bramanti P, Mazzon E. Alternative source of stem cells derived from human periodontal ligament: a new treatment for experimental autoimmune encephalomyelitis. Stem Cell Research & Therapy 7;1, 1 (2016).
  21. Cianci E, Recchiuti A, Trubiani O, Diomede F, Marchisio M, Miscia S, Colas RA, Dalli J, Charles Serhan N, Romano M. Human Periodontal Stem Cells Release Specialized Pro-resolving Mediators And Carry Immunomodulatory and Pro-healing Properties Regulated by Lipoxins. Stem Cells and Translational Medicine 5;1, 20-32 (2016).
  22. Manescu A, Giuliani A, Mohammadi S, Tromba G, Mazzoni S, Diomede F, Piattelli A, Trubiani O. Osteogenic potential of dualblocks cultured with human periodontal ligament stem cells: in vitro and synchrotron microtomography study. Journal of Periodontal Research 51;1, 112-24 (2016).
  23. Cavalcanti MFXB, Maria DA, de Isla N, Leal-Junior ECP, Joensen J, Bjordal JM, Lopes-Martins RAB, Diomede F, Trubiani O, Frigo L. Evaluation of the proliferative effects induced by low level laser therapy in bone marrow stem cells culture. Photomedicine and Laser Surgery 33;12, 610-6 (2015).
  24. Rapani M, Ricci L, Rapani C, Diomede F, Cardelli P. Prefabricated Composite Anterior Veneers: Retrospective Clinical Evaluation with a Four Year Follow-up. BAOJ Dentistry 1;1, 003 (2015).
  25. Sinjari B, Diomede F, Murmura G, Traini T, Merciaro I, Trubiani O, Caputi S. A cytotoxic analysis of a sardinian plant extract cream on human oral primary cell cultures: an in vitro study. J Biol Regul Homeost Agents. 29;1,103-13 (2015).
  26. Trubiani O, Piattelli A, Gatta V, Marchisio M, Diomede F, D'Aurora M, Merciaro I, Pierdomenico L, Maraldi NM, Zini N. Assessment of an efficient xeno-free culture system of human periodontal ligament stem cells. Tissue Engineering Part C: Methods 21;1, 52-64 (2015).
  27. Diomede F, Caputi S, Merciaro I, Frisone S, D’Arcangelo C, Piattelli A, Trubiani O. Pro-inflammatory cytokine release, and cell growth inhibition in primary human oral cells after exposure to endodontic sealer. International Endodontic Journal 47; 9, 864-72 (2014).
  28. Sinjari B, Guarnieri S, Diomede F, Merciaro I, Mariggio M A, Caputi S, Trubiani O. Influence of titanium laser surface geometry on proliferation and on morphological features of human mandibular primary osteoblasts. Journal of Biological Regulators & Homeostatic Agents 26;3, 481-489 (2012).
  29. Trubiani O, Toniato E, Di Iorio D, Diomede F, Merciaro I, D’Arcangelo C, Caputi S. Morphological analysis and interleukin release in human gingival fibroblasts seeded on different denture based acrylic resins. Journal of Biological Regulators & Homeostatic Agents 25;3, 637-639 (2012).

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