Wenfei Jin, PhD
Associate Professor (National 1000 Young Talent)

Department of Biology
Southern University of Science and Technology (SUSTech)
1088 Xueyuan Rd. , Shenzhen, Guangdong 518055 China
Phone: +86 13725576015
E-mail: jinwf@sustc.edu.cn


 Sept.2006-Dec.2011  Ph.D. in Computational Biology, PICB and University of Chinese Academies of Sciences Supervisors: Prof. Felix Li Jin (CAS member) and Dr. Shuhua Xu
 Feb.2006-April.2006  Intern, Institute of Biochemistry and Cell Biology, SIBS, CAS Mentors: Prof. Mofang Liu and Prof. Enduo Wang (CAS member)


  Dr. Wenfei Jin is an Associate Professor in Department of Biology in Southern University of Science and Technology (SUSTech). Dr. Jin received his bachelor's degree from Zhengzhou University in 2006. He received his Ph.D. in Computational biology from Chinese Academy of Sciences and Max Planck Society Partner Institute for Computational Biology (PICB) with Prof. Li Jin (CAS member) and Prof. Shuhua Xu in 2012. Dr. Jin completed his Postdoc Fellow in systems biology at National Institutes of Health (NIH) with Dr. Keji Zhao in 2017. He was selected to “National 1000 young talents program of China” and joined in Southern University of Science and Technology (SUSTech) in 2017. Dr. Jin works on population genetics and precision medicine related field since his Ph.D. program. He has published >20 research articles and book chapters, including first/co-fist author articles on Nature, AJHG, Genome Res, Genome Biol and HMG. Dr. Jin and his colleagues developed single cell DNase-seq (scDNase-seq) that could provide key regulatory information for precision medicine (Jin, et.al, 2015 Nature). Dr. Jin is the recipient of many honors and awards including Springer Theses, CAS Excellent Doctoral Dissertation and NHLBI Orloff Award. Dr. Jin is especially interested in promoting the applications of single cell sequencing in clinical diagnosis and medical consultation.

Research Interest

 Dr. Jin’s lab is interested in identifying genetic/epigenetic changes that drive oncogenesis, and developing disease risk prediction model for precision medicine. The long-term goal of the lab is to develop efficient personalized treatment for cancers based on patients’ genetic background. In near future, the lab will focus on investigating genetic/epigenetic heterogeneity and micro-evolution of cancer cells using single cell sequencing related technologies.

Scientific Activities

2017 National 1000 Young Talents Program, China
2017 Distinguished Scientist Award, NIH-CSSA
2016 Orloff innovation Awards, NHLBI, USA
2016 Fellows Award for Research Excellence (FARE), NIH, USA
2013 Excellent Doctoral Dissertation, Chinese Academy of Sciences
2012 First-author Awards, PICB
2012 Outstanding Graduate Award, University of Chinese Academy of Sciences
2012 SIBS-Eli Lilly Outstanding Ph.D. Thesis Awards, Eli Lilly
2011 Travel Awards, 12th International Congress of Human Genetics (ICHG)/61th ASHG
2011 Pfizer Awards, Shanghai Institutes for Biological Sciences
2010 Di’ao scholarship Awards, Chinese Academy of Sciences


  1. Gang Ren#, Wenfei Jin#, Kairong Cui#, Joseph Rodrigez, Daniel R. Larson and Keji Zhao. 2017 CTCF-mediated enhancer-promoter interaction is a critical regulator of cell-to-cell variation of gene expression. Mol Cell. In press
  2. Yi Zhang, Wai Lim Ku, Shuai Liu, Kairong Cui, Wenfei Jin, Qingsong Tang, William Lu, and Bing Ni and Keji Zhao. 2017 Genome-wide identification of histone H2A- and histone variant H2A.Z-interacting proteins by bPPI-seq. Cell Res. DOI: 10.1038/cr.2017.112 (Advanced online)
  3. Wenfei Jin#, Qingsong Tang#, Mimi Wan, Kairong Cui, Yi Zhang, Gang Ren, Bing Ni, Jeffrey Sklar, Teresa M. Przytycka, Richard Childs, David Levens, and Keji Zhao. 2015 Genome-wide Detection of DNase I Hypersensitive Sites in Single Cells and FFPE Samples. Nature. 528:142-146. (Highlighted by Nature Review Genetics)
  4. Daniel Kraushaar#, Wenfei Jin#, Alika Maunakea, Brian Abraham, Misook Ha, Keji Zhao. 2013. Genome-wide H3.3 incorporation dynamics reveal distinct categories of histone variant H3.3 turnover. Genome Biol. 14: R121. (# equal contribution)
  5. Wenfei Jin, Shuhua Xu, Haifeng Wang, Yongguo Yu, Yiping Shen, Bailin Wu, Li Jin. 2012. Genome-Wide Detection of Natural Selection in African Americans Pre-and Post-Admixture. Genome Res. 22: 519-527.
  6. Wenfei Jin, Pengfei Qin, Haiyi Lou, Li Jin, Shuhua Xu. 2012. A Systematic Characterization of Genes Underlying Both Complex and Mendelian Diseases. Hum Mol Genet. 21: 1611-1624.
  7. Wenfei Jin, Sijia Wang, Haifeng Wang, Li Jin, Shuhua Xu. 2012. Exploring Population Admixture Dynamics via Empirical and Simulated Genome-Wide Distribution of Ancestral Chromosomal Segments. Am J Hum Genet. 91: 849-862
  8. Wenfei Jin#, Ran Li#, Ying Zhou, Shuhua Xu. 2014. Distribution of ancestral chromosomal segments in admixed genomes and its implications for inferring population history and admixture mapping. Euro J Hum Genet. 22, 930-937. (# equal contribution)
  9. Erli Wang#, Wenfei Jin#, Wenyuan Duan#, Bin Qiao, Shuna Sun, Guoying Huang, Kaihu Shi, Li Jin, Hongyan Wang. 2013. Association of Two Variants in SMAD7 with the Risk of Congenital Heart Disease in the Han Chinese Population. PLoS ONE. 8: e72423. (# equal contribution)
  10. Shuhua Xu, Wenfei Jin, Li Jin. 2009. Haplotype Sharing Analysis Showing Uyghurs Are Unlikely Genetic Donors. Mol Biol Evol. 26: 2197-2206.
  11. Shuhua Xu, Xianyong Yin, Shilin Li, Wenfei Jin, Haiyi Lou, Ling Yang, Xiaohong Gong, Hongyan Wang, Yiping Shen, Xuedong Pan, Yungang He, Yajun Yang, Yi Wang, Wenqing Fu, Yu An, Jiucun Wang, Jingze Tan, Ji Qian, Xiaoli Chen, Xin Zhang, Yangfei Sun, Xuejun Zhang, Bailin Wu, Li
  12. Jin. 2009. Genomic Dissection of Population Substructure of Han Chinese and Its Implication in Association Studies. Am J Hum Genet. 85: 762-774.
  13. Shuhua Xu, Shilin Li, Yajun Yang, Jingze Tan, Haiyi Lou, Wenfei Jin, Ling Yang, Xuedong Pan, Jiucun Wang, Yiping Shen, Bailin Wu, Hongyan Wang, and Li Jin. 2011. A Genome-Wide Search for Signals of High Altitude Adaptation in Tibetans. Mol Biol Evol. 28: 1003-1011.
  14. Haiyi Lou, Shilin Li, Yajun Yang, Xin Zhang, Wenfei Jin, Bailin Wu, Li Jin, Shuhua Xu. 2011. A Map of Copy Number Variations in Chinese Populations. PLoS ONE. 6: e27341.
  15. Pengfei Qin, Zhiqiang Li, Wenfei Jin, Dongsheng Lu, Haiyi Lou, Jiawei Shen, Li Jin, Yongyong Shi and Shuhua Xu. 2014. A panel of ancestry informative markers to estimate and correct potential effects of population stratification in Han Chinese. Euro J Hum Genet. 22: 248-53.
  16. Shi Yan , Chuan-Chao Wang, Hong-Xiang Zheng, Wei Wang, Zhen-Dong Qin, Lan-Hai Wei, Yi Wang, Xue-Dong Pan, Wen-Qing Fu, Yun-Gang He, Li-Jun Xiong, Wen-Fei Jin, Shi-Lin Li, Yu An, Hui Li, Li Jin. 2014. Y chromosomes of 40% chinese descend from three neolithic super-grandfathers. PloS one, e105691
  17. Haiyi Lou, Shilin Li, Wenfei Jin, Ruiqing Fu, Dongsheng Lu, Xinwei Pan, Huaigu Zhou, Yuan Ping, Li Jin, Shuhua Xu. 2015. Copy number variations and genetic admixtures in three Xinjiang ethnic minority groups. Euro J Hum Genet. 23:536-42
  18. Wan Isa Hatin, Ali Etemad, Wenfei Jin, Pengfei Qin, Shuhua Xu, Li Jin, Soon-Guan Tan, Pornprot Limprasert, Merican Amir Feisal, Mohammed Rizman-Idid, Bin Alwi Zilfalil, HUGO Pan-Asian SNP Consortium. 2014. A genome wide pattern of population structure and admixture in peninsular Malaysia Malays. HUGO J, 8:1-18
  19. Hao Hu, Xiang Liu, Wenfei Jin, H.Hilger Ropers, Thomas Wienker. 2015. Evaluating information content of SNPs for sample tagging in re-sequencing projects. Sci. Rep. 5:10247
  20. Shuhua Xu, Wenfei Jin. 2012. Population Genetics in the Genomic Era. Studies in Population Genetics, M. Carmen Fusté (Ed.). ISBN 978-953-51-0588-6. Intech. UK
  21. Wenfei Jin. 2015. Admixture Dynamics, Natural Selection and Diseases in Admixed Populations. ISBN 978-94-017-7408-6. Springer.

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