Trachette L Jackson, PhD
Professor of Mathematics

University of Michigan
Ann Arbor, Michigan, USA
Phone: (734) 764-8537


 1998 PhD in Applied Mathematics University of Washington, Washington, USA
 1996 MS in Applied Mathematics University of Washington, Washington, USA
1994 BS in Mathematics Arizona State University, Arizona , USA


Dr. Trachette L. Jackson is a Professor in the Department of Mathematics in the College of Literature, Science, and the Arts at the University of Michigan. Her research lies within the overarching field of mathematical biology, which can be characterized by the use of sophisticated mathematical, statistical and computational modeling techniques in order to facilitate a deep understanding of biology, for human benefit and the mitigation of human harm. Within Mathematical Biology, she specializes in Computational Cancer Research or Mathematical Oncology. In 2003, she became one of only two African American women to receive the prestigious Alfred P. Sloan Research Award in Mathematics, and in 2005 she received the James S. McDonnell 21st Century Scientist Award. A highlight of her career was becoming the first woman to receive the 2010 Blackwell-Tapia Prize, honoring a mathematician who has contributed significantly to research and to addressing the program of underrepresentation of minorities in mathematics. In 2011, Dr. Trachette L. Jackson founded a new Applied and Interdisciplinary Mathematics Bridge to the PhD program at the University of Michigan in order to address the national challenge of educating and training a diverse scientific workforce capable of unifying the fields of mathematics and the natural sciences. Her commitment to theoretical and computational cancer research is further evidenced by her joint effort to spearhead a Quantitative Oncology subsection in the authoritative journal Cancer Research, for which she now serve as a Senior Editor. She had built her career on collaborative research and educational activities that cut across traditional disciplinary boundaries, and she envisions that this type of research will eventually change the face of cancer research.

Research Interest

  • Mathematical Biology (the application of mathematics to medicine, tumor biology, chemotherapeutic strategies, and cell signalling).
  • Partial Differential Equations.
  • Asymptotic and Perturbation Methods.


Scientific Activities

Teaching Experience
2008-Present Professor of Mathematics, University of Michigan, Michigan, USA
2003-2008 Associate Professor of Mathematics, University of Michigan, Michigan, USA
2000-2003 Assistant Professor of Mathematics, University of Michigan, Michigan, USA
1999-2000 John Hope Franklin Postdoctoral Fellow of Mathematics, Duke University, North Carolina, USA
1995-1998 NSF Graduate Fellow of Mathematics, University of Washington
Professional Activities

Membership for Professional Organizations

2016 SIAM Life Sciences Conference, Organizing Committee Member
2016 AWM Workshop at SIAM Annual Meeting, Co-organizer
2013 WhAM! Research Collaboration Workshop for Women, Co-organizer
2013 AMS Centennial Fellowship Committee
2013 AWM Research Symposium, Session Organizer
2012-2013 NIH MABS Study Section Member
2012 MSRI Spring Opportunities Workshop Organizer
2012-2015 IMA Board of Governors
2010-2013 AWM Executive Committee (Elected Position)
2008-Present Senior Editor, Cancer Research
2008-Present SIAM Diversity Committee
2008-Present Diversity Committee for the Mathematical Biology Institute
2008-2011 Advisory Board for the NIMBioS
2006-2009 Steering Committee Member for ABRCMS
2006 SIAM ANNUAL MEETING, Organizing Committee Member
2006 IPAM Cells and Materials, Organizing Committee Member
2004 Co-organizer, Annual Meeting of the Society for Mathematical Biology
Co-organizer, University of Michigan's Mathematical Biology Research Group
Member, Society for Mathematical Biology
Member, Society for Industrial and Applied Mathematics
Member, Association for Women in Mathematics
Honors & Awards
2016 Featured in Stem Gems: How 44 Women Shine in Science, Technology, Engineering and Mathematics, and How You Can Too!
2014 DAPCEP Real McCoy Award
2013 Featured in Darwin's Extra Sense
2013 Interviewed for the Scientific American blog, "Roots of Unity" and AWM News
2012 Simon's Foundation Fellowship Advertised in the NY Times
2012 Elizabeth Caroline Crosby Award
2012 Elected to the IMA Board of Governors
2011 Imes-Moore Award
2011 Featured in a 2-page article in SIAM News
2011 Featured on the AMS Women in Mathematics Poster
2010 Blackwell-Tapia Award
2010 Present Director of Marjorie Lee Browne Bridge Program
2008 Present Senior Editor of Mathematical Oncology for Cancer Research
2008 Diverse: Issues In Higher Education Standout Scholar
2005 James S. McDonnell 21st Century Research Award
2003 Robert D. and Janet E. Neary Faculty Research Award
2003 Amoco Faculty Undergraduate Teaching Award
2003 Alfred P. Sloan Research Fellowship
2003 WWNF Career Enhancement Fellowship for Junior Faculty
2003 Elizabeth Caroline Crosby Research Award


  1. Jackson TL, Jain HV. Mathematical Modeling of Cellular Cross Talk between Endothelial and Tumor Cells Highlights Counterintuitive Effects of VEGF Targeted Therapies. Bull Math Bio (2017).
  2. Nazari F, Pearson AT, Nor JE, Jackson TL. A Mathematical Model for IL-6- mediated, Stem Cell Driven Tumor Growth and Targeted Treatment.
  3. Farhat A, Jiang D, Cui D, Keller ET, Jackson TL. An Integrative Model of Prostate Cancer Interaction With the Bone Microenvironment.
  4. Pearson A, Ingram P, Bai S, Yoon E, Jackson TL, Buckanovich RJ. Sampling From Single-Cell Observations to Predict Tumor Cell Growth In-vitro and In-vivo.
  5. Yu A, Jackson TL, Tsume Y, Koenigsknecht M, Wysocki J, Marciani L, Amidon GL, Frances A, Baker JR, Hasler W, Wen B, Pai A, Sun D. Mechanistic Fluid Transport Model to Estimate Gastrointestinal Fluid Volume and its Dynamic Change Over Time.
  6. Swiecicki PL, Bellile E, Sacco AG, Pearson AT, Taylor JM, Jackson TL, Chepeha DB, Spector ME, Shuman A, Malloy K, Moyer J, McKean E, McLean S, Sukari A, Wolf GT, Eisbruch A, Prince M, Bradford C, Carey TE, Wang S, Nor JE, Worden FP. A phase II trial of the BCL-2 homolog domain 3 mimetic AT-101 in combination with docetaxel for recurrent, locally advanced, or metastatic head and neck cancer. Invest New Drugs (2016) 34(4):481-489.
  7. Pearson A, Finkel K, Warner K, Nor F, Tice D, Martins M, Jackson TL, Nor JE. Patient Derived Xenograft (PDX) Tumors Increase Growth Rate with Time Oncotarget (2016) 7(7):7993-8005.
  8. Pearson AT, Jackson TL, Nor JE. Modeling head and neck cancer stem cell-mediated tumorigenesis. Cell Mol Life Sci (2016) 73(17):3279-89.
  9. Cook, AL, Ziazadeh, DR, Lu J, Jackson TL. A Multiscale Modeling Framework for Investigating Synergism Between Chemotherapy and Molecular Targeted Therapies. DCDS-B (2015) 2(6): 1219-1235.
  10. Jackson TL, Komarova NL, Swanson KR. Mathematical Oncology: Using Mathematics to Enable Cancer Discoveries. Am Math Monthly (2014) 21(9): 840-856.
  11. Zheng X, Koh GY, Jackson TL. A continuous model of angiogenesis: initiation, extension, and maturation of new blood vessels modulated by vascular endothelial growth factor angiopoietins, platelet derived growth factor-B, and pericytes Dis Cont Dynam Sys B (2013) 18(4) 1109-1154.
  12. Gentry SN and Jackson TL. A Mathematical Model of Cancer Stem Cell Driven Tumor Initiation: Implications of Niche Size and Loss of Homeostatic Regulatory Mechanisms. PLoS ONE (2013) 8(8): e71128.
  13. Jain HV and Jackson TL. A Hybrid Model of the Role of VEGF Binding in Endothelial Cell Migration and Capillary Formation. Frontiers in Oncol (2013) 3(102) 1-15.
  14. Kim JK and Jackson TL. Mechanisms for enhancing sustainability of p53 pulses PLoS One (2013) 8(6) e65242.
  15. Jackson TL. Modeling Tumor Vasculature: Molecular, Cellular, and Tissue Level Aspects and Implications Springer Pub Group (2012).
  16. Gentry BG, Gentry SN, Jackson TL, Zemlicka J, Drach JC. Phosphorylation of Endogenous and Fraudulent Nucleotides to Di- and Triphosphates by Guanosine Monophosphate Kinase Biochem Pharm (2011) 80: 43-49.
  17. Zheng X, Jackson TL. A Multiscale Model of Cell Elongation, Proliferation and Maturation During Angiogenesis. Bull Math Bio (2010) 72: 830-868.
  18. Bauer AL, Rohlf T, Jackson TL, Jiang Y. Receptor Cross-Talk in Angiogenesis: Mapping Environmental Cues to Cell Phenotype using a Stochastic, Boolean Signaling Network. J Theoret Biol (2010) 64(3): 838-846.
  19. Ventrua AC, Jackson TL, Merajver SD. On the Role of Cell Signaling Models in Cancer Research Cancer Res (2009) 69(400): 400-402.
  20. Gentry SN, Ashkenazi R, Jackson TL. A Maturity-Structured Mathematical Model of Mutation Acquisition in the Absence of Homeostatic Regulation Math Model Nat Phenom (2009) 4(2): 156-182.
  21. Bauer AL, Jackson TL, Jiang Y. Topography of Extracellular Matrix Mediates Vascular Morphogenesis and Migration Speeds PLoS (2009) 5(7) e1000445.
  22. Jain HV, Nor JE, Jackson TL. Quantification of Endothelial Cell-Targeted Anti Bcl-2 Therapy and its Suppression of Tumor Growth and Vascularization Molec Cancer Therap (2009) 8(10):2926-2936.
  23. Ashkenazi R, Heusel SN, Jackson TL. Pathways to Tumorigenesis: Mathematical Modeling of Cancer Stem Cell Hypothesis Neoplasia (2008) 10(11): 11701182.
  24. Bortz DM, Jackson TL, Taylor KA, Younger JG. Klebsiella pneumoniae occulation dynamics. Bull. Math. Biol. (2008) 70(3) pp. 745-768.
  25. Chung H, Cartwright MM, Bortz DM, Jackson TL, Younger JG. Dynamical System Analysis of Staphylococcus Epidermidis Bloodstream Infection Shock (2008) 30(5): 518-526.
  26. Jain HV, Nor JE, Jackson TL. Investigating the VEGF-Bcl-2-CXCL8 Pathway and Its Role in Sustained Angiogenesis Bull Math Biol (2008)70(1): 89-117.
  27. Kiel MJ, He S, Ashkenazi R, Heusel SN, Teta M, Kushner JA, Jackson TL, Morrison SJ. Hematopoietic stem cells do not segregate chromosomes asymmetrically and cannot be reliably identi_ed based on bromo-deoxyuridine label-retention Nature (2007) 449xiii: 238-242.
  28. Bauer AL, Jackson TL, Jiang Y. A Cell-Based Model Exhibiting Branching and Anastomosis During Tumor-Induced Angiogenesis Biopys J (2007) 92: 1-17.
  29. Dong Z, Song W, Sun Q, Zeitlin BD, Karl E, Spencer DM, Jain HV, Jackson TL, Nunez G, Nor JE. Apoptotic Requirement for Microvessel Disruption Exp. Cell Res. (2007) 313(6): 3645-3657.
  30. Ashkenazi R, Jackson TL, Dontu G, Wicha MS. Breast Cancer Stem Cells – Research Opportunities Utilizing Mathematical Modeling (2007) Stem Cell Rev 3(2): 176-182.
  31. Wu M, Kwon HY, Rattis F, Blum J, Zhao C, Ashkenazi R, Jackson TL, Gaiano N, Oliver T, Reya T. Imaging Hematopoietic Precursor Division in Real-Time Cell-Stem Cell (2007) 1(5): 541-554.
  32. Jackson TL, Ashkenazi R, Heusel SN, Jain HV. Cancer Modeling: A Perspective on What's New and What's Next Contemp Math (2006) 40: 229-243.
  33. Garner AL, Lau YY, Jackson TL, Uhler MD, Jordan D, Gilgnebach RM. Incorporating spatial dependence into a multicellular tumor spheroid growth model. J Appl Phys (2005) 98: 124701-8.
  34. Ben-David I, Price SE, Bortz DM, Cohen SE, Bauer AL, Jackson TL, Younger JG. Dynamics of intrapulmonary bacterial growth in a murine model of repeated microaspiration. Am J Res Cell and Molec Biol (2005) 33: 476-482.
  35. Bushnell PJ, Shafer TJ, Bale AS, Boyes WK, Simmons JE, Eklund C, Jackson TL. Developing an Exposure-Dose-Response Model for Organic Solvents: Overview and Progress on in vitro Models and Dosimetry. Envir Tox Pharm (2005) 19(3): 607-614.
  36. Jackson TL, A Mathematical Investigation of the Multiple Pathways to Recurrent Prostate Cancer: Comparison with Experimental Data. Neoplasia (2004) 6(6): 697-704.
  37. Lai R, Jackson TL. A Mathematical Model of Receptor-Mediated Apoptosis: Dying to Know Why FasL is a Trimer. Math. Biosci Engin (2004) 1(2): 325-338.
  38. Jackson TL. A Mathematical Model of Prostate Tumor Growth and Androgen-Independent Relapse. Dis Conti. Dynam Sys (2004) 4(1): 187-202.
  39. Jackson TL, Arciero J, Kirschner D. A Mathematical Model of Tumor Immune Evasion and siRNA Treatment. Dis Contin Dynam Sys (2004) 4(1): 39-58.
  40. Criminale WO, Jackson TL, Nelson PW. Limit Cycle-Strange Attractor Competition. Stud Appl Math (2004) 112: 133-160.
  41. Jackson TL. Intracellular Accumulation and Mechanism of Action of Doxorubicin in a Spatio-Temporal Tumor Model. J Theor Biol (2003) 220(2): 201-213.
  42. Jackson TL. Vascular Tumor Growth and Treatment: Consequences of polyclonality, competition, and dynamic vascular support. J Math Biol (2002) 44(3): 201-226.
  43. Lubkin SR, Jackson TL. Multiphase Mechanics of Capsule Formation in Tumors. J. Biomech Eng (2002) 124(2): 237-243.
  44. Jackson TL, Byrne HM. A Mechanical Model of Tumor Encapsulation and Transcapsular Spread. Math Biosci (2002) 180: 307-328.
  45. Jackson TL, Byrne HM. A Mathematical Model to Study the E_ects of Drug Resistance and Vasculature on the Response of Solid Tumors to Chemotherapy. Math Biosci (2000) 164: 17-38.
  46. Jackson TL, Senter PD, Murray JD. Development and Validation of a Mathematical Model to Describe Anti-cancer Prodrug Activation by Antibody-Enzyme Conjugates. J Theo Med (2002) 2(2): 93-111.
  47. Jackson TL, Lubkin SR, Murray JD. Theoretical Analysis of Conjugate Localization in Two-Step Cancer Chemotherapy, J Math Biol (1999) (39)4: 353-376.
  48. Jackson TL, Lubkin SR, Siemers NO, Kerr D, Senter PD, Murray JD. Mathematical and Experimental Analysis of Localization of Anti-Tumor Antibody Enzyme Conjugates. Br. J. of Cancer (1999) 80(11): 1747-1753.
  49. Tang B, Sitomer A, Jackson TL. Population Dynamics and Competition in Chemostat Models with Adaptive Nutrient Uptake, J Math Biol (1997) 35: 453-479.

Systems Biology Research Flyer