Kelli Bullard Dunn
KELLI BULLARD DUNN, MD
Professor of General Surgery

University of Louisville
USA

Education

1984-1988

Stanford University, Stanford, CA

B.A. in Human Biology with distinction

1988-1992

Harvard Medical School, Boston, MA

M.D.

Postdoctoral Training

1992-2000

 University of California, San Francisco
San Francisco, CA
Resident in General Surgery

2000-2001 

 University of Minnesota
Minneapolis, MN
Fellow, Colon& Rectal Surgery

 

Biography

 

Research Interest

The growth and progression of colorectal carcinoma. Her clinical research involves patterns of recurrence in colorectal cancer and surgical complications of neoadjuvant therapy.

 

Professional Activities:

2015-Present   Vice Dean, Community Engagement and Diversity, University of Louisville, Louisville, KY
2013-2015       Senior Associate Dean for Statewide Initiatives and Outreach, University of Louisville, Louisville, KY
2011-Present    Professor of Surgery, University of Louisville, Louisville, KY (with tenure)
2011-Present    Associate Director of Clinical Programs, James Graham Brown Cancer Center, Louisville, KY
2011-Present    Director, Colon and Rectal Cancer Multidisciplinary Program, James Graham, Brown Cancer Center, Louisville, KY
2011

 Professor of Surgical Oncology, Roswell Park Cancer Institute
2010-2011

 Chief, Division of Colon and Rectal Surgery, Roswell Park Cancer Center, Institute, Buffalo, NY
2005-2011

 Associate Professor, Department of Surgical Oncology, Roswell Park Cancer, Center Institute and the State University of New York, Buffalo, NY
2003-2005

 Assistant Professor of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN
2003-2005

 Assistant Professor, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN (Joint Appointment)
2001-2005

 Assistant Professor of Surgery, University of Minnesota, Minneapolis, MN
2001-2005

 Member, University of Minnesota Cancer Center, Minneapolis, MN

 

Publications

  1. Bullard KM and Harrison MR. Before the horse is out of the barn: Fetal surgery for hydrops. Sem Perinatol 1995; 19:462-473.
  2. Bullard KM and Adzick NS. Pediatric thoracoscopy: a new vista. Pediatr Pulm 1996; 22:129-235.
  3. Cass DL, Bullard KM, Sylvester KG, Yang EY, Sheppard D, Herlyn M, Adzick NS. Epithelial integrin expression is rapidly upregulated in human fetal wound repair. Surg Forum 1996; XLVII: 765-767.
  4. Bullard KM, Cass DL, Adzick NS, Banda MJ. TGF-b1 decreases interstitial collagenase in healing human fetal skin. Surg Forum 1996; XLVII:762-765.
  5. Mychaliska GB, Bullard KM, Harrison, MR. In utero management of congenital diaphragmatic hernia. Clin Perinatol 1996; 23:823-841.
  6. Bullard KM, Sonne J,  Hawgood S, Harrison MR, Adzick NS. Tracheal ligation increases cell proliferation but decreases surfactant protein in fetal murine lungs in vitro. J Pediatr Surg 1997; 32: 207-213.
  7. Cass DL, Bullard KM, Sylvester KG, Yang EY, Longaker MT,  Adzick NS. Wound size and gestational age modulate scar formation in fetal wound repair. J Pediatr Surg 1997; 32: 411-415.
  8. Bullard KM, Adzick NS, and Harrison MR. A mediastinal window approach to aortopexy. J Pediatr Surg 1997; 32:680-681.
  9. Constant JS, Bullard KM, Hunt TK, Longaker MT. Increased vascular endothelial growth factor in hypoxic fetal wounds. Surg Forum 1997; XLVIII:519-521.
  10. Bullard KM, Mudgett JM, Werb Z, Banda MJ. Delayed wound healing in stromelysin-1 knock-out mice is associated with prolonged MW 29,000 collagenase activity. Surg Forum 1997; XLVIII:684-686.
  11. Harrison MR, Adzick NS, Bullard KM, Farrell JA, Howell LJ, Rosen MA, Sola A, Goldberg JD, Filly RA. In utero repair of congenital diaphragmatic hernia: A prospective trial. J Pediatr Surg 1997; 32:1637-1642.
  12. Bullard KM, Cass DL, Adzick NS, Banda MJ. TGF-b1 decreases interstitial collagenase in healing human fetal skin. J Pediatr Surg 1997; 32:1023-1027.
  13. Stelnicki, EJ, Bullard KM, Harrison MR, Cass DL, and Adzick NS. A new in vivo model for the study of fetal wound healing.  Ann Plastic Surg 1997; 34:374-380.
  14. Bullard KM, Banda MJ, Arbeit JM, Bergsland E, Young DM. Progressive squamous epithelial neoplastic cells from transgenic mice invade acellular dermis in vivo. Invasion Metast 1997; 17:42-52.
  15. Cass DL, Bullard KM, Sylvester KG, Yang EY, Sheppard D, Herlyn M, Adzick NS. Epithelial integrin expression is rapidly upregulated in human fetal wound repair. J Pediatr Surg 1998; 33:312-316.
  16. Bullard KM, Mudgett J, Scheuenstuhl H, Hunt TK, Banda MJ. Stromelysin-1 deficient fibroblasts display impaired contraction in vivo. J Surg Res 1999; 84:31-34.
  17. Bullard KM, Lund L, Mudgett JS, Mellin TN, Hunt TK, Murphy B, Ronan J, Werb Z, Banda MJ. Impaired wound contraction in stromelysin-1 deficient mice. Ann Surg, 1999: 230:260-265.
  18. Bullard KM, Madoff RD, Gemlo BT. Is ileoanal pouch function stable over time? Results of a prospective audit. Dis Colon Rectum, 2002;45:299-304.
  19. Bullard KM, Tuttle TM, Rothenberger DA, Madoff RD, Baxter NN, Finne CO, Spencer MP. Surgical therapy for anorectal melanoma. J Amer Coll Surg, 2003; 196:206-211.
  20. Fitzharris G, Garcia-Aguilar J, Congilosi S, Bullard K, Madoff R, Goldberg S, Lowry A. Quality of life after subtotal colectomy for slow transit constipation – Both quality and quantity count. Dis Colon Rectum, 2003;46:433-440
  21. Bullard KM, Kim H-R, Wheeler MA, Wilson CW, Neudauer CL, Simpson MA, McCarthy JB. Hyaluronan synthase-3 is upregulated in metastatic colon carcinoma cells and manipulation of expression alters matrix retention and cellular growth. Int J Cancer, 2003; 107:739-746
  22. Krabbenhoft DM, Hoang CD, Morris A, Hunter DW, Payne WD, Dunn DL, Bullard KM. Complications of chronic pelvic radiation injury. J Amer Coll Surg, 2004; 198:1022-1023.
  23. Kim H-R, Wheeler M, Wilson C, Iida J, Eng D, Simpson M, McCarthy J, Bullard KM. Hyaluronan facilitates invasion of colon carcinoma cells in vitro via interaction with CD44. Cancer Research, 2004; 64:4569-4576.
  24. Laurich C, Wheeler MA, Iida J, Neudauer C, McCarthy JB, Bullard KM. Hyaluronan Mediates adhesion of metastatic colon carcinoma cells. J Surg Res, 2004; 122:70-74.
  25. St. Hill C, Bullard K, Walcheck B. Expression of the high affinity selectin ligand C2-O-sLeX by colon carcinoma cells. Cancer Letters, 2005; 217:105-113. 
  26. Bullard KM, Trudel JL, Baxter NN, Rothenberger DA. Primary perineal closure after radiotherapy and abdominoperineal resection has a high incidence of wound failure. Dis Colon Rectum 2005; 48:438-443.
  27. Baxter NN, Rothenberger DA, Morris AM, Bullard KM. Adjuvant radiation for rectal cancer: Do we measure up to the standard of care? Dis Colon Rectum 2005; 48:9-15.
  28. Hoang CD, Boettcher AK, Jesserun JS, Pambuccian SE, Bullard KM. An unusual rectosigmoid mass: Endometrioid carcinoma arising in colonic endometriosis. Am Surg 2005; 8:694-697.
  29. McCarthy J, Turley E, Wilson C, Price M, Bullard K, Beck M, Simpson M. Hyaluronan biosynthesis in prostate carcinoma growth and metastasis. Proceedings of HA2003 Meeting.    e-publication: http://www.matrixbiologyinstitute.org/ha03/ch4/index.htm (2005).
  30. Goldberg H, Baxter NN, Hertz M, Madoff RD, Ricciardi R, Bullard KM. Colon and rectal complications in heart and lung transplant patients. J Amer Coll Surg 2006; 202:55-61.
  31. Papaconstantinou H, Bullard KM, Rothenberger DA, Madoff RD. Salvage abdominoperineal resection after failed Nigro protocol: Modest success, major morbidity. Colorectal Disease 2006; 8:124-129.
  32. Cai S, Cannizzo F, Bullard Dunn K, Gibbs JF, Czuczman M, Rajput A. The role of surgical intervention in non-Hodgkins lymphoma of the colon and rectum. Am J Surg 2007; 193:409-412.
  33. Merg A, Wirtzfeld D, Wang J, Cheney R, Bullard Dunn K, Rajput A. Viability of endoscopic and excisional treatment of early rectal carcinoids. J Gastrointestinal Surgery 2007; 11: 893-897.
  34. Puthillath A, Bullard Dunn K, Rajput A , Smith J, Yang G, Wilding G, Tan W, Gupta B, Fakih MG. Safety and Efficacy of Upfront Chemotherapy in Unresected Metastatic Colorectal Cancer. Clinical Colorectal Cancer. Clin Colorectal Cancer 2007; 6:710-715.
  35. Smith R,  Hicks D, Lele S, Tomjanovich P, Rajput A, Bullard Dunn K.  Adenocarcinoma arising in perianal Crohn’s disease. American Surgeon 2008; 74: 59-61.
  36. Lee P, Windsperger A, Wilson C, McCarthy J, Wasiluk K, Rothenberger DA, Bullard Dunn K. The effect of a hyaluronan-methylcellulose membrane versus polyglactin 910 mesh on intraabdominal tumor formation in mice. Dis Colon Rectum 2008; 51: 1403-1407.
  37. Ong ES, Alassas M, Bullard Dunn K, Rajput A. Colorectal surgery in the elderly: Acceptable morbidity? Am J Surgery 2008; 195: 344-348.
  38. Fakih MG, Bullard Dunn K, Yang G, Pendyala L, Toth K, Andrews C, Rustum YM, Ross ME, LeVea C, Puthillath A, Park Y-M, Rajput Phase II study of weekly oxaliplatin in combination with oral daily capecitabine and radiation therapy with biologic correlates in the neoadjuvant treatment of rectal adenocarcinoma. International Journal of Radiation Oncology, Biology, Physics 2008; 72: 650-657.
  39. Ong ES, Alassas MA, Bogner P, Bullard Dunn K, Chey WY, Gibbs J. Total gastrectomy for gastric dysplasia in a patient with Attenuated Familial Adenomatous Polyposis. J Clinical Oncology 2008; 26: 3641-3642.
  40. Anne N, Rajput A, Bullard Dunn K, Litwin A. Idiopathic pneumatosis intestinalis of the small intestine. Am Surg 2008; 74:1127-1129.
  41. Akbari RP, Madoff RD, Parker SC, Hagerman G, Minami S, Bullard Dunn K, Mellgren AF. Anastomotic sinuses after ileoanal pouch construction: Incidence, management, and outcome. Dis Colon Rectum 2009; 52: 452-455.
  42. Wang J, Kulaylat M, Rockette H, Hassett J, Rajput A, Bullard Dunn K, Dayton M. Should total number of lymph nodes be used as a quality of care measure for stage III colon cancer? Annals of Surgery 2009; 249:559-563.
  43. Bullard Dunn K, Lee P, Wilson C, Iida J, Wasiluk K, Wheeler M, McCarthy JB. Inhibition of Hyaluronan synthase-3 decreases MMP-7 expression and activity. Surgery 2009; 145:322-329.
  44. Burt RW, Barthel JS, Bullard Dunn K, David DS, Drelichman E, Ford JM, Giardiello FM, Gruber SB, Halverson AL, Hamilton SR, Ismail MK, Jasperson K, Lazenby AJ, Lynch PM, Martin EW, Mayer RJ, Ness RM, Provenzale D, Rao MS, Shike M, Steinbach G, Terdiman JP, Weinberg D. NCCN clinical practice guidelines in oncology: Colorectal cancer screening. J Natl Compr Canc Netw 2010. 8: 8-61.
  45. Lai E, Singh R, Teng B, Zhao Y-L, Sharratt E, Howell G, Rajput A, Bullard Dunn K. Inhibition of hyaluronan synthase-3 decreases subcutaneous colon cancer growth in mice. Dis Colon Rectum 2010, 53: 475-482.
  46. Mahmoud N, Bullard Dunn K. Metastasectomy for stage IV colorectal cancer. Dis Colon Rectum 2010; 53: 1080-1092.
  47. Hepgur M, Ahluwalia MS, Anne N, Thomas J, Liu H, Schiff MD, Loud PA, Hahn TE, Bullard Dunn K, McCarthy PL.  Medical management of pneumotosis intestinalis in patients undergoing allogeneic blood and marrow transplantation.  Bone Marrow Transplantation 2011; 46:876-879.
  48. Bullard Dunn K, Heffler M, Golubvoskaya V. Evolving therapies and FAK inhibitors for the treatment of cancer. Anticancer Agents in Medicinal Chemistry 2011; 10: 722-734.
  49. Meguerditchian A, Meterissian SH, Bullard Dunn K. Anorectal melanoma: diagnosis and treatment. Dis Colon Rectum 2011; 54: 638-634.
  50. Teng B, Heffler M, Lai E, Zhao YL, LeVea C, Golubovskaya V, Bullard Dunn K. Inhibition of hyaluronan synthase-3 decreases subcutaneous colon cancer growth by increasing apoptosis. Anticancer Agents in Medicinal Chemistry 2011; 11:620-628.
  51. Franscescutti V, Miller A, Satchidanand Y, Alvarez-Perez A, Bullard Dunn K. Management of bowel obstruction in patients with stage IV cancer: Predictors of Outcome after surgery. Annals Surg Oncol 2013; 20: 707-714.
  52. Khrizman P, Niland JC, ter Veer A, Milne D, Bullard Dunn K, Carson WE, Engstrom PF, Shibata S, Skibber JM, Weiser MR, Schrag D, Benson AB. Postoperative adjuvant chemotherapy use in patients with stage II/III rectal cancer treated with neoadjuvant therapy: a national comprehensive Cancer network analysis. J Clin Oncol 2013; 31:30-38.
  53. Nassif MO, Trabulsi NH, Nahal A, Bullard Dunn K, Meguerditchian AN. Soft tissue sarcomas of the anorectum: Rare, complex, and misunderstood. J Gastrointestinal Oncology 20134:82-94.
  54. Heffler M, Golubovskaya V, Conroy J, Liu S, Wang D, Cance W, Bullard Dunn K. Fak and Has inhibition synergistically decrease colon cancer cell viability and affect expression of critical genes. Anticancer Agents Med Chem 2013 1:584-594. PMID 22934709
  55. Heffler M, Golubovskaya V, Bullard Dunn K, Cance W. Focal adhesion kinase autophosphorylation inhibition decreases colon cancer growth and enhances the efficacy of chemotherapy. Cancer Biology and Therapy 2013 14: 761-772. PMID 23792569

 

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