Jianhua Luo
Alexander A. Spector, PhD.
Research Professor
  • Department of Biomedical Engineering, Mechanical Engineering
    Johns Hopkins University, USA
    Traylor Bldg. 411
    Baltimore, MD 21205
    Phone: 410-502-6955
    Email: aspector@jhu.edu

Education

1972

Moscow State University Engineering Mechanics

M.S

1981

Russian Academy of Sciences Engineering Mechanics      Engineering Mechanics

 

Ph.D

1991

Russian Academy of Sciences

Doctor in Physical and Mathematical Sciences

 

Biography

Alexander A. Spector, Ph.D has been on the faculty of Johns Hopkins University since 1994 where he currently is a Research Professor in the Department of Biomedical Engineering. He is also affiliated with Translational Tissue Engineering Center and Institute of Nanobiotechnology. His research interests are mechanobiology, mechanotransduction, stem cell differentiation, tissue regeneration, and computational modeling. He is a Fellow of the American Society of Mechanical Engineers (ASME).

 

Research Interest

His current research interests includes The development of computational models enables better understandings of cell mechanics (electromechanics) and biophysics.

 

Professional Activities:

Special Awards and Other Honors
  • Johns Hopkins University Provost Undergraduate Research Award, faculty advisor to the undergraduate student William Hsu, 2003
  • Comcast Corporation Award in Auditory Science, National Organization for Hearing Research Foundation, 2003
  • Member of the Scientific Advisory Board of the 1st World Congress on Nanomedicine, Beijing, China, 2010
  • Elected as a Fellow of the American Society of Mechanical Engineers (ASME), 2010
  • Johns Hopkins University Provost Undergraduate Research Award, faculty advisor to the undergraduate student Richard Powers, 2011
  • Paper featured on a cover of Biophysical Journal, 2012
  • Member of Organizing Committee, International Conferences on Significant Advances in Biomedical Engineering, Philadelphia, 2015
  • Selected as a member of Organizing Committee and plenary speaker at the International Conference Nanotech-2016, Baltimore, 2016

 

Publications

Original Papers, Peer-reviewed
  1. A. Spector, and W.L. Grayson, Stem Cell Fate Decision Making: Modeling Approaches, ACS Biomaterials: Science & Engineering, 2017 (in press).
  2. R. S. Deshpande, and A. A. Spector, Modeling Stem Cell Myogenic Differentiation, Scientific Reports, 2017 (in press).
  3. R. S. Deshpande, W. L. Grayson, and A. A. Spector, A Modeling Insight into Adipose-Derived Stem Cell Myogenesis, Plos One, 2015, 10, art e0137918.
  4. Harland, W.-h. Lee, W.E. Brownell, S.X. Sun, and A.A. Spector, The Potential and Electric Field in the Cochlear Outer Hair Cell Membrane, Medical & Biol. Eng. & Comp., 2015, 53, pp. 405-413.
  5. H. Pinar Yilgor; A. Wang, A.A. Spector, and W.L. Grayson. Multistage Adipose-Derived Stem Cell Myogenesis: An Experimental and Modeling Study, Cellular and Molecular Bioengineering,2014, 7 pp. 497-509.
  6. R.J. Powers, Richard J.; S. Kulason, Atilgan, E. , W.E. Brownell, S.X. Sun, P. Barr-Gillespie, and A.A. Spector, The Local Forces Acting on the Mechanotransduction Channel in Hair Cell Stereocilia, Biophys. J. , 2014, 106, pp. 2519-2528.
  7. N. Khatibzadeh, A.A. Spector, W.E. Brownell, and B. Anvari, Rate-Dependent Dynamics of Cellular Membranes Probed by Laser Tweezers and Optical Displacement Sensing
  8. Optical Elastograthy and Tissue Biomechanics.Book Series: Proceedings of SPIE, 2014, pp. 89460P1-89460P6.
  9. N. Khatibzadeh,A.A. Spector, W.E. Brownell, and A. Bahman, Effects of Plasma Membrane Cholesterol Level and Cytoskeleton F-Actin on Cell Protrusion Mechanics,
  10. PLOS One, 2013, 8, e57147.
  11. S. Roy, W.E. Brownell, and A.A. Spector, Modeling Electrically Active Viscoelastic Membranes, PLoS One, 2012, 7, e37667.
  12. N. Nilsen, W.E. Brownell, S.X. Sun, and A.A. Spector, Effect of Membrane Mechanics on Charge Transfer through the Membrane Protein Prestin, Biomech. &Modeling in Mechanobiology 2012, 11, pp. 107-118.
  13. R.J. Powers, S. Roy, E.Atilgan, W.E. Brownell, S.X. Sun, P.G. Gillespie, and A.A. Spector, Stereocilia Membrane Deformation: Implications for the Gating Spring and Mechanotransduction Channel, Biophys. J., 2012, 102, pp. 201-210.
  14. Lau, W.E. Brownell, and A.A. Spector, Internal Forces, Tension, and Energy Density in Tethered Cellular Membranes, J. Biomechanics, 2012, 45, pp. 1326-1331.
  15. B. Harland, W. E. Brownell, A. A. Spector, and S.X. Sun, Voltage-Induced Bending and Electromechanical Coupling in Lipid Bilayers, Physical Review E, 2010, 81, Art 031907.
  16. K.R. Schumacher, A.S. Popel, B. Anvari, W.E. Brownell, and A.A. Spector, Computational Analysis of the Tether Pulling Experiment to Probe Plasma Membrane - Cytoskeleton Interaction in Cells Phys. Review E, 2009, 80, Art. 041905.
  17. S.X. Sun, B. Farrell, M.S. Chana, G. Oster, W.E. Brownell, and A.A. Spector, Voltage and Frequency-Dependence of Prestin-Associated Charge Transfer. J. Theoret. Biology. 2009, 260, pp. 137-144.
  18. A.M. Cheshire, B.E. Kerman, W.R. Zipfel, A.A. Spector, and D.J. Andrew, Kinetic and Mechanical Analysis of Live Tube Morphogenesis, Developmental Dynamics, 2008, 237, pp.2874-2888.
  19. K.R. Schumacher, A.S. Popel, B. Anvari, W.E. Brownell, and A.A. Spector, Modeling the Mechanics of Tethers Pulled from the Outer Hair Cell Membrane J. Biomech. Eng. , 2008, 130, art. 31007.
  20. Z. Liao, S. Feng,A.S. Popel, W.E. Brownell, and A.A. Spector, Outer Hair Cell Active Force Generation in the Cochlear Environment, Journ. Acoust. Soc. Am., 2007, 122, pp. 2215-2225.
  21. A.A. Spector, N. Deo, K. Grosh, J.T. Ratnanather, and R.M. Raphael, Electromechanical Models of the Outer Hair Cell Composite Membrane, J. Membrane Biol., 2006, 209, pp. 135-152.
  22. C.M. Nelson, R.P. Jean, J.L. Tan, W.F. Liu, N. J. Sniadecki, A.A. Spector, and C.S. Chen, Emergent Patterns of Growth Controlled by Multicellular Form and Mechanics, PNAS, 2005, 102, pp. 11594-11599 (see also the title on the front page of the journal and the comment by D.E. Ingber, pp 11571-11572 in the same issue).
  23. D.R. Murdock, S.A. Ermilov, A.A. Spector, A.S. Popel, W.E. Brownell, and B. Anvari, Effect of Chlorpromazine on Mechanical Properties of the Outer Hair Cell Plasma Membrane, Biophys. J., 2005, 84, pp. 4090-4095.
  24. Z. Liao, A.S. Popel, W.E. Brownell, and A.A. Spector, High-Frequency Force Generation in the Constrained Cochlear Outer Hair Cell, Journ. Soc. for Res. in Otolaryngology (JARO) 2005, 6, pp. 378-389.
  25. Z. Liao, A.S. Popel, W.E. Brownell, and A.A. Spector, Effect of Voltage-Dependent Membrane Properties on Active Force Generation in Cochlear Outer Hair Cell, Journ. Acoust. Soc. Am., 2005, 118, pp. 3737-3746.
  26. A.A. Spector and R. Tran-Son-Tay, Modeling in Cellular Biomechanics, The Biomedical Engineering Handbook, Editor-in-Chief J. D. Bronzino, CRC Press and IEEE Press, 3rd Edition, 2006, pp. 62-1 – 62-15.
  27. R.P. Jean, C.S. Chen, and A.A. Spector, Finite-Element Analysis of the Adhesion-Cytoskeleton- Nucleus Mechanotransduction Pathway During Endothelial Cell Rounding: Axisymmetric Model, J. Biomech. Eng., 2005, 127, pp. 594-600.
  28. A.A. Spector, Effectiveness, Active Energy Produced by Molecular Motors, and Nonlinear Capacitance of Cochlear Outer Hair Cell, J. Biomech. Eng., 2005, 127, pp. 391-399.
  29. A.A. Spector, A. S. Popel, R. A. Eatock, and W. E. Brownell, Mechanosensitive Channels in the Lateral Wall Can Enhance the Cochlear Outer Hair Cell Frequency Response. Annals Biomed. Eng., 2005, 23, pp. 991-1002 (see also the article by F. Sneiderman in the Johns Hopkins Gazette, 2004, 33, #25).
  30. Z. Liao, A.S. Popel, W.E. Brownell, and A.A. Spector, Modeling High-Frequency Electromotility of Cochlear Outer Hair Cell in Microchamber Experiment, Journ. Acoust. Soc. Am., 2005, 117, pp. 2147-2157.
  31. R. P. Jean, D. G. Gray, A. A. Spector, and C. S. Chen, Characterization of the Nuclear Deformation During Endothelial Cell Rounding, J. Biomech. Eng., 2004, 126, pp. 552-558.
  32. A.A. Spector and R. P. Jean, Modes and Balance of Energy in the Piezoelectric Outer Hair Cell Wall, J. Biomech. Eng., 2004, 126, pp. 17-25.
  33. A. Spector and R. P. Jean, Elastic Moduli of the Piezoelectric Cochlear Outer Hair Cell Membrane, Exp. Mech., 2003, 43, pp. 355-360.
  34. A. Spector, W. Brownell, and A.S. Popel, Effect of Outer Hair Cell Piezoelectricity on High- Frequency Receptor Potentials, Journ. Acoust. Soc. Am., 2003, 113, pp. 453-461.
  35. pector, M. Ameen, and R. A. Schmiedt, Modeling Three-Dimensional Deformation of Outer Hair Cells in the Cochlea, Biomechanics and Modeling in Mechanobiology, 2002, 1, pp. 125-135.
  36. A.A. Spector, M. Ameen, P.G. Charalambides, and A.S. Popel, Nanostructure, Effective Properties, and Deformation Pattern of the Cochlear Outer Hair Cell Cytoskeleton, J. Biomech. Eng., 2002, 124, pp. 180-187.
  37. A.A. Spector, M. Ameen, and A.S. Popel, Simulation of Motor-Driven Outer Hair Cell Electromotility, Biophys. J., 2001, 81, pp.11-24.
  38. W.E. Brownell, A.A. Spector, R.M. Raphael, and A.S. Popel, Micro- and Nanomechanics of the Cochlear Outer Hair Cell Wall, Annu. Rev. Biomed. Eng. 2001, 3, pp. 169-194.
  39. A.A. Spector, A Nonlinear Electroelastic Model of the Auditory Outer Hair Cell, Int. Journ. of Solids & Structures, 2001, 38, pp. 2115-2129.
  40. A.A. Spector, On the Mechanoelectrical Coupling in the Cochlear Outer Hair Cell, Journ. Acoust. Soc. Am., 2000, 107, pp. 1435-1441.
  41. A.A. Spector, Nonlinear Electroelastic Model for the Composite Outer Hair Cell Wall, Journ. of Oto-Rhino-Laryngology (paper invited for special issue Cochlear Mechanics), 1999, 61, pp. 287- 293.
  42. A.A. Spector, W.E. Brownell, and A.S. Popel, Mechanical and Electromotile Characteristics of Auditory Outer Hair Cell, Medical and Biological Engineering and Computing, 1999, 37, pp. 247-251.
  43. A.A. Spector, W.E. Brownell, and A.S. Popel, Nonlinear Active Force Generation by Cochlear Outer Hair Cells, Journ. Acoust. Soc. Am., 1999, 105, pp. 2414-2420.
  44. A.A. Spector, W.E. Brownell, and A.S. Popel, Elastic Properties of the Composite Outer Hair Cell Wall, Annals Biomed. Eng., 1998, 26, pp. 157-165.
  45. A.A. Spector, W.E. Brownell, and A.S. Popel, Analysis of the Micropipet Experiment with the
  46. Anisotropic Outer Hair Cell Wall, Journ. Acoust. Soc. Am., 1998, 103, pp. 1001-1006.
  47. A.A. Spector, W.E. Brownell, and A.S. Popel, Estimation of Elastic Moduli and Bending Stiffnesses of the Anisotropic Outer Hair Cell Wall, Journ. Acoust. Soc. Am., 1998, 103, pp. 1007-1011.
  48. S.P. Sit, A.A. Spector, A. Lue, A.S. Popel, and W.E. Brownell, Micropipette Aspiration of the Outer Hair Cell Lateral Wall, Biophys. J., 1997, 72, pp. 2812-2819.
  49. A.A. Spector, W.E. Brownell, and A.S. Popel, A Model for Cochlear Outer Hair Cell Deformations in Micropipette Aspiration Experiment: An Analytical Solution, Annals Biomed. Eng., 1996, 24, pp. 242-249.
  50. A.A. Spector and R.C. Batra, On Joints with Interfacial Cracks, Engineering Fracture Mechanics, 1996, 53, pp. 329-344.
  51. A.A. Spector and R.C. Batra, Rolling/Sliding of a Vibrating Elastic Body on an Elastic Substrate,
  52. Transactions ASME. Journal of Tribology, 1996, 118, pp. 147-152.
  53. A.A. Spector and R.C. Batra, On Contact Interaction between a Massive Body Moving on a Linear Elastic Half Space, Continuum Mechanics and Thermodynamics, 1995, 7, pp. 179-198.
  54. A.A. Spector and R.C. Batra, On the Motion of an Elastic Body Rolling/Sliding on an Elastic Substrate, Transaction ASME. Journal of Tribology, 1995, 117, pp. 308-314.
  55. A.A. Spector and R.C. Batra, Rolling/Sliding of an Elastic Body on a Deformable Layered Substrate, Int. Journal of Nonlinear Mechanics, 1994, 29, pp. 335-348.
  56. V.L. Rabinovich and A.A. Spector, Variational-Asymptotic Solution Method for Three- Dimensional Contact Problems with Edge-Effects, Mechanics of Solids (MTT), 1989, 24, pp. 51- 58.
  57. A.A. Spector, Qualitative Properties and Time Evolution of Three-Dimensional Contact Problems with Friction, Soviet Physics Dokladi, 1988, 33, pp. 638-640.
  58. A.A. Spector, Variational Method of Solving Three-Dimensional Contact Problems of Nonstationary Interaction between Elastic Solids with Friction, Applied Mathematics and Mechanics (PMM), 1987, 51, pp. 56-62.
  59. V.L. Rabinovich and A.A. Spector, Solution of Some Classes of Three-Dimensional Contact Problems with Unknown Boundary, Mechanics of Solids (MTT), 1985, 20, pp. 89-97.
  60. A.A. Spector, Variational Method of Solving Three-Dimensional Contact Problems of Nonstationary Interaction between Elastic Solids with Friction, Soviet Physics Dokladi, 1985, 30, pp. 1009-1011.
  61. R.V. Goldshtein and A.A. Spector, Variational Methods of Investigation of Three-Dimensional Mixed Problems for a Plain Cut in an Elastic Medium in the Presence of Slip and Adhesion of Its Surfaces, Applied Mathematics and Mechanics (PMM), 1984, 47, pp. 232-239.
  62. A.A. Spector, Variational Methods of Investigating Certain Classes of Three-Dimensional Problems of Contact between Elastic Bodies in the Presence of Friction, Soviet Physics Dokladi, 1982, 27, pp. 548-550.
  63. A.A. Spector, Some Three-Dimensional Static Contact Problems of Elasticity Theory with Slip and Adhesion, Mechanics of Solids (MTT), 1981, 16, pp.10-21.
  64. R.V. Goldshtein and A.A. Spector, Variational Estimates of the Solutions of Some Mixed Three- Dimensional Problems of Elasticity Theory with Unknown Boundary, Mechanics of Solids (MTT), 1978, 13, pp. 75-86.
  65. A.A. Spector, Variational Method of Investigating Contact Problems with Slip and Cohesion,
  66. Soviet Physics Dokladi, 1977, 22, pp. 530-532.
  67. A.A. Spector, Equilibrium Stability of an Elastic Bottom Vessel Containing Liquid, Moscow University Mechanics Bulletin (Vestnik MGU), 1973, 28, pp. 70-75.
  68. pector, Two Definitions of Equilibrium Stability for a Body with Liquid, Moscow University Mechanics Bulletin(Vestnik MGU), 1972, 27, pp. 27-29.
Book Chapters
  1. S.X. Sun, B. Farrell, M.S. Chana, S. Feng, G. Oster, W.E. Brownell, and A.A. Spector, Voltage and Frequency Dependence of Charge Transfer by Prestin: An Electro-Diffusion Model, in: Concepts and Challenges in the Biophysicsof Hearing eds. N.P. Cooper and D.T. Kemp, World Scientific, New Jersey, 2009, pp.385-390.
  2. J.S. Oghalai, A A. Spector, and C-H. Choi, Effect of Perilymph Osmolarity on Cochlear Amplifier, in Auditory Mechanisms: Processes and Models, eds F. Nuttall et al.,World Scientific, Singapore, 2006, pp. 41-48.
  3. Z. Liao, A.S. Popel, W.E. Brownell, and A.A. Spector, High-Frequency Active Force Generation in Constrained Cochlear Outer Hair Cells in Auditory Mechanisms: Processes and Models, eds F. Nuttall et al., World Scientific, Singapore, 2006, pp. 202-209.
  4. A.A. Spector, W. Brownell, and A.S. Popel, Piezoelectric Properties Enhance Outer Hair Cell High-Frequency Response, in Biophysics of the Cochlea: Molecules to Models Recent Developments in Auditory Mechanics, eds. A. Gummer et al., World Scientific, Singapore, 2002, pp. 79-85.
  5. A.A. Spector, M. Ameen, P.G. Charalambides and A.S. Popel, Computational Modeling of the Outer Hair Cell Cytoskeleton, in Recent Developments in Auditory Mechanics, eds. H. Wada et al., World Scientific, Singapore, 2000, pp. 307-313.
  6. A.A. Spector, Thermodynamic Potentials and Constitutive Relations for a Nonlinear Electroelastic Biological Membrane, in Symposium on the Mechanics of Electromagnetic Materials and Structures, eds. G.A. Maugin and J. Yang, IOS Press, Amsterdam, 1999, pp. 99- 109.
  7. A. Spector, A Nonlinear Electroelastic Model of the Cochlear Outer Hair Cell, in Applied Mechanics in the Americas, eds. C.R. Steele et al., American Academy of Mechanics, Rio de Janeiro, Brazil, 1999, v. 6, pp. 19-22.
  8. pector, W.E. Brownell, and A.S. Popel, An Elastic Composite Model of the Outer Hair Cell Wall, in Diversity in Auditory Mechanics, eds. E.R. Lewis et al., World Scientific Publishing, Singapore, 1997, pp. 608-614.
  9. J.T. Ratnanather, A.A. Spector, A.S. Popel, and W.E. Brownell, Is the Outer Hair Cell Wall Viscoelastic?, in Diversity in Auditory Mechanics, eds. E.R. Lewis et al., World Scientific Publishing, Singapore, 1997, pp. 601-607.
  10. pector, W.E. Brownell, and A.S. Popel, A Model of Elastic Properties of Cell Membranes, in Contemporary Research in Mechanics and Mathematics of Materials, eds. R.C. Batra and M.F. Beatty, International Center for Numerical Methods in Engineering, Barcelona, Spain, 1996, pp. 55-66.

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