Paul Eduard Sijens, PhD
Associate professor of Radiology

University Medical Center Groningen
Groningen, Netherlands
Phone: 31 50 3613534


1988 PhD Thesis: "31P NMR spectroscopy of tumors in the evalu­ation of respon­se to therapy" (Rijksuniversiteit Utrecht)
1983 Doctoraldegree in Chemistry (Rijksuniversiteit Utrecht)
1981   Candidate degree in Chemistry (Rijksuniversiteit Utrecht)
1977   Diploma Gymnasium (ThorbeckeLyceum Utrecht)


Paul E. Sijens, born in 1959 in the Netherlands, obtained his PhD in 1988.  Chapters of his thesis "31P NMR spectroscopy of tumors in the evalu¬ation of respon¬se to therapy" (Rijksuniversiteit Utrecht) were published in Cancer Research (2x), International Journal of Hyperthermia, NMR in Biomedicine (2x) and Radiology. After having worked as project scientist in Utrecht from 1983-1989, he did a postdoc at Cleveland Clinic Foundation in the group of  dr. Thian Ng (1989-1991). The resultant 31P and 19F MR spectroscopy studies were published in Cancer Research, Magnetic Resonance in Medicine, Magnetic Resonance Imaging and Investigative Radiology. From 1991-2000 he was in charge of clinical MR spectroscopy at Daniel den HoedCancerCenter (Department of Radiolo¬gy, Chairman: dr. M Oudkerk). Since 2000 he has been responsible for MRI research at the Department of Radiology, University Medical Center Groningen (prof. dr. R.A. Dierckx)In charge of experimental and preclinical MR imaging with main focus on neuro-, breast- cardio- and liver MR applications and on quantitative image analysis and segmentation. Since 2002 he has been associate professor at Rijksuniversiteit Groningen (RUG). Current functions include faculty membership of the EuropeanSchool of Radiology (ESOR), board membership of Research Foundation Flanders and numerous board memberships of scientific journals (deputy editor of J MagnReson Imaging). He is author of 125 international scientific papers cited 2182 times (Hirsch index 27).

Research Interest

Research interests: MRI, Perfusion, Diffusion, Metabolism, Neurology, Oncology

Scientific Activities

Awards and Honours
Jan 26, 2017 Koning Albert Gedenkpenning, Fonds voor Wetenschappelijk Onderzoek (FWO Vlaanderen), Brussels (2007).
July 2006 - Faculty Member, EuropeanSchool of Radiology (ESOR)
May 12, 1993 Sandoz  award
Aug.22, 1989 SMRM award for contribution at 8th Annual Meeting Society for Magnetic Resonance in Medicine, Amsterdam.
Oct.31, 1988 ESMO award because of a contribution at the 13th Con­gress of the European Society for Medical Oncology, Lugano
Jan. 2014- Principle investigator and leader of research line“Development and optimization of MRI technology”
2012-2014 Chairman of the Board of RUR (organizer of research meetings at UMCG Radiology)
Nov. 2002- Associateprofessor (Universitair Hoofddocent) at Rijksuniversiteit Groningen (RUG).
Nov. 2000- Head of MR imaging research at Department of Radiology, University Medical Center Groningen (prof. R.A. Dierckx)In charge of experimental and preclinical MR imaging with main focus on neuro-, cardio- and liver MR applications and on quantitative image analysis and segmentation.
1992-1993 Coordinator of multi-center clinical 1H MRS study (Albu­quer­que, Erlan­gen, Heidelberg, Minnea­polis, Naples, Passau, Rotterdam).
1991-2000 In charge of MR Spectroscopy at Daniel den Hoed Cancer Center (Department of Radiolo­gy, Chairman: M Oudkerk), Rotter­dam (Siemens Magne­tom SP4000 63/84 and Vision MR system equipped with 1.5/2T Helicon magnet).
1989-1991 Postdoc funded by the National Institutes of Health (NIH); responsible for multinu­clear NMR studies of therapy-induced changes in tumor metabo­lism (Cleveland Clinic Foundation, Divisi­on of Radio­logy; MR Research Center, Director: TC Ng)
1983-1989 Project scientist funded by Rijksuniversiteit Utrecht and Dutch Cancer Foundation (NKB); in charge of oncological NMR spectro­scopy studies (Universi­ty Hospital Utrecht, dept of Radiotherapy)
2016- present Course LCMM 3.1 Molecules for Mental Health, for medical students. One lecture on MRI/MRS, and 3 day parts on seminars  (meet the expert on imaging proposal, meet the expert on health advocacy and presentation of movies),
2008 - present International Student Congress of (Bio)Medical Sciences, leading oral and poster sessions on the topic “Radiology” and selecting session winners (annually)
2007-present "Snuffelstages." A couple of times a year an hour of MRI instruction to a student orienting him/herself on future study choices.
2006-present Session president in the annual International Student Congress of Medical Sciences held at UMCG, session "diagnostic imaging".
2006-2008 "Neurofysiology en hersenimaging", periodical (twice a year) exam for propadeuseLifescience and Technology (LS&T) students who followed these lectures of emeritus prof. D.Duifhuis.
2006   "Levensloop/Rode Draad) 1e semester levenswetenschappen": Principles of MRI canning
2005-present The annual BMT curriculum "Imaging techniques in Radiology", the MRI-part consisting of a lecture series on MRI, a  simulation session on  the PC, four sessions of practice of 1 and 1.5 tesla MRI systems. Every student turns in a report and MRI is an important part of the final "Imaging techniques in Radiology" exam.
2004-2006 Course MRI for BTR2 students: the clinical part: 6 day parts followed by an       exam (prior to 2004 this course was given by R.F.E. Wolf)
2004-present Course education radiology (given at lunchhourfor radiologists in training and MD's on projects). Topic: MRI
2003 Examinator in program "Klinischredeneren" trimester 3.1
2003-2004 Tutortrimester 3.1: Regeling en Ontregeling,
2002-present Research presentations at UMCG in the evening, "refereeravonden (contributing about once a year, for colleagues from radiology andother hospital departments, and MD's/PhD's in training)


  1. Wielema M, Dorrius MD, Dijkstra H, Langius E, de Bock GH, Oudkerk M, Sijens PE. High (2017) reproducibility of breast lesion ADC values based on fixed size and shape region of interest in diffusion weighted imaging.. J MagnReson Imaging (prepared)
  2. Grazzini I, Carbone SF, Fausto A, Lazzi S, Sijens PE, Mazzei MA; Volterrani L. (2017) Correlation between DWI-ADC values, measured in iliac crest and in L5 vertebral body, and histological cellularity in bone marrow biopsy in patients affected by lymphoma. (prepared)
  3. TriadyaksaP, Kuipers TJA, D’Antonoli TA, Overbosch J,PrakkenNHJ, Rook M, van Swieten M, OudkerkM, Sijens PE. (2017) Myocardium T1 quantification showing regional differences between median segmental pixel values.  (PlosOne, submitted)
  4. TriadyaksaP, PrakkenNHJ, Overbosch J, OudkerkM, Sijens PE. (2017) Comparison of the obustness of different T2* fitting methods in detecting myocardial iron deposition in bright blood multi-gradient echo cardiac magnetic resonance imaging. J MagnReson Imaging(prepared).
  5. Sijens PE, ter Horst HJ  (2017)Reply to correspondence by F. Groenendaalre: “Sijens et al. The prognostic value of proton magnetic resonance spectroscopy in term newborns treated with therapeutic hypothermia following asphyxia.Magnetic Resonance imaging 2017;42:82-87.”, Magnetic Resonance imaging (in Press).
  6. TriadyaksaP, PrakkenNHJ,Overbosch J, PetersRB, van SwietenM, OudkerkM, Sijens PE  92017) Semi-automated myocardial segmentation of bright-blood multi gradient echo images improves reproducibility of myocardial contours and T2* determination. MagnReson Mater Phy2017;30:239-254
  7. Sijens PE,Wischniowsky KB,ter Horst HJ. (2017) The prognostic value of proton magnetic resonance spectroscopy in term newborns treated with therapeutic hypothermia following asphyxia.  Magnetic Resonance imaging 2017;42:82-87.
  8. Dijkstra H, Wolff D, van Melle JP, Bartelds B, Willems TP, Hillege H, van den Berg AP, Ebels T, Berger RMF, Sijens PE. (2017) Diminished liver microperfusion in Fontan patients: a biexponential DWI study. PLoS One2017;12(3):e0173149(13 pages)
  9. Lunsing TJ, Strating K, de Koning TJ, Sijens PE. (2017) Diagnostic value of MRS-quantified brain tissue lactate level in identifying children with mitochondrial disorders.  EurRadiol;27:976-984.
  10. Dijkstra H, Handayani A,Kappert P, Oudkerk M, Sijens PE. (2017) Clinical proof relating the fast diffusion component in intravoxel incoherent motion (IVIM) modeled hepatic diffusion weighted imaging (DWI) to microperfusion as measured by perfusion MRI. MagnReson Imaging;38:47-53.
  1. Dijkstra H, Dorrius M, Wielema M, Pijnappel RM, Oudkerk M, Sijens PE.( 2016) Quantitative DWI implemented after DCE-MRI yields increased specificity for  BIRADS 3 and 4 breast lesions. J MagnReson Imaging;44:1642-1649.
  2. Pelgrim GJ, Handayani A, Dijkstra H, Prakken NHJ, Slart R, Oudkerk M, van Ooijen PMA, Vliegenthart R, Sijens PE. (2016) Quantitative  myocardial perfusion with dynamic contrast-enhanced imaging in MRI and CT: theoretical models and current implementation. BiomedResIntern;:1734190
  3. Viddeleer AR, Sijens PE, van Ooijen PMA, Kuypers PDL, Hovius SER, Oudkerk M (2016) Quantitative STIR of muscle for monitoring nerve regeneration. JMagnReson Imaging;44:401-410.
  4. Dijkstra H, Dorrius M, Wielema M, Jaspers K, Pijnappel RM, Oudkerk M, Sijens PE (2016) Semi-automated quantitative intravoxel incoherent motion analysis and its implementation in breast diffusion-weighted imaging. J MagnReson Imaging;43:1122-31.
  5. Triadyaksa P, Handayani A, Dijkstra H, Aryanto YE, Pelgrim GJP, Willems TP, Oudkerk M, Sijens PE. (2016) Contrast-optimized composite image derived from multigradient echo cardiac magnetic resonance imaging improves reproducibility of myocardial contours and T2* measurement. MagnReson Mater Phy;29:17-27.
  6. Wolff D, van Melle JP, Dijkstra H,Bartelds B, Willems JP, Hillege H, van den Berg AP,Ebels T,Sijens PE, Berger RFM. (2016) The Fontan circulation and the liver: a magnetic resonance diffusion-weighted imaging study. Int J Cardiol  :202: 595-600
  1. Handayani A, Dijkstra H, Pelgrim P, Triadyaksa P, van Ooijen PMA, Schoepf UJ, Oudkerk M, Vliegenthart R,Sijens PE. (2015) Inter-model agreement of myocardial blood flow estimation from MR first pass perfusion imaging in patients with coronary artery disease. Invest Radiol 2015;50:275-282.
  2. de Groot MJ, Sijens PE, Reijngoud D-J, de Valk HJ, Paans AM, van Spronsen FJ (2015) Phenylketonuria: elevated brain phenylalanine strongly relates to reduced cerebral protein synthesis. J Cereb Blood Flow Metab;35:200-205.
  1. Dijkstra H, Jaspers K, Handayani A,Kappert P, Oudkerk M, Sijens PE. (2014) Clinical implications of fatty liver on hepatic diffusion-weighted imaging studied in healthy subjects. PLoS One ;9(2):e87926 (8 pages).
  2. Dorrius M, Dijkstra H, Oudkerk M, Sijens PE (2014) Diffusion weighted imaging of breast lesions: a systematic review and meta-analysis. EurRadiol; 24: 2835-2847.
  1. Handayani A, Sijens PE, Lubbers DD, Triadyaksa P, Oudkerk M,van Ooijen PMA. (2013) Influence of the choice of software packages on the outcome of semi-quantitative MR myocardial perfusion analysis. Radiology; 266: 759-765. 
  2. Freling HG, Pieper PG, Vermeulen KM, van Swieten JM, Sijens PE, van Velthuisen DJ, Willems TP (2013) Improved cardiac MRI volume measurements in patients with tetralogy of Fallot by independent end-systolic and end-diastolic phase selection. PLoS One; 8(1): e55462 (5 pages).
  1. Lubbers DD, Rijlaarsdam-Hermsen D, Kuijpers D, Kerkhof M, Sijens PE, van Dijkman PRM, Oudkerk M (2012) Performance of adenosine “stress-only” perfusion MRI in patients without a history of myocardial infarction: a clinical outcome study.  Int J Cardiovasc Imaging; 28: 109-115   
  2. Dorrius MD, Pijnappel RM, Sijens PE, Jansen-van der Weide MC, Oudkerk M (2012) The negative predictive value of breast magnetic resonance imaging in noncalcified BIRADS 3 lesions. Eur J Radiol; 81: 209-213
  3. Dorrius MD, Pijnappel RM, Jansen-van der Weide MC, Jansen L, Kappert P, Oudkerk M, Sijens PE (2012) The added value of quantitative multi-voxel MR spectroscopy in breast magnetic resonance imaging. EurRadiol;22: 915-922.
  4. Dijkstra H, Baron P, Kele P, Dorrius MD, Kappert P, Oudkerk M, Sijens PE (2012)Effects of microperfusion in hepatic diffusion weighted imaging. EurRadiol; 22: 891-899.
  5. van Doormaal PJ, Meiners LC, ter Horst HJ, van der Veere CN, Sijens PE (2012) The prognostic value of multivoxel magnetic resonance spectroscopy determined metabolite levels in white and grey matter brain tissue for adverse outcome in term newborns following perinatal asphyxia. EurRadiol; 22: 772-778.
  6. Viddeleer AR, Sijens PE, van Ooijen PMA, Kuypers PDL, Hovius SER, Oudkerk M  (2012) Sequential MR imaging of denervated and reinnervated skeletal muscle, as correlated to functional outcome. Radiology;264: 522-530.
  1. Viddeleer AR, Sijens PE, van Ooijen PMA, Kuypers PDL, Hovius SER, Oudkerk M (2011)MR intensity measurements of non-denervated muscle in patients following severe forearm trauma. NMR Biomed;24:895-901  
  2. Determination of choline concentrationin breast lesions: quantitative multivoxel 1H MR spectroscopy as a promising non-invasive assessment tool to exclude benign lesions.
  3. Dorrius MD, Pijnappel RM, Jansen-van der Weide MC, Jansen L, Kappert P, Oudkerk M, Sijens PE. (2011) Radiology; 259: 695-703.
  4. Gagarina N, Irwan R, Gordina G, Fominykh F, Sijens PE. (2011) Image quality in reduced dose coronary CT angiography. AcadRadiol; 18: 984-990.
  1. Baron P, Dorrius MD, Kappert P, Oudkerk M, Sijens PE. (2010) Diffusion-weighted imaging of normal fibroglandular breast tissue: influence of microperfusion and fat suppression technique on the apparent diffusion coefficient. NMR Biomed  ;23: 399-405 .
  2. Sijens PE, Dorrius MD, Kappert P, Baron P, Pijnappel RM, Oudkerk M (2010) Quantitative multivoxel proton CSI of the breast. Magn Reson imaging; 28: 314-319 
  3. Sijens PE, Dorrius MD (2010) Spectroscopic imaging in breast cancer. ImagingDecis MRI  ;13:122-125
  4. Sijens PE (2010) Response to article by Andrés Server, et al., “Proton magnetic resonance spectroscopy in the distinction of high-grade cerebral gliomas from single metastatic brain tumors. Acta Radiol;51:316-325”, Acta Radiol 2010;51:326-328
  5. Sijens PE, Edens MA, Bakker SHL, Stolk RP (2010) MRI determined fat content of human liver, pancreas and kidney. World J Gastroenterol;16;1993-1998  
  6. Sijens PE. (2010) Liver magnetic resonance imaging: state of the art. World J Gastroenterol;16:1558-1559 
  1. Verbruggen KT, Meiners LC, Sijens PE, Lunsing RJ, van Spronsen FJ, Brouwer OF (2009) Magnetic resonance imaging and  proton magnetic resonance spectroscopy in the diagnostic evaluation of developmental delay. Eur J PediatrNeurol; 13: 181-190.
  2. Dikkers R, Greuter MJW, Kristanto W, van Ooijen PMA, Sijens PE, Willems TP, Oudkerk M (2009) The assessment of image quality of 64-row dual source versus single source CT coronary angiography on heart rate: a phantom study.  Eur J Radiol; 70: 61-68.
  3. Olthof  AW, Sijens PE, Kreeftenberg HG, Kappert P, van der Jagt EJ, Oudkerk M (2009) Non-invasive liver iron concentration measurement by MRI: comparison of two validated protocols. Eur J Radiol;71: 116-212.
  4. Viddeleer AR, Sijens PE, van Ooijen PMA, Kuypers PDL, Hovius SER, Oudkerk M (2009) Long term reproducibility of phantom image intensities in nonouniformity corrected STIR-MRI examinations of skeletal muscle. MagnReson Mater Phy;22:201-209.
  5. EdensMA, van OoijenPMA, PostWJ, HaagmansMJF, Kristanto W, SijensPE,van der JagtEJ, StolkRP (2009) Ultrasonography to quantify hepatic fat content: validation by 1H Magnetic Resonance Spectroscopy. Obesity;17:2239-2244.
  6. Sijens PE, Westerlaan HE, de Groot JC, Boon M, Potze JH, van Spronsen FJ, Lunsing RJ, Oudkerk M (2009)  MR spectroscopy of diffusion tensor imaging of the brain in Sjögren-Larsson syndrome. Mol Genet Metab;98:167-171.
  7. Sijens PE. (2009) Parametric exploration of the liver by magnetic resonance methods. EurRadiol;19:2594-2607
  8. Sijens PE, Lubbers DD  (2009) Comparison of two fast MRI methods for perfusion imaging of the heart. Imaging Decis MRI;13:43-48.
  9. Verbruggen KT, Maurits NM, van Spronsen FJ, Brouwer OF, Sijens PE. (2009) Quantitative multivoxel proton spectroscopy of the brain in developmental delay. J MagnReson Imaging;30: 716-721.
  1. Sijens PE, Oudkerk M,Letter to the Editor re: Richard J. Maddock et al. (2008) “Brain lactate responses during visual stimulation in fasting and hyperglycemic subjects: a proton magnetic resonance study at 1.5 tesla” [Psych Res Neuroim; 148:47-54]. Psych Res Neuroim2008;162: 173-174.
  2. Irwan R, Edens MA, Sijens PE. (2008) Assessment of the variations in fat content in normal liver using a fast quantification: MR imaging method in comparison with results obtained by spectroscopic imaging.  Eur Radiol 2008;18:806-813.
  3. Sijens PE, Mostert JP, Irwan R, Potze JH, Oudkerk M, De Keyser, J. (2008) The impact of fluoxetine on the human brain in multiple sclerosis as quantified by 1H MR Spectroscopy and diffusion tensor imaging: preliminary findings.
  4. Psych Res  Neuroim;174: 274-282.
  5. Sijens PE, SmitGPA, Rödiger LA, van Spronsen FJ, Oudkerk M, Rodenburg RJ, Lunsing RJ. (2008) MR Spectroscopy of the brain in Leigh syndrome. Brain Dev;30:579-83.
  6. Borra R, Lautamäki R, Parkkola R, Komu M, Sijens PE, Hälsten K, Bergman J, Iozzo P, Nuutila P (2008) Inverse association between liver fat content and hepatic glucose uptake in patients with type 2 diabetes. Metab-ClinExper;57:1445-1451.
  7. Sijens PE, Rödiger LA, Meiners LC, Lunsing RJ (2008) 1H magnetic resonance spectroscopy in monocarboxylate transporter 8 gene deficiency. J ClinEndocrinMetab;93:1854-9.
  8. Sijens PE, Alkefaji H, Lunsing RJ, van Spronsen FJ, Meiners LC, Oudkerk M, Verkade HJ (2008) Quantitative multivoxel MR spectroscopy of the brain in children with acute liver failure. EurRadiol;18:2601-2609.
  9. Irwan R, de Vries HBK, Sijens PE (2008) The impact of scan length on the exposure levels in 16-row MSCT and  64-row MSCT: a phantom study. AcadRadiol 15: 1142-7.
  1. Olthof AW, Sijens PE, Kreeftenberg HG, Kappert P, Irwan R, van der Jagt EJ, Oudkerk M (2007) The impact of  hematologic disease and inflammation on the relationship between liver iron concentration as determined by magnetic resonance imaging and serum ferritin concentration. MagnReson Imaging; 25: 228-231.
  2. Irwan R, Lubbers DD, van der Vleuten PA, Kappert P, Gotte MJ, Sijens PE (2007) Parallel imaging for first-pass myocardial perfusion. MagnReson Imaging;5:678-683.
  3. Sijens PE, Fock JM, Meiners LC, Potze JH, Irwan R, Oudkerk M (2007) MR spectroscopy and diffusion tensor imaging of the brain in congenital muscular dystrophy with merosin deficiency: metabolite level decreases, fractional anisotropy decreases, and apparent diffusion coefficient increases in the white matter. Brain Dev;19:317-321.
  4. Verbruggen KT, Knijff WA, Lunsing RJ, Hordijk R, Sijens PE, Verhoeven NM, Salomons GS, Goorhuis- Brouwer SM, van Spronsen FJ (2007) GAMT deficiency causing global developmental delay: differences between formal testing and clinical observation. Eur J Pediatr;166:921-925.
  5. Verbruggen KT, Sijens PE, Schulze A, Lunsing RJ, Jacobs C, Salomons GS, van Spronsen FJ (2007) Successfull treatment of a guanidinoacetate methyltransferase deficient patient: findings with relevance to treatment strategy and pathofysiology. Mol Genet Metab;91:294-296.
  6. van Oostrum JCH, Sijens PE, Roos RAC, Leenders KL (2007) 1H magnetic resonance spectroscopy in preclinical  Huntingtondisease. Brain Res;1168;67-71.
  7. Sijens PE, Heesters MAAM, Enting RH, Potze JH, Irwan R, Meiners LC, Oudkerk M (2007) Diffusion tensor imaging and chemical shift imaging assessment of heterogeneity in astrocytoma under temozolomide chemotherapy. Cancer Invest;25:706-710 
  1. Sijens PE, Mostert JP, Oudkerk M, De Keyser J (2006) 1H MR spectroscopy of the brain in multiple sclerosis subtypes with analysis of the metabolite concentrations in gray and white matter: initial findings. EurRadiol; 16: 489-495  3.967
  2. Sijens PE, Irwan R, Potze JH, Mostert JP, De Keyser J, Oudkerk M (2006) Relationships between brain water content and diffusion tensor imaging parameters  (apparent diffusion coefficient and fractional anisotropy) in multiple sclerosis. EurRadiol; 16: 898-904.
  3. Den Heijer T, Sijens PE, Prins ND, Hofman A, Koudstaal PJ, Oudkerk M, Breteler MMB (2006) MR spectroscopy of brain white matter in the prediction of dementia. Neurology; 66: 540-544.
  4. Sijens PE, Reijngoud DJ, Soorani-Lunsing RJ, Oudkerk M, van Spronsen FJ (2006) Cerebral 1H MR spectroscopy showing elevation of brain guanidinoacetate in argininosuccinate lyase deficiency. Mol Genet Metab; 88;100-102.
  5. Sijens PE, Smit GP, Meiners LC, Oudkerk M, van Spronsen FJ (2006) Cerebral 1H MR spectroscopy revealing white matter NAA decreases in glutaricaciduria type I. Mol Genet Metab; 88: 285-289.
  6. van Spronsen FJ, Reijngoud DJ, Verhoeven NM, Soorani-Lunsing RJ, Jacobs C, Sijens PE (2006) High cerebral guanidinoacetate and variable creatine concentrations in argininosuccinante synthetase and lyase deficiency. Mol Genet Metab; 89: 274-276.
  7. Irwan R,  Russel IK, Sijens PE (2006) Fast 3D coronary artery contrast-enhanced magnetic resonance angiography with magnetization transfer contrast, fat suppression and parallel imaging as applied on an anthropomorphic moving heart phantom. Magn Reson Imaging; 24: 895-902.
  8. Mostert JP, Sijens PE, Oudkerk M, De Keyser J (2006) Fluoxetine increases cerebral white matter NAA/Cr ratio in patients with multiple sclerosis. Neurosci Lett; 402: 22-24.
  9. Sijens PE, Gieteling EW, Meiners LC, Sival DA, Potze JH, Irwan R, Oudkerk M (2006) Diffusion tensor imaging and magnetic resonance spectroscopy of the brain in a patient with Sturge-Weber syndrome. Acta Radiol;47: 972-976.
  10. Sijens PE, Smit GP, Borgdorff MAJ, Kappert P, Oudkerk M (2006) Multiple voxel 1H MR spectroscopy of phosphorylase-b kinase deficient patients (GSD IXa) showing an accumulation of fat in the liver that resolves with aging. J Hepatol; 45: 851-856.
  1. Boucard CC, Mostert JP, Cornelissen FW, De Keyser J, Oudkerk M, Sijens PE (2005) Visual stimulation, 1H MR spectroscopy and fMRI of the visual pathways. Eur Radiol; 15: 47-52.
  2. Mostert JP, Sijens PE, Oudkerk M, De Keijser J (2005) 1H magnetic resonance spectroscopy of the internal capsule in human brain: a feasibility study to detect lactate following contralateral motor activity. EurRadiol;15: 1349-1352.
  3. Sijens PE, Irwan R, Potze JH, Mostert JP, De Keyser J, Oudkerk M (2005) Analysis of the human brain in primary progressive multiple sclerosis with mapping of the of spatial distributions using 1H MR spectroscopy and diffusion tensor imaging. Eur Radiol; 15: 1686-1693.
  4. Sijens PE, Verbruggen  KT, Meiners LC, Soorani-Lunsing RJ, Rake JP, Oudkerk M (2005) 1H chemical shift imaging of the brain in guanidino methyl transferase deficiency, a creatine dificiency syndrome; guanidinoacetate accumulation in the gray matter. Eur Radiol; 15: 1923-1926.
  5. Sijens PE, Boon M, Meiners LC, Brouwer OF, Oudkerk M (2005) 1H chemical shift imaging and diffusion weighted imaging in  vanishing white matter disease. Eur Radiol; 15: 2377-2379.
  6. Oudesluijs GG, Hordijk R , Boon M, Sijens PE, Hennekam RCM (2005) Plantar lipomatosis, unusual facies and developmental delay: confirmation of Pierpont syndrome. Am J Med Genet A.;137: 77-80.
  7. Irwan R, SijensPE, Potze JH, Oudkerk M (2005) Correlation of proton MR spectroscopy and diffusion tensor brain MR imaging. Magn Reson Imaging; 23: 851-858.
  8. Sijens PE, Verbruggen KT, Oudkerk M, van Spronsen FJ, Soorani-Lunsing RJ (2005) 1H MR spectroscopy of the brain in Cr transporter defect. Mol Genet Metab86: 421-422.
  9. Sijens PE, Oudkerk M (2005) Clinical magnetic resonance spectroscopy.Imaging Decis MRI; 9: 39-48.
  10. Sijens PE (2005) Combining new methods – MR spectroscopy, functional MRI, diffusion tensor imaging. Imaging DecisMRI 9: 23-38.
  11. Sijens PE (2005) 1H magnetic resonance spectroscopy of the brain in pediatrics: the diagnosis of creatine deficiencies. ImagingDecis MRI; 9: 14-18.
  1. Sijens PE, Oudkerk M, Reijngoud DJ, Leenders KL, de Valk H, van Spronsen FJ (2004) 1H MR chemical shift imaging detection of phenylalanine in patients suffering from   phenylketonuria (PKU). Eur Radiol  ;14: 1895-900.
  1. Sijens PE, den Heijer T, Origgi D, Vermeer SE, Breteler MMB, Hofman A, Oudkerk M (2003)  Brain MR spectroscopy at a supraventricular plane showing changes with aging that differ between women and men. Radiology; 226: 889-896.
  1. Leij-Halfwerk S, Agteresch HJ, Sijens PE, Dagnelie PC (2002) Adenosine triphosphate infusion increases liver energy status in advanced lung cancer patients: an in vivo 31P magnetic resonance spectroscopy study. Hepatology; 35: 421-424.
  2. Sijens PE, Oudkerk M. Correspondence re: Bentzus M, Warmuth-Metz M, Burger R, Klein R, Tonn JC, Solymosi L (2002) ”Diagnosing dural metastases: the value of 1H magnetic resonance spectroscopy”. Neuroradiology 43:285-289,2001. Neuroradiology;44:275-27.
  3. Sijens PE, Oudkerk M. Correspondence re: Wells PS, Abderson DR, Rodger M, Stiell I, Dreyer JF, Barnes D, Forgie M, Kovacs G, Ward J, Kovacs MJ. (2002) “Excluding pulmonary embolism at the bedside without diagnostic imaging: management of patients with suspected pulmonary embolism presenting to the emergency department by using a simple clinical model and D-dimer. Ann Intern Med 135: 98-107,2001. Ann Intern Med;136: 781.
  4. Sijens PE, Oudkerk M (2002) 1H Chemical shift imaging characterization of human brain tumor and edema. Eur Radiol12:2056-2061.
  1. Sijens PE, Oudkerk M. Rebuttal to: Michiels JJ, Perrier A, Bounameaux H (2001) Should a normal D-dimer rule out angiographic pulmonary embolism or unfavorable putcome in patients left untreated?  ThrombHaemost; 85: 753-754.
  2. Sijens PE, den Heijer T, de Leeuw FE, de Groot JC, Achten E, Heijboer RJJ, Hofman A, Breteler MMB, Oudkerk M (2001) MR spectroscopy detection of lactate and lipid signals inthe brains of healthy elderly people. EurRadiol;11:1495-1501.
  3. Sijens PE, Oudkerk M (2001) Exclusion of pulmonary embolism using quantitative plasma D-dimer assays (Review). Clin Lab;47:321-326.
  4. Sijens PE, den Heijer T, de Leeuw FE, de Groot JC, Achten E, Heijboer RJJ, Hofman A, Breteler MMB, Oudkerk M (2001) Human brain 1H chemical shift imaging at age 60-90: An analysis of the causes of the observed sex differences in Brain Metabolites. Invest Radiol; 36:597-603.
  5. Sijens PE, Oudkerk M, Berghout A, van Beek EJR, van Ingen HE, Kemperman H (2001) Comparison of a quantitative latex and of a quantitative ELISA D-dimer Assay in the Exclusion of Segmental and Subsegmental Pulmonary Embolism. ThrombHaemost 86:1580-1582.
  6. Marsman JWP, Peters A, Oudkerk M, Michiels JJ, Pattynama PM, van Beek EJR, Sijens PE (2001) Guideline "deep venous thrombosis and pulmanary embolism": revision of earlier versions (multiple letter). Ned Tijdschr Geneeskd;145: 256-258.
  7. Jingtao M, Yuesong Y, Zhengyu L, Weiming C, Yonghao T, Sijens PE, Xianqiao T (2001)  Neovascular perfusion in lung cancer: qualitative and quantitative study using MR perfusion imaging.              Imaging Decis MRI;5:1-6.
  1. Leij-Halfwerk S,  Dagnelie PC, van den Berg JWO Wilson JHP, Sijens PE (2000) Hepatic sugar phosphate levels and rate of gluconeogenesis in lung cancer:simultaneous turnover measurements and 31P magnetic resonance spectroscopy in vivo. ClinSci 98:167-174.
  2. Leij-Halfwerk S, van den Berg JWO, Sijens PE, Wilson JHP, Oudkerk M, Dagnelie PC (2000) Altered hepatic gluconeogenesis during L-alanine infusion in weight losing lung cancer patients as observed by 31P MR spectroscopy and turnover measurements. Cancer Res 60: 618-623.
  3. Leij-Halfwerk S, Dagnelie PC, Kappert P, Oudkerk M, Sijens PE (2000) Decreased hepatic energy and phosphorylation status in the liver of advanced lung cancer patients with weight loss. J.Hepatol 32:887-892.
  4. Sijens PE, van Ingen HE, van Beek EJR, Berghout A, Oudkerk M (2000) Rapid ELISA assay for plasma D-dimer in the diagnosis of segmental and subsegmental pulmonary embolism; a comparison with pulmonary angiography.Thromb Haemost 84: 156-159.
  1. Sijens PE, Oudkerk M, de Leeuw FE, de Groot JC, Achten E, Heijboer RJJ, Hofman A, Breteler MMN (1999) H chemical shift imaging of the human brain at age 60-90 reveals meta­bo­lic differ­ences between women and men. MagnReson Med 1999; 42:24-31.
  2. Dagnelie PC, Sijens PE, van den Berg JWO, van Dijk P, Kraus DJA, Planting AST, Wilson JHP, Oudkerk M (1999) Abnormal liver metabolism in cancer patients detected by 31P MR spectroscopy. NMR Biomed 1999; 12:535-544.
  1. Sijens PE, Dagnelie PC, Halfwerk S, van Dijk P, Wicklow K, Oudkerk M (1998) Understanding the discrepancies between 31P MR spectroscopy assessed liver metabolite concentrations from different institutions. MagnReson Imaging 1998; 16: 205-211.
  2. Sijens PE (1998) Phosphorus (31P) MR spectroscopy in the treatment of human extremity sarcomas: a review.NMR Biomed 11: 341-353.
  3. Sijens PE, Oudkerk M, van Dijk P, Levendag PC, Vecht ChJ (1998) H MR spectroscopy monitoring of changes in choline peakarea and line shape after Gd-contrast administration. MagnReson Imaging 16:1273-1280.
  1. Sijens PE, van den Bent MJ, Nowak PJCM, van Dijk P, Oudkerk M (1997) H Chem­ical shift imaging reveals loss of brain tumor choline signal after ad­ministration of Gd-contrast agent. MagnReson Med 37:222-225.
  2. Sijens PE, BaldwinNJ, Ng TC (1997) P MR Spectroscopy detection of response predictive NTP decrease in irradiated RIF-1 tumors. Invest Radiol 32:39-43.
  3. Sijens PE, van den Bent MJ, Oudkerk M. Phosphorus (1997) (31P) MR spectroscopy of metastatic tumors located in the spine region. Invest Radiol; 32:344-350.
  4. van Dijk P, Sijens PE, Schmitz PIM, Oudkerk M (1997) Gd-enhanced MR imaging of brain metastases: contrast as a function of dose and lesion size. MagnReson Imaging 15:535-541.
  1. Sijens PE, Levendag PC,­ Vecht ChJ, van Dijk P, Oudkerk M (1996) H MR spectros­copy detection of lipids and lactate in metastatic brain tumors. NMR Biomed 9:65-71.
  1. Sijens PE. Correspondence re: Kang H, et al (1995) P changes as a measure of therapy response in human osteosarcomas implanted into nude mice (Magn Reson Imaging 1994;12:935-943). MagnReson Imaging 13:495-496,499.
  2. Oudkerk M, Sijens PE, van Beek EJR, Kuijpers DJA (1995) Safety and efficacy of Dotarem (Gd-DOTA versus Magnevist (Gd-DTPA) in MRI of the central Nervous system. Invest Radiol 30:75-78.
  3. Sijens PE, van Dijk P, Dagnelie PC, Oudkerk M (1995) Non-T1 weighted P MR chemical shift imaging of the human liver. MagnReson Imaging 13:621-628.
  4. Sijens PE, Knopp MV, Brunetti A, Wicklow K, Alfano B, Bachert P, Sanders JA, Stillman AE, Kett H, Sauter R, Oudkerk M.H MR spectroscopy in patients with metastatic brain tumors: a multi-center study. Magn Reson Med 33:818-826.
  5. Sijens PE, Vecht CJ, Levendag PC, van Dijk P, Oudkerk M. (1995)H MR spectroscopy follow-up after radiotherapy of human brain cancer: unexpected inverse correlation between the changes in tumor choline level and post-Gd MRI contrast. Invest Radiol 12:738-744.
  6. Sijens PE, Eggermont AMM, van Dijk P, Oudkerk M (1995) Phosphorus MR spectroscopy in early assessing the efficacy of single-dose TNF-a isolated limb perfusion. NMR Biomed 8:215-224.
  1. Sijens PE, van Dijk P, Oudkerk M Correlation between choline level and Gd-DTPA enhancement in patients with brain metastases of mammary carcinoma. MagnReson Med 32:549-555.
  1. Sijens PE. Editors: P Spinelli, M Dal Fante, R Marchesini (1993) Photodynamic therapy and biomed­ical lasers: International Congress Series Vol 1011. Eur J Radiol 17: 139-140.
  1. Sijens PE, Ng TC. Thymidine (1992) Modulated 5-fluorouracil metabolism in liver and RIF-1 tumors studied by F magnetic resonance spectroscopy. MagnReson Imaging 10:385-392.
  1. Sijens PE, Huang Y, Baldwin NJ, Ng TC (1991) F MRS studies of the metabolism of 5-fluorouracil in murine RIF-1 tumors and liver. Cancer Res 51:1384-1390.
  2. Sijens PE, Baldwin NJ, Ng TC (1991) Multinuclear NMR investigation of the metabolic response of the murine RIF-1 tumor to 5-fluorouracil chemotherapy. MagnReson Med 19:373-385.
  3. Sijens PE, Oudkerk M, Stoter G. (1991)MR spectroscopie: nieuwe mogelijkheden voor het stadieren van tumoren en het beoordelen van respons op therapie. Ned TijdschrGeneeskd 135: 361-366.
  1. Scheiber C, Kiss R, de launoit Y, Sijens PE, Fruhling J (1990) Influence of hormono- and/or chemotherapy on the MXT mouse mammary tumor as monitored by P MRS. Eur J Cancer 26:241-251.
  2. Sijens PE, de Jong WH, van Echteld CJA, Seijkens D, de Groot G, van Rijssel RH, van der Linden AMJ, Lagendijk JJW, Neijt JP. (1990) P magnetic resonance study of doxorubicin and cisplatin induced changes in tumor metabolism in rats with a cisplatin-sensitive or -resistant immunocytoma. NMR Biomed 3:124-131.
  1. Sijens PE, Bovee WMMJ, Koole P, Schipper J. (1989) Phosphorus NMR study of the response of a murine tumor to hyperthermia as a function of treatment time and temperature.
  2. Int J Hyperther 5:351-357.
  3. Sijens PE, van Echteld CJA, Neijt JP, Schipper J, Dunki Jacobs PB, de Graaf PW, Seijkens D (1989) P NMR study of the impact of dietary manipulation on tumor metabolism and response to methotrexate. MR Biomed 2:12-18.
  1. Correspondence re: Steen RG, et al (1988) In vivo P nuclear magnetic resonance spectroscopy of subcutaneous 9L gliosarcoma: effects of tumor growth and treatment with 1,3-bis(2 chloroethyl)-1-nitrosourea on tumor bioenergetis and histology (Cancer Res 48: 676-681,1988). Bovee WMMJ. Cancer Res 48:5610-5611.
  2. Sijens PE, Wijrdeman HK, Moerland MA, Bakker CJG, Vermeulen JWAH, Luyten PR. Human breast cancer in vivo: H &P MR spectroscopy at 1.5T. Radiology 169:615-620.
  1. Sijens PE, Bovee WMMJ, Seijkens D, Koole P, Los G, van Rijssel RH. (1987)Murine mammary tumor response to hyperthermia and radiotherapy evaluated by in vivo P NMR spectroscopy. Cancer Res 47:6467-6473.
  1. Sijens PE, Bovee WMMJ, Seijkens D, Los G, Rutgers D. (1986)In vivo P NMR study of the response of a murine mammary tumor to different doses of gamma-radiation. Cancer Res 46: 1427-1432.
  1. Rietveld A, Sijens PE, Verkleij AJ, de Kruijff B (1983) Interaction of cytochrome c and its precursor apocytoch­rome c with various phospholip­ids. EMBO J 2: 907-913.
Book chapters and other publications
  1. Sijens PE (2015) Assessing fatty liver with MRS. In: Handbook of magnetic resonance spectroscopy in vivo: MRS theory, practice and applications.P.A. Bottomley and J.R. Griffiths ( editors). John Wiley & Sons Ltd., Chichester,, UK, pp773-782. eMagRes, vol.4: 497-504.
  2. Sijens, PE (2014) Molecular imaging using magnetic resonance spectroscopy in neurology: the past, the present, and the future. In: PET and SPECT in oncology, RAJO Dierckx, A Otte, EFJ de Vries, A van Waarde and KL Leenders editors, Springer, Heidelberg, pp 149-169.
  3. Kappert P, Sijens PE, Oudkerk M MR spectroscopie. Gamma 2005;12:2-9.
  4. PE Sijens, M Oudkerk MR Spectroscopy. In: Magnetism in Medicine, a Handbook. W. Andrä and JH Nowak editors, Wiley-VCH, Berlin 1998, chapter 3.2.3 pp 373-394.
  5. PC Dagnelie, S Halfwerk, PE Sijens, JWO van den Berg, GR Swart, P van Dijk, JHP Wilson,
  6. M Oudkerk. (1997) Cancer cachexia and gluconeogenesis: etiologic and prognostic studies by 31P MR spectrosco­py and stable isotope tracers.In: Advances in MRI, M. Oudkerk and R.R. Edelman editors, Blackwell Science, Berlin, pp 263-266.
  7. PE Sijens, P van Dijk, M Oudkerk 1997 H MR spectroscopy and Gd-enhanced MRI of human brain tumors and assessment of the changes after radiotherapy. In: Advances in MRI, M. Oudkerk and R.R. Edelman editors, Blackwell Science, Berlin, pp 227-233.
  8. R Mathur-de Vré, JD de Certaines, PE Sijens, P Styles (1992) Test substances. In: Tissue characterization by magnetic resonance spectroscopy and imaging, F. Podo and J.S. Orr editors, Instituto Superiore di Sanità, Rome, , pp 105-106.
  9. PE Sijens (1991) The metabolism of 5-fluorouracil in murine RIF-1 tumors and liver investigated by 19F MRS. Eurospin Quarterly 26: 87.
  10. PE Sijens (1990) Determination of tissue pH from the NMR spectra of 5-fluorouracil (5FU) and its metabol­ites. Texas A & M University Newsletter 387: 52.
  11. PE Sijens (1990) 19F and 31P MRS investigation of the metabolic response of the murine RIF-1 tumor to
  12. 5-fluorouracil chemother­apy. Texas A & M University NMR Newsletter, 377: 20-21.
  13. PE Sijens  (1989) 31P NMR spectroscopy of tumors in the evaluation of response to therapy. Eurospin Quarterly 20: 79-84.
  14. PE Sijens (1988) 31P NMR spectroscopy in the evaluation of response to therapy. PhD Thesis, niversity of Utrecht,.
  15. PB Dunki Jacobs, PE Sijens, CJA van Echteld, MC Ruevekamp, PW de Graaf  (1988) The impact of dietary manipulation on tumor metabolism and response to methotrexate. An in vivo 31P magnetic resonance study. In: Nutritional manipulation of the cancer bearing host; impact on host and tumor, with emphasis on the effect of chemotherapy. PhD Thesis, University of Amsterdam pp 89-97.
  16. PE Sijens (1986) An approach for dealing with quantitative changes in the in vivo 31P MR spectra of tissues, for instance tumors before and after therapy. Eurospin Quarterly 9: 108-109,.
  17. CJG Bakker, PE Sijens (1986) Some aspects of data analysis in quantitative NMR imaging. Eurospin Quarterly 7: 39.
  18. PE Sijens (1985) 31P NMR spectroscopieaantumoren. Cursusboek "Magneticresonance in levende systemen",Commissie voor PAOG Utrecht,Geldrop, 8-9 November, pp s1-s3.
  19. PE Sijens (1985) Tumor characterization by in vivo 31P NMR spectroscopy. A short review. EurospinQuarterly 5: 77-83.
  20. PE Sijens (1984) Fosfor NMR spectroscopie: een nieuw middel om tumoren te karakteriseren. Tijdschr Kanker 17-19, August.
  21. PE Sijens (1984) NMR onderzoek krijgt steeds grotere aantrek­kingskracht. Technovisie 39-48.

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