mu-chen
Mu Chen, PhD
Adjunct Associate Professor of Medical Physics

Duke Kunshan University
Suzhou Shi, Jiangsu Sheng, China
E-mail: mu.chen@duke.edu

Education

Institution and Location Year
Duke University, Biomedical Engineering Department, Durham, NC, USA 1998/7-2003/5
Tsinghua University, Engineering Physics Department, Beijing, China 1992/9-1997/7

Biography

In 1997 he obtained undergraduate degree from the Department of Engineering Physics in Tsinghua University, Beijing China. Then in 2003 he obtained Ph.D. degree from the department of Biomedical Engineering in Duke University, Durham, NC, USA. He joined Siemens Molecular Imaging in 2002 and worked as physicists, and later Senior Research Manager, and worked on PET/CT and later small animal PET/SPECT/CT systems. In 2011 he joined Shanghai United Imaging Healthcare as R&D VP for the molecular imaging business unit, and worked to develop a whole body high resolution PET/CT. In 2014 he was appointed as Adjunct Associate Professor in the graduate program of Medical Physics in Duke Kunshan University in Jiangsu, China.


Research Interest

  • Molecular imaging algorithms and systems, image quality evaluation, computer aided diagnostic, deep learning algorithms, interventional radiology procedures and equipment.


Scientific Activities

2016/10 - present InnoVision Imaging Laboratory, Research Triangle Park, NC Chief Scientist, Interventional imaging modalities research
2014/8 - present Duke Kunshan University, Kunshan, Jiangsu, ChinaAdjunct Associate Professor Teach seminars in the Medical Physics Graduate Program.
2011/4 - 2016/6 Shanghai United Imaging Healthcare Co. Ltd., Shanghai, China VP   of R&D, Corporate Research Center/Molecular Imaging Business Unit, As the head of R&D, lead the development of a whole body clinical PET/CT system consists of 16 slice CT and 96 ring PET, As technical expert, participated in discussion of various Chinese national or industrial nuclear medical equipment standards.
2002/8 - 2011/4 Siemens Medical Solutions, Molecular Imaging, Knoxville, Tennessee, USA Senior
2007 - 2011 Manager of Physics and Reconstruction, Pre-Clinical Systems,Lead smallanimal PET/SPECT/CT image corrections and reconstruction.
2006 - 2007 Staff Scientist, Clinical PET Systems, Biograph PET/CT image corrections and reconstruction
2002 - 2006 Senior Physicist, Clinical PET Systems, PET/SPECT image corrections and reconstruction. HRRT (high resolution research tomograph) image corrections and reconstruction
1998/8 –2002/8 Duke University Medical Center, Durham, NC, USA Research Assistant, Radiology, Biomedical Engineering. SPECT image corrections and reconstruction. SPECT myocardium perfusion imaging protocol evaluation
1997/8 –1998/7 North Carolina State University, Raleigh, NC, USA Research Assistant, Nuclear Engineering. Monte Carlo Simulation variance reduction methods, Statistical Model to analysis environmental pathway for radioactive material
Awards
2002/10 IEEE NPSS Phelps Award
2002/10 IEEE NPSS Graduate Scholarship Award
2001/10 IEEE Medical Imaging Conference Travel Award
1999 – 2000 The Whitaker Foundation Graduate Fellowship,          Duke University
1997 Alpha Nu Sigma Chapter, North Carolina State University

Publications

  1. Xiao Jin, Tim Mulnix Christine M.San Diego, Mu Chen, Richard E. Carson (2011) List-mode reconstruction for the FOCUS-220 with motion correction: Application to awake nonhuman primate imaging, Society of Nuclear Medicine Annual Meeting.
  2. M.Chen, S. Siegel, D. Hu (2010) Continuous Deadtime Estimation for PET, IEEE Nuclear Science Symposium Conference Record.
  3. M. Chen, V. Y. Panin, H. Rothfuss, S. Cho, I. Hong, R. M. Leahy (2010) System Matrix Calibration with Point Source Measurements for Preclinical PET, IEEE Nuclear Science Symposium Conference Record.
  4. F. J. Siepel, M van Lier, M Chen, J A. Disselhorst, A Meeuwis, W Oyen, O.Boerman and E P. Visser (2010) Scanning multiple mice in a small-animal PET scanner: Influence on image quality, Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment.
  5. Feng, B.; Chen, M.; Bai, B.; Smith, A.M.; Austin, D.W.; Mintzer, R.A.; Osborne, D.; Gregor, J. (2010) Modeling of the Point Spread Function by Numerical Calculations in Single-Pinhole and Multipinhole SPECT Reconstruction, Nuclear Science, IEEE Transactions on Volume: 57, Issue: 1, Part: 1, Page(s): 173 – 180,
  6. D. Austin, D. Osborne, M. Chen, J. Deng, S. Yan (2009)Feasibility and Performance of Simultaneous SPECT-CT Imaging, 2009 World Molecular Imaging  ongress, September 23-26, Montréal, Canada.
  7. M. Chen, M. E. Casey (2009) Per Ring Deadtime Correction for Preclinical, IEEE Nuclear Science Symposium Conference Record.
  8. Q. Bao, D. Newport, M. Chen, D.Stout, A. F. Chatziioannou (2009) Performance Evaluation of the Inveon Dedicated PET Preclinical Tomograph Based on the NEMA NU-4 Standard, Journal of Nuclear Medicine Vol. 50 No. 3 401-408.
  9. M. Chen, D. Osborne, S. Gleason (2008) Automated CT-based Attenuation Correction for Preclinical Multimodality PET/CT, IEEE Nuclear Science Symposium Conference Record.
  10. Wenli Wang, Mu Chen, Sean Carlin, Christoph Oehler, Pat Zanzonico and John Humm  (2008) Importance of Attenuation and Scatter Correction in Estimating Tumor Hypoxia via FMISO Dynamic Animal-PET Imaging, IEEE Nuclear Science Symposium Conference Record.
  11. Qinan Bao, Sanghee Cho, Quanzheng Li, Danny Newport, Mu Chen, Richard Leahy, Arion F. Chatziioannou (2008) Monte Carlo Based Estimation of Detector Response in a Large Solid Angle Preclinical PET Imaging System, IEEE Nuclear Science Symposium Conference Record.
  12. M. Chen, V. P. Panin, M. E. Casey (2006) Randoms Mean Value Estimation with Exact Method for Ring PET Scanner, IEEE Nuclear Science Symposium Conference Record.
  13. Maurizio Conti, Bernard Bendriem, Mike Casey, Mu Chen, Frank Kehren, Christian Michel and Vladimir Panin, First experimental results of time-of-flight reconstruction on an LSO PET scanner, Physics in Medicine and Biology50 4507-4526.
  14. M. Chen, C. Michel, M. Sibomana, V. Y. Panin, J-S. Liow, Z. Burbar, M. E. Casey (2005) Strategy to estimate statistical normalization parameters of 3D panel PET detector with DOI Conference Proceedings, Proceedings of the International Meeting on Fully 3D Reconstruction in Radiology and Nuclear Medicine.
  15. Mu Chen, Maurizio Conti, James Hamill, Steve Miller (2003) Count rate dependent axial normalization of panel detector, Society of Nuclear Medicine Annual Meeting.
  16. Rappoport, M. Chen, B. Bendriem, R. Nutt, S. Miller (2003) Low Energy SPECT using LSO Panel Detectors, Society of Nuclear Medicine Annual Meeting.
  17. M. Chen, JE. Bowsher, AH. Baydush, KL. Gilland, RJ. Jaszczak (2002) Using the Channelized Hotelling Observer on Multi-slice and Multi-view Simulated SPECT Myocardial Perfusion Images, IEEE Transactions on Nuclear Science, Volume 49,  Issue 3,  Part 1,  June  Page(s):661 – 667.
  18. M. Chen, J. Peter, RJ. Jaszczak, DR. Gilland, JE. Bowsher, MP. Tornai, SD. Metzler (2002) Observer Studies of Cardiac Lesion Detectability with Triple-Head 360 Degree versus Dual-Head 180 Degree SPECT Acquisition Using Simulated Projection Data, IEEE Transactions on Nuclear Science, Volume 49,  Issue 3,  Part 1,  June Page(s):655 – 660.
  19. M. Chen, RJ. Jaszczak, JE. Bowsher, DR. Gilland, CE. Metz (2002) Receiver Operating Characteristic Evaluation of Triple-Head 360 Degree versus Dual-Head 180 Degree Myocardial SPECT Acquisition, Society of Nuclear Medicine Annual Meeting.
  20. M. Chen, RJ. Jaszczak, JE. Bowsher, DR. Gilland (2001) An Evaluation of Cardiac Uniformity and Contrast with Dual-Head 180 degree and Triple-Head 360 degree SPECT Scans, IEEE Transactions on Nuclear Science, p1428-1434, Vol.48:No.4.
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