Education

Biography

Dr. Katherine (Kate) Klein, is a Clinical Associate Professor of Radiology and the Associate Director of Radiology Medical Student Education in the Department of Radiology at Michigan Medicine – The University of Michigan and a Core Member of the University of Michigan Comprehensive Cancer Center.  A graduate of the University of Windsor and Schulich School of Medicine, in London, Ontario. She completed her residency training at the Mayo Clinic in Rochester, MN, becoming board certified in Diagnostic Radiology in 1998.  She completed her Body Imaging (Cross-Sectional, MRI, Ultrasound) Fellowship at William Beaumont Hospital in Royal Oak, MI and her Breast Imaging Fellowship at the University of Michigan in Ann Arbor.  She is a Fellow in the American College of Radiology.

Dr. Klein has a broad background in medical education in the field of Radiology, with specific training and expertise in breast imaging, interventional radiology, and tomosynethsis.  Her expertise in medical student education is recognized at an institutional level as Lead Faculty for the Diagnostic and Therapeutic Branches Element and Doctoring Curriculum Development, at the University of Michigan Medical School Education Office. At a national level, she is Chair of the AUR (Association of University Radiologists) ACER (Alliance of Clinician-Educators in Radiology) Education Committee and the AUR AMSER (Alliance of Medical Student Educators in Radiology) Electronic Committee.

Research Interest

• Dr. Katherine (Kate) Klein, research is in the areas of resident and medical student teaching, simulation in radiology, tomosythesis, and many other areas of breast imaging.

Scientific Activities

Honors and Awards

Publications

1. Thomas D. Klein K, Mamvathue E, Dimmock JR, Mutus B.  Glutathione Levels During Thermal Induction of Yeast-to-Mycelial Transition in Candida.  FEMSMicrobiol Lett 1991; 61(2-3):331-334.PM: 2037237
2. Fraher LJ, Klein KA,  Marier R, Freeman D, Hodsman AB, Hendy N. Comparison of the Pharmacokinetics of Parental 1-34 PTH and 1-34-PTHrp in Healthy Humans. Journal of Bone and Mineral Research 1993; l8:S272.
3. Klein KA, Hobbs. Radiopacity of Glass:  does the lead content matter?  CMAJ 1995; Nov 1;  153(9):1224.PM: 1487487  PMCID 1487487
4. Fraher LJ, Klein KA, Marier R, Freeman D, Hendy GN, Goltzman D, Hodsman AB.  Comparison of the parenteral parathyroid hormone-(1-34) [PTH-(1-34)] and PTH-related peptide-(1-34) in healthy young humans.  J Clin EndocrinolMetab 1995; 80(1):60-64.PM: 7829640
5. Klein KA, Stephens DH, Welch TJ.  CT Characteristics of Metastatic Disease to the Pancreas.  Radiographics 1998; Mar 18(2):369-378.PM: 9536484
6. Ghavamian R, Klein KA, Stephens DH, LeRoy AJ, Richardson RL, Burch PA, Zincke H. Metastatic Renal Cell Carcinoma to the Pancreas: Clinical and Radiological Features.  Mayo Clin Proc 2000; Jun 75(6):581-586.PM: 10852418
7. Chan HP, Goodsitt MM, Hadjiiski LM, Bailey JE, Klein KA, Darner KL, Paramagul CP.  Digital Stereomammography: Observer Performance Study of the Effects of Magnification and Zooming on Depth Perception.  Supplement to SPIE Medical Imaging 2002.
8. Chan, H-P, Goodsitt MM, Hadjiiski LM, Bailey JA, Klein KA, Darner LD, Sahiner B.  Effects of Magnification and zooming on depth perception in digital stereomammography:  an observer performance study. Phys Med Biol 2003; 48:3721-3734.PM: 14680269
9. Hadjiiski LM, Chan HP, Sahiner B, Helvie MA, Roubidoux MA, Blane C, Paramagul C, Petrick N, Bailey J, Klein K, Foster M, Patterson S, Adler DD, Nees A, Shen, J. ROC study: effects of computer-aided diagnosis on radiologists’ characterization of malignant and benign breast masses in temporal pairs of mammograms.  Proc SPIE Medical Imaging 2003; 5032:94-101.
10. Helvie MA, Hadjiiski L, Makariou E, Chan HP, Petrick N, Sahiner B, Lo SCB, Freedman M, Adler D, Bailey J, Blane C, Hoff D, Hunt K, Joynt L, Klein K, Paramagul C, Patterson SK, Roubidoux MA.  Sensitivity of noncommercial computer-aided detection system for mammographic breast cancer detection: A Pilot Clinical Trial.  Radiology 2004; 231(1):208-214.PM: 14990808  PMCID 2742201
11. Roubidoux MA, Sabel MS, Bailey JE, Kleer CG, Klein KA, Helvie MA.  Small (<2.0-cm) Breast Cancers: Mammographic and US Findings at US-guided Cryoablation – Initial Experience.  Radiology 2004; 233(3):857-867.  PM: 15567802
12. Hadjiiski L, Chan HP, Sahiner B, Helvie MA, Roubidoux MA, Blane C, Paramagul C, Petrick N, Bailey J, Klein K, Foster M, Patterson S, Adler D, Nees A, Shen J. Improvement in radiologists’ characterization of malignant and benign breast masses on serial mammograms with computer-aided diagnosis: an ROC study.  Radiology 2004; 233(1):225-265.PM: 15317954
13. Jamadar DA, Carlos R, Caoli EM, Pernicano PG, Jacobson JA, Patel S, Noroozian M, Dong Q, Bailey JE, Patterson SK, Klein KA, Good JD, Kazerooni EA, Dunnick NR.  Estimating the effects of informal radiology resident teaching on radiologist productivity: What is the cost of teaching?  AcadRadiol 2005; 12(1): 123-128.PM: 15691733
14. Hadjiiski L, Sahiner B, Helvie MA, Chan HP, Roubidoux MA, Paramagul C, Blane C, Petrick N, Bailey J, Klein K, Foster M, Patterson SK, Adler D, Nees AV, Shen J.  Breast masses: Computer-aided diagnosis with serial mammograms.  Radiology 2006; 240(2):343-356.PM: 16801362
15. Martin KE*, Helvie MA, Zhou C, Roubidoux MA, Bailey JE, Paramagul C, Blane CE, Klein KA, Sonnad SS, Chan HP.  Mammographic density measured with quantitative computer-aided method: Comparison with radiologists’ estimates and BI-RADS categories.  Radiology 2006; 240(3):656-665.  PM: 16857974
16. Daly CP*, Bailey JE, Klein KA, Helvie MA.  Complicated breast cysts on sonography:  Is aspiration necessary to exclude malignancy?  AcadRadiol2008; 15(5):610-617.  PM: 18423318
17. Sahiner B, Chan HP, Hadjiiski LM, Roubidoux MA, Paramagul C, Bailey JE, Nees AV, Blane CE, Adler DD, Patterson SK, Klein KA, Pinsky RW, Helvie MA.  Multi-modality CADx: ROC study of the effect on radiologists’ accuracy in characterizing breast masses on mammograms and 3D ultrasound images.  AcadRadiol 2009; 16(7):810-818.  PM: 19375953  PMC2722036
18. Davenport MS*, Ellis JH, Shoukofeh H, Khalatbari MS, Myles JD, Klein KA.  Effect of work hours, caseload, shift type, and experience on resident call performance.  AcadRadiol 2010; 17(7):921-927.  PM: 20540912
19. Ruma J*, Klein KA, Chong S, Wesolowski J, Kazerooni EA, Ellis JH, Myles JD.  Cross-sectional examination interpretation discrepancies between On-Call diagnostic radiology residents and subspecialty faculty radiologists: Analysis by imaging modality and subspecialty.  J Am CollRadiol 2011; 8(6):409-414.  PM: 21636055
20. Noroozian M, Hadjiiski L, Rahnama-Moghadam S, Klein KA, Jeffries DO, Pinsky PR, Chan HP, Carlson PL, Helvie MA, Roubidoux MA.  Digital breast tomosynthesis is comparable to mammographic spot views for mass characterization.  Radiology2012; 262(1):61-68.  [Listed as ‘Top 10 Most Read Recent Articles’ in Radiology for Dec 2011-Feb 2012]PM: 21998048  PMC3244671
21. Hryhorczuk AL*, Stephens T*, Bude RO, Rubin JM, Bailey JE, Higgins EJ, Fox GA, Klein KA.  Prevalence of Malignancy in Thyroid Nodules with an Initial Nondiagnostic Result after Ultrasound Guided Fine Needle Aspiration.  Ultrasound Med Biol 2012; 38(4):561-567.PM: 22341051
22. Chapman M*, Washburn Z*, Neal C, Noroozian M, Roubidoux M, Klein K.  Breast MRI: Basic Evaluation and Beyond.  MedEdPORTAL, 2012; www.mededportal.org/publication/9181.
23. Padilla F, Roubidoux MA, Paramagul C, Sinha SP, Goodsitt MM, LeCarpentier GL, Chan HP, Hadjiiski LM, Fowlkes BJ, Joe AD, Klein KA, Nees AV, Noroozian M, Patterson SK, Pinsky RW, Hooi FM, Carson PL.  Breast mass characterization using 3-Dimensionalautomated ultrasound as an adjunct to digital breast tomosynthesis: A pilot study.  J Ultrasound Med 2013; 32(1):93-104.PM: 23269714  PMC3556642
24. Leschied JR*, Knoepp US, Hoff CN, Mazza MB, Klein KA, Mullan PB, Kelly AM.  Emergency Radiology Elective Improves Second-Year Medical Students’ Perceived Confidence and Knowledge of Appropriate Imaging Utilization.  AcadRadiol 2013; 20(9):1168-1176.PM:  23931432
25. Neal CH, Yilmaz ZN*, Noroozian M, Klein KA, Sundaram B, Kazerooni EA, Stojanovska J.  Imaging of breast cancer-related changes after surgical therapy.  AJR Am J Roentgenol2014;202(2):262-272.  PM:  24450664
26. Yilmaz ZN*, Neal CH, Noroozian M, Klein KA, Sundaram B, Kazerooni EA, Stojanovska J.  Imaging of Breast Cancer–Related Changes After Nonsurgical Therapy. AJR Am J Roentgenol 2014; 202(3):675-683.  PM:  24555607
27. Patterson SK, Neal CH, Jeffries DO, Joe A, Klein K, Bailey J, Pinsky R, Paramagul, C, Watcharotone K.  Outcomes of solid palpable masses assessed as BI-RADS 3 or 4A: a retrospective review.  Breast Cancer Res Treat 2014; 147(2):311-316.  PM: 25151294
28. Jacobson JA, Klein KA, Yablon CM.  Retrospective Research in Radiology from Concept to Publication: A Stepwise Guide for Trainees and Mentors.  AJR Am J Roentgenol 2014; 203(3):W301-W306.  PM:  25148188
29. Bosma MS*, Morden KL*, Klein KA, Neal CH, Knoepp US, Patterson SK.  Breast imaging after dark: Patient outcomes following evaluation for breast abscess in the emergency department after hours.  EmergRadiolFeb 2016; 23(1):29-33.  PM:  26433916
30. Bosma MS*, Neal CH, Klein KA, Noroozian M, Patterson SK, Helvie MA.  Does Direct Radiologist-Patient Verbal Communication Affect Follow-Up Compliance of Probably Benign Assessments?  J Am CollRadiolMar 2016; 13(3): 279–285.PM: 26777739
31. Klein KA, Neal CH.  Simulation in Radiology Education: Thinking Outside the Phantom. AcadRadiolJul 2016; 23(7):908-910.PM: 27052525
32. Morgan H, Zeller J, Hughes D, Dooley-Hash S, Klein KA, Santen S.  Applied Clinical Anatomy: The Successful Integration of Anatomy into Specialty Specific Senior Electives.  SurgRadiolAnatJan 2017; 39(1):95-101.  PM: 27307253
33. Stamm BS*, Smith E, Klein K.  Chest Radiograph Primer The Utility of Dedicated Radiology Small Group Learning to the Medical School Curriculum.  Michigan Journal of MedicineMay 2017; 2(1) http://dx.doi.org/10.3998/mjm.13761231.0002.110
34. Chan HP, Helvie MA, Hadjiiski L, Jeffries DO, Klein KA, Neal CH, Noroozian M, Paramagul C, Roubidoux MA.  Characterization of breast lesions in digital breast tomosynthesis and digital mammograms: An observer performance study.  AcadRadiol 2017; 24(11):1372-1379.  PM: 28647388  PMC5651188Acad Radiol2017; Epub ahead of print.PM: 28647388

Non-Peer Reviewed Publications

1. Testimonial for AMWA Centennial Book.  American Medical Women’s Association (AMWA) 100th Anniversary.  Eds. Nevarez N, McLaughlin S, Klein K.  February, 2015.

Scientific Presentations and Abstracts

1. Klein KA, Stephens DH, Welch TE.  CT Characteristics of Metastatic Disease to the Pancreas.  Abstract.  Society of Gastrointestinal Radiology.  Bermuda.March, 1996.
2. Klein KA, Stephens DH, Welch TE.  CT Characteristics of Metastatic Disease to the Pancreas.  Scientific Exhibit.  American Roentgen Ray Society San Diego, CA. May, 1996.
3. Klein KA, Stephens DH, Leroy AJ.  Renal Cell Carcinoma Metastases to the Pancreas.  Abstract.  Society of Genitourinary Radiology.  Santa Fe, NM.  May 1997.
4. Klein KA,Bis K, Jafri Z.  Contrast Enhanced 3D-MRA of Renal Transplants: A Pictorial Essay.  Scientific Exhibit.  Society of Gastrointestinal Radiology.  West Palm Beach, FL. March, 1999.
5. Jafri Z, Klein KA.  Interesting Unknown Cases.  Workshops.  Society of Gastrointestinal Radiology. Co-moderated and presented an interactive workshop to discuss the approach to difficult “unknown” cases to audience.  West Palm Beach, FL.March, 1999.
6. Klein KA, Bis K, Jafri Z.  Contrast Enhanced 3D-MRA of Renal Transplants. Abstract.  American Roentgen Ray Society.  New Orleans, LA. May, 1999.
7. Diponio EC (Medical Student), Roubidoux MA, Klein KA*, Pass H, Helvie MA.  Relationship of Mammographic Density to Surgical Outcome and Histological Findings in Patients with DCIS.  Abstract.  Association of University Radiologists.   Orlando FL.  April 6, 2000.
8. Klein KA, Helvie MA, Schott A, Hunt K, Pierce L.  Accuracy of Mammography in the Prediction of Residual Disease after the Neoadjuvant Chemotherapy for Stage I/II Breast Carcinoma.  Abstract.  American Roentgen Ray Society.  Washington, DC.  May, 2000.
9. Wang EY*, Hoff DL, Kronick S, Bailey JE, Klein KA, Caoili EM.  Radiology Resident On-call Coverage of Emergency Department Ultrasound: Rate of Discrepancies Compared to Subspecialty Radiologist Interpretation and Effect on Clinical Outcome.  Presented at the Annual Meeting of the Association of University Radiologists. Phoenix, AZ.  April 18, 2002.  (Received award/stipend for best Resident abstract presented at this conference).
10. Klein KA, Roubidoux MA. Computer Exhibit: Web-based Instructional Lecture for M1 Anatomy Course: “Introduction to Radiology”.  Association of University Radiologists Phoenix, AZ.  April, 2002.
11. Roubidoux MA, Chapman C, Gruppen L, Klein KA, Helvie MA.  Interactive Game for Breast Imaging Instruction.  Annual Meeting of the American Roentgen Ray Society.  Atlanta, GA. April 28-May 3, 2002.  Awarded Bronze Medal.
12. Hunt K*, Paramagul C, Roubidoux MA, Helvie MA, Bailey J, Hoff D, Joynt L, Klein K, Patterson S, Adler D.  The Utility of Breast Ultrasound in Distinguishing Benign and Malignant Solid Breast Masses.  Annual Meeting American Roentgen Ray Society. Atlanta, GA.  April 28 – May 3, 2002.
13. Hoff DL, Wang EY, Klein KA, Caoili EM, Patterson SK, Bailey JE, Eldevik OP, Gomez-Hassan DM, Sundgren PC, Patel S.  Radiology Resident On-call Interpretations of Cross-sectional Examinations from the Emergency Department: Rate and Grade of Discrepancies Compared to Subspecialty Radiologist Interpretations. Presented at the Annual Meeting of the American Roentgen Ray Society.  Atlanta, GA.  May 1, 2002.
14. Chan HP, Goodsitt MM, Hadjiiski LM, Helvie MA, Bailey J, Klein K, Roubidoux MA.  2002b Development of Digital Stereo Imaging Technique for Mammography.  Era of Hope Meeting (U.S. Army Medical Research and Material Command, Department of Defense, Breast Cancer Research Program, Orlando, FL.September 25-28, 2002).
15. Chan HP, Mitchell M, Helvie MA, Hadjiiski LM, Bailey J, Klein KA, Roubidoux M.  Development of Digital Stereo Imaging Technique for Mammography.  Abstract.  EOH 2002.
16. Goodsitt M, Chan HP, Gandra C, Chen N, Helvie M, Klein KA, Bailey J, Paramagul C.  Automated Spot Mammography:  A Comparison of Spot Imaging Regions Selected by Radiologists.  Abstract.  Medical Physics 2002; 29 (6):1307.
17. Kamaya A*, Klein KA, Helvie MA, Roubidoux, Paramagul C, Thorson N, Schott A.  Mammographic Evaluation of Early Stage Breast Carcinoma Before and After Neoadjuvant Chemotherapy.  Abstract American Roentgen Ray Society.  San Diego, CA.  May, 2003.
18. Rochester-Guest AB*, Riba M, Roubidoux MA, Bailey J, Klein K, Weaver J.  An Educational Module for Radiology Residents on “Breaking Bad News.”  Presented at the Annual Meeting of the Association of University Radiologists.  Miami, FL.  May, 2003.
19. Roubidoux MA, Helvie MA, Paramagul C, Klein KA, Thorson NJ, Schott AF, Hunt KA.  Neoadjuvant Chemotherapy: Comparison of Imaging Methods Using Mammography, MR Imaging, and 3D Ultrasound.  Presented at the 103rd Annual Meeting of the American Roentgen Ray Society.  San Diego, CA.  May 4-9, 2003.
20. Paramagul C, Helvie MA, Roubidoux MA, Klein K.  Screening Mammography Differences between Off-Line (Next Day) and On-Line (Same Day) Reading. Presented at the Annual Meeting of the American Roentgen Ray Society.  San Diego, CA.May 8, 2003.
21. Roubidoux MA, Packer SA, Klein KA* Paramagul C, Helvie MA.  3D Ultrasound of Breast Tumors in Patients Who Undergo Neoadjuvant Chemotherapy.  Presented at the Annual Meeting of the American Institute of Ultrasound in Medicine.  Montreal, Quebec, Canada.  June 3, 2003.
22. Roubidoux M, Sabel MS, Klein KA, Bailey JE, Helvie MA.  Ultrasound-guided Cryoablation of Breast Malignancies. Radiology Society of North America.  Chicago, IL.  November, 2003.
23. Klein KA, Kamaya A*, Helvie MA, Roubidoux MA, Paramagul C, Thorson N, Schott A. Mammographic Evaluation of Early Stage Breast Carcinoma Before and After Neoadjuvant Chemotherapy. American Roentgen Ray Society 103rd Annual Meeting, San Diego, CA.  May 4-9, 2003.
24. Roubidoux MA, Packer SA*, Klein KA, Paramagul C, Helvie MA.  3D Ultrasound of Breast Tumors in Patients Who Undergo Neoadjuvant Chemotherapy. American Institute of Ultrasound in Medicine, Montreal, Quebec, Canada.  June 3, 2003.
25. Pernicano P, Jamadar D, Carlos R, Jacobson J, Caoili E, Bailey J, Patterson S, Klein K, Patel S, Noroozian M*, Dong Q, Good J, Kazerooni E.  Quandary in Radiology Resident Education:  Is There a Relationship Between Informal Teaching Quality and Exam Interpretation Productivity?  In:  Medical Education Day 2004(P):44.  University of Michigan Medical School, Ann Arbor, MI.
26. Hryhorczuk AL*, Roubidoux MA, LeCarpentier G, Klein KA, Paramagul C, Carson PL.  Comparison of Breast Mass Characterization and Overall Image Quality Using Handheld versus Semiautomatic Ultrasound.  Association of University Radiologists 53rd Annual Meeting, Montreal, Quebec, Canada.  May 4-7, 2005, #02-10.
27. Daly CP*, Bailey JE, Klein KA, Helvie MA.  Sonography of Complicated Breast Cysts:  Is Aspiration Necessary to Exclude Malignancy?  Presented at the American Roentgen Ray Society.  Vancouver, British Columbia, Canada.May 5, 2006.
28. Robbins J*, Klein K, Roubidoux MA. Gastrointestinal Imaging: A Dynamic Teaching Modality.  Association of University Radiologists 54th Annual Meeting, Austin, TX. April 5-8, 2006. (E-118).
29. Robbins J, Klein K, Roubidoux MA, Gastrointestinal Imaging: A Dynamic Teaching Modality. Electronic exhibit selected to be posted on the Association of Program Directors in Radiology Website.  May 8, 2006.
30. Klein K, Robbins J*, Roubidoux MA, Breast Imaging: A Dynamic Teaching Modality.  Association of University Radiologists 54th Annual Meeting, Austin, TX.  April 5-8, 2006. (E-130).
31. Klein KA, Robbins J*, Roubidoux M.  Utilizing PowerPoint Gaming Techniques in Resident Conferences.  Presentation.  Enriching Scholarship 2006 University of Michigan, Ann Arbor, MI.  May 11, 2006.
32. Roubidoux MA, Haugen S, Bailey J, Klein K, Nees A, Paramagul C, Joe, A, Blane C. On-line screening mammography by satellite transmission for rural American Indian women.  American College of Radiology: Translating Quality into Economic Viability. Sun Valley, ID. August 24, 2006.
33. Stephens T*, Klein KA, Higgins E, Fox G, Rubin J, Bude R, Bailey JA.  Prevalence of Malignancy in Thyroid Nodules with an Initial Non-Diagnostic Result after Ultrasound Guided FNA with Specimens Placed in CytoLyt.  Association of University Radiologists, Seattle, WA.March 25, 2008.
34. Roubidoux MA, Jeffries D, Joe A, Klein KA, Patterson SK, Pinsky R, Hadjiyski L, Sinha S, Carson PL.  Interpretation times in dual modality imaging using automated breast ultrasound with digital tomosynthesis mammography: reader study.  ARRS, Boston, MA.  April 22, 2009.
35. LeCarpentier G, Roubidoux MA, Sinha SP, Chan HP, Goodsitt M, Carson PL, Pinsky R, Jeffries D, Joe A, Klein KA, Patterson SK.  Multimodality breast X-ray tomosynthesis and automated ultrasound imaging: a preliminary reader study.  Radiology Society of North America, Chicago, IL.  November 30, 2009.
36. Davenport MS*, Ellis JH, Shoukofeh H, Khalatbara MS, Myles JD, Klein KA.  Effect of work hours, caseload, shift type, and experience on resident call performance.  Association University Radiologists San Diego, CA.  March 2010.
37. Ruma J*, Klein KA, Chong S, Wesolowski J, Kazerooni E, Ellis JH, Myles J.  Subspecialty and Imaging Modality Analysis of Cross-Sectional Interpretation Discrepancies between On Call Radiology Residents and Subspecialty Faculty Radiologists at an Academic Quaternary Hospital.  American Roentgen Ray Society, San Diego, CA.  May 2010.
38. Hammer MR*, Klein KA, Karls E, Wells SA, Patel S*, Bailey JE, et. al.  Clinician Satisfaction with On-Call Radiology Resident Services.  Abstract #3430.  Association of University of Radiologists (AUR) 61st Annual Meeting.  Los Angeles, CA.  April 10-11, 2013.
39. Chapman MC*, Shah GV, Roubidoux MA, Klein KA.  A PowerPoint Alternative: Using Prezi to Teach Radiology to Medical Students.  Scientific Presentation.  62nd Annual Meeting of the Association of University Radiologists (AUR), Baltimore, MD.  April 3, 2014.
40. Bosma MS*, Neal CH, Klein KA, Noroozian M, Patterson SK, Helvie MA.  Does Direct Radiologist-Patient Verbal Communication Affect Follow-up Compliance of Probably Benign Assessments?  Invited Oral Presentation.  Society of Breast Imaging (SBI) Symposium, Orlando, FL.  April 25, 2015.