Ralph Nigel Martins
Ralph Nigel Martins, AO, PhD, FRSM, Cit WA, KSJ, MAICD
Professor and Director

Sir James Mc Cusker Alzheimer's Disease Research Unit
Edith Cowan University


B.Sc.(Hons.) (First Class) The candidate graduated from the University of Western Australia in 1981 with a major in Biochemistry and a minor in Chemistry
Ph.D A thesis entitled “The Regulation of the hexose monophosphate dehydrogenases in tissues of the female rat” was successfully completed for the degree of Doctor of Philosophy of the University of Western Australia in 1986.



Professor Ralph Martins’ research career in the field of Ageing and Alzheimer’s disease (AD) has spanned the past 30 years. Recognition of his tireless pursuit of research excellence but most importantly functional and clinical outcomes has come in the form of: over 260 (20A* ARC ERA ranked) peer-reviewed publications, published in prestigious high impact journals, such as the Journal of the American Medical Association, and cited over 10,371 times since 1996; numerous keynote presentation invitations; a stupendous testimony of securing research funding; community engagement; industry collaboration; and the generation of commercially and clinically valuable intellectual property, with 8 patents leading to successful commercialization outcomes.    He holds numerous Adjunct Professorial appointments with esteemed universities around the world. He was instrumental in establishing the McCusker Alzheimer’s Research Foundation in 2001 and is the Director of Research. Dr Malcolm McCusker AC CVO QC, the former Western Australian Governor is the patron of the Foundation. In 2003, Professor Martins was appointed to the position of Senior Editor, for the Journal of Alzheimer’s Disease and Editorial Board Member for Current Drug Targets CNS & Neurological Disease. In 2004, Professor Martins was appointed by Edith Cowan University to the Inaugural Chair in Ageing and Alzheimer’s.  He commenced a research program at Pelita Harapan in 2006 to study genetic risk factors for Ageing and AD in 4 ethnic communities. In 2006, he was appointed to an Adjunct Professorial position at Thomas Jefferson University’s Farber Neurosciences Institute and he was awarded a prestigious US National Institutes of Health (NIH) program grant. Through his outstanding leadership and dedication, Professor Martins has built a substantial and world-class research and clinical capacity in Western Australia with active links to international peers at the forefront of research.  In recognition of his outstanding research achievements, Professor Martins was awarded a number of very prestigious accolades, including the Melvin Jones Award from Lions Club International Foundation USA in 2010 (which is the highest Award that Lions can bestow recognising outstanding service to the community and being one of only two recipients of this award by the Club in the last 25 years), the Western Australian of the Year in 2010, the Western Australian Citizen of the Year in 2011, the Paul Harris Fellow by the Rotary Club in 2011, Member of the Order of the Knights of St John of Jerusalem (KSJ) in 2013 and the Officer of the Order of Australia (AO) in the General Division in 2013.


Research Interest

Ralph's current research interests are focused on understanding the mechanisms and factor(s) leading to the abnormal release and deposition of βA4 in Alzheimer's disease.

Professional Activities:

  • 1980-1997; 2000-2004: Australian Society for Biochemistry and Molecular Biology
  • 1982-1997: Australian Society for Medical Research
  • 1984-2002: Australian Neuroscience Society
  • 1984-1991: Australian Nutrition Foundation
  • 1991-2002: Surgical Research Society of Australasia
  • 1991-2004: Australian Association of Gerontology (WA)
  • 1992-2004: Alzheimer’s Association (WA)
  • 1996-2004: Society of Neuroscience (USA)
  • 2000-2004: The Australian Menopause Society
  • 2002-2004: Human Genetics Society of Australia
  • 2003-2004: European Society of Human Genetics Dementia & Neurodegenerative DISeases Group (DANDIS)



  1. Rembach, A., Stingo, FC., Peterson, C., Vannucci, M., Do, K., Wilson, WJ., Macaulay, SL., Ryan, TM., Martins, R., Ames, D., Masters, CL., Doecke, JD., Aibl Research Group, .., (2015), Bayesian graphical network analyses reveal complex biological interactions specific to Alzheimer's disease. Journal of Alzheimer's Disease, 44(3), 917-925, Amsterdam, Netherlands, DOI: 10.3233/JAD-141497.
  2. Chatterjee, P., Gupta, V., Fagan, A., Jasielec, M., Xiong, C., Sohrabi, H., Dhaliwal, S., Taddei, K., Bourgeat, P., Brown, B., Benzinger, T., Bateman, R., Morris, J., Martins, R., (2015), Decreased Platelet APP Isoform Ratios in Autosomal Dominant Alzheimer's Disease: Baseline Data from a DIAN Cohort Subset. Current Alzheimer Research, 12(2), 157-164, Bussum, Netherlands.
  3. Asih, P., Wahjoepramono, EJ., Aniwiyanti, V., Wijaya, L., De Ruyck, K., Taddei, K., Fuller, SJ., Sohrabi, H., Dhaliwal, SS., Verdile, G., Carruthers, M.,Martins, R., (2015), Testosterone Replacement Therapy in Older Male Subjective Memory Complainers: Double-Blind Randomized Crossover Placebo-Controlled Clinical Trial of Physiological Assessment and Safety. CNS and Neurological Disorders, 14(5), 576-586, Bussum, Netherlands.
  4. Gardener, S., Rainey-Smith, S., Martins, R., (2015), Diet and Inflammation in Alzheimer's Disease and Related Chronic Diseases: A Review. Journal of Alzheimer's disease, 50(2016), 301-334, Netherlands, DOI: 10.3233/JAD-150765.
  5. Gardener, S., Rainey-Smith, S., Macaulay, SL., Taddei, K., Rembach, A., Maruff, P., Ellis, K., Masters, C., Rowe, C., Ames, D., Keogh, J., Martins, R., Aibl Group, T., (2015), Comparative analysis of the Cancer Council of Victoria and the online Commonwealth Scientific and Industrial Research Organisation FFQ. British Journal of Nutrition, 114(10), 1683-1693, Cambridge, United Kingdom, DOI: 10.1017/S0007114515003335.
  6. Verdile, G., Keane, KN., Cruzat, VF., Medic, S., Sabale, M., Rowles, J., Wijesekara, N., Martins, R., Fraser, PE., Newsholme, P., (2015), Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer?s Disease. Mediators of Inflammation, 6(2015), Article No. 105828, New York, USA, DOI: 10.1155/2015/105828.
  7. Nik, SH., Newman, M., Wilson, L., Ebrahimie, E., Wells, S., Musgrave, I., Verdile, G., Martins, R., Lardelli, M., (2015), Alzheimer?s disease-related peptide PS2V plays ancient, conserved roles in suppression of the unfolded protein response under hypoxia and stimulation of ?-secretase activity. Human Molecular Genetics, 24(13), 3662-3678, United Kingdom, DOI: 10.1093/hmg/ddv110.
  8. Verdile, G., Asih, PR., Barron, AM., Wahjoepramono, EJ., Ittner, LM., Martins, R., (2015), The impact of luteinizing hormone and testosterone on beta amyloid (A?) accumulation: Animal and human clinical studies. Hormones and Behaviour, 76(November 01), 81-90, DOI: 0.1016/j.yhbeh.2015.05.020.
  9. Verdile, G., Fuller, SJ., Martins, R., (2015), The role of type 2 diabetes in neurodegeneration. Neurobiology of Disease, 84(2015), 22-38, Maryland Heights, USA, DOI: 10.1016/j.nbd.2015.04.008.
  10. Buckley, RF., Ellis, KA., Ames, D., Rowe, CC., Lautenschlager, NT., Maruff, P., Villemagne, V., Macaulay, SL., Szoeke, C., Martins, R., Masters, CL., Savage, G., Rainey-Smith, S., Rembach, A., Saling, MM., Aibl Research Group, .., (2015), Phenomenological characterization of memory complaints in preclinical and prodromal Alzheimer's disease. Neuropsychology, 29(4), 571-581, Washington DC, United States, DOI: 10.1037/neu0000156.
  11. Ying Lim, Y., Pietrzak, RH., Bourgeat, P., Ames, D., Ellis, KA., Rembach, A., Harrington, K., Salvado, O., Martins, R., Snyder, PJ., Masters, C., Rowe, CC., Villemagne, VL., Maruff, P., (2015), Relationships between performance on the cogstate brief battery, neurodegeneration, and a? accumulation in cognitively normal older adults and adults with MCI. Archives of Clinical Neuropsychology, 30(1), 49-58, Oxford, United Kingdom, DOI: 10.1093/arclin/acu068.
  12. Pietrzak, R., Lim, YY., Neumeister, A., Ames, D., Ellis, K., Harrington, K., Lautenschlager, N., Restrepo, C., Martins, R., Masters, C., Villemagne, V., Rowe, C., Maruff, P., (2015), Amyloid-?, Anxiety, and Cognitive Decline in Preclinical Alzheimer Disease A Multicenter, Prospective Cohort Study. JAMA Psychiatry, 72(3), 284-291, United States, DOI: 10.1001/jamapsychiatry.2014.2476.
  13. Li, Q., Villemagne, V., Doecke, J., Rembach, A., Sarros, S., Varghese, S., McGlade, A., Laughton, K., Pertile, K., Fowler, C., Rumble, R., Trounson, B., Taddei, K., Rainey-Smith, S., Laws, S., Robertson, J., Evered, L., Silbert, B., Ellis, K., Rowe, C., Macaulay, S., Darby, D., Martins, R., Ames, D., Masters, C., Collins, S., (2015), Alzheimer?s Disease Normative Cerebrospinal Fluid Biomarkers Validated in PET Amyloid-? Characterized Subjects from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. Journal of Alzheimer's Disease, 48(1), 175-187, Amsterdam, Netherlands, DOI: 10.3233/JAD-150247.
  14. Rembach, A., Evered, L., Li, Q., Nash, T., Vidaurre, L., Fowler, CJ., Pertile, KK., Rumble, RL., Trounson, BO., Maher, S., Mooney, F., Farrow, M., Taddei, K., Rainey-Smith, S., Laws, S., Macaulay, SL., Wilson, W., Darby, DG., Martins, R., Ames, D., Collins, S., Silbert, B., Masters, CL., Doecke, JD., Aibl Research Group, .., (2015), Alzheimer's Disease cerebrospinal fluid biomarkers are not influenced by gravity drip or aspiration extraction methodology. Alzheimer's Research and Therapy, 7(2015), Article number 71, London, United Kingdom, DOI: 10.1186/s13195-015-0157-7.
  15. Thai, C., Lim, YY., Villemagne, VL., Laws, S., Ames, D., Ellis, KA., Rainey-Smith, S., Martins, R., Masters, CL., Rowe, CC., Maruff, P., Aibl Research Group, .., (2015), Amyloid-Related Memory Decline in Preclinical Alzheimer?s Disease is Dependent on APOE ?4 and is Detectable over 18-Months. PLoS One, 10(10), Article number e0139082, San Francisco, California, United States, DOI: 10.1371/journal.pone.0139082.
  16. Wang, F., Gordon, BA., Ryman, DC., Ma, S., Xiong, C., Hassenstab, J., Goate, A., Fagan, AM., Cairns, NJ., Marcus, DS., McDade, E., Ringman, JM., Graff-Radford, NR., Ghetti, B., Farlow, MR., Sperling, R., Salloway, S., Schofield, PR., Masters, CL., Martins, R., Rossor, MN., Jucker, M., Danek, A., Forster, S., Lane, CA., Morris, JC., Benzinger, TL., Bateman, RJ., (2015), Cerebral amyloidosis associated with cognitive decline in autosomal dominant Alzheimer disease. Neurology, 85(9), 790-798, Philadelphia, Pennsylvania, United States, DOI: 10.?1212/?WNL.?0000000000001903.
  17. Hollands, S., Lim, Y., Buckley, R., Pietrzak, R., Snyder, P., Ames, D., Ellis, K., Harrington, K., Lautenschlager, N., Martins, R., Masters, C., Villemagne, V., Rowe, C., Maruff, P., (2015), Amyloid-? Related Memory Decline is not Associated with Subjective or Informant Rated Cognitive Impairment in Healthy Adults. Journal of Alzheimer's Disease, 43(2), 677-686, Netherlands, DOI: 10.3233/JAD-140678.
  18. Fernando, B., Martins, I., Goozee, K., Brennan, C., Jayasena, V., Martins, R., (2015), The role of dietary coconut for the prevention and treatment of Alzheimer's disease: potential mechanisms of action. The British Journal of Nutrition, 114(1), 1-14, Cambridge, United Kingdom, DOI: 10.1017/S0007114515001452.
  19. Johnson, L., Sohrabi, H., Hall, J., Taddei, K., Edwards, M., O'Bryant, S., Martins, R., (2015), A depressive endophenotype of poorer cognition among cognitively healthy community-dwelling adults: results from the Western Australia memory study. International Journal of Geriatric Psychiatry, 30(8), 881-886, DOI: 10.1002/gps.4231.
  20. Gupta, V., Wilson, A., Burnham, S., Hone, E., Pedrini, S., Laws, S., Lim, F., Rembach, A., Rainey-Smith, S., Ames, D., Cobiac, L., Macaulay, SL., Masters, C., Rowe, C., Bush, A., Martins, R., (2015), Follow-up plasma apolipoprotein E levels in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL) cohort. Alzheimer's Research and Therapy, 7(1), Article no.16, United Kingdom, DOI: 10.1186/s13195-015-0105-6.
  21. Sohrabi, H., Bates, K., Weinborn, M., Bucks, R., Rainey-Smith, S., Rodrigues, M., Bird, S., Brown, B., Beilby, J., Howard, M., Criddle, A., Wraith, M., Taddei, K., Martins, G., Paton, A., Shah, T., Dhaliwal, S., Mehta, P., Foster, J., Martins, I., Lautenschlager, N., Mastaglia, F., Laws, S., Martins, R., (2015), Bone mineral density, adiposity, and cognitive functions. Frontiers in Aging Neuroscience, 7(FEB), Article no. 16, Lausanne, Switzerland, DOI: 10.3389/fnagi.2015.00016.
  22. Goozee, K., Shah, T., Sohrabi, H., Rainey-Smith, S., Brown, B., Verdile, G., Martins, R., (2015), Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer's disease. British Journal of Nutrition, 115(3), 449-465, Cambridge, United Kingdom, DOI: 10.1017/S0007114515004687.
  23. Fagan, A., Xiong, C., Jasielec, M., Mateusz, R., Goate, A., Benzinger, T., Ghetti, B., Martins, R., Masters, C., Mayeux, R., Ringman, J., Rossor, M., Salloway, S., Schofield, P., Sperling, R., Marcus, D., Cairns, N., Buckles, V., Ladenson, J., Morris, J., Holtzman, D., (2014), Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer's disease. Science Translational Medicine, 6(226), Article no. 226ra30, DOI: 10.1126/scitranslmed.3007901.
  24. Lim, F., Martins, I., Martins, R., (2014), The Involvement of Lipids in Alzheimer's Disease. Journal of Genetics and Genomics, 41(5), 261-274, DOI: 10.1016/j.jgg.2014.04.003.
  25. Yates, P., Desmond, P., Phal, P., Steward, C., Szoeke, C., Salvado, O., Ellis, K., Martins, R., Masters, C., Ames, D., Villemagne, V., Rowe, C., (2014), Incidence of cerebral microbleeds in preclinical Alzheimer disease. Neurology, 82(14), 1266-1273, DOI: 10.1212/WNL.0000000000000285.
  26. Bates, K., Vink, R., Martins, R., Harvey, A., (2014), Aging, cortical injury and Alzheimer's disease-like pathology in the guinea pig brain. Neurobiology of Aging, 35(6), 1345-1351, United States, DOI: 10.1016/j.neurobiolaging.2013.11.020.
  27. Moussavi Nik, SH., Newman, M., Ganesan, S., Chen, M., Martins, R., Verdile, G., Lardelli, M., (2014), Hypoxia alters expression of Zebrafish Microtubule-associated protein Tau (mapta, maptb) gene transcripts. BMC Research Notes, 7(2014), Article 767, London, United Kingdom, DOI: 10.1186/1756-0500-7-767.
  28. Rembach, A., Hare, D., Doecke, J., Burnham, S., Volitakis, I., Fowler, C., Cherny, R., McLean, C., Grimm, R., Martins, R., Ames, D., Masters, C., Bush, A., Roberts, B., (2014), Decreased serum zinc is an effect of ageing and not Alzheimer?s disease. Metallomics: integrated biometal science, 6(7), 1216-1219, DOI: 10.1039/c4mt00060a.
  29. Brown, B., Bourgeat, P., Peiffer, J., Burnham, S., Laws, S., Rainey-Smith, S., Bartres-Faz, D., Villemagne, V., Taddei, K., Rembach, A., Bush, A., Ellis, K., Macaulay, SL., Rowe, C., Ames, D., Masters, C., Maruff, P., Martins, R., (2014), Influence of BDNF Val66Met on the relationship between physical activity and brain volume. Neurology, 83(15), 1345-52, DOI: 10.1212/WNL.0000000000000867.
  30. Shah, T., Verdile, G., Sohrabi, H., Campbell, A., Putland, E., Cheetham, C., Dhaliwal, S., Weinborn, M., Maruff, P., Darby, D., Martins, R., (2014), A combination of physical activity and computerized brain training improves verbal memory and increases cerebral glucose metabolism in the elderly. Translational Psychiatry, 4(12), Article no. e487, United Kingdom, DOI: 10.1038/tp.2014.122.
  31. Gardener, S., Rainey-Smith, S., Barnes, M., Sohrabi, H., Weinborn, M., Lim, Y., Harrington, K., Taddei, K., Gu, Y., Rembach, A., Szoeke, C., Ellis, K., Masters, C., Macaulay, S., Rowe, C., Ames, D., Keogh, J., Scarmeas, N., Martins, R., For the Aibl, RG., (2014), Dietary patterns and cognitive decline in an Australian study of ageing. Molecular Psychiatry, online(online), online, United Kingdom.
  32. Martins, I., Gupta, V., Wilson, A., Fuller, SJ., Martins, R., (2014), Interactions Between Apo E and Amyloid Beta and their Relationship to Nutriproteomics and Neurodegeneration. Current Proteomics: the journal for current and in-depth reviews on proteomics, 11(3), 171-183, Netherlands.
  33. Francois, M., Leifert, W., Hecker, J., Faunt, G., Martins, R., Thomas, P., Fenech, M., (2014), Altered cytological parameters in buccal cells from individuals with mild cognitive impairment and Alzheimer's disease. Cytometry Part A, 85(8), 698-708, DOI: 10.1002/cyto.a.22453.
  34. Ryman, D., Acosta-Baena, N., Aisen, P., Bird, T., Danek, A., Fox, N., Goate, A., Frommelt, P., Ghetti, B., Langbaum, J., Lopera, F., Martins, R., Masters, C., Mayeux, R., McDade, E., Moreno, S., Reiman, E., Ringman, J., Salloway, S., Schofield, P., Sperling, R., Tariot, P., Xiong, C., Morris, J., Bateman, R., (2014), Symptom onset in autosomal dominant Alzheimer disease: a systematic review and meta-analysis. Neurology, 83(3), 253-260, United States, DOI: 10.1212/WNL.0000000000000596.
  35. Thomas, J., Brier, M., Bateman, R., Snyder, A., Benzinger, T., Xiong, C., Raichle, M., Holtzman, D., Sperling, R., Mayeux, R., Ghetti, B., Ringman, J., Salloway, S., McDade, E., Rossor, M., Ourselin, S., Schofield, P., Masters, C., Martins, R., Weiner, M., Thompson, P., Fox, N., Koeppe, R., Jack, C., Mathis, C., Oliver, A., Blazey, T., Moulder, K., Buckles, V., Hornbeck, R., Chhatwal, J., Schultz, A., Goate, A., Fagan, A., Cairns, N., Marcus, D., Morris, C., Ances, B., (2014), Functional connectivity in autosomal dominant and late-onset Alzheimer disease. JAMA: Journal of the American Medical Association, 71(9), 1111-1122, DOI: 10.1001/jamaneurol.2014.1654.
  36. Lim, YY., Villemagne, VL., Laws, S., Pietrzak, RH., Snyder, PJ., Ames, D., Ellis, KA., Harrington, K., Rembach, A., Martins, R., Rowe, CC., Masters, CL., Maruff, P., (2014), APOE and BDNF polymorphisms moderate amyloid ?-related cognitive decline in preclinical Alzheimer's disease. Molecular Psychiatry, online first(online first), 1-7, United Kingdom, DOI: 10.1038/mp.2014.123.
  37. Rembach, A., Watt, A., Wilson, W., Villemagne, V., Burnham, S., Ellis, K., Maruff, P., Ames, D., Rowe, C., Macaulay, S., Bush, A., Martins, R., Masters, C., Doecke, J., Aibl Research Group, T., (2014), Plasma amyloid-? levels are significantly associated with a transition towards Alzheimer?s disease as measured by cognitive decline and change in neocortical amyloid burden. Journal of Alzheimer's Disease, 40(1), 95-104, Netherlands, DOI: 10.3233/JAD-131802.
  38. Moore, E., Ames, D., Mander, A., Carne, R., Brodaty, H., Woodward, M., Boundy, K., Ellis, K., Bush, A., Faux, N., Martins, R., Masters, C., Rowe, C., Szoeke, C., Watters, D., (2014), Among vitamin B12 deficient older people, high folate levels are associated with worse cognitive function: combined data from 3 cohorts. Journal of Alzheimer's Disease, 39(2014), 661-668 , Netherlands, DOI: 10.3233/JAD-131265.
  39. Francois, M., Leifert, W., Martins, R., Thomas, P., Fenech, M., (2014), Biomarkers of Alzheimer's disease risk in peripheral tissues; focus on buccal cells. Current Alzheimer Research, 11(6), 519-531, DOI: 10.2174/1567205011666140618103827.
  40. Lim, YY., Villemagne, V., Laws, S., Ames, D., Pietrzak, R., Ellis, K., Harrington, K., Bourgeat, P., Bush, A., Martins, R., Masters, C., Rowe, C., Maruff, P., (2014), Effect of BDNF Val66Met on memory decline and hippocampal atrophy in prodromal Alzheimer?s disease: A preliminary study. PLoS One, 9(1), Article no. e86498, DOI: 10.1371/journal.pone.0086498.
  41. Buckley, R., Saling, M., Irish, M., Ames, D., Rowe, C., Lautenschlager, N., Maruff, P., Macaulay, SL., Martins, R., Masters, C., Rainey-Smith, S., Rembach, A., Savage, G., Szoeke, C., Ellis, K., (2014), Personal memory function in mild cognitive impairment and subjective memory complaints: Results from the Australian Imaging, Biomarkers, and Lifestyle (AIBL) study of ageing. Journal of Alzheimer's Disease, 40(3), 551-561 , Netherlands, DOI: 10.3233/JAD-131820.
  42. Bourgeat, P., Villemagne, V., Dore, V., Brown, B., Macaulay, SL., Martins, R., Masters, C., Ames, D., Ellis, K., Rowe, C., Salvado, O., Fripp, J., (2014), Comparison of MR-less PiB SUVR quantification methods. Neurobiology of Aging, 36(S1), S159-S166, United States, DOI: 10.1016/j.neurobiolaging.2014.04.033.
  43. Kanyenda, L., Verdile, G., Martins, R., Meloni, B., Chieng, J., Mastaglia, F., Laws, S., Anderton, R., Boulos, S., (2014), Is cholesterol and amyloid-? stress induced CD147 expression a protective response? Evidence that extracellular cyclophilin a mediated neuroprotection is reliant on CD147. Journal of Alzheimer's Disease, 39(3), 545-546, Netherlands, DOI: 10.3233/JAD-131442.
  44. Buckley, R., Saling, M., Irish, M., Ames, D., Rowe, C., Villemagne, V., Lautenschlager, N., Maruff, P., Macaulay, L., Martins, R., Szoeke, C., Masters, C., Rainey-Smith, S., Rembach, A., Savage, G., Ellis, K., Aibl Research Group, T., (2014), Autobiographical narratives relate to Alzheimer?s disease biomarkers in older adults. International Psychogeriatrics, 26(10), 1737-1746, DOI: 10.1017/S1041610214001136.
  45. Lim, YY., Maruff, P., Pietrzak, R., Ellis, K., Darby, D., Ames, D., Harrington, K., Martins, R., Masters, C., Szoeke, C., Savage, G., Villemagne, V., Rowe, C., (2014), A? and cognitive change: Examining the preclinical and prodromal stages of Alzheimer?s disease. Alzheimer's and Dementia, 10(16), 743-751, United States, DOI: 10.1016/j.jalz.2013.11.005.
  46. Pietrzak, R., Scott, J., Neumeister, A., Lim, YY., Ames, D., Ellis, K., Harrington, K., Lautenschlager, N., Szoeke, C., Martins, R., Masters, C., Villemagne, V., Rowe, C., Maruff, P., (2014), Anxiety symptoms, cerebral amyloid burden and memory decline in healthy older adults without dementia: 3-year prospective cohort study. British Journal of Psychiatry, 204(5), 400-401, DOI: 10.1192/bjp.bp.113.134239.
  47. Lim, YY., Maruff, P., Pietrzak, R., Ames, D., Ellis, K., Harrington, K., Lautenschlager, N., Szoeke, C., Martins, R., Masters, C., Villemagne, V., Rowe, C., (2014), Effect of amyloid on memory and non-memory decline from preclinical to clinical Alzheimer?s disease. Brain: a journal of neurology, 137(1), 221-231 , DOI: 10.1093/brain/awt286.
  48. Villemagne, V., Dore, V., Yates, P., Brown, B., Mulligan, R., Bourgeat, P., Veljanoski, R., Rainey-Smith, S., Ong, K., Rembach, A., Williams, R., Burnham, S., Laws, S., Salvado, O., Taddei, K., Macaulay, SL., Martins, R., Ames, D., Masters, C., Rowe, C., (2014), En Attendant Centiloid. Advances in Research, 2(12), 723-729, Online, DOI: 10.9734/AIR/2014/11599.
  49. Faux, N., Rembach, A., Wiley, J., Ellis, K., Ames, D., Fowler, C., Martins, R., Pertile, K., Rumble, R., Trounson, B., Masters, C., Aibl Research Group, T., Bush, A., (2014), An anemia of Alzheimer?s disease. Molecular Psychiatry, 19(11), 1227-1234, United Kingdom, DOI: 10.1038/mp.2013.178.
  50. Newman, M., Wilson, L., Verdile, G., Lim, A., Khan, I., Moussavi Nik, S., Pursglove, S., Chapman, G., Martins, R., Lardelli, M., (2014), Differential, dominant activation and inhibition of notch signalling and APP cleavage by truncations of PSEN1 in human disease deficits. Human Molecular Genetics, 23(3), 602-617, DOI: 10.1093/hmg/ddt448.
  51. Rembach, A., Watt, A., Wilson, W., Rainey-Smith, S., Ellis, K., Rowe, C., Villemagne, V., Macaulay, S., Bush, A., Martins, R., Ames, D., Masters, C., Doecke, J., Aibl Research Group, T., (2014), An increased neutrophil-lymphocyte ratio in Alzheimer?s disease is a function of age and is weakly correlated with neocortical amyloid accumulation. Journal of Neuroimmunology, 273(1-2), 65-71, DOI: 10.1016/j.jneuroim.2014.05.005.
  52. Laske, C., Sohrabi, H., Frost, S., Lopez-De-Ipina, K., Garrard, P., Buscema, M., Dauwels, J., Soekadar, S., Mueller, S., Linnemann, C., Bridenbaugh, S., Kanagasingam, Y., Martins, R., O?bryant, S., (2014), Innovative diagnostic tools for early detection of Alzheimer?s disease. Alzheimer's and Dementia, Article in press(Article in press), 1-18, United States, DOI: 10.1016/j.jalz.2014.06.004.
  53. Rembach, A., Faux, N., Watt, A., Pertile, K., Rumble, R., Trounson, B., Fowler, C., Roberts, B., Perez, K., Li, Q., Laws, S., Taddei, K., Rainey-Smith, S., Robertson, J., Vandijck, M., Vanderstichele, H., Barnham, K., Ellis, K., Szoeke, C., Macaulay, L., Rowe, C., Villemagne, V., Ames, D., Martins, R., Bush, A., Masters, C., Aibl Research Group, T., (2014), Changes in plasma amyloid beta in a longitudinal study of aging and Alzheimer's disease. Alzheimer's and Dementia, 10(1), 53-61, United States, DOI: 10.1016/j.jalz.2012.12.006.
  54. Asih, P., Chatterjee, P., Verdile, G., Gupta, V., Trengove, RD., Martins, R., (2014), Clearing the amyloid in Alzheimers: progress towards earlier diagnosis and effective treatments - an update for clinicians. Neurodegenerative Disease Management, 4(5), 363-378, London, United Kingdom, DOI: 10.2217/nmt.14.29.
  55. Cheng, L., Doecke, J., Sharples, RA., Villemagne, VL., Fowler, CJ., Rembach, A., Martins, R., Rowe, CC., Macaulay, SL., Masters, CL., Hill, AF., Aibl Research Group, T., (2014), Prognostic serum miRNA biomarkers associated with Alzheimer's disease shows concordance with neuropsychological and neuroimaging assessment. Molecular Psychiatry, Article in press(Article in press), 1-9, United Kingdom, DOI: 10.1038/mp.2014.127.
  56. Ellis, K., Szoeke, C., Bush, A., Darby, D., Graham, P., Lautenschlager, N., Macaulay, L., Martins, R., Maruff, P., Masters, C., McBride, S., Pike, K., Rainey-Smith, S., Rembach, A., Robertson, J., Rowe, C., Savage, G., Villemagne, V., Woodward, M., Wilson, W., Zhang, P., Ames, D., Aibl Research Group, T., (2014), Rates of diagnostic transition and cognitive change at 18-month follow-up among 1,112 participants in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL). International Psychogeriatrics, 26(4), 543-554, DOI: 10.1017/S1041610213001956.
  57. Lim, F., Lam, SM., Shui, G., Mondal, A., Ong, D., Duan, X., Creegan, R., Martins, I., Sharman, M., Taddei, K., Verdile, G., Wenk, M., Martins, R., (2013), Effects of a high-fat, high-cholesterol diet on brain lipid profiles in apolipoprotein E E3 and E4 knock-in mice. Neurobiology of Aging, 34(9), 2217-2224, United States.
  58. O' Bryant, S., Xiao, G., Edwards, M., Devous, M., Gupta, V., Martins, R., Zhang, F., Barber, R., (2013), Biomarkers of Alzheimer?s Disease Among Mexican Americans. Journal of Alzheimer's Disease, 34(4), 841-849, Netherlands, DOI: 10.3233/JAD-122074.
  59. Carrillo, M., Rowe, C., Szoeke, C., Masters, C., Ames, D., O'Meara, T., Macaulay, SL., Milner, A., Ellis, K., Maruff, P., Rainey-Smith, S., Martins, R., Bain, L., Head, R., (2013), Research and standardization in Alzheimer's trials: Reaching international consensus. Alzheimer's and Dementia, 9(2), 160-168, United States, DOI: 10.1016/j.jalz.2012.10.006.
  60. Lim, YY., Ellis, K., Harrington, K., Kamer, A., Pietrzak, R., Bush, A., Darby, D., Martins, R., Masters, C., Rowe, C., Savage, G., Szoeke, C., Villemagne, V., Ames, D., Maruff, P., (2013), Cognitive consequences of high a? amyloid in mild cognitive impairment and healthy older adults: Implications for early detection of Alzheimer's disease. Neuropsychology, 27(3), 322-332, United States, DOI: 10.1037/a0032321.
  61. Lim, YY., Jaeger, J., Harrington, K., Ashwood, T., Ellis, K., Stoffler, A., Szoeke, C., Lachovitzki, R., Martins, R., Villemagne, V., Bush, A., Masters, C., Rowe, C., Ames, D., Darby, D., Maruff, P., (2013), Three-month stability of the cogstate brief battery in healthy older adults, mild cognitive impairment, and Alzheimer's disease: results from the Australian imaging, biomarkers, and lifestyle-rate of change substudy (AIBL-ROCS). Archives of Clinical Neuropsychology, 28(4), 320-330, United Kingdom.
  62. Rowe, C., Bourgeat, P., Ellis, K., Brown, B., Yen Ying, L., Mulligan, R., Jones, G., Maruff, P., Woodward, M., Price, R., Robins, P., Tochon-Danguy, H., O'Keefe, G., Pike, K., Yates, P., Szoeke, C., Salvado, O., Macaulay, SL., O'Meara, T., Head, R., Cobiac, L., Savage, G., Martins, R., Masters, C., Ames, D., Villemagne, V., (2013), Predicting Alzheimer disease with beta-amyloid imaging: results from the Australian imaging, biomarkers, and lifestyle study of ageing. Annals of Neurology, 74(6), 905-913, USA, DOI: 10.1002/ana.24040.
  63. Moore, E., Mander, A., Ames, D., Kotowicz, M., Carne, R., Brodaty, H., Woodward, M., Boundy, K., Ellis, K., Bush, A., Faux, N., Martins, R., Szoeke, C., Rowe, C., Watters, D., (2013), Increased risk of cognitive impairment in patients with diabetes is associated with metformin. Diabetes Care, 36(10), 2981-2987.
  64. Buckley, R., Saling, M., Ames, D., Rowe, C., Lautenschlager, N., Macaulay, SL., Martins, R., Masters, C., O'Meara, T., Savage, G., Szoeke, C., Villemagne, V., Ellis, K., (2013), Factors affecting subjective memory complaints in the AIBL aging study: biomarkers, memory, affect, and age. International Psychogeriatrics, 25(8), 1307-1315.
  65. Frost, S., Kanagasingam, Y., Sohrabi, H., Taddei, K., Bateman, R., Morris, J., Benzinger, T., Goate, A., Masters, C., Martins, R., (2013), Pupil Response Biomarkers Distinguish Amyloid Precursor Protein Mutation Carriers from Non-Carriers. Current Alzheimer Research, 10(8), 790-796, Netherlands.
  66. Lim, YY., Villemagne, V., Laws, S., Ames, D., Pietrzak, R., Ellis, K., Harrington, K., Bourgeat, P., Salvado, O., Darby, D., Snyder, P., Bush, A., Martins, R., Masters, C., Rowe, C., Nathan, P., Maruff, P., (2013), BDNF Val66Met, Abeta amyloid, and cognitive decline in preclinical Alzheimer's disease. Neurobiology of Aging, 34(11), 2457-2464, United States.
  67. Lim, YY., Ellis, K., Harrington, K., Pietrzak, R., Gale, J., Ames, D., Bush, A., Darby, D., Martins, R., Masters, C., Rowe, C., Savage, G., Szoeke, C., Villemagne, V., Maruff, P., (2013), Cognitive Decline in Adults with Amnestic Mild Cognitive Impairment and High Amyloid-?: Prodromal Alzheimer's Disease?. Journal of Alzheimer's Disease, 33(4), 1167-1176, Netherlands.
  68. Foster, J., Albrecht, M., Savage, G., Lautenschlager, N., Ellis, K., Maruff, P., Szoeke, C., Taddei, K., Martins, R., Masters, C., Ames, D., (2013), Lack of reliable evidence for a distinctive e4-related cognitive phenotype that is independent from clinical diagnostic status: findings from the Australian Imaging, Biomarkers and Lifestyle Study. Brain: a journal of neurology , 136(7), 2201-16.
  69. Dore, V., Villemagne, V., Bourgeat, P., Fripp, J., Acosta, O., Chetelat, G., Zhou, L., Martins, R., Ellis, K., Masters, C., Ames, D., Salvado, O., Rowe, C., (2013), Cross-sectional and longitudinal analysis of the relationship between a? deposition, cortical thickness, and memory in cognitively unimpaired individuals and in Alzheimer disease. JAMA Neurology, 70(7), 903-911, United States, DOI: 10.1001/jamaneurol.2013.1062.
  70. Gardener, S., Rainey-Smith, S., Keogh, J., Mathieson, S., Martins, R., (2013), Dietary Patterns Associated with Alzheimer's Disease and Related Chronic Disease Risk: A Review. Alzheimer's Disease & Parkinsonism, Special(2013), online, online.
  71. Martins, I., Creegan, R., Lim, F., Martins, R., (2013), Molecular insights into appetite control and neuroendocrine disease as risk factors for chronic diseases in Western countries. Open Journal of Endocrine and Metabolic Diseases, 3(5A), 11-33, United States of America, DOI: 10.4236/ojemd.2013.35A002.
  72. Avdesh, ., Hoe, Y., Martins, R., Martin-Iverson, M., (2013), Pharmacological effects of cannabinoids on the reference and working memory functions in mice. Psychopharmacology, 225(2), 483-494, DOI: 10.1007/s00213-012-2834-6.
  73. Rembach, A., Doecke, JD., Roberts, BR., Watt, AD., Faux, NG., Volitakis, I., Pertile, K., Rumble, R., Trounson, B., Fowler, C., Wilson, W., Ellis, K.,Martins, R., Rowe, C., Villemagne, V., Ames, D., Masters, C., Bush, A., (2013), Longitudinal Analysis of Serum Copper and Ceruloplasmin in Alzheimer's Disease. Journal of Alzheimer's Disease, 34(1), 171-182, Netherlands.
  74. Benzinger, T., Blazey, T., Jack, C., Koeppe, R., Su, Y., Xiong, C., Raichle, M., Snyder, A., Ances, B., Bateman, R., Cairns, N., Fagan, A., Goate, A., Marcus, D., Aisen, P., Christensen, J., Ercole, L., Hornbeck, R., Farrar, A., Aldea, P., Jasielec, M., Owen, C., Xie, X., Mayeux, R., Brickman, A., McDade, E., Klunk, W., Mathis, C., Ringman, J., Thompson, P., Ghetti, B., Saykin, A., Sperling, R., Johnson, K., Salloway, S., Correia, S., Schofield, P., Masters, C., Rowe, C., Villemagne, V., Martins, R., Ourselin, S., Rossor, M., Fox, N., Cash, D., Weiner, M., Holtzman, D., Buckles, V., Moulder, K., Morris, J., (2013), Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease. Proceedings of the National Academy of Sciences of USA, 110(47), E4502-E4509, United States, DOI: 10.1073/pnas.1317918110.
  75. Valenzuela, M., Bartres-Faz, D., Bullmore, E., Fjell, A., Maletic-Savetic, M., Martins, R., Solowij, N., Yucel, M., (2013), Less is more: More thinking about less data: a perspective from the 2nd Provence Summer Workshop. Molecular Psychiatry, 18(5), 524-525, United Kingdom.
  76. Lim, YY., Pietrzak, RH., Ellis, KA., Jaeger, J., Harrington, K., Ashwood , T., Szoeke, C., Martins, R., Bush, AI., Masters, CL., Rowe, CC., Villemagne, VL., Ames, D., Darby, D., Maruff, P., (2013), Rapid Decline in Episodic Memory in Healthy Older Adults with High Amyloid-?. Journal of Alzheimer's Disease, 33(3), 675-679, Netherlands, DOI: 10.3233/JAD-2012-121516.
  77. Ellis, K., Lim, YY., Harrington, K., Ames, D., Bush, A., Darby, D., Martins, R., Masters, C., Rowe, C., Savage, G., Szoeke, C., Villemagne, V., Maruff, P., (2013), Decline in Cognitive Function over 18 Months in Healthy Older Adults with High Amyloid-?. Journal of Alzheimer's Disease, 34(2013), 861-871, Netherlands.
  78. Villemagne, V., Burhnham, S., Bourgeat, P., Brown, B., Ellis, KA., Salvado, O., Szoeke, C., Macaulay, L., Martins, R., Maruff, P., Ames, D., Rowe, C., Masters, C., (2013), Amyloid ? deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease : a prospective cohort study. The Lancet Neurology, 12(4), 357-367.
  79. Harrington, K., Lim, YY., Ellis, K., Copolov, C., Darby, D., Weinborn, M., Ames, D., Martins, R., Savage, G., Szoeke, C., Rowe, C., Villemagne, V., Masters, C., Maruff, P., (2013), The association of A? amyloid and composite cognitive measures in healthy older adults and MCI. International Psychogeriatrics, 25(10), 1667-1677, United Kingdom, DOI: 10.1017/S1041610213001087.
  80. Drummond, E., Muhling, J., Martins, R., Wijaya, L., Ehlert, E., Harvey, A., (2013), Pathology associated with AAV Mediated Expression of Beta Amyloid or C100 in Adult Mouse Hippocampus and Cerebellum. PLoS One, 8(3), e59166.
  81. Frost, S., Kanagasingam, Y., Sohrabi, H., Bourgeat, P., Villemagne, V., Rowe, C., Macaulay, SL., Szoeke, C., Ellis, K., Ames, D., Masters, C., Rainey-Smith, S., Martins, R., (2013), Pupil Response Biomarkers for Early Detection and Monitoring of Alzheimer's Disease. Current Alzheimer Research, 10(9), 931-939.
  82. Bharadwaj, P., Head, R., Martins, R., Raussens, V., Sarroukh, R., Jegasothy, H., Waddington, L., Bennett, L., (2013), Modulation of amyloid-? 1-42 structure and toxicity by proline-rich whey peptides. Food and Function, 4(1), 92-103, United Kingdom, DOI: 10.1039/c2fo30111c.
  83. Gupta, V., Sundaram, R., Martins, R., (2013), Multiplex biomarkers in blood. Alzheimer's Research & Therapy, 5(3), Article 31, United Kingdom, DOI: 10.1186/alzrt185.
  84. Burnham, S., Faux, N., Wilson, W., Laws, S., Ames, D., Bedo, J., Bush, A., Doecke, J., Ellis, K., Head, R., Jones, G., Kiiveri, H., Martins, R., Rembach, A., Rowe, C., Salvado, O., Macaulay, SL., Masters, C., Villemagne, V., (2013), A blood-based predictor for neocortical A-beta burden in Alzheimer's disease: results from the AIBL study. Molecular Psychiatry, 19(2014), 519-526, United Kingdom.
  85. Sharman, M., Moussavi Nik, S., Chen, M., Ong, D., Wijaya, L., Laws, S., Taddei, K., Newman, M., Lardelli, M., Martins, R., Verdile, G., (2013), The Guinea Pig as a Model for Sporadic Alzheimer's Disease (AD): The Impact of Cholesterol Intake on Expression of AD-Related Genes. PLoS One, 8(6), e66235.
  86. Frost, S., Kanagasingam, Y., Sohrabi, H., Vignarajan, J., Bourgeat, P., Salvado, O., Villemagne, V., Rowe, C., Macaulay, L., Szoeke, C., Ellis, K., Ames, D., Masters, C., Rainey-Smith, S., Martins, R., (2013), Retinal vascular biomarkers for early detection and monitoring of Alzheimer's disease. Translational Psychiatry, 3(February), 1-8, United Kingdom.
  87. Martins, I., Lim, F., Wilson, A., Laws, S., Martins, R., (2013), The acceleration of aging and Alzheimer?s disease through the biological mechanisms behind obesity and type II diabetes. Health, 5(5), 913-920, United States of America, DOI: 10.4236/health.2013.55121.
  88. Bharadwaj, P., Bates, K., Porter, T., Teimouri, E., Perry, G., Steele, JW., Gandy, S., Groth, D., Martins, R., Verdile, G., (2013), Latrepirdine: molecular mechanisms underlying potential therapeutic roles in Alzheimer?s and other neurodegenerative diseases. Translational Psychiatry, 3(2013), Article no. e332, London, UK, DOI: 10.1038/tp.2013.97.
  89. Sona, A., Zhang, P., Ames, D., Bush, AI., Lautenschlager, NT., Martins, R., Masters, CL., Rowe, CC., Szoeke, C., Taddei, K., Ellis, KA., (2012), Predictors of rapid cognitive decline in Alzheimer's disease: Results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of ageing. International Psychogeriatrics, 24(2), 197-204, DOI: 10.1017/S1041610211001335.
  90. Verdile, G., Laws, S., Henley, D., Ames, D., Bush, A., Ellis, K., Faux, N., Gupta, V., Li, Q., Masters, C., Pike, K., Rowe, C., Szoeke, C., Taddei, K., Villemagne, V., Martins, R., (2012), Associations between gonadotropins, testosterone and ? amyloid in men at risk of Alzheimer's disease. Molecular Psychiatry, 19(1), 69-75, United Kingdom, DOI: 10.1038/mp.2012.147.
  91. Gardener, S., Gu, Y., Rainey-Smith, S., Keogh, JB., Clifton, PM., Mathieson, SL., Taddei, K., Mondal, A., Ward, V., Scarmeas, N., Barnes, M., Ellis, K., Head, R., Masters, C0., Ames, D., Macaulay, S0., Rowe, C0., Szoeke, C., Martins, R., (2012), Adherence to a Mediterranean diet and Alzheimer's disease risk in an Australian population. Translational Psychiatry, 2(2012), e164, DOI: 10.1038/tp.2012.91.
  92. Steele, JW., Lachenmayer, ML., Ju, S., Stock, A., Liken, J., Kim, SH., Delgado, LM., Alfaro, IE., Bernales, S., Verdile, G., Bharadwaj, P., Gupta, V., Barr, R., Friss, A., Dolios, G., Wang, R., Ringe, D., Fraser, P., Westaway, D., St George-Hyslop, P0., Szabo, P., Relkin, N0., Buxbaum, J0., Glabe, C0., Protter, A0., Martins, R., Ehrlich, M0., Petsko, G0., (2012), Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model. Molecular Psychiatry, 1-9, United Kingdom, DOI: 10.1038/mp.2012.106.
  93. Steele, JW., Ju, S., Lachenmayer, M., Liken, J., Stock, A., Kim, SH., Delgado, L., Alfaro, I., Bernales, S., Verdile, G., Bharadwaj, P., Gupta, V., Barr, R., Friss, A., Dolios, G., Wang, R., Ringe, D., Protter, A., Martins, R., Ehrlich, M., Yue, Z., Petsko, G., Gandy, S., (2012), Latrepirdine stimulates autophagy and reduces accumulation of ?-synuclein in cells and in mouse brain. Molecular Psychiatry, 18(8), 882-888, United Kingdom, DOI: 10.1038/mp.2012.115.
  94. Lim, YY., Ellis, KA., Harrington, K., Ames, D., Martins, R., Masters, CL., Rowe, C., Savage, G., Szoeke, C., Darby, D., Maruff, P., (2012), Use of the CogState brief battery in the assessment of Alzheimer's disease related cognitive impairment in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. Journal of Clinical and Experimental Neuropsychology, 34(4), 345-358, DOI: 10.1080/13803395.2011.643227.
  95. Cyarto, EV., Lautenschlager, NT., Desmond, PM., Ames, D., Szoeke, C., Salvado, O., Sharman, M., Ellis, KA., Phal, PM., Masters, CL., Rowe, CC.,Martins, R., Cox, KL., (2012), Protocol for a randomized controlled trial evaluating the effect of physical activity on delaying the progression of white matter changes on MRI in older adults with memory complaints and mild cognitive impairment: The AIBL Active trial. BMC Psychiatry, 12(11 October 2012), Article 167, DOI: 10.1186/1471-244X-12-167.
  96. Acosta, O., Fripp, J., Dore, V., Bourgeat, P., Favreau, JM., Chetelat, G., Rueda, A., Villemagne, VL., Szoeke, C., Ames, D., Ellis, K., Martins, R., Masters, CA., Rowe, CA., Bonner, E., Gris, F., Xiao, D., Raniga, P., Barra, V., Salvado, O., (2012), Cortical surface mapping using topology correction, partial flattening and 3D shape context-based non-rigid registration for use in quantifying atrophy in Alzheimer's disease. Journal of Neuroscience Methods, 205(1), 96-109, DOI: 10.1016/j.jneumeth.2011.12.011.
  97. Bateman, RJ., Xiong, C., Benzinger, TL., Fagan, AM., Goate, A., Fox, NC., Marcus, DS., Cairns, NJ., Xie, X., Blazey, TM., Holtzman, DM., Santacruz, A., Buckles, V., Oliver, A., Moulder, K., Aisen, PM., Ghetti, B., Klunk, WM., McDade, E., Martins, R., Masters, CM., Mayeux, R., Ringman, JM., Rossor, MM., Schofield, PM., Sperling, RM., Salloway, S., Morris, JM., (2012), Clinical and biomarker changes in dominantly inherited Alzheimer's disease. New England Journal of Medicine, 367(9), 795-804, DOI: 10.1056/NEJMoa1202753.
  98. Chetelat, G., Villemagne, V., Villain, N., Jones, G., Ellis, K., Ames, D., Martins, R., Masters, C., Rowe, C., (2012), Accelerated cortical atrophy in cognitively normal elderly with high ?-amyloid deposition. Neurology, 78(7), 477-484, United States, DOI: 10.1212/WNL.0b013e318246d67a.
  99. Lim, Y., Ellis, K., Ames, D., Darby, D., Harrington, K., Martins, R., Masters, C., Rowe, C., Savage, G., Szoeke, C., Villemagne, V., Maruff, P., (2012), A? amyloid, cognition, and APOE genotype in healthy older adults. Alzheimer's and Dementia, 9(5), 538-545, United States, DOI: 10.1016/j.jalz.2012.07.004.
  100. Martins, I., Wilson, A., Lim, F., Laws, S., Fuller, S., Martins, R., (2012), Sirtuin-1 mediates the obesity induced risk of common degenerative diseases: Alzheimer?s disease, coronary artery disease and type 2 diabetes. Health, 4(12A), 1448-1456, United States, DOI: 10.4236/health.2012.412A209.
  101. Drummond, ES., Martins, R., Handelsman, DJ., Harvey, AR., (2012), Altered expression of Alzheimer's disease-related proteins in male hypogonadal mice. Endocrinology, 153(6), 2789-2799, DOI: 10.1210/en.2011-2003.
  102. Bharadwaj, P., Verdile, G., Barr, R., Gupta, V., Steele, J., Lachenmayer, L., Yue, Z., Ehrlich, M., Petsko, G., Ju, S., Ringe, D., Sankovich, S., Caine, J., Macreadie, I., Gandy, S., Martins, R., (2012), Latrepirdine (Dimebon?) enhances autophagy and reduces intracellular GFP-A?42 levels in yeast. Journal of Alzheimer's disease, 32(4), 949-967, Netherlands, DOI: 10.3233/JAD-2012-120178.
  103. Lim, YY., Ellis, KA., Pietrzak, RH., Ames, D., Darby, D., Harrington, K., Martins, R., Masters, CL., Rowe, C., Savage, G., Szoeke, C., Villemagne, V0., Maruff, P., (2012), Stronger effect of amyloid load than APOE genotype on cognitive decline in healthy older adults. Neurology, 79(16), 1645-1652, DOI: 10.1212/WNL.0b013e31826e9ae6.
  104. Barber, B., Ames, D., Ellis, K., Martins, R., Masters, C., Szoeke, C., (2012), Lifestyle and late life cognitive health: Sufficient evidence to act now?. International Psychogeriatrics, 24(5), 683-688, DOI: 10.1017/S1041610211002912.
  105. Brown, B., Peiffer, JJ., Martins, R., (2012), Multiple effects of physical activity on molecular and cognitive signs of brain aging: can exercise slow neurodegeneration and delay Alzheimer's disease?. Molecular Psychiatry, 18(8), 864-874, United Kingdom, DOI: 10.1038/mp.2012.162.
  106. Newman, M., Nornes, S., Martins, R., Lardelli, MT., (2012), Robust homeostasis of Presenilin1 protein levels by transcript regulation. Neuroscience Letters, 519(1), 14-19, DOI: 10.1016/j.neulet.2012.04.064.
  107. Brown, B., Peiffer, J., Taddei, K., Lui, J., Laws, S., Gupta, V., Taddei, T., Ward, V., Rodrigues, M., Burnham, S., Rainey-Smith, S., Villemagne, V., Bush, A., Ellis, K., Masters, C., Ames, D., Macaulay, L., Szoeke, C., Rowe, C., Martins, R., (2012), Physical activity and amyloid-? plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing. Molecular Psychiatry, 18(8), 875-881, United Kingdom.
  108. Sohrabi, H., Bates, K., Weinborn, M., Johnston, A., Bahramian, A., Taddei, K., Laws, S., Rodrigues, M., Morici, M., Howard, M., Martins, G., Mackay-Sim, A., Gandy, S., Martins, R., (2012), Olfactory discrimination predicts cognitive decline amongst community-dwelling older adults. Translational Psychiatry , 2(2012), art. no. e118 , DOI: 10.1038/tp.2012.43.
  109. Villain, N., Chetelat, G., Grassiot, B., Bourqeat, P., Jones, G., Ellis, K., Ames, D., Martins, R., Eustache, F., Salvado, O., Masters, C., Rowe, C., Villemagne, V., (2012), Regional dynamics of amyloid-? deposition in healthy elderly, mild cognitive impairment and Alzheimer's disease: A voxelwise PiB-PET longitudinal study. Brain: a journal of neurology , 135(7), 2126-2139.
  110. Brown, B., Peiffer, J., Sohrabi, H., Mondal, A., Gupta, V., Rainey-Smith, S., Taddei, K., Burnham, S., Ellis, K., Szoeke, C., Masters, CL., Ames, D., Rowe, C., Martins, R., (2012), Intense physical activity is associated with cognitive performance in the elderly. Translational Psychiatry, 2(2012), art. no. e191 , DOI: 10.1038/tp.2012.118.
  111. Hata, S., Taniguchi, M., Piao, Y., Ikeuchi, T., Fagan, A., Holtzman, D., Bateman, R., Sohrabi, H., Martins, R., Gandy, S., Urakami, K., Suzuki, T., (2012), Multiple ?-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer?s disease subjects. Molecular Neurodegeneration, 7(1), art. no. 16 , United Kingdom, DOI: 10.1186/1750-1326-7-16.
  112. Avdesh, ., Martin-Iverson, MT., Mondal, A., Chen, M., Askraba, S., Morgan, N., Lardelli, M., Groth, DM., Verdile, G., Martins, R., (2012), Evaluation of Color Preference in Zebrafish for Learning and Memory. Journal of Alzheimer's Disease, 28(2), 459-469, USA, DOI: 10.3233/JAD-2011-110704.
  113. Lau, S., Bates, K., Sohrabi, H., Rodrigues, M., Martins, G., Dhaliwal, S., Taddei, K., Laws, S., Martins, I., Mastaglia, F., Foster, J., Phillips, J., Martins, R., (2012), Functional effects of genetic polymorphism in inflammatory genes in subjective memory complainers. Neurobiology of Aging, 33(6), 1054-1056, United States, DOI: 10.1016/j.neurobiolaging.2010.09.003.
  114. Morris, JC., Aisen, PS., Bateman, RJ., Benzinger, TL., Cairns, NJ., Fagan, AM., Ghetti, B., Goate, AM., Holtzman, DM., Klunk, WE., McDade, E., Marcus, DS., Martins, R., Masters, CL., Mayeux, R., Oliver, A., Quaid, K., Ringman, JM., Rossor, MN., Salloway, S., Schofield, PR., Selsor, NJ., Sperling, RA., Weiner, MW., Xiong, C., Moulder, KL., Buckles, VD., (2012), Developing an international network for Alzheimer research: the Dominantly Inherited Alzheimer Network. Clinical Investigation, 2(10), 975-984, London, United Kingdom, DOI: 10.4155/cli.12.93.
  115. Doecke, J., Laws, S., Faux, N., Wilson, W., Burnham, S., Lam, P., Mondal, A., Bedo, J., Bush, A., Brown, B., De Ruyck, K., Ellis, K., Fowler, C., Gupta, V., Head, R., Macaulay, SL., Pertile, K., Rowe, C., Rembach, A., Rodrigues, M., Rumble, R., Szoeke, C., Taddei, K., Taddei, T., Trounson, B., Ames, D., Masters, C., Martins, R., (2012), Blood-Based Protein Biomarkers for Diagnosis of Alzheimer Disease. Archives of Neurology, 69(10), 1318-1325, United States, DOI: 10.1001/archneurol.2012.1282.
  116. Villemagne, VL., Pike, KE., Chetelat, G., Ellis, KA., Mulligan, RS., Bourgeat, P., Ackermann, U., Jones, G., Szoeke, C., Salvado, O., Martins, R., O'Keefe, G., Mathis, CA., Klunk, WE., Ames, D., Masters, CL., Rowe, CC., (2011), Longitudinal assessment of A? and cognition in aging and Alzheimer disease. Annals of Neurology, 69(1), 181-192, DOI: 10.1002/ana.22248.
  117. Kanyenda, L., Verdile, G., Boulos, S., Krishnaswamy, S., Taddei, K., Meloni, BP., Mastaglia, FL., Martins, R., (2011), The dynamics of CD147 in Alzheimer's disease development and pathology. Journal of Alzheimer's Disease, 26(4), 593-605, Netherlands, DOI: 10.3233/JAD-2011-110584.
  118. Chetelat, G., Villemagne, VL., Pike, KE., Ellis, KA., Bourgeat, P., Jones, G., O'Keefe, GJ., Salvado, O., Szoeke, C., Martins, R., Ames, D., Masters, CL., Rowe, CC., (2011), Independent contribution of temporal ?-amyloid deposition to memory decline in the pre-dementia phase of Alzheimer's disease. Brain, 134(3), 798-807, United Kingdom, DOI: 10.1093/brain/awq383.
  119. Mattsson, N., Andreasson, U., Persson, S., Arai, H., Batish, SD., Bernardini, S., Bocchio-Chiavetto, L., Blankenstein, MA., Carrillo, MC., Chalbot, S., Coart, E., Chiasserini, D., Cutler, N., Dahlfors, G., Duller, S., Fagan, AM., Forlenza, O., Frisone , GB., Galasko, D., Galimberti, D., Hampel, H., Handberg, A., Heneka, MT., Herskovits, AZ., Herukka , S., Holtzmann, DM., Humpel, C., Hyman, B., Iqbal, K., Jucker, M., Kaeser , S., Kaiser, E., Kapaki, E., Kidd, D., Kilvenyi, P., Knudsen, CS., Kummer, M., Lui, J., Llado, A., Lewczuk, P., Li, Q., Martins, R., Masters, C., McAuliffe, J., Mercken, M., Moghekar, A., Molinuevo, JL., Montine, TJ., Nowatzke, W., O'Brien, R., Otto, M., Paraskevas, GP., Parnetti, L., Petersen, RC., Prvulovic, D., De Reus, HP., Rissman, RA., Scarpini, E., Stefani, A., Soininen, H., Schroeder , J., Shaw, LM., Skinningsrud, A., Skrogstad, B., Spreer, A., Talib, L., Teunissen, C., Trojanowski, JQ., Tunami, H., Umek, RM., Van Broeck, B., Vanderstichele, H., Vecsei, L., Verbeek, M., Windisch, M., Zhang, J., Zetterberg, H., Blennow, K., (2011), The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers. Alzheimers and Dementia, 7(4), 386-395, United States, DOI: 10.1016/j.jalz.2011.05.2243.
  120. Ellis, KA., Rowe, CC., Szoeke, CE., Villemagne, VL., Ames, D., Chetelat, G., Martins, R., Masters, CL., Fripp, J., Acosta, O., Raniga, P., Bourgeat, PT., Salvado, O., (2011), Advances in structural and molecular neuroimaging in Alzheimer's disease. Medical Journal of Australia, 194(4), S20-S23, Australia.
  121. Lambert, J., Dallongeville, J., Ellis, KA., Schraen-Maschke, S., Lui, J., Laws, S., Dumont, J., Richard, F., Cottel, D., Berr, C., Ames, D., Masters, CL., Rowe, CC., Szoeke, C., Tzourio, C., Dartigues, J., Buee, L., Martins, R., Amouyel, P., (2011), Association of plasma A? peptides with blood pressure in the elderly. PLoS One, 6(4), e18536, DOI: 10.1371/journal.pone.0018536.
  122. Faux, NG., Ellis, KA., Porter, L., Fowler, CJ., Laws, S., Martins, R., Pertile, K., Rembach, A., Rowe, CC., Rumble, RL., Szoeke, C., Taddei, K., Taddei, T., Trounson, BO., Villemagne, VL., Ward, V., Ames, D., Masters, CL., Bush, A., (2011), Homocysteine, Vitamin B12, and Folic Acid Levels in Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Elderly: Baseline Characteristics in Subjects of the Australian Imaging Biomarker Lifestyle Study. Journal of Alzheimer's Disease, 27(4), 909-922 , Netherlands, DOI: 10.3233/JAD-2011-I10752.
  123. McBride, SJ., Szoeke, CE., Good, NM., Ames, D., Martins, R., Masters, CL., Maruff, PT., Rowe, CC., Savage, G., Ellis, KA., (2011), A web-based normative data tool for assessing cognitive performance in healthy older Australians. Medical Journal of Australia, 194(4), S12-S14, Australia.
  124. Avdesh, ., Wong, P., Martins, R., Martin-Iverson, MT., (2011), Memory function in a mouse genetic model of Alzheimer's disease. Journal of Alzheimer's Disease, 25(3), 433-444, Netherlands, DOI: 10.3233/JAD-2011-101944.
  125. Pike, K., Ellis, KA., Villemagne, VL., Good, N., Chetelat, G., Ames, D., Szoeke, C., Laws, S., Verdile, G., Martins, R., Masters, CL., Rowe, CC., (2011), Cognition and beta-amyloid in preclinical Alzheimer's disease: Data from the AIBL study. Neuropsychologia, 49(9), 2384-2390, DOI: 10.1016/j.neuropsychologia.2011.04.012.
  126. Gupta, V., Laws, S., Villemagne, V., Ames, D., Bush, A., Ellis, K., Lui, J., Masters, C., Rowe, C., Szoeke, C., Taddei, K., Martins, R., (2011), Plasma apolipoprotein e and Alzheimer disease risk: The AIBL study of aging. Neurology, 76(12), 1091-1098, DOI: 10.1212/WNL.0b013e318211c352.
  127. Newman, M., Verdile, G., Martins, R., Lardelli, M., (2011), Zebrafish as a tool in Alzheimer's disease research. BBA: Molecular Basis of Disease, 1812(3), 346-352, DOI: 10.1016/j.bbadis.2010.09.012.
  128. Sittironnarit, G., Ames, D., Bush, A., Faux, N., Flicker, L., Foster, J., Hilmer, S., Lautenschlager, N., Maruff, P., Masters, C., Martins, R., Rowe, C., Szoeke, C., Ellis, K., (2011), Effects of Anticholinergic Drugs on Cognitive Function in Older Australians: results from the AIBL study. Dementia and Geriatric Cognitive Disorders, 31(3), 173-178, DOI: 10.1159/000325171.
  129. Wahjoepramono, EJ., Wijaya, L., Taddei, K., Bates, K., Howard, M., Martins, G., De Ruyck, K., Matthews, P., Verdile, G., Martins, R., (2011), Direct Exposure of Guinea Pig CNS to Human Luteinizing Hormone Increases Cerebrospinal Fluid and Cerebral Beta Amyloid Levels. Neuroendocrinology: international journal for basic and clinical studies on neuroendocrine relationships, 94(4), 313-322, DOI: 10.1159/000330812.