Education

Biography

Ranran Wu received her Ph.D. degree in Chemistry from Wayne State University. She is currently a Assistant Professor at University of Pennsylvania. So far she has 20 publications in total, with 12 of them being the first-author publications. She is also serving as a reviewer/editorial member for several research journals.

Research Interest

Research interests are Analytical chemistry, mass spectrometry, spectroscopy, proteomics, metabolomics, and nucleic acids research.

Scientific Activities

Awards and honors

• Thomas C. Rumble University Graduate Fellowship: Fall 2010–Winter 2011
• Graduate School Summer Dissertation Fellowship: Summer 2015
• David F. Boltz Analytical Award 2015
• Michigan Mass Spectrometry Discussion Group Symposium Poster Award 2015

Publications

1. “IRMPD Action Spectroscopy of Alkali Metal Cation-Cytosine Complexes: Effects of Alkali Metal Cation Size on Gas Phase Conformations,” Bo Yang, R. R. Wu, N. C. Polfer, G. Berden, J. Oomens, and M. T. Rodgers, J. Am. Soc. Mass Spectrom. 2013, 24, 1523-1533.
2. “Infrared Multiple Photon Dissociation Action Spectroscopy of Proton-Bound Dimers of Cytosine and Modified Cytosines: Effects of Modifications on Gas Phase Conformations,” Bo Yang, R. R. Wu, G. Berden, J. Oomens, and M. T. Rodgers, J. Phys. Chem. B 2013, 117, 14191-14201.
3. “Hydrogen Bond Stabilization Energies of Proton-Bound Homodimers Determined by Guided Ion Beam Tandem Mass Spectrometry: Application to Cytosine and 5-substituted Cytosines,” Bo Yang, R. R. Wu, and M. T. Rodgers, Anal. Chem. 2013, 85, 11000-11006.
4. “Gas-Phase Conformations and Energetics of Protonated 2'-Deoxyguanosine and Guanosine: IRMPD Action Spectroscopy and Theoretical Studies,” R. R. Wu, Bo Yang, G. Berden, J. Oomens, and M. T. Rodgers, J. Phys. Chem. B 2014, 118, 14774-14784.
5. “Gas-Phase Conformations and Energetics of Protonated 2'-Deoxyadenosine and Adenosine: IRMPD Action Spectroscopy and Theoretical Studies,” R. R. Wu, Bo Yang, G. Berden, J. Oomens, and M. T. Rodgers, J. Phys. Chem. B 2015, 119, 2795-2805.
6. “Infrared Multiple Photon Dissociation Action Spectroscopy of Sodium Cationized Halouracils: Effects of Sodium Cationization and Halogenation on Gas-Phase Conformation,” C. M. Kaczan, A. I. Rathur, R. R. Wu, Y. Chen, C. A. Austin, G. Berden, J. Oomens, and M. T. Rodgers, Int. J. Mass Spectrom. 2015, 378, 76-85. (Veronica M. Bierbaum Honor Issue)
7. “N3 and O2 Protonated Tautomeric Conformations of 2'-Deoxycytidine and Cytidine Coexist in the Gas Phase,” R. R. Wu, Bo Yang, C. E. Frieler, G. Berden, J. Oomens, and M. T. Rodgers, J. Phys. Chem. B 2015, 119, 5773-5784.
8. “Guided Ion Beam and Computational Studies of the Decomposition of a Model Thiourea Protein Cross-Linker,” R. Wang, B. Yang, R. R. Wu, M. T. Rodgers, M. Schäfer, and P. B. Armentrout, J. Phys. Chem. B 2015, 119, 3727-3742.
9. “Diverse Mixtures of 2,4-Dihydroxy Tautomers and O4 Protonated Conformers of Uridine and 2'-Deoxyuridine Coexist in the Gas Phase,” R. R. Wu, Bo Yang, C. E. Frieler, G. Berden, J. Oomens, and M. T. Rodgers, Phys. Chem. Chem. Phys. 2015, 17, 25978-25988.
10. “Base-Pairing Energies of Proton-Bound Dimers and Proton Affinities of 1-Methyl-5-Halocytosines: Implications for the Effects of Halogenation on the Stability of the DNA i-motif,” Bo Yang, R. R. Wu, and M. T. Rodgers, J. Am. Soc. Mass Spectrom. 2015, 26, 1469-1482.
11. “2,4-Dihydroxy and O2 Protonated Tautomers of dThd and Thd Coexist in the Gas Phase: Methylation Alters Protonation Preferences vs dUrd and Urd,” R. R. Wu, Bo Yang, C. E. Frieler, G. Berden, J. Oomens, and M. T. Rodgers, J. Am. Soc. Mass Spectrom. 2016, 27, 410-412.
12. “Mechanisms and Energetics for N-Glycosidic Bond Cleavage of Protonated 2'-Deoxyguanosine and Guanosine,” R. R. Wu, Yu Chen and M. T. Rodgers, Phys. Chem. Chem. Phys. 2016, 18, 2968-2980.
13. “N3 Protonation Induces Base Rotation of 2'-Deoxyadenosine-5'-Monophosphate and Adenine-5'-Monophosphate,” R. R. Wu, C. C. He, L. A. Hamlow, Y.-w. Nei, G. Berden, J. Oomens, and M. T. Rodgers, J. Phys. Chem B 2016, 120, 4616-4624.
14. “O2 Protonation Controls Threshold Behavior for N-Glycosidic Bond Cleavage of Protonated Cytosine Nucleosides,” R. R. Wu, and M. T. Rodgers, J. Phys. Chem. B 2016, 120, 4803-4811.
15. “Protonation Induces Base Rotation of Purine Nucleotides pdGuo and pGuo,” R. R. Wu, C. C. He, L. A. Hamlow, Y.-w. Nei, G. Berden, J. Oomens, and M. T. Rodgers, Phys. Chem. Chem. Phys. 2016, 18, 15081-15090.
16. “Mechanisms and Energetics for N-Glycosidic Bond Cleavage of Protonated Adenine Nucleosides: N3 Protonation Induces Base Flipping and Enhances N-Glycosidic Bond Stability,” R. R. Wu and M. T. Rodgers, Phys. Chem. Chem. Phys. 2016, 18, 16021-16032.
17. “Thermodynamics and Mechanisms of Protonated Asparaginyl-Glycine Decomposition,” G. C. Boles, R. R. Wu, M. T. Rodgers and P. B. Armentrout, J. Phys. Chem. B 2016, 120, 6525-6545.
18. “Tautomerization Lowers the Activation Barriers for N-Glycosidic Bond Cleavage of Protonated Uridine and 2'-Deoxyuridine,” R. R. Wu and M. T. Rodgers, Phys. Chem. Chem. Phys., 2016, 18, 24451-24459.
19. “N3 and O2 Protonated Conformers of the Cytosine Mononucleotides Coexist in the Gas Phase,” R. R. Wu, L. A. Hamlow, C. C. He, Y.-w. Nei, G. Berden, J. Oomens, and M. T. Rodgers, J. Am. Soc. Mass Spectrom. 2017, 28, 1638-1646.
20. “Influence of Transition Metal Cationization versus Sodium Cationization and Protonation on the Gas-Phase Tautomeric Conformations and Stability of Uracil: Application to [Ura+Cu]+ and [Ura+Ag]+,” T. E. Akinyemi, R. R. Wu, Y.-w. Nei, N. A. Cunnigham, H. A. Roy, J. D. Steill, G. Berden, J. Oomens, M. T. Rodgers, J. Am. Soc. Mass Spectrom., 2017, in press.
21. “The Intrinsic Basicity of the Phosphate Backbone Exceeds that of Uracil and Thymine Residues: Protonation of the Phosphate Moiety is Preferred over the Nucleobase for pdThd and pUrd,”, R. R. Wu, L. A. Hamlow, C. C. He, Y.-w. Nei, G. Berden, J. Oomens, and M. T. Rodgers, Phys. Chem. Chem. Phys., 2017, submitted.