Mine Yarım
Mine Yarım
Professor

Department of Pharmaceutical Chemistry
Yeditepe University
TURKEY

Education

  • March 2002 to August 2004, Postdoctoral Fellow, Department of Applied Biosciences Swiss Federal Institute of Technology, Zürich, Switzerland.
  • Ph. D. Degree (2000), Department of Pharmaceutical Chemistry, Faculty of Pharmacy,Hacettepe University
  • M. Sci. Degree (1995), Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry
  • B. Pharm. Degree (1993), Hacettepe University, Faculty of Pharmacy

 

Biography

Prof. Dr. Mine Yarim, graduated from Hacettepe University, Ankara (BS. Pharmacy 1993, M. Sc. Pharmaceutical Chemistry 1995) and received Ph. D. on Pharmaceutical Chemistry (2000) from Hacettepe University, Ankara, Turkey. She was postdoctoral fellow with Prof. Gerd Folkers at ETH-Zurich, Switzerland. She has been working at Yeditepe University, Faculty of Pharmacy since 2005. Her research interests are molecular interaction between bioactive molecules and their targets. Specially interested in 3D-QSAR approaches, docking and structure based drug design.

 

Research Interest

  • Computational Drug Design Methods; Quantitative Structure-Activity Relationships, Molecular Modelling Techniques.
  • Enantioseparations by high-performance liquid chromatography (HPLC)
  • Analytical and preparative HPLC
  • Pharmaceutical analysis
  • Synthesis of chiral stationary phases for HPLC
  • Synthesis and structural elucidation of some new drugs having anticancer, calcium antagonist, anti-inflammatory and antimicrobial activity

 

Professional Activities:

2005 to present Associate Professor Faculty of Pharmacy, Department of Pharmaceutical Chemistry
September 2012  Title of Professor Pharmaceutical Chemistry

 

Publications

  1. Kendi, E., S., Saraç, M., Yarım, M., Ertan, M., Läge ve B., Krebs, “4-(2-Methylphenyl)-1,2,3,4,5,6,7,8-octahydroquinazoline-2,5-dione (I) and 4-(4-chlorophenyl)-1,2,3,4,5,6,7,8-octahydroquinazoline-2,5-dione  (II),”  Cryst. Res. Technol.  32, 857-863 (1997).
  2. Saraç, S., M., Yarım, M., Ertan, K., Erol ve Y., Aktan, “4-Aryl-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline-2-thione derivatives: Synthesis, enantiomeric separation and in vitro screening as calcium antagonists,” Boll. Chim. Farmaceutico, 136, 657-664 (1997).
  3. Saraç, S., M., Yarım, M., Ertan, S., Boydağ ve K., Erol,” Synthesis, chemical and pharmacological properties of some 4-aryl-1,2,3,4,5,6,7,8-octahydroquinazoline-2,5-diones,” Pharmazie 53, 91-94 (1998).
  4. Saraç, S., M., Yarım ve M., Ertan, “Analytical resolution of 4-aryl-1,2,3,4,5,6,7,8-octahydroquinazoline-2-thiones using a cellulose chiral stationary phase,” Analytical Letters 32, 1245-1254 (1999).
  5. Yarım, M., S., Saraç, M., Ertan, Ö.S., Batu ve K., Erol, “Synthesis, structural elucidation and pharmacological properties of some 5-acetyl-3,4-dihydro-6-methyl-4-(substituted phenyl)-2(1H)-pyrimidinones,” Il Farmaco 54, 359-363 (1999).
  6. Tozkoparan, B., M., Yarım, S., Saraç, M., Ertan, P., Kelicen, G., Altınok ve R., Demirdamar, “Studies on synthesis, chromatographic resolution and antiinflammatory activities of some 2-thioxo-1,2,3,4-tetrahydropyrimidines and their condensed derivatives,” Arch. Pharm. Pharm. and Med. Chem. 333, 415-420 (2000).
  7. Saraç, S., M., Yarım, M., Ertan, F.S., Kılıç ve K., Erol, “4-Aryl-6,6-dimethyl-1,2,3,4,5,6,7,8-octahydroquinazoline-2,5-diones: Synthesis, chromatographic resolution and pharmacological activity,” Pharmazie 56, 298-302 (2001).
  8. Candan, M.M., E., Kendi, M., Yarım, S., Saraç ve M., Ertan, “Crystal structure of 1,7,7-trimethyl-4-(4-methylphenyl)-1,2,3,4,5,6,7,8-octahydroquinazoline-2,5-dione,” Analytical Sciences 17, 681-682 (2001).
  9. Candan, M.M., E., Kendi, M., Yarım, S., Saraç ve M., Ertan, “Crystal structure of 1,7,7-trimethyl-4-(4-bromophenyl)-1,2,3,4,5,6,7,8-octahydroquinazoline-2,5-dione,” Analytical Sciences 17, 1023-1024 (2001).
  10. Yarım, M., B., Tozkoparan, S., Saraç, M., Ertan, B., Özçelik ve U., Abbasoğlu, “Studies on new 2-thioxo-1,2,3,4-tetrahydropyrimidines and their condensed derivatives,” FABAD J. Pharm. Sci. 27, 65-75 (2002).
  11. Yarım, M., S., Saraç, M., Ertan, F.S., Kılıç ve K., Erol, “Synthesis, enantioseparation and pharmacological activity of 4-aryl-7,7-dimethyl-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline-2-thiones,”  Arzneim. Forsch./Drug Res. 52, 27-33 (2002).
  12. Çalış, Ü., M., Yarım, M., Köksal ve M., Özalp, “Synthesis and antimicrobial activity evaluation of some new adamantane derivatives,” Arzneim. Forsch./Drug Res. 52, 778-781 (2002).
  13. Yarım, M. ve S., Saraç, “Separation of the enantiomers of 4-aryl-7,7-dimethyl/1,7,7-trimethyl-1,2,3,4,5,6,7,8-octahydroquinazoline-2,5-diones by chiral HPLC,” Chromatographia 56, 307-312 (2002).
  14. Yarım, M., S., Saraç, M., Ertan, F.S., Kılıç ve K., Erol, “Synthesis and in vitro calcium antagonist activity of 4-aryl-7,7-dimethyl / 1,7,7-trimethyl-1,2,3,4,5,6,7,8-octahydro-quinazoline-2,5-dione derivatives,” Il Farmaco 58, 17-24(2003).
  15. Yarım, M., S., Moro, B., Hagenbuch, R., Huber, P., Meier-Abt, C., Kaseda, T., Kashima ve G., Folkers, “Application of QSAR Analysis to Organic Anion Transporting Polypeptide 1a5 (Oatp1a5) Substrates,” Bioorganic&Medicinal Chemistry 13, 463-471 (2005).
  16. Yarim, M., M. Koksal, D. Schepmann ve B. Wünch “Synthesis and in vitro evaluation of novel indole based sigma receptors ligands”, Chem. Biol. Drug Des., 78, 869-875 (2011).
  17. Koksal, M., I. Ozkan, M. Yarim, S. S. Bilge ve D. D. Erol “Studies on Synthesis, and Anti-inflammatory Activities of Novel 1,2,4-Triazolo[3,4-b]-1,3,4-thiadiazines”, Rev. Chim. (Bucuresti), 62, 1069-1072 (2011).
  18. Koksal-Akkoc, M., , M. Yarim-Yüksel, İ. Durmaz ve R. Çetin-Atalay “Design, synthesis  and biological evaluation of indole-based 1,4-disubstitutedpiperazines as cytotoxic agents”, Turkish J. Chemistry, 36, 515-525 (2012).
  19. Koksal, M., M. Yarim, İ. Durmaz ve R. Çetin-Atalay “Synthesis and cytotoxic activity of novel 3-methyl-1-[(4-substitutedpiperazin-1-yl)methyl]-1H-indole derivatives”, ArzneimForsch /DrugRes, 62, 1-6 (2012).
  20. Yarim, M., Koksal, M., Yarim, İ. Durmaz ve R. Çetin-Atalay “Cancer Cell Cytotoxicities of 1-(4-substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine Derivatives”, Int. J. Mol. Sci. 13, 8071-8085 (2012)
  21. Gurdal, E.E., Yarim M., Durmaz I., Cetin-Atalay R., Cytotoxic activities of some novel benzhydrylpiperazine derivatives, Drug Res, 63:03 (2013) 121-8.
  22. Koksal, M., Yarim, M., Erdal, A. ve A. Bozkurt “Synthesis and Anti-inflammatory Activities of Novel 5-(3,4-dichlorophenyl)-3-[(4-substitutedpiperazin-1-yl)methyl]-1,3,4-oxadiaxole-2(3H)-thiones”, Drug Res (Stuttg), 64(2), 66-72 (2014).
  23. Gurdal EE, Durmaz I, Cetin-Atalay R, Yarim M. Cytotoxic activities of some benzothiazole-piperazine derivatives. J. Enz. Inh. Med. Chem., Early Online 1-6, 2014.
  24. Gurdal EE, Durmaz I, Cetin-Atalay R, Yarim M. Synthesis and cytotoxicity studies of novel benzhydrylpiperazine carboxamide and thioamide derivatives. J. Enz. Inh. Med. Chem., 29(2):205-214, 2014.

 

Autoimmune Journal Flyer