Lee Chi, PhD
Lee Chi, PhD
Professor of Pharmaceutical Sciences

University of Missouri


  • B.S. in Pharmacy, Seoul National University, February, 1981
  • M.S. in Pharmacy, Seoul National University, February, 1985
  • M.S. in Pharmacokinetics, University of Washington, 1990
  • Ph.D. in Pharmaceutical Sciences, Rutgers University-College of Pharmacy, 1995
  • Post-Doc in Cardiology/Pathology, the University of Michigan, 1997


CHI H. LEE, PhD, is Professor of Pharmaceutical Sciences at the University of Missouri-Kansas City, where he teaches undergraduate and graduate pharmacy courses. His research focuses on elucidation of pathological mechanisms and formulation development of microbicidal and cardiovascular devices.

Research Interest

  • Development and evaluation of cardiovascular device/scaffold/stent
  • Development and evaluation of transdermal/transmucosal/implantable polymer-based systems for delivery of drugs, proteins and gene
  • Mechanistic studies on the calcium related regulation and transporter involved pathology
  • The role of endogens, proteins and biomarkers in the areas of cardiovascular, sexually transmitted diseases and skin/cervical/breast cancer.
  • Development of Pharmacokinetic/Pharmacodynamic computer-simulated and data mining/QSAR models
  • Bioengineering and bioinformatics

Professional Activities:

9/2011 Present Professor, College of Pharmacy, University of Missouri, Kansas City, MO
9/2005 – 8/2011 Associate Professor, College of Pharmacy, University of Missouri, Kansas City, MO
9/1999 – 8/2005 Assistant Professor, College of Pharmacy, University of Missouri, Kansas City, MO 
12/1998 –8/1999 Assistant Professor, College of Pharmacy, Northeast Louisiana University, Monroe, LA
9/1997–11/1998 Research Scientist in Bristol-Myers Squibb PRI
10/1995–9/1997 Postdoc Fellow in Department of Pediatric Cardiology in Medical School and Department of Pharmaceutics in College of Pharmacy, The University of Michigan, Ann Arbor, MI
11/1994 –9/1995 Parke-Davis Graduate Research Fellowship. The Rutgers University, New Brunswick,NJ
5/1991–11/1994 NIH Graduate Assistantship, The Rutgers University, New Brunswick, NJ
9/1986– 8/1990 Graduate Research fellow in Department of Pharmaceutics, The University of Washington, Seattle, WA


Honors and Awards



  • Advanced Drug Delivery. John Wiley & Sons, Inc. Co-Edited by AM Mitra, C.H. Lee and K Cheng; 2013

Book Chapter

  • Y.W. Chien and C.H. Lee: Drug delivery, Vaginal Route. Encyclopedia of Pharmaceutical Technology, 4th Edition, 1236-1259, 2013 http://www.tandfonline.com/doi/book/10.1081/E-EPT4
  • C.H. Lee: Characterization of nitric oxide delivery systems produced by various nanotechnologies in ‘Nitric Oxide: Methods and Protocols’ edited by J Coulter, Human Press. 704: 169-85, 2011
  • C.H. Lee and N Giri: Design of Stimulus-sensitive Drug Delivery Systems. in ‘Drug Delivery and Development of Anti-HIV Microbicides’ edited by José das Neves & Bruno Sarmento (Pan Stanford Publishing: ISBN 9789814463560 Cat# N11022). Chapter 10: 377-413, 2014
  • C.H. Lee and Yugyung Lee. Chapter 8: Collagen based formulations for wound healing applications. In ‘Wound healing biomaterials Vol 2: functional biomaterials’. Elsevier 2015


  1. W Wang, Y Lee, C. H. Lee: Review: Effects of NO on Stem Cell Therapy, JBA-D-15-00045R1, In Print, Biotechnology Advances (2015)
  2. Y Lee, A Khemka, G Acharya, N Giri and C. H. Lee; A Cascade Computer Model for Microbicide Diffusivity from Mucoadhesive Formulations, BioMedCentral 16:263 (DOI: 10.1186/s12859-015-0684-z) (2015)
  3. Byeongtaek Oh and Russell B Melchert, C. H. Lee: Bio-inspired Robust Hydrogel for the Delivery of Mesenchymal Stem Cells. DOI: 10.1007/S11095-015-1698-Y, ONLINE APRIL, Pharmaceutical Research (2015)
  4. Byeongtaek Oh and C. H. Lee: A Smart Mannosylated-reduced Graphene Oxides for Eradication of Macrophage Ablation in Inflammatory Atherosclerosis. Molecular Pharmaceutics (2015)
  5. Byeongtaek Oh and C. H. Lee: Nanofiber-coated Drug Eluting Stent for the Stabilization of Mast Cells: Pharmaceutical Research, 31: 2463-2478 (2014)
  6. Gayathri Acharya, Matthew Armstrong, Chris McFall, Rachael W. Quinn, Stephen L. Hilbert, Gabriel L. Converse, Peter B. Toth, Ashley K. Sherman, C.H. Lee, Gary K. Lofland, Richard A. Hopkins: Calcium and Phosphorus Concentrations in Native and Decellularized Semilunar Valve Tissues. Journal of Heart Valve Disease. 23(3) 259-270 (2014)
  7. Byeongtaek Oh and C. H. Lee: Nanofiber Approach to the Development of Advanced Cardiovascular Stent: Molecular Pharmaceutics, 10 (12), 4432–4442 (2013)
  8. Byeongtaek Oh and C. H. Lee: Review: Nanofiber for Cardiovascular Tissue Engineering: Expert Opinion on Drug Delivery, 10(11): 1565-1582 (2013) Read More: http://informahealthcare.com/doi/abs/10.1517/17425247.2013.830608
  9. Yi Liu, W Wang, G Acharya, Y-B Shim, ES Choe, C. H. Lee: Advanced Stent Coating for Drug Delivery and Biocompatibility. J Nanoparticle Research. 15 (10):1962 (2013)
  10. Y Lee, S. Jana, G Acharya and C. H. Lee: Computational Analysis and Predictive Modeling of Polymorph Descriptors. Chemistry Central Journal. 7:23, 2013 (DOI: 10.1186/1752-153X-7-23)
  11. W Wang, Y Lee, C. H. Lee: Review: The physiological and computational approach for atherosclerosis treatment. Int J of Cardiology. 167: 1664–1676 (2013) (online 23 October, 2012 (DOI:10.1016/j.ijcard.2012.09.195)
  12. G Acharya, Y Lee, C. H. Lee: Optimization of Cardiovascular Stent against Restenosis: Factorial Design Based Statistical Analysis of Polymer Coating Conditions. PLoS ONE 7(8): e43100 (2012)
  13. G Acharya, R Hopkins and C.H. Lee: The Effects of Advanced Polymeric Matrix on Cardiovascular Complications. J Biomedical Material Research. 100A (5): 1151-1159 (2012)
  14. Y Liu, G Acharya and C. H. Lee: The Effects of DAS on Cardiovascular Complications. J Biomedical Material Research. 99(3):485-92 (2011)
  15. C. H. Lee: Review: Treatment of Blood Flow Abnormality using Mucosal Delivery of Nitric Oxide. Drug Delivery and Translational Research. 1(3):201–208 (2011)
  16. JW Yoo, N Giri and C. H. Lee: pH-sensitive Eudragit Nanoparticles for Mucosal Drug Delivery. Int J Pharmaceutics. 403: 262-7 (2011)
  17. S Cheeti and C. H. Lee: The Involvement of Intracellular Calcium in the Regulation of MCT-Mediated Drug Uptake by HeLa Cells. Molecular Pharmaceutics. 7 (1): 169–176 (2010).
  18. M Changez, N-G Kang, C H. Lee and J-S Lee. Reversible and pH Sensitive Vesicles from Amphiphilic Homopolymer Poly(2-(4-vinylphenyl)pyridine). Small (Small-Journal), 6(1): 63-68 (2010)
  19. JW Yoo, ES Choe, SM Ahn and C. H. Lee: Pharmacological activity and protein phosphorylation caused by nitric oxide-releasing microparticles. Biomaterials. 31: 552-558 (2010).
  20. JW Yoo, J-S Lee and C. H. Lee: Characterization of nitric oxide-releasing microparticles for the mucosal delivery. J Biomedical Material Research. (Published Online: 25 March 2009) 92 (4): 1233-1243 (2010)
  21. C. H. Lee: Review: Physiological Variables in Heart Valve Substitute Calcification. Expert Opinion on Biological Therapy. 9(8) 1031-1042 (2009)
  22. JW Yoo, G Acharya and C. H. Lee: In vivo evaluation of vaginal films for mucosal delivery of nitric oxide. Biomaterials. 30:3978-3985 (2009)
  23. C. H. Lee, V. Moturi and Y. Lee: Thixotropical property in Pharmaceutical formulations. J Cont Rel, 136: 89-98 (2009) Cited by 91 - Related articles (as of February 18, 2015)
  24. J.G. Park, Q.Ye, E.M. Topp, C.H. Lee, E.Kostoryz, A Mirsa and P Spencer: Dynamic mechanical analysis and esterase degradation of dentin adhesives containing a branched methacrylate, J Biomedical Material Research. 91B: 61-70 (2009)
  25. M. S. Rahman, M Changez, JW Yoo, C. H. Lee, S Samal, and JS Lee. Synthesis of Amphiphilic Miktoarm Star Copolymers of Poly(n-hexylisocyanate) and Poly(ethylene glycol) through Reaction with the Active Methylene Group. Macromolecules 41 (19):7029-32 (2008)
  26. K Dharmala, JW Yoo and C. H. Lee: Development of Chitosan-SLN microparticles for chemotherapy: In vitro approach through efflux transporter modulation. J Cont Rel, 131:190-197 (2008)
  27. H Youn, K Hong, JW Yoo and C. H. Lee. ICAM-1 Expression in vaginal cells as a potential biomarker for inflammatory response. Biomarker 13 (3) 257 - 269 (2008)
  28. Y Lee, A Khemka, JW Yoo and C. H. Lee: Assessment of Diffusion Coefficient from Mucoadhesive Barrier Devices using artificial neural networks. Int J Pharm 351: 119-126 (2008)
  29. BK Warrier, R Mallipeddi, JW Yoo and C. H. Lee: Effects of the Surface pH on Interfacial Interactions of Collagen-elastin matrix. Journal Applied Biomaterials and Biomechanics (JABM) 5(3) 140-148 (2007)
  30. Y Lee, K Dharmala and C. H. Lee: An Intelligent Data Mining Model approach for adverse effects of Hormone Replacement Therapy. Methods of Information in Medicine, 46(1):5-18 (2007)
  31. S Cheeti, B K. Warrier and C. H. Lee: The Role of Monocarboxylat Transporters in Uptake of Lactic Acid in HeLa Cells. Int J Pharm. 325: 48-54 (2006)
  32. JW Yoo and C. H. Lee: Drug Delivery Systems for Hormone Therapy” J Cont Rel, 112: 1-14 (2006)
  33. JW Yoo, K Dharmala and C. H. Lee: The physicodynamic properties of mucoadheisve polymeric films developed as female controlled drug delivery system. Int J Pharm. 309 (1-2) 139-149 (2006)
  34. C.H. Lee, A. Singla, and Y. Lee; Biomedical application of Collagen. Int J Pharmaceutics. 221 (1-2), 1-22 (2001) (-Cited by 1155 - Related articles as of September 18, 2015)






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