Professor of Pharmaceutical Sciences
University of Missouri
USA
Education
- B.S. in Pharmacy, Seoul National University, February, 1981
- M.S. in Pharmacy, Seoul National University, February, 1985
- M.S. in Pharmacokinetics, University of Washington, 1990
- Ph.D. in Pharmaceutical Sciences, Rutgers University-College of Pharmacy, 1995
- Post-Doc in Cardiology/Pathology, the University of Michigan, 1997
Profile
CHI H. LEE, PhD, is Professor of Pharmaceutical Sciences at the University of Missouri-Kansas City, where he teaches undergraduate and graduate pharmacy courses. His research focuses on elucidation of pathological mechanisms and formulation development of microbicidal and cardiovascular devices.
Research Interest
- Development and evaluation of cardiovascular device/scaffold/stent
- Development and evaluation of transdermal/transmucosal/implantable polymer-based systems for delivery of drugs, proteins and gene
- Mechanistic studies on the calcium related regulation and transporter involved pathology
- The role of endogens, proteins and biomarkers in the areas of cardiovascular, sexually transmitted diseases and skin/cervical/breast cancer.
- Development of Pharmacokinetic/Pharmacodynamic computer-simulated and data mining/QSAR models
- Bioengineering and bioinformatics
Professional Activities:
9/2011 | Present Professor, College of Pharmacy, University of Missouri, Kansas City, MO |
9/2005 – 8/2011 | Associate Professor, College of Pharmacy, University of Missouri, Kansas City, MO |
9/1999 – 8/2005 | Assistant Professor, College of Pharmacy, University of Missouri, Kansas City, MO |
12/1998 –8/1999 | Assistant Professor, College of Pharmacy, Northeast Louisiana University, Monroe, LA |
9/1997–11/1998 | Research Scientist in Bristol-Myers Squibb PRI |
10/1995–9/1997 | Postdoc Fellow in Department of Pediatric Cardiology in Medical School and Department of Pharmaceutics in College of Pharmacy, The University of Michigan, Ann Arbor, MI |
11/1994 –9/1995 | Parke-Davis Graduate Research Fellowship. The Rutgers University, New Brunswick,NJ |
5/1991–11/1994 | NIH Graduate Assistantship, The Rutgers University, New Brunswick, NJ |
9/1986– 8/1990 | Graduate Research fellow in Department of Pharmaceutics, The University of Washington, Seattle, WA |
Honors and Awards
Publications
Book
- Advanced Drug Delivery. John Wiley & Sons, Inc. Co-Edited by AM Mitra, C.H. Lee and K Cheng; 2013
Book Chapter
- Y.W. Chien and C.H. Lee: Drug delivery, Vaginal Route. Encyclopedia of Pharmaceutical Technology, 4th Edition, 1236-1259, 2013 http://www.tandfonline.com/doi/book/10.1081/E-EPT4
- C.H. Lee: Characterization of nitric oxide delivery systems produced by various nanotechnologies in ‘Nitric Oxide: Methods and Protocols’ edited by J Coulter, Human Press. 704: 169-85, 2011
- C.H. Lee and N Giri: Design of Stimulus-sensitive Drug Delivery Systems. in ‘Drug Delivery and Development of Anti-HIV Microbicides’ edited by José das Neves & Bruno Sarmento (Pan Stanford Publishing: ISBN 9789814463560 Cat# N11022). Chapter 10: 377-413, 2014
- C.H. Lee and Yugyung Lee. Chapter 8: Collagen based formulations for wound healing applications. In ‘Wound healing biomaterials Vol 2: functional biomaterials’. Elsevier 2015
Articles
- W Wang, Y Lee, C. H. Lee: Review: Effects of NO on Stem Cell Therapy, JBA-D-15-00045R1, In Print, Biotechnology Advances (2015)
- Y Lee, A Khemka, G Acharya, N Giri and C. H. Lee; A Cascade Computer Model for Microbicide Diffusivity from Mucoadhesive Formulations, BioMedCentral 16:263 (DOI: 10.1186/s12859-015-0684-z) (2015)
- Byeongtaek Oh and Russell B Melchert, C. H. Lee: Bio-inspired Robust Hydrogel for the Delivery of Mesenchymal Stem Cells. DOI: 10.1007/S11095-015-1698-Y, ONLINE APRIL, Pharmaceutical Research (2015)
- Byeongtaek Oh and C. H. Lee: A Smart Mannosylated-reduced Graphene Oxides for Eradication of Macrophage Ablation in Inflammatory Atherosclerosis. Molecular Pharmaceutics (2015)
- Byeongtaek Oh and C. H. Lee: Nanofiber-coated Drug Eluting Stent for the Stabilization of Mast Cells: Pharmaceutical Research, 31: 2463-2478 (2014)
- Gayathri Acharya, Matthew Armstrong, Chris McFall, Rachael W. Quinn, Stephen L. Hilbert, Gabriel L. Converse, Peter B. Toth, Ashley K. Sherman, C.H. Lee, Gary K. Lofland, Richard A. Hopkins: Calcium and Phosphorus Concentrations in Native and Decellularized Semilunar Valve Tissues. Journal of Heart Valve Disease. 23(3) 259-270 (2014)
- Byeongtaek Oh and C. H. Lee: Nanofiber Approach to the Development of Advanced Cardiovascular Stent: Molecular Pharmaceutics, 10 (12), 4432–4442 (2013)
- Byeongtaek Oh and C. H. Lee: Review: Nanofiber for Cardiovascular Tissue Engineering: Expert Opinion on Drug Delivery, 10(11): 1565-1582 (2013) Read More: http://informahealthcare.com/doi/abs/10.1517/17425247.2013.830608
- Yi Liu, W Wang, G Acharya, Y-B Shim, ES Choe, C. H. Lee: Advanced Stent Coating for Drug Delivery and Biocompatibility. J Nanoparticle Research. 15 (10):1962 (2013)
- Y Lee, S. Jana, G Acharya and C. H. Lee: Computational Analysis and Predictive Modeling of Polymorph Descriptors. Chemistry Central Journal. 7:23, 2013 (DOI: 10.1186/1752-153X-7-23)
- W Wang, Y Lee, C. H. Lee: Review: The physiological and computational approach for atherosclerosis treatment. Int J of Cardiology. 167: 1664–1676 (2013) (online 23 October, 2012 (DOI:10.1016/j.ijcard.2012.09.195)
- G Acharya, Y Lee, C. H. Lee: Optimization of Cardiovascular Stent against Restenosis: Factorial Design Based Statistical Analysis of Polymer Coating Conditions. PLoS ONE 7(8): e43100 (2012)
- G Acharya, R Hopkins and C.H. Lee: The Effects of Advanced Polymeric Matrix on Cardiovascular Complications. J Biomedical Material Research. 100A (5): 1151-1159 (2012)
- Y Liu, G Acharya and C. H. Lee: The Effects of DAS on Cardiovascular Complications. J Biomedical Material Research. 99(3):485-92 (2011)
- C. H. Lee: Review: Treatment of Blood Flow Abnormality using Mucosal Delivery of Nitric Oxide. Drug Delivery and Translational Research. 1(3):201–208 (2011)
- JW Yoo, N Giri and C. H. Lee: pH-sensitive Eudragit Nanoparticles for Mucosal Drug Delivery. Int J Pharmaceutics. 403: 262-7 (2011)
- S Cheeti and C. H. Lee: The Involvement of Intracellular Calcium in the Regulation of MCT-Mediated Drug Uptake by HeLa Cells. Molecular Pharmaceutics. 7 (1): 169–176 (2010).
- M Changez, N-G Kang, C H. Lee and J-S Lee. Reversible and pH Sensitive Vesicles from Amphiphilic Homopolymer Poly(2-(4-vinylphenyl)pyridine). Small (Small-Journal), 6(1): 63-68 (2010)
- JW Yoo, ES Choe, SM Ahn and C. H. Lee: Pharmacological activity and protein phosphorylation caused by nitric oxide-releasing microparticles. Biomaterials. 31: 552-558 (2010).
- JW Yoo, J-S Lee and C. H. Lee: Characterization of nitric oxide-releasing microparticles for the mucosal delivery. J Biomedical Material Research. (Published Online: 25 March 2009) 92 (4): 1233-1243 (2010)
- C. H. Lee: Review: Physiological Variables in Heart Valve Substitute Calcification. Expert Opinion on Biological Therapy. 9(8) 1031-1042 (2009)
- JW Yoo, G Acharya and C. H. Lee: In vivo evaluation of vaginal films for mucosal delivery of nitric oxide. Biomaterials. 30:3978-3985 (2009)
- C. H. Lee, V. Moturi and Y. Lee: Thixotropical property in Pharmaceutical formulations. J Cont Rel, 136: 89-98 (2009) Cited by 91 - Related articles (as of February 18, 2015)
- J.G. Park, Q.Ye, E.M. Topp, C.H. Lee, E.Kostoryz, A Mirsa and P Spencer: Dynamic mechanical analysis and esterase degradation of dentin adhesives containing a branched methacrylate, J Biomedical Material Research. 91B: 61-70 (2009)
- M. S. Rahman, M Changez, JW Yoo, C. H. Lee, S Samal, and JS Lee. Synthesis of Amphiphilic Miktoarm Star Copolymers of Poly(n-hexylisocyanate) and Poly(ethylene glycol) through Reaction with the Active Methylene Group. Macromolecules 41 (19):7029-32 (2008)
- K Dharmala, JW Yoo and C. H. Lee: Development of Chitosan-SLN microparticles for chemotherapy: In vitro approach through efflux transporter modulation. J Cont Rel, 131:190-197 (2008)
- H Youn, K Hong, JW Yoo and C. H. Lee. ICAM-1 Expression in vaginal cells as a potential biomarker for inflammatory response. Biomarker 13 (3) 257 - 269 (2008)
- Y Lee, A Khemka, JW Yoo and C. H. Lee: Assessment of Diffusion Coefficient from Mucoadhesive Barrier Devices using artificial neural networks. Int J Pharm 351: 119-126 (2008)
- BK Warrier, R Mallipeddi, JW Yoo and C. H. Lee: Effects of the Surface pH on Interfacial Interactions of Collagen-elastin matrix. Journal Applied Biomaterials and Biomechanics (JABM) 5(3) 140-148 (2007)
- Y Lee, K Dharmala and C. H. Lee: An Intelligent Data Mining Model approach for adverse effects of Hormone Replacement Therapy. Methods of Information in Medicine, 46(1):5-18 (2007)
- S Cheeti, B K. Warrier and C. H. Lee: The Role of Monocarboxylat Transporters in Uptake of Lactic Acid in HeLa Cells. Int J Pharm. 325: 48-54 (2006)
- JW Yoo and C. H. Lee: Drug Delivery Systems for Hormone Therapy” J Cont Rel, 112: 1-14 (2006)
- JW Yoo, K Dharmala and C. H. Lee: The physicodynamic properties of mucoadheisve polymeric films developed as female controlled drug delivery system. Int J Pharm. 309 (1-2) 139-149 (2006)
- C.H. Lee, A. Singla, and Y. Lee; Biomedical application of Collagen. Int J Pharmaceutics. 221 (1-2), 1-22 (2001) (-Cited by 1155 - Related articles as of September 18, 2015)