Mitra Ashim K, PhD
Mitra Ashim K, PhD
Professor and Chairman

Division of Pharmaceutical Sciences
University of Missouri
USA

Education

  • B.S. in Pharmacy, 1974, Jadavpur University, Calcutta, India Pharmaceutical Sciences
  • M.S. in Pharmaceutics, 1976, Jadavpur University, Calcutta, India
  • M.S. in Pharmaceutical Chemistry, 1980, University of Kansas
  • Ph.D. in Pharmaceutical Chemistry, 1983, University of Kansas

 

Profile

Dr. Mitra received his Ph.D. in Pharmaceutical Chemistry in 1983 from the University of Kansas. Upon graduation he was employed as an Assistant Professor of Biopharmaceutics at the University of Nebraska Medical Center for one year. In 1984, he joined Purdue University as an Assistant Professor and later became an Associate Professor of Physical Pharmacy from 1989-1994. That year in 1994, he was accepted as Professor and Chairman of UMKC School of Pharmacy, Division of Pharmaceutical Sciences. He received the University of Missouri Curators’ Professor of Pharmacy Award in 2002. Within two years, he was appointed Co-Director, Kansas City Vision Research Center, UMKC School of Medicine and UMKC Vice Provost for Interdisciplinary Research.

 

Research Interest

His current research interests are focused on two main areas: delivery and targeting of antiviral agents and development of noninvasive delivery systems for peptide and protein drugs.

Professional Activities:

2004 – Present Vice Provost for Interdisciplinary Research University of Missouri- Kansas City.
  Co-Director, Vision Research Center-School of Medicine University of Missouri-Kansas City
2002– Present Professor of Pharmacy University of Missouri Curators’
1994 – Present Professor and Chairman, Division of Pharmaceutical Sciences School of Pharmacy University of Missouri-Kansas City
1989 – 1994 Associate Professor of Physical Pharmacy, Department of Industrial and Physical Pharmacy Purdue University
1984 – 1989 Assistant Professor of Physical Pharmacy, Department of Industrial and Physical Pharmacy, School of Pharmacy and Pharmacal Sciences Purdue University
1983 – 1984 Assistant Professor of Biopharmaceutics, Department of Pharmaceutics, College of Pharmacy University of Nebraska Medical Center
1979 – 1983 Research Assistant Department  of Pharmaceutical Chemistry University of Kansas
1978 – 1979 Teaching Assistant, Pharmaceutical Chemistry Department University of Kansas

 

Honors and Awards

Publications

Books

  1. Mitra, AK, Kwatra D, Vadlapudi AD., (Editors) Drug Delivery, (18 Chapters) First Edition, Jones & Bartlett Learning, (Publilsher) Burlington, MA, ISBN-13: 978-1-284-02568-2, (includes online access code) August 2014.
  2. Cholkar K, Vadlapudi AD, Hoang MT, Mitra AK “Compositions, Formulations, Pharmacology, Pharmacokinetics, and Toxicity of Topical, Periocular, and Intravitreal Ophthalmic Drugs,Brian C. Gilger (Editor), Ocular Pharmacology and Toxicology Methods in Pharmacology and Toxicology, Humana Press/Springer Protocols (Publisher) New York, Chapter 6, pages 91-118, August 2014.
  3. Mitra AK, Lee, CH, Cheng K., (Editors) Advanced Drug Delivery, Wiley & Sons (Publisher), New York, NY, B00GO3VT3E, 1 Edition, 24 Chapters (550 pgs) August 26, 2013.
  4. Mitra AK, (Editor) Ocular Transporters and Receptors: Their Role in Drug Delivery, Woodhead Publishing Series in Biomedicine (Publisher), Cambridge, UK, ISBN 1907568867, 1 Edition,  7 Chapters (276 pgs) October 18, 2013.
  5. E-Book: Mitra AK. (editor), Treatise on Ocular Drug Delivery, [Kindle Edition],Bentham Science Publishers, Saif Zone, Sharjah, United Arab Emirates, B00EHHLDTY, 10 Chapters, (335 pgs) June 26, 2013.
  6. E-Book: Mitra AK. (editor), Advances in Ocular Drug Delivery, Research Signpost/Transworld Research Network (Publisher), Trivandrum, Kerala, India, 978-81-308-0490-3, 5 Chapters, (134 pgs) 2012.
  7. Mitra AK. (editor)  Ophthalmic Drug Delivery Systems" Second Edition, Revised and Expanded, (Drugs and the Pharmaceutical Sciences) Marcel Dekker, New York, N.Y., Vol. 130, 21 Chapters, March 25, 2003.

Book Chapters

  1. Vadlapudi AD, Kwatra D, Mitra, AK.,“Drug Delivery: An Evolving Concept”, Mitra, AK, Kwatra D, Vadlapudi AD (Editors) Drug Delivery, (18 Chapters) First Edition, Jones & Bartlett Learning, (Publisher) Burlington, MA, ISBN-13: 978-1-284-02568-2, (includes online access code), Chapter 1, pages, 1-7, August 2014.
  2. Shah SJ, Vadlapatla RK, Mitra AK., “Barriers to Drug Delivery”, Mitra, AK, Kwatra D, Vadlapudi AD (Editors) Drug Delivery, (18 Chapters) First Edition, Jones & Bartlett Learning, (Publisher) Burlington, MA, ISBN-13: 978-1-284-02568-2, (includes online access code), Chapter 2, pages 8-29, August 2014.
  3. Kwatra D, Khurana V,  Mitra AK., “In Vitro Models in Drug Discovery and Delivery”, Mitra, AK, Kwatra D, Vadlapudi AD (Editors) Drug Delivery, (18 Chapters) First Edition, Jones & Bartlett Learning, (Publisher) Burlington, MA, ISBN-13: 978-1-284-02568-2, (includes online access code), Chapter 3, pages 30-49, August 2014.
  4. Vadlapudi AD, Choklar K, Dasari SR, Mitra AK., “Ocular Drug Delivery”, Mitra, AK, Kwatra D, Vadlapudi AD (Editors) Drug Delivery, (18 Chapters) First Edition, Jones & Bartlett Learning, (Publisher) Burlington, MA, ISBN-13: 978-1-284-02568-2, (includes online access code), Chapter 10, pages 220-263, August 2014
  5. Earla R, Mitra, AK.,“Drug Metabolomics and Proteomics Analysis in Drug Delivery and Discovery”, Mitra, AK, Kwatra D, Vadlapudi AD (Editors) Drug Delivery, (18 Chapters) First Edition, Jones & Bartlett Learning, (Publisher) Burlington, MA, ISBN-13: 978-1-284-02568-2, (includes online access code), Chapter 18, pages, 430-448, August 2014.
  6. Cholkar K, Vadlapudi AD, Trinh HM, Mitra AK., “Compositions, Formulation, Pharmacology, Pharmacokinetics, and Toxicity of Topical, Periocular, and Intravitreal Ophthalmic Drugs”, Brian C. Gilger (Editor) Ocular Pharmacology and Toxicology, (Methods in Pharmacology and Toxiciology), Humana Press (Publisher), New York City, NY, DOI 10. 1007/7653_2013_10, Chapter 6, pages 91-118, August 2013.
  7. Khurana V, Pal D, Minocha M, Mitra AK., “The Role of Transporters and Efflux Systems in Drug Delivery”, Mitra AK, Lee, CH, Cheng K., (Editors) Advanced Drug Delivery, Wiley & Sons (Publisher), New York, NY, B00GO3VT3E, 1 Edition, Chapter 3, pages 47-74, August 2013.
  8. Vadlapatla RK, Shah S, Vadlapudi AD, Mitra AK., “Prodrug and Bioconjugation”, Mitra AK, Lee, CH, Cheng K., (Editors) Advanced Drug Delivery, Wiley & Sons (Publisher), New York, NY, B00GO3VT3E, 1 Edition, Chapter 6, pages 123-140, August 2013.
  9. Gokulgandhi MR, Patel A, Cholkar K, Barot M, Mitra AK., “Nanoscale Drug Delivery Systems”, Mitra AK, Lee, CH, Cheng K., (Editors) Advanced Drug Delivery, Wiley & Sons (Publisher), New York, NY, B00GO3VT3E, 1 Edition, Chapter 7, pages 141-156, August 2013].
  10. Vadlapudi AD, Patel A, Vadlapatla RK, Paturi D, Mitra AK., “Implants”, Mitra AK, Lee, CH, Cheng K., (Editors) Advanced Drug Delivery, Wiley & Sons (Publisher), New York, NY, B00GO3VT3E, 1 Edition, Chapter 9, pages 183-200, August 2013.
  11. Barot M, Gokulgandhi MR, Ray A, Mitra AK., “Nanofiber”, Mitra AK, Lee, CH, Cheng K., (Editors) Advanced Drug Delivery, Wiley & Sons (Publisher), New York, NY, B00GO3VT3E, 1 Edition, Chapter 11, pages 219-230, August 2013.
  12. Patel M, Barot M, Renukuntla J, Mitra AK., “Protein/Peptide Drug Delivery”, Mitra AK, Lee, CH, Cheng K., (Editors) Advanced Drug Delivery, Wiley & Sons (Publisher), New York, NY, B00GO3VT3E, 1 Edition, Chapter 13, pages 241-256, August 2013.
  13. Khurana V, Kwatra D, Agrahari V, Mitra AK., “Recent Advances in Ocular Drug Delivery”, Mitra AK, Lee, CH, Cheng K., (Editors) Advanced Drug Delivery, Wiley & Sons (Publisher), New York, NY, B00GO3VT3E, 1 Edition, Chapter 19, pages 365-380, August 2013.
  14. Mandava N, Patel M, Mitra AK., “Advanced Drug Delivery to the Brain”, Mitra AK, Lee, CH, Cheng K., (Editors) Advanced Drug Delivery, Wiley & Sons (Publisher), New York, NY, B00GO3VT3E, 1 Edition, Chapter 21, pages 405-422, August 2013.
  15. Cholkar K, Dasari SR, Pal D, Mitra AK., “Eye: Anatomy, Physiology and Barriers to Drug Delivery”, Mitra AK, (Editor) Ocular Transporters and Receptors: Their Role in Drug Delivery, Woodhead Publishing Ltd. (Publisher), Cambridge, UK, ISBN 1907568867, 1 Edition, Chapter 1, pages 1-36, October 18, 2013.
  16. Pal D, Vadlapatla RK, Vadlapudi AD, Mitra AK., “Biology of Ocular Transporters and Receptors”, Mitra AK, (Editor) Ocular Transporters and Receptors: Their Role in Drug Delivery, Woodhead Publishing Ltd. (Publisher), Cambridge, UK, ISBN ISBN 1907568867, 1 Edition, Chapter 2, pages 37-84, October 18, 2013.
  17. Ray A, Cholkar K, Wang Z, Mitra AK., “Characterization of Ocular Transporters”, Mitra AK, (Editor) Ocular Transporters and Receptors: Their Role in Drug Delivery, Woodhead Publishing Ltd. (Publisher), Cambridge, UK, ISBN ISBN 1907568867, 1 Edition, Chapter 3, pages 85-114, October 18, 2013.
  18. Cholkar K, Ray A, Agrahari V, Pal D, Mitra AK., “Transporters and Receptors in the Anterior Segment of the Eye”, Mitra AK, (Editor) Ocular Transporters and Receptors: Their Role in Drug Delivery, Woodhead Publishing Ltd. (Publisher), Cambridge, UK, ISBN 1907568867, 1 Edition, Chapter 4, pages 115-168, October 18, 2013.
  19. Patel A, Gokulgandhi MR, Khurana V, Mitra AK., “Transporters and Receptors in the Posterior Segment of the Eye”, Mitra AK, (Editor) Ocular Transporters and Receptors: Their Role in Drug Delivery, Woodhead Publishing Ltd. (Publisher), Cambridge, UK, ISBN 1907568867, 1 Edition, Chapter 5, pages 169-206, October 18, 2013.
  20. Tamboli V, Shah S, Mitra AK., “Transporters in Drug Discovery and Delivery: A New Paradigm in Ocular Drug Design”, Mitra AK, (Editor) Ocular Transporters and Receptors: Their Role in Drug Delivery, Woodhead Publishing Ltd. (Publisher), Cambridge, UK, ISBN 1907568867, 1 Edition, Chapter 6, pages 207-228, October 18, 2013.
  21. Barot M, Patel M, Kwatra D, Mitra AK., “Transporter-Metabolism Interplay in the Eye”, Mitra AK, (Editor) Ocular Transporters and Receptors: Their Role in Drug Delivery, Woodhead Publishing Ltd. (Publisher), Cambridge, UK, ISBN 1907568867, 1 Edition, Chapter 7, pages 229-248, October 18, 2013.
  22. BodduSHS, Menees AL, Ray A, Mitra AK, “A Brief Overview of Ocular Anatomy and Physiology”,E-Book: Mitra AK. (Editor), Treatise on Ocular Drug Delivery, Bentham Science Publishers, Saif Zone, Sharjah, United Arab Emirates, B00EHHLDTY, Chapter 1, pages 3-19, June 26, 2013.
  23. Kwatra D, Vadlapatla RK, Khurana V, Pal D, Mitra AK, “Routes of Drug Delivery- Conventional vs. Novel Routes”,E-Book: Mitra AK. (Editor), Treatise on Ocular Drug Delivery, Bentham Science Publishers, Saif Zone, Sharjah, United Arab Emirates, B00EHHLDTY, Chapter 2, pages 20-41, June 26, 2013.
  24. Renukuntla J, Shah S, Vadlapudi AD, Patel M, Mitra AK, “Drug Delivery to Anterior Segment of the Eye”,E-Book: Mitra AK. (Editor), Treatise on Ocular Drug Delivery, Bentham Science Publishers, Saif Zone, Sharjah, United Arab Emirates, B00EHHLDTY, Chapter 3, pages 42-67, June 26, 2013.
  25. Gaudana RJ, Barot M, Patel A, Khurana V, Mitra AK, “Barriers for Posterior Segment Ocular Drug Delivery”, E-Book: Mitra AK. (Editor), Treatise on Ocular Drug Delivery, Bentham Science Publishers, Saif Zone, Sharjah, United Arab Emirates, B00EHHLDTY, Chapter 4, pages 68-95, June 26, 2013.
  26. Tamboli V, Patel S, Mishra GP, Mitra AK, “Biodegradable Polymers for Ophthalmic Applications”, E-Book: Mitra AK. (Editor), Treatise on Ocular Drug Delivery, Bentham Science Publishers, Saif Zone, Sharjah, United Arab Emirates, B00EHHLDTY, Chapter 5, pages 96-113, June 26, 2013.
  27. Karla PK, Boddu SHS, Patel A, Ako-Adouno AM, Mitra AK, “Novel Strategies to Enhance Ocular Bioavailability”, E-Book: Mitra AK. (Editor), Treatise on Ocular Drug Delivery, Bentham Science Publishers, Saif Zone, Sharjah, United Arab Emirates, B00EHHLDTY, Chapter 7, pages 140-160, June 26, 2013.
  28. Rittenhouse KD, Atluri H, Boddu SHS, Mitra AK, “Microdialysis-Utility in Establishing PK/PD Relationships in Ophthalmology”,E-Book: Mitra AK. (Editor), Treatise on Ocular Drug Delivery, Bentham Science Publishers, Saif Zone, Sharjah, United Arab Emirates, B00EHHLDTY, Chapter 8, pages 161-202, June 26, 2013.
  29. Yang X, Patel A, Vadlapudi AD, Mitra AK, “Application of Nanotechnology in Ocular Drug Delivery”, E-Book: Mitra AK. (Editor), Treatise on Ocular Drug Delivery, Bentham Science Publishers, Saif Zone, Sharjah, United Arab Emirates, B00EHHLDTY, Chapter 10, pages 253-284, June 26, 2013.
  30. Patel M, Mandava N, Mitra AK. “Microdialysis in Ocular Drug Development”, Muller, Markus (Ed.), Microdialysis in Drug Development, AAPS Advances in the Pharmaceutical Sciences (Book 4), “Springer, New York, NY, Vol. 4, Pt 2, 197-222, September 11, 2012.
  31. Tamboli V, Mishra GP,Mitra AK.“Biodegradable polymers for ocular drug delivery”, in Mitra AK edits, E-Book: Advances in Ocular Drug Delivery, Research Singpost/Transworld Research Network (Publisher), Trivandrum, Kerala, India, Chapter 3, pp 65-86, 2012.
  32. Paturi D; Patel M; Mitra R; Mitra AK, “Nasal and Pulmonary Delivery of Macromolecules to Treat Respiratory and Nonrespiratory Diseases”, Pulmonary Nanomedicine: Diagnostics, Imaging, and Therapeutics, Neeraj Vij, Editor, Pan Stanford Publishing Pte. Ltd, Chapter 3, pp. 45-102, 2012.
  33. Vadlapudi AD, Vadlapatla RK, Johnston TP, Mitra AK. “Peptides and proteins: Buccal absorption” in James Swarbrick Eds., Encyclopedia of Pharmaceuticals Sciences and Technology, 4th Edition, Informa Healthcare, Marcel Dekker, Inc. New York 2011.
  34. Vaishya DR, Ananthula HK, and Mitra AK, “Microdialysis for Vitreal Pharmacokinetics“ in Kompella UB and Edelhauser HF Eds. Drug Product Development for the Back of the Eye, Springer Science + Business Media, New York, USA, Chapter 2, Vol. 2, 21-45, 2011.
  35. Karla PK; Boddu S.H.S.; Dasari C; Mitra AK. “Outward-Directed Transport”, Adler's Physiology of the Eye (11th Edition), Publisher: (Saunders) Elsevier, New York, edited Leonard A. Levin, M.D, Siv F.E. Nilsson, Ph.D., James Ver Hoeve, MD, Samuel M. Wu, Ph.D., Chapter 17, 385-393, 2011.
  36. Kwatra D; Vaishya R, Gaudana R, Jwala J; Mitra AK, “Ocular delivery using prodrugs”, Prodrug and Targeted Delivery; Publisher Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany, edited by Dr. Jarkko Rautio, Vol 47, Chapter 8, 181-205, 2010.
  37. Talluri RS; Hariharan S; Karla PK; Mitra AK, “Drug Delivery to Cornea and Conjunctiva: Esterase- and Protease-Directed Prodrug Design,” In: Darlene A. Dartt, editor, Encyclopedia of the Eye, Elsevier, Oxford: Academic Press; New York, NY, 2:42-53, 2010.
  38. Mishra GP; Gaudana R; Tamboli VM; Mitra AK, “Recent Advances in Ocular Drug Delivery: Role of Transporters, Receptors, and Nanocarriers”. Targeted Delivery of Small and Macromolecular Drugs, Publisher, Taylor & Francis Group,Boca Raton, Fl, edited by Ajit S. Narang & Dr Ram I. Mahato. Pages, 421-453 2010.
  39. Ananthula HK, Vaishya RD; Barot M; Mitra AK, “Bioavailability in Ocular Pharmacology”, Duane's Foundations of Clinical Ophthalmology,Lippincott Williams & Wilkins (eBOOK Volume 3, 2009.
  40. Boddu, S HS; Jwala J; Janoria KG Pal D; Mitra AK. “Development of Steroid-Nanoparticles for the Treatment of Macular Edema”, The Journal of Interdisciplinary Research (JIDR) Vol 2, No 1, Megan Cornell (Ed), KCMO, 81-99, 2008.
  41. Karla PK; Kwatra D; Gaudana R; Mitra AK. “Nasal Drug Delivery”, Modified-Release Drug Delivery Technology, 2nd Ed, Vol 2, Michael J. Rathbone, Jonathan Hadgraft, Michael s. Roberts and Majella E. Lane (Eds.), Informa Healthcare, 427-450, 2008.
  42. Talluri S; Mishra GP; Mitra AK. Ophthalmic infections and therapeutic strategies, Advanced Drug Formulation Design to Optimize Therapeutic Outcomes, Skinner M, Williams III RO, Taft DR, McConville JT (Eds.), CRC Press, Inc., Florida, 143-170, 2008.
  43. Gunda S; Hariharan S; Mandava N; Mitra AK. “Barriers in Ocular Drug Delivery, in: Ocular Transporters, Ophthalmic Diseases and Drug Delivery.” Tombran-Tink J, Barnstable CJ (Eds.), Humana Press, Inc., New Jersey, 399-414, 2008.
  44. Budda B; Kansara V; Mitra AK. Mechanisms of Drug Entry into Nucleus, Drug Delivery Research Advances, Boris O. Mashkevich (Ed), Nova Science Publishers, Inc., Waltham, MA, Chapter 5, 153-180, 2007.
  45. Kansara V; Budda B; Mitra AK. Advancements in Ocular Drug Delivery, Drug Delivery Research Advances, Boris O. Mashkevich (Ed), Nova Science Publishers, Inc., Waltham, MA, Chapter 1, 1-37, 2007.
  46. Mitra AK; Anand BS; Duvvuri S.  “Drug Delivery to the Eye”, The Biology of the Eye - Advances in Organ Biology, Edited by Jorge Fischbarg, Elsevier, Inc., Amsterdam, The Netherlands, Chapter 12, Vol. 10, 307-351, 2006. 
  47. Alur H, Jain B, Dey S, Johnston TJ, Jasti B, Mitra AK, “Physicochemical Factors Affecting Biological Activity”, Theory and Practice of Contemporary Pharmaceutics, Edited by Tapash K. Ghosh and Bhaskara R. Jasti, CRC Press LLC, Washington, DC, Chapter 4, 83-136, 2005. 
  48. Atluri H, Tirucherai GS, Dias CS, Patel J, Mitra AK, “Ocular, Nasal, Pulmonary, and Otic Routes of Drug Delivery”, Theory and Practice of Contemporary Pharmaceutics, Edited by Tapash K. Ghosh and Bhaskara R. Jasti, CRC Press LLC, Washington, DC, Chapter 16, 479-524, 2005. 
  49. Sreeraj M., Mitra AK., Hughes PM.  “Overview of Ocular Drug Delivery”, Ophthalmic Drug Delivery Systems, Second Edition, Revised and Expanded, Marcel Dekker, New York, N.Y., Vol. 130, 1-12, 2003.
  50. Sreeraj M., Mitra AK.  “Posterior Segment Microdialysis”, Ophthalmic Drug Delivery Systems, Second Edition, Revised and Expanded, Marcel Dekker, New York, N.Y., Vol. 130, 251-279, 2003.
  51. Johnston TP, Dias CS, Mitra AK, Alur H.  “Mucoadhesive Polymers in Ophthalmic Drug Delivery”, Ophthalmic Drug Delivery Systems, Second Edition, Revised and Expanded, Marcel Dekker, New York, N.Y., Vol. 130, 409-435, 2003.
  52. Dey S., Mitra AK., Krishnamoorthy R.  “Ocular Delivery and Therapeutics of Proteins and Peptides”, Ophthalmic Drug Delivery Systems, Second Edition, Revised and Expanded, Marcel Dekker, New York, N.Y., Vol. 130, 493-514, 2003.
  53. Zheng, X, Marquart ME, Mitra AK, Hill JM.  Unique Ocular Drug Delivery Systems, in Textbook ofOphthalmology, First Edition, (Eds. Agarwal S, Agrawal Athiya, Apple DJ, Buratto L, Alio JL, Pandey SK, Agrawal Amar), Jaypee Brothers Medical Publishers (P) Ltd., New Delhi, India, 3(L-231):2076-2089, 2002.
  54. Johnston, T.P., Mitra AK.  “Polysaccharide-Based Mucoadhesive Buccal Tablets” in Modified-Release Drug Delivery Technology, Ian Kellaway and Michael Rathbone, Editors, Marcel Dekker, NY, Chapter 33, 401-418, 2002. 
  55. Alur, H.H., Johnston, T.P., Mitra AK.  “Peptides and Proteins:  Buccal Absorption” in Encyclopedia of Pharmaceutical Technology, First Edition, (Eds. James Swarbrick and James C. Boylan), Marcel Dekker, Inc., NY, 20:3, 193-218, 2002.
  56. Zheng, X, Marquart ME, Mitra AK, Hill JM.  Unique Ocular Drug Delivery Systems, in Textbook ofOphthalmology, First Edition, (Eds. Agarwal S, Agrawal Athiya, Apple DJ, Buratto L, Alio JL, Pandey SK, Agrawal Amar), Jaypee Brothers Medical Publishers (P) Ltd., New Delhi, India, 3(L-231):2076-2089, 2002.
  57. Johnston, T.P., Mitra AK.  “Polysaccharide-Based Mucoadhesive Buccal Tablets” in Modified-Release Drug Delivery Technology, Ian Kellaway and Michael Rathbone, Editors, Marcel Dekker, NY, Chapter 33, 401-418, 2002. 
  58. Alur, H.H., Johnston, T.P., Mitra AK.  “Peptides and Proteins:  Buccal Absorption” in Encyclopedia of Pharmaceutical Technology, First Edition, (Eds. James Swarbrick and James C. Boylan), Marcel Dekker, Inc., NY, 20:3, 193-218, 2002.
  59. Krishnamoorthy, R., Duggirala, S.M., Mitra AK.  “Prodrug and Analogue Design in Nasal Drug Delivery” in Advanced Drug Delivery Reviews, A.K. Mitra, and A.N. Harris, Editors, Elservier Publishers, 29(1,2):135-146, 1998.
  60. Krishnamoorthy, R., Mitra AK.  Peptide Metabolism by Gastric, Pancreatic and Lysosomal Proteinases in "Peptide-Based Drug Design:  Controlling Transport and Metabolism," M. Taylor and G. Amidon eds., American Chemical Society, Washington, DC pp. 49-68, 1995.
  61. Li Y; Mitra AK. Effects of Formulation Variables on the Pulmonary Delivery of Insulin, Drug Dev & Industrial Pharm, Chapter-Communications, Purdue University, Marcel Dekker, Inc., New York, NY., 20(12):2017-2024, 1994.
  62. Hughes, P.M., Mitra AK.  Overview of Ocular Drug Delivery and Iatrogenic Ocular Cytopathologies in Ophthalmic Drug Delivery Systems, editor Mitra AK. Marcel Dekker, New York, N.Y., 58, 1-27, 1993.
  63. Krishnamoorthy, R., Mitra AK.Ocular Drug Delivery in "Ophthalmic Drug Delivery Systems," editor Mitra AK. Marcel Dekker, New York, N.Y., 58, 199-221, 1993.
  64. Krishnamoorthy, R., Mitra AK.Ocular Delivery of Peptides and Proteins in "Ophthalmic Drug Delivery Systems," editor Mitra AK. Marcel Dekker, New York, N.Y., 58, 455-470, 1993.
  65. Mitra AK. Ghosh, M.K.  Drug-Immunoglobulin Conjugates as Targeted Therapeutic Systems in "Targeted Diagnosis and Therapy," (Tyle, P. ed.) Marcel Dekker, New York, N.Y., Ch. 7, 141-187, 1990.
  66. Mitra AK.  “Ophthalmic Drug Delivery Devices” in Drug Delivery Devices, (Praveen Tyle, Ed) Marcel Dekker, New York, N.Y., Ch. 15; 455-470, 1988.

Refereed Articles

  1. Ray A, Mandal A, Joseph M, Mitra AK., Recent patents on nanoparticles and nanoformulations for cancer therapy, Recent Pat Drug Deliv Formul. 2015 Aug 18. [Epub ahead of print].
  2. Ray A, Mandal A, Mitra AK., Recent patents in pulmonary delivery of macromolecules, Recent Pat Drug Deliv Formul. 2015 Jul 29. [Epub ahead of print].
  3. Yang X, Trinh HM, Agrahari V, Sheng Y, Pal D, Mitra AK., Nanoparticle-Based Topical Ophthalmic Gel Formulation for Sustained Release of Hydrocortisone Butyrate, J. AAPS PharmSciTech, 10.1208/s12249-015-0354-5, 2015, [IN PRESS].
  4. Cholkar K, Trinh HM,Vadlapudi AD, Wang Z, Pal D, Mitra AK., Interaction studies of RX-10045 (Resolvin E1 Analog) with Efflux Transporters, J. of Pharmacol and Therap, Feb 2015[IN PRESS].
  5. Vadlapatla RK, Vadlapudi AD, Pal D, Mitra AK., Role of Membrane Transporters and Metabolizing Enzymes in Ocular Drug Delivery, Curr Drug Met 2014, 15, 000-000 [IN PRESS].
  6. Vaishya R, Khurana V, Patel S, Mitra AK., Expert Opinion on Long-term Controlled Protein Delivery, Exp Opin on Drug Disc., Doi:10.1517/17425247.2015.961420, 2014.[IN PRESS].
  7. Vaishya R, Mitra AK. “Future of sustained protein delivery." Therapeutic Delivery. [IN PRESS].
  8. Patel S, Vaishya R, Mishra GP, Tamboli V, Pal D, Mitra AK., Tailor-made Pentablock Copolymer Based Formlulation for Sustained Ocular Delivery of Protein Therapeutics, J Drug Delivery, April 2014 [IN PRESS].
  9. Karmel M, Cantor LB, Iwach AG, Mitra AK, Novack GD., “Glaucoma Novel Approaches to Drug Delivery”, (Publisher) American Academy of Ophthalmology, Eyenet, Dec 2013, [IN PRESS].
  10. Vadlapudi AD, Mitra AK., Sustained Delivery of Biologics to Back of the Eye, Journal of Biotechnology and Biomaterials, August 2013 [IN PRESS].
  11. Kwatra D, Mitra AK., Drug Delivery in Ocular Diseases: Barriers and Strategies, World J of Pharmacol, 2013 [IN PRESS].
  12. Renukuntla J, Shah S, Boddu SHS, Vadlapudi AD, Vadlapatla RK, Pal D, Mitra AK., Functional characterization and expression of folate receptor-α in T47D human breast cancer cells, Drug Dev & Therap., 6(2):52-61, July 2015.
  13. Vaishya RD, Mandal A, Gokulgandhi M, Patel S, Mitra AK., Reversible Hydrophobic Ion-Paring Complex Strategy to Minimize Acylationof Octreotide during Long-Term Delivery from PLGA Microparticles, Intl J Pharmaceu., 489:237-245, 2015.
  14. Cholkar K, Gilger BC, Mitra AK., Topical, Aqueous, Clear Cyclosporine Formulation Design For Anterior and Posterior Ocular Delivery" Translational Vision Science & Technology TVST, 4(3):, March 2015.
  15. Yang X, Sheng Y, Ray A, Shah SJ, Trinh HM, Pal D, Mitra AK., The Uptake and Bioconversion of Stereoisomeric Dipeptide Prodrugs of Ganciclovir-Loaded Nanoparticles in Corneal Cells, Drug Del, 16:1-9, 2015.
  16. Sheng Y, Yang X, Pal D, Mitra AK., Prodrug approach to improve absorption of prednisolone, Intl J Pharmaceu, 487:242-249, 2015.
  17. Cholkar K, Trinh HM, Pal D, Mitra AK., Discovery of Novel Inhibitors for the Treatment of Glaucoma. Exp Opin on Drug Disc., 10(3):1-21, 2015.
  18. Yang X, Shah S, Wang Z, Pal D, Mitra A., Nanoparticle-based topical ophthalmic formulation for sustained release of stereoisomeric dipeptide prodrugs of ganciclovir, Drug Del, 7:1-11, 2015.
  19. Cholkar K, Gunda S, Earla R, Pal D, Mitra AK. “Nanomicellar Topical Aqueous Drop Formulation of Rapamycin for Back of the Eye Delivery”, AAPS PharSciTech, DOI: 10.1208/s12249-014-0244-2, 2014.     
  20. Cholkar K, Trinh HM, Vadlapudi AD, Mitra AK., Synthesis and Characterization of Ganciclovir Long Chain Lipid Prodrugs, MedCrave Advances in Ophthalmology & Visual System, Adv Ophthalmol Vis Syst. Aug 27;1(2):1-14, 2014.
  21. Patel A, Patel M, Yang X, Mitra AK., Recent Advances in Protein and Peptide Drug Delivery: A Special Emphasis on Polymeric Nanoparticles, Protein &Pept Lett, Aug 7, 21(11), 1102-1120, 2014.
  22. Khurana V, Kwatra D, Pal D, Mitra AK., Molecular Expression and Functional Activity of Vitamin C. Specific Transport System (SVCT2) in Human Breast Cancer Cells, Int’l J. Pharmaceu, Oct 20, 474(1-2):14-24, 2014.
  23. Vaishya RD, Gokulgandhi M, Patel S, Minocha M, Mitra AK., Novel Dexamethasone-Loaded Nanomicelles for the Intermediate and Posterior Segment Uveitis, AAPS PharmSciTech., June 4, 15(5):1238-1251, 2014.
  24. Khurana V, Minocha M, Pal D, Mitra AK., Inhibition of OATP-1B1 and OATP-1B3 by tyrosine kinase inhibitors, Drug Metabol Drug Interact.,Dec 1, 29(4):249-259, 2014.
  25. Patel A, Gaudana R, Mitra AK., A novel approach for antibody nanocarriers development through hydrophobic ion-pairing complexation, J Microencapsul, Apr 3, 31(6):542-550, 2014.
  26. Vaishya RD, Khurana V, Patel S, Mitra AK., Controlled Ocular Drug Delivery with Nanomicelles, Wiley Advanced Review, Sept-Oct, 6(5):422-437, 2014.
  27. Khurana V, Patel SP, Agrahari V, Pal D, Mitra AK., Novel Pentablock Copolymer Based Nanoparticles Containing Pazopanib: A Potential Therapy for Ocular Neovascularization, Recent Patents on Nanomedicine, July 26, 4(1):57-68, 2014.
  28. Cholkar K, Hariharan S, Gunda S, Mitra AK, Optimization of Dexamethasone Mixed Nanomicellar Formulation, AAPS PharmSciTech, Jul 1, 15(6):1454-1467, 2014.
  29. Gunda S, Earla R, Cholkar K, Mitra AK., Pharmacokinetic studies and LC-MS/MS method development of ganciclovir and dipeptide monoester prodrugs in sprague dawley rats, Eur J Drug Meta Pharmaco, Springer International Publishing Switzerland,10.1007/s13318-014-0200-22014 [Epub ahead of print].
  30. Khurana V, Minocha M, Pal D, Mitra AK, Role of OATP-1B1 and/or OATP-1B3 in HepaticDisposition of Tyrosine Kinase Inhibitors, Drug Metabol Drug Interac, Mar 18, 29(3):179-190, 2014.
  31. Patel A, Gaudana R, Mitra AK., "A novel approach to antibody nanocarriers development through hydrophobic ionpairing complexation" Journal of Microencapsulation, Apr 3, 31(6):542-550, 2014.
  32. Yang X, Patel S, Sheng Y, Pal D, Mitra AK. Statistical Design for Formulation Optimization of Hydrocortisone Butyrate-loaded PLGA Nanoparticles. AAPS PharmSciTech., Feb 7, 15(3):569-587, 2014.
  33. Vadlapatla RK, Pal D, Vadlapudi AD, Mitra AK, Ritonavir: A Powerful Boosting Agent for Overcoming Drug Resistance in Cancer Chemotherapy,J Cancer Science & Therapy, Cancer Sci Ther, 6(11):446-454, 2014.
  34. Gilger BC, Mandall A, Shah S, Mitra AK., Episcleral, Intrascleral, and Suprachoroidal Routes of Ocular Drug Delivery - Recent Research Advances and Patents, Recent Pat Drug Deliv Formul 8(2):81-91, 2014.
  35. Khurana V, Vadlapudi AD, Vadlapatla RK, Pal D, Mitra AK., Functional Characterization and Molecular Identification of Vitamin C Transporter (SVCY2) in Human Corneal Epithelial (HCEC) and Retinal Pigment Epithelial (D407) Cells, Curr Eye Res, Early Online, Informa Healthcare USA, Inc. 1-13, 2014.
  36. Patel M, Mandava N, Gokulgandhi M, Pal D, Mitra AK., Amino Acid Prodrugs: An Approach to Improve the Absorption of HIV-1 Protease Inhibitor, Lopinavir, Pharmaceuticals, doi:10.3390/ ph7040433, 7:433-452, 2014
  37. Kwatra D, Vadlapudi AD, Vadlapatla RK, Khurana V, Pal D, Mitra AK., Binary and Ternary Combinations of Anti-HIV Protease Inhibitors: Effect on Gene Expression and Functional Activity of CYP3A4 and Efflux Transporters. Drug Metabol Drug Interact, 8:1-10, 2014.
  38. Patel Aǂ, Cholkar Kǂ, Mitra AK., Recent Developments in Protein and PeptideParenteral Delivery Approaches, Therp Delivery 5(3):337-365, 2014.ǂFirst two authors contributed equally to the preparation of manuscript.
  39. Vadlapatla RK, Vadlapudi AD, Pal D, Mukherji M, Mitra AK. Ritonavir Inhibits HIF-1α Mediated VEGF Expression in Retinal Pigment Epithelial Cells in Vitro, Nature Eye (Lond), 1:93-101, 2014.
  40. Vadlapatla RK, Patel M, Paturi DK, Pal D, Mitra AK. Clinically relevant drug-drug interactions between antiretrovirals and antifungals. Expert Opin Drug Metab Toxicol. 10(4):561-580, 2014.
  41. Patel M, Mandava NK, Pal D, Mitra AK. Amino Acid Prodrug of Quinidine: An Approach to Circumvent P-glycoprotein Mediated Cellular Efflux, Int J Pharm. 464(1-2):196-204, 2014.
  42. Barot M, Gokulgandhi MR; Pal D, Mitra AK., In vitro moxiflxacin drug interation with chemotherapeutics: Implications for retinoblastoma management, Exp Eye Res 118:61-71, 2014.
  43. Vadlapudi AD, Cholkar K, Vadlapatla RK, Mitra AK. Aqueous Nanomicellar Formulation for Topical Delivery of Biotinylated Lipid Prodrug of Acyclovir: Formulation Development and Ocular Biocompatibility, J Ocul Pharmacol Ther, 30(1):49-58, 2014.
  44. Kwatra D1, Venugopal A1, Standing D1,2, Ponnurangam S1, Dhar A2,3, Mitra AK4, Anant S1,2., Bitter melon extracts enhance the activity of chemotherapeutic agents through the modulation of multiple drug resistance, Pharmacokinetics, Pharmacodynamics and Drug Transport and Metabolism, J. Pharm Sci., 102(12):4444-4454, 2013.
  45. Vadlapatla RK, Vadlapudi AD, Pal D, Mitra AK., Mechanisms of Drug Resistance in Cancer Chemotherapy: Coordinated Role and Regulation of Efflux Transporters and Metabolizing Enzymes, Curr Pharm Res., 19(40):7126-7140, 2013.
  46. Patel M, Mandava NK, Vadlapatla RK, Mitra AK., Recent patents and emerging therapeutics for HIV infections: A focus on protease inhibitors, Pharmaceu Patent Analyst 2(4):513-538, 2013.
  47. Barot M, Gokulgandhi MR, Agrahari V, Pal D, Mitra AK, Monocarboxylate transporter mediated uptake of moxifloxacin on human retinal pigmented epithelium cells, J. of Pharm & Pcol, 66(2):1-10, 2013.
  48. Vadlapatla RK, Vadlapudi AD, Ponnaluri VK, Pal D, Mukherji M, Mitra AK., Molecular Expression and Functional Activity of Efflux and Influx Transporters in Hypoxia Induced Retinal Pigment Epithelial Cells, Int J Pharm., 454(1):444-52, 2013.
  49. Vadlapatla RK, Vadlapudi AD, Mitra AK. Hypoxia-Inducible Factor-1 (HIF-1): A Potential Target for Intervention in Ocular Neovascular Diseases. Curr Drug Targets, 14(8):919-35, 2013.
  50. Vadlapudi AD, Vadlapatla RK, Earla R, Sirimulla S, Bailey JB, Pal D, Mitra AK, Novel Biotinylated Lipid Prodrugs of Acyclovir for the Treatment of Herpetic Keratitis (HK): Transporter Recognition, Tissue Stability and Antiviral Activity. Pharm Res., 30(8):2063-76, 2013.
  51. Patel Aǂ, Cholkar Kǂ, Agrahari V, Mitra AK, "An Overview of Ocular Drug Delivery Strategies", World J of Pharmacol, 2(2):47-64, 2013.ǂFirst two authors contributed equally to the preparation of manuscript.
  52. Wang Z, Luo S; Sheng Y, Samanta S, Pal D, Mitra AK. Stereoisomeric peptide prodrug modification to improve intestinal absorption of saquinavir: Synthesis and in vitro evaluation, Intl J. Phar & Eng (IJPE) ISSN 1(2):93-112, 2013.
  53. Barot M, Gokulgandhi M, Patel S, Mitra AK., Microvascular Complications and Diabetic Retinopathy: Recent Advances and Future Implications. Future Medicinal Chemistry, (March) 5(3):301-314, 2013
  54. Renukuntla J, Vadlapudi AD, Patel A, Boddu SHS, Mitra AK. Approaches for Enhancing Oral Bioavailability of Peptides and Proteins, Int J Pharm, (Feb) 447(1-2):75-93, 2013.
  55. Kwatra D, Subramaniam D, Ramamoorthy P, Standing D, Moran E, Velayutham R, Mitra AK, Umar S, and Anant S, Methanolic extracts of bitter melon inhibit colon cancer stem cells by affecting energy homeostasis and autophagy, Evidence-Based Complementary and Alternative Medicine, Jan (Article ID) 702869, pg 14, 2013.
  56. Patel M; Dalvi P; Gokulgandhi MR; Kesh S; Kohli T;Pal D; Mitra AK. Functional characterization and molecular expression of large neutral amino acid transporter (LAT1) in human prostate cancer cells, Int J Pharm (Feb) 443(1-2):245-253, 2013.
  57. Cholkar K, Patel SP, Vadlapudi AD, Mitra AK., Novel strategies for anterior segment ocular drug delivery, J Ocular Pharmacol & Therapeu,(Mar)9(2):106-123, 2013.
  58. Gaudana R; Gokulgandhi M; Varun K; Deep D; Mitra AK. Design and evaluation of a novel nanoparticulate based formulation encapsulating a HIP complex of lysozyme, Pharmaceutical Development and Technology, (May) 18(3):752-759. 2013.
  59. Vadlapudi AD and Mitra AK. Nanomicelles: An Emerging Platform for Drug Delivery to the Eye. Therapeutic Delivery, (Jan) 4(1):1-3, 2013.
  60. Vadlapudi AD, Vadlapatla RK, Mitra AK, Update On Emerging Antivirals For The Management Of Herpes Simplex Virus Infections: A Patenting Perspective, Recent Pat Antiinfect Drug Discov. (April) 8(1):55-67, 2013.
  61. Wang Z, Pal D, Patel A, Kwatra D, Mitra AK., Influence of overexpression of efflux proteins on the function and gene expression of endogenous peptide transporters in MDR-transfected MDCKII cell lines. Int J Pharm. (Jan)441(1-2):40-49, 2013.
  62. Vadlapudi AD, Vadlapatla RK, Pal D, Mitra AK. Biotin Uptake by T47D Breast Cancer Cells: Functional and Molecular Evidence of Sodium-Dependent Multivitamin Transporter (SMVT), Int J Pharm. (Jan)441(1-2):535-543, 2013.
  63. Barot M; Gokulgandhi MR; Pal D; Mitra AK, Mitochondrial localization of P-glycoprotein and peptide transporters in corneal epithelial cells--novel strategies for intracellular drug targeting, Exp Eye Res. (Jan)106:47-54, 2013.
  64. Tamboli V, Mishra GP, Mitra AK., Novel pentablock copolymer (PLA-PCL-PEG-PCL-PLA) based nanoparticles for controlled drug delivery: Effect of copolymer compositions on the crystallinity of copolymers and in vitro drug release profile from nanoparticles, Colloid Polym Sci., pg 1-11, Nov 2012.
  65. Vadlapudi AD, Vadlapatla RK, Pal D, and Mitra AK, Functional and Molecular Aspects of Biotin Uptake via SMVT in Human Corneal Epithelial (HCEC) and Retinal Pigment Epithelial (D407) Cells, The AAPS Journal,(Dec)14(4):832-842, 2012.
  66. Gokulgandhi MR, Vadlapudi AD, Mitra AK, Ocular Toxicity from Systemically Administered Xenobiotics, Expert Opin Drug Metab Toxicol. (Oct)10:1277-12791, 2012.
  67. Minocha M, Khurana V, Mitra AK, Determination of pazopanib (GW-786034) in mouse plasma and brain tissue by liquid chromatography-tandem mass spectrometry (LC/MS-MS), Journal of Chromatography B, (Jul)901:85-92, 2012.
  68. Patel M, Vadlapatla RK, Pal D, Mitra AK. Molecular and functional characterization of riboflavin specific transport system in rat brain capillary endothelial cells. Brain Research, (Aug)1468:1-10, 2012.
  69. Earla R, Cholkar K, Gunda S, Earla RL, Mitra AK, Bioanalytical method validation of rapamycin in ocular matrix by QTRAP LC-MS/MS: application to rabbit anterior tissue distribution by topical administration of rapamycin nanomicellar formulation, Journal of Chromatography-B, 908, 76-86, 2012.
  70. Kwatra D, Budda B, Vadlapudi AD, Vadlapatla RK, Pal D, Mitra AK, Transfected MDCK cell line with enhanced expression of CYP3A4 and P-Glycoprotein as a model to study their role in drug transport and metabolism. Mol Pharm. (Jun) 9(7):1877-1886, 2012.
  71. Patel M, Vadlapatla RK, Shah S, Mitra AK. Molecular expression and functional activity of sodium dependent multivitamin transporter in human prostate cancer cells. Int J Pharm. (Oct)436(1-2):324-331, 2012.
  72. Minocha M, Khurana V, Qin B, Pal D, Mitra AK, Co-administration strategy to enhance brainaccumulation of vandetanib by modulating P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp1/Abcg2) mediated efflux with m-TOR inhibitors,Int J Pharm., 434:306-314, 2012.
  73. Vadlapudi AD, Vadlapatla RK, Kwatra D, Earla R, Samanta SK, Pal D, Mitra AK, Targeted Lipid Based Drug Conjugates: A Novel Strategy for Drug Delivery, Int J Pharm. 434, 315-324, 2012.
  74. Minocha M, Khurana V, Qin B, Pal D,Mitra AK, Enhanced brain accumulation of pazopanib by modulating P-gp and Bcrp1mediated efflux with canertinib or erlotinib,Int J Pharm. 436(1-2); 127-134, 2012.
  75. Vavilala DT, Ponnaluri VKC, Vadlapatla RK, Pal D, Mitra AK, Mukherji M, Honokiol inhibits HIF pathway and hypoxia induced expression of Histone Lysine demethylases, Int J Pharm., Biochemical and Biophysical Res Communications. 422:369-374, 2012.
  76. Wang Z,Pal D, Mitra AK, Stereoselective Evasion of P-glycoprotein, CYP3A and Hydrolases by Peptide Prodrug Modification of Saquinavir, J Pharm Sci. 101(9):3199-3213, 2012.
  77. Barot M, Bagui M, Gokulgandhi MR, Mitra AK, Prodrug Strategies in Ocular Drug Delivery, Med Chem. (Jul) 8(4):753-768,2012.
  78. Gaudana RJ, Gokulgandhi MR, Boddu SHS,Mitra AK, “Recent Overview of Ocular Patents”, Recent Pat Drug Deliv Formul. (Aug)6(2):95-106, 2012.
  79. Ande A, Earla R, Jin M, Silverstein PS, Mitra AK, Kumar A, Kumar S., An LC-MS/MS method for concurrent determination of nicotine metabolites and the role of CYP2A6 in nicotine metabolite-mediated oxidative stress in SVGA astrocytes, Drug Alcohol Depend. (Sept) 125(1-2):49-59, 2012.
  80. Gokulgandhi MR, Barot M, Baguim M, Pal D, Mitra AK. "Transporter targeted lipid prodrugs of cyclic cidofovir: A potential approach for the treatment of cytomegalovirus retinitis", J Pharm Sci. (Sept)101(9):3249-3263, 2012.
  81. Cholkar K, Patel A, Vadlapudi AD, Mitra AK., “Novel nanomicellar formulation approaches for anterior and posterior segment ocular drug delivery”, Recent Patents on Nanomedicine, 2(2):82-95, 2012.
  82. Patel SP, Mitra AK. “An overview of recent patents on nanocarrier based ophthalmic drug delivery systems”, Recent Patents on Nanomedicine, 2(1):2-16, (15) 2012.
  83. Jwala J, Vadlapatla RK, Vadlapudi AD, Boddu SHS, Pal D, Mitra AK. Differential Expression of Folate Receptor-Alpha, Sodium-Dependent Multivitamin Transporter, and Amino Acid Transporter (B ((0, +))) in Human Retinoblastoma (Y-79) and Retinal Pigment Epithelial (ARPE-19) Cell Lines, J Ocul Pharmacol Ther. (Jun) 28(3):237-44, 2012.
  84. Vadlapudi AD, Vadlapatla RK, Mitra AK. Sodium Dependent Multivitamin Transporter (SMVT): A Potential Target for Drug Delivery, Curr Drug Targets. (Jun) 13(7):994-1003, 2012.
  85. Boddu SHS, Vaishya R, Jwala J, Vadlapudi A, Pal D, Mitra AK, et al.,  Preparation and Characterization of Folate Conjugated Nanoparticles of Doxorubicin using PLGA-PEG-FOL Polymer. Med Chem, 2:068-075, 2012
  86. Vadlapudi AD, Patel A, Cholkar K, and Mitra AK, Recent Patents on Emerging Therapeutics for the Treatment of Glaucoma, Age Related Macular Degeneration and Uveitis, Recent Patents on Biomedical Engineering, 5(1):83-101, 2012.
  87. Vadlapudi AD, Vadlapatla RK, Mitra AK. Current and Emerging Antivirals for the Treatment of Cytomegalovirus (CMV) Retinitis: an Update on Recent Patents. Recent Pat Antiinfect Drug Discov, 7(1):8-18, 2012.
  88. Jin M; Earla R; Shah A; Earla RL; Gupte R; Mitra AK; Kumar A; Kumar S, A LC-MS/MS method for concurrent determination of nicotine metabolites and role of CYP2A6 in nicotine metabolism in U937 macrophages: Implications in oxidative stress in HIV + Smokers, J Neuroimmune Pharmacol, 7(1):289-99, 2012.
  89. Vadlapatla RK; Vadlapudi AD; Kwatra D; Pal D; Mitra AK. Differential Effect of P-gp and MRP2 on Cellular Translocation of Gemifloxacin. Int J Pharm. 420(1):26-33, 2011.
  90. Ponnaluri VKC, Vadlapatla RK, Vavilala DT, Pal D, Mitra AK, Mukherji M. Hypoxia induced expression of histone lysine demethylases: Implications in oxygen-dependent retinal neovascular diseases. Biochem Biophys Res Commun, 415(2):373-377, 2011.
  91. Barot M, Gokulgandhi MR, Haghnegahdar M, Dalvi P, Mitra AK. Effect of Emergence of Fluoroquinolone Resistance on Intrinsic Expression of P-Glycoprotein Phenotype in Corneal Epithelial Cells. J Ocul Pharmacol Ther., 27(6):553-9, 2011.
  92. Barot M; Gokulgandhi M; Mitra AK, Mitochrondrial Dysfunction in Retinal Diseases, Curr Eye Res, 36(12):1069-77, 2011.
  93. Mishra GP, Bagui M, Tamboli V, Mitra AK, Recent applications of liposomes in ophthalmic drug delivery, J Drug Delivery, Vol. 2011, Article ID 863734, 1-14 pgs, 2011.
  94. Gaudana R, Khurana V. Parenky A, Mitra AK., Encapsulation of Protein-Polysaccharide HIP Complex in Polymeric Nanoparticles, J Drug Deliv.Vol. 2011, Article ID 458128, 1-7 pgs, 2011.
  95. Mishra GP, Tamboli V and Mitra AK, Effect of hydrophobic and hydrophilic additives on the sol-gel transition and release behavior of timolol maleate from polycaprolactone based hydrogel. Colloid Polym Sci. (Sep)289(14):1553-1562, 2011.
  96. Gaudana R, Parenky A, Vaishya R, Samanta SK, Mitra AK., Development and characterization of nanoparticulate formulation of a water soluble prodrug of dexamethasone by HIP complexation. J Microencapsul, 28(1):10-20, 2011.
  97. Jwala J, Boddu S.H.S, Paturi DK, Shah S, Smith SB, Pal D, Mitra AK,Functional Characterization of Folate Transport Proteins in Staten’s Seruminstitut Rabbit Corneal Epithelial Cell Line, Curr Eye Res, 36(5):404-416, 2011.
  98. Jwala J,. Boddu S.H.S, Shah S, Sirimulla S, Pal D, Mitra AK,, Ocular Sustained Release Nanoparticles Containing Stereoisomeric Di-Peptide Prodrugs of Acyclovir, J Ocul Pharmacol & Therapeu, 27(2):163-172, 2011.
  99. Pal D, Kwatra D, Minocha M, Paturi DK, Budda B, Mitra AK.. Efflux transporters- and cytochrome P-450-mediated interactions between drugs of abuse and antiretrovirals, Life Sci., 88:959-971, 2011.
  100. Minocha M, Mandava NK, Kwatra D, Pal D, Folk WR, Earla R, Mitra AK., Effect of short term and chronic administration of Sutherlandia frutescens on pharmacokinetics of nevirapine in rats, Int J Pharm,413(1-2):44-50, 2011.
  101. Luo S, Wang Z, Patel M, Khurana V, Zhu X, Pal D, Mitra AK., Targeting SVCT for enhanced drug absorption: Synthesis and in vitro evaluation of a novel vitamin C conjugated prodrug of saquinavir, Int J Pharm, 414:77-85, 2011.
  102. Tamboli V; Mishra GP; Mitra AK, Polymeric vectors for ocular gene delivery, Therapeutic Delivery (Future Science), 2(4):523-536, 2011.
  103. Mishra GP, Tamboli V, Jwala J, Mitra AK, Recent patents and emerging therapeutics in the treatment of allergic conjunctivitis, Recent Pat Inflamm Allergy Drug Discov, 5:26-36, 2011.
  104. Katragadda S, Zhu X, Talluri SR, Mitra AK, Small Neutral Amino Acid Ester Prodrugs of AcyclovirTargeting Amino Acid Transporters on the Cornea: PossibleAntiviral Agents Against Ocular HSV-1 Infections, Ophthalmology and Eye Diseases, 2:43-56, 2010.
  105. Kumar S, Earla R, Jin M, Mitra AK, Kumar A, Effect of ethanol on spectral binding, inhibition, and activity of CYP3A4 with an antiretroviral drug nelfinavir. Biochem Biophys Res Commun. 402:163-167, 2010.
  106. Boddu SHS; Jwala J; Chowdhury MR; Mitra AK, In vitro evaluation of a targeted and sustained release system for retinoblastoma cells using doxorubicin as a model drug, J Ocul Pharmacol & Therapeu, 26(5):459-468, 2010.
  107. Talluri RS; Hariharan S; Karla PK; Mitra AK, Drug delivery to cornea and conjunctiva: Esterase- and protease-directed prodrug design, Encyclopedia of Eye, 2:42-53, 2010.
  108. Kwatra D; Vadlapatla RK; Vadlapudi AD; Pal D; Mitra AK, Interaction of gatifloxacin with efflux transporters: A posible mechanism for drug resistance, Int J Pharmaceu 395(1-2):114-121, 2010.
  109. Janoria KG; Boddu SHS; Natesan S; Mitra AK, Vitral pharmacokinetics of peptide-transporter-targeted prodrugs of ganciclovir in conscious animals, J. Ocul Pharmacol & Therapeu, 26(3):265-271, 2010.
  110. Boddu S.H.S.; Gunda S; Earla R; Mitra AK, Ocular microdialysis: A continuous sampling technique to study pharmacokinetics and pharmacodynamics in the eye. Bioanalysis, 2(3):487-507, 2010.
  111. Gaudana R; Ananthula HK; Parenky A; Mitra AK, Ocular Drug Delivery, The AAPS Journal, 12(3):348-360, 2010.
  112. Luo S, Pal D, Shah SJ, Kwatra D, Paturi DK, Mitra AK; Effect of HEPES buffer on the uptake and transport of P-Glycoprotein substrates and large neutral amino acids, Mol. Pharm., 7(2):412-420, 2010
  113. Velagaleti PR; Anglade E; Khan IJ; Gilger BC; Mitra AK. Topical delivery of hydrophobic drugs using a novel mixed nanomicellar technology to treat diseases of the anterior & posterior segments of the eye, Nanomicellar Technology, Drug Del Tech,10(4):42-47, 2010.
  114. Missel P; Chastain J; Mitra A, Kompella U; Kansara V; Duvvuri S; Amrite A; Cheruvu N, In vitro transport and partitioning of AL-4940, Active metabolite of angiostatic agent anecortave acetate, in ocular tissues of the posterior segment. J. Ocular Pharmacol & Therap, 26(2):137-145, 2010.
  115. Mandava N, Oberoi RK, Minocha M, Mitra AK; Transporter targeted drug delivery, J. Drug Del. Sci Tech., 20(2):89-99, 2010.
  116. Earla R; Boddu S.H.S; Cholkar K; Hariharan S; Jwala J; Mitra AK, Development and validation of a fast and sensitive bioanalytical method for the quantitative determination of glucocorticoids – Quantitative measurement of dexamethasone in rabbit ocular matrices by liquid chromatography tandem mass spectrometry, J Pharm & Biomedical Analysis, 52:525-533, 2010.
  117. Boddu S.H.S; Jwala J; Vaishya R; Earla R; Karla PK; Pal D; Mitra AK, Novel Nanoparticulate Gel Formulations of Steroids for the Treatment of Macular Edema, J Ocul Pharmacol Ther., 26(1):37:48, 2010.
  118. Hariharan S; Minocha M; Mishra G; Pal D; Krishna R; Mitra AK, Interaction of ocular hypotensive agents (PGF2 analogs—bimatoprost, latanoprost, and travoprost) with MDR efflux pumps on the rabbit cornea, J. Ocul Pharmacol Therap 25(6):487-497, 2009.
  119. Paturi DK, Kwatra D, Ananthula HK, Pal D, Mitra AK, Identification and functional characterization of breast cancer resistance protein in human bronchial epithelial cells (Calu-3), Int J. Pharm, 384:32-38, 2009.
  120. Talluri RS; Gaudana R; Hariharan S; Mitra AK. Pharmacokinetics of stereoisomeric dipeptide prodrugs of acyclovir following intravenous and oral administrations in rats: A study involving in vivo corneal uptake of acyclovir following oral dosing, Ophthalmology and Eye Diseases, 1:21-31, 2009. 
  121. Talluri RS; Gaudana R; Hariharan S; Jain R; Mitra AK, Disposition kinetics of a dipeptide ester prodrug of acyclovir and its metabolites following intravenous and oral administrations in rat, Clinical Research and Regulatory Affairs, 26(3):65–72, 2009.
  122. Hariharan S; Thakkar NR; Mitra AK, Transporter-Targeted Drug Delivery to the Retina, Retina Today (Drug Delivery to the Posterior Segment), May/June, 4 (4):57-62, 2009.
  123. Mitra AK. Role of Transporters in Ocular Drug Delivery System, Pharm Res, 26(5):1192-1196, 2009.
  124. Gaudana R, Jwala J, Boddu SH, Mitra AK. Recent Perspectives in Ocular Drug Delivery. Pharm Res 26(5):1197-1216, 2009.
  125. Karla P; Quinn TL; Henderdon BL; Thomas P; Pal D; Mitra AK. Expression of Multidrug resistance associated protein 5 (MRP5) on cornea and its role in drug efflux. JOPT 25(2), J. Ocular Pharmacol & Therap, 25(2):121-132, 2009.
  126. Hariharan S; Gunda S; Mishra GP; Pal D; Mitra AK. Enhanced corneal absorption of erythromycin by modulating P-glycoprotein and MRP mediated efflux with corticosteroid. Pharm Res, 26(5):1270-1282, 2009.
  127. Janoria KG; Boddu, Sai HS; Wang Z; Paturi DK; Samanta S; Pal D; Mitra AK. Vitreal Pharmacokinetics of Biotinylated Ganciclovir: Role of Sodium-Dependent Multivitamin Transporter Expressed on Retina, J. Ocular Pharmacol & Therap, 25(1):39-49, 2009.
  128. Karla PK; Earla R; Boddu SH; Johnston TP; Pal D; Mitra AK. Molecular expression and functional evidence of a drug efflux pump (BCRP) in human corneal epithelial cells, Curr Eye Res, 34:1-9, 2009.
  129. Katragadda S; Jain R; Kwatra D; Hariharan S; Mitra AK. Pharmacokinetics of amino acid ester prodrugs of acyclovir after oral administration: Interaction with the transporters of Caco-2- cells, Int. J. Pharm.,362(1-2):93-101 2008.
  130. Jain R; Agarwal S; Mandava NK; Sheng Y; Mitra AK. Interaction of Dipeptide Prodrugs of Saquinavir with Multidrug Resistance Protein-2 (MRP-2): Evasion of MRP-2 Mediated Efflux, Int. J Pharm.,362(1-2):44-51. 2008
  131. Talluri RS; Samanta SK; Gaudana R; Mitra AK. Synthesis, metabolism and cellular permeability of enzymatically stable dipeptide prodrugs of acyclovir, Int. J. Pharm., 361:118-124, 2008.
  132. Boddu SHS; Jwala J; Janoria D; Pal D; Mitra AK. Development of Steroid-Nanoparticles for the Treatment of Macular Edema, JIDR J. Interdis Res, 2(1):81-99, 2008.
  133. Agarwal S; Boddu SHS; Jain R; Samanta S; Pal D; Mitra AK. Peptide prodrugs: Improved oral absorption of Lopinavir, a HIV protease inhibitor, Int. J. Pharm/Sci Dir., 359, 7-14, 2008.
  134. Luo S; Wang Z; Kansara V; Pal D; Mitra AK. Activity of a sodium-dependent Vitamin C transporter (SVCT) in MDCK-MDR1 cells and mechanism of ascorbate uptake, Int. J. Pharm., 358:168-176, 2008. 
  135. Katragadda S; Gunda S; Hariharan S; Mitra AK.  Ocular pharmacokinetics of Acyclovir amino acid ester prodrugs in the anterior chamber:  Evaluation of their utility in treating ocular HSV infections, Int J. Pharm, Int. J. Pharm/Science Direct, 359:15-24, 2008. 
  136. Kansara V; Paturi D; Luo S, Gaudana, R; Mitra AK. Folic Acid Transport via High Affinity Carrier-Mediated System in Human Retinoblatoma Cells, Int. J. Pharm/Sci Dir, 355:1-2, 210-219, 2008.
  137. Atluri H; Talluri RS; Mitra AK.  Functional Activity of a Large Neutral Amino Acid Transporter (LAT) in Rabbit Retina: A Study Involving the in vivo Retinal Uptake and Vitreal Pharmacokinetics of L-phenyl Alamine, Int. J. Pharm., 347:1-2, 23-30, 2008. 
  138. Jain R; Duvvuri S, Kansara V, Mandava NK, Mitra AK, Intestinal Absorption of novel-dipeptide prodrugs of a saquinavir in rats, .Int. J. Pharm/Sci Dir, 336, 233-240, 2007.
  139. Agarwal S; Pal D; Mitra AK. Both P-gp and MRP2 Mediate Transport of Lopinavir, A Protease Inhibitor, ScienceDirect, Int J. Pharm., 339(1-2):139-147, 2007.
  140. Aggarwal D, Pal D, Mitra AK, Kaur IP. Study of extent of ocular absorption of acetazolamide from a developed niosomal formulation, by microdialysis sampling of aqueous humor. Int. J. Pharm. 338(1-2):21-26, 2007.
  141. Denora N; Laquintana V; Lopedota A; Serra M; Dazzi L; Biggio G; Pal D; Mitra AK, Latrofa A; Trapani G; Liso G.  Novel L- Dopa and Dopamine Prodrugs Containing a 2-Phenyl-imidazopyridine Moiety. Pharm. Res. 24(7):1309-1324, 2007.
  142. Chittchang M, Mitra AK, Johnston TP. Interplay of Secondary Structure and Charge on the Diffusion of a Polypeptide through Negatively Charged Aqueous Pores. Pharm. Res. 24(3):502-511, 2007.
  143. Kansara V; Hao Y; Mitra AK. Dipetide Monoester Ganciclovir Prodrugs for Trans-scleral Drug Delivery: Targeting the Oligopeptide Transporter on Rabbit Retina, J. Ocul Pharmacol. & Therap, 23(4):321-334, 2007.
  144. Janoria KG; Gunda S; Boddu SHS; Mitra AK.  Novel Approaches to Retinal Drug Delivery, Expert Opinion in Drug Delivery, 4(4):371-388, 2007.
  145. Janoria KG, Hariharan S, Dasari CR, Mitra AK. Recent Patents and Advances in Ophthalmic Drug Delivery. Recent Patents on Drug Delivery & Formulation, Vol. 1, No 2, 161-170, 2007.
  146. Janoria KG; Mitra AK. Effect of Lactide/Glycolide Ratio on the In Vitro Release of Ganciclovir and its Lipophilic Prodrug (GCV - Monobutyrate) from PLGA Microspheres. Int. J. Pharm/ScienceDirect, 338(1-2):133-141, 2007.
  147. Duvvuri S; Janoria K; Pal; Mitra AK. Controlled delivery of ganciclovir to the retina with drug loaded PLGA microspheres dispersed in PLGA-PEG-PLGA gel: A novel intravitreal delivery system for the treatment of cytomegalovirus retinitis. J Ocul Pharmacol Ther., 23(3):264-274, 2007.
  148. Pal D; Mitra AK. CYP3A4 and MDR Mediated Interactions in Drug Therapy, Informa HealthCare, Clin Res & Reg Affairs, 23(3):125-163, 2007.
  149. Karla PK, Pal D, Quinn T. Mitra AK. Molecular Evidence and Functional Expression of a Novel Drug Efflux Pump (ABCC2) in Human Corneal Epithelium and Rabbit Cornea and its Role in Ocular Drug Efflux. Int. J. Pharm., 336(1):12-21, 2007. 
  150. Karla PK, Pal D, Mitra AK. Molecular Evidence and Functional Expression of Multidrug Resistance Associated Protein (MRP) in Rabbit Corneal Epithelial Cells, Exp. Eye Res., 84(1):53-60, 2007. 
  151. Kaur IP, Mitra AK, Aggarwal D. Development of a vesicular system for effective ocular delivery of acetazolamide. A comprehensive approach and successful venture. J. Drug Del. Sci. Tech., 17 (1), 33-41, 2007.
  152. Agarwal S, Jain R, Pal D, Mitra AK. Functional Characterization of Peptide Transporters in MDCKII-MDR1 Cell Line as a Model for Oral Absorption Studies, Int J Pharm, ScienceDirect 332:147-152, 2007.
  153. Majumdar S; Kansara V; Mitra AK.  Vitreal Pharmacokinetics of Dipeptide Monoester Prodrugs of Ganciclovir, J. Ocul Pharmacol. Therap, 22(4):231-241, 2006. 
  154. Majumdar S; Mitra AK. Approaches Towards Enhanced Transepithelial Drug Delivery. Discovery Medicine, 6(36):229-233, 2006.
  155. Gunda S, Hariharan S, Mitra AK. Corneal Absorption and Anterior Chamber Pharmacokinetics of Dipeptide Monoester Prodrugs of Ganciclovir (GCV): In Vivo Comparative Evaluation of These Prodrugs with Val-GCV and GCV in Rabbits. J Ocul Pharmacol Ther., 22(6):465-476, 2006.
  156. Janoria KG; Hariharan S; Paturi D; Pal D; Mitra AK. Biotin Uptake by Rabbit Corneal Epithelial Cells: Role of Sodium-Dependent Multivitamin Transporter (SMVT), Current Eye Research, 31(10):797-809, 2006. 
  157. Hariharan S; Janoria KG; Gunda S; Zhu X; Pal D; Mitra AK. Identification and Functional Expression of a Carrier-Mediated Riboflavin Transport System on Rabbit Corneal Epithelium, Current Eye Research, 31(10):811-824, 2006.
  158. Anand BS; Katragadda S; Mitra AK. In Vivo Ocular Pharmacokinetics of Dipeptide Ester Prodrugs Using Microdialysis in Rabbits, Mol. Pharm., 3(4):431-440, 2006.
  159. Katragadda S; Talluri SR; Mitra AK. Simultaneous Modulation of Transport and Metabolism of Acyclovir Prodrugs Across Rabbit Cornea: An Approach Involving Enzyme Inhibitors, Int J Pharm., 320(1-2):104-113, 2006.
  160. Pal D; Mitra AK.  MDR and CYP3A4 Interactions, J. Neuroimmune Pharmacol 1, 323-339, 2006. 
  161. Majumdar S, Mitra AK. Chemical modification and formulation approaches to elevated drug transport across cell membranes. Expert Opin Drug Deliv. Jul; 3(4):511-27, 2006.
  162. Talluri SR; Katragadda S; Pal D; Mitra AK.  Mechanism of L-Ascorbic Acid Uptake by Rabbit Corneal Epithelial Cells: Evidence for the Involvement of Sodium-Dependent Vitamin C Transporter 2, Current Eye Research, 31(6):481-489, 2006. 
  163. Luo S; Kansara VS; Zhu X; Mandava NK; Pal D; Mitra AK.  Functional Characterization of Sodium-Dependent Multivitamin Transporter in MDCK-MDR1 Cells and Its Utilization as a Target for Drug Delivery, Molecular Pharmaceutics, 3(3):329-435, 2006.
  164. Kansara V.,Mitra AK. Evaluation of an Ex Vivo Model Implication for Carrier-Mediated Retinal Drug Delivery, Current Eye Research, 31(5):415-426, 2006.
  165. Kansara V; Luo S; Balasubrahmanyam B; Pal D; Mitra AK.  Biotin Uptake and Cellular Translocation in Human Derived Retinoblastoma Cell Line (Y-79): A Role of hSMVT System, International Journal of Pharmaceutics, 312(1-2):43-52, 2006.
  166. Katragadda S, Talluri RS; Mitra AK.  Modulation of P-Glycoprotein-Mediated Efflux by Prodrug Derivatization: An Approach Involving Peptide Transporter-Mediated Influx Across Rabbit Cornea, J Ocul Pharmacol Ther., 22(2):110-120, 2006.
  167. Pal D; Mitra AK.  MDR- and CYP3A4-Mediated Drug—Herbal Interactions, Life Sciences,78, 2131-2145, 2006. 
  168. Duvvuri S; Janoria KG; Mitra AK. Effect of Polymer Blending on the Release of Ganciclovir from PLGA Microspheres, Pharm Res, 23(1):215-223, 2006. 
  169. Katragadda S; Talluri RS; Pal D; Mitra AK.  Identification and Characterization of a Na+-Dependent Neutral Amino Acid Transporter, ASCT1, in Rabbit Corneal Epithelial Cell Culture and Rabbit Cornea, Curr Eye Res, 30(11):989-1002, 2005.  
  170. Duvvuri S, Rittenhouse KD, Mitra AK., Microdialysis Assessment of Drug Delivery Systems for Vitreoretinal Targets, Adv. Drug Deliv. Rev., 57(14):2080-2091, 2005. 
  171. Majumdar S; Nashed YE; Patel K, Jain R; Itahashi M; Neumann DM; Hill JM; and Mitra AK. Dipeptide Monoester Ganciclovir Prodrugs for Treating HSV-1-induced Corneal Epithelial and Stromal Keratitis: In Vitro and In Vivo Evaluations. J Ocul Pharmacol Ther., 21(6):463-474, 2005. 
  172. Duvvuri S, Janoria KG, Mitra AK.  Development of a Novel Formulation Containing Poly(D,L-lactide-co-glycolide) Microspheres Dispersed in PLGA-PEG-PLGA Gel for Sustained Delivery of Ganciclovir, J. Controlled Released, 108(2-3):282-293, 2005. 
  173. Patel K, Trivedi S, Luo S, Zhu X, Pal D, Kern ER, Mitra AK. Synthesis, Physicochemical Properties and Antiviral Activities of Ester Prodrugs of Ganciclovir. Int J Pharm., 305, 75-89, 2005.
  174. Kansara V., Pal D, Jain R, Mitra AK. Identification and Functional Characterization of Riboflavin Transporter on Human Derived Retinoblastoma Cell Line (Y-79): Mechanisms of Cellular Uptake and Translocation, J. Ocul Pharmacol Ther., 21(4):275-287, 2005. 
  175. Jain R, Agarwal S, Majumdar S, Zhu X, Pal D, Mitra AK.  Evasion of P-gp Medicated Cellular Efflux and Permeability Enhancement of HIV-Protease Inhibitor Saquinavir by Prodrug Modification, Int J. Pharm, 303(1-2):8-19, 2005. 
  176. Katragadda S, Budda B, Anand BS, Mitra AK. Role of Efflux Pumps and Metabolizing Enzymes in Drug Delivery.Expert Opinion in Drug Delivery, 2(4):683-705, 2005.
  177. Dey S, Mitra AK. Transporter and Receptors in Ocular Drug Delivery: Opportunities and Challenges, Exp Opin, Drug Deliv 2(2):201-204, 2005.
  178. Majumdar, S, Gunda S, Pal D, Mitra AK. Functional Activity of a Monocarboxylate Transporter, MCT1, in the Human Retinal Pigmented Epithelium Cell Line, ARPE-19, Molecular Pharmaceutics, 2(2): 109-117, 2005. 
  179. Salamat-Miller N, Chittchang M, Mitra AK, Johnston TP, A Randomly Coiled, High-Molecular-Weight Polypeptide Exhibits Increased Paracellular Diffusion in Vitro and in Situ Relative to the Highly Ordered -Helix Conformer, Pharm Res, 22(2): 245-254, 2005. 
  180. Patel J; Buddha B; Dey S; Pal D; Mitra AK. In Vitro Interaction of the HIV Protease Inhibitor Ritonavir with Herbal Constituents: Changes in P-gp and CYP3A4 Activity, Amer J Therap. 11:262-277, 2004.
  181. Sikri V; Pal D; Jain R; Kalyani D; Mitra AK, Cotransport of macrolide and fluoroquinolones, a beneficial interaction reversing P-glycoprotein efflux, Amer J. Therap., 11:433-442, 2004.
  182. Duvvuri S, Majumdar S, and Mitra AK. Role of Metabolism in Ocular Drug Delivery, Current Drug Metabolism, 5(6):507-515, 2004. 
  183. Dey S, Gunda S, Mitra AK. Pharmacokinetics of Erythromycin in Rabbit Corneas After Single-Dose Infusion: Role of P-Glycoprotein as a Barrier to in Vivo Ocular Drug Absorption, J Pharmacol Exp Ther, 311(1):246-255, 2004. 
  184. Anand BS, Katragadda S, Mitra AK. Pharmacokinetics of Novel Dipeptide Ester Prodrugs of Acyclovir after Oral Administration: Intestinal absorption and Liver Metabolism, J Pharmacol Exp Ther., 311(2):659-667, 2004.
  185. Jain-Vakkalagadda B, Pal D, Gunda S, Nashed Y, Ganapathy V, Mitra AK. Identification of a Na+ -Dependent Cationic and Neutral Amino Acid Transporter, B0,+, in Human and Rabbit Cornea, Molecular Pharmaceutics,1(5):338 -346, 2004.
  186. Anand BS, Katragadda S, Nashed YE, Mitra AK. Amino Acid Prodrugs of Acyclovir as Possible Antiviral Agents Against Ocular HSV-1 Infections: Interactions the with Neutral and CationicAmino Acid Transporter on the Cornea epithelium. Curr Eye Res, 29(2-3):153-166, 2004. 
  187. Majumdar S, Macha S, Pal D, Mitra AK.  Mechanism of ganciclovir uptake by rabbit retina and human retinal pigmented epithelium cell line ARPE-19, Curr Eye Res, 29(2-3):127-136, 2004. 
  188. Anand BS, Atluri H, Mitra AK.  Validation of an Ocular Microdialysis Technique in Rabbits with Permanently Implanted Vitreous Probes: Systemic and Intravitreal Pharmacokinetics of Fluorescein, International Journal of Pharmaceutics, 281:79-88, 2004.
  189. Majumdar S, Macha S, Nashed Y and Mitra AK. Expression of Peptide Transporters on Rabbit Retina: A Strategy to Improve Retinal Delivery of Ganciclovir,Letters in Drug Design and Discovery. 1(1): 73-77, 2004.
  190. Majumdar S, Duvvuri S and Mitra AK Bioreversion and Oral Bioavailability of the L-Valine Dipeptide Ester Prodrug of Acyclovir, Val-valacyclovir, in Sprague Dawley Rats. Clinical Research in Regulatory Affairs, 21(1): 67 – 79, 2004.
  191. Gandhi M. D, Pal D and Mitra A.K. Identification and functional characterization of a Na+-independent large neutral amino acid transporter (LAT2) on ARPE-19 cells. International Journal of Pharmaceutics, 275(1-2):189-200, 2004.
  192. Majumdar S, Duvvuri S and Mitra A.K. Membrane transporter/receptor-targeted prodrug design: strategies for human and veterinary drug development, Advanced Drug Delivery Reviews, 56(10): 1437-1452, 2004.
  193. Jain R, Majumdar S, Nashed Y, Pal D and Mitra A.K Circumventing P-Glycoprotein Mediated Cellular Efflux of Quinidine by its Prodrug Derivatization, Molecular Pharmaceutics.1 (4), 290 -299, 2004.
  194. Patel J, Buddha B, Dey S, Pal D, Mitra AK.Interaction of Protease Inhibitors with Herbal Agents: P-gp and CYP3A4 Activity in Caco-2 Cells,American Journal of Therapeutics.11(4):262-277, 2004.
  195. Patel J, Hussain AM, Pal, D, Mitra AK.  A Mathematical Simulation that Explains the Coordinated Function of P-Glycoprotein and CYP3A4 in Limiting the Transport of Anti-HIV Agents Across Caco-2 Cells, American Journal of Therapeutics, 11(2):114-123, 2004.
  196. Hussain AM, Mitra AK.  Effect of reactive oxygen species on the metabolism of tryptophan in rat brain:  Influence of age.  Molecular and Cellular Biochemistry 258, 145-153, 2004. 
  197. Macha S, Duvvuri S, Mitra AK. Ocular Disposition of Novel Lipophilic Diester Prodrugs of Ganciclovir following Intravitreal Administration using Microdialysis. Current Eye Research, 28(2):77-84, 2004.
  198. Majumdar S, Macha S, Nashed Y, Mitra AK.  Expression of Peptide Transporters on the Rabbit Retina:  A Strategy to Improve Retinal Delivery of Ganciclovir, Letters in Drug Design and Discovery, 1 (1):73-77, 2004.
  199. Atluri H, Anand BS, Patel J, Mitra AK. Mechanism of a Model Dipeptide Transport Across Blood-Ocular Barriers Following Systemic Administration. Experimental Eye Research, 78(4), 815-822, 2004.
  200. Duvvuri S, Gandhi MD, Mitra AK. Effect of P-glycoprotein on the Ocular Disposition of a Model Substrate, Quinidine. Current Eye Research, 27(6):345-353, 2003. 
  201. Johnston TP, Salamat-Miller N, Alur HH, Mitra AK. An Attempt to Modulate the Microporous Diffusion of a Model Polypeptide by Altering Its Secondary Structure. Drug Delivery 10, 65-72, 2003.
  202. Tirucherai, GS, Mitra AK.  Effect of Hydroxypropyl Beta Cyclodextrin on Solubility, Stability and Corneal Permeation of Acyl Ester Prodrugs of Ganciclovir.  AAPS Pharm Sci Tech, 4(3), 357-368, 2003. 
  203. Majumdar S, Tirucherai GS, Mitra AK.  Differential Expression of Nucleoside and Nucleobase transporters on the Rabbit Corneal Ephithelial Cell Line (SIRC) and Isolated Rabbit Cornea.  AAPS Pharm Sci, 5(2):145-158, 2003. 
  204. Nashed YE, Mitra AK.  Synthesis and Characterization of Novel Dipeptide Ester Prodrugs of Acyclovir.  Spectrochimica Acta, Part A, 59, 2033-2039, 2003. 
  205. Majumdar S, Gunda S, Mitra AK.  Functional Expression of a Sodium Dependent Nucleoside Transporter on Rabbit Cornea:  Role in Corneal Permeation of Acyclovir and Idoxuridine.  Current Eye Research, 26(3,4):175-183, 2003.
  206. Anand BS, Nashed YE, Mitra AK.  Novel Dipeptide Prodrugs of Acyclovir for Ocular Herpes Infections:  Bioreversion, Antiviral activity and Transport Across Cornea.  Current Eye Research, 26(3,4):151-163, 2003.
  207. Jain-Vakkalagadda B, Dey S, Pal D, Mitra AK.  Identification and Functional Characterization of a NA+-Independent Large Neutral Amino Acid Transporter LATI on Rabbit Cornea.  Investigative Ophthalmology and Visual Sciences, 44(7):2919-2927, 2003. 
  208. Anand BS, Hill JM, Dey S, Moruyama J, Bhattacharjee P. Myles ME, Nashed YE, Mitra AK.  In Vivo Antiviral Efficacy of a Dipeptide Acyclovir Prodrug, Val-Val-Acyclovir Against HSV-1 Epithelial and Stromal Keratitis in the Rabbit Eye Model.  Investigative Ophthalmology and Visual Sciences, 44(6):2529-2534, 2003. 
  209. Dey S, Patel J, Anand BS, Vakkalagadda-Jain B, Reddy PK, Pal D, Ganapathy V, Mitra AK.  Molecular Evidence and Functional Expression of P-Glycoprotein (MDR1) in Human and Rabbit Cornea and Corneal Epithelial Cell Lines.  Investigative Ophthalmology and Visual Sciences, 44(7):2909-2918, 2003. 
  210. Dias CS, Nashed YE, Atluri H, Mitra AK.  Ocular Penetration of acyclovir and its peptide prodrugs valacyclovir and val-valacyclovir following systemic administration in rabbits:  An evaluation using ocular microdialysis and LC-MS.  Current Eye Research, 25(4):243-252, 2003.
  211. Dey S, Anand BS, Patel J, Mitra AK.  Transporters/receptors in the anterior chamber:  Pathways to explore ocular strategies.  Expert Opinion on Biological Therapy 3(1):23-44, 2003. 
  212. Duvvuri S, Majumdar S, Mitra AK.  Drug delivery to the retina:  Challenges and opportunities.  Expert Opinion on Biological Therapy 3(1):45-56, 2003.
  213. Tirucherai GS, Dias CS, Mitra AK.Corneal Permeation of Ganciclovir:  Mechanism of Ganciclovir Permeation Enhancement by Acyl Ester Prodrug Design.  Journal of Ocular Pharmacology Therapeutics, 18(6):535-548, 2003.
  214. Anand BS, Patel J, Mitra AK.  Interactions of the Dipeptide Ester Prodrugs of Acyclovir with the Intestinal Oligopeptide Transporter:  Competitive inhibition of Glycylsarcosine Transport in Human Intestinal cell Line-Caco-2.  Journal of Pharmacology and Experimental Therapeutics, 304(2), 781-791, 2003. 
  215. Atluri H, Mitra AK.  Disposition of short-Chain Aliphatic Alcohols in Rabbit vitreous by Ocular Microdialysis.  Experimental Eye Research, 76(3):315-320, 2003. 
  216. Dias CS, Mitra AK.  Posterior Segment Ocular Pharmacokinetics using microdialysis in a conscious rabbit model.  Investigative Ophthalmology and Visual Science 44(1):300-305, 2003.
  217. Udata C, Patel J, Pal D, Hejchman E, Cushman M, Mitra AK.  Enhanced Transport of a Novel Anti-HIV Agents – Cosalane and its Congeners across Human Intestinal Epithelial (Caco-2) Cell Monolayers.  International Journal of Pharmaceutics, 250:157-168, 2003.
  218. Chittchang M, Salamat-Miller N. Alur HH, Velde D.G.V., Mitra AK, Johnston TP.  Poly(L-lysine) as a model drug macromolecule with which to investigate secondary structure and microporous membrane transport, part 2: diffusion studies, Journal of Pharmacy and Pharmacology (JPP), 54:1497-1505, 2002. 
  219. Patel J., Mitra AK.  ACH-126443 Achillion/Yale University, Current Opinion in Investigational Drugs, 3(11):1580-1584, 2002. 
  220. Martinez M, Amidon G, Clarke L, Jones W, Mitra AK, Riviere J.  Applying the biopharmaceutics classification system to veterinary pharmaceutical products Part II. Physiological considerations.  Advanced Drug Delivery Reviews, 54:825-850, 2002. 
  221. Patel J, Pal D, Vangala V, Gandhi M, Mitra AK.Transport of HIV-Protease Inhibitors Across 1-25 di-Hydroxy Vitamin D3-Treated Calu-3 Cell Monolayer: Modulation of P-Glycoprotein Activity.  Pharmaceutical Research, 19(11):1696-1703, 2002. 
  222. Anand B, Jain-Vakkalagadda B, Yang, C, Pal D, Mitra AK.  Carrier mediated uptake of L-tyrosine and its competitive inhibition by mode tyrosine linked compounds in a rabbit corneal cell line (SIRC)  strategy for the design of transporter/receptor targeted prodrugs.  International Journal of Pharmaceutics, 247:115-125, 2002. 
  223. Anand BS, Mitra AK.  Mechanism of corneal permeation of L-Valyl ester of acyclovir:  targeting the oligopeptide transporter on the rabbit cornea, Pharmaceutical Research, 19(8):1194-1202, 2002.
  224. Anand BS, Dey S, Mitra AK.  Current prodrug strategies via membrane transporters/receptors, Expert Opinion in Biotherapeutic Technologies 2(6):607-620, 2002.
  225. Alur HH, Johnston TP, Mitra AK.  Peptides and proteins:  Buccal absorption, Encyclopedia of Pharmaceutical Technology, Second Edition, (Eds. James Swarbrick and James C. Boylan), Marcel Dekker, Inc., NY, 2081-2095, 2002.
  226. Macha S, Mitra AK.  Ocular disposition of ganciclovir and its monoester prodrugs following intravitreal administration using microdialysis, Drug Metabolism and Disposition, 30:(6)670-675, 2002.
  227. Chittchang M, Alur HH, Mitra AK, Johnston TP.  Poly(L-lysine) as a model drug macromolecule with which to investigate secondary structure and membrane transport, part 1: physicochemical and stability studies, Journal of Pharmacy and Pharmacology (JPP), 54:315-323, 2002. 
  228. Pezron I, Mitra R, Pal D, Mitra AK.Insulin aggregation and asymmetric transport across human bronchial epithelial cell monolayers (Calu-3), Journal of Pharmaceutical Sciences 91(4):1135-1146, 2002. 
  229. Dias CS., Anand BS, Mitra AK.Effect of mono- and di-acylation on the ocular disposition of ganciclovir: physicochemical properties, ocular bioreversion, and antiviral activity of short chain ester prodrugs, Journal of Pharmaceutical Sciences, 91(3):660-668, 2002.
  230. Triucherai GS, Pezron I, Mitra AK.Novel approaches to nasal delivery of peptides and proteins, S.T.P. Pharm Sciences 12(1):3-12, 2002. 
  231. Pezron I, Tirucherai G.S, Duvvuri S, Mitra AK.Prodrug strategies in nasal drug delivery, Expert Opin. Ther. Patents, 12(3):1-10, 2002.
  232. Kuchimanchi KR, Gandhi MD, Sheta RR, Johnston TP, Santhosh K C, Cushman M, Mitra AK.  Intestinal absorption and biodistribution of cosalane and its amino acid conjugates: novel anti-HIV agents, International Journal of Pharmaceutics, 231, 197-211, 2002. 
  233. Pezron I, Tirucherai GS, Mitra AK.Time-dependent loss of radioactivity counts associated with paracellular markers in the presence of cyclodextrin, International Journal of Pharmaceutics, 231, 237-240, 2002.
  234. Kuchimanchi KR; Ahmed MS; Johnston TP; Mitra AK. Binding of Cosalane―A Novel Highly Lipophilic Anti-HIV Agent―to Albumin and Glycoprotein, J. Pharm Sci., 90(5):659-665, 2001.
  235. Macha S, Mitra AK.  Ocular pharmacokinetics of cephalosporins using microdialysis, Journal of Ocular Pharmacology & Therapeutics, 17(5):485-498, 2001.
  236. Tak RV, Pal D, Gao H, Dey S, Mitra AK.  Transport of acyclovir ester prodrugs through rabbit cornea and SIRC-rabbit corneal epithelial cell line, Journal of Pharmaceutical Sciences, 90(10) 1505-1515, 2001.
  237. Patel J, Mitra AK.  Strategies to Overcome Simultaneous P-glycoprotein Mediated Efflux and CYP3A4 Mediated Metabolism of Drugs, Pharmacogenomics 2(4):401-415, 2001. 
  238. Kuchimanchi KR, Ahmed MS, Johnston TP, Mitra AKBinding of Cosalane-A Novel Highly Lipophilic Anti-HIV Agent to Albumin and Glycoprotein, Journal of Pharmaceutical Sciences, 90(5), 659-666, 2001. 
  239. Gao H, Mitra AK. Regioselective Synthesis of Acyclovir and Its Various Prodrugs, Synthetic Communications, 31(9), 1399-1419, 2001.
  240. Yang C, Tirucherai GS, Mitra AK.Prodrug Based Optimal Drug Delivery via Membrane Transporter/receptor, Expert Opinion in Biotherapeutic Technologies, 1(2):159-175, 2001.
  241. Alur HH, Desai RP, Mitra AK, Johnston TP.  Inhibition of a Model Protease - Pyroglutamate Aminopeptidase by a Natural Oligosaccharide Gum from Hakea gibbosa, International Journal of Pharmaceutics, 212, 171-176, 2001.
  242. Yang C, Gao H, Mitra AK.  Chemical Stability, Enzymatic Hydrolysis, and Nasal Uptake of Amino Acid Ester Prodrugs of Acyclovir, Journal of Pharmaceutical Sciences, 90(5), 617-624, 2001. 
  243. Tirucherai GS, Yang C, Mitra AK.Prodrugs in Nasal Drug Delivery, Expert Opinion in Biotherapeutic Technologies, 1(1), 1471-1498- 2001. 
  244. Macha S, Mitra AK.  Ocular Pharmacokinetics in Rabbits Using a Novel Dual Probe Microdialysis Technique, Experimental Eye Research, 72, 289-299, 2001.
  245. Yang C, Mitra AK.  Nasal Absorption of Tyrosine Linked Model Compound, Journal of Pharmaceutical Sciences, 90(3):340-347, 2001.
  246. Mitra R, Pezron I, Li Y, Mitra AK.Enhanced Pulmonary Delivery of Insulin by Lung Lavage Fluid and Phospholipids, International Journal of Pharmaceutics, 217, 25-31, 2001. 
  247. Mitra R, Pezron I, Chu WI, Mitra AK.Lipid Emulsions as Vehicles for Enhanced Nasal Delivery of Insulin, International Journal of Pharmaceutics, 205, 127-134, 2000. 
  248. Tengamnuay P, Sahamethapat A, Sailasuta A, Mitra AK.  Chitosans as Nasal Absorption enhancers of Peptides: Comparison Between Free Amine Chitosans and Soluble Salts, International Journal of Pharmaceutics, 197, 53-67, 2000.
  249. Pal D, Udata C, Mitra AK.Transport of Cosalane - A Highly Lipophilic Novel Anti-HIV Agent - Across Caco-2 Cell Monolayers, Journal of Pharmaceutical Sciences, 89, 826-833, 2000.
  250. Dias C, Mitra AK.  Vitreal Elimination Kinetics of Large Molecular Weight FITC-Labeled Dextrans in Albino Rabbits Using a Novel Microsampling Technique, Journal of Pharmaceutical Sciences, 89(5), 572-578, 2000.
  251. Gao H, Mitra AK.  Synthesis of Acyclovir, Ganciclovir and Their Prodrugs - A Review, Synthesis, 3, 329-351, 2000.
  252. Gao H, Mitra AK.  Regioselective Synthesis of Various Prodrugs of Ganciclovir," Tetrahedron Letters, 41, 1131-1136, 2000.
  253. Kuchimanchi KR, Udata C, Johnston TP, Mitra AK.  Pharmacokinetics, Biliary Excretion, and Tissue Distribution of Novel Anti-HIV Agents, Cosalane and Dihydrocosalane, in Spraque-Dawley Rats, Drug Metabolism and Disposition, 28(4), 403-408, 2000.
  254. Hussain AM, Mitra AK.  Effect of Aging on Tryptophan Hydroxylase in Rat Brain: Implications on Serotonin Level, Drug Metabolism and Disposition, 28:9, 1038-1042, 2000.
  255. Chowdhury DK, Mitra AK.  Kinetics of a Model Nucleoside (Guanosine) Release from Biodegradable Poly (d,l-lactide-co-glycoslide) Microspheres: A Delivery System for Long-Term Intraocular Delivery, Pharmaceutical Development and Technology, 5(2), 276-285, 2000.
  256. Gao H, Mitra AK.  Spectral Data of Ester Prodrugs of Ganciclovir, Magnetic Resonance in Chemistry, 38:696-700, 2000.
  257. Alur HH, Johnston TP, Mitra AK.  Peptides and Proteins:  Buccal Absorption in Encyclopedia of Pharmaceutical Technology, First Edition, (Eds. James Swarbrick and James C. Boylan), Marcel Dekker, Inc., NY, 20:3, 193-218, 2000.
  258. Alur HH, Pather SI, Mitra AK, Johnston TP.  "Evaluation of the Gum from Hakeagibbosa as a Sustained-Release and Mucoadhesive Component in Buccal Tablets."  Pharmaceutical Development and Technology, 4(3), 347-358, 1999.
  259. Udata C, Tirucherai G, Mitra AK."Synthesis, Stereoselective Enzymatic Hydrolysis and Skin Permeation of Diastereomeric Propranolol Ester Prodrugs." Journal of Pharmaceutical Sciences, 88(5):544-550, 1999.
  260. Udata C, Mitra AK, Badr MZ.  Disposition of Cosalane, a Novel Anti-HIV Agent in Isolated Perfused Rat Liver, Drug Metabolism and Disposition, 27(8), 947-950, 1999.
  261. Alur HH, Pather SI, Mitra AK, Johnston TP.  Transbuccal Sustained-release of Chlorpheniramine Maleate in Rabbits Using a Novel, Natural Mucoadhesive Gum as an Excipient in Buccal Tablets., International Journal of Pharmaceutics, 188, 1-10, 1999.
  262. Chowdhury DK, Mitra AK.  Kinetics of In Vitro Release of a Model Nucleoside Deoxyuridine from Crosslinked Insoluble Collagen and Collagen-Gelatin Microspheres, International Journal of Pharmaceutics, 193, 113-122, 1999.
  263. Gao H, Mitra AK. NMR Spectral Data for Acyclovir Prodrugs.  Magnetic Resonance in Chemistry, 37:687-689, 1999.
  264. Johnston TP, Rahman A, AH Alur, HH, Mitra AK.  Enhanced Permeation of Unfolded Basic Fibroblast Growth Factor (bFGF) Across Rabbit Buccal Mucosa, Pharmaceutical Research, 15(2):250-257, 1998.
  265. Krishnamoorthy R, Mitra AK. Prodrugs for Nasal Drug Delivery.  Advanced Drug Delivery Reviews, 29:135-146, 1998.
  266. Shah D, Johnston TP, Mitra AK. The Effects of Various Excipients on the Unfolding of Basic Fibroblast Growth Factor, Journal of Pharmaceutical Sciences and Technology, 52(5), 209-214, 1998.
  267. Shah D, Johnston TP, Mitra AK. Thermodynamic Parameters Associated with Guamidine HCl - and Temperature-Induced Unfolding of bFGF, International Journal of Pharmaceutics, 169, 1-14, 1998.
  268. Johnston TP, Rahman A, Alur HH, Shah D, Mitra AK. Permeation of Unfolded Basic Fibroblast Growth Factor (bFGF) Across Rabbit Buccal Mucosa - Does Unfolding of bFGF Enhance Transport?  Pharmaceutical Research, 15(2), 246-253, 1998.
  269. Li Y, Mitra AK.  Effect of Phospholipid Chain Length, Concentration, Charge and Vesicle Size on Pulmonary Insulin Absorption, Pharmaceutical Research, 13 (1):76-79, 1996.
  270. Krishnamoorthy R, Mitra AK. Complexation of Weak Acids and Bases with Cyclodextrins:  Effects of Substrate Ionization on the Estimation and Interpretation of Association Constants, International Journal of Pharmaceutical Advances, 3 (1):329-343, 1996. 
  271. Shao Z, Mitra AK.  Pulmonary Delivery of Human Growth Hormone, European Journal of Pharmaceutics and Biopharmaceutics, 42 (3):199-203, 1996.
  272. Hughes PM, Krishnamoorthy R, Mitra AK.  Vitreous Disposition of Two Acycloguanosine Antivirals in the Albino and Pigmented Rabbit Models:  A Novel Ocular Microdialysis Technique, Journal of Ocular Pharmacology and Therapeutics.  12 (2):209,244, 1996.
  273. Krishnamoorthy R, Mitra AK.  Complexation of Weak Acids and Bases with Cyclodextrins:  Effects of Substrate Ionization on the Estimation and Interpretation of Association Constants, International Journal of Pharmaceutical Advances, 1(3):329-343, 1996.
  274. Krishnamoorthy R, Wolka AM, Shao Z, Mitra AK.  Cyclodextrins as Mucosal Absorption Promoters IV.  Evaluation of Nasal Mucotoxicity, European Journal of Pharmaceutics and Biopharmaceutics, 41(5):296-301, 1995.
  275. Pujara CP, Shao Z, Duncan MR, Mitra AK.  Effects of Formulation Variables on Nasal Epithelial Cell Integrity:  Biochemical Evaluation, International Journal of Pharmaceutics, 11, 197-203, 1995.
  276. Shao Z; Joffman AJ; Mitra AK. Biodegradation characteristics of acyclovir 2’-esters by respiratory carboxylesterases: Implications in prodrug design for intranasal and pulmonary drug delivery, Int. J. Pharm., 112:181-190, 1994.
  277. Fort JJ; Mitra AK. Development of a physical model for simultaneous diffusion/bioconversion of methotrexate dialkyl esters: A potential parallel/ sequential metabolic scheme, Inter J. Pharmaceu, 107:9-21, 1994.
  278. Scott-Moncrieff JC, Shao Z, Mitra AK.  Enhancement of Intestinal Insulin Absorption by Bile Salt-Fatty Acid Mixed Micelles in Dogs, Journal of Pharmaceutical Sciences, 83(10):1465-1469, 1994. 
  279. Fort JJ, Mitra AK.  Development of a Physical Model for Simultaneous Diffusion/Bioconversion of Methotrexate Dialkyl Esters:  Potential Parallel-Sequential Metabolic Scheme, International Journal of Pharmaceutics, 107, 9-21. 1994.
  280. Fort JJ, Mitra AK.  Effects of Epidermal/Dermal Separation Methods and Ester Chain Configuration on the Bioconversion of a Homologous Series of Methotrexate Dialkyl Esters in Dermal and Epidermal Homogenates of Hairless Mouse Skin, International Journal of Pharmaceutics, 102, 241-247, 1994.
  281. Shao Z, Mitra AK.  Bile Salt-Fatty Acid Mixed Micelles as Nasal Absorption Promoters.  III. Effects on Nasal Transport and Enzymatic Degradation of Acyclovir Prodrugs, Pharmaceutical Research, 11(2):243-249, 1994.
  282. Shao Z, Park Gee-Bae, Krishnamoorthy R, Mitra AK.  The Physicochemical Properties, Plasma Enzymatic Hydrolysis, and Nasal Absorption of Acyclovir and Its 2'-Ester Prodrugs, Pharmaceutical Research, 11(2):237-241, 1994.
  283. Fort JJ, Shao Z, Mitra AK.Transport of Methotrexate Dialkyl Ester Prodrugs Across Full-Thickness Hairless Mouse Skin, Drug Development and Industrial Pharmacy, 20(7):1213-1224, 1994.
  284. Li Y, Mitra AK.  A Simple Method of Correlating Pharmacodynamic Equivalence with Absolute Bioavailability Following Noninvasive Delivery of Insulin, Pharmaceutical Research, 11(10):1505-1507, 1994.
  285. Shao Z, Hoffman AJ, Mitra AK.  Biodegradation Characteristics or Acyclovir 2'-Esters by Respiratory Carboxylesterases:  Implications in Prodrug Design for Intranasal and Pulmonary Drug Delivery, International Journal of Pharmaceutics, 112, 181-190, 1994.
  286. Fort JJ, Mitra AK.  Effects of Epidermal/Dermal Separation Methods and Ester Chain Configuration on the Bioconversion of a Homologous Series of Methotrexate Dialkyl Esters in Dermal and Epidermal Homogenates of Hairless Mouse Skin, International Journal of Pharmaceutics, 102, 241-247, 1994.
  287. Shao Z, Li Y, Mitra AK.Cyclodextrins as Mucosal Absorption Promoters of Insulin III. Pulmonary Route of Delivery", European Journal of Pharmaceutics and Biopharmaceutics, 40(5):283-288, 1994.
  288. Shao Z, L, Y, Chermak T, Mitra AK.Cyclodextrins as Mucosal Absorption Promoters of Insulin II.  Effects of - Cyclodextrin Derivatives on  - Chymotryptic Degradation and Enteral Absorption of Insulin in Rats, Pharmaceutical Research, 11(8):1174-1179, 1994.
  289. Shao Z, Mitra AK.  Bile Salt-Fatty Acid Mixed Micelles as Nasal Absorption Promoters III.  Effects on Nasal Transport and Enzymatic Degradation of Acyclovir Prodrugs, Pharmaceutical Research, 11(2):243-250, 1994.
  290. Hughes PM, Mitra AK.  Effect of Acylation on the Ocular Disposition of Acyclovir II:  Corneal Permeability and Anti HSV-1 Activity of 2'-Esters in Rabbit Epithelial Keratitis.  Journal of Ocular Pharmacology, 9(4):299-309, 1993.
  291. Hughes PM, Krishnamoorthy R, Mitra AK.  Effect of Acylation on the Ocular Disposition of Acyclovir I:  Synthesis, Physiocochemical Properties, and Antiviral Activity of 2'-Esters.  Journal of Ocular Pharmacology, 9(4):287-297, 1993.
  292. Li Y, Shao Z, DeNicola DB, Mitra AK.Effect of a Conjugated Bile Salt on the Pulmonary Absorption of Insulin in Rats.  European Journal of Pharmaceutics and Biopharmaceutics, 39(5):216-221, 1993.
  293. Fort JJ, Shao Z, Mitra AK.Transport and Degradation Characteristics of Methotrexate Dialkyl Ester Prodrugs Acriss Tape-stripped Hairless Mouse Skin.  International Journal of Pharmaceutics, 100, 233-239, 1993.
  294. Li Y, Shao Z, Mitra AK.Chemical and  -Chymotrypsin-Mediated Proteolytic Degradation of Insulin in Bile Salt-Unsaturated Fatty Acid Mixed Micellar Systems.  Pharmaceutical Research; 10(11):1638-1641, 1993.
  295. Lovelace DS, Shao Z, Mitra AK.  Transport of L-Tryptophan Across the Rat Nasal Mucosa.  Journal of Pharmaceutical Sciences; 82(3):251-252, 1993.
  296. Liu FY, Shao Z, Kildsig DO, Mitra AK.  Pulmonary Delivery of Free and Liposomal Insulin.  Pharmaceutical Research, 10(2):228-232, 1993.
  297. Shao Z, Li YP, Krishnamoorthy R, Chermak T, Mitra AK.  Differential Effects of Anionic, Cationic, Non-ionic, and Physiologic Surfactants on the Dissociation, -Chymotryptic Degradation, and Intestinal Absorption of Insulin Hexamers, Pharmaceutical Research, 10(2):243-251, 1993.
  298. Choudhury S, Mitra AK.  Kinetics of Aspirin Hydrolysis and Stabilization in the Presence of 2-Hydroxy-Propyl--Cyclodextrin.  Pharmaceutical Research, 10(1):156-159, 1993.
  299. Li Y; Shao Z; Mitra AK. Dissociation of Insulin Oligomers by Bil Salt Micelles and Its Effect on α-Chymotrypsin-Mediated Proteolytic Degradation, Pharm Res 9(7): 864-869, 1992.
  300. Park GB, Mitra AK.  Mechanism and Site Dependency of Intestinal Mucosal Transport and Metabolism of Thymidine Analogues.  Pharmaceutical Research, 9(3):326-331, 1992.
  301. Liu FY, Kildsig DO, Mitra AK.  Pulmonary Biotransformation Insulin in Rat and Rabbit.  Life Sciences, 51(21):1683-1689, 1992.
  302. Schilling RJ, Mitra AK.  Pharmacodynamics of Insulin Following Intravenous and Enteral Administrations of Porcine-Zinc Insulin to Rats.  Pharmaceutical Research, 9(8):1003-1009, 1992.
  303. Ghosh MK, Mitra AK.  Brain Parenchymal Metabolism of 5-Iodo-2'-Deoxyuridine and 5'-Ester Prodrugs.  Pharmaceutical Research, 9(8):1052-1056, 1992.
  304. Park GB, Shao Z, Mitra AK.  Acyclovir Permeation Enhancement Across Intestinal and Nasal Mucosa by Bile Salt-Acyclarnitine Mixed Micelles.  Pharmaceutical Research, 9(10):1262-1267, 1992.
  305. Shao Z, Mitra AK.  Nasal Membrane and Intracellular Protein and Enzyme Release by Bile Salt-Fatty Acid Mixed Micelles - Correlation with Facilitated Drug Transport.  Pharmaceutical Research, 9(9):1184-1189, 1992.
  306. Shao Z, Krishnamoorthy R, Mitra AK.  Cyclodextrins as Nasal Absorption Promoters of Insulin - Mechanistic Evaluations.  Pharmaceutical Research, 9(9):1157-1163, 1992.
  307. Krishnamoorthy R, Mitra AK.  Kinetics and Mechanism of Degradation of a Cyclic Hexapeptide (Somatostatin Analogue) in Aqueous Solution.  Pharmaceutical Research, 9(10):1314-1320, 1992.
  308. Liu FY, Kildsig DO, Mitra AK.  Complexation of 6-Acyl-o--Cyclodextrin Derivatives with Steroids - Effects of Chain Length and Substitution Degree.  Drug Development and Industrial Pharmacy, 18(15):1599-1612, 1992.
  309. Ghosh MK, Mitra AK.  Enhanced Delivery of 5-Iodo-2'-Deoxyuridine to the Brain Parenchyma.  Pharmaceutical Research, 9(9):1173-1176, 1992.
  310. Liu FY, Kildsig DO, Mitra AK.  Cyclodextrin/Weak-Electrolyte Complexation:  Interpretation and Estimation of Association Constants from Phase Solubility Diagrams.  Pharmaceutical Research, 9(12):1671-1672, 1992.
  311. Schilling RJ, Mitra AK.  Degradation of Insulin by Trypsin and Alpha-chymotrypsin.  Pharmaceutical Research, 8(6):721-727, 1991.
  312. Ghosh MK, Mitra AK.  Effects of 5'-Ester Modification on the Physicochemical Properties and Plasma Protein Binding of 5-Iodo-2'-Deoxyuridine.  Pharmaceutical Research, 8(6):771-775, 1991.
  313. Liu FY, Kildsig DO, Mitra AK.  Insulin Aggregation in Aqueous Media:  Its Effect on Alphachymotrypsin Catalyzed Proteolytic Degradation.  Pharmaceutical Research, 8(7):925-929, 1991.
  314. Erb R, Abdallah A, Her L, Mitra AK.  Ocular Pharmacodynamics and Biophasic Drug Levels of Methionine Enkephalin.  Pharmaceutical Research, 8(7):930-932, 1991.
  315. Spancake CW, Kildsig DO, Mitra AK.  Thermorheologic Properties of Aqueous Solutions and Gels of Tetronic 1508.  Pharmaceutical Research, 8(3):245-249, 1991.
  316. Tengamnuay P, Shao Z, Mitra AK.  Systemic Absorption of L- and D-Phenyl Alanine Across Rat Nasal Mucosa.  Life Sciences, 48(15):1477-1481, 1991.
  317. Spancake C.W, Mitra AK. Kildsig, D.O.  Kinetics of Aspirin Hydrolysis in Aqueous Solutions and Gels of Poloxamines (Tetronic 1508) - Influence of Microenvironment.  International Journal of Pharmaceutics, 75, 231-239, 1991.
  318. Liu F-u; Kildsig DO; Mitra AK. Βeta-Cyclodextrin/Steroid Complexation: Effect of Steroid Structure on Association Equilibria, Pharm Res., 7(8):869-873, 1990.
  319. Basu K, Mitra AK.  Effects of 3-Hydrazone Modification on the Metabolism and Protein Binding of Progesterone.  International Journal of Pharmaceutics, 65, 109-114, 1990.
  320. Schilling RJ, Mitra AK.  Intestinal Mucosal Transport of Insulin.  International Journal of Pharmaceutics, 62, 53-64, 1990.
  321. Tengamnuay P, Mitra AK.  Bile Salt - Fatty Acid-Mixed Micelles as Nasal Absorption Promoters of Peptides I - Effects of Counterions, Adjuvant Composition of Lipid Structure on the Nasal Absorption of [D-Arj2]-Kyotorphin.  Pharmaceutical Research, 7(2):129-135, 1990.
  322. Ghosh MK, Mitra AK.  Carboxylic Ester Hydrolase Activity in Hairless and Athymic Mice Skin.  Pharmaceutical Research, 7(3):249-253, 1990.
  323. Tengamnuay P, Mitra AK.  Bile Salt - Fatty Acid-Mixed Micelles as Nasal Absorption Promotes as Peptides II - In Vivo Nasal Absorption of Insulin in Rats and Effects of Mixed Micelles on Morphological Integrity of Nasal Mucosa.  Pharmaceutical Research, 7(4):370-375, 1990.
  324. Fort JJ, Mitra AK.  Solubility and Stability Characteristics of a Series of Methotrexate Dialkyl Esters.  International Journal of Pharmaceutics, 58(1):1-9, 1990.
  325. Liu, FY, Kildsig DO, Mitra AK.  Beta-Cyclodextrin/Steroid Complexation:  Effect of Steroid Structure on Association Equilibria.  Pharmaceutical Research, 7(8):869-878, 1990.
  326. Narurkar MM, Mitra AK.  Prodrugs of 5-Iodo-2'-Deoxyuridine for Enhanced Ocular Transport.  Pharmaceutical Research, 6(10):888-892, 1989.
  327. Ghosh MK, Kildsig DO, Mitra AK.  Preparation and Characterization of Methotrexate-Immunoglobulin Conjugates.  Drug Design and Delivery, 4, 13-25, 1989.
  328. Tengamnuay P, Mitra AK.  Transport of Tyrosine and Phenylalanine Across the Rat Nasal Mucosa.  Life Sciences, 43(7):585-593, 1988.
  329. Mitra AK, Mikkelson TJ.  Mechanism of Transcorneal Permeation of Pilocarpine.  Journal of Pharmaceutical Sciences, 77(9):771-775, 1988.
  330. Narurkar MM, Mitra AK.  Synthesis, Physicochemical Properties and Cytotoxicity Studies of a Series of Novel 5'-Ester prodrugs of 5-Iodo-2'-Deoxyuridine.  Pharmaceutical Research, 5(11):734-737, 1988.
  331. Basu K, Kildsig DO, Mitra AK.  Synthesis and Kinetic Stability Studies of Progesterone Derivatives.  International Journal of Pharmaceutics, 47, 195-203, 1988.
  332. Fort JJ, Mitra AK.  Physical Chemical Properties and Chromatographic Behavior of a Homologous Series of Methotrexate ,   Dialkyl Ester Prodrugs.  International Journal of Pharmaceutics, 36, 7-16, 1987.
  333. Mitra AK, Mikkelson TJ.  Ophthalmic Solutions Buffer Systems II - Effect of Buffer Type and Concentration on the Ocular Absorption of Pilocarpine and a method of Ocular Bioavailability Prediction from Physicochemical Data.  International Journal of Pharmaceutics, 37, 19-26, 1987.
  334. Mitra AK, Narurkar M.  Kinetics of Azathioprine Degradation in Aqueous Solution.  International Journal of Pharmaceutics, 35, 165-171, 1987.
  335. Mitra AK, Mailloux AT.  Mitomycin C Pharmacokinetics in Rats - Effect of Dose Size.  International Journal of Pharmaceutics, 32, 133-141, 1986.
  336. Mitra AK, Narurkar MM.  Effect of Mercaptan Nucleophiles on the Degradation of Azathioprine in Aqueous Solution.  International Journal of Pharmaceutics, 28, 119-126, 1986.
  337. Mitra AK. Gastrointestinal Absorption of Peptides and Proteins.  Pharmacy International, 7(12):323-326, 1986.
  338. Mitra AK, Matthews M L.  Effects of pH and Phosphate on the Oxidation of Iron in Aqueous Solution.  International Journal of Pharmaceutics, 23, 185-193, 1985.
  339. Mitra AK, Narurkar MM.  Solvent Effects on Fluorescence Properties of Sodium-Lasalocid (Ionophore X-537A).  Journal of Organic Chemistry, 49, 1293-1295, 1984.
  340. Mitra AK, Mikkelson TJ.  Ophthalmic Solution Buffer Systems I.  The Effect of Buffer Concentration on the Ocular Absorption of Pilocarpine.  International Journal of Pharmaceutics, 10, 219-229, 1982.
  341. Mitra AK, Baustian CL, Mikkelson TJ.  High Performance Liquid Chromatographic Determination of Pilocarpine in Aqueous Humor:  Derivatization by Quaternization of the Methylimidazole Tertitary Amine Group.  Journal of Pharmaceutical Sciences, 69, 257-261, 1980.

 

 

 

 

 

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