Education

Biography

Professor Akira Sugawara belongs to the Department of Molecular Endocrinology, Tohoku University Graduate School of Medicine, Sendai, Japan. He graduated from Tohoku University School of Medicine on 1987 (M.D.), and got Ph.D. on 1991 from Tohoku University Graduate School of Medicine. He performed Postdoctoral Fellowship in William Chin’s laboratory at the Women’s Hospital/Harvard Medical School in Boston from 1991 to 1994. His major is general internal medicine, endocrinology and metabolism and hypertension and nephrology. His research interest is 1) molecular biology of nuclear hormone receptors, 2) etiology of high blood pressure, 3) pathophysiology of diabetic nephropathy, 4) gene regulation of aldosterone synthase, and 5) epigenetics of hypertension and diabetes mellitus.

Research Interest

Endocrinology and Metabolism, Vascular Biology

Scientific Activities

Academic Appointments

Professional Societies

Awards

Publications

1. Sasaki A, Sato S, Shinkawa O, Go M, Otsuka T, Sugawara A, Shimizu Y, Murakami O, Hanew K, Andoh N, Sasano N, Yoshinaga K. Peptide histidine methionine may be a prolactin-releasing hormone in humans. J Clin Endocrinol Metab. 1988; 66: 1202-1207.
2. Hanew K, Sato S, Goh M, Sasaki A, Shimizu Y, Sugawara A, Otsuka T, Yoshinaga K. The spectrum of GH responses to GHRH and somatostatin in patients with acromegaly. Tohoku J Exp Med. 1988; 155: 233-239.
3. Hanew K, Sugawara A, Shimizu Y, Sato S, Sasaki A, Tazawa S, Ishii K, Saitoh T, Saso S, Yoshinaga K. The combination therapy with bromocriptine and cyproheptadine in patients with acromegaly. Endocrinol Jpn. 1989; 36: 429-438.
4. Sugawara A, Nata K, Inoue C, Takasawa S, Yamamoto H, Okamoto H. Nucleotide sequence determination of mouse, chicken and Xenopus laevis rig cDNAs: the rig-encoded protein is extremely conserved during vertebrate evolution. Biochem Biophys Res Commun. 1990; 166: 1501-1507.
5. Hanew K, Sugawara A, Utsumi A, Shimizu Y, Yoshinaga K. GHRH and TRH tests in patients with idiopathicand secondary GH deficiency -with special reference to GH response patterns to GHRH-. Tohoku J Exp Med. 1990; 160: 189-202.
6. Hanew K, Utsumi A, Sugawara A, Shimizu Y, Yoshinaga K. Evidence for dopamine-related pituitary TSH and PRL pools in patients with prolactinoma. Acta Endocrinol (Copenh). 1991; 124: 545-552.
7. Sugawara A, Shiga K, Takasawa S, Yonekura H, Yamamoto H, Okamoto H. Sequence of the chicken rig/ribosomal protein S15 gene. Gene. 1991; 108: 313-314.
8. Hanew K, Utsumi A, Sugawara A, Shimizu Y, Tazawa S, Yoshinaga K. The relation between pituitary magnetic resonance imaging findings and GH, TSH, PRL dynamics in patients with idiopathic GH deficiency. Acta Endocrinol (Copenh). 1991; 125: 342-347.
9. Utsumi A, Hanew K, Sugawara A, Shimizu Y, Murakami O, Ikeda H, Yoshinaga K. Plasma growth hormone (GH) responses to corticotropin-releasing hormone in patients with acromegaly -the effect of dexamethasone pretreatment and the comparison with GH responses to thyrotropin-releasing hormone, gonadotropin-releasing hormone, and GH-releasing hormone. J Endocrinol Invest. 1992; 15: 167-171.
10. Hanew K, Utsumi A, Sugawara A, Shimizu Y, Yoshinaga K. Simultaneous administration of TRH and sulpiride caused additive but not synergistic PRL responses in normal subjects. Endocrinol Jpn. 1992; 39: 465-468.
11. Yen PM, Sugawara A, Refetoff S, Chin WW. New insights on the mechanism(s) of the dominant negative effect of mutant thyroid hormone receptor in generalized resistance to thyroid hormone (GRTH). J Clin Invest. 1992; 90: 1825-1831.
12. Yen PM, Sugawara A, Chin WW. Triiodothyronine (T3) differentially decreases T3-receptor/retinoic acid receptor and T3-receptor/retinoid X receptor heterodimer binding to DNA. J Biol Chem. 1992; 267: 23248-23252.
13. Hanew K, Utsumi A, Sugawara A, Shimizu Y, Tazawa S, Abe K. Plasma GH responses to the sequential 3 day administrations of GHRH followed by arginine infusion in patients with idiopathic GH deficiency and normal short children. Tohoku J Exp Med. 1993; 169: 91-101.
14. Sugawara A, Yen PM, Darling DS, Chin WW. Characterization and tissue expression of multiple triiodothyronine (T3) receptor-auxiliary proteins (TRAPs), and their relationship to the retinoid X receptors (RXRs). Endocrinology. 1993; 133: 965-971.
15. Yen PM, Sugawara A, Forgione M, Spanjaard RA, Macchia E, Cheng S-Y, Chin WW. Region-specific anti-thyroid hormone receptor (TR) antibodies detect changes in TR structure due to ligand-binding and dimerization. Mol Cell Endocrinol. 1993; 97: 93-99.
16. Yen PM, Spanjaard RA, Sugawara A, Darling DS, Nguyen VP, Chin WW. Orientation and spacing of half-sites differentially affect T3-receptor (TR) monomer, homodimer, and heterodimer binding to thyroid hormoneresponse elements (TREs). Endocrine J. 1993; 1: 461-466.
17. Sugawara A, Yen PM, Apriletti JW, Ribeiro RC, Sacks DB, Baxter JD, Chin WW. Phosphorylation selectively increases triiodothyronine (T3)-receptor homodimer binding to DNA. J Biol Chem. 1994; 269: 433-437.
18. Yen PM, Ikeda M, Brubaker JH, Forgione M, Sugawara A, Chin WW. Roles of v-erbA homodimers and heterodimers in mediating dominant negative activity by v-erbA. J Biol Chem. 1994; 269: 903-909.
19. Yen PM, Ikeda M, Wilcox EC, Brubaker J, Spanjaard RA, Sugawara A, Chin WW. Half-site arrangement of hybrid glucocorticoid and thyroid hormone response elements specifies thyroid hormone receptor complex binding to DNA and transcriptional activity. J Biol Chem. 1994; 269: 12704-12709.
20. Hanew K, Utsumi A, Sugawara A, Shimizu Y, Abe K. Enhanced GH responses to combined administration of GHRP and GHRH in patients with acromegaly. J Clin Endocrinol Metab. 1994; 78: 509-512.
21. Hanew K, Utsumi A, Sugawara A, Shimizu Y, Ikeda H, Abe K. The evaluation of hypothalamic somatostatintone using pyridostigmine and thyrotropin releasing hormone in patients with acromegaly. J Endocrinol Invest. 1994; 17: 313-321.
22. Sugawara A, Yen PM, Chin WW. 9-cis retinoic acid regulation of rat growth hormone gene expression: potential roles of multiple nuclear hormone receptors. Endocrinology. 1994; 135: 1956-1962.
23. Hanew K, Utsumi A, Sugawara A, Tanaka A, Fukazawa H, Yoshida K, Abe K. Enhanced plasma GH responses to simultaneous administration of TRH and GHRH in patients with primary hypothyroidism. Endocrine J. 1995; 42: 43-47.
24. Sugawara A, Yen PM, Qi Y, Lechan RM, Chin WW. Isoform-specific retinoid-X receptor (RXR) antibodies detect differential expression of RXR proteins in the pituitary gland. Endocrinology. 1995; 136: 1766-1774.
25. Spanjaard RA, Sugawara A, Ikeda M, Chin WW. Evidence that retinoid X receptors mediate retinoid-dependent transcriptional activation of the retinoic acid receptor β gene in S91 melanoma cells. J Biol Chem. 1995; 270: 17429-17436.
26. Yen PM, Sugawara A, Liu Y, Whang J, Chin WW. Factors that enhance E. coli expressed TRβ binding to T3 and DNA. Thyroid. 1995; 5: 309-313.
27. Hanew K, Tanaka A, Utsumi A, Sugawara A, Abe K. Plasma GH responses to human GHRH-agonist in normal subjects. Eur J Endocrinol. 1996; 134: 67-72.
28. Yen PM, Liu Y, Sugawara A, Chin WW. Vitamin D receptors repress basal transcription and exert dominant negative activity on triiodothyronine-mediated transcriptional activity. J Biol Chem. 1996; 271: 10910-10916.
29. Hanew K, Tanaka A, Utsumi A, Sugawara A, Abe K. The inhibitory effects of growth hormone-releasing hormone (GHRH)-antagonist on GHRH, L-dopa, and clonidine-induced GH secretion in normal subjects. J Clin Endocrinol Metab. 1996; 81: 1952-1955.
30. Takahashi N, Takeuchi K, Abe T, Sugawara A, Abe K. Immunolocalization of rat thromboxane receptor in the kidney. Endocrinology. 1996; 137: 5170-5173.
31. Hanew K, Tanaka A, Sugawara A, Itoi K, Abe K. Plasma GH, TSH, and PRL responses to recombinant humaninsulin-like growth factor-I (IGF-I) in normal and acromegalic subjects. Endocrine J. 1996; 43 Suppl.: S81-S83.
32. Sanno N, Sugawara A, Teramoto A, Abe Y, Yen PM, Chin WW, Osamura RY. Immunohistochemical expression of retinoid-X receptor (RXR) isoforms in human pituitaries and pituitary adenomas. Neuroendocrinology. 1997; 65: 299-306.
33. Sugawara A, Sanno N, Takahashi N, Osamura RY, Abe K. Retinoid X receptors (RXRs) in the kidney: their protein expression and functional significance. Endocrinology. 1997; 138: 3175-3180.
34. Takahashi N, Takeuchi K, Sugawara A, Taniyama Y, Kato T, Wilcox CS, Abe K, Ito S. Structure and transcriptional function of the 5'-flanking region of rat thromboxane receptor gene. Biochem Biophys Res Commun. 1998; 244: 489-493.
35. Sugawara A, Uruno A, Nagata T, Taketo MM, Takeuchi K, Ito S. Characterization of mouse retinoid X receptor (RXR)-β gene promoter: negative regulation by tumor necrosis factor (TNF)-α. Endocrinology. 1998; 139: 3030-3033.
36. Imaizumi M, Suzuki H, Yoshinari M, Sato A, Saito T, Sugawara A, Tsuchiya S, Hatae Y, Fujimoto T, Kakizuka A, Konno T, Iinuma K. Mutations in the E-domain of RARα portion of the PML/RARα chimeric gene may confer clinical resistance to all-trans retinoic acid in acute promyelocytic leukemia. Blood. 1998; 92:374-382.
37. Sugawara A, Hanew K, Ogawa M, Kamijo T, Tanaka A, Itoi K, Igarashi Y, Iwatani N, Kohno H, Koga J, Ito S. A Case of Inherited GH Deficiency with a 6.7-kb Deletion of GH-1 Gene. Clin Pediatr Endocrinol. 1998; 7: 41-46.
38. Sanno N, Sugawara A, Tahara S, Osamura RY, Teramoto A. Retinoid X receptors (RXRs) mRNA expression in human pituitary adenomas. Endocrine Pathology. 1999; 10: 73-83.
39. Duncan KG, Jumper MD, Ribeiro RC, Bailey KR, Yen PM, Sugawara A, Patel A, Stern R, Chin WW, Baxter JD, Schwartz DM. Human trabecular meshwork cells as a thyroid hormone target tissue: presence of functionalthyroid hormone receptors. Graefes Arch Clin Exp Ophthalmol. 1999; 237: 231-240.
40. Ikeda Y, Takeuchi K, Kato T, Taniyama Y, Sato K, Takahashi N, Sugawara A, Ito S. Transcriptional suppression of rat angiotensin AT1a receptor gene expression by interferon-γ in vascular smooth muscle cells. Biochem Biophys Res Commun. 1999; 262: 494-498.
41. Ikeda Y, Sugawara A, Taniyama Y, Uruno A, Igarashi K, Arima S, Ito S, Takeuchi K. Suppression of rat thromboxane synthase gene transcription by peroxiosme proliferator-activated receptor γ in macrophagesvia an interaction with NF-E2 related factor 2. J Biol Chem. 2000; 275: 33142-33150.
42. Suzuki T, Moriya T, Sugawara A, Ariga N, Takabayashi H, Sasano H. Retinoid receptors in human breastcarcinoma: possible modulators of in situ estrogen metabolism. Br Cancer Res Treat. 2001; 65: 31-40.
43. Sugawara A, Takeuchi K, Uruno A, Ikeda Y, Arima S, Sato K, Kudo M, Taniyama Y, Ito S. Differential effects among thiazolidinediones on the transcription of thromboxane receptor and angiotensin II type 1 receptor genes. Hypertens Res. 2001; 24: 229-233.
44. Ito K, Suzuki T, Moriya T, Utsunomiya H, Sugawara A, Konno R, Sato S, Sasano H. Retinoid receptors in the human endometrium and its disorders: a possible modulator of 17β-hydroxysteroid dehydrogenase. J Clin Endocrinol Metab. 2001; 86: 2721-2727.
45. Sugawara A, Takeuchi K, Uruno A, Ikeda Y, Arima S, Kudo M, Sato K, Taniyama Y, Ito S. Transcriptional suppression of type-1 angiotensin II receptor gene expression by peroxisome proliferator-activated receptor-γ in vascular smooth muscle cells. Endocrinology. 2001; 142: 3125-3134.
46. Taniyama Y, Sato K, Sugawara A, Uruno A, Ikeda Y, Kudo M, Ito S, Takeuchi K. Renal tubule-specific transcription and chromosomal localization of rat thiazide-sensitive Na-Cl cotransporter gene. J Biol Chem. 2001; 276: 26260-26268.
47. Arima S, Kohagura K, Takeuchi K, Taniyama Y, Sugawara A, Ikeda Y, Abe M, Omata K, Ito S. Biphasic vasodilator action of troglitazone on the renal microcirculation. J Am Soc Nephrol. 2002; 13: 342-349.
48. Sugawara A, Uruno A, Ikeda Y, Kudo M, Sato K, Taniyama Y, Ito S, Takeuchi K. Transcription suppression of thromboxane receptor gene by peroxisome proliferator-activated receptor-γ via an interaction with Sp1 in vascular smooth muscle cells. J Biol Chem. 2002; 277: 9676-9683.
49. Kawamura T, Yoshida K, Sugawara A, Nagasaka M, Mori N, Takeuchi K, Kohzuki M.　Impact of exercise and angiotensin converting enzyme inhibition on tumor necrosis factor-alpha and leptin in fructose-fed hypertensive rats. Hypertens Res. 2002; 25: 919-926.
50. Sugawara T, Sato M, Itoi K, Sugawara A, Matsuda Y, Shimada K, Sado T, Wu S, Kondo T. Successful localization and treatment for ectopic adrenocorticotrophic hormone secretion in a rare case of possible Tx N2 M0 carcinoid tumor with Cushing syndrome. J Thorac Cardiovasc Surg. 2002; 124: 1237-1238.
51. Sugawara A, Takeuchi K, Uruno A, Kudo M, Sato K, Ito S. Effects of MAP kinase pathway and co-activator CBP on peroxisome proliferator-activated receptor-γ-mediated transcription suppression of angiotensin II type 1 receptor gene. Hypertens Res. 2003; 26: 623-628.
52. Uruno A, Sugawara A, Kudo M, Sato M, Sato K, Ito S, Takeuchi K. Transcription suppression of thromboxane receptor gene expression by retinoids in vascular smooth muscle cells. Hypertens Res. 2003; 26: 815-821.
53. Arima S, Kohagura K, Xu H-L, Sugawara A, Abe T, Satoh F, Takeuchi K, Ito S. Nongenomic vascular action of aldosterone in the glomerular microcirculation. J Am Soc Nephrol. 2003; 14: 2255-2263.
54. Sugawara A, Takeuchi K, Suzuki T, Itoi K, Sasano H, Ito S. A case of aldosterone-producing adrenocortical adenoma associated with a probable post-operative adrenal crisis: histopathological analyses of the adrenal gland. Hypertens Res. 2003; 26: 663-668.
55. Arima S, Kohagura K, Xu HL, Sugawara A, Uruno A, Satoh F, Takeuchi K, Ito S: Endothelium-derived nitric oxide modulates vascular action of aldosterone in renal arteriole. Hypertension. 2004; 43: 352-357.
56. Kawamura T, Yoshida K, Sugawara A, Nagasaka M, Mori N, Takeuchi K, Kohzuki M.　Regulation of skeletal muscle peroxisome proliferator-activated receptor γ expression by exercise and angiotensin-converting enzyme inhibition in fructose-fed hypertensive rats. Hypertens Res. 2004; 27: 61-70.
57. Sato K, Sugawara A, Kudo M, Uruno A, Ito S, Takeuchi K. Expression of peroxisome proliferator-activated receptor isoform proteins in the rat kidney. Hypertens Res. 2004; 27: 417-425.
58. Lee Y-M, Fujiwara J, Munakata Y, Ishii T, Sugawara A, Kaku M, Kokubun S, Sasaki T, Funato T: A mutation of the glucocorticoid receptor gene in patients with systemic lupus erythematosus. Tohoku J Exp Med. 2004; 203: 69-76.
59. Kudo M, Sugawara A, Uruno A, Takeuchi K, Ito S: Transcription suppression of peroxisome proliferator-activated receptor γ2 gene expression by tumor necrosis factor α via an inhibition of CCAAT/enhancer-binding protein δ during the early stage of adipocyte differentiation. Endocrinology. 2004; 145: 4948-4956.
60. Takiyama Y, Miyokawa N, Sugawara A, Kato S, Ito K, Sato K, Oikawa K, Kobayashi H, Kimura S, Tateno M: Decreased expression of retinoid X receptor (RXR) isoforms in human thyroid carcinomas. J Clin Endocrinol Metab. 2004; 89: 5851-5861.
61. Uruno A, Sugawara A, Kanatsuka H, Arima S, Taniyama Y, Kudo M, Takeuchi K, Ito S. HGF stimulates NO production through eNOS phosphorylation by PI3K and MAPK pathways. Hypertens Res. 2004; 27: 887-895.
62. Sato M, Sugawara A, Egawa N, Yajima Y, Kato H, Kagechika H: Nobel RXR antagonists enhance transactivation of PPARg and ST 13 preadipocyte differentiation. 12th Internatinal Congress of Endocrinology International Proceedings. 2004; 547-551.
63. Hongo M, Kanatsuka H, Sugawara A, Nagasaki Y, Endo Y, Karahashi K, Shoji T, Sagami Y, Aoki I. Primary care in the treatment of functional gastrointestinal symptoms in Japan: prescription preferences and impression of results. Aliment Pharmacol Ther. 2005; 21 Suppl 2: 47-54.
64. Chung BH, Li C, Sun BK, Lim SW, Ahn KO, Yang JH, Choi YH, Yoon KH, Sugawara A, Ito S, Kim J, Yang CW: Rosiglitazone protects against cyclosporine-induced pancreatic and renal injury in rats. Am J Transplant. 2005; 5: 1856-1867.
65. Uruno A, Sugawara A, Kanatsuka H, Kagechika H, Saito A, Sato K, Kudo M, Takeuchi K, Ito S: Up-regulation of nitric oxide production in vascular endothelial cells by all-trans retinoic acid through thephosphoinositide 3-kinase/Akt pathway. Circulation. 2005; 112: 727-736.
66. Chung BH, Lim SW, Ahn KO, Sugawara A, Ito S, Choi BS, Kim YS, Bang BK, Yang CW: Protective effects of peroxisome proliferators activated receptor gamma agonists on diabetic and non-diabetic renal diseases. Nephrology. 2005; 10: S40-S43.
67. Park CW, Kim HW, Ko SH, Chung HW, Lim SW, Yang CW, Chang YS, Sugawara A, Guan Y, Breyer MD: Accelerated diabetic nephropathy in mice lacking the peroxisome proliferator-activated receptor {alpha}. Diabetes. 2006; 55: 885-893.
68. Suzuki T, Hayashi S, Miki Y, Ono K, Nakamura Y, Moriya T, Sugawara A, Ishida T, Ohuchi N, Sasano H: Peroxisome proliferator-activated receptorγ(PPARγ) in human breast carcinoma: a possible modulator of estrogenic actions. Endocr Relat Cancer. 2006; 13: 233-250.
69. Hoshi K, Kawakami J, Sato W, Sato K, Sugawara A, Saito Y, Yoshida K: Assisting the diagnosis of thyroid disease with a neural network making use of routine test data: identification of highly suspected patients with hyperthyroidism. Chem Pharm Bull. 2006; 54: 1162-1169.
70. Saito A, Sugawara A, Uruno A, Kudo M, Kagechika H, Sato Y, Owada Y, Kondo H, Sato M, Kurabayashi M, Imaizumi M, Tsuchiya S, Ito S. All-trans retinoic acid induces in vitro angiogenesis via retinoic acid receptor: possible involvement of endogenous vascular endothelial growth factor signaling. Endocrinology. 2007; 148: 1412-1423.
71. Ahn KO, Lim SW, Yang HJ, Li C, Sugawara A, Ito S, Choi BS, Kim YS, Kim J, Yang CW. Induction of PPARgamma mRNA and protein expression by rosiglitazone in chronic cyclosporine nephropathy in the rat. Yonsei Med J. 2007; 48: 308-316.
72. Obara W, Konda R, Akasaka S, Nakamura S, Sugawara A, Fujioka T. Prognostic significance of vitamin Dreceptor and retinoid X receptor expression in renal cell carcinoma. J Urol. 2007; 178: 1497-1503.
73. Suzuki K, Awata S, Oyama Y, Fujiyama M, Takano T, Sugawara A, Matsuoka H. Agitated depression successfully treated with electroconvulsive therapy combined with steroid cover in a patient with Addison's disease. Prog Neuropsychopharmacol Biol Psychiatry. 2007; 31: 956-958.
74. Noguchi N, Yoshikawa T, Ikeda T, Takahashi I, Shervani NJ, Uruno A, Yamauchi A, Nata K, Takasawa S, Okamoto H, Sugawara A. FKBP12.6 disruption impairs glucose-induced insulin secretion. Biochem Biophys Res Commun. 2008; 371: 735-740.
75. Bluth M, Mueller CM, Pierre J, Callender G, Kandil E, Viterbo D, Fu SL, Sugawara A, Okamoto H, Zenilman ME. Pancreatic reg I in chronic pancreatitis and aging: implications for new therapeutic approaches to diabetes. Pancreas. 2008: 37: 386-395.
76. Uruno A, Sugawara A, Kudo M, Satoh F, Saito A, Ito S. Stimulatory effects of low-dose HMG-CoA reductase inhibitor fluvastatin on hepatocyte growth factor-induced angiogenesis: involvement of p38 mitogen-activated protein kinase. Hypertens Res. 2008; 31: 2085-2096.
77. Yamauchi A, Takahashi I, Takasawa S, Nata K, Noguchi N, Ikeda T, Yoshikawa T, Shervani NJ, Suzuki I, Uruno A, Unno M, Okamoto H, Sugawara A. Thiazolidinediones inhibit REG Iα gene transcription in gastrointestinal cancer cells. Biochem Biophys Res Commun. 2009; 379: 743-748.
78. Takahashi I, Noguchi N, Nata K, Yamada S, Kaneiwa T, Mizumoto S, Ikeda T, Sugihara K, Asano M, Yoshikawa T, Yamauchi A, Shervani NJ, Uruno A, Kato I, Unno M, Sugahara K, Takasawa S, Okamoto H, Sugawara A. Important role of heparan sulfate in the morphogenesis, ß-cell proliferation, and insulin secretion of mouse pancreatic islets. Biochem Biophys Res Commun. 2009; 383: 113-118.
79. Nakamura Y, Suzuki T, Sugawara A, Arai Y, Sasano H. Peroxisome proliferator-activated receptor gamma (PPARγ) in human prostate carcinoma. Pathol Int. 2009; 59: 288-293.
80. Kaur S, Kumar TR, Uruno A, Sugawara A, Jayakumar K, Kartha CC. Genetic engineering with endothelial nitric oxide synthase improves functional properties of endothelial progenitor cells from patients with coronary artery disease: an in vitro study. Basic Res Cardiol. 2009; 104: 739-749.
81. Sato W, Hoshi K, Kawakami J, Sato K, Sugawara A, Saito Y, Yoshida K. Assisting the diagnosis of Graves’ hyperthyroidism with Bayesian-type and SOM-type neural networks by making use of a set of three routine tests and their correlation with free T4. Biomed Pharmacother. 2010; 64: 7-15.
82. Zhou L, Zhang R, Wang L, Shen S, Okamoto H, Sugawara A, Xia L, Wang X, Noguchi N, Yoshikawa T, Uruno A, Yao W, Yuan Y. Up-regulation of REG Iα accelerates tumor progression in pancreatic cancer with diabetes. Int J Cancer. 2010; 127: 1795-1803.
83. Sugawara A, Kudo M, Saito A, Matsuda K, Uruno A, Ito S. Novel effects of beraprost sodium on vasculatures.Int Angiol. 2010; 29(2 Suppl): 28-32.
84. Sugawara A, Uruno A, Kudo M, Matsuda K, Yang CW, Ito S. Effects of PPARγ on hypertension, atherosclerosis, and chronic kidney disease. Endocrine J. 2010; 57: 847-852.
85. Aoki S, Hoshi K, Kawakami J, Sato K, Satoh K, Mori K, Sugawara A, Saito Y, Yoshida K. Assisting the diagnosis of Graves’ hyperthyroidism with pattern recognition methods and a set of three routine tests parameters, and their correlations with free T4 levels: extension to male patients. Biomed Pharmacother. 2011; 65: 95-104.
86. Uruno A, Matsuda K, Noguchi N, Yoshikawa T, Kudo M, Satoh F, Rainey WE, Hui XG, Akahira JI, Nakamura Y, Sasano H, Okamoto H, Ito S, Sugawara A. Peroxisome proliferator-activated receptor-γ suppresses CYP11B2expression and aldosterone production. J Mol Endocrinol. 2011; 46: 37-49.
87. Zheng HC, Sugawara A, Okamoto H, Takasawa S, Takahashi H, Masuda S, Takano Y. Expression profile of the REG gene family in colorectal carcinoma. J Histochem Cytochem. 2011; 59: 106-115.
88. Uruno A, Noguchi N, Matsuda K, Nata K, Yoshikawa T, Chikamatsu Y, Kagechika H, Harigae H, Ito S, Okamoto H, Sugawara A. All-trans retinoic acid and a novel synthetic retinoid tamibarotene (Am80) differentially regulate CD38 expression in human leukemia HL-60 cells: possible involvement of protein kinase C-{delta}. J Leukoc Biol. 2011; 90: 235-247.
89. Peterson KM, Guo X, Elkahloun AG, Mondal D, Bardhan PK, Sugawara A, Duggal P, Haque R, Petri WA Jr. The expression of REG 1A and REG 1B is increased during acute amebic colitis. Parasitol Int. 2011; 60: 296-300.
90. Fujishima F, Suzuki T, Nakamura Y, Taniyama Y, Ono K, Sugawara A, Miyazaki S, Moriya T, Sato A, Satomi S, Sasano H. Retinoid receptors in human esophageal squamous cell carcinoma: Retinoid X receptor as a potent prognostic factor. Pathol Int. 2011; 61: 401-408.
91. Kaur S, Harikrishnan VS, Shenoy SJ, Radhakrishna NS, Uruno A, Sugawara A, Kartha CC. Transfection of endothelial nitric oxide synthase gene improves angiogenic efficacy of endothelial progenitor cells in rabbits with hindlimb ischemia. J Clinic Experiment Cardiol. 2011; 2:140. doi: 10.4172/2155-9880.1000140
92. Sugawara A, Uruno A, Kudo M, Matsuda K, Yang CW, Ito S. PPARγ agonist beyond glucose lowering effect. Korean J Intern Med. 2011; 26: 19-24.
93. Hoshi Y, Imaizumi M, Sato A, Rikiishi T, Sugawara A, Kizaki M, Tsuchiya S. UF-1, a human acute promyelocytic leukemia cell line carrying the mutant PML-RAR, exhibits different maturation pattern in response to ATRA or Am80, a RAR-selective synthetic retinoid. Jpn J Pediatr Hematol Oncol. 2012; 49: 24-30.
94. Aoki S, Hoshi K, Kawakami J, Sato K, Sato W, Satoh H, Mori K, Sugawara A, Nakagawa Y, Yoshida K. Assisting the diagnosis of overt hypothyroidism with pattern recognition methods making use of a set of routine tests, and their multiple correlation with total T4. Biomed Pharmacother. 2012; 66: 195-205.
95. Ikeda T, Takasawa S, Noguchi N, Nata K, Yamauchi A, Takahashi I, Yoshikawa T, Sugawara A, Yonekura H, Okamoto H. Identification of a major enzyme for the synthesis and hydrolysis of cyclic ADP-ribose in amphibian cells and evolutional conservation of the enzyme from human to invertebrate. Mol Cell Biochem. 2012; 366: 69-80.
96. Sugawara A, Uruno A, Matsuda K, Saito-Ito T, Funato T, Saito-Hakoda A, Kudo M, Ito S. Effects of PPARγ agonists against vascular and renal dysfunction. Curr Mol Pharmacol. 2012; 5: 248-254.
97. Sugawara A, Sato H, Ito S. Diabetes and hepatitis C infection in dialysis patients: the present situation in Japan. Nephro-Urol Mon. 2012; 4: 391-392.
98. Saha HR, Khan H, Sarkar BC, Khan SA, Sana NK, Sugawara A, Choudhury S. Effects of thyroid dysfunction on lipid profile with and without diabetes subjects. OJEMD. 2013; 3: 113-119.
99. Uruno A, Furusawa Y, Yagishita Y, Fukutomi T, Muramatsu H, Negishi T, Sugawara A, Kensler TW, Yamamoto M. The keap1-nrf2 system prevents onset of diabetes mellitus. Mol Cell Biol. 2013; 33: 2996-3010.
100. Kudo M, Saito-Hakoda A, Matsuda K, Shimizu K, Sato I, Uruno A, Yoshikawa T, Iki Y, Sugawara K, Kogure N, Saito-Ito T, Ito S, Sugawara A. The effects of GLP-1 receptor agonists on endothelial function: do they function directly or indirectly? J Autacoids. 2013; 2: e121.
101. Nakamura T, Yoshikawa T, Noguchi N, Sugawara A, Kasajima A, Sasano H, Yanai K. The expression and function of histamine H3 receptor in pancreatic β-cells. Br J Pharmacol. 2014; 171: 171-185.
102. Yagishita Y, Fukutomi T, Sugawara A, Kawamura H, Takahashi T, Pi J, Uruno A, Yamamoto M. Nrf2 protects pancreatic β-cells from oxidative and nitrosative stress in diabetic model mice. Diabetes. 2014; 63: 605-618.
103. Ito R, Katsura S, Shimada H, Tsuchiya H, Hada M, Okumura T, Sugawara A, Yokoyama A. TET3-OGT interaction increases the stability and the presence of OGT in chromatin. Genes Cells. 2014; 19: 52-65.
104. Matsuda K, Uruno A, Kogure N, Sugawara K, Shimada H, Nezu M, Saito-Ito T, Iki Y, Kudo M, Shimizu K, Sato I, Yoshikawa T, Satoh F, Ito R, Yokoyama A, Rainey WE, Saito-Hakoda A, Ito S, Sugawara A. Angiotensin II receptor blockers differentially affect CYP11B2 expression in human adrenal H295R cells. Mol Cell Endocrinol. 2014; 383: 60-68.
105. Felizola SJ, Nakamura Y, Ono Y, Kitamura K, Kikuchi K, Onodera Y, Ise K, Takase K, Sugawara A, Hattangady N, Rainey WE, Satoh F, Sasano H. PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues. J Mol Endocrinol. 2014; 52: 159-167.
106. Nakamura Y, Hattangady NG, Ye P, Satoh F, Morimoto R, Ito-Saito T, Sugawara A, Ohba K, Takahashi K, Rainey WE, Sasano H. Aberrant gonadotropin-releasing hormone receptor (GnRHR) expression and its regulation of CYP11B2 expression and aldosterone production in adrenal aldosterone-producing adenoma (APA). Mol Cell Endocrinol. 2014; 384: 102-108.
107. Kudo M, Matsuda K, Sugawara K, Iki Y, Kogure N, Saito-Ito T, Shimizu K, Sato I, Takeo Yoshikawa T, Uruno A, Ito R, Yokoyama A, Saito-Hakoda A, Ito S, Sugawara A. ARB affects nicotine-induced gene expression profile in human coronary artery endothelial cells. World J Hypertens. 2014; 4: 7-14.
108. Saito-Hakoda A, Kogure N, Yoshikawa T, Shimizu K, Iki Y, Sato I, Kudo M, Uruno A, Matsuda K, Parvin R, Sugawara K, Yokoyama A, Ito S, Sugawara A. Is heparan sulfate in the glomerular basement membrane necessary for the etiology of diabetic nephropathy? J Biomol Res Ther. 2014; 3: e127.
109. Kudo M, Satoh F, Aoki S, Morimoto R, Iwakura Y, Ono Y, Matsuda K, Sugawara A, Yoshida K, Sato K, Ito S. Assisting the diagnosis of Cushing syndrome by pattern recognition methods, using a combination of eight routine tests, and their multiple correlation with serum cortisol. Biomedicine & Aging Pathology. 2014; 4: 257-264.
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112. Uruno A, Saito-Hakoda A, Yokoyama A, Kogure N, Matsuda K, Parvin R, Shimizu K, Sato I, Kudo M, Yoshikawa T, Kagechika H, Iwasaki Y, Ito S, Sugawara A. Retinoic acid receptor-α up-regulates proopiomelanocortin gene expression in AtT20 corticotroph cells. Endocr J. 2014; 61: 1105-1114.
113. Nakamura T, Yoshikawa T, Naganuma F, Mohsen A, Iida T, Miura Y, Sugawara A, Yanai K. Role of histamine H3 receptor in glucagon-secreting αTC1.6 cells. FEBS Open Bio. 2015; 5: 36-41.
114. Saito-Hakoda A, Uruno A, Yokoyama A, Shimizu K, Parvin R, Kudo M, Saito-Ito T, Sato I, Kogure N, Suzuki D, Shimada H, Yoshikawa T, Fujiwara I, Kagechika H, Iwasaki Y, Kure S, Ito S, Sugawara A. Effects of RXR agonists on cell proliferation/apoptosis and ACTH secretion/Pomc expression. PLoS One. 2015; 10: e0141960.
115. Ito R, Shimada H, Yazawa K, Sato I, Imai Y, Sugawara A, Yokoyama A. Hydroxylation of methylated DNA by TET1 in chondrocyte differentiation of C3H10T1/2 cells. Biochem Biophys Rep. 2016; 5: 134-140.