Yangseok Chae, MD, PhD
Professor of Pathology

Anam Hospital, Korea University Medical Center
Seoul, South Korea
Email: chaeys21@korea.ac.kr


  • 1987- 1981: Ph. D - Korea University Graduate School
  • 1981- 1979: Master - Korea University Graduate School
  • 1978- 1972: M.D - Korea University College of Medicine
Postgraduate Training
  • 1983 - 1979: Residency in Anatomic Pathology, Korea University Hospital
  • 1979 - 1978: Internship in Korea University Hospital



Research Interest

  • Anatomic Pathology

Scientific Activities

  • Present - 1997: Professor, Department of Pathology, Korea University
  • 2011 - 2007: Chairman, Department of Pathology, Korea University
  • 2007 - 1999: Director, Department of Pathology, Korea University Anam and Guro Hospital
  • 1997 - 1992: Associate professor, Department of Pathology, Korea University
  • 1992 - 1988: Assistant professor, Dept. of Pathology & Lab. medicine, Korea University
  • 1988 - 1986: Instructor, Dept. of Pathology & Lab. Medicine, Korea University
  • 1986 - 1983: Chief Pathologist, Aeromedical Research Center, ROKorea Air Force
  • Present - 1979: Membership, Korean Society of Pathologists
  • Present - 1986: Membership, Korean Society of Cytopathologists
  • 2010 - 2010: Vice President, Korean Society of Pathologists
  • 2009 - 2009: Vice President, Korean Thyroid Association
  • 2010 - 2006: Director of Board Examination, Korean Society of Pathologists
  • 2007 - 1999: Director, General and Academic Affairs, Korean Society of Pathologists and Korean Society of Cytopathologists
  • Member and director of Korean Institutional Review Board


  1. Hwang GY, Baek DW, Cho HJ, Lee SJ, Chae YS, Kang BW, et al. Elevated Neutrophil-to-Lymphocyte Ratio Predicts Survival in Patients with Advanced Gastric Cancer Treated with Trastuzumab Combination Chemotherapy. Anticancer Res. 2018 May;38(5):3151-3156.
  2. Kim WH, Lee SW, Kim HJ, Chae YS, Jeong SY, Jung JH, Park HY, Lee WK. Prediction of Advanced Axillary Lymph Node Metastases (ypN2-3) Using Breast MR imaging and PET/CT after Neoadjuvant Chemotherapy in Invasive Ductal Carcinoma Patients. Sci Rep. 2018 Feb 16;8(1):3181.
  3. Lee SJ, Lee J, Kim WW, Jung JH, Park HY, Park JY, Chae YS. Del-1 Expression as a Potential Biomarker in Triple-Negative Early Breast Cancer. Oncology. 2018;94(4):243-256.
  4. Kim BH, Kim MY, Chae YS. Background Registration-Based Adaptive Noise Filtering of LWIR/MWIR Imaging Sensors for UAV Applications.Sensors (Basel). 2017 Dec 27;18(1). pii: E60.
  5. Kim WH, Kim HJ, Jung JH, Park HY, Lee J, Kim WW, Park JY, Chae YS, Lee SJ. Ultrasound-Guided Restaging and Localization of Axillary Lymph Nodes After Neoadjuvant Chemotherapy for Guidance of Axillary Surgery in Breast Cancer Patients: Experience with Activated Charcoal. Ann Surg Oncol. 2018 Feb;25(2):494-500.
  6. Park YH, Im SA, Kim SB, Sohn JH, Lee KS, Chae YS, et al. Phase II, multicentre, randomised trial of eribulin plus gemcitabine versus paclitaxel plus gemcitabine as first-line chemotherapy in patients with HER2-negative metastatic breast cancer. Eur J Cancer. 2017 Nov;86:385-393.
  7. Jung J, Chae YS, Kim CH, Lee Y, Lee JH, Kim DS, Yu YD, Kim JY. Combined Adenosquamous and Large Cell Neuroendocrine Carcinoma of the Gallbladder.J Pathol Transl Med. 2018 Mar;52(2):121-125.
  8. Kim JY, Kim CH, Lee Y, Lee JH, Chae YS. Tumour infiltrating lymphocytes are predictors of lymph node metastasis in early gastric cancers. Pathology. 2017 Oct;49(6):589-595.
  9. Lee J, Park HY, Jung JH, Kim WW, Chae YS, Lee SJ, Lee S, Bae Y. Lymph node status as a prognostic factor in BRCA-positive breast cancer. J Surg Res. 2017 Jul;215:125-131.
  10. Lee J, Park HY, Kim WW, Lee SJ, Jeong JH, Kang SH, Jung JH, Chae YS. Biological function of long noncoding RNA snaR in HER2-positive breast cancer cells. Tumour Biol. 2017 Jun;39(6):1010428317707374.
  11. Park S, Kang BW, Lee SJ, Yoon S, Chae YS, Kim JG, et al. Clinical significance of systemic chemotherapy after curative resection of metachronous pulmonary metastases from colorectal cancer. Cancer Chemother Pharmacol. 2017 Jul;80(1):187-193.
  12. Lee J, Jung JH, Kim WW, Chae YS, Lee SJ, Park HY. Comparison of 5-year oncological outcomes of breast cancer based on surgery type. ANZ J Surg. 2018 May;88(5):E395-E399.
  13. Kang Y, Chae YS, Kim CH, Lee Y, Kim DS, Yu YD, Kim JY. Hyalinizing Cholecystitis and Associated Carcinoma: A Case Report. J Pathol Transl Med. 2018 Jan;52(1):64-66.
  14. Kim JY, Do YR, Song HS, Cho YY, Ryoo HM, Bae SH, Kim JG, Chae YS, et al. Multicenter Phase II Clinical Trial of Genexol-PMĀ® with Gemcitabine in Advanced Biliary Tract Cancer. Anticancer Res. 2017 Mar;37(3):1467-1473.
  15. Jung J, Kang Y, Lee YJ, Kim E, Ahn B, Lee E, Kim JY, Lee JH, Lee Y, Kim CH, Chae YS. Comparison of the Mismatch Repair System between Primary and Metastatic Colorectal Cancers Using Immunohistochemistry. J Pathol Transl Med. 2017 Mar;51(2):129-136.
  16. Lee SJ, Kang BW, Kim JG, Jung JH, Lee J, Kim WW, Park HY, Jeong JH, Jeong JY, Park JY, Park JH, Chae YS. AQP5 Variants Affect Tumoral Expression of AQP5 and Survival in Patients with Early Breast Cancer. Oncology. 2017;92(3):153-160.
  17. Lee J, Jung JH, Chae YS, Park HY, Kim WW, Lee SJ, Jeong JH, Kang SH. Long Noncoding RNA snaR Regulates Proliferation, Migration and Invasion of Triple-negative Breast Cancer Cells. Anticancer Res. 2016 Dec;36(12):6289-6295.
  18. Yoon W, Park YC, Kim J, Chae YS, Byeon JH, Min SH, et al. Application of genetically engineered Salmonella typhimurium for interferon-gamma-induced therapy against melanoma. Eur J Cancer. 2017 Jan;70:48-61.
  19. Lee IH, Lee SJ, Kang BW, Chae YS, Baek D, Hwang S, et al. Pilot study of FMC (5-fluorouracil, mitomycin C, and cisplatin) with radiotherapy for patients with anal cancer. Cancer Chemother Pharmacol. 2016 Dec;78(6):1263-1267.
  20. Park S, Kang SY, Kwon GY, Kwon JE, Kim SK, Kim JY, Kim CH, Kim HJ, Moon KC, Pyo JY, Park WY, et al. Clinicopathologic Characteristics and Mutational Status of Succinate Dehydrogenase Genes in Paraganglioma of the Urinary Bladder: A Multi-Institutional Korean Study. Arch Pathol Lab Med. 2017 May;141(5):671-677.
  21. Moon PG, Lee JE, Cho YE, Lee SJ, Chae YS, Jung JH, Kim IS, Park HY, Baek MC. Fibronectin on circulating extracellular vesicles as a liquid biopsy to detect breast cancer. Oncotarget. 2016 Jun 28;7(26):40189-40199.
  22. Lee SH, Shim J, Cheong YH, Choi SL, Jun YW, Lee SH, Chae YS, Han JH, et al. ApCPEB4, a non-prion domain containing homolog of ApCPEB, is involved in the initiation of long-term facilitation. Mol Brain. 2016 Oct 22;9(1):91.
  23. Kim SH, Jung KH, Kim TY, Im SA, Choi IS, Chae YS, Baek SK, et al. Prognostic Value of Axillary Nodal Ratio after Neoadjuvant Chemotherapy of Doxorubicin/Cyclophosphamide Followed by Docetaxel in Breast Cancer: A Multicenter Retrospective Cohort Study. Cancer Res Treat. 2016 Oct;48(4):1373-1381.
  24. Lee YJ, Kim S, Kang Y, Jung J, Lee E, Kim JY, Lee JH, Lee Y, Chae YS, Kim CH. Does Polymerase Chain Reaction of Tissue Specimens Aid in the Diagnosis of Tuberculosis? J Pathol Transl Med. 2016 Nov;50(6):451-458.
  25. Moon JH, Lee BH, Kim JA, Lee YJ, Chae YS, Yhim HY, Kwak JY, et al. Clinical impact of induction treatment modalities and optimal timing of radiotherapy for the treatment of limited-stage NK/T cell lymphoma. Leuk Res. 2016 Oct;49:80-7.
  26. Lee J, Jung JH, Kim WW, Hwang SO, Chae YS, Lee SJ, Yang JD, Lee JW, Park HY. Five-Year Oncologic Outcomes of Volume Displacement Procedures After Partial Mastectomy for Breast Cancer. Clin Breast Cancer. 2017 Feb;17(1):70-75.
  27. Lee DY, Hwang SM, An JH, Son KR, Baek SK, Kim SG, Chae YS, Jung KY. Predicting Extrathyroidal Extension in Patients With Papillary Thyroid Microcarcinoma According to a BRAF Mutation. Clin Exp Otorhinolaryngol. 2017 Jun;10(2):174-180.
  28. Kang BW, Jeon HS, Chae YS, Lee SJ, Park JS, Choi GS, Kim JG. Impact of Genetic Variation in MicroRNA-binding Site on Susceptibility to Colorectal Cancer. Anticancer Res. 2016 Jul;36(7):3353-61.
  29. Kannan V, Inamdar AI, Pawar SM, Kim HS, Park HC, Kim H, Im H, Chae YS. Facile Route to NiO Nanostructured Electrode Grown by Oblique Angle Deposition Technique for Supercapacitors. ACS Appl Mater Interfaces. 2016 Jul 13;8(27):17220-5.
  30. Kang Y, Lee YJ, Jung J, Lee Y, Won NH, Chae YS. Morphometric Analysis of Thyroid Follicular Cells with Atypia of Undetermined Significance.J Pathol Transl Med. 2016 Jul;50(4):287-93.
  31. Ko H, Son S, Jeon J, Thambi T, Kwon S, Chae YS, Kang YM, Park JH. Tumor microenvironment-specific nanoparticles activatable by stepwise transformation.J Control Release. 2016 Jul 28;234:68-78.
  32. Lee SJ, Kang BW, Chae YS, Kim HJ, Park SY, Park JS, Choi GS, Kim JG. Pilot Study of Neoadjuvant Chemoradiotherapy with Three Cycles of 5-Fluorouracil Plus Leucovorin for Treatment of Locally Advanced Rectal Cancer.Ann Surg Oncol. 2016 Mar;23(3):894-9.
  33. Han HS, Lee M, An JY, Son S, Ko H, Lee H, Chae YS, Kang YM, Park JH. pH-responsive carboxymethyl dextran-based conjugate as a carrier of docetaxel for cancer therapy.J Biomed Mater Res B Appl Biomater. 2016 May;104(4):789-96 A
  34. Lee J, Jung JH, Kim WW, Hwang SO, Kim HJ, Park JY, Chae YS, Yang JD, Park HY.The role of preoperative breast magnetic resonance (MR) imaging for surgical decision in patients with triple-negative breast cancer.J Surg Oncol. 2016 Jan;113(1):12-6.
  35. Kim JM, Sohn JH, Cho MY, Kim WH, Chang HK, Jung ES, Kook MC, Jin SY, Chae YS, et al. Pre- and post-ESD discrepancies in clinicopathologic criteria in early gastric cancer: the NECA-Korea ESD for Early Gastric Cancer Prospective Study (N-Keep).Gastric Cancer. 2016 Oct;19(4):1104-13.
  36. Moon PG, Lee JE, Cho YE, Lee SJ, Jung JH, Chae YS, Bae HI, Kim YB, Kim IS, Park HY, Baek MC. Identification of Developmental Endothelial Locus-1 on Circulating Extracellular Vesicles as a Novel Biomarker for Early Breast Cancer Detection.Clin Cancer Res. 2016 Apr 1;22(7):1757-66.
  37. Oh SY, Kim WS, Kim JS, Chae YS, Lee GW, Eom HS, et al. A phase II study of oxaliplatin and prednisone for patients with relapsed or refractory marginal zone lymphoma: Consortium for Improving Survival of Lymphoma trial.Leuk Lymphoma. 2016;57(6):1406-12.
  38. Kim DN, Chae YS, Kim MY. X-ray and optical stereo-based 3D sensor fusion system for image-guided neurosurgery. Int J Comput Assist Radiol Surg. 2016 Apr;11(4):529-41.

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