Education

Biography

Dr. Sarah Riley completed her BS in Chemistry at the University of South Carolina. She then moved to St. Louis University for graduate school, earning her doctorate in Biochemistry and Molecular Biology. She discovered a love for toxicology and pharmacology during her fellowship in Clinical Chemistry at Washington University in St. Louis. She extended her fellowship to gain additional experience in Pediatric Toxicology. She also completed 3 years of post-graduate research studying the pharmacology of buprenorphine. After finished her fellowships in 2011, Dr. Riley became the co-director of the Clinical Laboratory at St. Louis Children’s Hospital, where she co-directed the toxicology section. In 2017, she joined the faculty at St. Louis University where she is Associate Professor of Pathology and Pediatrics, Director of the St. Louis University Forensic Toxicology, and Chief Forensic Toxicologist for St. Louis City and St. Louis County.

Research Interest

• Clinical Toxicology
• Forensic Toxicology
• Clinical Mass Spectrometry
• Global Health
• Laboratory Outreach

Scientific Activities

Current Positions and Institution

Previous Professional experience

• Assistant Professor of Pediatrics, 2013-2016
• Assistant Professor of Pathology and Immunology
• Instructor of Anesthesiology
• Faculty Scholar, Institute of Public Health, Washington University School of Medicine
• Medical Director of Ancillary Services and Point of Care
• Co-Medical Director of Core Laboratory: Clinical Chemistry, Toxicology, St. Louis Children’s Hospital
• Instructor of Pediatrics, Washington University School of Medicine, 2011-2013
• Instructor of Pathology and Immunology, Washington University School of Medicine, 2011-2013

Hospital and Clinical Staff appointments

Professional Society memberships

• American Association of Clinical Chemistry
• National Academy of Clinical Biochemistry
• Academy of Clinical Laboratory Physicians and Scientists
• Midwest Association of Toxicology and Therapeutic Drug Monitoring – Lifetime Member

Honorary Societies, Honors and Awards

• The Association for Mass Spectrometry: Applications for the Clinical - 2015
• Laboratory, Laboratory Director Travel Grant (competitive application) Fellow of the National Academy of Clinical Biochemistry - 2013
• American Association of Clinical Chemistry Outstanding Speaker Award - 2012
• Early Career Women Faculty in Medicine and Science Leadership Seminar (competitive application) - 2012
• Paul E. Strandjord Young Investigator Award, With Distinction - 2011
• Academy of Clinical Laboratory Physicians and Scientists, Chief Fellow in Clinical Chemistry, Department of Pathology and Immunology - 2010-2011
• Washington University School of Medicine, Alpha Sigma Nu, Saint Louis University - 2008
• Presidential Graduate Research Assistantship, Saint Louis University – 2005

Publications

1. Brown SM, Smith DM, Alt N, Thorpe SR, Baynes JW. Tissue-specific variation in glycation of proteins in diabetes: evidence for a functional role of amadoriase enzymes. Ann N Y Acad Sci. 2005;1043:817-23. doi:10.1196/annals.1333.094 PMID:16037309
2. Brown SM, Upadhya R, Shoemaker JD, Lodge JK. Isocitrate dehydrogenase is important for nitrosative stress resistance in Cryptococcus neoformans, but oxidative stress resistance is not dependent on glucose-6-phosphate dehydrogenase. Eukaryot Cell. 2010;9(6):971-80. doi:10.1128/EC.00271-09 PMCID:PMC2901651 PMID:20400467
3. Dallas J, Brown SM, Hock K, Scott MG, Skrupky LP, Boyle WA 3rd, Kollef MH. Diagnostic utility of plasma procalcitonin for nosocomial pneumonia in the intensive care unit setting. Respir Care. 2011;56(4):412-9. doi:10.4187/respcare.00979 PMID:21255510
4. Fan J, Brown SM, Tu Z, Kharasch ED. Chemical and enzyme-assisted syntheses of norbuprenorphine-3-β-D-glucuronide. Bioconjug Chem. 2011;22(4):752-8. doi:10.1021/bc100550u PMCID:PMC3091394 PMID:21434652
5. Brown SM, Holtzman M, Kim T, Kharasch ED. Buprenorphine metabolites, buprenorphine-3-glucuronide and norbuprenorphine-3-glucuronide, are biologically active. Anesthesiology. 2011;115(6):1251-60. doi:10.1097/ALN.0b013e318238fea0 PMCID:PMC3560935 PMID:22037640
6. Brown SM, Campbell SD, Crafford A, Regina KJ, Holtzman MJ, Kharasch ED. P-glycoprotein is a major determinant of norbuprenorphine brain exposure and antinociception. J Pharmacol Exp Ther. 2012;343(1):53-61. doi:10.1124/jpet.112.193433 PMCID:PMC3464040 PMID:22739506
7. Mitsios JV, McClellan A, Brown S, Gronowski AM. Human chorionic gonadotropin and α-fetoprotein in cerebral spinal fluid: method validation and retrospective review. Clin Biochem. 2014;47(7-8):632-5. doi:10.1016/j.clinbiochem.2014.01.008 PMID:24462967
8. Li F, Guo CJ, Huang CC, Yu G, Brown SM, Xu S, Liu Q. Transient receptor potential A1 activation prolongs isoflurane induction latency and impairs respiratory function in mice. Anesthesiology. 2015;122(4):768-75. doi:10.1097/ALN.0000000000000607 PMID:25646842
9. DeMarco, ML, Dietzen, DJ, Brown, SM. Sweating the small stuff: adequacy and accuracy in sweat chloride determination. Clin Biochem. 2015;48(6):443-448. doi:10.1016/j.clnbiochem.2014.12.011 PMID:25530017

Invited Publications and Review Articles

1. Brown SM, Campbell LT, Lodge JK. Cryptococcus neoformans, a fungus under stress. Curr Opin Microbiol. 2007;10(4):320-5. PMCID: PMC2570326 PMID: 17707685
2. Andrews D, Brown SM. After the disaster: Sustaining point-of-care testing in a resource-poor environment. Point of Care. 2013;12:23-26.
3. Brown SM, Dickerson J. The struggle is real: lab leaders discuss utilization challenges during a 2-day summit J Am Lab Med. 2016;1(3):306-309.
4. Brown SM. Monthly Contributor Lab Med Global Health. 2016.
5. Patel K, Brown SM, Dietzen DJ. Listening Closely when the Volume is Turned Down: Challenges to Small Volume Testing Clin Lab News. 2016.
6. Brown SM, Haymond, S. To fight Zika and other global diseases, developing countries need better clinical laboratories: Editorial https://222.statnews.com/2016/09/29/global-disease-better-clinical-laboratories/. 2016.
7. Brown SM. Preventing the next Flint: Interviewed by Julie Kirkwood Clin Lab News. 2016;43(11):12-15.
8. Tesfazghi MT, Riley SB. Lead poisoning in a 7-year-old boy with attention deficit/hyperactivity disorder. ASCP Case Rep Surg Pathol. 2017;SP17-3.

Book Chapters

1. Brown SM. Gamma-glutamyl-transferase. In: Dazmierczak S and Azzazy H, eds. Diagnostic Enzymology Berlin/Boston: Walter de Gruyter GmbH; 2014:121-134.
2. Wilen CB, Orner CS, Brown SM. Sustaining point-of-care testing in a resource-limited environment: Experiences in Hispaniola. In: Corbin C and Kost G, eds. Global Point of Care: Strategies for Disasters, Emergencies, and Public Health Resilience Washington, DC: AACC Press; 2015:439-443.
3. Brown SM. Public Health and Prevention: Spotlight on Pediatric Laboratory Medicine In: Advancing Children's Health Through Pediatric Laboratory Medicine: The Unique Healthcare Needs of Children First ed. Washington, DC: AACC; 2016:pp. 4-5.
4. Brown, SM. Inborn Errors of Metabolism In: Clarke W, eds. Contemporary Practice in Clinical Chemistry 3rd ed. Washington, DC: AACC Press; 2016:Chapter 42 pp. 651-663 .
5. Brown, SM, Dickerson J. Pediatric Laboratory Medicine In: Clarke W, eds. Contemporary Practice in Clinical Chemistry 3rd ed. Washington, DC: AACC Press; 2016:Chapter 50, pp. 763-769.
6. Jones P, Brown SM. Day to Day Pediatric Clinical Chemistry In: Jones P, Bennett MB, eds. Pediatric Laboratory Medicine Columbus, OH: McGraw-Hill; 2016:(in press).
7. Patel K and Brown SM. Point of Care Testing in Pediatrics In: Jones P & Bennett M, eds. Pediatric Laboratory Medicine Columbus, OH: McGraw-Hill; 2016:(in press).
8. Schindler EM, Brown SM, Scott M. Blood Gases and Electrolytes In: Brutis, Ashwood, Bruns, eds. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics 6th ed. Washington, DC: AACC Press; 2017:(in press).