John Erby Wilkinson, MS, DVM, PhD
Professor of Comparative Pathology

University of Michigan Medical School
Ann Arbor, Michigan, USA
Phone: 734-657-0281


1970-1974 BSE Duke University, Durham, North Carolina
1974-1976 MS University of Tennessee, Knoxville, Tennessee
1976-1980 DVM Cornell University, Ithaca, New York
1982-1987 PhD Pathology, New York State College of Veteirnary Medicine, Cornell University, Ithaca, New York, USA
Post Doctorial Training
1982-1983 Residency, Cornell University, Ithaca, New York, USA
1984-1987 Postdoctoral Fellow, NIH Individual Postdoctoral Fellow, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
Additional Education
1985 Certificate in Pathology, Cornell University, USA


My primary research interest is in the pathology of animal models, especially models of cancer and aging. I am a D.V.M, Ph.D and Diplomate of the American College of Veterinary Pathologists. I have been continuously working on comparative/veterinary pathology for 34 years. I have been doing primarily mouse pathology for 29 of those years. During that time, as a PI and as a collaborator, I have done extensive studies in general and experimental pathology, cancer pathology, pathology of aging, transgenic animal pathology, developmental biology, general rodent pathology, immunology, and genetics.  I started working with mutant mouse models (Foxp3) in 1987 and GEMMs (PKD) in 1989. In my role as Phenotyping Core Director and veterinary pathologist for research animals at the University of Michigan (UM), I have had the opportunity to see a vast spectrum of cancer, aging, and related pathology.  Recently, I have been primarily committed to 1) studies of genetic models of cancer at the University of Michigan, Cold Spring Harbor Laboratory (CSHL), and Memorial Sloan-Kettering Cancer Center (MSKCC) and 2) pathology of aging with the NIA NTP program and the University of Washington. Three decades of doing mouse pathology are a great advantage in the correct analysis of animal models of aging and cancer.  The differences in mice and humans, strain effects, sex effects, background lesions, and spontaneous and aging lesions in the mouse can be confusing to a novice. Furthermore, mouse models sometimes have different morphologic characteristics than the same cancer in humans. However, the cancers in animal models generally share all the relevant biology, genetics, and response to manipulation, which makes them valid models. In a few cases, the morphology and complex biology cannot be completely reproduced in the mouse due to inherent differences in mice and humans and interpretation of the pathology and biology are more complex. For these reasons, the pathology must be interpreted in the context of the peculiarities of mice and the similarities and differences between humans and mice. Otherwise, the interpretation can be misguided. This requires an experienced comparative pathologist. With regards to this proposal, I am uniquely qualified by my previous experience and particularly my experience with this methodology to test for toxicity, tumor growth, and tumor response to therapy.  In the previous and ongoing studies, interesting, significant, and unexpected lesions have been identified. I am very excited about the proposed studies and look forward to a productive collaboration.

Research Interest

  • Pathobiology of aging
  • Comparative pathology of cancer
  • Molecular basis of disease
  • Molecular biology and genetics of cancer
  • Pathology of animal models of cancer and aging
  • Pathology of genetically engineered mice

Scientific Activities

1987 - 1993 Assistant Professor, College of Veterinary Medicine, University of Tennessee
1992 - 1993  Assistant Professor, Mammalian Genetics Section, Oak Ridge National Laboratory
1993 - 2001 Associate Professor, College of Veterinary Medicine, University of Tennessee
1993 - 2001 Associate Professor, Mammalian Genetics Section, Oak Ridge National Laboratory
1994 - 1997  Director of Research, College of Veterinary Medicine, University of Tennessee
2001- Associate Professor of Comparative Pathology, University of Michigan, Ann Arbor, Michigan
2001- Associate Professor of Pathology, University of Michigan, Ann Arbor, Michigan
2001 - 2011 Director of the Mouse Phenotyping Core, University of Michigan
2001-2011 Director of the Animal Diagnostic Laboratory. University of Michigan
2001- 2008 Pathologist: Comprehensive Cancer Center, University of Michigan
2001-2006 NIH Mid career Awards in Mouse Pathobiology
2006- Adjunct Associate Professor, Department of Veterinary Pathology, Michigan State University 
2007- Founding Member Mouse Pathologist Consortium
2008- Pathologist: Nathan Shock Geriatric Center, University of Michigan
2009- Faculty: Center for Genomic Pathology
2013- Consulting Pathologist, Cold Spring Harbor Laboratory
2015- Professor of Comparative Pathology, University of Michigan, Ann Arbor, Michigan
2015- Professor of Pathology, University of Michigan, Ann Arbor, Michigan
Memberships in Professional Societies
  • Member, American Veterinary Medical Association
  • Elected member, Society for Investigative Dermatology
  • Member, American College of Veterinary Pathology (exam)
  • Member, Tissue Culture Association
  • Elected member, American Association of Pathologists
  • Member, New York Academy of Science
  • Member, American Association for the Advancement of Science
  • Member, American Association of Laboratory Animal Science
  • Member, American Society of Investigative Pathology
  • Member, C L Davis Foundation
Certifications and Licensure
1980 DVM, New York
1980 DVM, Virginia      
1985 American College of Veterinary Pathologists (ACVP)
Honors and Awards
  • Cum laude, Duke University
  • Gamma Sigma Delta
  • AVMA Auxiliary Scholarship Award
  • Honors, NYSCVM
  • Phi Kappa Phi
  • Technical Merit Award for Outstanding Publication at Oak Riidge National Laboratory
  • Smith Kline Beecham Award for Excellence in Research
  • Top Ten Breakthroughs in 2009 Science (Science)
  • Collaborator awarded Crafoord Prize (Swedish Academy) based on collaborations


  1. Wilkinson JE, Bell MC, Bacon JA, Masincupp FB: Effects of supplemental selenium on swine. I. Gestation and lactation. J AnimSci 44(2): 224-8, 1977.
  2. Wilkinson JE, Bell MC, Bacon JA, Melton CC: Effects of supplemental selenium on swine. II. Growing- finishing. J AnimSci 44(2): 229-33, 1977. 
  3. Guard C, Wilkinson JE: Hemangiosarcoma in a cow. J Am Vet Med Assoc 185(7): 789-790, 1984. 
  4. Center SA, Wilkinson JE, Smith CA, Erb H, Lewis RM: 24-hour urine protein/creatinine ratio in dogs with protein losing nephropathies.  J Am Vet Med Assoc 187(8): 820-824, 10/1985.
  5. Wilkinson JE, Smith CA, Castleman WL, Lewis RM: Fibrillary deposits in glomerulonephritis in a horse. Vet Pathol. 22(6): 647-649, 1985. 
  6. Picut CA, Wilkinson JE, Suter M, Lee CS, Lewis RM: Pemphigus research: new directions. An editorial review. Immunol Invest 15(7): 689-732, 1986. 
  7. Center SA, Smith CA, Wilkinson E, Erb HN, Lewis RM: Clinicopathologic, renal immunofluorescent and light microscopic features of glomerulonephritis in the dog: 41 cases (1975-1985) J Am Vet Med Assoc 190(1): 81-90, 1987. 
  8. Lee CS, Picut CA, Wilkinson JE, Lewis RM: Immunoelectron microscopic observation on the stratified squamous epithelial cells of pemphigus vulgaris. Korean J Elec Microscop 172(2): 1- 22, 1987.
  9. Wilkinson JE, Smith C, Suter M, Lewis RM: Long-term cultivation of canine keratinocytes. J Invest Dermatol. 88(2): 202-206, 1987. 
  10. Suter MM, Wilkinson JE, Greenberger L, Smith CA, Lewis RM: Monoclonal antibodies: cell surface markers for canine keratinocytes. Am J Vet Res 48(9): 1367-1371, 1987. 
  11. Dunstan RW, Sills RC, Wilkinson JE, Paller AS, Hashimoto KH: A disease resembling junctional epidermolysis bullosa in a toy poodle. Am J Dermatopathol 10(5): 442-447, 1988. 
  12. Wilkinson JE, Smith CA, Suter MM, Falchek W, Lewis RM: Role of plasminogen activator in pemphigus vulgaris. Am J Pathol. 134(3): 561-569, 1989.  
  13. Wilkinson JE, Lee CS, Lillie JH, Suter MM, Lewis RM: Ultrastructure of cultured canine oral  keratinocytes. Am J Vet Res. 50(7): 1161-1165, 1989. 
  14. Panjehpour M, Overholt B F, Milligan A J, Swaggerty M W, Wilkinson J E, Klebanow E R: Nd:YAG laser- induced interstitial hyperthermia using a long frosted contact probe. Lasers Surg Med 10(1): 16-24, 1990. 
  15. Suter MM, Greenberger LJ, Wilkinson JE, Lewis RM: Differential expression of cell surface antigens of canine keratinocytes defined by monoclonal antibodies. J HistochemCytochem. 38(4): 541-549, 1990. 
  16. Suter MM, Wilkinson JE, Dougherty EP, Lewis RM: Ultrastructural localization of pemphigus vulgaris antigen on canine keratinocytes in vivo and in vitro. Am J Vet Res. 51(4): 507-511, 1990. 
  17. Munson L, Wilkinson JE, Schlafer DH: Effects of substrata on the polarization of bovine endometrial epithelial cells in vitro. Cell Tissue Res. 261(1): 155-161, 1990. 
  18. Wilkinson JE, Smith CA, Suter MM, Lewis RM: Antigen expression in cultured oral keratinocytes from dogs. Am J Vet Res. 52(3): 445-448, 1991. 
  19. Silva-Krott IU, Wilkinson JE: Hypoplastic left ventricle and aortic atresia in a calf. Vet Pathol. 28(3): 253-254, 1991. 
  20. Godfrey VL, Wilkinson JE, Russell LB: X-linked lymphoreticular disease in the scurfy (sf) mutant mouse. Am J Pathol. 138(6): 1379-1387, 1991. 
  21. Godfrey VL, Wilkinson JE, Rinchik EM, Russell LB: Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in a sf thymic environment: potential model for thymic education. Proc Natl AcadSci U.S.A. 88(13): 5528-5532, 1991. 
  22. Shamay A, Pursel VG, Wilkinson E, Wall RJ, Hennighausen L: Expression of the whey acidic protein in transgenic pigs impairs mammary development Transgenic Res. 1(3): 124-132, 1992. 
  23. Cook SM, Dean DF, Golden DL, Wilkinson JE, Means TL: Renal failure attributable to atrophic glomerulopathy in four related rottweilers. J Am Vet Med Assoc 202(1): 107-109, 1993. 
  24. Dressler GR, Wilkinson JE, Rothenpieler UW, Patterson LT, Williams-Simons L, Westphal H: Deregulation of Pax-2 expression in transgenic mice generates severe kidney abnormalities. Nature. 362 (6415): 65-67, 1993. 
  25. Edwards DF, Parker JW, Wilkinson JE, Helman RG: Plasma cell myeloma in the horse. A case report and literature review. J Vet Intern Med. 7(3): 169-176, 1993. 
  26. Ford VA, Wilkinson JE, Kennel SJ: Thrombomodulin distribution during murine development. Roux Arch Dev Biol 202(6): 364-370, 1993.
  27. Moyer JH, Lee-Tischler MJ, Kwon HY, Schrick JJ, Avner ED, Sweeney WE, Godfrey VL, Cacheiro NL, Wilkinson JE, Woychik RP: Candidate gene associated with a mutation causing recessive polycystic kidney disease in mice. Science 264(5163): 1329-1333, 1994. 
  28. Godfrey VL, Rouse BT, Wilkinson JE: Transplantation of T cell-mediated, lymphoreticular disease from the scurfy (sf) mouse. Am J Pathol. 145(2): 281-286, 1994. 
  29. Blair PJ, Carpenter DA, Godfrey VL, Russell LB, Wilkinson JE, Rinchik EM: The mouse scurfy (sf) mutation is tightly linked to Gata1 and Tfe3 on the proximal X chromosome. Mamm Genome 5(10): 652-654, 1994. 
  30. Blair PJ, Bultman SJ, Haas JC, Rouse BT, Wilkinson JE, Godfrey VL: CD4+CD8- T cells are the effector cells in disease pathogenesis in the scurfy (sf) mouse. J Immunol 153(8): 3764-3774, 1994. 
  31. Woychik RP, Wilkinson JE, Moyer JH, Lee-Tischler M, Kwon HL, Schrick JJ, Yoder B, Avner ED, Sweeney, WE, Godfrey VL: Forefronts in nephrology IV: The etiology o heredity polycystic kidney disorders: progress in cloning disease genes; insertional mutagenesis and PKD. Kidney Int 47(3): 732, 1995.
  32. Schrick JJ, Onuchic LF, Reeders ST, Korenberg J, Chen XN, Moyer JH, Wilkinson JE, Woychik RP: Characterization of the human homologue of the mouse Tg737 candidate polycystic kidney disease gene. Hum Mol Genet 4(4): 559-567, 1995.
  33. Klebig ML, Wilkinson JE, Geisler JG, Woychik RP: Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur. Proc Natl AcadSci U.S.A. 92(11):4728-4732, 1995. 
  34. Doré JJ, Wilkinson JE, Godkin JD: Early gestational expression of transforming growth factor beta isoforms by the ovine placenta. BiolReprod. 53(1): 143-152, 1995. 
  35. Derry JM, Wiedemann P, Blair P, Wang Y, Kerns JA, Lemahieu V, Godfrey VL, Wilkinson JE, Francke U: The mouse homolog of the Wiskott-Aldrich syndrome protein (WASP) gene is highly conserved and maps near the scurfy (sf) mutation on the X chromosome. Genomics 29(2): 471-477, 1995. 
  36. Yoder BK, Richards WG, Sweeney WE, Wilkinson JE, Avener ED, Woychik RP: Insertional mutagenesis and molecular analysis of a new gene associated with polycystic kidney disease. Proc Assoc Am Physicians. 107(3): 314-323, 1995. 
  37. Kanangat S, Blair P, Reddy R, Daheshia M, Godfrey V, Rouse BT, Wilkinson E, Deheshia M: Disease in the scurfy (sf) mouse is associated with overexpression of cytokine genes Eur. J. Immunol. 26(1): 161-165, 1996. 
  38. Doré JJ, Wilkinson JE, Godkin JD: Ovine endometrial expression of transforming growth factor beta isoforms during the peri-implantation period. BiolReprod. 54(5): 1080-1087, 1996. 
  39. Munson L, Wilhite A, Boltz VF, Wilkinson JE: Transforming growth factor beta in bovine placentas.  BiolReprod. 55(4): 748-755, 1996. 
  40. Yoder BK, Richards WG, Sommardahl C, Sweeney WE, Michaud EJ, Wilkinson JE, Avner ED,Woychik RP:Functionalcorrectionofrenal defectsin a mouse model forARPKDthroughexpression ofthecloned wild-type Tg737 cDNA. Kidney Int.50(4): 1240-1248, 1996. 
  41. Richards WG,Yoder BK,IsfortRJ, Detilleux PG,Foster C,Neilsen N,Woychik RP,Wilkinson JE:Oval cell proliferation associated with the murine insertional mutation TgN737Rpw. AmJPathol  149(6): 1919-1930,1996.
  42. Ziegler,SF,Ramsdell,F,Singhal,MC,Generoso,W,Wilkinson,JE,Appleby,MW:Alarge scale screen utilizing chromosomal rearrangement mutants for novel genes involved in immunoregulation. J Allergy ClinImmunol 99(1): 135-141, 1997.
  43. MynattRL, MiltenbergerRJ, KlebigML, ZemelMB, WilkinsonJE, WilkinsonWO, WoychikRP: Combined effects of insulin treatment and adipose tissue-specific agouti expression on the development of obesity. ProcNatl. AcadSci U.S.A. 94(3): 919-922,1997.
  44. WuM, Rinchik EM, WilkinsonE, Johnson DK: Inherited somatic mosaicism caused by an intracisternal A particle insertion in the mouse tyrosinase gene. Proc Natl Acad Sci. U.S.A. 94(3): 890-894, 1997.   Richards WG, Yoder BK, Isfort RJ, Detilleux PG, Foster C, Neilsen N, Woychik RP, Wilkinson JE: Isolation and characterization of liver epithelial cell lines from wild-type and mutant TgN737Rpw mice. Am J Pathol150 (4):1189-1197, 1997.
  45. Yoder BK, Richards WG, Sommardahl C, Sweeney WE, Michaud EJ, Wilkinson JE, Avner ED, Woychik RP: Differential rescue of the renal and hepatic disease in an autosomal recessive polycystic kidney disease mouse mutant. Anew model to study the liver lesion. Am J Pathol 150(6): 2231-2241,1997. 
  46. Richards WG, Yoder BK, Isfort RJ, Detilleux PG, Foster C, Neilsen N, Woychik RP, Wilkinson JE: Isolation and characterization of liver epithelial cell lines from wild-type and mutant TgN737Rpw mice. Am. J. Pathol. 150(4): 1189-1197, 04/1997.
  47. Miltenberger RJ, Mynatt RL, Wilkinson JE, Woychik RP: The role of the agouti gene in the yellow obese syndrome. JNutr. 127(9):1902S-1907S,1997.
  48. Isfort RJ, Cody DB, Doersen CJ, Richards WG, Yoder BK, Wilkinson JE, Kier LD, Jirtle RL, Isenberg JS, Klounig JE, Woychik RP: The tetratricopeptide repeat containing Tg737 gene is a liver neoplasia tumor suppressor gene.Oncogene15(15):1797-1803,1997.
  49. Michaud EJ, Mynatt RL, Miltenberger RJ, Klebig ML, Wilkinson JE, Zemel MB, Wilkison WO, Woychik RP: Role of the agouti gene in obesity. J Endocrinol.155(2):207-209,1997.
  50. Isfort RJ, Cody DB, Stuard SB, Randall CJ, Miller C, Ridder GM, Doersen CJ, Richards WG, Yoder BK, Wilkinson JE, Woychik RP: The combination of epidermal growth factor and transforming growth factor- betainduces novel phenotypicchanges in mouse liver stem cell lines. JCellSci. 110(24):3117-3129,1997. 
  51. Sommardahl CS, Woychik RP, Sweeney WE, Avner ED, Wilkinson JE: Efficacy oftaxolin theorpk mouse model of polycystic kidney disease. PediatrNephrol.11(6):728-733,1997.
  52. Munson L, Koehler JW, Wilkinson JE, Miller RE: Vesicular and ulcerative dermatopathy resembling superficial necrolytic dermatitis in captive black rhinoceroses (Dicerosbicornis).VetPathol.35(1):31-42, 1998. 
  53. Richards WG, Sweeney WE, Yoder BK, Wilkinson JE, Woychik RP, Avner ED: Epidermal growth factor receptor activity mediates renal cyst formation in polycystic kidney disease. J Clin Invest. 101(5): 935-939, 1998. 
  54. Isfort RJ, Cody DB, Richards WG, Yoder BK, Wilkinson JE, Woychik RP: Characterization of growth factor responsiveness and alterations in growth factor homeostasis involved in the tumorigenic conversion of mouse oval cells. Growth Factors 15(2): 81-94, 1998. 
  55. Hansen LA, Malarkey DE, Wilkinson JE, Rosenberg M, Woychik RE, Tennant RW: Effect of the viable- yellow (A(vy)) agoutiallele on skin tumorigenesis and humoral hypercalcemia in v-Ha-ras transgenic TGxAC mice. Carcinogenesis 19(10):1837-1845,1998.
  56. Clark LB, Appleby MW, Brunkow ME, Wilkinson JE, Ziegler SF, Ramsdell F: Cellular and molecular characterization of the scurfy mouse mutant. J Immunol 162(5): 2546-2554, 1999. 
  57. Colitz CM, Malarkey DE, Woychik RP, Wilkinson JE: Persistent hyperplastic tunica vasculosalent is and persistent hyperplastic primary vitreousin transgenicline TgN3261 Rpw. Vet Pathol37(5):422-427,2000.
  58. Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko SA, Wilkinson JE, Galas D, Ziegler SF, Ramsdell F: Disruption of a new fork head/winged-helixprotein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet27(1):68-73,2001.
  59. Zahorsky-Reeves J L, Wilkinson J E:The murine mutation scurfy (sf) results in an antigen-dependent lymphoproliferative disease with altered Tcell sensitivity. Eur J Immunol. 31(1): 196-204, 2001. 
  60. Sommardahl C, Cottrell M, Wilkinson JE, Woychik RP, Johnson DK: Phenotypic variations of orpk mutation and chromosomal localization of modifiers influencing kidney phenotype. Physiol. Genomics7 (2):127-134,2001.
  61. Zahorsky-Reeves JL, Wilkinson JE: Atransgenic mouse strain with antigen-specific T cells RAG1KO/sf/OVA) demonstrates that the scurfy(sf) mutation causes a defect in T-celltolerization. Comp (Med.52(1):58-62, 2002. 
  62. Eitzman DT, Westrick RJ, Bi X, Manning SL, Wilkinson JE, Broze GJ, Ginsburg D: Lethal perinatal thrombosis in mice resulting from the interaction of tissue factor pathway inhibitor deficiency and factor V Leiden. Circulation 105(18): 2139-2142, 2002. 
  63. Groër MW, Hill J, Wilkinson JE, Stuart A: Effects of separation and separation with supplemental stroking in BALb/c infant mice. Biol Res Nurs 3(3): 119-131, 2002. 
  64. Moore ML, Mc Kissic EL, Brown CC, Wilkinson JE, Spindler KR: Fataldisseminatedmouse adenovirus type1 infection in mice lacking B-cells or Bruton's tyrosine kinase. J Virol. 78(11): 5584-5590, 2004. 
  65. Cha KB, Karolyi IJ, Hunt A, Wenglikowski AM, Wilkinson JE, Dolan DF, Dootz G, Finnegan AA, Seasholtz AF, Hankenson KD, Siracusa LD, Camper SA: Skeletal dysplasia and male infertility locus on mouse chromosome 9.Genomics 83(6):951-960,2004.
  66. Weinberg JB, Stempfle GS, Wilkinson JE, Younger JG, Spindler KR: Acute respiratory infection with mouse adenovirus type1.Virology340(2):245-254,2005.
  67. Ray D, Wilkinson JE, Murphy HS, Lu Q, Kluve-Beckerman B, Liepnieks JJ, Benson M, Yung R, Richardson B: Aging in heterozygous Dnmt 1-deficient mice: effects on survival and DNA methylation genes, and the development of amyloidosis J Geron Biol Med Sci 61(2): 115-124, 2006.
  68. Makidon PE, Bielinska AU, Nigavekar SS, Janczak KW, Knowlton J, Scott AJ, Mank N, Cao Z, Rathinavelu S, Beer MR, Wilkinson JE, Blanco LP, Landers JJ, Baker JR: Pre-clinical evaluation of a novel nanoemulsion-based hepatitis B mucosal vaccine.PLoSONE3(8):e2954,2008.
  69. Duran-Struuck R, Hartigan A, Clouthier SG, Dyson MC, Lowler K, Gatza E, Tawara I, Toubai T, Weisiger E, Hugunin K, Reddy P, Wilkinson JE: Differential susceptibility ofC57BL/6NCr and B6.Cg-Ptprca mice to commensal bacteria after whole body irradiation in translational bone marrow transplant studies. J Transl Med 6:10, 2008.
  70. Lake AM, Xu Z, Wilkinson JE, Cain CA, Roberts WW: Renal ablation by histotripsy--does it spare the collecting system? J Urol. 179(3): 1150-1154, 2008. 
  71. Zhang J, Wilkinson JE, Gonit M, Keck R, Selman S, Ratnam M: Expression and sub-cellular localization of the CCAAT/enhancer binding protein alpha in relation to postnatal development and malignancy of the prostate. Prostate 68(11):1206-1214, 2008.
  72. Serkova NJ, Van Rheen Z, Tobias M, Pitzer JE, Wilkinson JE, Stringer KA: Utility of magnetic resonance imaging and nuclear magnetic resonance-based metabolomics for quantification of inflammatory lung injury. Am J Physiol Lung Cell Mol Physiol. 295(1): L152-L161, 2008. 
  73. Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS, Pahor M, Javors MA, Fernandez E, Miller RA: Rapamycin fed late in life extends life span in genetically heterogeneous mice. Nature 460(7253): 392-395, 2009.   (Top Discovers of 2009)
  74. Diallo-Krou E, Yu J, Colby LA, Inoki K, Wilkinson JE, Thomas DG, Giordano TJ, Koenig RJ: Paired box gene 8-peroxisome proliferator-activated receptor-gamma fusion protein and loss of phosphatase and tensin homolog synergistically cause thyroid hyperplasia in transgenicmice. Endocrinology 150(11):5181-5190, 2009.
  75. Harper JM, Wilkinson JE, Miller RA: Macrophage migration inhibitory factor-knockout mice are long lived and respond to caloric restriction. FASEBJ. 24(7): 2436-2442, /2010. 
  76. Winterroth F, Xu Z, Wang TY, Wilkinson JE, Fowlkes JB, Roberts WW, Cain CA: Examining and analyzing subcellular morphology of renal tissue treated by histotripsy. Ultrasound Med Biol 37(1):78-86, 2011.
  77. Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, de Cabo R, Fernande zE, Flurkey K, Javors MA, Nelson JF, Orihuela CJ, Pletcher S, Sharp ZD, Sinclair D, Starnes JW, Wilkinson JE, Nadon NL, Strong R: Rapamycin, but no tresveratrolor simvastatin, extends lifespan of genetically heterogeneous mice. J. GerontolABiolSciMedSci.66 A (2):191-201, 2011.
  78. Bauler TJ, Kamiya N, Lapinski PE, Langewisch E, Mishina Y, Wilkinson JE, Feng GS, King PD: Development of severe skeletal defects in induced SHP-2-deficientadultmice:a model of skeletal malformation in humans with SHP-2 mutations. Dis Model Mech 4(2): 228-239, 2011.   (Cover)
  79. Kim Y, Gelehrter SK, Fifer CG, Lu JC, Owens GE, Berman DR, Williams J, Wilkinson JE, Ives KA, Xu Z: Non-invasive pulsed cavitational ultrasound for fetal tissue ablation: feasibility study in a fetal sheep model. Ultrasound Obstet Gynecol 37(4): 450-457, 2011. 
  80. KochLG, KemiOJ, Qi N, Leng SX, Bijma P, Gilligan LJ, Wilkinson JE, Wisløff H, Høydal MA, Rolim N, Abadir PM, van Grevenhof EM, Smith GL, Burant CF, Ellingsen O, Britton SL, Wisløff U:Intrinsic aerobic capacity sets a divide foraging and longevity.CircRes.109(10):1162-1172, 2011.
  81. Dobson ME, Diallo-Krou E, Grachtchouk V, Yu J, Colby LA, Wilkinson JE, Giordano TJ, Koenig RJ: Pioglitazone induces a proadipogenic antitumor response in mice with PAX8-PPAR {gamma} fusion protein thyroid carcinoma. Endocrinology152(11):4455-4465, 2011.
  82. Lapinski PE, Kwon S, Lubeck BA, Wilkinson JE, Srinivasan RS, Sevick-Muraca E, King PD: RASA1 maintains the lymphatic vasculature in a quiescent functional state in mice. J Clin Invest. 122(2):733-747, 2012.
  83. Oh SS, Sullivan KA, Wilkinson JE, Backus C, Hayes JM, Sakowski SA, Feldman EL: Neurodegeneration and early lethality in superoxide dismutase2-deficientmice:a comprehensive analysis of the central and peripheral nervous systems. Neuroscience 212: 201-213, 2012. 
  84. Wilkinson JE, Burmeister L, Brooks SV, Chan CC, Friedline S, Harrison DE, Hejtmancik JF, Nadon N, Strong R, Wood LK, Woodward MA, Miller RA: Rapamycin slows aging in mice. Aging Cell 11(4): 675-682, 2012. 
  85. Cao SS, Zimmermann EM, Chuang BM, Song B, Nwokoye A, Wilkinson JE, Eaton KA, Kaufman RJ: The unfolded protein response and chemical chaperones reduce protein misfolding and colitis in mice. Gastroenterol 144(5):989-1000.e6, 2013.
  86. Taube S, Kolawole AO, Höhne M, Wilkinson JE, Handley SA, Perry JW, Thackray LB, Akkina R, Wobus CE: A mouse model for human norovirus. mBio 4(4): 989-1000, 2013.
  87. Allam CL, Wilkinson JE, Cheng X, Ives KA, Hall TL, Roberts WW: Histotripsy effects on the bladder trigone: functional and histologic consequences in the canine model. J Endoneurology: 27(10):1267-1271, 2013.
  88. Roca H, Hernandez J, Weidner S, Mc Eachin RC, Fuller D, Sud S, Schumann T, Wilkinson JE, Zaslavsky A, Li H, Maher CA, Daignault-Newton S, Healy PN, Pienta KJ: Transcription factors OVOL1 and OVOL2 induce the mesenchymal to epithelial transition in human cancer PLosOne8(10):e76773, 2013. 
  89. Sahashi K, Ling KK, Hua Y, Wilkinson JE, Nomakuchi T, Rigo F, Hung G, Xu D, Jiang YP, Lin RZ, Ko CP, Bennett CF, Krainer AR: Pathological impact of SMN2 mis-splicing in adult SMA mice. EMBOMol Med 5 (10): 1586-1601, 2013. 
  90. Jensen MA, Wilkinson JE, Krainer AR: Splicing factor SRSF6 regulates alternative splicing often ascin C and promotes skin hyperplasia Nat Struc Mol Biol 21:189-197,2014.
  91. Bolden JE, Tasdemir N, Dow LE, van Es JH, Wilkinson JE, Zhao Z, Clevers H, Lowe SW: Inducible in vivo silencing of Brd4 identifies potential toxicities of sustained BET protein inhibition. Cell Reports 8(6):1919-29, 2014. 
  92. Cho H, Herzka T, Zheng W, Qi J, Wilkinson JE, Bradner JE, Robinson BD, Castillo-Martin M, Cordon- Cardo C, Trotman LC: Rapid CaP, a novel GEM model for metastatic prostate cancer analysis and therapy, reveals myc as a driver of Pten-mutant metastasis. Cancer Dis 4(3): 318-33, 2014. 
  93. Okada N, Lin CP, Ribeiro MC, Biton A, Lai G, He X, Bu P, Vogel H, Jablons DM, Keller AC, Wilkinson JE, He B, Speed TP, He L: A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression Genes Dev.28(5):438-450, 2014.
  94. Harrison DE, Strong R, Allison DB, Ames BN, Astle CM, Atamna H, Fernandez E, FlurkeyK, Javors MA, Nadon NL, Nelson JF, Pletcher S, Simpkins JW, Smith D, Wilkinson JE, Miller RA:Acarbose,17-α- estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males. Aging Cell 13(2):273-82, 2014.
  95. Mazurek A, Park Y, Miething C, Wilkinson JE, Gillis J, Lowe SW, Vakoc CR, Stillman B:Acquired dependence of acute myeloid leukemia on the DEAD-Box RNA Helicase  DDX5. Cell Reports 7(6): 1887-99, 2014.
  96. Zaslona Z, Przybranowski S, Wilke C, van Rooijen N, Teitz-Tennenbaum S, Osterholzer JJ, Wilkinson JE, Moore BB, Peters-Golden M: Resident alveolar macrophages suppress, whereas recruited monocytes promote, allergic lung inflammation in murine models of asthma J Immunol 193(8): 4245-4253,2014.
  97. Palmbos PL, Wang L, Yang H, Wang Y, Leflein J, Ahmet ML, Wilkinson JE, Kumar-Sinha C, Ney GM, Tomlins SA, Daignault S, Kunju LP, Wu XR, Lotan Y, Liebert M, Ljungman ME, Simeone DM: ATDC/TRIM29 drives invasive bladder cancer formation through miRNA-mediated and epigenetic mechanisms. Cancer Res 75(23): 5155-66, 2015. 
  98. Markham BE, Kernodle S, Nemzek J, Wilkinson JE, Sigler R: Chronic Dosing with Membrane Sealant Poloxamer188 NF improves respiratory dysfunction in dystrophic Mdx and Mdx/Utrophin-/-mice. PLoS One 10(8): e0134832, 2015. 
  99. Nowak DG, Cho H, Herzka T, Watrud K, DeMarco DV, Wang VM, Senturk S, Fellmann C, Ding D, Beinortas T, Kleinman D, Chen M, Sordella R, Wilkinson JE, Castillo-Martin M, Cordon-Cardo C, Robinson BD, Trotman LC: MYC Drives Pten/Trp53-deficient proliferation and metastasis due toIL6 secretion and AKT suppression via PHLPP2.Cancer Discov 5(6):636-51, 2015.
  100. McCarthy MK, Procario MC, Twisselmann N, Wilkinson JE, Archambeau AJ, Michele DE, Day SM, Weinberg JB: Proinflammatory effects of interferon gamma in mouse adenovirus 1 myocarditis. J Virol 89 (1):468-79,2015.
  101. Yu JR, Tai Y, Jin Y, Hammell MC, Wilkinson JE, Roe JS, Vakoc CR, Van A elst L: TGF-β/Smad signaling through DOCK4 facilitates lung adenocarcinoma metastasis. Genes Dev 29(3):250-61, 2015. 
  102. Wang L, Yang H, Abel EV, Ney GM, Palmbos PL, Bednar F, Zhang Y, Leflein J, Waghray M, Owens S, Wilkinson JE, Prasad J, Ljungman M, Rhim AD, Pasca di Magliano M, Simeone DM: ATDC induces an invasive switch in KRAS-induced pancreatic tumorigenesis. Genes Dev 29(2): 171-83, 2015. 
  103. Wagenblast E, Soto M, Gutiérrez-Ángel S, Hartl CA, Gable AL, Maceli AR, Erard N, Williams AM, Kim SY, Dick opf S, Harrell JC, Smith AD, Perou CM, Wilkinson JE, Hannon GJ, Knott SR: A model of breast cancer heterogeneity reveals vascular mimicry as a driver ofmetastasis. Nature 520(7547): 358-62, 2015.
  104. Demos DS, Iyengar A, Bryner BS, Gray BW, Hoffman HR, Cornell MS, Wilkinson JE, Mazur DE, Bartlett RH, Punch JD, Rojas-Peña A: Successful porcine renal transplantation after 60 Minutes of donor warm ischemia: extracorporeal perfusion and thrombolytics. ASAIOJ. 61(4): 474-479, 2015. 
  105. Dolgachev VA, Ciotti SM, Eisma R, Gracon S, Wilkinson JE, Baker JR Jr, Hemmila MR: Nanoemulsion therapy for burn wounds is effective as a topical antimicrobial against Gram-Negative and Gram- Positive bacteria. J Burn Care Res 37(2):e104-14, 2016.
  106. Arun G, Diermeier S, Akerman M, Chang KC, Wilkinson JE, Hearn S, Kim Y, MacLeod AR, Krainer AR, Norton L, Brogi E, Egeblad M, Spector DL: Differentiation of mammary tumors and reduction in metastasis upon Malat1lncRNAloss.GenesDev 30(1):34-51,2016.
  107. Bajwa P, Nagendra PB, Nielsen S, Sahoo SS, Bielanowicz A, Lombard JM, Wilkinson JE, Miller RA, Tanwar PS: Agerelated increase in mTOR activity contributes to the pathological changes in ovarian surface epithelium 7(15): Oncotarget:7(15): 19214-19227. 2016.
  108. Chen M, Nowak DG, Narula N, Robinson, Watrud K, Ambrico A, Herzka TM1, Zeeman ME, Minderer M, Zheng W, Ebbesen SH, Plafker KS, Stahlhut C, Wang VM, Wills L, Nasar A, Castillo-Martin Cordon- Cardo C, Wilkinson JE8, Powers S, Sordella R, Altorki NK, Mittal V, Stiles BM, Plafker  SM, Trotman LC.: The nuclear transport receptor Importin-11is a tumor suppressor that maintains PTEN protein. J Cell Biol 216(3): 641-656, 2017. 
  109. Chio IOC, Jafarnejad SM, Ponz-Sarvise M, Park Y, Rivera K Palm W, Wilson J, Sangar VS, Hao Y, Öhlund D, Wright K, Filippini D, Lee EJ, Da Silva B, Schoepfer C, Wilkinson JE, Buscaglia SM, DeNicola GM, Tiriac H, Hammell M, Crawford HC, Schmidt EE, Thompson CB, Pappin DJ, Sonenberg N, Tuveson DA:NRF2promotes tumor maintenance by modulating mRNA translation in pancreatic cancer. Cell 166 (4): 963-976, 2016.
  110. Cao Z, Spilker T, Fan Y, Kalikin LM, Ciotti S, LiPuma JJ, Makidon PE1,Wilkinson JE, Baker JR Jr1,5, Wang SH: Nano emulsion is an effective antimicrobial for methicillin-resistant Staphylococcusaureus in infected wounds. Nanomedicine 12(10): 1177-1185, 2017.
  111. Zhang S, Fan G, Hao Y, Hammell M, Wilkinson JE, Tonks NK. Suppression of protein tyrosine phosphatase N23 predisposes to breast tumorigenesis via activation of FYN. Genes Dev.1(19):1939-1947, 2017.
  112. Kastenhuber ER, Lalazar G, Houlihan SL, Tschaharganeh DF, Baslan T, Chen CC, Requena D, Tian S, Bosbach B, Wilkinson JE, Simon SM, Lowe SW. DNAJB1-PRKACA fusion kinase interacts with β-catenin and the liver regenerative response to drive fibrolamellar hepatocellular carcinoma.Proc Natl AcadSci U S A.;114(50):13076-13084, 2017
  113. Dow L, Han T, Schatoff E, Murphy C, Zafra MP, Wilkinson JE, Elemento O: R-Spondin chromosome rearrangements drive Wnt-dependent tumor initiation and maintenance in the intestine. Nature Comm8:15945. doi: 10.1038/ncomms15945.
  114. Boynton FDD, Ericsson AC, Uchihashi M, Dunbar ML, Wilkinson JE.  Doxycycline induces dysbiosis in female C57BL/6NCrl mice.BMC Res Notes.;10(1):644 2017.
  115. Manchado E, Huang CH, Tasdemir N, Tschaharganeh DF, Wilkinson JE, Lowe SW. A Pipeline for DruTarget Identification and Validation. Cold Spring HarbSymp Quant Biol.;81:257-267, 2017.
  116. Roca H, Jones JD, Purica MC, Weidner S, Koh AJ, Kuo R, Wilkinson JE, Wang Y, Daignault Newton S, Pienta KJ, Morgan TM, Keller ET, Nör JE, Shea LD, McCauley LK.Apoptosis-induced CXCL5 accelerates inflammation and growth of prostate tumor metastases in bone.  J Clin Invest. 2;128(1):248-266, 2018.
  117. YaliXu, Milazzo JP, Somerville TD, Tarumoto U, Huang Y, Ostrander EL, Wilkinson JE, Challen GA, Vakoc CR.*A TFIID-SAGA perturbation that targets MYB and suppresses acute myeloid leukemia. Cancer Cell. 8;33(1):13-28, 2018
  118. Simon RV, Wagenblast E, Kim SY, Soto M, Khan S, Gable AL, Maceli AR, Dickopf S, Erard NR, Harrell JC, Perou CM, Wilkinson JE, Hannon GJ: Asparagine availability governs metastasis in a model of breast cancer Nature. (Feb 17, 2018).
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