hironobu-ihn
Hironobu Ihn, MD, PhD
Professor of Dermatology & Plastic Surgery

Education

1998 Ph.D University of Tokyo
1990 M.D University of Tokyo

Biography

Prof. Hironobu Ihn was born in 1964 at Kobe, Japan and graduated from University of Tokyo in 1990. He became assistant professor, Department of Dermatology, Faculty of Medicine, University of Tokyo in 1990, and worked as the research fellow in Division of Rheumatology & Immunology, Medical University of South Carolina, SC, USA between 1994 and 1997. He worked as the lecturer, Department of Dermatology, Faculty of Medicine between 2001 and 2005 and became the associate Professor, Department of Dermatology, Faculty of Medicine, University of Tokyo. He was elected as the professor & Chairman, Department of Dermatology & Plastic Surgery, Faculty Life Sciences, Kumamoto University in 2005 and became the Vice President, Kumamoto University Hospital in 2013. He obtained Japanese Society of Connective Tissue Research Award in 2001, Japanese Society of Investigative Dermatology Award in 2005, and Japan Rheumatism Foundation Award in 2006.

Research Interest

  • Dermatology & Plastic Surgery
  • Connective tissue Research
  • Cosmetic Dermatology
  • Rheumatology
  • Skin Cancer

Scientific Activities

Employment History
2013–present Vice President, Kumamoto University Hospital
2005–present Professor & Chairman, Department of Dermatology & Plastic Surgery, Faculty Life Sciences, Kumamoto University, Kumamoto, Japan
2005 Associate Professor, Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
2001-2005 2001-2005Lecturer, Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
1997-2001 Assistant, Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
1994-1997 Research Fellow, Division of Rheumatology & Immunology, Medical University of South Carolina, SC, USA
1993-1994 Assistant, Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
1992-1993 Clinical Fellow, Department of Dermatology, Kanto Rosai Hospital, Kanagawa, Japan
1991-1992 Clinical Fellow, Department of Dermatology, Kousei General Hospital, Tokyo, Japan
1990-1991 Assistant, Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
Professional Activities
  • Member of Japanese Society of Dermatology
  • Japanese Society of Investigative Dermatology
  • Japanese Society of Clinical Immunology
  • Japanese Society of connective tissue Research
  • American Academy of Immunologists
  • American Society for Matrix Biology
  • Japanese Society of Allergy
  • Japanese Society of Rheumatology
  • Japanese Society of Cosmetic Dermatology
  • Japanese Society of Psoriasis
  • Japanese Society of Skin Cancer
Honors And Awards
  • 2006 Japan Rheumatism Foundation Award
  • 2005 Japanese Society of Investigative Dermatology Award
  • 2001 Japanese Society of Connective Tissue Research Award

Publications

  1. Ohshima Y, Yajima I, Yanagishita T, Kumasaka MY, Yanagishita T, Watanabe D, Takahashi M, Inoue Y, Ihn H, Matsumoto Y, Kato M.  CD109 expression levels in human malignant melanoma. J Dermatol Sci, 57: 132-146, 2010.
  2. Matsuda M, Hoshino T, Yamashita Y, Tanaka KI, Maji D, Sato K, Adachi H, Sobue G, Ihn H, Funasaka Y, Mizushima T.  Prevention of ultraviolet B radiation-induced epidermal damage by expression of heat shock protein 70. J Biol Chem, 285: 5848-5858, 2010.
  3. Nishi H, Inoue Y, Kageshita T, Takata M, Ihn H.  The expression of human high molecular weight melanoma-associated antigen in acral lentiginous melanoma. Bioscience Trends, 4: 86-89. 2010.
  4. Akiyama M, Sakai K, Yanagi T, Fukushima S, Ihn H, Hitomi K, Shimizu H.  Transglutaminase 1 preferred substrate prptide K5 is an efficient tool in diagnosis of lamellar ichthyosis. Am J Pathol, 176: 1592-1599, 2010. 
  5. Igata T, Jinnin M, Makino T, Moriya C, Muchemwa F, Ishihara T, Ihn H.  Up-regulated type I collagen expression by the inhibition of Rac1 signaling pathway in human dermal fibroblasts. Biochem Biophys Res Commun, 393: 101-105, 2010.
  6. Hoshino T, Matsuda M, Yamashita Y, Takehara M, Fukuya M, Mineda K, Maji D, Ihn H, Adachi H, Sobue G, Funasaka Y, Mizushima T.  Supression of melanin production by expression of HSP70. J Biol Chem, 285: 13254-13263, 2010.
  7. Makino T, Jinnin M, Muchemwa F, Fukushima S, Ihn H.  Basic fibroblast growth factor stimulates the proliferation of human dermal fibroblasts via the ERK1/2 and JNK pathways. Br J Dermatol, 162: 717-723, 2010.
  8. Jinnin M, Makino T, Kajihara I, Honda N, Makino K, Ogata A, Ihn H.  Serum levels of soluble vascular endothelial growth factor receptor-2 in patients with systemic sclerosis. Br J Dermatol, 162: 751-758, 2010.
  9. Muchemwa FC, Jinnin M, Wakasugi S, Sakamoto M, Inoue Y, Ishihara T, Ihn H.  A novel COL1A1 exon 14/PDGFB fusion gene in dermatofibrosarcoma protuberans, Eur J Dermatol, 20: 390-391, 2010.
  10. Muchemwa FC, Wakasugi S, Honda Y, Ihn H.  PDGFB quantification is a useful tool in the diagnosis of dermatofibrosarcoma protuberans: a study of 10 cases. Clin Exp Dermatol, 35: 295-299, 2010.
  11. Torii H, Nakagawa H, Iizuka H, Aoyagi S, Okuyama R, Ohtsuki M, Abe M, Takamori K, Matsuba S, Terui T, Igarashi A, Kawashima M, Amagai M, Takae Y, Eto H, Ikeda S, Komine M, Saeki H, Hayakawa K, Kitami A, Watanabe H, Takehara K, Shimada S, Kitajima Y, Takigawa M, Morita A, Yamanaka K, Takahashi K, Tarutani M, Tani M, Kubota Y, Nakayama J, Ihn H.  Inflixmab monotherapy in Japanese patients with moderate-to-severe plaque psoriasis and psoriatic arthritis. A randomized, double-blind, placebo-controlled multicenter trial. J Dermatol Sci, 59: 40-49, 2010.
  12. Kato T, Inoue Y, Ishihara T, Kageshita T, Ihn H.  Amelanotic malignant melanoma where primary lesion was discovered 5 years after metastasis in the lymph node. J Dermatol, 37: 730-734, 2010.
  13. Higashi-Kuwata N, Jinnin M, Makino T, Fukushima S, Inoue Y, Muchemwa FC, Yonemura Y, Komohara Y, Takeya M, Mitsuya H, Ihn H.  Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis. Arhritis Res Ther, 12: R128 (1-10), 2010.
  14. Kawashima T, Tada Y, Asano Y, Yazawa N, Tomita M, Tamaki Z, Kubo M, Ihn H, Sugaya M, Kadono T, Tamaki K, Sato S.  Serum TARC/CCL17 levels are increased in dermatomyositis associated with interstitial lung disease. J Dermatol Sci, 60: 52-54, 2010.
  15. Honda N, Jinnin M, Kajihara I, Makino T, Fukushima T, Ihn H.  Impaired lymphangiogenesis due to excess VEGF-D/Flt-4 signaling in the skin of patients with systemic sclerosis. Br J Dermatol, 163: 776-780, 2010.
  16. Nakashima T, Jinnin M, Etoh T, Fukushima S, Masuguchi S, Maruo K, Inoue Y, Ishihara T, Ihn H.  Down-regulation of mir-424 contributes to the abnormal angiogenesis via MEK1 and cyclin E1 in senile hemangioma: its implications to therapy. PLoS One, 5: e14334, 2010.
  17. Kawashita Y, Jinnin M, Makino T, Kajihara I, Makino K, Honda N, Masuguchi S, Fukushima S, Inoue Y, Ihn H.  Circulating miR-29a levels in patients with scleroderma spectrum disorder. J Dermatol Sci, 61: 67-69, 2011.
  18. Asano Y, Ihn H, Jinnin M, Tamaki K.  Altered dynamics of TGF- receptors in scleroderma fibroblasts. Ann Rheum Dis, 70: 384-387, 2011.
  19. Moriya C, Jinnin M, Yamane K, Maruo K, Muchemwa FC, Igata T, Makino T, Fukushima S, Ihn H.  Expression of matrix metalloproteinase-13 is controlled by IL-13 via PI3K/Akt3 and PKC- in normal dermal fibroblasts. J Invest Dermatol, 131:  655-661, 2011.
  20. Kanemaru H, Fukushima S, Yamashita J, Honda N, Oyama R, Kakimoto A, Masuguchi S, Ishihara T, Inoue Y, Jinnin M, Ihn H.  Circulating microRNA-221 level in patients with malignant melanoma as a new tumor marker. J Dermatol Sci, 61: 187-193, 2011.
  21. Oyama R, Jinnin M, Kakimoto A, Kanemura H, Ichihara A, Fujisawa A, Honda N, Masuguchi S, Fukushima S, Maruo K, Ihn H.  Circulating microRNA associated with TNF signaling pathway in patients with plaque psoriasis. J Dermatol Sci, 61: 209-211, 2011.
  22. Makino K, Fukushima S, Maruo K, Egawa K, Nishimoto K, Ihn H.  Cutaneous hyalohyphomycosis by Scedosporium apiospermum in an immunocompromised patient. Mycoses, 54: 259-261, 2011.
  23. Xie Y, Jinnin M, Zhang X, Wakasugi S, Makino T, Inoue Y, Masuguchi S, Sakai K, Jinnin M, Ihn H.  Immunohistochemical characterization of the cellular infiltrate in discoid lupus erythematosus. BioScience Trends, 5: 83-88, 2011.
  24. Arakawa H, Jinnin M, Muchemwa FC, Makino T, Kajihara I, Makino K, Honda N, Sakai K, Fukushima S, Ihn H.  Adiponectin expression is decreased ininvolved skin and sera of diffuse cutaneous scleroderma patients. Exp Dermatol, 20: 764-766, 2011.
  25. Masuguchi S, Jinnin M, Fukushima S, Makino T, Sakai K, Inoue Y, Igata T, Ihn H.  The expression of HER-2 in extramammary Paget’s disease. BioScience Trends, 5: 151-155, 2011.
  26. Kuwata N, Makino T, Inoue Y, Ihn H.  Expression pattern of VEGF-1, -2, -3, and D2-40 protein in the skin of patients with systemic sclerosis. Eur J Dermatol, 21: 490-494, 2011.
  27. Maekawa T, Jinnin M, Ihn H.  The expression levels of thrombospondin-1 in dermatofibroma and dermatofibrosarcoma protuberans. Eur J Dermatol, 21: 534-538, 2011.
  28. Ichihara A, Jinnin M, Yamane K, Fujisawa A, Sakai K, Masuguchi S, Fukushima S, Maruo K, Ihn H.  micro-RNA mediated keratinocyte hyperproliferation in psoriasis. Br J Dermatol, 165: 1003-1010, 2011.
  29. Yamada M, Sakai K, Hayashi M, Hozumi Y, Abe Y, Kawaguchi M, Ihn H, Suzuki T. Oculocutaneous Albinism Type 3: A Japanese girl with novel mutations in TYRP1 gene. J Dermatol Sci, 64: 217-222, 2011.
  30. Jinnin M, Fukushima S, Masuguchi S, Tanaka H, Kawashita Y, Ishihara T, Ihn H.  Evaluation of usefulness of 3D views for clinical photography. BioScience Trends, 5: 211-216, 2011.
  31. Aoi J, Endo M, Kadomatsu T, Miyata K, Nakano M, Horiguchi H, Ogata A, Odagiri H, Yano M, Araki K, Jinnin M, Ito T, Hirakawa S, Ihn H, Oike Y. Angiopoietin-like protein 2 is an important facilitator of inflammatory carcinogenesis and metastasis. Cancer Res, 71：7502-7512, 2011.
  32. Kajihara I, Jinnin M, Makino T, Toihata-Yonemitsu A, Sakai K, Masuguchi S, Fukushima S, Ihn H.  Clinical significance of cobble stone appearance on the skin of patients with systemic sclerosis. J Eur Acad Dermatol Venereol, 26: 123-125, 2012.
  33. Hasegawa M, Asano Y, Endo H, Fujimoto M, Goto D, Ihn H, Inoue K, Ishikawa O, Kawaguchi Y, Kuwana M, Muro Y, Ogawa F, Sasaki T, Takahashi H, Tanaka S, Takehara K, Sato S.  Investigation of prognostic factors for skin sclerosis and lung function in Japanese patients with systemic sclerosis: a multicenter prospective observational study. Rheumatology, 51：129-133, 2012.
  34. Namikawa K, Yamazaki N, Nakai Y, Ihn H, Tomita Y, Uhara H, Takenouchi T, Kiyohara Y, Moroi Y, Yamamoto Y, Otsuka F, Kamiya H, Iizuka H, Hatta N, Kadono T.  Prediction of additional lymph node positivity and clinical outcome of micrometastases in sentinel lymph nodes in cutaneous melanoma: A multi-institutional study of 450 patients in Japan. J Dermatol, 39: 130-137, 2012.
  35. Tomita M, Kadono T, Yazawa N, Kawashima T, Tamaki Z, Ashida R, Ohmatsu H, Asano Y, Sugaya M, Kubo M, Ihn H, Tamaki K, Sato S.  Serum levels of soluble CD21 in patients with systemic sclerosis. Rheumatol Int, 32: 317-321, 2012.
  36. Nakayama W, Jinnin M, Makino K, Kajihara I, Makino T, Fukushima S, Inoue Y, Ihn H.  Serum levels of soluble CD163 in patients with systemic sclerosis. Rheumatol Int, 32: 403-407, 2012.
  37. Kajihara I, Jinnin M, Yamane K, Makino T, Honda N, Igata T, Masuguchi S, Fukushima S, Okamoto Y, Hasegawa M, Fujimoto M, Ihn H.  Increased accumulation of thrombospondin-2 due to low degradation activity stimulates type I collagen expression in scleroderma fibroblasts. Am J Pathol, 180: 703-714, 2012.
  38. Kudo K, Fukushima S, Masuguchi S, Sakai K, Jinnin M, Ihn H.  Cutaneous type adult T-cell leukemia/lymphoma successfully treated with narrow-band ultraviolet B phototherapy. Clin Exp Dermatol, 37: 183-184, 2012.
  39. Ogata A, Endo M, Aoi J, Takahashi O, Kadomatsu T, Miyata K, Tian Z, Jinnin M, Fukushima S, Ihn H, Oike Y.  The role of angiopoietin-like protein 2 in pathogenesis of dermatomyositis. Biochem Biophys Res Commun, 418: 494-499, 2012.
  40. Makino K, Jinnin M, Kajihara I, Honda N, Sakai K, Masuguchi S, Fukushima S, Inoue Y, Ihn H.  Circulating miR-142-3p levels in patients with systemic sclerosis. Clin Exp Dermatol, 37: 34-39, 2012.
  41. Honda N, Jinnin M, Kajiwara I, Makino T, Makino K, Masuguchi S, Fukushima S, Okamoto Y, Hasegawa M, Fujimoto M, Ihn H.  TGF--mediated down-regulation of microRNA-196a contributes to the constitutive up-regulated type I collagen expression in scleroderma dermal fibroblasts. J Immunol, 188: 3323-3331, 2012.
  42. Ichihara A, Jinnin M, Oyama R, Yamane K, Fujisawa A, Sakai K, Masuguchi S, Fukushima S, Maruo K, Ihn H.  Increased serum levels of miR-1266 in patients with psoriasis vulgaris. Eur J Dermatol, 22: 68-71, 2012.
  43. Nakajima T, Jinnin M, Honda N, Kajihara I, Makino T, Masuguchi S, Fukushima S, Okamoto Y, Hasegawa M, Fujimoto M, Ihn H.  Impaired IL-17 signaling pathway contributes to the increased collagen expression in scleroderma fibroblasts. J Immunol, 188: 3573-3583, 2012.
  44. Oshikawa Y, Fukushima S, Miyake T, Kawaguchi T, Motomura K, Nakashima Y, Nakamura K, Jinnin M, Ihn H.  Photosensitivity and acute liver insufficiency in late-onset erythropoietic protoporphyria with a chromosome 18q abnormality. Case Rep Dermatol 4: 14-149, 2012.
  45. Kajihara I, Jinnin M, Makino T, Masuguchi S, Sakai K, Fukushima S, Maruo K, Inoue Y, Ihn H.  Overexpression of hepatocyte growth factor receptor in scleroderma dermal fibroblasts is caused by autocrine transforming growth factor signaling. BioScience Trends, 6: 136-142, 2012..
  46. Sing T, Jinnin M, Yamane K, Honda N, Makino K, Kajihara I, Makino T, Sakai K, Mashuguchi S, Fukushima S, Ihn H.  microR-92a expression in the sera and dermal fibroblasts increases in patients with scleroderma. Rheumatology, 51: 1550-1556, 2012.
  47. Yamashita J, Fukushima S, Jinnin M, Honda N, Makino K, Sakai K, Masuguchi S, Inoue Y, Ihn H.  Kinase family member 20A as is a novel melanoma-associated antigen. Acta Derm Venereol, 92: 593-597, 2012.
  48. Nakayama W, Jinnin M, Makino K, Kajihara I, Makino T, Fukushima S, Sakai k, Inoue Y, Ihn H.  CD163 expression is increased in the involved skin and sera of patients with systemic lupus erythematosus. Eur J Dermatol, 22：512-517, 2012.
  49. Hayashi Y, Jinnin M, Makino T, Kajihara I, Makino K, Honda N, Nakayama W, Inoue K, Fukushima S, Ihn H.  Serum angiopoietin-like protein 3 concentrations in rheumatic diserases. Eur J Dermatol, 22: 500-504, 2012.
  50. Takashio S, Izumiya Y, Jinnin M, Yamamuro M, Kojima S, Ihn H, Ogawa H.  Diagnostic and prognostic value of subcutaneous tissue biopsy in patients with cardiac amyloidosis. Am J Cardiol, 110: 1507-1511, 2012.
  51. Niimori D, Kawano R, Felemban A, Niimori-Kita K, Tanaka H, Ihn H, Ohta K.  Tsukushi controls the hair cycle by regulating TGF-1 signaling. Dev Biol, 372: 81-87, 2012.
  52. Aoi J, Ogata A, Makino T, Sakai K, Masuguchi S, Fukushima S, Jinnin M, Inoue Y, Ihn H.  Case of blastic plasmaytoid dendritic cell neoplasm. J Dermatol, 39: 1066-1067, 2012.
  53. Kuwahara A, Jinnin M, Makino T, Kajihara I, Makino K, Honda N, Nakayama W, Inoue K, Fukushima S, Ihn H.  Serum concentration of angiogenin in patients with rheumatic diseases. BioScience Trends, 6: 229-233, 2012.
  54. Honda N, Jinnin M, Kira-Etoh T, Makino K, Kajihara I, Makino T, Fukushima S, Inoue Y, Okamoto Y, Hasegawa M, Fujimoto M, Ihn H.  miR-150 down-regulation contributes to the constitutive type I collagen overexpression in scleroderma dermal fibroblasts via the induction of integrin 3. Am J Pathol, 182: 206-216, 2013.
  55. Yamashita J, Iwakiri T, Fukushima S, Jinnin M, Miyashita A, Hamasaki T, Makino T, Aoi J, Masuguchi S, Inoue Y, Ihn H.  The rs2910164 G>C polymorphism in microRNA-146a is associated with the incidence of malignant melanoma. Melanoma Res, 23: 13-20, 2013.
  56. Sakoguchi A, Jinnin M, Makino T, Kajihara I, Makino K, Honda N, Nakayama W, Inoue K, Fukushima S, Ihn H.  The miR-146a rs2910164G/C polymorphism is associated with telangiectasia in systemic sclerosis. Clin Exp Dermatol, 38: 99-100, 2013.
  57. Etoh M, Jinnin M, Makino K, Yamane K, Nakayama W, Aoi J, Honda N, Kajihara I, Makino T, Fukushima S, Ihn H.  microRNA-7 down-regulation mediates excess collagen expression in localized scleroderma. Arch Dermatol Res, 305: 9-15, 2013.
  58. Yamane K, Jinnin M, Etoh T, Kobayashi Y, Shimozono N, Fukushima S, Masuguchi S, Maruo K, Inoue Y, Ishihara T, Aoi J, Oike Y, Ihn H.  Down-regulation of miR-124/ -214 in cutaneous squamous cell carcinoma mediates abnormal cell proliferation via the induction of ERK. J Mol Med, 91: 69-81, 2013.  
  59. Kudo H, Jinnin M, Yamane K, Makino T, Kajihara I, Makino K, Honda N, Nakayama W, Fukushima S, Ihn H.  Intravenous immunoglobulin treatment recovers the down-regulatied levels of Th1 cytokines in the sera and skin of scleroderma patients. J Dermatol Sci, 69: 77-80, 2013.
  60. Makino K, Jinnin M, Aoi J, Hirano A, Kajihara I, Makino T, Sakai K, Fukushima S, Inoue Y, Ihn H.  Diccoidin domain receptor 2 –micro RNA 196a -mediated negative feedback against excess type I collagen expression is impaired in scleroderma dermal fibroblasts. J Invest Dermatol, 133: 110-119, 2013.
  61. Kanemura H, Fukushima S, Yamashita J, Jinnin M, Sakai K, Masuguchi M, Aoi J, Makino T, Inoue Y, Ihn H.  Serum epidermal growth factor receptor levels in patients with malignant melanoma. Clin Exp Dermatol, 38: 172-177, 2013.
  62. Shimada S, Jinnin M, Ogata A, Makino T, Kajihara I, Makino K, Honda N, Nakayama W, Inoue K, Fukushima S, Ihn H.  Serum miR-21 levels in patients with dermatomyositis. Clin Exp Rheumatol, 31: 161-162, 2013.
  63. Maekawa T, Jinnin M, Ohtsuki M, Ihn H.  Serum levels of interleukin-1 in patients with systemic sclerosis. J Dermatol, 40: 98-101, 2013.
  64. Matsuda M, Hoshino T, Yamakawa N, Tahara K, Adachi H, Sobue G, Maji D, Ihn H, Mizushima T.  Suppresion of UV-induced wrinkle formation by induction of HSP70 expression in mice. J Invest Dermatol, 133: 919-928, 2013.
  65. Honda Y, Tanigawa H, Harada M, Fukushima S, Masuguchi S, Ishihara T, Ihn H, Iyama K.  Hidradenocarcinoma showing prominent mucinous and squamous differentiation and associated with pgetoid cells. J Cutan Pathol, 40: 503-508, 2013.
  66. Aoi J, Makino K, Sakai K, Masuguchi S, Fukushima S, Jinnin M, Inoue Y, Koga H, Hashimoto T, Ihn H.  Case of paraneoplastic pemphigus with follicular lymphoma treated with rituximab. J Dermatol, 40: 285-256, 2013.
  67. Makino K, Jinnin M, Hirano A, Yamane K, Eto M, Kusano T, Honda N, Kajihara K, Makino T, Sakai K, Masuguchi S, Fukushima S, Ihn H.  The down-regulation of microRNA let-7a contributes to the excessive expression of type I collagen in systemic and localized scleroderma. J Immunol, 190: 3905-3915, 2013.
  68. Inoue K, Jinnin M, Yamane K, Makino T, Kajihara I, Makino K, Honda N, Nakayama W, Fukushima S, Ihn H.  Down-regulation of miR-223 contributes to the formation of Gottron’s eruption in dermatomyositis via the induction of PKC. Eur J Dermatol, 23: 160-167, 2013.
  69. Kajihara I, Ichihara A, Higo J, Kidou M, Ihn H.  Pyodermatitis vegetans associated with multiple myeloma. J Dermatol, 40: 222-223, 2013.
  70. Oshikawa Y, Jinnin M, Makino T, Kajihara I, Makino K,Honda N, Nakayama W, Inoue K, Fukushima S, Ihn H.  Decreased miR-7 expression in the skin and sera of patients with dermatomyositis. Acta Derm Venereol, 93: 273-276, 2013.
  71. Koba S, Jinnin M, Inoue K, Nakayama W, Honda N, Makino K, Kajihara I, Makino T, Fukushima S, Ihn H.  Expression analysis of multiple microRNAs in each patient with scleroderma Exp Dermatol, 22: 489-491, 2013.
  72. Kajihara I, Jinnin M, Honda N, Makino K, Makino T, Masuguchi S, Sakai K, Fukushima S, Inoue Y, Ihn H.  Scleroderma dermal fibroblasts overexpress vascular endothelial growth factor due to autocrine transforming growth factor  signaling. Mod Rheumatol, 23: 516-524, 2013.
  73. Jinnin M, Fukushima S, Inoue Y, Ihn H.  Geographical flushing of the children’s face: A new clinical entity. Case Rep Dermatol Med, 2013: 802130. 2013.
  74. Takehara K, Ihn H, Sato S.  A randomized, double-blind, placebo-controlled trial: intravenous immunoglobulin treatment in patients with diffuse cutaneous systemic sclerosis. Clin Exp Rheum, 31: 151-156, 2013.
  75. Inoue K, Jinnin M, Hara Y, Makino K, Kajihara I, Makino T, Sakai K, Fukushima S, Inoue Y, Ihn H. Serum levels of tenascin-C in collagen diseases. J Dermatol, 40: 715-719, 2013.
  76. Kanemaru H, Makino T, Jinnin M, Yonemitsu A, Makino K, Ihn H.  Case of neuro-Behcet’s disease successfully maintained a remission using infliximab for 2 years. J Dermatol, .40: 632-4, 2013.
  77. Kogushi-Nishi M, Jinnin M, Kobayashi Y, Muchemwa FC, Hirano A, Makino T, Fukushima S, Masuguchi S, Ihsihara T, Ihn H.  Role of c-Jun N-termainal kinase isoforms in the cellular activity of melanoma cell lines. Clin Exp Dermatol, 38: 890-896, 2013.
  78. Yamada S, Makino T, Jinnin M, Sakai K, Fukushima S, Inoue Y, Ihn H.  Association of linear IgA bullous disease with ulcerative colitis: A case of successful treatment with infliximab. Dermatology, 227: 295-298, 2013.
  79. Hirao H, Jinnin M, Ichihara A, Fujisawa A, Makino K, Kajihara I, Sakai K, Fukushima S, Inoue Y, Ihn H.  Detection of hair root miR-19a as a novel diagnostic marker for psoriasis. Eur J Dermatol, 23: 807-811, 2013.
  80. Takemoto R, Jinnin M, Wang Z, Kudo H, Inoue K, Nakayama W, Ichihara A, Igata T, Kajihara I, Fukushima S, Ihn H.  Hair miR-29a levels are decreased in patients with scleroderma. Exp Dermatol, 22: 832-849, 2013.
  81. Wang Z, Jinnin M, Kudo H, Inoue K, Nakayama W, Honda N, Makino K, Kajihara I, Fukushima S, Inoue Y, Ihn H.  Detection of hair-microRNAs as the novel potent biomarker: Evaluation of the usefulness for the diagnosis of scleroderma. J Dermatol Sci, 72: 134-141, 2013.
  82. Hasegawa M, Asano Y, Endo H, Fujimoto M, Goto D, Ihn H, Inoue K, Ishikawa O, Kawaguchi Y, Kuwana M, Ogawa F, Takahashi H, Tanaka S, Sato S, Takehara K.  Serum chemokine levels as prognostic markers in patients with early systemic sclerosis: a multicentre, prospective, observational study. Mod Rheumatol, 23: 1076-1084, 2013.
  83. Fujisawa A, Egawa K, Honda Y, Kuroki M, Jinnin M, Ihn H.  CEA (carcinoembryonic antigen) and CEACAM6 (CEA-related cell adhesion molecule 6) are expressed in psoriasis vulgaris. The Open Dermatol J, 7: 47-52, 2013.
  84. Mizutani H, Fukushima S, Masuguchi S, Yamashita J, Miyashita A, Nakahara S, Aoi J, Inoue Y, Jinnin M, Ihn H.  Serum levels of leptin receptor in patients with malignant melanoma as a new tumor marker. Exp Dermatol, 22: 748-749, 2013.
  85. Shiiyama R, Fukushima S, Jinnin M, Yamashita J, Miyashita A, Nakahara S, Kogi A, Aoi J, Masuguchi S, Inoue Y, Ihn H.  Sensitive detection of melanoma metastasis utilizing circulating microRNA expression profiles. Melanoma Res, 23: 366-372, 2013.
  86. Fukushima S, Morita E, Tanioka M, Miyachi Y, Murakami Y, Matsunaka H, Ihn H.  Clinical evaluation of moisturizers with physiological analysis of stratum corneum TARC and TSLP. J Cosmetics, Dermatological Sciences and Applications, 4: 37-43, 2014.
  87. Sugaya M, Tokura Y, Hamada T, Tsuboi R, Moroi Y, Nakahara T, Amano M, Ishida S, Watanabe D, Tani M, Ihn H, Aoi J, Iwatsuki K.  Phase II study of i.v. interferon- in Japanese patient s with mycosis fungoides. J Dermatol, 41: 50-56, 2014.
  88. Inoue Y, Menzies SW, Fukushima S, Nishi-Kogushi H, Miyashita A, Masuguchi S, Muchemwa F, Kageshita T, Ihn H.  Dots/ globules on dermoscopy in nail-apparatus melanoma. Int J Dermatol, 53: 88-92, 2014.
  89. Hasegawa M, Asano Y, Endo H, Fujimoto M, Goto D, Ihn H, Inoue K, Ishikawa O, Kawaguchi Y, Kuwana M, Ogawa F, Takahashi H, Tanaka S, Sato S, Takehara K.  Serum adhesion molecule levels as prognostic markers in patients with early systemic sclerosis: a multicenter, prospective, observational study. PLoS One, 9: e88150, 2014.
  90. Kajihara I, Jinnin M, Yamada S, Ichihara A, Makino T, Igata T, Masuguchi S, Fukushima S, Ihn H.  Successful treatment of skin fistulas in systemic sclerosis patients with the combination of topical negative pressure therapy and split-thickness skin grafting. Mod Rheumatol, 24: 374-376, 2014.
  91. Aoi J, Endo M, Kadomatsu T, Miyata K, Ogata A, Horiguchi H, Odagiri H, Matsuda T, Fukushima S, Jinnin M, Hirakawa S, Sawa T, Akaike T, Ihn H, Oike Y.  Angiopoietin-like protein 2 accelerates carcinogenesis by activating chronic inflammation and oxidative stress. Mol Cancer Res, 12: 239-249, 2014.
  92. Kanemaru H, Jinnin M, Asao A, Ichihara A, Makino K, Kajihara I, Fujisawa A, Fukushima S, Ihn H.  A case of psoriasis accompanied by arthritis after delivery. BioScience Trends, 8: 64-67, 2014.
  93. Okada Y, Jinnin M, Makino T, Kajihara I, Makino K, Honda N, Nakayama W, Inoue K, Fukushima S, Ihn H.  MIRSNP rs2910164 of miR-146a is associated with the muscle involvement in polymyositis/ dermatomyositis. Int J Dermatol, 53: 300-304, 2014.
  94. Ikeda I, Ohno T, Ohno H, Miyazaki Y, Nishimoto K, Makino T, Ihn H.  Case of Fusarium paronychia successfully treated with occulisive dressing of antifungal cream. J Dermatol, 41: 340-342, 2014..
  95. Ichihara A, Wang Z, Jinnin M, Izono Y, Shimozono N, Yamane K, Fujisawa A, Moriya C, Fukushima S, Inoue Y, Ihn H.  Up-regulation of miR-18a contributes to the epidermal necrolysis in severe drug eruptions. J Allergy Clin Immunol, 133: 1065-1074, 2014.
  96. Koga Y, Jinnin M, Ichihara A, Fujisawa A, Moriya C, Sakai K, Fukushima S, Inoue Y, Ihn H.  Analysis of expression pattern of serum microRNA levels in patients with psoriasis. J Dermatol Sci, 74: 170-171, 2014.
  97. Kajihara I, Jinnin M, Harada M, Makino K, Honda N, Makino T, Igata T, Masuguchi S, Fukushima S, Ihn H.  miR-205 down-regulation promotes proliferation of dermatofibrosarcoma protuberans tumor cells by regulating LRP-1 and ERK phosphorylation. Arch Dermatol Res, 306: 367-374, 2014.
  98. Tamaki Z, Asano Y, Kubo M, Ihn H, Tada Y, Sugaya M, Kadono T, Sato S.  Effects of the immunosuppressant rapamycin on the expression of human 2(I) collagen and matrix metalloproteinase 1 genes in scleroderma dermal fibroblasts. J Dermatol Sci, 74: 251-259, 2014.
  99. Tsuru Y, Jinnin M, Ichihara A, Fujisawa A, Moriya C, Sakai K, Fukushima S, Ihn H.  miR-424 levels in hair shaft are increased in psoriasis patients. J Dermatol, 41: 382-385, 2014.
  100. Ichihara A, Jinnin M, Fukushima S, Inoue Y, Ihn H.  Case of disseminated cutaneous Mycobacterium chelonae infection mimicking cutaneous vasculitis. J Dermatol, 41: 414-417, 2014.
  101. Makino K, Jinnin M, Aoi J, Kajihara I, Makino T, Fukushima S, Sakai K, Nakayama K, Emoto N, Yanagisawa M, Ihn H.  Knockout of endothelial cell-derived endothelin-1 attenuates skin fibrosis but accelerate cutaneous wound healing. PLoS One, 9: e97972, 2014.
  102. Kudo H, Jinnin M, Asano Y, Trojanowska M, Nakayama W, Inoue K, Honda N, Kajihara I, Makino K, Fukushima S, Ihn H.  Decreased IL-20 expression in scleroderma skin contributes to cutaneous fibrosis. Arthritis Rheumatol, 65: 1636-1647, 2014.
  103. Fukushima S, Masuguchi S, Igata T, Harada M, Aoi J, Miyashita A, Nakahara S, Inoue Y, Jinnin M, Shiraishi S, Yamashita Y, Ishihara T, Ihn H.  Evaluation of sentinel node biopsy for cutaneous squamous cell carcinoma. J Dermatol, 41: 539-541, 2014.
  104. Kajihara I, Makino K, Ichihara A, Fukushima S, Jinnin M, Hirooka S, Kojima K, Kourogi H, Ihn H.  Immunoglobulin G4-related disease in a psoriasis vulgaris patient treated with ustekinumab. J Dermatol, 41: 670-671, 2014..
  105. Makino K, Jinnin M, Makino T, Kajihara I, Fukushima S, Inoue Y, Ihn H.  Serum levels of soluble carbonic anhydrase IX are decreased in patients with diffuse cutaneous systemic sclerosis compared to those with limited cutaneous systemic sclerosis. Biosci Trends, 8: 144-148, 2014.
  106. Kuriyama H, Jinnin M, Kanemaru H, Ichihara A, Fujisawa A, Moriya C, Fukushima S, Ihn H.  Clincal significance of serum vascular endothelial-cadherin levels in inflammatory skin diseases. Ann Dermatol, 26: 536-538, 2014..
  107. Asano Y, Ihn H, Jinnin M, Tamaki Z, Tamaki K, Sato S.  Serum levels of matrix metalloproteinase-13 in patients with eosinophilic fasciitis. J Dermatol, 41: 746-748, 2014..
  108. Miyashita A, Fukushima S, Makino T, Yoshino Y, Yamashita J, Honda N, Aoi J, ,Ichihara A, Jinnin M, Inoue Y, Ihn H.  The proportion of lymphocytic inflammation with CD123-positive cells in lupus erythematosus profundus predict a clinical response to treatment. Acta Derm Venereol, 94: 563-567, 2014.
  109. Kobayashi D, Hirayama M, Komohara Y, Mizuguchi S, Wilson Morifuji M, Ihn H, Takeya M, Kuramochi A, Araki N.  Transcriptionally controlled tumor protein is a novel biologic target for neurofibromatosis type I (NF-1) -associated tumors. J Biol Chem, 289: 26314-26326, 2014.
  110. Makino T, Jinnin M, Etoh M, Yamane K, Kajihara I, Makino K, Ichihara A, Igata T, Sakai K, Fukushima S, Ihn H.  Down-regulation of microRNA-196a in the sera and involved skin of localized scleroderma patients. Eur J Dermatol, 24: 470-476, 2014.
  111. Ohyoshi Y, Makino T, Jinnin M, Nakayama W, Fukushima S, Inoue Y, Ihn H.  Serum levels of leptin receptor in patients with systemic sclerosis. Intractable Rare Dis Res, 2: 55-58, 2014.
  112. Aoi J, Nagatomo E, Masuguchi S, Fukushima S, Jinnin M, Ihn H.  A simple and effective reconstructive technique for repairing defects of the upper lip using a hatchet flap. J Dermatol, 41: 1025-1026, 2014.
  113. Kubo Y, Jono T, Makino T, Sakai K, Masuguchi S, Fukushima S, Jinnin, Inoue Y, Ihn H.  A case of anaplastic large cell lymphoma of skeletal muscle. J Dermatol, 41: 999-1002, 2014.
  114. Aoi J, Masuguchi S, Fukushima S, Jinnin M, Ihn H.  Aesthethic reconstruction of defects in the lateral side wall of the nose using a local V-Y flap. J Dermatol, 41: 1026-1028, 2014.
  115. Kusumoto S, Kajihara I, Nagatomo E, Makino K, Ichihara A, Aoi J, Johno T, Makino T, Fukushima S, Jinnin M, Ihn H.  Increased CCL22 expression in psoriatic skin predicts a good response to infliximab therapy. Br J Dermatol, 171: 1259-1261, 2014.
  116. Sakoguchi A, Nakayama W, Jinnin M, Wang Z, Yamane K, Aoi J, Makino K, Kajihara I, Ichihara A, Makino T, Fukushima S, Sakai K, Inoue Y, Ihn H.  The expression profile of the toll-like receptor family in scleroderma dermal fibroblasts. Clin Exp Rheumatol, 32: S4-S9, 2014.
  117. Niimori D, Kawano R, Niimori-Kita K, Ihn H, Ohta K.  Tsukushi is involved in the wound healing by regulating the expression of cytokines and growth factors. J Cell Commun Signal, 8: 173-177, 2014.
  118. Jinnin M, Miyata K, Hiruma M, Ihn H.  Clinical features of 80 cases with tinea faciei treated at a rural clinic in Japana. Drug Discov Ther 8: 245-248, 2014.
  119. Tanaka T, Tanida Y, Hayashi T, Motoyama K, Higashi T, Kaneko S, Ishitsuka Y, Irie T, Kaneko T, Okajima M, Ihn H, Arima H.  Potential use of a novel polysaccharide as a skin care material for atopic dermatitis. IFSCC Proceeding 2014.
  120. Miyamoto Y, Watanabe M, Ishimoto T, Baba Y, Iwagami S, Sakamoto Y, Yoshida N, Masuguchi S, Ihn H, Baba H.  Fascia lata onlay patch for repairing infected incisional hernias. Surg Today, 45：121−124, 2015.
  121. Inada T, Fukushima S, Murai M, Jinnin M, Miyashita A, Nakahara S, Yamashita J, Aoi J, Msuguchi S, Ihn H.  Hair shaft microRNA-221 levels as a new tumor marker of malignant melanoma. J Dermatol, 42: 198-201, 2015.
  122. Kajihara I, Kanemaru H, Miyake T, Aoi J, Masuguchi S, Fuksuhima S, Jinnin M, Inoue Y, Ihn H.  Combination chemotherapy with S-1 and docetaxel for cutaneous angiosarcoma resistant to paclitaxel. Drug Discov Ther 9: 75-77, 2015.
  123. Soga M, Ishitsuka Y, Hamasaki M, Yoneda K, Furuya H, Matsuo M, Ihn H, Fusaki N, Nakamura K, Nakagata M, Endo F, Irie T, Era T.  HPGCD outperforms HPBCD as a potential treatment for Niemann-Pick diseadse type C during disease modeling with iPS cells. Stem Cells, 34: 1075-1088, 2015.
  124. Noguchi H, Hiruma M, Inoue Y, Miyata K, Tanaka M, Ihn H.  Tinea nigra showing parallel ridge pattern on dermoscopy. J Dermatol, 42: 518-520, 2015.
  125. Kumasasa MY, Yajima I, Iida M, Takahashi H, Inoue Y, Fukushima S, Ihn H, Takeda K, Naito Y, Yoshikawa T, Kato M.  Correlated expression levels of endothelin receptor B and Plexin C1 in melanoma. Am J Cancer Res, 5: 1117-1123, 2015.
  126. Kanemaru H, Kajihara I, Yamanaka K, Igata T, Makino T, Masuguchi S, Fukushima S, Jinnin M, Ihn H.  Platelet-rich plasma therapy is effective for the treatment of refractory skin ulcers in patients with systemic sclerosis. Mod Rheumatol, 25: 660-661, 2015.
  127. Sawamura S, Kajihara I, Ichihara A, Fukushima S, Jinnin M, Yamaguchi E, Kohrogi H, Ihn H.  Crizotinib-associated erythema multiforme in a lung cancer patient. Drug Discov Ther, 9: 142-143, 2015.
  128. Nakamura K, Nakatsuka N, Jinnin M, Makino T, Kajihara I, Makino K, Honda N, Inoue K, Fukushima S, Ihn H.  Serum concentrations of Flt-3 ligand in rheumatic diseases. Biosci Trends, 9: 342-349, 2015.
  129. Shimozono N, Jinnin M, Masuzawa M, Masuzawa M, Wang Z, Hirano A, Tomizawa Y, Etoh-Kira T, Kajihara I, Harada M, Fukushima S, Ihn H.  NUP160-SLC43A3 is a novel recurrent fusion oncogene in angiosarcoma. Cancer Res, 75: 4458-4465, 2015.
  130. Kudo H, Wang Z, Jinnin M, Nakayama W, Inoue K, Honda N, Nakashima T, Kajihara I, Makino K, Makino T, Fukushima S, Ihn H.  EBI3 downregulation contributes to type I collagen overexpression in scleroderma skin. J Immunol, 195: 3565-3573, 2015.
  131. Wang Z, Jinnin M, Kobayashi Y, Kudo H, Inoue K, Nakayama W, Honda H, Makino K, Kajihara I, Makino T, Fukushima S, Ihn H.  Mice overexpressing integrin v in fibroblasts exhibit dermal thinning of the skin. J Dermatol Sci, 79: 268-278, 2015.
  132. Kajihara I, Maeda S, Yamada S, Izumi K, Masuguchi S, Fukushima S, Jinnin M, Ihn H.  Biweekly gemcitabine therapy induces complete remmision in cutaneous angiosarcoma resistant to multiple anticancer drugs. J Dermatol, 42: 1197-1198, 2015.
  133. Sato A, Ichihara A, Jinnin M, Fukushima S, Ihn H.  Serum miR-124 up-regulation as a disease marker of toxic epidermal necrolysis. Eur J Dermatol, 25: 457-462, 2015.
  134. Saito Y, Ohnishi K, Miyashita A, Nakahara S, Fujiwara Y, Horiad H, Motoshima T, Fukushima S, Jinnin M, Ihn H, Takeya M, Komohara Y, Prognostic isignificance of CD169+ lymph node sinus macrophages in patients with malignant melanoma. Cancer Immunol Res, 3: 1356-1363, 2015.
  135. Miyashita A, Fukushima S, Nakahara S, Yamashita J, Tokuzumi A, Aoi J, Ichihara A, Kanemaru H, Jinnin M, Ihn H.  Investigation of FOXM1 as a potential new  target for melanoma. PLoS One, 10: e0144241, 2015.
  136. Fukushima S, Motoyama K, Tanida Y, Higashi T, Ishitsuka Y, Kondo Y, Irie T, Tanaka T, Ihn H, Arima H.  Clinical evaluation of novel natural polysaccharides Sacran as a skincare material for atopic dermatitis patients. J Cosmetics, Dermatological Sciences and Applications, 6: 9-18, 2016.
  137. Ihn H.  Fibrosis: Overview. Systemic sclerosis basic and Translational Research 1-20, 2016 (Springer)
  138. Ichigozaki Y, Fukushima S, Jinnin M, Miyashita A, Nakahara S, Tokuzumi A, Yamashita J, Kajihara I, Aoi J, Masuguchi S, Wang Z, Ihn H. Serum long non-coding RNA, snoRNA host gene 5 level as a new tumor marker of malignant melanoma. Exp Dermatol, 25: 67-69, 2016.
  139. Goto Y, Yajima I, Kumasaka M, Ohgami N, Tanaka A, Tsuzuki T, Inoue Y, Fukushima S, Ihn H, Kyoya M, Ohashi H, Kawakami T, Bennet DC, Kato M. Transcription factor LSF (TFCP2) inhibits melanoma growth. Oncotarget, 7: 2379-2390, 2016.
  140. Wang Z, Jinnin M, Nakamura K, Harada M, Kudo H, Nakayama W, Inoue K, Nakashima T, Honda N, Fukushima S, Ihn H.  Long non-coding RNA TSIX is up-regulated in scleroderma dermal fibroblasts and controls collagen mRNA stabilization. Exp Dermatol, 25: 131-136, 2016.
  141. Miyashita A, Fukushima S, Nakahara S, Kubo Y, Tokuzumi A, Yamashita J, Aoi J, Haruta M, Senju S, Nishimura Y, Jinnin M, Ihn H.  Immunotherapy against metastatic melanoma with human iPS cell-derived myeloid cell lines producing type I interferons. Cancer Immunol Res, 4: 248-258, 2016.
  142. Yamada S, Kajihara I, Johno T, Fukushima S, Jinnin M, Masunaga A, Kohrogi H, Ihn H.  Symptomless pulmonary cryptococcosis in a psoriatic arthritis patient during infliximab therapy. Ann Dermatol, 28: 269-270, 2016.
  143. Inoue Y, Hasegawa M, Maekawa T, Le Pavoux A, Asano Y, Abe M, Ishii T, Ito T, Isei T, Imafuku S, Irisawa R, Ohtsuka M, Ohtsuka M, Ogawa F, Kadono T, Kodera M, Kawakami T, Kawaguchi M, Kukino R, Kono T, Sakai K, Takahara M, Tanioka M, Nakanishi T, Nakamura Y, Hashimoto A, Hayashi M, Fujimoto M, Fujiwara H, Matsuo K, Madokoro N, Yamasaki O, Yoshino Y, Tachibana T, Ihn H.  The woud/ burn guidelines – 1: Wounds in general. J Dermatol, 43: 357-375, 2016.
  144. Tachibana T, Imafuku S, Irisawa R, Ohtsuka M, Kadono T, Fujiwara H, Asano Y, Abe M, Ishii T, Isei T, Ito T, Inoue Y, Ohtsuka M, Ogawa F, Kodera M, Kawakami T, Kawaguchi M, Kukino R, Kono T, Sakai K, Takahara M, Tanioka M, Nakanishi T, Nakamura Y, Hashimoto A, Hasegawa M, Hayashi M, Fujimoto M, Maekawa T, Matsuo K, Madokoro N, Yamasaki O, Yoshino Y, Le Pavoux A, Ihn H. The woud/ burn guidelines – 2: Guidelines for the diagnosis and treatment for pressure ulcers. J Dermatol, 43: 469-506, 2016.
  145. Isei T, Abe M, Nakanishi T, Matsuo K, Yamasaki O, Asano Y, Ishii T, Ito T, Inoue Y, Imafuku S, Irisawa R, Ohtsuka M, Ohtsuka M, Ogawa F, Kadono T, Kodera M, Kawakami T, Kawaguchi M, Kukino R, Kono T, Sakai K, Takahara M, Tanioka M, Nakamura Y, Hashimoto A, Hasegawa M, Hayashi M, Fujimoto M, Fujiwara H, Maekawa T, Madokoro N, Yoshino Y, Le Pavoux A, Tachibana T, Ihn H. The woud/ burn guidelines – 3: Guidelines for the diagnosis and treatment for diabetic ulcer/gangrene. J Dermatol, 43: 591-619, 2016.
  146. Fujimoto M, Asano Y, Ishii T, Ogawa F, Kawakami T, Kodera M, Abe M, Isei T, Ito T, Inoue Y, Imafuku S, Irisawa R, Ohtsuka M, Ohtsuka M, Kadono T, Kawaguchi M, Kukino R, Kono T, Sakai K, Takahara M, Tanioka M, Nakanishi T, Nakamura Y, Hashimoto A, Hasegawa M, Hayashi M, Fujiwara H, Maekawa T, Matsuo K, Madokoro N, Yamasaki O, Yoshino Y, Le Pavoux A, Tachibana T, Ihn H. The woud/ burn guidelines – 4: Guidelines for management of skin ulcers associated with connective tissue disease/ vasculitis. J Dermatol, 43: 729-757, 2016.
  147. Ito T, Kukino R, Takahara M, Tanioka M, Nakamura Y, Asano Y, Abe M, Ishii T, Isei T, Inoue Y, Imafuku S, Irisawa R, Ohtsuka M, Ohtsuka M, Ogawa F, Kadono T,
  148. Kawakami T, Kawaguchi M, Kono T, Kodera M, Sakai K, Nakanishi T, Hashimoto A, Hasegawa M, Hayashi M, Fujimoto M, Fujiwara H, Maekawa T, Matsuo K, Madokoro N, Yamasaki O, Yoshino Y, Le Pavoux A, Tachibana T, Ihn H. The woud/ burn guidelines – 5: Guidelines for management of lower leg ulcers/ varicose veins. J Dermatol, 43: 853-868, 2016.
  149. Yoshino Y, Ohtsuka M, Kawaguchi M, Sakai K, Hashimoto A, Hayashi M, Madokoro N, Asano Y, Abe M, Ishii T, Isei T, Ito T, Inoue Y, Imafuku S, Irisawa R, Ohtsuka M, Ogawa F, Kadono T, Kawakami T, Kukino R, Kono T, Kodera M, Takahara M, Tanioka M, Nakanishi T, Nakamura Y, Hasegawa M, Fujimoto M, Fujiwara H, Maekawa T, Matsuo K, Yamasaki O, Le Pavoux A, Tachibana T, Ihn H. The woud/ burn guidelines – 6: Guidelines for management of burns. J Dermatol, 43: 989-1010, 2016.
  150. Koga A, Kajihara I, Yamada S, Makino K, Ichihara A, Aoi J, Makino T, Fukushima S, Jinnin M, Ihn H.  Enhanced CCR9 expression levels in psoriatic skin are associated with poor clinical outcome to infliximab treatment. J Dermatol, 43: 522-525, 2016.
  151. Uchihara T, Imamura Y, Iwagami S, Kajihara I, Kanemaru H, Karashima R, Ida S, Ishimoto T, Baba Y, Sakamoto Y, Miyamoto Y, Yoshida N, Watanabe M, Iyama K, Ihn H, Baba H.  Small bowel perforation due to indistinguishable metasatsis of angiosarcoma: case report and brief literature review. Surg Case Rep 2: 42, 2016.
  152. Johno T, Egawa K, Jinnin M, Fukushima S, Masuguchi S, Inoue Y, Ihn H.  Clinical usefulness of immunostaining with CEA in distinction between malignant melanoma and Spitz nevus. Invest Dermatol Venereol Res 2: 1-4, 2016.
  153. Noguchi H, Hiruma M, Miyashita A, Makino K, Miyata K, Ihn H.  A case of fingernail onychomycosis due to Aspergillus flavus. Medical Mycol J, 57: E21-E25, 2016.
  154. Nakamura K, Jinnin M, Kudo H, Inoue K, Nakayama W, Honda N, Kajihara I, Masuguchi S, Fukushima S, Ihn H. The role of PSMB9 up-regulation by interferon signature in the pathophysiology of cutaneous lesions of dermatomyositis and lupus erythematosus. Br J Dermatol, 174: 1030-1041, 2016.
  155. Inoue M, Jinnin M, Wang Z, Nakamura K, Inoue K, Ichihara A, Moriya C, Sakai K, Fukushima S, Ihn H.  microRNA level is raised in the hair shafts of patients with dermatomyositis in comparison with normal subjects and patients wuth scleroderma. Int J Dermatol, 55: 786-790, 2016.
  156. Kimura T, Fukushima S, Miyashita A, Aoi J, Jinnin M, Kosaka T, Ando Y, Matsukawa M, Inoue H, Kiyotani K, Park J-H, Nakamura Y, Ihn H.  Myasthenic crisis and polymyositis induced by one dose of nivolumab. Cancer Sci, 107: 1055-1058, 2016.
  157. Yamada S, Jinnin M, Kajihara I, Nakashima T, Aoi J, Harada M, Igata T, Masuguchi S, Fukushima S, Ihn H. Cytokine expression profiles in the sera of cutaneous squamous cell carcinoma patients. Drug Discov Ther, 10: 172-176, 2016.
  158. Noguchi H, Hirum M, Maruo K, Jono M, Miyata K, Tanaka H, Tanabe K, Miyazaki Y, Ihn H.  Localized cutaneous cryptococcosis: Summary of reported cases in Japan. Med Mycol J 57: E35-E39, 2016.
  159. Nakamura K, Jinnin M, Harada M, Kudo H, Nakayama W, Inoue K, Ogata A, Kajihara I, Fukushima S, Ihn H.  Altered expression of CD63 and exomes in scleroderma dermal fibroblasts. J Dermatol Sci, 84: 30-39, 2016.
  160. Inoue H, Park JH, Kiyotani K, Zewde M, Miyashita A,Jinnin M, Kiniwa Y, Okuyama R, Tanaka R, Fujisawa Y, Kato H, Morita A, Asai J, Katoh N, Yokota K, Akiyama M, Ihn H, Fukushima S, Nakamura Y.  Intratumoral expression levels of PD-L1, GZMA, and HLA-A along with oligoclonal T cell expansion associate with response to nivolmab in metastatic melanomas. Oncoimmunology 5: e1204507, 2016.
  161. Tokuzumi A, Fukushima S, Miyashita A, Nakahara S, Kubo Y, Yamashita J, Harada M, Nakamura K, Kajihara I, Jinnin M, Ihn H.  Cell divison cycle-associated protein 1 as a new melanoma-associated antigen. J Dermatol, 43: 1399-1405, 2016.
  162. Wang Z, Nakamura K, Jinnin M, Kudo H, Goto M, Era T, Kira T, Nakashima T, Fukushima S, Ihn H.  Establishment and gene expression analysis of disease-derived induced pluripotent stem cells of scleroderma. J Dermatol Sci, 84: 186-196, 2016.
  163. Egashira S, Jinnin M, Harada M, Masuguchi S, Fukushima S, Ihn H.  Exome sequence analysis of Kaposiform hemangioendothelioma: identification of putative driver mutations. An Bras Dermatol, 91: 748-753, 2016
  164. Kadono T, Furuta K, Nagai Y, Kanoh H, Sekine Y, Noda Y, Mizokami H, Kataoka H, Nakagawa H, Tanaka K, Daian T, Kurashige Y, Nakagami G, Makabe N, Sekine R, Takahasaki M, Yoshino K, Endo T, Hidaka M, Maeshige N, Kubota K, Motita T, Okuwa M, Miyajima M, Noguchi M, Kinoshita S, Sobue M, Matsui Y, Murooka Y, Ishida Y, Sugama J, Tachibana T, Inoue Y, Ihn H.  JSPU Guidelines for the prevention and management of pressure ulcers (4 th Ed.). Jpn J PU 18: 455-554, 2016.
  165. Tanigawa H, Miyata K, Tian Z, Aoi J, Kadomatsu T, Fukushima S, Ogata A, Takeda N, Zhao J, Zhu S, Terada K, Endo M, Norinaga J, Sugizaki T, Sato M, Morioka MS, Manabe I, Mashimo Y, Hata A, Takemori Y, Yamamoto K, Murakami M, Araki K, Jinnin M, Ihn H, Oike Y.  Upregulation of ANGPTL6 in mouse keratinocytes enhances susceptibility to psoriasis. Sci Rep, 6: 34690, 2016.
  166. Nakahara S, Fukushima S, Yamashita J, Kubo Y, Tokuzumi A, Miyashita A, Harada M, Nakamura K, Jinnin M, Ihn H.  AT-rich interaction domain-containing protein 3B is a new tumor marker for melanoma. Acta Derm Venereol, 96: 112-114, 2017.
  167. Hamaguchi Y, Sumida T, Kawaguchi Y, Ihn H, Tanaka S, Asano Y, Motegi S, Kuwana M, Endo H, Takehara K.  Safety and tolerability of bosentan for digital ulcers in Japanese patients with systemic sclerosis: prospective, multicenter, open-labele study. J Dermatol, 44: 13-17, 2017.
  168. Nakayama W, Jinnin M, Tomizawa Y, Nakamura K, Kudo H, Inoue K, Makino K, Honda N, Kajihara I, Fukushima S, Ihn H.  Dysregulated Interleukin-23 signalling contributes to the increased collagen production in scleroderma fibroblasts via balancing microRNA expression. Rheumatology, 56: 145-155, 2017.
  169. Noguchi H, Hiruma M, Matsumoto T, Kano R, Ihn H.  Ungual hyalohyphomycosis caused by Fusarium proliferatum in an immunocompetent patient.  J Dermatol, 44: 88-90, 2017.
  170. Amagai M, Ikeda S, Hashimoto T, Mizuashi M, Fujisawa A, Ihn H, Matsuzaki Y, Ohtsuka M, Fujiwara H, Furuta J, Tago O, Yamagami J, Tanikawa A, Uhara H, Morita A, Nakanishi G, Tani M, Aoyama Y, Makino E, Muto M, Manabe M, Konno T, Murata S, Izaki S, Watanabe H, Yamaguchi Y, Matsukura S, Seishima M, Habe K, Yoshida Y, Kaneko S, Shindo H, Nakajima K, Kanekura T, Takahashi K, Kitajima Y, Hashimoto K.  A randomized double-blind trial of intranenous immunoglobulin for bullous pemphigoid. J Dermatol Sci, 85: 77-84, 2017.
  171. Harada M, Jinnin M, Wang Z, Hirano A, Tomizawa Y, Kira T, Igata T, Masuguchi S, Fukushima S, Ihn H.  The expression of miR-124 increases in aged skin to cause cell senecense and it decreases in squamous cell carcinoma. Biosci Trends, 10: 454-459, 2017.
  172. Wang Z, Jinnin M, Harada M, Kudo H, Inoue K, Nakayama W, Honda N, Makino K, Kajihara I, Fukushima S, Ihn H.  Diagnosis of nail psoriasis: evaluation of nail-derived microRNAs as potential novel biomarkers. Eur J Dermatol, 27: 20-27, 2017.
  173. Maeda S, Kajihara I, Ogata A, Johno T, Jinnin M, Ihn H.  Bromoderma in a pituitary adenoma patient treated with bromocriptine. J Dermatol, 44: e95-e96, 2017.
  174. Egashira S, Kajihara I, Kanemaru H, Uemura-Kiyohara M, Yamada-Kanazawa S, Nakahara S, Nagamoto E, Fukushima S, Jinnin M, Inoue Y, Ihn H.  Achieved good response of S-1 and docetaxel combination chemotherapy in two patients with metastatic extramammary Paget’s disease. J Dermatol, 44: e103-e104, 2017.
  175. Saeki H, Nakagawa H, Nakajo K, Ishii T, Morisaki Y, Aoki T, Cameron GS, Osuntokun OO, Akasaka T, Asano Y, Etoh T, Fujita Y, Hashimoto T, higashiyama M, Igarashi A, Ihn H, Iwatsuki K, Kabashima K, Kawada A, Kawashima M, Nakamura K, Okubo Y, Okuyama R, Ozawa A, Sayama K, Seishima M, Shiohara T, Takahara M, Takahashi H, Takehara K, Tanase K, Tani M, Umezawa Y, watanabe H, Yamanaka K.  Efficacy and safety of ixekizumab treatment for Japanese patients with moderate to severe plaque psoriasis, erythrodermic psoriasis and generalized pustular psoriasis: Results from a 52-week, open-label, phase 3 study (UNCOVER-J). J Dermatol, 44: 355-362, 2017.
  176. Noguchi H, Hiruma M, Matsumoto T, Yaguchi T, Sano A, Mitsui N, Watanabe S, Ihn H.  Subcutaneous cystic phaeohyphomycosis due to Pleurostomophora richardiae. J Dermatol, 44: e62-e63, 2017.
  177. Yamazaki N, Takenouchi N, Fujimoto M, Ihn H, Uchi H, Inozume T, Kiyohara Y, Uhara H, Nakagawa K, Furukawa H, Wada H, Noguchi K, Shimamoto T, Yokota K. Phase 1b study of pembrolizumab (MK-3475; anti-PD-1 monoclonal antibody) in Japanese patients with advanced melanoma (KEYNOTE-041). Cancer Chemother Pharmacol, 79: 651-660, 2017.
  178. Torii H, Nakano M, Yano T, Kadono K, Nakagawa H, Fujita Y, Horie K, Ito M, Iitani M, Ito K, Kaneko T, Akasaka T, Ohtsuki M, Yasuda M, Abe M, Tanida Y, Terui T, Arai S, Nakano T, Etoh T, Asano Y, Umezawa Y, Saeki H, Adachi M, Seishima M, Tokura Y, Morita A, Yamanaka K, Tani M, Tanimura H, Yamazaki F, Nishigori C, Kaneko S, Muto M, Nakamura M, Hino R, Nakayama J, Nakano T, Utani A, Sato T, Ihn H.  Efficacy and safety of dose escalation of infliximab therapy in Japanese patients with psoriasis: Results of the SPREAD study. J Dermatol, 44: 552-559, 2017.
  179. Terao C, Kawaguchi T, Dieude P, Varga J, Kuwana M, Hudson M, Kawaguchi Y, Matucci M, Ohmura K, Riemekasten G, Kawasaki A, Airo P, Horita T, Oka A, Hachulla E, Yoshifuji H, Japanese Scleroderma Genetic Consortium, Caramaschi P, Hunzelman N, Baron M, Hassouns P, Raychaudhuri S, Liao K, Gregersen P, Torii T, Tsuchiya N, Takehara K, Sato S, Ihn H, Riccieri V, Melchers I, Valentini G, Cauvet A, Martinez M, Mimori T, Matsuda F, Allanore Y. Trans-ethnic meta-analysis of genome-wide association study identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis. Ann Rheum Dis, 76: 1150-1158, 2017.
  180. Noguchi H, Hiruma M, Matsumoto T, Kano R, Tanaka M, Yaguchi T, Sonoda K, Ihn H.  Fungal melanonychia: Ungual phaeohyphomycosis caused by Botryospheria dothidea. Acta Derm Venereol,97: 765-766, 2017.
  181. Noguchi H, Hiruma M, Matsumoto T, Yaguchi T, Tashima H, Ihn H.  Multiple subcutaneous Candida abcesses on the palm and fingers in an immunocompetent patient. J Dermatol, 44: e174-e177.
  182. Sato Y, Kajihara I, Yamada-Kanazawa S, Jinnin M, Ihn H.  S100A7 expression levels in coordination with IL-8 indicate the clinical response to infliximab for psoriasis patients. J Dermatol, 44: 838-839, 2017.
  183. Noguchi H, Hiruma M, Matsumoto T, Kano R, Ihn H.  Ungual aspergillosis successfully treated with topical efinaconazole. J Dermatol, 44: 848-850, 2017.
  184. Yamazaki N, Kiyohara Y, Uhara H, Uehara J, Fujimoto M, Takenouhi T, Otsuka M, Uchi H, Ihn H, Minami H.  Efficacy and safety of nivolumab in Japanese patients with previously untreated advanced melanoma: a phase II study. Cancer Sci, 108: 1223-1230, 2017.
  185. Yamazaki N, Kiyohara Y, Uhara H, Iizuka H, Uehara J, Ohtsuka F, Fujisawa Y, Tekenouchi T, Isei T, Iwatsuki K, Uchi H, Ihn H, Minami H, Tahara H.  Cytokine biomarkers to predict antitumor responses to nivolumab suggested in a phase 2 study for advanced melanoma. Cancer Science, 1022-1031, 2017.
  186. Sawamura S, Kajihara I, Jinnin M, Honda Y, Ihn H.  Cutaneous spindle cell adenolipoma on the nose: A rare variant of lipoma. J Dermatol, 44: e156-e157, 2017.
  187. Sawamura S, Jinnin M, Shimbara M, Nakamura K, Kudo H, Inoue K, Nakayama W, Kajihara I, Fukushima S, Ihn H.  Serum levels of genomic DNA of 1(I) collagen are elevated in scleroderma patients. J Dermatol, 44: 927-931, 2017.
  188. Higashi-Kuwata N, Ogata-Aoki H, Hattori SI, Hayshi H, Danish M, Aoki M, Shiotsu C, Kuwamura T, Ihn H, Kobayashi H, Okada S, Mitsuya H.  Early phase dynamics of traceable mCherry fluorescent protein-carring HIV-1 infection in human peripheral blood mononuclear cells-transplanted NOD/SCID/Jak3-/- mice. Antiviral Res, 144: 83-92, 2017.
  189. Nakamura Y, Kajihara I, Yamada-Kanazawa S, Maeda-Otsuka S, Johno T, Aoi J, Igata T, Masuguchi S, Fukushima S, Jinnin M, Ihn H.  Intratumor dihydropyrimidine dehydrogenase mRNA expression levels are decreased in extramammary Paget’s disease. Drug Discov Ther, 11: 152-155, 2017.
  190. Umezaki N, Ishimoto T, Koba I, Nakaya T, Mawatari M, Kuramoto K, Izumi D, Sakamoto Y, Miyamoto Y, Yoshida N, Watanabe M, Inoue Y, Ihn H, Baba H.  Anorectal malignant melanoma with extensive intraepithelial extension: report of a case. Int Canc Conf J, in press
  191. Izumiya Y, Jinnin M, Kimura Y, Wang Z, Onoue Y, Hanatani S, Araki S, Ihn H, Ogawa H.  Expression of Let-7 family microRNAs in skin correlates negatively with severity of pulmonary hypertension in patients with systemic scleroderma. Int J Cardiol Heart Vasc. 8: 98-102, 2017.
  192. Yamada-Kanazawa S, Kajihara I, Fukushima S, Jinnin M, Masuzawa M, Makuzawa M, Amoh Y, Hoshina D, Abe R, Ihn H.  Inhibition of heat shock protein 90 exerts antitumor effect in angiosarcoma: involvement of the vascular endothelial growth factor signaling patway. Br J Dermatol, 177: 456-469, 2017 .
  193. Sawamura S, Kajihara I, Makino K, Makino T, Fukushima S, Jinnin M, Oyama B, Hashimoto T, Ihn H.  Systemic lupus erythematosus associated with myasthenia gravis, pemphigus foliaceus and chronic thyroiditis after thymectomy. Australas J Dermatol, 58: e120-e122, 2017.
  194. Oka A, Asano Y, Hasegawa M, Fujimoto M, Ishikawa O, Kuwana M, Kawaguchi Y, Yamamoto T, Takahashi H, Goto D, Endo H, Jinnin M, Mano S, Hosomichi K, Mabuchi T, Ueda MT, Nakagawa S, Beck S, Bahram S, Takehara K, Sato S, Ihn H.  RXRB is an MHC-encoded susceptibility gene associated with anti-topoisomerase I antibody-positive systemic sclerosis. J Invest Dermatol, 137: 1878-1886, 2017.
  195. Nakashima S, Jinnin M, Kanemaru H, Kajihara I, Igata T, Okamoto S, Tazaki Y, Harada M, Masuguchi S, Fukushima S, Masuzawa M, Amoh Y, Masuzawa M, Ihn H.  Down-regulation of miR-210, E2F3 and Ephrin A3 in angiosarcoma cell proliferation. Eur J Dermatol, in press.
  196. Ide M, Jinnin M, Tomizawa Y, Wang Z, Kajihara I, Fukushima S, Hashizume Yno Y, Asano Y, Ihn H.  Transforming growth factor  inhibitor Repsox down-regulates collagen expression of scleroderma dermal fibroblasts and prevents bleomycin-induced mice skin fibrosis. Exp Dermatol, in press.
  197. Ichihara A, Jinnin M, Ihn H.  Treatment of psoriasis with ustekinumab improved skin tightening in systemic sclerosis. Clin Exp Rheumatol, in press.
  198. Aoi J, Fukushima S, Jinnin M, Ihn H.  Fluorescence in situ hybridization for diagnosis of malignant melanoma using RREB1, MyB, Cep 6, and CCND1 probes in Japanese patients. Dermatologica Sinica, in press.
  199. Abe M, Nishigori C, Torii H, Ihn H, Ito K, Nagaoka M, Isogawa N, Kawaguchi I, Tomochika Y, Kobayashi M, Tallman AM, Papp KA.  Tofacitinib for the treatment of moderate to severe chronic plaque psoriasis in Japanese patients: Subgroup analyses from a randomized, placebo-controlled phase 3 trial. J Dermatol, in press.
  200. Kajihara I, Yamada-Kanazawa S, Maeda-Otsuka S, Jinnin M, Akaike K, Ihn H.  Secukinumab-induced interstitial pneumonia in a patient with psoriasis vulgaris. J Dermatol, in press.
  201. Inoue M, Miyashita A, Noguchi H, Hirose N, Nishimura K, Masuda M, Ihn H.  Human protothecosis in Japan: A belated case report with current status. J Dermatol, in press.
  202. Egashira S, Jinnin M, Ajino M, Shimozono N, Okamoto S, Tazaki Y, Hirano A, Ide M, Kijihara I, Aoi J, Harada M, Igata T, Masuguchi S, Fukushima S, Ihn H.  Chronic sun exposure-related fusion oncogenes EGFR-PPARGC1A in cutaneous squamous cell carcinoma. Sci Rep, in press.
  203. Ogata-Aoki H, Higashi-Kuwata N, Hattori SI, Hayshi H, Danish M, Aoki M, Shiotsu C, Hashiguchi Y, Hamada A, Kobayashi H, Ihn H, Okada S, Mitsuya H.  Raltegravir blocks the infectivity of red-fluorescent-protein (mCherry)-labeled HIV-1JR-FL in the setting of post-exposure prophylaxis in NOD/SCID/Jak3-/- mice transplanted with human PBMCs. Antiviral Res, in press.
  204. Noda-Yamashita T, Kajihara I, Kidou M, Ihn H.  Dyskeratosis congenital associated with congenital hypothyroidism. J Dermatol, in press.
     
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