Danias Ioannis, PhD
Professor and Co-Director

Department of Ophthalmology
SUNY Downstate Medical Center
USA, Phone: (718) 780-1530


Institution and Location



Field of Study

University of Athens Medical School, Athens Greece




University of Athens Medical School, Athens Greece



Histology & Embryology
/ Molecular Biology

Mount Sinai School of Medicine, NY




Lenox Hill Hospital, NY




Mount Sinai Medical Center, NY




Mount Sinai Medical Center, NY





He is  a clinician scientist with interest in glaucoma. His  laboratory has been working with various models of glaucoma for the past 18 years. This body of work encompasses the molecular events that lead to both IOP elevation as well as optic nerve and axonal neurodegeneration. They were the developers of the Tonolab tonometer and one of the first labs using the DBA/2 mouse model of glaucoma. They  were one of the first labs to point out the relationship between complement activation and glaucomatous neurodegeneration and more recently we identified the role of oral microbiome in the disease. In collaboration with Dr Candia we developed the bovine and later ovine models of steroid-induced IOP elevation. As a clinician scientist he see and treat patients with glaucoma as part of my regular clinical activities. This clinical exposure gives me a unique perspective in appreciating the real burden of this disease to the quality of life as well as the financial implications for the society.

Research Interest

  • Neuroprotection
  • Gene expression in glaucoma
  • Gene therapy in glaucoma
  • Neuroregeneration

Scientific Activities:

Positions and Honors


Assistant Professor, Department of Ophthalmology, Mount Sinai School of Medicine, NY


Associate Professor, Department of Ophthalmology, Mount Sinai School of Medicine, NY


Associate Professor, Department of Neuroscience, Mount Sinai School of Medicine, NY


Professor, Departments of Ophthalmology and Cell Biology, State University of New York Downstate, Brooklyn NY


Vice Chair for Research, Department of Ophthalmology, State University of New York,
Downstate, Brooklyn NY



Sybil S Harrington Scholar Award, RPB 2002-


Lewis Rudin Glaucoma prize


Regular Member of NIH DPVS study section


  1. Kontiola AI, Goldblum D, Mittag T and Danias J: Induction/Impact (Rebound) tonometry: A new     method for measuring IOP in the rat. Exp Eye Res 2001, 73:781-785.
  2. Danias J, Kontiola AI, Filippopoulos T, Mittag T: Method for the non-invasive measurement of intraocular pressure (IOP) in mice Invest Ophthalmol Vis Sci, 44:1138-41, 2003
  3. Morris CA, Crowston JG, Lindsey JD, Danias J, Weinreb RN. Comparison of invasive and non-invasive tonometry in the mouse. Exp Eye Res. 2006 82: 1094-9, Epub 2006 Feb 7
  4. Filippopoulos T, Matsubara A, Danias J, Huang W, Dobberfuhl A, Ren L, Mittag T, Miller JW and Grosskreutz CL. Predictability and limitations of non-invasive murine tonometry – comparison of two devices. Exp Eye Res, 2006 83: 194-201, Epub 2006] Mar 24
  5. Mittag TW, Danias J, Pohorenec G, Yuan H-M, Burakgazi E, Chalmers-Redman R, Podos SM and Tatton WG: Retinal damage after 3-4 months elevated intraocular pressure in a rat glaucoma model. Invest Ophthalmol Vis Sci 2000 Oct;41(11):3451-9.
  6. 2. Danias J, Shen F, Goldblum D, Chen B, Ramos-Esteban J, Podos SM, Mittag T: Cytoarchitecture of the retinal ganglion cells in the rat. Invest Ophthalmol Vis Sci, 43:587-94, 2002.
  7. 3. Danias J, Lee KC, Zamora MF, Chen B, Shen F, Filippopoulos T, Su Y, Goldblum D, Podos SM, Mittag T.: Quantitative analysis of retinal ganglion cell (RGC) loss in aging DBA/2NNia glaucomatous mice: comparison with RGC loss in aging C57/BL6 mice. Invest Ophthalmol Vis Sci., 44(12):5151-62, 2003.
  8. 4. Danias J, Shen F, Kavalarakis M, Chen B, Goldblum D, Lee K, Zamora MF, Su Y, Podos SM, Mittag T.Characterization of retinal damage in the episcleral vein cauterization rat glaucoma model. Exp Eye Res. Exp Eye Res. 2006 82: 219-28. Epub 2005 Aug 16. Erratum in: Exp Eye Res. 2006 83: 1002.Brodie, Scott E [added]
  9. Stasi K, Nagel D, Yang X, Wang RF, Ren L, Podos S.M, Mittag T, Danias J. Complement Component 1Q (C1Q) upregulation in retina of murine, primate and human glaucomatous eyes. Invest Ophthalmol Vis Sci., 2006 47(3):1024-9
  10. 2. Panagis L, Zhao X, Ge Y, Ren L, Mittag TW, Danias J. Retinal gene expression changes related to IOP exposure and axonal loss in DBA/2J mice. Invest Ophthalmol Vis Sci. 2011 Oct 3; 52(11):7807-16. Print 2011
  11. 3. Astafurov K, Elhawy E, Ren L, Dong CQ, Igboin C, Hyman L, Griffen A, Mittag T, Danias J. Oral microbiome link to neurodegeneration in glaucoma. PLoS One. 2014 Sep 2; 9(9):e104416. doi:10.1371/journal.pone. 0104416. eCollection 2014.
  12.  Pasquale LR, Hyman L, Wiggs JL, Rosner BA, Joshipura K, McEvoy M, McPherson ZE, Danias J, Kang JH. Prospective Study of Oral Health and Risk of Primary Open-Angle Glaucoma in Men: Data from the Health Professionals Follow-up Study. Ophthalmology. 2016 Nov; 123(11):2318-2327.
  13. Gerometta R, Podos SM, Candia OA, Wu B, Mittag T, Danias J.: Steroid-induced ocular hypertension in normal cattle. Arch Ophthalmol 122(10):1492-7, 2004
  14. 2. Gerometta R, Podos SM, Danias J, Candia OA. Steroid-induced ocular hypertension in normal sheep.Invest Ophthalmol Vis Sci. 2009 Feb; 50(2):669-73. Epub 2008 Sep 29.
  15.  Danias J, Gerometta R, Ge Y, Ren L, Panagis L, Mittag TW, Candia OA, Podos SM. Gene expression changes in steroid-induced IOP elevation in bovine trabecular meshwork. Invest Ophthalmol Vis Sci. 2011 Nov 7;52(12):8636-45. Print 2011 Nov
  16. Kumar S, Shah S, Tang HM, Smith M, Borrás T, Danias J. Tissue plasminogen activator in trabecular meshwork attenuates steroid induced outflow resistance in mice. PLoS One. 2013 Aug 19;8(8):e72447.PMID: 23977299
  17. Lim H, Danias J. Effect of axonal micro-tubules on the morphology of retinal nerve fibers studied by second-harmonic generation. J Biomed Opt. 2012 Nov 1; 17(11):110502. doi:10.1117/1.JBO.17.11.110502. PMID:23089666
  18. 2. Lim H, Danias J. Label-free morphometry of retinal nerve fiber bundles by second-harmonic-generation microscopy. Opt Lett. 2012 Jun 15; 37(12):2316-8. doi: 10.1364/OL.37.002316. PMID:22739893
  19.  Torrejon KY, Pu D, Bergkvist M, Danias J, Sharfstein ST, Xie Y. Recreating a human trabecular meshwork outflow system on microfabricated porous structures. Biotechnol Bioeng. 2013 Dec;110(12):3205-18
  20. Torrejon KY, Papke EL, Halman JR, Stolwijk J, Dautriche CN, Bergkvist M, Danias J, Sharfstein ST, Xie Y. Bioengineered glaucomatous 3D human trabecular meshwork as an in vitro disease model. Biotechnol Bioeng. 2016 Jun; 113(6):1357-68.

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