Professor of Pathology & Laboratory Medicine
University of Cincinnati College of Medicine
USA
Education
1998 – 2001 | Post-doctoral Fellow, Department of Pathology & Laboratory Medicine, University of Cincinnati - College of Medicine, Cincinnati, OH |
1996 – 1998 | Post-doctoral Assistant, Department of Pharmacology & Therapeutics, Louisiana State University - College of Medicine, Shreveport, LA |
1992 – 1994 | Ph.D., in molecular neuron-pharmacology, Peking Union Medical College & Chinese Academy of Medical Sciences (PUMC & CAMS), China |
1985 – 1988 | M.S., in cardiovascular pharmacology, Jiangxi Medical College, China |
1977 – 1981 | B.A., in pharmacy, Jiangxi College of Traditional Chinese Medicine, China |
Profile
Research Interest
Dr. Liu's laboratory is currently studying the role of hypothalamic apolipoprotein AIV (apo AIV) in the development of obesity and how it can be modulated for preventive and therapeutic purposes.
Apo AIV is a circulating signal released from intestinal cells in response to lipid feeding, and it contributes to the anorectic effect of a lipid meal.
We have demonstrated that apo AIV is also synthesized in the hypothalamus, and that hypothalamic apo AIV gene and protein expression is regulated physiologically.Professional Activities:
Academic appointments:
2013 – present. | Professor (tenured) | Department Pathology & Laboratory Medicine, University of Cincinnati - College of Medicine, Cincinnati, OH |
2007 – 2013 | Associate Professor (tenured) | Department Pathology & Laboratory Medicine, University of Cincinnati - College of Medicine, Cincinnati, OH |
2002–2007 | Assistant Professor | Department Pathology & Laboratory Medicine, University of Cincinnati - College of Medicine, Cincinnati, OH |
2001 – 2002 | Research Instructor | Department of Pathology & Laboratory Medicine, University of Cincinnati - College of Medicine, Cincinnati, OH |
1994 – 1996 | Associate Professor | Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China |
1988 – 1992 | Assistant Professor | Jiangxi Medical College, Nanchang, China |
1981 – 1985 | Instructor | Jiangxi College of Traditional Chinese Medicine, China |
Memberships in professional organizations:
2004 – present |
The Society for the Study of Ingestive Behavior (SSIB, USA) |
2000 – present |
North American Association for the Study of Obesity (NAASO, USA) |
1998 – present |
Society for Neuroscience (SFN, USA) |
Honors and Awards
Publications
- Yang S, Liu M, Wu T. Magnitude of the Difference between Fasting and Non-fasting Triglycerides, and Its Dependent Factors. Journal of Community Medicine & Health Education. (In press)
- Shen L, Wang DQ, Lo CC, Arnold M, Tso P, Woods SC, Liu M. Gut vagal afferents are necessary for the eating-suppressive effect of intraperitoneally administered ginsenoside Rb1 in rats.Physiol Behav. 2015 Sep 15;152(Pt A):62-67
- Shen L, Haas M, Wang DQ, May A, Lo CC, Obici S, Tso P, Woods SC, Liu M. Ginsenoside Rb1 increases insulin sensitivity by activating AMP-activated protein kinase in male rats.Physiol Rep. 2015 Sep; 3(9).
- De Bari,O, Wang,H; Portincasa,P, Liu,M, Wang,D.Q.H. The deletion of the estrogen receptor alpha gene reduces susceptibility to estrogen-induced cholesterol cholelithiasis in female mice. Biochim Biophys Acta. 2015 Oct;1852(10 Pt A):2161-9
- De Bari,O, Tony,Y, Wang,TY, Liu,M, Portincasa,P, Wang,D.Q.H. Estrogen induces two distinct cholesterol crystallization pathways by activating ERα and GPR30 in female mice. Journal of Lipid Research. 2015 Sep;56(9):1691-700
- Wang,F, Kohana,AB, Lo,CM, Liu,M, Howles,P, Tso,P. Apolipoprotein A-IV: a protein intimately involved in metabolism. Journal of Lipid Research. 2015 Aug;56(8):1403-18.
- Begg,DP, May,M, Mul,JD, Liu,M. D’Alessio,DA, Seeley,RJ, and Woods,SC. Insulin detemir is transported from blood to cerebrospinal fluid and has prolonged central anorectic action relative to NPH insulin. Diabetes. 2015 Jul;64(7):2457-66.
- Li,XM, Xu,M, Liu,M, Ji,Y and Li,Zf. TNF-alpha and IL-6 inhibit apolipoprotein A-IV production induced by linoleic acid in human intestinal Caco2 cells. Journal of Inflammation(Lond). 2015 Mar 22;12:22.
- Kohan,AB, Wang,F, Lo,CM, Liu,M, and Tso,P. ApoA-IV: Current and emerging roles in intestinal lipid metabolism, glucose homeostasis, and satiety. Am J Physiol Gastrointest Liver Physiol. 2015; Mar 15; 308:G472-81
- Shen,L, Liu,Y, Wang,DQH, Tso,P, Woods,SC, Liu,M.Estradiol stimulates apolipoprotein A-IV gene expression in the nucleus of the solitary tract through estrogen receptor-a. Endocrinology.2014;155:3882-90
- De Bari,O, Wang,H,H, Portincasa,P, Paik,C,N, Liu,M, Wang,DQH.Ezetimibe prevents the formation of estrogen-induced cholesterol gallstones in ERα(+/+)/GPR30(+/+) mice. European Journal of Clinical Investigation.2014; 44: 1159–1168.
- De Bari, O, Wang, TY, Liu,M, Paik, CN, Portincasa, P, Wang DQH.Cholesterol Cholelithiasis in Pregnant Women: Pathogenesis, Prevention and Treatment. Annals of Hepatology. 2014; 13:728-45
- Wang,TY, Liu,M, Portincasa,P, Wang,DQH. New insights into the molecular mechanism of intestinal fatty acid absorption. European Journal of Clinical Investigation. 2013; 43:1203-23.
- Shen,L, Xiong,Y, Wang,DQH, Howles,H, Basford,JE, Wang,J, Xiong,YQ, Hui,DY, Woods,SC, and Liu,M. Ginsenoside Rb1 reduces fatty liver by activating AMP-activated protein kinase in obese rats. Journal of Lipid Research2013; 54:1430-8.
- Begg,DP, Mul,JD, Liu,M, Reedy,B, D’Alessio,DA, Seeley,RJ, Woods,SC.Reversal of diet-induced obesity increases insulin transport into CSF and restores sensitivity to the anorexic action of central insulin. Endocrinology. 2013; 154:1047-54
- Liu,M, Kuhel,DG, Shen,L, Hui,DY, Woods,WC: Apolipoprotein E does not cross the blood-cerebrospinal fluid (CSF) barrier, as revealed by an improved technique for sampling CSF from mice.Am J Physiol Regul Integr Comp Physiol. 2012;303:R903-8
- Lo,CM, Langhans,W, Georgievsky,M, Arnold,M, Caldwell,JL, Cheng,S, Liu,M, Woods,SC, Tso,P. Apolipoprotein AIV requires cholecystokinin and vagal nerves to suppress food intake. Endocrinology. 2012;153:5857-65
- Liu,M,Shen,L, Begg,DP, D'alessio,DA, Woods,SC:Insulin increases central apolipoprotein E levels as revealed by an improved technique for collection of cerebrospinal fluid from rats. J Neurosci Methods. 209:106– 112, 2012
- Shen,L, Hillebrand,A, Wang,DQH,Liu,M: Isolation and primary culture of rat hepatic cells. J Vis ExpJun 29; (64), 2012
- Yoshimichi,G, Lo,CM, Tamashiro,KL, Ma,LY, Lee,DM, Begg,DP, Liu,M, Sakai,RR, Woods,SC,Yoshimatsu,H, Tso,P:Effect of peripheral administration of cholecystokinin on food intake in apolipoprotein AIV knockout mice.Am J Physiol Gastrointest Liver Physiol302:G1336–G1342, 2012.
- de,BO, Neuschwander-Tetri,BA, Liu,M, Portincasa,P, Wang,DQ: Ezetimibe: its novel effects on the prevention and the treatment of cholesterol gallstones and nonalcoholic Fatty liver disease. J Lipids 2012:302847, 2012
- Shen,L, Wang,DQ, Tso,P, Jandacek,RJ, Woods,SC, Liu,M: Apolipoprotein E reduces food intake via PI3K/Akt signaling pathway in the hypothalamus. Physiol Behav 105:124-128, 2011
- Lo,CM, Obici,S, Dong,HH, Haas,M, Lou,D, Kim,DH, Liu,M, D'Alessio,D, Woods,SC, Tso,P: Impaired insulin secretion and enhanced insulin sensitivity in cholecystokinin-deficient mice. Diabetes 60:2000-2007, 2011
- Xiong,Y, Shen,L, Liu,KJ, Tso,P, Xiong,Y, Wang,G, Woods,SC, Liu,M: Antiobesity and antihyperglycemic effects of ginsenoside Rb1 in rats. Diabetes 59:2505-2512, 2010
- Shen,L, Wang,DQ, Lo,CM, Tso,P, Davidson,WS, Woods,SC, Liu,M: Estradiol increases the anorectic effect of central apolipoprotein A-IV. Endocrinology 151:3163-3168, 2010
- Shen,L, Tso,P, Wang,DQ, Woods,SC, Davidson,WS, Sakai,R, Liu,M: Up-regulation of apolipoprotein E by leptin in the hypothalamus of mice and rats. Physiol Behav 98:223-228, 2009
- Wang,HH, Portincasa,P, Liu,M, Tso,P, Samuelson,LC, Wang,DQ: Effect of gallbladder hypomotility on cholesterol crystallization and growth in CCK-deficient mice. Biochim Biophys Acta 1801:138-146, 2010
- Wang,HH, Liu,M, Clegg,DJ, Portincasa,P, Wang,DQ: New insights into the molecular mechanisms underlying effects of estrogen on cholesterol gallstone formation. Biochim Biophys Acta 1791:1037-1047, 2009
- Shen,L, Carey,K, Wang,DQ, Woods,SC, Liu,M: Food-entrained rhythmic expression of apolipoprotein E expression in the hypothalamus of rats. Brain Res 1273:66-71, 2009
- Lo,CM, Xu,M, Yang,Q, Zheng,S, Carey,KM, Tubb,MR, Davidson,WS, Liu,M, Woods,SC, Tso,P: Effect of intraperitoneal and intravenous administration of cholecystokinin-8 and apolipoprotein AIV on intestinal lymphatic CCK-8 and apo AIV concentration. Am J Physiol Regul Integr Comp Physiol 296:R43-R50, 2009
- Shen,L, Tso,P, Woods,SC, Clegg,DJ, Barber,KL, Carey,K, Liu,M: Brain apolipoprotein E: an important regulator of food intake in rats. Diabetes 57:2092-2098, 2008
- Shen,L, Pearson,KJ, Xiong,Y, Lo,CM, Tso,P, Woods,SC, Davidson,WS, Liu,M: Characterization of apolipoprotein A-IV in brain areas involved in energy homeostasis. Physiol Behav 95:161-167, 2008
- Tubb,MR, Silva,RA, Pearson,KJ, Tso,P, Liu,M, Davidson,WS: Modulation of apolipoprotein A-IV lipid binding by an interaction between the N and C termini. J Biol Chem 282:28385-28394, 2007
- Lo,CM, Zhang,DM, Pearson,K, Ma,L, Sun,W, Sakai,RR, Davidson,WS, Liu,M, Raybould,HE, Woods,SC, Tso,P: Interaction of apolipoprotein AIV with cholecystokinin on the control of food intake. Am J Physiol Regul Integr Comp Physiol 293:R1490-R1494, 2007
- Shen,L, Tso,P, Woods,SC, Sakai,RR, Davidson,WS, Liu,M: Hypothalamic Apolipoprotein A-IV Is Regulated by Leptin. Endocrinology 148:2681-2689, 2007
- Lo,CM, Ma,L, Zhang,DM, Lee,R, Qin,A, Liu,M, Woods,SC, Sakai,RR, Raybould,HE, Tso,P: Mechanism of the induction of brain c-Fos-positive neurons by lipid absorption. Am J Physiol Regul Integr Comp Physiol 292:R268-R273, 2007
- Gotoh,K, Liu,M, Benoit,SC, Clegg,DJ, Davidson,WS, D'Alessio,D, Seeley,RJ, Tso,P, Woods,SC: Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake. Am J Physiol Regul Integr Comp Physiol 290:R202-R207, 2006
- Pearson,K, Liu,M, Shen,L, Tso,P, Davidson,WS: Bacterial expression and characterization of rat apolipoprotein E. Protein Expr Purif 41:447-453, 2005
- Qin,X, Shen,H, Liu,M, Yang,Q, Zheng,S, Sabo,M, D'Alessio,DA, Tso,P: GLP-1 reduces intestinal lymph flow, triglyceride absorption, and apolipoprotein production in rats. Am J Physiol Gastrointest Liver Physiol 288:G943-G949, 2005
- Jandacek,RJ, Anderson,N, Liu,M, Zheng,S, Yang,Q, Tso,P: Effects of yo-yo diet, caloric restriction, and olestra on tissue distribution of hexachlorobenzene. Am J Physiol Gastrointest Liver Physiol 288:G292-G299, 2005
- Shen,L, Ma,LY, Qin,XF, Jandacek,R, Sakai,R, Liu,M: Diurnal changes in intestinal apolipoprotein A-IV and its relation to food intake and corticosterone in rats. Am J Physiol Gastrointest Liver Physiol 288:G48-G53, 2005
- Woods,SC, D'Alessio,DA, Tso,P, Rushing,PA, Clegg,DJ, Benoit,SC, Gotoh,K, Liu,M, Seeley,RJ: Consumption of a high-fat diet alters the homeostatic regulation of energy balance. Physiol Behav 83:573-578, 2004
- Tso,P, Liu,M: Ingested fat and satiety. Physiol Behav 81:275-287, 2004
- Liu,M, Shen,L, Liu,Y, Tajima,D, Sakai,R, Woods,SC, Tso,P: Diurnal Rhythm of Apolipoprotein A-IV in Rat Hypothalamus and Its Relation to Food Intake and Corticosterone. Endocrinology 145:3232-3238, 2004
- Tso,P, Liu,M: Apolipoprotein A-IV, food intake, and obesity. Physiol Behav 83:631-643, 2004
- Liu,M, Shen,L, Liu,Y, Woods,SC, Seeley,RJ, D'Alessio,D, Tso,P: Obesity induced by a high-fat diet downregulates apolipoprotein A-IV gene expression in rat hypothalamus. Am J Physiol Endocrinol Metab 287:E366-E370, 2004
- Tso,P, Sun,W, Liu,M: Gastrointestinal satiety signals IV. Apolipoprotein A-IV. Am J Physiol Gastrointest Liver Physiol 286:G885-G890, 2004
- Liu,M, Doi,T, Tso,P: Regulation of intestinal and hypothalamic apolipoprotein A-IV. Exp Biol Med (Maywood ) 228:1181-1189, 2003
- Liu,M, Maiorano,N, Shen,L, Pearson,K, Tajima,D, Zhang,DM, Woods,SC, Seeley,RJ, Davidson,WS, Tso,P: Expression of biologically active rat apolipoprotein AIV in Escherichia coli. Physiol Behav 78:149-155, 2003
- Liu,M, Shen,L, Doi,T, Woods,SC, Seeley,RJ, Tso,P: Neuropeptide Y and lipid increase apolipoprotein AIV gene expression in rat hypothalamus. Brain Res 971:232-238, 2003
- Tso,P, Liu,M, John,KT, Thomson,AB: The role of apolipoprotein A-IV in the regulation of food intake. Annu Rev Nutr 21:231-254, 2001
- Liu,M, Doi,T, Shen,L, Woods,SC, Seeley,RJ, Zheng,S, Jackman,A, Tso,P: Intestinal satiety protein apolipoprotein AIV is synthesized and regulated in rat hypothalamus. Am J Physiol Regul Integr Comp Physiol 280:R1382-R1387, 2001
- Liu,M, Tso,P: The effect of fasting and re-feeding on apolipoprotein A-IV, A-I and C-III gene expression in both intestine and brain. Digestion 63:263, 2001
- Doi,T, Liu,M, Seeley,RJ, Woods,SC, Tso,P: Effect of leptin on intestinal apolipoprotein AIV in response to lipid feeding. Am J Physiol Regul Integr Comp Physiol 281:R753-R759, 2001
- Liu,M, Glowa,JR: Regulation of benzodiazepine receptor binding and GABA(A) subunit mRNA expression by punishment and acute alprazolam administration. Brain Res 887:23-33, 2000
- Liu,M, Glowa,JR: Alterations of GABAA receptor subunit mRNA levels associated with increases in punished responding induced by acute alprazolam administration: an in situ hybridization study. Brain Res 822:8-16, 1999
- Tso,P, Liu,M, Kalogeris,TJ: The role of apolipoprotein A-IV in food intake regulation. J Nutr 129:1503-1506, 1999
- Liu,M, Shen,L, Tso,P: The role of enterostatin and apolipoprotein AIV on the control of food intake. Neuropeptides 33:425-433, 1999
- Shen,L, Zhang,JT, Liu,M: The progress in the research of action of ginseng's immunoregulation. Chinese Traditional and Herbal Drugs 8:499-502, 1997
- Liu,M, Zhang,JT: Effects of ginsenoside Rg1 on c-fos gene expression and cAMP levels in rat hippocampus. Zhongguo Yao Li Xue Bao 17:171-174, 1996
- Liu,M, Zhang,JT: Ameliorating age-related alterations of ginsenoside Rg1 in open-field behavioral activity and moter responses in old rats. Chin Pharm J 31:464-467, 1996
- Liu,M: [Studies on the anti-aging and nootropic effects of ginsenoside Rg1 and its mechanisms of actions]. Sheng Li Ke Xue Jin Zhan 27:139-142, 1996
- Liu,M, Zhang,JT: [Studies on the mechanisms of immunoregulatory effects of ginsenoside Rg1 in aged rats]. Yao Xue Xue Bao 31:95-100, 1996
- Liu,M, Zhang,JT: [Immunoregulatory effects of ginsenoside Rg1 in aged rats]. Yao Xue Xue Bao 30:818-823, 1995
- Liu,M, Zhang,J: Effects of ginsenoside Rb1 and Rg1 on synaptosomal free calcium level, ATPase and calmodulin in rat hippocampus. Chin Med J (Engl ) 108:544-547, 1995
- Liu,M, Zhang,JT: [Protective effects of ginsenoside Rb1 and Rg1 on cultured hippocampal neurons]. Yao Xue Xue Bao 30:674-678, 1995
- Liu,M, Zhang,JT: Learning and memory with c-fos oncogene. Chinese Pharmacological Bulletin 11:1-5, 1995
- Liu,M, Hong,GH, Cai,XL: Effects of Corydalins Amabilis Migo total alkaloids on platelet cAMP and cGMP. Nuclear Techniques 13:61-62, 1990
- Liu,M, Hong,GH: Effects of Corydalins Amabilis Migo total alkaloids on physiologic properties of isolated guinea pig myocardium. Chinese Pharmacology Bulletin 5:104-106, 1989
- Liu,M, Hong,GH: Study of antagonistic effect of Corydalins Amabilis Migo total alkaloids on calcium. Acta Academia Medicine Jiangxi 29:1-4, 1989
- Liu,M, Hong,GH: Effects of Cymbopogon Goering 11 (Steud.) A. Camus volatile oil on physiologic properties of isolated guinea pig myocardium. China Journal of Chinese Materia Medica 14:44-46, 1989
- Liu,M, Hong,GH: Effect of Corydalins Amabilis Migo total alkaloids on function of platelets in rats. Chinese Pharmacology Bulletin 4:301-304, 1988