Education

Biography

Dr. Poon is currently the CSO of Hisun Pharma – Biopharm. He previously worked for SAFC, Roskamp Institute in USA. He completed his Ph.D. in Biological Chemistry at University of Kentucky, and MBA from University of South Florida. He has years of experience in the field of biological theraputics, analytical research, bioinformatics and proteomics. He has more than 10 years of cell culture experience with focus on biopharmaceutical products.

He published more than 30 peer-reviewed articles, and contributes to more than 5 book chapters. He is currently the managing editor for biomedical and pharmacology journal  ; associate Editor for Journal of Chemistry, Biochemistry; and Molecular Biology, Band Journal of Bioinformatics and Biometrics.

Research Interest

• Biotherapeutics
• Proteomics
• Metabolic
• Cell line engineering
• Cell cultures
• Multivariate analysis
• QbD, PAT

Scientific Activities

Employment History

Professional Activities

• Member, Young Investigator Awards (YIA) committee, The Society for Free Radical Biology and Medicine 13th Annual Meeting (2006)
• Judges, The Society for Free Radical Biology and Medicine 13th Annual Meeting Abstract (2006)
• Reviewer, Neuroscience letters (2005 - 2008)
• Reviewer, Brain research, (2005 - 2008)
• Reviewer, Scientific Journal International, (2007 - Present)
• Member, Editorial Review Board, Scientific Journal International, (2007-Present)
• Reviewer, Journal of Free Radicals in Biology and Medicine, (2006 – Present)
• Consultant, Reuter Insight Expert, (2007- Present)
• Technical Advisor, Biocompare.com, (2007- Present)
• Associate Editor, Journal of Chemistry, Biochemistry and Molecular Biology (2009-Present)
• Associate Editor-in-Chief  International Journal of Biometrics and Bioinformatics (2009-Present)
• Member of Science Advisory Board (2007-Present)
• Member of Bioinformatics Organization (2006-Present)
• Member of Golden Key National Honor Society (2001-Present)
• Member of Society for Neuroscience (2002-2007)
• Member of Free Radical in Biology and Medicine (2005-2007)

Honors And Awards

• Zhejiang Province 1000 Talent Program Expert (浙江省千人计划)
• Hangzhou  Innovative Lab Leader  (杭州创新实验室领军人物）
• Fuyang City 5110 Expert Award (富阳市5110引进人才)
• Sophomore Scholarship (Northeast Oklahoma A&M College)
• NEO A&M College Development Foundation Scholarship
• President’s Honor Roll of Northeastern Oklahoma A&M College (two semesters)
• Dean’s List ( five semesters) (University of Kentucky)
• Franklin Tuttle Fellowship (University of Kentucky)
• Kentucky Graduate Scholarship (University of Kentucky)
• Research Challenge Trust Fund Fellowship (University of Kentucky)
• Graduate School Academic Non-service Fellowship (University of Kentucky)
• Air Force ROTC Scientific Research Fellowship (University of Kentucky)

Publications

1. Susan A. Farr, H. Fai Poon, Dilek Dogrukol-Ak, Jennifer Drake, William A. Banks, Edward Eyerman, D. Allan Butterfield and John E. Morley, (2003) The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice. Journal of Neurochemistry. 84:1173-83.
2. H. Fai Poon, Alessandra Castegna, Susan A Farr, Visith Thongboonkerd, Bert C. Lynn, William A. Banks, John E. Morley, Jon B. Klein and D. Allan Butterfield, (2004) Quantitative proteomics analysis of specific proteins expression and oxidative modification in aged SAMP8 mice brain. Neuroscience. 126:915-26.
3. H. Fai Poon, Gururaj Joshi, Rukhsana Sultana, Susan A Farr, William A. Banks, John E. Morley, Vittorio Calabrese and D. Allan Butterfield, (2004)Antisense directed at the Ab region of APP decreases brain oxidative markers in aged senescence accelerated mice. Brain Research. 1018:86-96.
4. H. Fai Poon, Susan A Farr, Visith Thongboonkerd, Bert C. Lynn, William A. Banks, John E. Morley, Jon B. Klein and D. Allan Butterfield, (2005)Proteomic analysis of specific proteins in aged SAMP8 mice treated with alpha-lipoic acid: implications for aging and age-related neurodegenerative disorders, Neurochemistry International. 46:159-168.
5. H. Fai Poon, Mark Frasier, Ben Wolozin and D. Allan Butterfield, (2005) Mitochondrial associated metabolic proteins are selectively oxidized in A30P a-synuclein transgenic mice – a model of familial Parkinson’s disease. Neurobiology of Disease. 18:492-498.
6. H. Fai Poon, Susan A Farr, William A. Banks, John E. Morley, William Pierce, Jon Klein and D. Allan Butterfield, (2005)Proteomics identification of less oxidized brain protein in aged senescence accelerated micetreated with antisense directed at the Ab region of APP. Molecular Brain Research. 138:8-16
7. H. Fai Poon, Radhika A. Vaishnav,Thomas V. Getchell, Marilyn L. Getchell and D. Allan Butterfield, (2005) Proteomic identification of differentially expressed proteins in the aging murine olfactory system and transcriptional analysis of the associated genes. Journal of Neurochemistry. 94:280-92
8. H. Fai Poon, Kenneth Hensley, Visith Thongboonkerd, Bert C. Lynn, William A. Banks, John E. Morley, Jon B. Klein and D. Allan Butterfield, (2005) Redox proteomics analysis of oxidatively modified proteins in G93A-SOD1 transgenic mice – A model of familial amyotrophic lateral sclerosis. Free Radical Biology & Medicine. 39:453-62
9. Chava B Pocernich, Debra Boyd-Kimball, H. Fai Poon, Visith Thongboonkerd, Bert C. Lynn, Jon B Klein, Vittorio Calebrese, Avindra Nath and D Allan Butterfield, (2005) Proteomics analysis of human astrocytes expressing the HIV protein Tat.Molecular Brain Research. 133:307-316.
10. Chava B Pocernich, C.B., H. Fai Poon, Debra Boyd-Kimball, Bert C. Lynn, Avindra Nath, Jon B Klein and D Allan Butterfield, (2005) Proteomic analysis of oxidatively modified proteins induced by the mitochondrial toxin 3-nitroproprionic acid in human astrocytes expressing the HIV protein Tat.Molecular Brain Research. 133:299-206.
11. Marzia Perluigi, H. Fai Poon, Kenneth Hensley, William M. Pierce, Jon B. Klein, Vittorio Calabrese, Carlo De Marco and D. Allan Butterfield, (2005) Proteomic analysis of HNE-modified proteins in G93A-SOD1 transgenic mice - a model of familial amyotrophic lateral sclerosis, Free Radicals Biology & Medicine. 38: 960-968.
12. Debra Boyd-Kimball, Rukhsana Sultana, H. Fai Poon, Halfiz Abdul-Mohammad, Bert C. Lynn, Jon B. Klein and D. Allan Butterfield, (2005) g-Glutamyl cysteine ethyl ester protection of proteins from Ab(1-42)-mediated oxidative stress in neuronal cell culture: a proteomics approach.J Neuroscience Research. 79:707-713.
13. Debra Boyd-Kimball, Alessandra Castegna, Robin Petroze, H. Fai Poon, Rukhsana Sultana, Bert C. Lynn, Jon B. Klein and D. Allan Butterfield, (2005) Proteomic identification of protein oxidized by Ab(1-42) in synaptosomes: Implications of Alzhiemer’s disease. Brain Research. 1044:15-26.
14. Debra Boyd-Kimball, H. Fai Poon,Giancarlo Pepeu and Fiorella Casamenti and D. Allan Butterfield, (2005)Proteomic identification of proteins specifically oxidized by intracerebral injection of A(1-42) into rat brain. Neuroscience. 232:313-324.
15. Marzia Perluigi, H. Fai Poon, William Maragos, William M. Pierce, Jon B. Klein, Vittorio Calabrese, Carlo De Marco and D. Allan Butterfield, (2005) Proteomic analysis of protein expression and oxidative modification in R6/2 transgenic mice – a model of Huntington’s disease. Molecular Cell Proteomics. 4:1849-1861.
16. Allan Butterfield, H. Fai Poon, , Daret St. Clair, and Jeffery N. Keller William M Pierce , Jon B Klein and William R Markesbery (2006) Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: Insights into the development of Alzheimer's disease. Neurobiology of Disease. 22:223-232.
17. Ruksana Sultana, H. Fai Poon, Jian Cai, William M. Pierce, Michael Merchant, Jon B Klein, William R Markesbery, D. Allan Butterfield, (2006)  Identification of nitrated proteins in Alzheimer's disease brain using a redox proteomics approach. Neurobiology of Disease. 22:76-87.
18. H. Fai Poon, Vittorio Calabrese, Menotti Calvani and D. Allan Butterfield, (2006)Redox proteomics analysis of specific protein oxidation in aged rat brain and its modulation by L-acetylcarnitine:  insights into the mechanisms of action of this proposed therapeutic agent for CNS disorders associated with oxidative stress.Antioxidant and Redox Signaling. 8:381-394.
19. H. Fai Poon, Holly Shepherd, Tanea Reed, Vittorio Calabrese, Jain Cai, William Pierce, Jon Klein and D. Allan Butterfield, (2006)Proteomics analysis provide insight into caloric restriction mediated oxidation and expression of brain proteins associated with age-related impaired cellular processes: mitochondrial dysfunction, glutamate dysregulation and impaired protein synthesis.Neurobiology of Aging. 27:1020-1034.
20. H. Fai Poon, Radhika A. Vaishnav, Thomas V. Getchell, Marilyn L. Getchell and D. Alan Butterfield, (2006) Quantitative proteomics analysis of specific protein expression and oxidative modification in aged mice brain – insight into the mechanism of compensation of activity lost by oxidative modification. Neurobiology of Aging. 27:1010-19.
21. Rukhsana Sultana, Debra Boyd-Kimball, H. Fai Poon, Jain Cai, William M. Pierce, John B. Klein, William R Markesbery and D. Allan Butterfield, (2006) Oxidative modification and down-regulation of PIN-1 in Alzheimer’s disease: a redox proteomics analysis. Neurobiology of Aging. 27:918-925.
22. Andre Langer, H. Fai Poon, Gerald Munch, Bert C. Lynn, Thomas Arendt, and D. Allan Butterfield, (2006) Identification of AGE-Modified Proteins in SH-SY5Y and OLN-93 Cells. Neurotoxicity Research. 9:255-268.
23. Debra Boyd-Kimball, H. Fai Poon, Jon B. Klein, Christopher D. Link and D. Allan Butterfield, (2006) Proteomic identification of proteins specifically oxidized in C. elegans expressing human Ab(1-42). Neurobiology of Aging. 27, 1239-1249.
24. Rukhsana Sultana, Debra Boyd-Kimball, H. Fai Poon, Jain Cai, William M. Pierce, Jon B. Klein and D. Allan Butterfield, (2006) Regional redox proteomics to identify oxidized proteins in Alzheimer’s disease brain: an approach to understand pathological and biochemical alterations in AD. Neurobiology of Aging. 27, 1564-1576.
25. H. Fai Poon, Laila Abdullah, Myles A. Mullan, Michael J. Mullan, Fiona C. Crawford, (2007) Cocaine-Induced Oxidative Stress Precedes Cell Death in Human Neuronal Progenitor Cells.  Neurochemistry International. 50, 69-73.
26. Radhika Vaishnav, Marilyn Getchell, H. Fai Poon, Kara Barnett, Samuel Hunter, William Pierce, Jon Klein, D. Allan Butterfield, Thomas Getchell, (2007) Oxidative Stress in the Aging Murine Olfactry Bulb: Redox Proteomics and Cellular Localization. Journal of Neuroscience Research. 85, 373-385.
27. D. Allan Butterfield, Ana Gnjec, H. Fai Poon, Alessandra Castegna, William M. Pierce, Jon B. Klein, Ralph N Martins, (2007) Redox Proteomics Identification of Oxidatively Modified Brain Proteins in Inherited Alzheimer's Disease: An Initial Assessment. Journal of Alzheimer’s Disease. 10, 391-397.
28. H. Fai Poon, Laila Abdullah, Jon Reed, Sarah M. Doore, Cyndi Laird, Venkat Mathura, Michael Mullan, Fiona Crawford, (2007), Improving Image Analysis in 2DGE-based Redox Proteomics by Labeling Protein Carbonyl with Fluorescent Hydroxylamine, Biological Procedure Online, 9, 65-72.
29. Li Fan, YaYa Liu, WeiYan Zhang, XianCun Deng, H. Fai Poon, Wen-Song Tan, Xu-Ping Liu (2015) Chinese hamster ovary cell performance enhanced by a rational divide-and-conquer strategy for chemically defined medium development.Journal of Bioscience Bioengineering. 120,690-6.
30. Jintao Liu, Yaya Liu, Li Fan, Xinning Chen, Dongdong Hu, Xiancun Deng, Liang Zhao, H.Fai Poon, Haibin Wang, Xuping Liu, Wen-Song Tan,(2015), Galactose supplementation enhance sialylation of recombinant Fc-fusion protein in CHO cell: an insight into the role of galactosylation in sialylation.World Journal of Microbiololgy & Biotechnology. 31,1147-56.
31. Jintao Liu, Xinning Chen, Li Fan, XianCun Deng, H. Fai Poon, Wen-Song Tan, Xu-Ping Liu (2015) Monitoring sialylation levels of Fc-fusion protein using size-exclusion chromatography as a process analytical technology tool.Biotechnol Lett. 37 1371-7.
32. Lijuan Shen, Xu Yan, Lei Nie, Wenyan Xu, Shiwei Miao, Haibin Wang, H. Fai Poon, Haibin Qu, Chemometric identification of canonical metabolites during process parameters optimization of Chinese hamster ovary (CHO) cell culture(submitted)