Ying-Yong Zhao
Ying-Yong Zhao
Professor

Department of Traditional Chinese Medicine
The School of Life Sciences
Northwest University
China.

Education

05/2014-05/2015 Visiting Scholar Division of Nephrology and Hypertension, Department of Medicine, School of Medicine, University of California, Irvine, USA (Dr. Nosratola D Vaziri lab)
07/2012-08/2014 Postdoctor Department of Pharmacology, School of Pharmacy, The Fourth Military Medicinal University, China.
09/2007-07/2010 PhD, MD Department of Traditional Chinese Medicine, The School of Life Sciences, Northwest University, China.

 

Biography

Research Interest

My research focused on chronic kidney disease and therapeutic effect of natural medicines by pharmacology, biochemistry, metabolomics and lipidomics techniques. I also am studying the oxidative stress, inflammation, and pro-fibrotic pathways of chronic kidney disease and tubulo-interstitial diseases, molecular biology of kidney gene expression.

  1. Bioactive screening of diuretic form natural medicines
  2. Pharmacology and pharmacokinetics in chronic kidney disease
  3. Metabolomics and lipidomics in chronic kidney disease

Professional Activities:

Honors and Awards:

  1. National Excellent Doctoral Dissertation Nomination Award from Ministry of Education of China
  2. New Century Excellent Talents in University from Ministry of Education of China
  3. The Chinese Pharmaceutical Association Sanofi Young biological drugs Award
  4. The Ninth Youth S&T Awards of Shaanxi
  5. The Chinese Pharmacological Society Fifteenth SERVIER Youth Pharmacology Worker Award
  6. The Second Award of Science and Technology of Shaanxi Province

 

Publications

Review or Invited Review

  1. Ying-Yong Zhao*, Xian-Long Cheng, Rui-Chao Lin. Lipidomics applications for discovering biomarkers of diseases in clinical chemistry. International review of cell and molecular biology 2014; 313: 1–26. [IF=4.970]
  2. Ying-Yong Zhao*, Rui-Chao Lin. Metabolomics in nephrotoxicity. Advances in Clinical Chemistry 2014; 65:69–89. [IF=4.302]
  3. Hua Chen, Hua Miao, Ya-Long Feng, Ying-Yong Zhao*, Rui-Chao Lin. Metabolomics in dyslipidemia. Advances in Clinical Chemistry 2014; 66:101–119. [IF=4.302]
  4. Ying-Yong Zhao*, Nosratola D. Vaziri, Rui-Chao Lin. Lipidomics: new insight into kidney disease. Advances in Clinical Chemistry 2015; 68: 153–175. [IF=4.302]
  5. Ying-Yong Zhao*. Metabolomics in chronic kidney disease. Clinica Chimica Acta 2013;422: 59–69. [IF=2.764]
  6. Ying-Yong Zhao*. Traditional uses, phytochemistry, pharmacology, pharmacokinetics and quality control of Polyporus umbellatus (Pers.) Fries: A review. Journal of Ethnopharmacology 2013; 194(1):35–48. [IF=2.998]
  7. Ying-Yong Zhao*, Rui-Chao Lin. UPLC–MSE application in disease biomarker discovery: the discoveries in proteomics to metabolomics. Chemico-Biological Interactions 2014; 215(1):7–16. [IF=2.577]
  8. Ying-Yong Zhao*, Shao-Ping Wu, Shuman Liu, Yongmin Zhang, Rui-Chao Lin. Ultra-performance liquid chromatography-mass spectrometry as a sensitive and powerful technology in lipidomic applications. Chemico-Biological Interactions 2014; 220:181–192. [IF=2.577]
  9. Ying-Yong Zhao*, Xian-Long Cheng, Nosratola D. Vaziri, Shuman Liu, Rui-Chao Lin. UPLC-based metabonomics applications for discovering biomarkers of diseases in clinical chemistry. Clinical Biochemistry 2014; 47(15):16-26. [IF=2.606]
  10. Ting Tian, Hua Chen, Ying-Yong Zhao*. Traditional uses, phytochemistry, pharmacology, toxicology and quality control of Alisma orientale (Sam.) Juzep: A review. Journal of Ethnopharmacology 2014; 158: 373–387. [IF=2.998]
  11. Ying-Yong Zhao*, Xian-long Cheng, Rui-Chao Lin, Feng Wei. Lipidomics applications for diseases biomarker discovery in mammal models. Biomarkers in Medicine 2015; 9(2):153–168. [IF=2.646]
  12. Nosratola D. Vaziri, Ying-Yong Zhao, Madeleine V Pahl. Altered intestinal microbial flora and impaired epithelial barrier structure and function in CKD: the nature, mechanisms, consequences and potential treatment. Nephrology Dialysis Transplantation 2015, Accepted. [IF=3.577]

Research Articles

  1. Ying-Yong Zhao*, Xian-Long Cheng, Feng Wei, Xu Bai, Xiao-Jie Tan, Rui-Chao Lin, Qibing Mei. Intrarenal metabolomic investigation of chronic kidney disease and its TGF-β1 mechanism in induced-adenine rats using UPLC Q-TOF/HS-MS/MSE. Journal of Proteome Research 2013;12(2):692–703. [IF=5.001]
  2. Ying-Yong Zhao, Xuefeng Shen, Xu Chao, Charlene C. Ho, Xian-Long Cheng, Yongmin Zhang, Rui-Chao Lin, Ke-Jun Du, Wen-Jing Luo, Jing-Yuan Chen. Ergosta-4,6,8(14),22-tetraen-3-one induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Biochimica et Biophysica Acta (BBA) - General Subjects 2011;1810(4):384–390. [IF=5.000]
  3. Yang Sun, Yingyong Zhao*. Enhanced pharmacokinetics and anti-tumor efficacy of PEGylated liposomal rhaponticin and plasma protein binding ability of rhaponticin. Journal of Controlled Release 2013;172(1): e82-e83. [IF=7.261]
  4. Ying-Yong Zhao, Xiang-Yang Qin, Xian-Long Cheng, Xue-Ying Liu, Rui-Chao Lin. Rapid resolution liquid chromatography-mass spectrometry and high performance liquid chromatography-fluorescence detection for metabolism and pharmacokinetic studies of ergosta-4,6,8(14),22-tetraen-3-one. Analytica Chimica Acta 2010;675(2):199–206. [IF=4.310]
  5. Ying-Yong Zhao, Ya-Long Feng, Xu Bai, Xiao-Jie Tan, Rui-Chao Lin, Qibing Mei. Ultra performance liquid chromatography-based metabonomic study of therapeutic effect of the surface layer of Poria cocos on adenine-induced chronic kidney disease provides new insight into anti-fibrosis mechanism. Plos One 2013; 8(3): e59617. [IF=3.534]
  6. Ying-Yong Zhao*, Hua Chen, Ting Tian, Dan-Qian Chen, Xu Bai, Feng Wei. A pharmaco-metabonomic study on chronic kidney disease and therapeutic effect of ergone by UPLC-QTOF/HDMS. Plos One 2014; 9(12): e115467. [IF=3.234]
  7. Ying-Yong Zhao*, Ya-Long Feng, Xiao Du, Zhi-Hui Xi, Xian-Long Cheng, Feng Wei. Diuretic activity the ethanol and aqueous extracts of the surface layer of poria cocos in rat. Journal of Ethnopharmacology 2012;144(3):775–778. [IF=3.728]
  8. Ying-Yong Zhao*, Qi Su, Xian-Long Cheng, Xiao-Jie Tan, Xu Bai, Rui-Chao Lin. Pharmacokinetics, bioavailability, and metabolism of rhaponticin in rat plasma by UHPLC–Q–TOF/MS and UHPLC–DAD–MSn. Bioanalysis 2012;4(6):713–723. [IF=3.253]
  9. Ying-Yong Zhao*, Xian-Long Cheng, Feng Wei, Xin-Yue Xiao, Rui-Chao Lin. Serum metabonomics study of adenine-induced chronic renal failure rat by ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Biomarkers 2012;17(1):48–55. [IF=2.522]
  10. Ying-Yong Zhao*, Jing Liu, Xian-Long Cheng, Xu Bai, Rui-Chao Lin. Urinary metabonomics study on biochemical changes in an experimental model of chronic renal failure by adenine based on UPLC Q-TOF/MS. Clinica Chimica Acta 2012;413(5–6):642–649. [IF=2.850]
  11. Ying-Yong Zhao*, Xian-Long Cheng, Feng Wei, Xu Bai, Rui-Chao Lin. Ultra performance liquid chromatography coupled with electrospray and atmospheric pressure chemical (ESCi) ionization-quadrupole time-of-flight mass spectrometry with novel mass spectrometryElevated Energy (MSE) data collection technique: Determination and pharmacokinetics, tissue distribution and biliary excretion study of ergone in rat. Journal of Separation Science 2012;35(13):1619–1629. [IF=2.733].
  12. Ying-Yong Zhao*, Xian-Long Cheng, Ji-Hong Cui, Xing-Rong Yan, Feng Wei, Xu Bai, Rui-Chao Lin. Effect of ergosta-4,6,8(14),22-tetraen-3-one (ergone) on adenine-induced chronic renal failure rat: A serum metabonomics study based on ultra performance liquid chromatography/high-sensitivity mass spectrometry coupled with MassLynx i-FIT algorithm. Clinica Chimica Acta 2012;413(19–20):1438–1445. [IF=2.850]
  13. Ying-Yong Zhao*, Xian-Long Cheng, Charlene C. Ho, Feng Wei, Rui-Chao Lin, Yongmin Zhang. Pharmacokinetics of ergosterol in rats using rapid resolution liquid chromatography–atmospheric pressure chemical ionization multi-stage tandem mass spectrometry and rapid resolution liquid chromatography/tandem mass spectrometry. Journal of Chromatography B 2011;879(21):1945 –1953. [IF=3.057]
  14. Ying-Yong Zhao*, Li Zhang, Jia-Rong Mao, Xiao-Hong Cheng, Rui-Chao Lin. Ergosta-4,6,8(14),22-tetraen-3-one isolated from Polyporus umbellatus prevents early renal injury in aristolochic acid-induced nephropathy rats. Journal of Pharmacy and Pharmacology 2011;63(12):1581–1561. [IF=2.175]
  15. Yingyong Zhao, Lili Wang, Hua Miao, Charlene C. Ho, Jing Li, Xianlong Cheng, Ruichao Lin. LC method for the determination of rhaponticin in rat plasma, faeces and urine for application to pharmacokinetic studies. Chromatographia 2011;73(5–6):599–603. [IF=1.195]
  16. Ying-Yong Zhao, Xian-Long Cheng, Yongmin Zhang, Xu Chao, Rui-Chao Lin. A fast and sensitive HPLC-MS/MS analysis and preliminary pharmacokinetic characterization of ergone in rats. Journal of Chromatography B 2010;878(1):29–33. [IF=2.971]
  17. Ying-Yong Zhao, Xu Chao, Yongmin Zhang, Rui-Chao Lin. Cytotoxic steroids from Polyporus umbellatus. Planta Medica 2010;76(15):1755–1758.[IF=2.369]
  18. Ying-Yong Zhao, Xian-long Cheng, Yongmin Zhang, Ye Zhao, Rui-chao Lin. Simultaneous determination of eight major steroids from Polyporus umbellatus by high-performance liquid chromatography coupled with mass spectrometry detections. Biomedical Chromatography 2010;24(2):222–230. [IF=1.545]
  19. Ying-Yong Zhao, Xiang-Yang Qin, Yongmin Zhang, Rui-chao Lin, Xiao-Ye Li. Quantitative HPLC method and pharmacokinetic studies of ergosta-4,6,8(14),22-tetraen-3-one, a natural product with diuretic activity from Polyporus umbellatus. Biomedical Chromatography 2010;24(10):1120–1124. [IF=1.545]
  20. Ying-Yong Zhao, Xian-long Cheng, Ren-ming Xie, Xu Chao,Yongmin Zhang, Rui-chao Lin. Bioactivity-directed isolation, identification of diuretic compounds from Polyporus umbellatus. Journal of Ethnopharmacology 2009;126(1):184–187. [IF=3.728]
  21. Ying-Yong Zhao, Yong-min Zhang, Rui-chao Lin. An expeditious HPLC method to distinguish Aconitum kusnezoffii from related species. Fitoterapia 2009;80(6):333–338. [IF=2.139]
  22. Ying-Yong Zhao, Ye Zhao, Yong-min Zhang, Rui-chao Lin. Qualitative and quantitative analysis of diuretic component ergone in Polyporus umbellatus by HPLC with fluorescence detection and HPLC-APCI-MS/MS. harmazie 2009;64(6):366–370. [IF=0.812]
  23. Ying-Yong Zhao, Libin Yang, Minchang Wang, Lili Wang , Xian-long Cheng, Rui-chao Lin. 1β-hydroxylfriedelin, a new natural pentacylic triterpene from the sclerotia of Polyporus umbellatus. Journal of Chemical Research 2009;11:699–701. [IF=0.550]
  24. Ying-Yong Zhao, Xiang-Yang Qin, San-Ping Chen, Yongmin Zhang, Rui-Chao Lin. Crystal and molecular structure of rhaponticin from Rheum hotaoense. Journal of Chemical Crystallography 2011;41(3):409–414. [IF=0.566]
  25. Ying-Yong Zhao*, Xuefeng Shen, Xian-Long Cheng, Feng Wei, Xu Bai, Rui-Chao Lin. Urinary metabonomics study on the protective effects of ergosta-4,6,8(14),22-tetraen-3-one on chronic renal failure in rats using UPLC Q-TOF/MS and a novel MSE data collection technique. Process Biochemistry 2012;47(12):1980–1987. [IF=3.225]
  26. Ying-Yong Zhao*, Xian-Long Cheng, Feng Wei, Xu Bai, Rui-Chao Lin. Application of faecal metabonomics on an experimental model of tubulointerstitial fibrosis by ultra performance liquid chromatography/high-sensitivity mass spectrometry with MSE data collection technique. Biomarkers 2012;17(8):721–729. [IF=2.215]
  27. Ying-Yong Zhao*, Li Zhang, Ya-Long Feng, Dan-Qian Chen, Zhi-Hui Xi, Xiao Du, Xu Bai, Rui-Chao Lin. Pharmacokinetics of 2,3,5,4’-tetrahydroxystilbene-2-O-β-D-glucoside in rat using ultra-performance LC-quadrupole TOF-MS. Journal of Separation Science 2013;36(5):863 –871. [IF=2.733]
  28. Ying-Yong Zhao*, Xian-Long Cheng, Feng Wei, Xiao-Qiang Han, Xin-Yue Xiao, Rui-Chao Lin. Pharmacokinetics, bioavailability, and metabolism of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside in rats by ultra performance liquid chromatography–quadrupole time-of-flight mass spectrometry and high performance liquid chromatography-ultraviolet detection. Journal of Liquid Chromatography & Related Technologies 2013;36(6):717–730. [IF=0.706]
  29. Ying-Yong Zhao*, Li Zhang, Feng-Ya Long, Xian-Long Cheng, Xu Bai, Feng Wei, Rui-Chao Lin. UPLC-Q-TOF/HSMS/MSE-based metabonomics for adenine-induced changes in metabolic profiles of rat faeces and intervention effects of ergosta-4,6,8(14),22-tetraen-3-one. Chemico-Biological Interactions 2013;301(1–3):31–38. [IF=3.060]
  30. Ying-Yong Zhao*, Ping Lei, Dan-Qian Chen, Ya-Long Feng, Xu Bai. Renal metabolic profiling of early renal injury and renoprotective effects of poria cocos epidermis using UPLC Q-TOF/HSMS/MSE. Journal of Pharmaceutical and Biomedical Analysis 2013; 81–82(1):202–209. [IF=2.829]
  31. Ying-Yong Zhao*, Hai-Tao Li, Ya-Long Feng, Xu Bai, Rui-Chao Lin. >Urinary metabonomic study of the surface layer of poria cocos as an effective treatment for chronic renal injury in rats. Journal of Ethnopharmacology 2013;148(2):403–410. [IF=3.728]
  32. Ying-Yong Zhao*, Dan-Dan Tang, Hua Chen, Jia-Rong Mao, Xu Bai, Xiao-Hong Cheng, Xin-Yue Xiao. Urinary metabolomics and biomarkers of aristolochic acid nephrotoxicity by UPLC-QTOF/HDMS. Bioanalysis 2015; 7(6):685–700. [IF=3.027]
  33. Ying-Yong Zhao, Shuang-Qing Zhang, Feng Wei, Yu-Ming Fan, Feng Sun, Shuhua Bai. Quality Control of Natural Product Medicine and Nutrient Supplements 2014. Journal of Analytical Methods in Chemistry 2014;2014: 109068. [IF=0.948]
  34. Shuang-Qing Zhang, Feng Wei, Yu-Ming Fan, Feng Sun, Ying-Yong Zhao*, Shuhua Bai. Quality Control of Natural Product Medicine and Nutrient Supplements. Journal of Analytical Methods in Chemistry 2013;2013:182573. [IF=0.948]
  35. Lu Yin, Ya-Long Feng, Ting Tian, Hua Chen, Dan-Qian Chen, Ying-Yong Zhao*. Diuretic activity in rats: the ethanol and aqueous extracts of rhubarb. FASEB JOURNAL 2014; 28 (1): 657.1. [IF=5.480]
  36. Yang Sun, Yingyong Zhao (co-first author), Guobo Li, Shengyong Yang, Xiaoyun Hu, Jun Fan. Studies of Interaction between Ergosta-4,6,8(14),22-tetraen-3-one (Ergone) and human serum albumin by molecular spectroscopy and modeling. Journal of the Chinese Chemical Society-Taipei 2011;58(5):602–610. [IF=0.678]
  37. Hua Miao, Hua Chen, Songwen Pei, Xu Bai, Nosratola D Vaziri, Ying-Yong Zhao*. Plasma lipidomics reveal profound perturbation of glycerophospholipids, fatty acids, and sphingolipids in diet-induced hyperlipidemia. Chemico-Biological Interactions 2015; 228: 79–87. [IF=2.982]
  38. Dan-Qian Chen, Ya-Long Feng, Ting Tian, Xiang-Yang Qin, Ying-Yong Zhao*. Cloud-point extraction combined with liquid chromatography for determination of ergosterol, a natural product with diuretic activity, in rat plasma, urine and faeces. Journal of Analytical Methods in Chemistry 2013;2013:479056. [IF=0.948]
  39. Hua Chen, Bin Yuan, Hua Miao, Yi Tan, Xu Bai, Ying-Yong Zhao*, Yun Wang. Urine metabolomics reveals new insights into hyperlipidemia and therapeutic effect of rhubarb. Analytical Methods 2015;7(7):3113–3123. [IF=1.938]
  40. Ya-Long Feng, Ping Lei, Hua Chen, Ting Tian, Lu Yin, Dan-Qian Chen, Qibing Mei, Ying-Yong Zhao*, Rui-Chao Lin. Diuretic activity of some fractions of the epidermis of Poria cocos. Journal of Ethnopharmacology 2013, 150(3):1114-1118. [IF=3.728]
  41. Ya-Long Feng, Hua Chen, Ting Tian, Dan-Qian Chen, Ying-Yong Zhao*, Rui-Chao Lin. Diuretic and anti-diuretic activities of the ethanol and aqueous extracts of Alismatis Rhizoma. Journal of Ethnopharmacology 2014, 154(2):386-390. [IF=3.728]
  42. Dan-Qian Chen, Ya-Long Feng, Ting Tian, Hua Chen, Lu Yin, Ying-Yong Zhao*, Rui-Chao Lin. Diuretic and anti-diuretic activities of fractions of Alismatis Rhizoma. Journal of Ethnopharmacology 2014;157:114–118. [IF=3.728]
  43. Yang Sun, Chun-Mei Hu, Guo-Bo Li, Sheng-Yong Yang, Lu-Sha Liu, Chun-Lei Tan, Song Wei, Xaio-Yun Hu, Ying-Yong Zhao*, Jun Fan. Studies on the binding of iosalantolactone to human serum albumin by molecular spectroscopy and modeling. Indian Journal of Chemistry 2011;50A:1477–1484. [IF=0.891]
  44. Lushu Liu, Yang Sun, Song Wei, Xiaoyun Hu, Yingyong Zhao*, Jun Fan. Solvent effect on the absorption and fluorescence of ergone: Determination of ground and excited state dipole moments. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2012;86:120–123. [IF=2.098]
  45. Yang Sun, Yingyong Zhao*. Enhanced pharmacokinetics and anti-tumor efficacy of PEGylated liposomal rhaponticin and plasma protein binding ability of rhaponticin. Journal of Nanoscience and Nanotechnology 2012;12(10):7677–7684. [IF=1.563]
  46. Yang Sun, Zhen Ji, Yingyong Zhao*, Xuhua Liang, Xiaoyun Hu, Jun Fan. Enhanced distribution and anti-tumor activity of ergosta-4,6,8(14),22-tetraen-3-one by polyethylene glycol liposomalization. Journal of Nanoscience and Nanotechnology 2013;13(2):1435–1439. [IF=1.563]
  47. Xuhua Liang, Yang Sun, Wenyuan Zeng, Lusha Liu, Xuan Ma, Yingyong Zhao*, Jun Fan. Synthesis and biological evaluation of a folate-targeted rhaponticin conjugate. Bioorganic & Medicinal Chemistry 2013;21(1):178–185. [IF=2.951]
  48. Xuhua Liang, Yang Sun, Lusha Liu, Xuan Ma, Xiaoyun Hu, Jun Fan, Yingyong Zhao*. Folate-functionalized nanoparticles for controlled ergosta-4,6,8(14),22-tetraen-3-one delivery. International Journal of Pharmaceutics 2013;441(1–2):1–8. [IF=3.785]
  49. Chang Wang, Mei-Xia Meng, Xu-Lei Tang, Ke-Ming Chen, Li Zhang, Wei-Ning Liu, Ying-Yong Zhao*. The proliferation, differentiation and mineralization effects of puerarin on osteoblasts in vitro. Chinese Journal of Natural Medicines 2014; 12(6):436-442. [IF=1.114]
  50. Ying-Yong Zhao*, Ya-Long Feng, Ren-Ming Xie, Rui-Chao Lin. Polyporus umbellatus (Pers.) Fries: Traditional uses, phytochemistry, pharmacology, pharmacokinetics and quality control: A review. Acta Pharmacologia Sinica 2013; 34(Supplemant):35. [IF=2.083]
  51. Ying-Yong Zhao, Shuman Liu, Hua Chen, Ya-Long Feng, Ruichao Lin,Wei Ling Lau, Nosratola D. Vaziri. A pharmaco-metabolomic study of chronic aristolochic acid nephropathy. Journal of the American Society of Nephrology 2014; 25 (Supplemant): 437A. [IF=9.466]
  52. Ying-Yong Zhao, Ya-Long Feng, Hua Chen, Shuman Liu, Ruichao Lin. Urinary metabonomic study of Rhubarb as an effective treatment for chronic renal injury in rats. Journal of the American Society of Nephrology 2014; 25 (Supplemant): 280A. [IF=9.466]
  53. Nosratola D. Vaziri, Shuman Liu, Seyed H Farzane, Sohrab Nazertehrani, Mahyar Khazaeli, Ying-Yong Zhao. Dose-dependent deleterious and salutary actions of Nrf2 inducer, dh404, in chronic kidney disease. Free Radical Biology & Medicine 2015 Accepted. [IF=5.710]
  54. Zhi-Hao Zhang, Ying-Yong Zhao, Xian-long Cheng, Zhong Dai, Chao Zhou, Xu Bai, Rui-Chao Lin. General toxicity of Pinellia ternate (Thunb.) Berit. in rat: A metabonomic method for profiling of serum metabolic changes. Journal of Ethnopharmacology 2013;149(1):303–310. [IF=3.728]
  55. Zhi-Hao Zhang, Ying-Yong Zhao, Xian-long Cheng, Rui-Chao Lin, Zhong Dai, Chao Zhou. Metabonomic study of biochemical changes in the rat urine induced by Pinellia ternata (Thunb.) Berit. Journal of Pharmaceutical and Biomedical Analysis 2013;85(1):186–193. [IF=2.967]
  56. Jian-Qiang Liu, Yun-Sheng Huang, Ying-Yong Zhao, Zhen-Bin Jia. Molecular tectonics of entangled metal-organic frameworks based on different conformational carboxylates mixed with a flexible N,N-Type ligand. Crystal Growth & Design 2011;11(2):569–574. [IF=4.720]
  57. Xu Chao, Lili Guo, Ying-Yong Zhao, Kai Hua, Ming-Li Peng, Chao Chen, Ya-Li Cui. PEG-modified goldMag nanoparticles combined with the external magnetic field for local drug delivery. Journal of Drug Targeting 2011;19(3):161–170. [IF=2.696]
  58. Yang Sun, Song Wei, Chen Yin, Lusha Liu, Chunmei Hu, Yingyong Zhao, Yanxi Ye, Xiaoyun Hu, Jun Fan. Synthesis and spectroscopic characterization of 4-butoxyethoxy-N-octadecyl-1,8-naphthalimide as a new fluorescent probe for the determination of proteins. Bioorganic & Medicinal Chemistry Letters 2011;21:3798–3804. [IF=2.554]
  59. Lusha Liu, Jun Fan, Chunmei Hu, Yang Sun, Xiaoyun Hu, Yingyong Zhao, Song Wei, Xuhua Liang. Studies on the Interaction between tubeimoside II and human serum albumin by spectroscopic methods. Acta Chimica Sinica 2011;69(21):2589–2596. [IF=0.533]
  60. Yang Sun, Yingyong Zhao, Lusha Liu, Song Wei, Xuhua Liang, Chunlei Tan, Xiaoyun Hu, Jun Fan. Studies on the fluorescence enhancement effect of ergosta-4,6,8(14),22-tetraen-3-one with serum albumin and Its application. Acta Chimica Sinica 2011;69(22):2703–2709. [IF=0.533]
  61. Xu Chao, Feng Shi, Ying-Yong Zhao, Ke Li, Ming-Li Peng, Chao Chen, Ya-Li Cui. Cytotoxicity of Fe3O4/Au composite nanoparticles loaded with doxorubicin combined with magnetic field. Pharmazie 2010;65(7):500–504. [IF=0.869]
  62. Yang Sun, Song Wei, Yingyong Zhao, Xiaoyun Hu, Jun Fan. Interactions between 4-(2-dimethylaminoethyloxy)-N-octadecyl-1,8-naphthalimide and serum albumins: Investigation by spectroscopic approach. Journal of Luminescence 2012;132 (4):879–886. [IF=2.102]
  63. Yang Sun, Zhen Ji, Xuehua Liang, Guobo Li, Shengyong Yang, Song Wei, Yingyong Zhao, Xiaoyun Hu, Jun Fan. Studies on the binding of rhaponticin with human serum albumin by molecularspectroscopy, modeling and equilibrium dialysis. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2012;87:171–178. [IF=2.098]
  64. Yang Sun, Song Wei, Yingyong Zhao, Xiaoyun Hu, Jun Fan. Characterization of the interaction between 4-(Tetrahydro-2-Furanmethoxy)-N-Octadecyl-1,8-Naphthalimide and human serum albumin by molecular spectroscopy and its analytical application. Applied Spectroscopy 2012;66(4):464–469. [IF=1.839]
  65. Sui-Hong Yan, Ying-Yong Zhao, Hai-Song Zeng, Yongmin Zhang, Rui-Chao Lin, Wen-Ji Sun. Chemical composition and antioxidant activities of extracts from Apocyni Veneti Folium. Natural Products Research 2012;26(7):600–608. [IF=0.906]
  66. Xian-Long Cheng, Feng Wei, Xin-Yue Xiao, Ying-Yong Zhao, Yan Shi, Wei Liu, Ping Zhang, Shuang-Cheng Ma, Shou-Sheng Tian, Rui-Chao Lin. Identification of five gelatins by ultra performance liquid chromatography/ time-of-flight mass spectrometry (UPLC/Q-TOF-MS) using principal component analysis. Journal of Pharmaceutical and Biomedical Analysis 2012;62:191–195 [IF=2.967]
  67. Xu Hua Liang, Yang Sun, Lu Sha Liu, Ying Yong Zhao, Xiao Yun Hu, Jun Fan. Regioselective synthesis and initial evaluation of a folate receptor targeted rhaponticin prodrug. Chinese Chemieal Letters 2012;23(10):1133–1136. [IF=0.978]
  68. Yang Sun, Shi-Sheng Sun, Ying-Yong Zhao, Jun Fan. Specific binding of tubeimoside-2 with proteins in hepatocarcinoma HepG2 cells: investigation by molecular spectroscopy. Journal of Applied Spectroscopy 2012;79(3):416–423. [IF=0.513]
  69. Yang Sun, Xuhua Liang, Yingyong Zhao, Jun Fan. A water-soluble, 1,8-naphthalimide based aggregation induced synchronous emission system for selective and sensitive recognition of casein. Analytical methods 2012;4(12):4284–4288. [IF=1.547]
  70. Yang Sun, Xuhua Liang, Yingyong Zhao, Jun Fan. Studies on the aggregation-Induced synchronous emission of 1,8-naphthalimide derivative to casein and its analytic application. Food Analytical Methods 2013;6(5):1253–1257. [IF=2.069]
  71. Yang Sun, Xuhua Liang, Yingyong Zhao, Jun Fan. Aggregation induced emission of 1,8-Naphthalimide probe with casein micelle: investigated by synchronous spectrographic method. Chemistry & Biodiversity 2013;10(9):1597–1605. [IF=1.804]
  72. Yang Sun, Yingyong Zhao, Xiaohui Yang. A simple and rapid spectrofluorimetric method for determining the pharmacokinetics and metabolism of rhaponticin in rat plasma, feces and urine using a cerium probe. Luminescence 2013;28(4):523–529. [IF=1.731]
  73. Yang Sun, Xuhua Liang, Yingyong Zhao, Jun Fan. Solvent effects on the absorption and fluorescence spectra of rhaponticin: Experimental and theoretical studies. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2013;102:194–199. [IF=2.098]
  74. Yang Sun, Xuhua Liang, Yingyong Zhao, Jun Fan. A sensitive spectrofluorometric method for determination of ergosta-4,6,8(14),22-tetraen-3-one in rat plasma, feces, and urine for application to pharmacokinetic studies using Cerium(III) as a probe. Applied Spectroscopy 2013;67(1):106–111. [IF=1.729]
  75. Xian-Long Cheng, Feng Wei, Jia Chen, Ming-hua Li, Lei Zhang, Ying-Yong Zhao, Xin-Yue Xiao, Shuang-cheng Ma, Rui-Chao Lin. Using the doubly charged selected ion coupled with MS/MS fragments monitoring (DCSI-MS/MS) mode for the identification of gelatin species. Journal of Analytical Methods in Chemistry 2014;2014:764397. [IF=0.565].

 

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