Education

Biography

Professor Akira Sugawara belongs to the Department of Molecular Endocrinology. He performed Postdoctoral Fellowship in William Chin’s laboratory at the Women’s Hospital/Harvard Medical School in Boston from 1991 to 1994. His major is general internal medicine, endocrinology and metabolism and hypertension and nephrology.

Research Interest

• Molecular Biology of Nuclear Hormone Receptors
• Etiology of High Blood Pressure
• Pathophysiology of Diabetic Nephropathy
• Gene Regulation of Aldosterone Synthesis
• Epigenetics of Hypertension and Diabetes Mellitus

Scientific Activities

Professional Experience

Other Activities

Professional Societies

Honors and Awards

Publications

1. Nakamura T, Yoshikawa T, Noguchi N, Sugawara A, Kasajima A, Sasano H, Yanai K. The expression and function of histamine H3 receptor in pancreatic β-cells. Br J Pharmacol. 2014; 171: 171-185.
2. Yagishita Y, Fukutomi T, Sugawara A, Kawamura H, Takahashi T, Pi J, Uruno A, Yamamoto M. Nrf2 protects pancreatic β-cells from oxidative and nitrosative stress in diabetic model mice. Diabetes. 2014; 63: 605-618.
3. Ito R, Katsura S, Shimada H, Tsuchiya H, Hada M, Okumura T, Sugawara A, Yokoyama A. TET3-OGT interaction increases the stability and the presence of OGT in chromatin. Genes Cells. 2014; 19: 52-65.
4. Matsuda K, Uruno A, Kogure N, Sugawara K, Shimada H, Nezu M, Saito-Ito T, Iki Y, Kudo M, Shimizu K, Sato I, Yoshikawa T, Satoh F, Ito R, Yokoyama A, Rainey WE, Saito-Hakoda A, Ito S, Sugawara A. Angiotensin II receptor blockers differentially affect CYP11B2 expression in human adrenal H295R cells. Mol Cell Endocrinol. 2014; 383: 60-68.
5. Felizola SJ, Nakamura Y, Ono Y, Kitamura K, Kikuchi K, Onodera Y, Ise K, Takase K, Sugawara A, Hattangady N, Rainey WE, Satoh F, Sasano H. PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues. J Mol Endocrinol. 2014; 52: 159-167.
6. Nakamura Y, Hattangady NG, Ye P, Satoh F, Morimoto R, Ito-Saito T, Sugawara A, Ohba K, Takahashi K, Rainey WE, Sasano H. Aberrant gonadotropin-releasing hormone receptor (GnRHR) expression and its regulation of CYP11B2 expression and aldosterone production in adrenal aldosterone-producing adenoma (APA). Mol Cell Endocrinol. 2014; 384: 102-108.
7. Kudo M, Matsuda K, Sugawara K, Iki Y, Kogure N, Saito-Ito T, Shimizu K, Sato I, Takeo Yoshikawa T, Uruno A, Ito R, Yokoyama A, Saito-Hakoda A, Ito S, Sugawara A. ARB affects nicotine-induced gene expression profile in human coronary artery endothelial cells. World J Hypertens. 2014; 4: 7-14.
8.  Saito-Hakoda A, Kogure N, Yoshikawa T, Shimizu K, Iki Y, Sato I, Kudo M, Uruno A, Matsuda K, Parvin R, Sugawara K, Yokoyama A, Ito S, Sugawara A. Is heparan sulfate in the glomerular basement membrane necessary for the etiology of diabetic nephropathy? J Biomol Res Ther. 2014; 3: e127.
9. Kudo M, Satoh F, Aoki S, Morimoto R, Iwakura Y, Ono Y, Matsuda K, Sugawara A, Yoshida K, Sato K, Ito S. Assisting the diagnosis of Cushing syndrome by pattern recognition methods, using a combination of eight routine tests, and their multiple correlation with serum cortisol. Biomedicine & Aging Pathology. 2014; 4: 257-264.
10. Yokoyama A , Igarashi K, Sato T, Takagi K, Otsuka I. M, Shishido Y, Baba T, Ito I, Kanno J, Ohkawa Y, Morohashi K, Sugawara A. Identification of Myt1 as a subunit of the neural cell type-specific LSD1 complex. J Biol Chem. 2014; 289: 18152-18162.
11. Katsura S, Okumura T, Ito R, Sugawara A, Yokoyama A. Identification of posttranslational modifications in peroxisome proliferator-activated receptor γ using mass spectrometry. PPAR Res. 2014; 2014:468925. doi: 10.1155/2014/468925. Epub 2014 Jun 25.
12. Uruno A, Saito-Hakoda A, Yokoyama A, Kogure N, Matsuda K, Parvin R, Shimizu K, Sato I, Kudo M, Yoshikawa T, Kagechika H, Iwasaki Y, Ito S, Sugawara A. Retinoic acid receptor-α up-regulates proopiomelanocortin gene expression in AtT20 corticotroph cells. Endocr J. 2014; 61: 1105-1114.
13. Nakamura T, Yoshikawa T, Naganuma F, Mohsen A, Iida T, Miura Y, Sugawara A, Yanai K. Role of histamine H3 receptor in glucagon-secreting αTC1.6 cells. FEBS Open Bio. 2015; 5: 36-41.
14. Saito-Hakoda A, Uruno A, Yokoyama A, Shimizu K, Parvin R, Kudo M, Saito-Ito T, Sato I, Kogure N, Suzuki D, Shimada H, Yoshikawa T, Fujiwara I, Kagechika H, Iwasaki Y, Kure S, Ito S, Sugawara A. Effects of RXR agonists on cell proliferation/apoptosis and ACTH secretion/Pomc expression. PLoS One. 2015; 10: e0141960.
15. Ito R, Shimada H, Yazawa K, Sato I, Imai Y, Sugawara A, Yokoyama A. Hydroxylation of methylated DNA by TET1 in chondrocyte differentiation of C3H10T1/2 cells. Biochem Biophys Rep. 2016; 5: 134-140.