Nanomedicine and Nanosurgery-Sci Forschen

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Smart and Living Biomaterials Equipped with Active Therapeutics and Stem Cells for Regenerative Nanomedicine

  Keller L1      Wagner Q2     Benkirane-Jessel N1,2,3,*  

1INSERM “French National Institute of Health and Medical Research”; "Osteoarticular and Dental Regenerative Nanomedicine" Laboratory, UMR 1109, FMTS, Strasbourg, France
2Université de Strasbourg, Faculté de Chirurgie Dentaire de Strasbourg, France
3ARTiOS Nanomed Start up, Spin off from INSERM, SAS, Strasbourg, France

*Corresponding author: Benkirane-Jessel N, "Osteoarticular and Dental Regenerative Nanomedicine" Laboratory, INSERM “French National Institute of Health and Medical Research”; UMR 1109, FMTS, Strasbourg, France, Tel: (33)-3-68-85-33-76; E-mail:

Regenerative medicine is a branch of translational research in repair and tissue engineering, which deals with the process of replacing, engineering or regenerating human cells, tissues or organs to restore or establish normal function. This field holds the promise of engineering damaged tissues and organs via stimulating the body's own repair mechanisms to functionally heal previously irreparable tissues or organs.

Regenerative medicine refers to a group of biomedical approaches to clinical therapies that may involve the use of stem cells. Examples include the injection of stem cells or progenitor cells obtained through directed differentiation (cell therapies); the induction of regeneration by biologically active molecules administered alone or as a secretion by infused cells (immunomodulation therapy); and transplantation of in vitro grown organs and tissues (tissue engineering).

The emergence of nanotechnology can enable development of entirely new classes of bioactive devices that need precise intracellular delivery for more efficacies and less toxicities. While both organic and inorganic technologies are under development, controlled-release polymer technologies will likely continue to have the greatest clinical impact for the foreseeable future.

Engineering smart materials allow for novel medical therapies such as designing smart implant based drugs that target cells with improved specificity, resulting in decreased side effects for patients. Other advances are being made in sophisticated biomaterials for use in surgical implantations that are less invasive, leading to shorter recovery times and decreased risk of postoperative infections or other complications. Such innovations will improve the quality of life, extend life expectancies, and could reduce the overall cost of healthcare. Biomaterials play central roles in modern strategies in regenerative medicine and tissue engineering as designable biophysical and biochemical milieus that direct cellular behaviour and function.

Regenerative Nanomedicine is an exciting new field of inter disciplinary research that uses nanoscale technology or materials to seek ways to repair, replace, or regenerate cells, tissues, or organs. The work involves teamwork among researchers in the life, physical, and engineering sciences. The goal of this research is to develop clinical approaches to restore, replace, or enhance biological functions that have been lost due to disease, injury, or aging.

Recently, we have reported a "Smart Hybrid Materials Equipped with Nanoreservoirs of Therapeutics and stem cells". This unique nanotechnology strategy is used to entrap, protect, and stabilize therapeutic agents into polymer coatings acting as nanoreservoirs enrobing nanofibers of implantable membranes [1-3]. Upon contact with cells, therapeutic agents become available through enzymatic degradation of the nanoreservoirs. As cells grow, divide, and infiltrate deeper into the porous membrane, they trigger slow and progressive release of therapeutic agents that, in turn, stimulate further cell proliferation. This constitutes the first instance of a smart living nanostructured hybrid membrane for regenerative medicine [1,2,4,5]. The cell contact-dependent bioerodible nanoreservoirs described here will permit sustained release of drugs, genes, growth factors, etc., opening a general route to the design of sophisticated cell-therapy implants capable of robust and durable regeneration of a broad variety of tissues.

  1. Facca S, Mendoza-Palomares, Cortez C, Messadeq CN, Dierich A, et al. (2010) Active multilayered capsules for in vivo bone formation. Proc Natl Acad Sci USA 107: 3406-3411. [Ref.]
  2. Facca S, Lahiri D, Fioretti F, Messadeq N, Mainard D, et al. (2011) In vivo osseointegration of nano-designed composite coatings on titanium implants. ACS Nano 5: 4790-4799. [Ref.]
  3. Mendoza-Palomares C, Ferrand A, Facca S, Fioretti F, Ladam G, et al. (2012) Smart hybrid materials equipped by nanoreservoirs of therapeutics. ACS Nano 6: 483-490. [Ref.]
  4. Eap S, Ferrand A, Schiavi J, Keller L, Kokten T, et al. (2014) Collagen implants equipped by “fishscale”- like nanoreservoirs of growth factors for bone regeneration. Nanomedicine (Lond) 9: 1253-1261. [Ref.]
  5. Keller L, Schiavi J, De Isla-Martinez N, Morand D, Mainard D, et al. (2015) Active and nanostructured collagen implant reinforced with human mesenchymal stem cells microtissues for bone regenerative nanomedicine. Nanomedicine 10: 753-763. [Ref.]

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Article Information

Aritcle Type: Editorial

Citation: Keller L, Wagner Q, Benkirane-Jessel N (2015) Smart and Living Biomaterials Equipped with Active Therapeutics and Stem Cells for Regenerative Nanomedicine. Int J Nanomed Nanosurg 1(2): doi

Copyright: © 2015 Keller L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Publication history: 

  • Received date: 23 October 2015

  • Accepted date: 31 October 2015

  • Published date: 5 Nov 2015