Education

1989 - 1995      Yamanashi Medical College

Biography

Dr. Ken-ichiro Inoue is currently, working as Professor in Center for Medical Science, International University of Health and Welfare, Japan. He has successfully completed his Administrative responsibilities as Professor of Department of Public Health and Molecular Toxicology, School of Pharmacy, Kitasato University, Japan. He has authored 121 research articles.

Research Interest

Environmental Immunotoxicology, Chemical and Atmospheric Research in Toxicology

Professional Activities:

Publications

1. Kasamatsu Y, Nakagawa N, Inoue K, Kawahito Y Kasamatsu Y, Hiraoka N,Yoshioka K, Yokoo S: Pretonitis due to Mycobacterium fortuitum infection following gastric cancer surgery. Intern Med 38(10): 833-836, 1999.
2. Inoue K, Yoshioka K, Kawahito Y, Kasamatsu Y, Hiraoka N, Yokoo S, Kondo M:　A case of flare-up of systemic lupus erythematosus and Sjogrem’s syndrome menifesting with cholecystitis secondary to pregnancy.  Jpn J Rheumatol 9: 195-202, 1999.
3. Yamada R, Sano H, Hla T, Hashiramoto A, Kawahito Y, Mukai S, Kohno M, Tsubouchi Y, Inoue M, Komatsu A, Inoue K, Kondo M : Selective inhibition of cyclooxygenase-2 with antisence oligodeoxynuceotide restricts induction of rat adjuvant-induced arthritis.  Biochem Biopyhs Res Commun 269(2): 415-421, 2000.
4. Tsubouchi Y, Mukai S, Kawahito Y, Yamada R, Kohno M, Inoue K, Sano H: Meloxicam inhibits the growth of non-small cell lung cancer.  Anticancer Res 20(5A): 2867-2872, 2000.
5. Kawahito Y, Kondo M, Tsuboi Y, Hashiramoto A, Bishop-Bailey D, Inoue K, Kohno M, Yamada R, Hla T, Sano H : 15-deoxy-delta (12, 14)-PGJ (2) induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats.  J Clin Invest 106(2): 189-197, 2000.
6. Tsubouchi Y, Sano H, Kawahito Y, Mukai S. Yamada R, Kohno M, Inoue K, Hla T, Kondo M: Inhibitation of human lung cancer cell growth by the peroxisome proliferator-activated receptor-γ agonists through induction of apoptosis. Biochem Biophys Res Commun 270(2): 400-405, 2000.
7. Inoue K, Kawahito Y, Tsubouchi Y, Kohno M, Yoshikawa T, Sano H: Increased fernesoid X receptor expression in non-small cell lung cancer. Jpn J Lung Cancer 41: 293-297, 2001.
8. Tsubouchi Y, Kawahito Y, Khno M, Inoue K, Hla T, Sano H: Feedback control of the arachidonate cascade in rheumatoid synoviocytes by 15-deoxy-Delta (12, 14) prostaglandin J2.  Biochem Biophys Res Commun 283(4): 750-755, 2001.
9. Inoue K, Kusaka Y, Kubo T, Elenkov IJ, Chrousos GP, Kondo M, Sano H:Urocortin expression in synovium of patients with rheumatoid arthritis and osteoarthritis: relation to inflammatory activity. J Clin Endocrinol Metab 86(9): 4344-4352, 2001.
10. Inoue K, Kawahito Y, Tsubouchi Y, Kohno M, Yoshimura R, Yoshikawa T, Sano H: Expression of peroxisome proliferator-activated receptor gamma in renal cell carcinoma and growth inhibition by its agonists. Biochem Biophys Res Commun 287(3): 727-732, 2001.
11. Inoue K, Kawahito Y, Tsubouchi Y, Yamada R, Kohno M, Hosokawa Y, Katoh D Bishop-Bailey D, Hla T, Sano H: Expression of peroxisome proliferator-activated receptor (PPAR)-gamma in human lung cancer. Anticancer Res 21(4A): 2471-2476, 2001 
12. Kohno M, Aikawa Y, Tsubouchi Y, Hashiramoto A, Yamada R, Kawahito Y, Inoue K, Kusaka Y, KondoM ,Sano H: Inhibitory effect of T-614 on tumor necrosis factor-kappa B activation in cultured human synovial cells. J Rheumatol 28(12):2591-2596, 2001.
13. Takano H, Yanagisawa R, Ichinose T, Sadakane K, Inoue K, Yoshida S, Takeda K, Yoshino S, Yoshikawa T, Morita M: Lung expression of cytochrome P450 1A1 as a possible biomarker of exposure to diesel exhaust particles. Arch Toxicol 76(3): 146 -151, 2002.
14. Takano H, Inoue K, Katada K, Yoshikawa T: Stenosis of pyloric antrum in a patient with systemic lupus erythematosus. Endoscopy 34(10), 846, 2002.
15. Tsunoda S, Takano H, Inoue K, Yoshikawa T: A case of lupus peritonitis and cystitis after ovulation induction therapy. Am J Obstet Gynecol 189(3): 888-889, 2003.
16. Inoue K, Takano H, Yanagisawa R, Morita M, Ichinose T, Sadakane K, Yoshino S, Yamaki K,Uchiyama K,　Yoshikawa T:  Effect of 15-deoxy-△12, 14-PGJ2 on acutelung injury induced by lipopolysaccaride in mice. Eur J Pharmacol 481(2-3): 261-269, 2003.
17. Yanagisawa R, Takano H, Inoue K, Ichinose T, Sadakane K, Yoshino S, Yamaki K, Kumagai Y, Uchiyama K, Yoshikawa T, Morita M: Enhancement of acute lung injury related to bacterial endotoxin by components of diesel exhaust particles. Thorax 58(7): 605-612, 2003.
18. Sanbongi C, Takano H, Osakabe N, Sasa N, Natsume M, Yanagisawa R, Inoue K, Yoshikawa T: Rosmarinic acid inhibits lung injury induced by diesel exhaust particles. Free Radic Biol Med 34(8): 1060-1069, 2003.
19. Yoshimura R, Inoue K, Kawahito Y, Mitsuhashi M, Tsuchida K, Matsuyama M, Sano H, Nakatani T: Expression of 12-lipoxygenase in human renal cell carcinoma and growth prevention by its inhibitor. Int J Mol Med 13(1): 41-46, 2003.
20. Yanagisawa R, Takano H, Inoue K, Ichinose T, Sadakane K, Yoshida S, Takeda K, Yoshino S, Yamaki K, Kumagai Y, Yoshikawa T: Complementary DNA microarray analysis in acute lung injury induced by lipopolysaccharide and diesel exhaust particles. Exp Biol Med 229(10), 1081-1087, 2003.
21. Takano H, Inoue K, Yoshikawa T, Yanagisawa R, Satoh M, Shimada A, Morita T, Sawada M, Nakamura K, Sanbongi C: Protective role of metallothionein in acute lung injury induced by bacterial endotoxin. Thorax 59(12), 1057-1062, 2004.
22. Naito Y, Takagi T, Uchiyama K, Kuroda M, Kokura S, Ichikawa H, Yanagisawa R, Inoue K, Takano H, Satoh M, Yoshida N, Okanoue T, Yoshikawa T: Reduced intestinal inflammation induced by dextran sodium sulfate in interleukin-6-deficient mice. Int J Mol Med 14(2): 191-196, 2004.
23. Inoue K, Takano H, Yanagisawa R, Ichinose T, Sadakane K, Yoshino S, Yamaki K, Uchiyama K, Yoshikawa T: Components of diesel exhaust particles differently affect lung expression of cyclooxygenase-2 related to bacterial endotoxin. J Appl Toxicol 24(6), 415-418, 2004.
24. Inoue K, Takano H, Yanagisawa R, Sakurai M, Shimada A, Morita T, Satoh M, Yoshino S, Yoshikawa T, Tohyama C: Protective role of interleukin-6 in coagulatory and hemostatic disturbance induced by lipopolysaccharide in mice.  Thromb Haemost 91(6): 1194-1201, 2004.
25. Inoue K, Takano H, Yanagisawa R, Morita M, Ichinose T, Sadakane K, Yoshino S, Yamaki K, Yoshikawa T: Effect of 15-deoxy-△12, 14-prostaglandin J2 enhances cyclooxygenase-2 expression in the murine lung in the presence of lipopolysaccharide. Arzneim Forsch/DrugRes 54(11): 711-714, 2004.
26. Takano H, Osakabe N, Sanbongi C, Yanagisawa R, Inoue K, Yasuda A, Natsume M, Baba S, Ichiishi E, Yoshikawa T. Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenolic phytochemical, inhibits seasonal allergic rhinoconjunctivitis in humans. Exp Biol Med 229(3): 247-254, 2004.
27. Takano H, Yanagisawa R, Inoue K, Shimada A, Ichinose T, Sadakane K, Yoshino S, Yamaki K, Yoshikawa T:  Nitrogen dioxide air pollution near ambient levels is an atherogenic risk, primarily in obese subjects. Exp Biol Med 229(3): 361-364, 2004.
28. Uchiyama K, Takano H,Yanagisawa R, Inoue K, Naito Y, Yoshida N, Yamaki K, Yoshino S, Murase H, Yoshikawa T: A novel water-soluble vitamin derivative 2-(alpha-D-glucopyranosyl)methyl-2,5,7,8- tetramethylchroman-6-ol, prevents acute lung injury induced by bacterial endotoxin in mice. Clin Exp Pharmacol Physiol 31(4): 226-230, 2004.
29. Sanbongi C,Takano H, Osakabe N, Sasa N, Natsume M,Yanagisawa R, Inoue K, Sadakane K, Ichinose T, Yoshikawa T: Rosmarinic acid in perilla extract inhibits allergic inflammation induced by mite allergen.  Clin Exp Allergy 34(6): 971-977, 2004.
30. InoueK, Takano H, Yanagisawa R, Sakurai M, Shimada A, Sato H,Kato Y, Yoshikawa T: Antioxidative role of urinarytrypsin in hibitor in acute lung injury induced by lipopolysaccharide.  Int J Mol Med 16(6):1029-1033, 2004.
31. Inoue K, Takano H, Yanagisawa R, Sakurai M, Ichinose T, Sadakane K, Yoshikawa T: Effects of nano -particles on antigen-related airway inflammation in mice. Respir Res 6: 106, 2005.
32. Hiyoshi K, Takano H, Inoue K, Ichinose T, Yanagisawa R, Tomura S, Kumagai Y: Effects of phenanthra-quinone on allergic airway inflammation in mice. Clin Exp Allergy 35(9): 1243-1248, 2005.
33. Inoue K, Takano H, Shiga A, Fujita Y, Makino H, Yanagisawa R, Ichinose T, KatoY, Yamada T, Yoshikawa T: Effects of volatile constituents of a rosemary extract on allergic airway inflammation related to house Mite allergen in mice. Int J Mol Med 16(2), 315-319, 2005.
34. Inoue K, Takano H, Yanagisawa R, Ichinose T, Shimada A, Yoshikawa T: Pulmonary exposure to diesel exhaust particles induce airway inflammation and cytokine expression in NC/Nga mice. Arch Toxicol 79(10): 595-599, 2005.
35. Inoue K, Takano H, Yanagisawa R, Ichinose T, Shimada A, Yoshikawa T: Protective role of urinary trypsin inhibitor in acute lung Injury induced by lipopolysaccharide. Exp Biol Med 230(4):281-287, 2005.
36. Inoue K, Takano H, Shimada A, Yanagisawa R, Sakurai M, Yoshino S, Sato H, Yoshikawa T: Urinary trypsin inhibitor protects against systemic inflammation induced by lipopolysaccharide. Mol Pharmacol 67(3): 673-680, 2005.
37. Inoue K, Takano H, Yanagisawa R, Ichinose T, Sadakane K, Yoshino S, Uchiyama K, Yoshikawa T : Effects of 15-deoxy-Δ12, 14-prostaglandin J2 on Toll-like receptor 4 and 2 expression in the murine lung in the presence of lipopolysaccharide.  Clin Exp Pharmacol Physiol 32(3): 230-232, 2005.
38. Inoue K, Takano H, Shimada A, Morita T, Yanagisawa R, Sakurai M, Sato M, Yoshino S, Yoshikawa T: Cytoprotection by interleukin-6 against liver injury induced by lipopolysaccharide. Int J Mol Med 15(2), 221-224, 2005.
39. Inoue K, Takano H, Yanagisawa R, Sakurai M, Ichinose T, Sadakane K, Hiyoshi K, Sato M, Shimada A,Yoshikawa T:  Role of metallothionein in antigen-related airway inflammation. Exp Biol Med 230(1), 75-81, 2005.
40. Hiyoshi K, Takano H, Inoue K, Ichinose T, Yanagisawa R, Tomura S, Cho AK, Froines JR, Kumagai Y: Effects of a single intratracheal administration of phenanthraquinone on murine lung. J Appl Toxicol 25(1):47-51, 2005.
41. Inoue K, Takano H, Yanagisawa R, Sakurai M, Ueki N, Ichinose T, Sadakane K, Yoshino S, Uchiyama K, Yoshikawa T:  Effects of 15-deoxy-△12, 14-prostaglandin J2 on nuclear localization of GATA-3 in the murine lung in the presence of lipopolysaccharide.  ArzneimForsch/DrugRes 55(3): 167-171, 2005.
42. Inoue K, Takano H, ShigaA, Fujita Y Makino H, Yanagisawa R, Kato Y, Yoshikawa T: Effects of volatile constituents of rosemary extract on lung inflammation induced by diesel exhaust particles. Basic Clin Pharmacol Toxicol 99(1): 52-57, 2006.
43. Inoue K, Takano H, Yanagisawa R, Sakurai M, Shimada A, Sato M, Yoshino S, Yoshikawa T: Role of interleukin-6 in fibrinolytic changes induced by lipopolysaccharide in mice. Blood Coagul Fibrinol 17(4):307-309, 2006.
44. Takano H, YanagisawaR, Inoue K, Ichinose T, Sadakane K, Yoshikawa T: Di-(2-ethylhexyl) phthalate enhances atopic dermatitis-like skin lesions in mice. Environ Health Perspect 114(8): 1266-1269, 2006.
45. Inoue K, Takano H, Yanagisawa R, Hirano S, Ichinose T, Shimada A, Yoshikawa T: The role of toll like receptor-4 in airway inflammation induced by diesel exhaust particles. Arch Toxicol 80(5): 275-279, 2006.
46. Yanagisawa R, Takano H, Inoue K, Sakurai M, Ichinose T, Sadakane K Yoshino S, Yamaki K , Yoshikawa T, Hayakawa K: Components of diesel exhaust particles differentially affect Th1/Th2 response in a murine model of allergic airway nflammation. Clin Exp Allergy 36(3): 386-395, 2006.
47. Inoue K, Takano H, Shimada A, Wada E, Yanagisawa R, Sakurai M, Satoh M,Yoshikawa T: Role of metallothionein in coagulatory disturbance and systemic inflammation induced by lipopolysaccharide. FASEB J 20(3): 533-535, 2006.
48. Inoue K, Takano H, Yanagisawa R, Ichinose T, Sakurai M, Yoshikawa T: Effects of nanoparticles on cytokine expression in murine lung in the absence or presence of allergen. Arch Toxicol 80(9): 614-619, 2006.
49. Inoue K, Takano H, Yanagisawa R Hirano S, Sakurai M, Shimada A, Yoshikawa T: Effects of airway exposure to nanoparticles on lung Inflammation induced by bacterial endotoxin in mice. Environ Health Perspect 114(9): 1325-1330, 2006.
50. Inoue K, Takano H, Sakurai M, Oda T, TamuraH, Yanagisawa R, IchinoseT, Shimada A, Yoshino S, Yoshikawa T: Pulmonary exposure to diesel exhaust particles enhances coagulatory disturbance with endothelial damage and systemic inflammation related to lung inflammation. Exp Biol Med 231(10): 1626-1632, 2006.
51. Inoue K, Takano H, Yanagisawa R, Sakurai M, Ueki N, Yoshikawa T: Effects of diesel exhaust on lung inflammation related to bacterial endotoxin in mice. Basic Clin Pharmacol Toxicol 99(5):346-352, 2006.
52. Feng H, Yamaki K, Takano H, Inoue K, Yanagisawa R, Yoshino S: Suppression of Thl and Th2 immune responses in mice by Sinomenine, an alkaloid extracted from the Chinese medical plant Sinomenium acutum. Planta Madia 72(15): 1383-1388, 2006.
53. KaewamatawongT, Shimada A, Okajima M, Inoue H, Morita T, Inoue K, Takano H;Acute and subacute pulmonary toxicity of low dose of ultrafine colloidal silica particles in mice after intratracheal instillation. Toxicol Pathol 34(7): 958-965, 2006.
54. Inoue K, Takano H, Yanagisawa R, Hirano S, Kobayashi T, Ichinose T, Yoshikawa T:Effects of organic chemicals derived from ambient particulate matter on lung inflammation related to lipopolysaccharide. Arch Toxicol 80(12): 833-838, 2006.
55. Inoue K, Takano H, Yanagisawa R, Sakurai M, Shimada A, Morita T, Sato M, Yoshino S, Yoshikawa T: Role of interleukin-6 in toll-like receptor 4 and 2 expressions induced by lipopolysaccharide in the lung. Immunopharmacol Immunotoxicol, 29(1), 63-68, 2006.
56. Tomaru M, Takano H, Inoue K, Yanagisawa R, Osakabe N, Yasuda A, Shimada A, Kato Y, Uematsu H: Pulmonary exposure to diesel exhaust particles enhances fatty changes of the liver in obese diabetic mice. Int J Mol Med 19(1): 17-22, 2007.
57. Inoue K, Takano H, Yanagisawa R, Sakurai M, Ueki N, Yoshikawa T: Effects of diesel exhaust on cytokine production by splenocytes stimulated with lipopolisaccharide. J Appl Toxicol 27(1): 95-100, 2007.
58. Arimoto T, Takano H, Inoue K, Yanagisawa R, Yoshino S, Yamaki K, Yoshikawa T: Pulmonary exposure to diesel exhaust particles on circulatory chemokines during lung inflammation. Int J Immunopathol Pharmacol 20(1): 197-201, 2007.
59. Inoue K, Takano H, Hiyoshi K, Ichinose T, Sadakane K, Yanagisawa R, Tomura S, Kumagai Y: Naphthoquinone enhances antigen-related airway inflammation in mice. Eur Respir J 29(2): 259-267, 2007.
60. Tomaru M, Takano H, Osakabe N, Yasuda A, Inoue K, Yanagisawa R, Ohwatari T, Uematsu H: Dietary supplementation with cacao liquor proanthocyanidines prevents elevation of blood glucose levels in diabetic obese mice. Nutrition 23(4): 351-355, 2007.
61. Inoue K, Takano H, Ichinose T, Tomura S, Yanagisawa R, Sakurai M, Sumi D, Cho AK, Hiyoshi K, Kumagai Y: Effects of naphthoquinone on airway responsiveness in the presence or absence of antigen in mice. Arch Toxicol 81(8): 575-581, 2007.
62. Yanagisawa R, Takano H, Ichinose T, Mizushima K, Nishikawa M, Mori I, Inoue K, Sadakane K, Yoshikawa T: Gene expression analysis of murine lungs following pulmonary exposure to Asian sand gust particles. Exp Biol Med 232(8): 1109-1118, 2007.
63. Inoue K, Takano H, Yanagisawa R, Hirano S, Kobayashi T, Fujitani Y, Shimada A, Ishibashi K, YoshikawaT: Effects of inhaled nanoparticles on acute lung injury induced by lipopolysaccharide in mice. Toxicology 238(2-3): 99-110, 2007.
64. Inoue K, Takano H, Oda T, Yanagisawa R, Tamura H, Ohno N, Adachi Y, Ishibashi K, Yoshikawa T: Candida soluble cell wall β-D-glucan induces lung inflammation in mice. Int J Immunopathol Pharmacol 20(3): 499-508, 2007.
65. Yamaki K, Taneda S, Yanagisawa R, Inoue KI, Takano H, Yoshino S: Enhancement of allergic responses in vivo and in vitro by butylated hydroxytoluene. Toxicol Appl Pharmacol 223(2): 164-172, 2007.
66. Inoue K, Takano H, Yanagisawa R, Sakurai M, Abe S, Yoshino S, Yamaki K, Yoshikawa T: Effects of components derived from diesel exhaust articles on lung physiology related to antigen. Immunopharmacol Immunotoxicol 29(2-3): 403-412, 2007.
67. Feng H, Yamaki K, Takano H, Inoue K, Yanagisawa R, Yoshino S: Effect of sinomenine on collagen-induced in mice. Autoimmunity 40(7), 532-539, 2007.
68. Inoue K, Takano H, Yanagisawa R, Sakurai M, Abe S, Yoshino S, Yamaki K, Yoshikawa T: Effects of nanoparticles on lung physiology in the presence or absence of antigen.Int J Immunopathol Pharmacol 20(4): 737-744, 2007.
69. Huang F, Yamaki K, Tong X, Fu L, Zhang R, Cai Y, Yanagisawa R, Inoue K, Takano H, Yoshino S: Inhibition on the antigen-induced activation of RBL-2HS cells by sinomenine.Int Immunopharmacol 8(3): 502-503, 2008.
70. Koike E, Takano H, Inoue K, Yanagisawa R, Sakurai M, Aoyagi H, Shinohara R, Kobayashi T: Pulmonary exposure to carbon black nanoparticles increases the number of antigen-presenting cells in murine lung. Int J Immunopath Pharmacol 21(1): 35-42, 2008.
71. Saito F, Tasaka S, Inoue K, Miyamoto K, Nakano Y, Ogawa Y, Yamada W, Shiraishi Y, Hasegawa N, Fujishima S, Takano H, Ishizaka A: Role of interleukin-6 in Bleomycin-induced lung inflammatory changes in mice. Am J Respir Cell Mol Biol 38(5): 566-571, 2008.
72. Inoue K, TakanoH, Ohnuki M, Yanagisawa R, Sakurai M, Shimada A, Mizushima K, Yoshikawa T: Size effects of nanomaterials on lung inflammation and coagulatory disturbance. Int J Immunopathol Pharmacol 21(1): 197-206, 2008.
73. Ichinose T, Yoshida S, Sadakane K, Takano H, Yanagisawa R, Inoue K, Nishikawa M, Mori I, Kawazato H, Yasuda A, Shibamoto T: Effects of Asian sand dust, Arizon sand dust, Arizona sand dust amorphous silica and aluminum oxide on allergic inflammation in the murine lung. Inhalation Toxicology 20(7): 685-694, 2008.
74. Inoue K,Takano H, Satoh M: Protective role of metallothionein in coagulatory disturbance accompanied by acute liver injury induced by LPS/D-GalN. Thromb Haemost 99(5): 980-983, 2008.
75. Inoue K, Takano H, Yanagisawa R, Sakurai M, Shimada A, Satoh H, Yoshino S, Yamaki K , Yoshikawa T: Antioxidative role of interleukin 6 in septic lung injury in mice. Int J Immunopathol Pharmacol 21(3), 501-507, 2008.
76. Yasuda A, Takano H, Osakabe N, Sanbongi C, Fukuda K, Natsume N, Yanagisawa R, Inoue K, Kato Y, Osawa T, Yoshikawa R: Cacao liquor proanthocyanidins inhibit lung injury induced by diesel exhaust particles. Int J Immunopathol Pharmacol 21(2): 279-288, 2008.
77. Yanagisawa R, Takano H, Inoue K, Koike E, Sadakane K, Ichinose T: Effects of maternal exposure to di-(2-ethylhexyl) phthalate during fetal and/or neonatal periods on atopic dermatitis in male offspring. Environ Health Perspect 116(9): 1136-1141, 2008.
78. Inoue K, Koike E, Yanagisawa R, Takano H: Impact of diesel exhaust particles on Th2 response in the lung in asthmatic mice. J Clin Biochem Nutr 43: 199-200, 2008.
79. Koike E, Takano H, Inoue K, Yanagisawa R, Kobayashi T: Carbon black nanoparticles promote the maturation and function of mouse bone marrow-derived dendritic cells. Chemosphere 8(3): 502-503, 2008.
80. Inoue K, Takano H, Koike E, Yanagimoto R, Sakurai M, Tasaka S, Ishizaka A, Shimada A: Effects of pulmonary exposure to carbon nanotubes on lung and systemic inflammation with coagulatory disturbance induced by lipopolysaccharide in mice. Exp Biol Med 233(12): 1583-1590, 2008.
81. Koike E, Takano H, Inoue KI, Yanagisawa R: Accelerated differentiation of bone marrow-derived dendritic cells in atopic prone mice. Int Immunopharmacol 8(13-14): 1737-1743, 2008.
82. Inoue K, Takano H, Kaewamatawong T, Shimada A, Suzuki J, Yanagisawa R. Tasaka S, Ishizaka A, Satoh M: Role of metallothionein in lung inflammation induced by ozone exposure in mice. Free Radic Biol Med 45(12): 1714-1722, 2008.
83. Inoue K, Koike E, Yanagisawa R, Takano H: Effect of pulmonary exposure to diesel exhaust particles on extrathoracic CD4 polarization in asthmatic mice. Immunopharmacol Immunotoxicol 31(1): 71-74, 2009.
84. Inoue K, Takano H, Yanagisawa R, Koike E, Shimada A: Size effects of latex nanomaterials on lung inflammation in mice. Toxicol Appl Pharmacol 234(1): 68-76, 2009.
85. Inoue K, Takano H, Oda T, Yanagisawa R, Tamura H, Adachi Y, Ishibashi K, Ohno N: Soluble cell wall β-glucan of Candia induces/enhances apoptosis and oxization stress in murin hung. Immunopharmacol Immunotoxicol 31(1):140-145, 2009.
86. Inoue K, Koike E, Takano H, Yanagisawa R, Ichinose T, Yoshikawa T: Effect of diesel exhaust particles on antigen-presenting cells and antigen-specific Th immunity in mice. Exp Biol Med 234(2): 200-209, 2009.
87. Inoue H, Shimada A, Kaewatawong T, Morita T, Ohta Y, Inoue K, Takano H: Ultrastructural changes of the air-blood-barrier in mice after intratracheal instillation of lipopolysaccharide and ultrafine carbon black particles. Exp Toxicol Pathol 61(4): 51-58, 2009.
88. Takano H, Inoue K, Shimada A, Sato H, Yanagisawa R, Yoshikawa T: Urinary trypsin inhibitor protects against liver injury and coagulatory disturbance induced by lipopolysaccharide/D-galactosamine in mice.  Lab Invest 89(7): 833-839, 2009.
89. Yanagisawa R, Takano H, Inoue K, Koike E, Kamachi T. Sadakane K, Ichinose T: Tinanium dioxide nanoparticles aggravates atopic dermatitis-like skin lesions in NC/Nga mine. Exp Biol Med 234(3): 314-322, 2009.
90. Inoue K, Takano H, Satoh H, Yanagisawa R, Yoshikawa T:Protective role of urinary trypsin inhibitor in lung expression of proinflammatory cytokines accompanied by lethal liver injury in mice. Immunopharmacol Immunotoxicol 31(3): 446-450, 2009.
91. Koike E, Inoue K, Yanagisawa R,Takano H: Di-(2-ethylexyl)phthalate affects immune cells prone mice in vitro. Toxicology 259(1-2): 54-60, 2009.
92. Naota M, Shimada A, Morita T, Inoue K, Takano H: Translocation pathway of the intratracheally instilled C60 fullerenefrom the lung into the blood circulation in mice: possible association of diffusion and caveolae mediated pinocytosis. Toxicol Pathol 27(4): 456-462, 2009.
93. Inoue K, Koike E, Yanagisawa R, Hirano S, Nishikawa M, Takano H: Effect of multi-walled carbon nanotubes on a murine allergic airway inflammation model. Toxicol Appl Pharmacol 237(3):306-316, 2009.
94. Inoue K, Koike E, Yanagisawa R, Adachi Y, Ishibashi K, Ohno N, Takano H: Pulmonary exposure to soluble cell wall β-(1,3)-glucan of Aspergillus induces proinflammatory response in mice. Int J Immunopathol Pharmacol 22(2): 287-297, 2009.
95. Inoue K, Takano H, Koike E, Yanagisawa R, Oda T, Tamura H, Adachi Y, Ohno N: Candida soluble cell wall β-glucan facilities ovalbumin-induced allergic airway inflammation in mice: possible role of antigen-presenting cells. Resp Res 10: 68, 2009.
96. Inoue K, Takano H, Koike E, Warabi E, Yanagawa T, Yanagisawa R, Ishii T: Peroxiredoxin I is a negative regulator Th2-dominant allergic asthma. Int Immunopharmacol 9(11): 1281-1288, 2009.
97. Ichinose T, Hiyoshi K, Yoshida S, Takano H, Inoue K, Nishikawa M, Mori I, Kawazato H, Yasuda A, Shibamoto T: Asian sand dust aggravates allergic rhinitis in guinca pigs induced by Japanese ceder pollen. Inhal Toxicol 21(12): 985-993, 2009.
98. Inoue K, Koike E, Yanagisawa R, Takano H, Sadakane K, Ichinose T: Size effects of polystyrene nanoparticles on atomic dermatitis-like skin lesions in NC/Nga mice. Int J Immunopathol Pharmacol 23(1): 131-141, 2010.
99. Naota M, Mukaiyama T, Shimada A, Yoshida A, Okajima M, Morita T, Inoue K, Takano H: Pathological study of acute pulmonary toxicity induced by intratracheally instilled Asian sand (Kosa). Toxicol Pathol 38(7): 1099-1110, 2010.
100. 100. Inoue K, Koike E, Yanagisawa R, Takano H: Extensive analysis of elastase-induced pulmonary emphysema in rat: ALP in the lung, a new biomarker for disease progression?  J Clin Biochem Nutr 118(2):472-478, 2010.
101. Inoue K, Yanagisawa R, Koike E, Nishikawa M, Takano H: Repeated pulmonary exposure to single-walled carbon nanotubes exacerbates allergic inflammation of the airway: possible role of oxidative stress. Free Radic Biol Med 48(7): 924-934, 2010.
102. Tasaka S, Inoue K, Miyamoto K, Nakano Y, Kamata H, Shinoda H, Hasegawa N, Miyasho T, Satoh M, Takano H: Role of interleukin-6 in elastase-induced lung inflammatory changes in mice. Exp Lung Res 36(6):362-372, 2010.
103. Inoue K, Koike E, Endoh A, Sumi D, Kumagai Y, Hayakawa K, Kiyono M, Tanaka M, Takano H: Diesel exhaust particles induce a Th2 phenotype in mouse naïve mononuclear cells in vitro.  Exp Thr Med 1(1): 761-767, 2010.
104. 104. Yasuda A, Inoue K, Sanbonngi C, Yanagisawa R, Ichinose T, Yoshikawa T, Takano H: Dietary supplementation with fructooligosaccharides airway inflammation related to house dust mite allergen in mice. Int J Immunopathol Pharmacol 23(3): 727-735, 2010.
105. He M, Ichinose T, Yoshida S, Nishikawa M, Mori I, Yanagisawa R, Takano H, Inoue K, Sun G: Urban particulate matter in Beijing, China, enhances allergen-induced murine lung eosinophilia. Inhal Toxicol 22(9):709 -718, 2010.
106. He M, Ichinose T, Yoshida S, Nishikawa M, Mori I, Yanagisawa R, Takano H, Inoue K, Sun G: Airbone Asian sand dust enhances murine lung eosinophilia. Inhal Toxicol 22(12): 1012-1025, 2010.
107. Koike E, Yanagisawa R, Sadakane K, Inoue K, Ichinose T, Takano H: Effects of diisononyl phthalate on atopic dermatitis in vivo and immunologic responses in vitro. Environ Health Perspect 118(4):472-78, 2010.
108. Inoue K, Koike E, Takano H: Comprehensive analysis of elastase-induced pulmonary emphysema in mice; effects of ambient existing particlulate matters. Int Immunopharmacol 10(11): 1380-1389, 2010.
109. Sumi D, Akimori M, Inoue K, Takano H, Kumagai Y: 1,2-Naphthoquinone suppresses lipopolysaccharide-dependent activation of IKKβ/NF-kappaB/NO signaling: an alternative mechanism for the disturbance of inducible catalyzed NO formation.nJ Toxicol Sci 35(6): 891-898, 2010.
110. Kamata H, Tasaka S, Inoue K, Miyamoto K, Nakano Y, Shinoda H, Kimizuka Y, Fujiwara H, Ishii M, Hasegawa N, Takamiya R, Fujishima S, Takano H, Ishizaka A: Carbon black nanoparticles enhance bleomycin-induced lung inflammatory and fibrotic changes in mice. Exp Biol Med 236(3): 315-324, 2011.
111. Inoue K, Yanagisawa R, Koike E, Nakamura R, Ichinose T, Tasaka S, Kiyono M, Takano H: Effects of carbon black nanoparticles on elastase-induced emphysematous lung injury in mice. Basic Clin Pharmacol Toxicol 108(4): 234-240, 2011.
112. Inoue K, Fujitani Y, Kiyono M, Hirano S, Takano H: In vitro effects of nanoparticle-rich diesel exhaust particles on splenic mononuclear cells. Immunopharmacol Immunotoxicol 33(3): 519-524, 2011.
113. Ito T, Inoue K, Nishimura N, Takano H: Phthalate esters modulate the differentiation and maturation of mouse peripheral blood mononuclear cell-derived dendritic cells. J Appl Toxicol. 32(2): 142-148, 2012.
114. Kiyono M, Sone Y, Miyahara K, Oka Y, Nakamura M, Nakamura R, Sato MH, Pan-Hou H, Sakabe K, Inoue K: Genetic expression of bacterial MerC fused plant SNARE in Saccharomyces cerevisiae increased mercury accumulation. Biochem Eng J 56(3), 137-141 2012.
115. Kiyono M, Oka Y, Sone Y, Tanaka M, Nakamura R, Sato M, Pan-Hou H, Sakabe K, Inoue K: Expression of the bacteria heavy metal transporter Merc fused with a plant SNARE, SYP121, in Arabidosis thaliana increases cadmium accumulation and tolerance. Planta Madica 235(4), 841-850, 2012.
116. Nakamura R, Inoue K, Fujitani Y, Kiyono M, Hirano S, Takano H: Effects of nanoparticles on IL-17 production in vitro. J Immunotoxicol 9(1): 72-76, 2012.
117. Nakamura R, Inoue K, Fujitani Y, Kiyono M, Hirano S and Takano H: In vitro study of the effects of nanoparticle-rich diesel exhaust particles on IL-18 production in splenocytes. J Toxicol Sci 36(6): 823-827, 2011.
118. He M, Ichinose T, Yoshida S, Yamamoto S, Inoue K, Takano H, Yanagisawa R, Nishikawa M, Mori I, Sun G, ShibamotoT: Asian sand dust enhances murine lung inflammation caused by Klebsiella pneumonia. Toxicol Appl Pharmacol 258(2): 237-247, 2012.
119. Yasuda A, Inoue K, Sanbonngi C, Yanagisawa R, Ichinose T, Tanaka M, Yoshikawa T, Takano H: Dietary supplementation with fructtooligosaccharides attenuates allergic peritonitis in mice. Biochem Biophys Res Commun. 422(4):546-550, 2012.
120. Yanagisawa R, Warabi E, Inoue KI, Yanagawa T, Koike E, Ichinose T, Takano H, Ishii T: Peroxiredoxin I null mice exhibits reduced acute lung inflammation following ozone exprosure. J Biochem 2012, 152(6): 595-601  
121. Iwasaki T, Yamamoto T, Inoue K, Takaku K : A Case of Lemierr’s Syndrome in association with Liver abscess without any other metastatic lesions. Intern Med 51(11), 1419-1423, 2012.
122. Naota M, Mukaiyama T, Shimada A, Shiotu,S, Kohara Y, Morita T, Inoue K, Takano H: Pathological study of chronic pulmonary toxicity induced by intratracheally instilled Asian sand dust (Kosa). Toxicol Pathol 41(1): 48-62, 2013.
123. Tanaka M, Inoue K, Momoi T, Takano H: In vivo immunoamplifying effects of di-(2-ethylexyl) phthalate on cytokine response. Immunopharmacol Immunotoxicol. 35(1), 147-150, 2013.
124. Tanaka M, Aoki Y, Takano H, Fujitani Y, Hirano S, Nakamura R, Sone Y, Kiyono M, Ichinose T, Itoh T, Inoue K: Effects of exposure to nanoparticles-rich or depleted exhaust on allergic pathophysiology in the murine lung. J Toxicol Sci. 38(1):35-48, 2013.
125. Rattanapinyopituk K, Shimada A, Morita T, Togawa M, Hasegawa T, Seko Y, Inoue K, Takano H:  Ultrastructural changes in the air-blood barrier in mice after intratracheal instillation of Asian sand dust and gold nanoparticles. Exp Toxicol Pathol. (in press)
126. Naota M, Shimada A, Morita T, Yamamoto Y, Inoue K, Takano H: Cavwolae-mediated endocytosis of intratracheally instilled gold colloid nanoparticles at the air-blood barrier in mice. Toxicol Pathol 41(3):487-96, 2013
127. He M, Inoue K, Yoshida S, Tanaka M, Takano H, Sun G, Ichinose T.Effects of airway exposure to di-(2-ethylhexyl) phthalate on allergic rhinitis. Immunopharmacol Immunotoxicol 35(3):390-5, 2013.
128. Sadakane K, Ichinose T, Takano H, Yanagisawa R, Inoue KI, Kawazato H, Yasuda A, Hayakawa K: Organic Chemicals in Diesel Exhaust Particles Enhance Picryl Chloride-Induced Atopic Dermatitis in NC/Nga Mice. Int Arch Allergy Immunol 162(1):7-15, 2013.
129. Sadakane K, Ichinose T, Takano H, Yanagisawa R, Koike E, Inoue KI: The alkylphenols 4-nonylphenol, 4-tert-octylphenol and 4-tert-butylphenol aggravate atopic dermatitis-like skin lesions in NC/Nga mice. J Appl Toxicol (in press)
130. Tanaka M, Takano H, Fujitani Y, Hirono S, Ichinose T, Shimada A, Inoue K: Effects of exposure to nanoparticles-rich diesel exhaust on 8-OHdG synthesis in the mouse asthmatic lung. Experimental and Therapeutic Medicine (in press)
131. Tanaka M, Inoue K, Kitamura Y, Shimada A, Takano H. In vitro action of Sho-seiryu-to on allergen exposed mononuclear cells. Int J Immunopathol Pharmacol 27, 515-518, 2014
132. Inoue K, Tanaka M, Takano H. DEP-induced T(H)17 response in asthmatic subjecs. J Allergy Clin Immunol. 133(5): 1495-1496. 2014.
133. Rattanapinyopituk K, Shimada A, Morita T, Sakurai M, Asano A, Hasegawa T, Inoue K, Takano H. Demonstration of the clathrin-and caveolin-mediated endcytosisi at the maternal-fetal barrier in mouse placenta after intravenous administration of gold nanoparticled.  J Vet Med Sci. 76(3):377-87. 2014.
134. Tanaka M, Inoue K, Takano H: Progress in the study concerning adverse effects of particulate matters on allergy. Jpn J Allergol, 63(10): 1289-1297, 2014.   Honda A, Koike E, Yanagimota R, Inoue K, Takano H: Development of the studies on environmental chemicals and allergy. Jpn J Allergol., 63(9): 1205-1214, 2014.