Education

Biography

Graduated as an MD at Lviv State Medical University (Ukraine) in 1983 with a great passion to become a surgeon in oncology. Thinking that a PhD in experimental oncology would help to realize my dream, I obtained my doctorate at the Institute of Experimental Oncology, National Academy of Sciences of Ukraine in 1987. A fellowship from the International Agency for Research on Cancer (IARC) took me even further from clinical oncology and also from Ukraine. I arrived in London on the first wave of perestroika and began my post-doctoral training in Jim Woodgett's laboratory at the Ludwig Institute for Cancer Research (UCL Branch). Subsequently, I worked in Mike Waterfield's laboratory at the same Institute studying signal transduction via the PI3 kinase pathway. In 1996, I started my own group at the Ludwig Institute for Cancer Research, focusing on the regulation of growth via the S6 kinase pathway. Since 2003, I have been a Professor in the Department of Biochemistry at UCL – now renamed Structural and Molecular Biology, where I have an active research group working on signal transduction and cellular metabolism in health and disease. I have a strong research (113 papers in peer-reviewed journals, H-Index 52) and patent (10 world-wide patents) portfolio and run two drug discovery programs aimed at developing small molecule inhibitors, targeting ribosomal S6 kinase and Aurora A kinase.

Research Interest

Signal transduction, Cancer Biochemistry, Gene expression, Enzyme inhibition

Professional Activities:

• Professor of Cancer Biochemistry, Institute of Structural and Molecular Biology, Division of Biosciences, UCL, 2003-present
• Head, Cell Regulation Laboratory, Ludwig Institute for Cancer Research, UCL Branch, 1996-2003
• Senior Research Scientist, Ludwig Institute for Cancer Research, UCL Branch, 1993-1996
• Postdoctoral Fellow, Ludwig Institute for Cancer Research, UCL Branch, 1989-1993
• International Agency for Research on Cancer (IARC) Fellowship, Ludwig Institute for Cancer Research, UCL Branch, 1988-1989
• Junior Research Scientist, Kavetsky Institute of Oncology, Kyiv, Ukraine, 1987-1988
• PhD student, Kavetsky Institute of Oncology, Kyiv, Ukraine, 1983-1987

Professional societies:

Editorial boardsand Reviews:

Publications

1. Ismail, H. M., Myronova, O., Tsuchiya, Y., Niewiarowski, A., Tsaneva, I., & Gout, I. (2013). Identification of the general transcription factor Yin Yang 1 as a novel and specific binding partner for S6 kinase 2. Cell Signal, 25 (5), 1054-1063. doi:10.1016/j.cellsig.2013.02.002
2. Fenton, T. R., & Gout, I. T. (2011). Functions and regulation of the 70 kDa ribosomal S6 kinases. INT J BIOCHEM CELL B, 43 (1), 47-59. doi:10.1016/j.bioce1.2010.09.018
3. Fenton, T. R., & Gout, I. T. (2011). Functions and regulation of the 70kDa ribosomal S6 kinases. Int J Biochem Cell Biol, 43 (1), 47-59. doi:10.1016/j.biocel.2010.09.018
4. Breus, O., Panasyuk, G., Gout, I. T., Filonenko, V., & Nemazanyy, I. (2010). CoA Synthase is phosphorylated on tyrosines in mammalian cells, interacts with and is dephosphorylated by Shp2PTP. Mol Cell Biochem, 335 (1-2), 195-202. doi:10.1007/s11010-009-0255-6
5. Fenton, T. R., Gwalter, J., Ericsson, J., & Gout, I. T. (2010). Histone acetyltransferases interact with and acetylate p70 ribosomal S6 kinases in vitro and in vivo. Int J Biochem Cell Biol, 42 (2), 359-366. doi:10.1016/j.biocel.2009.11.022
6. Gorbenko, O., Panayotou, G., Zhyvoloup, A., Volkova, D., Gout, I., & Filonenko, V. (2010). Identification of novel PTEN-binding partners: PTEN interaction with fatty acid binding protein FABP4. Mol.Cell Biochem., 337 (1-2), 299-305.
7. Kiyamova, R., Kostianets, O., Malyuchik, S., Filonenko, V., Usenko, V., Gurtovyy, V., . . . Gout, I. (2010). Identification of Tumor-Associated Antigens from Medullary Breast Carcinoma by a Modified SEREX Approach. Mol.Biotechnol..
8. Goh, E. T., Pardo, O. E., Michael, N., Niewiarowski, A., Totty, N., Volkova, D., . . . Gout, I. (2010). Involvement of heterogeneous ribonucleoprotein F in the regulation of cell proliferation via the mammalian target of rapamycin/S6 kinase 2 pathway. J.Biol.Chem., 285 (22), 17065-17076.
9. Gnjatic, S., Cao, Y., Reichelt, U., Yekebas, E. F., Nolker, C., Marx, A. H., . . . Atanackovic, D. (2010). NY-CO-58/KIF2C is overexpressed in a variety of solid tumors and induces frequent T cell responses in patients with colorectal cancer. Int.J.Cancer, 127 (2), 381-393.
10. Fenton, T. R., Gwalter, J., Cramer, R., & Gout, I. T. (2010). S6K1 is acetylated at lysine 516 in response to growth factor stimulation. Biochem Biophys Res Commun, 398 (3), 400-405. doi:10.1016/j.bbrc.2010.06.081