Director, Center for Innovations in Wound Healing Research
School of Medicine
- 1974 (BA, Biology) State University of New York at Buffalo, USA
- 1978 (PhD, Cell Biology) The Tulane University, New Orleans, LA, USA
- 1978-1981 (Post Doc) Department of Cell Biology and Anatomy, School of Medicine, The Johns Hopkins University, USA
Ira M. Herman, Ph.D. is tenured professor and director, Center for Innovations in Wound Healing Research, Tufts University School of Medicine. Dr. Herman holds appointments in the departments of developmental, molecular and chemical biology; ophthalmology and biomedical engineering. Professor Herman is founding member and director emeritus, Integrated Studies Program, and is currently director, Cell Molecular and Developmental Biology Program, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, where he has received the Distinguished Faculty Award. Throughout his professional career, and since the time of his graduate and post-graduate studies at Tulane University, Harvard University and Johns Hopkins University School of Medicine, professor Herman’s research interests have been focused on revealing the mechanisms controlling cellular and tissue responses to injury and tissue regeneration, including the vascular remodeling and angiogenesis controlling wound healing. These basic studies have given rise to several fundamental insights and a deepened understanding of many physiologic and pathologic processes, including the molecular mechanisms regulating cell migration, cytokinesis and tissue morphogenesis. Furthermore, these discoveries have fostered the development of novel technologies for therapeutics and device development that have been described in several issued and pending US and international patents, some of which focus on the promotion of wound healing, scar-less healing, inhibition of ocular or tumor-induced angiogenesis, the etiology of essential hypertension and the abrogation of cancer cell invasion. During his three-decade tenure at Tufts University, professor Herman has published scores of scholarly reviews and book chapters, and over sixty primary research papers appearing in high-impact, peer-reviewed scientific journals. He serves as editor and scientific reviewer for many scientific journals and is regularly invited as a speaker at scientific meetings, worldwide. Fulfilling his commitment to the scientific community, Professor Herman continues to serve as scientific reviewer and expert consultant for pharma and the biotechnology sectors while having chaired and continuing to participate on grant advisory panels in the USA and abroad.
Our discovery and innovation programs continue to be focused on revealing key insights and molecular mechanisms that govern cellular shape, motility and mechanics, which are required and/or instrumental to normal developmental processes, which include but are not confined to: (i) the folding of the embryo, (ii) the creation and differentiation of the body’s organ systems, (iii) tissue remodeling during repair, (iv) recapitulation of developmental programs integral to pathogenesis and human disease processes. Because of our basic interests in understanding these molecular and cellular mechanisms control mechanims, we continue to find ourselves at the intersection of developmental and regenerative biology while aiming to innovate advanced molecular and cellular medicines for ‘next generation’ therapeutics and ‘smart’ devices. To these ends, we seek to understand the molecular mechanisms underlying the migratory and proliferative responses to injury and wound healing, the remodeling of the vasculature during physiologic and pathologic angiogenesis, and the cytoskeletal-specific adaptive responses during host-pathogen interactions. Our basic studies continue to be translated into several biomedically-relevant arenas, including our creation of vascularized tissue and organ constructs for regenerative medicine, developing innovative cellular medicines able to abrogate or inhibit pathologic angiogenesis during aging (wet age-related macular degeneration), diabetes (diabetic retinopathy) and cancer (tumor-angiogenesis) as well as creating non-antibiotics based cellular therapies capable of abrogating microbial pathogenesis.
|1975-1978||Graduate Teaching Assistant||Department of Biology Tulane University New Orleans, LA, USA|
|1978-1981||Postdoctoral Fellow||Department of Cell Biology and Anatomy School of Medicine Johns Hopkins University Baltimore, MD|
|1979-1981||Instructor of Cell, Tissue and Organ Biology||Department of Cell Biology and Anatomy School of Medicine The Johns Hopkins University Baltimore, MD|
|1981-1988||Assistant Professor|| Department of Anatomy and Cell Biology School of Medicine Tufts University
|1988-1993||Associate Professor (Tenure)|| Department of Anatomy and Cell Biology, School of Medicine, Tufts University
|1993-1995||Associate Professor (Tenure)||Department of Physiology, School of Medicine, Tufts University, Boston, MA|
|1995-2013||Professor of Molecular Physiology and Pharmacology|| Department of Physiology
School of Medicine, Tufts University, Boston, MA
|1995-2013||Professor of Anatomy and Cellular Biology||Tufts University School of Medicine Boston, MA|
|1996-Present||Professor of Ophthalmology||School of Medicine Tufts University Tufts Medical Center, Boston, MA|
|2013-Present|| Professor of Integrative Physiology and Pathobiology
Professor of Developmental, Molecular and Chemical Biology
|School of Medicine Tufts University Tufts Medical Center, Boston, MA|
|1997-2002||Director, GRASP CENTER|| Image Analysis Core
Tufts Medical Center
|2005||Director and Founding Member|| Integrated Studies Program
Sackler School of Graduate Biomedical Sciences School of Medicine Tufts University Boston MA
|2006||Chairman, Faculty Senate Co-team leader, Cardiovascular Medicine Strategic Initiative|| School of Medicine
|2006||Director, Tufts Center for Innovations in Wound Healing Co-Director, Tufts Vision Science Center|| School of Medicine
|2008||Professor of Biomedical Engineering||Tufts University, Medford, MA|
|2010||Director, Cellular and Molecular Physiology Program||Sackler School of Graduate Biomedical Sciences School of Medicine Tufts University Boston, MA|
|2012||Professor, Cell Biology||University of Maine Maine Medical Center Portland, ME|
|2013||Faculty Advisor, Graduate Student Council||Sackler School of Graduate Biomedical Sciences School of Medicine Tufts University Boston, MA|
|2014|| Professor, Integrative hysiology and Pathobiology
Professor, Developmental, Molecular and Chemical Biology
Director, Cellular, Dolecular and Developmental Biology Program,
|Sackler School Graduate Biomedical Sciences School of Medicine Tufts University Boston, MA|
|1975-1978||Graduate research assistant||upper level courses in Physiology, Cell Biology, Microbiology, Invertebrate Zoology|
|1978-1981||Instructor||Histology (Cells and Tissues, Organ Histology, School of Medicine, The Johns Hopkins Medical School)|
|1981-1990||Lecturer||Medical Histology, Tufts University|
|1981-1993||Lecturer||Veterinary Histology, Tufts University|
|1981-1993||Lecturer||Dental Histology, Tufts University|
|1982-present||Lecturer||Molecular Cell Biology, Tufts University|
|1985-present||Coordinator, Graduate Journal Club||CMDB Program, Tufts University|
|1988-1993||Course Director, Histology||Tufts University|
|1992-1993||Coordinator MD/PhD Journal||Tufts University|
|1994-present||Lecturer||Developmental Biology, Tufts University|
|1994-present||Discussion Group Leader||Pathobiology, Tufts University|
|1998-present||Lecturer||Veterinary Histology, Tufts University|
|2000-present||Facilitator CMDB Program Journal Club||Tufts University|
|2003-present||Lecturer, Medical Physiology||TUSM, MBS|
|2004-2005||Coordinator, ISP Journal Club||Tufts University|
|2007-present||Mentor, M.S. in Biomedical Sciences||Tufts University|
|2008-present||Faculty Advisor Curie House||TUSM|
|2012-present||Course Director, Pathobiology||TUSM|
|2015-present||Molecular & Cellular Medicine Track Leader CMDB Program||Sackler School of Graduate Biomedical Sciences|
- Herman, I.M. and Pollard, T.D. 1978. Actin localization in fixed dividing cells stained with fluorescent heavy meromyosin. Exp Cell Res 114:15-25.
- Herman, I.M. and Pollard, T.D. 1979. Comparison of purified anti-actin and fluorescent-heavy meromyosin staining patterns in dividing cells. J Cell Biol 80:509-520.
- Herman, I.M. and Pollard, T.D. Electron microscopic localization of cytoplasmic myosin with ferritin-labeled antibodies. 1981. J Cell Biol 88:345-351.
- Herman, I.M. Crisona, N. and Pollard, T.D. 1981. Relation between cell activity and the distribution of cytoplasmic actin and myosin. J Cell Biol 90:84-91.
- Wong, A., Pollard, T.D. and Herman, I.M. 1983. Actin filament stress fibers in vascular endothelial cells in vivo. Science 219:867-869.
- Herman, I.M. and D'Amore, P.A. 1984. Capillary endothelial chemotaxis: Loss of stress fibers in response to retina-derived growth factor. J Muscle Res Cell Motility, 5:697-704.
- Young, W.C. and Herman, I.M. 1985. Extracellular matrix modulation of endothelial cell shape and motility following injury in vitro. J. Cell Sci. 73:19-32.
- Herman, I.M. and D'Amore, P.A. 1985. In vitro and in situ characterization of the vascular pericyte: Discrimination from smooth muscle and endothelium. J Cell Biol. 101:43-52.
- Herman, I.M. 1987. Extracellular - cytoskeletal signaling in vascular cells. Tissue and Cell 19:1-19.
- Herman, I.M., Brandt, A.M., Warty, V.S., Klein, E.C., Teodori, M.F. and Borovetz, H.S. 1987. Hemodynamics and the vascular endothelial cytoskeleton. J. Cell Biol. 105:291-302.
- Herman, I.M. and Castellot, J.J. 1987. Regulation of smooth muscle cell growth by endothelial-synthesized extracellular matrices. Arteriosclerosis 7:463-469.
- Jester, J.V., Rodriguez, M. and Herman, I.M. 1987. Characterization of the vascular corneal wound-healing fibroblast: new insight into the myofibroblast. Am. J. Pathol. 127:140-148,
- Herman, I.M., Newcomb, P.M., Coughlin, J.E. and Jacobson, S. 1987. Characterization of microvascular cell cultures from normotensive and hypertensive rat brains: pericyte-endothelial cell interactions in vitro. Tissue and Cell 19:197-206,
- Herman, I.M. and Jacobson, S. 1988. In situ analysis of microvascular pericytes in hypertensive rat brains. Tissue and Cell. 20:1-12.
- Brandt, A.M., Shah, S.J., Rogers, V.G.J., Hoffmeister, J., Teodori, M.F., Herman, I.M., Kormos, R.L. and Borovetz, H.S. Biomechanics of the artery wall under simulated flow. J. Biomech 21:107-113, 1988.
- Yost, J.C. and Herman, I.M. 1988. Age-related and region-specific adaptations of the arterial endothelial cytoskeleton during atherogenesis. Am. J. Pathol. 130:595-604.
- Askey, D.B. and Herman, I.M. 1988. Computer-assisted analysis of the vascular endothelial cell migratory response to injury in vitro. Comp. Biomed. Res. 21:551-561.
- DeNofrio, D., Hoock, T.C. and Herman, I.M. 1988. Functional sorting of actin isoforms in microvascular pericytes. J. Cell Biol. 109:191-202.
- Conrad, P., Nederlof, M.A., Herman, I.M. and Taylor, D.L. 1989. Correlated distribution of actin, myosin and microtubules at the leading edge of migrating swiss 3T3 cells. Cell Motil. Cytoskel. 14:1-17.
- Morel, N.M.L., Dodge, A., Patton, W.F., Herman, I.M., Hechtman, H.B. and Shepro, D. 1989. Pulmonary microvascular endothelial cell contractility on silicone rubber substrate. J. Cell Physiol. 141:633-659.
- Warty, V.J., Calvo, W.J., Berceli, S.A., Pham, S.M., Durham, S.J., Tanksale, S.K., Klein, E.C., Herman, I.M. and Borovetz, H.S. 1989. Hemodynamics alters LDL metabolism. J. Vascular Surgery 10:392-400,
- Neumann, S.J., Sevick, E.M., Lincoff, A.M., Warty, V.S., Brandt, A.M., Berceli, S.A., Herman, I.M. and Borovetz, H.S. 1990. Experimental determination and mathematical model of the transient incorporation of cholesterol in the arterial wall. J. Exp. Math. 52:711-732.
- Yost, J.C. and Herman, I.M. 1990. Substratum-induced stress fiber assembly in vascular endothelial cell during spreading in vitro. J. Cell Sci. 95:507-520.
- Herman, I.M. 1990. Endothelial cell matrices modulate smooth muscle growth and contractile phenotype. Haemostasis 20:166-177.
- Berceli, S.A., Borovetz, H.S., Sheppeck, R.A., Moosa, H.H, Warty, V.J., Armany, M.A. and Herman, I.M. 1991. Mechanism of vein graft atherosclerosis: LDL metabolism and cytoskeletal actin reorganization. J. Vascular Surgery 13:336-347, (Liebig Foundation Award).
- Hoock, T.C., Newcomb, P.M. and Herman, I.M. 1991. ßactin and its mRNA are localized at the plasma membrane and regions of moving cytoplasm during the cellular response to injury. J. Cell Biology 112:653-664, (Cover photo).
- Garana, R.M.R, Herman, I.M., Barry, P., Cavanagh, H.D., Jester, J.V. 1991. Confocal evaluation of the 3-D cytoskeletal protein organization in cat keratocytes. Invest. Ophthal. Vis. Sci. 32: 1143-47.
- Marguez-Sterling, N., Herman, I.M., Pesacreta, T., Arai, H., Terres, G., and Forgac, M. 1991. Immunolocalization of the vacuolar type proton ATPase from clathrin coated vesicles. Eur. J. Cell Biol. 56: 19-33.
- Healy, A.M. and Herman, I.M. Localization of fluorescent basic fibroblast growth factor in living retinal endothelial cells. 1992. Exp. Eye Res. 55: 663-69.
- Healy, A.M. and Herman, I.M. 1992. Density-dependent accumulation of basic fibroblast growth factor in the subendothelial extracellular matrix. Eur. J. Cell Biol. 59: 56-67.
- Newcomb, P.M. and Herman, I.M. 1993. Pericyte actin mRNA: modulation by matrix and comparison with aortic smooth muscle. J Cell Physiol 155: 385-93.
- Garana, R.M.R., Petroll, M., Chen, W-T., Herman, I.M., Barry, P., Andrews, P., Cavahaugh, H.D. and Jester, J.V. 1993. Radial keratotomy: II. Role of the myofibroblast in corneal wound healing. Inv. Ophthal. Vis. Sci. 67: 442-98.
- Bostrom, K., Watson, K.E., Horn, S., Wortham, C., Herman, I.M. and Demer, L.L. 1994. Bone morphogenetic protein expression in human atherosclerotic lesions. J Clin Invest. 91: 1800-1809.
- Kostyk, S.K., D'Amore, P.A., Herman, I.M., Wagner, J.A. 1994. Optic nerve injury alters basic fibroblast growth factor localization in the retina and optic tract. J. Neurosci. 14: 1441-49.
- Shuster, C.B. and Herman, I.M. 1995. Indirect association of ezrin and F-actin:isoform specificity and calcium-sensitivity. J Cell Biol. 128: 837-48.
- Herman, I.M. 1996. Stimulation of human keratinocyte migration and proliferation in vitro: insights into the cellular responses to injury and wound healing. Wounds. 8: 33-48.
- Shuster, C.B. and Herman, I.M. 1996. Betacap73: a novel beta actin-specific capping protein that regulates forward protrusion formation during cell motility. Cell Motil and Cytoskeleton 35:175-87.
- Allen, P.G., C. B. Shuster, J. Kas, C. Chaponnier, P.A. Janmey and Herman, I.M. 1996. Phalloidin binding and rheological differences amongst actin isoforms. Biochemistry 35: 14062-69.
- Bassel, G, Zhang, H.L., Byrd, A.L., Femino, A.M., Singer, R.H., Taneja, K.L., Lifshitz, L.M., Herman, I.M. And Kosik, K.S. 1998. Sorting of beta actin mRNA and protein in differentiating neurons in culture: Implications for targeting cytoskeletal proteins to growth cones. J Neuroscience 18: 251-65,
- Potter, D.A., J.S. Tirnauer, R. Janssen, D.E. Croall, C.N. Hughes, J.M. Mier, M. Maki and Herman, I.M. 1998. Calpain regulates actin remodeling during cell spreading. J Cell Biology 141: 647-62.
- Micheva, K.D., A. Vallee, C. Beaulieu, I.M. Herman and Leclerc N. 1998. Beta actin is confined to structures having high capacity of remodelling in developing and adult rat cerebellum. Eur J Neurosci 10:3785-98.
- Croce K., Flaumenhaft R., Rivers M., Furie B, Furie B.C., Herman I.M., Potter D.A. 2000. Inhibition of calpain blocks platelet secretion, aggregation, and spreading. J Biol Chem. 274: 36321-7.
- Helmbold, P., Nayak, R.C., Marsch, W., and Herman, I.M. Characterization of clonal human dermal microvascular pericytes. Microvascular Research 61: 160-166, 2001.
- Papetti, M.P. and Herman, I.M. 2001. Controlling vascular endothelial and tumor-derived cell growth: role of the 4F2 cell surface antigen. Am J. Pathol 159: 165-177.
- Welch, A.Y. and Herman, I.M. 2002. Cloning and characterization of bcap73: a novel regulator of b-actin assembly. Int J Biochem & Cell Biol. 34: 864-81.
- Diefenbach TJ, Latham VM, Yimlamai D, Liu CA, Herman, I.M., Jay DG. 2002. Myosin 1c and myosin IIB serve opposing roles in lamellipodial dynamics of the neuronal growth cone. J Cell Biol. 158:1207-17.
- Potter, D, Srirangam, A, Fiacco, K, Brocks, D, Hawes, J, Herndon, C, Maki, M, Acheson, D, and Herman, I.M. 2003. Calpain regulates enterocyte brush border actin assembly and pathogenic E. coli-mediated effacement. J Biol Chem. 278:30403-12, 2003.
- Riley, K, Tellier, P and Herman, I.M. 2003. bcap73-Arf6 interactions modulate endothelial shape and motility after injury in vitro. Mol Biol Cell 14: 4155-61.
- Kolyada, A, Riley, K and Herman, I.M. 2003. Rho GTPase regulates cell shape and contractile phenotype in an isoactin-specific manner. Am J Physiol 285:1116-21.
- Sieczkiewicz, GS and Herman, I.M. 2003. TGFb-1 regulates pericyte growth and contractile phenotype. Microvascular Research, 66: 190-6.
- Papetti, M, Shujath, JM, Riley, K, Herman, I.M. 2003. Molecular mechanisms regulating microvascular morphogenesis: control of retinal pericyte growth and differentiation. Investigative Ophthalmology and Visual Sciences, Invest. Ophthal. Visual Sci. 44: 4994-5005.
- Herman, I.M. 2004. Collagenase accelerates human keratinocyte responses to injury and wound healing. Wounds 16: 1-5.
- Riley, K.N. and Herman, I.M. 2005. Collagenase promotes the cellular responses to injury and wound healing in vivo. J Burns & Wounds: 4:141-59.
- Kutcher ME, Kolyada AY, Surks HK, Herman I.M. 2007. Pericyte Rho GTPase Mediates Both Pericyte Contractile Phenotype and Capillary Endothelial Growth State. Am J Pathol. 171:693-701. (August, 2007, American Journal of Pathology, Cover Photo.)
- Demidova-Rice, T.N., Salomatina, E.V., Yaroslavsky, A.N., Herman, I.M., and M.R. Hamblin. 2007. Low-level light stimulates excisional wound healing in mice. Lasers in Surgery and Medicine 39: 706-15.
- Wang, X., Zhang, X., Castellot, J., Herman, I.M. Iafrati, M., and D.L. Kaplan. 2008. Controlled Release from Multilayer Silk Biomaterial Coatings to Modulate Vascular Cell Responses. Biomaterials 29:894-903.
- Ritchie, J.M., Brady, M.J., Riley, K.N., Ho, T.D., Campellone, K.G., Herman, I.M., Donohue-Rolfe, A., Waldor, M.K., and Leong, J.L. 2007. EspFu, a type III-translocated effector of actin assembly, fosters epithelial association and late-stage intestinal colonization by E. coli O157:H7. Cellular Microbiology (ePub ahead of print).
- Krautz-Peterson, G. Chapman-Bonofiglio, S. Boisvert, K., Feng, H., Herman, I.M., Tzipori, S., Sheoran, A.S. 2008. Intracellular neutralization of Shiga toxin 2 by an A subunit-specific human monoclonal antibody. Infect. Immun 76: 1931-9.
- Alt-Holland, A., Shamis, Y., Riley, K.N., DesRochers, T.M., Fusenig, N.E., Herman, I.M. and J.A. Garlick. 2008. E-cadherin suppression directs cytoskeletal rearrangement and intraepithelial tumor cell migration in 3D human skin equivalents. J Invest Dermatol. 128: 2498-507.
- Jennifer T. Durham, Ira M. Herman Durham, J.T. and Herman, I.M. 2009. Inhibition of angiogenesis in vitro: A central role for β-actin dependent- cytoskeletal remodeling. Microvascular Research (ePub ahead of print).
- Lee, S., Zeiger, A., Maloney, J., Maciej K., Van Vliet K., and Herman, I.M. 2010. Pericyte actomyosin-mediated contractionat the cell–material interface can modulate the microvascular niche. J. Physics Condensed Matter 22: 1-11.
- Borenstein, J.T., Megley, K., Wall, K., Pritchard, E. M., Truong, D., Kaplan, D.L. Tao, S. L. and Herman, I.M. 2010. Tissue Equivalents Based on Cell-Seeded Biodegradable Microfluidic Constructs. Materials 3(3), 1833-1844.
- Rajagopal S, Ji Y, Xu K, Li Y, Wicks K, Liu J, Wong KW, Herman IM, Isberg RR, Buchsbaum RJ. 2010. Scaffold proteins IRSp53 and spinophilin regulate localized Rac activation by T-lymphocyte invasion and metastasis protein 1 (TIAM1). J Biol Chem. Apr 1. [Epub ahead of print]
- Kotecki, MK., Zeiger, AS, Van Vliet, K and Herman, IM. 2010. Calpain- and talin-dependent control of microvascular pericyte contractility and cellular stiffness. Microvasc Res. 80 (3): 339-48. PMID: 20709086 [PubMed - in process]
- Demidova-Rice, T, A Geevarghese and Herman, IM. 2010. Bioactive peptides derived from vascular endothelial cell extracellular matrices promote microvascular morphogenesis and wound healing in vitro. Wound Repair Regen. Dec 6. doi: 10.1111/j.1524-475X.2010.00642.x. [Epub ahead of print] PMID: 21134032.
- Boscolo, E, Stewart, CL, Greenberger, S, Wu, JK, Durham, JT, Herman IM, Mulliken JB, Kitajewski J, Bischoff J. 2011. JAGGED1 Signaling Regulates Hemangioma Stem Cell-to-Pericyte/Vascular Smooth Muscle Cell Differentiation. Arterioscler Thromb Vasc Biol. 2011 Oct;31(10):2181-92. Epub 2011 Jul 14.
- Lai, Y-S , Riley, K , Cai A, Leong, JM, Herman, IM. 2011. Calpain mediates epithelial cell microvillar effacement by enterohemorrhagic Escherichia coli. Frontiers in Microbiology 2: 1- 9. Doi: 3389/fmicb.2011.00222. Pub Med Central in process.
- Kuchay SM, Wieschhaus AJ, Marinkovic M, Herman, IM, Chishti AH. 2012. Targeted gene inactivation reveals a functional role of calpain-1 in platelet spreading. J Thromb Haemost. 10:1120-32. doi: 10.1111/j.1538 7836.2012.04715.x. PMID: 22458296 [PubMed - in process]
- Yamada KH, Kozlowski DA, Seidl SE, Lance S, Wieschhaus AJ, Sundivakkam P, Tiruppathi C, Chishti I, Herman, IM, Kuchay SM, Chishti AH. 2012. Targeted gene inactivation of calpain-1 suppresses cortical degeneration due to traumatic brain injury and neuronal apoptosis induced by oxidative stress. J Biol Chem. 287: 13182-93. Epub 2012 Feb 24. PMID: 22367208 [PubMed - indexed for MEDLINE]
- Demidova-Rice TN, Wolf L, Deckenback J, Hamblin MR, Herman, IM. 2012. Human platelet-rich plasma- and extracellular matrix-derived peptides promote impaired cutaneous wound healing in vivo. PLoS One.;7:e32146. Epub 2012 Feb 23. PMID: 22384158 [PubMed - indexed for MEDLINE]
- Mendel TA, Clabough EB, Kao DS, Demidova-Rice TN, Durham JT, Zotter BC, Seaman SA, Cronk SM, Rakoczy EP, Katz AJ, Herman IM, Peirce SM, Yates PA. 2013. Pericytes derived from adipose-derived stem cells protect against retinal vasculopathy. PLoS One. May 31;8(5):e65691. doi: 10.1371/journal.pone.0065691. Print 2013. PMID: 23741506
- Mendel TA, Clabough EB, Kao DS, Demidova-Rice TN, Durham JT, Zotter BC, Seaman SA, Cronk SM, Rakoczy EP, Katz AJ, Herman IM, Peirce SM, Yates PA. 2013. Correction: Pericytes Derived from Adipose-Derived Stem Cells Protect against Retinal Vasculopathy. PLoS One. Sep 17;8(9). doi: 10.1371/annotation/679017bf-abd5-44ce-9e20-5e7af1cd3468. eCollection 2013
- Durham, JT, Surks, HK, Dulmovits, BM and Herman, IM. 2014. Pericyte contractility controls endothelial cell cycle progression and sprouting: insights into the mechanics of the angiogenic switch. August 20, 2014). doi:10.1152/ajpcell.00185.2014. Recognized as AJP Paper of the Year-2014
- Chetty A, Bennett M, Dang L, Nakamura D, Cao GJ, Mujahid S, Volpe M, Herman IM, Becerra SP, Nielsen HC. 2014. Pigment Epithelium-derived Factor Mediates Impaired Lung Vascular Development in Neonatal Hyperoxia. Am J Respir Cell Mol Biol. Jul 23. [Epub ahead of print] PMID: 25054647
- Cronk, SM, Mendel, T, Hoehn, H KH, Ray, C, Bruce, A, Guendel, AM, Herman, IM, Peirce, SM, and Yates, PA. 2014. Adipose-derived stem cells from diabetic sources show impaired vascular stabilization in an animal model of diabetes-induced retinal dysfunction. Stem Cells Translational Medicine. Mar 13. pii: sctm.2014-0108. [Pubmed Abstract]
- Durham, JT, Dulmovits, BM, Sheets, AS and Herman, IM. 2015. Pericyte chemomechanics and the angiogenic switch: Insights into the pathogenesis of proliferative diabetic retinopathy. IOVS. 56: 3441-59. PMID. 26030100.
- Zeiger, A, Durham, JT, VanVliet, KVV, Herman, IM. 2015. Static mechanical strain induces capillary endothelial cell cycle re-entry and sprouting. Submitted to Integrative Biology.
Chapters in books and invited reviews
- Herman, I.M., Pollard, T.D. and Wong, A.J. "Contractile Proteins in Endothelial Cells" in Conference on Endothelium. Annals of the N.Y. Academy Sciences, 401:50-60. NY Academy Sciences Publishing Co., New York, N.Y, 1982.
- Pollard T.D., Aebi, U., Cooper, J.A., Elzinga, M., Fowler, W.E., Griffith, L.M. Herman, I.M., Heuser, J., Isenberg, G., Kiehart, D.P., Levy, J., MacLean-Fletcher, S., Maupin, P., Mooseker, M.S., Runge, M., Smith, P.R. and Tseng, P. "The mechanism of actin filament assembly and cross-linking". In: Cell and Muscle Motility, 2:15-43. Plenum Pub. Corp, 1982.
- Pollard, T.D., Griffith, L. and Herman, I.M. "Actin filament-microtubule interactions". In: Differentiation and Function of Hematol. Cells. New York: A.R. Liss Publishing, Inc. pp. 183-192, 1982.
- Herman, I.M. "Extracellular - cytoskeletal signalling: Regulation of the vascular endothelial migratory response to injury." In: Occlusive Vascular Disease. Atherosclerosis Reviews. Raven Press, N.Y, 1987.
- D`Amore, P.A., Orlidge, L. and Herman, I.M. "Regulation of retinal microvascular growth" in Progress in Retinal Research, N. Osborne and G. Chader, eds. Permagon Press, N.Y, 1987.
- Herman, I.M. Developing probes and markers for biochemical and morphological analysis of cytoskeletal elements in vascular cells. CRC Crit. Rev. Anat. Sci. 1:133-148, 1988.
- Herman, I.M., Warty, V.S. and Borovetz, H.S. "Hemodynamics and vascular cytoskeletal biology" in Atherosclerosis VIII. Excepta Medica Scientifica. Elsevier 425-429, 1989.
- Herman, I.M. "Vascular endothelial cell-synthesized extracellular matrices as attachment substrates in vitro." in Cell Culture Techniques in Cardiovascular Research. H.M. Piper, ed. Spinger Verlag Publishing Co., 1990.
- Herman, I.M. "Actin isoform diversity and function" in Current Opinion in Cell Biology 5: 48-56 (T.D. Pollard and R.D. Goldman, eds). Current Biology, LTD. 1993.
- Herman, I.M. "Microvascular pericytes in development and disease" in Molecular mechanisms regulating blood-brain barrier function. (W. Pardridge, ed). Raven Press, NY,1993.
- Herman, I.M. Molecular mechanisms regulating the vascular endothelial cell motile response to injury. J. Cardiovascular Pharm. 22 (4): S25-S36, 1993.
- Herman, I.M. Controlling the expression of smooth muscle contractile protein isoforms: A role for extracellular matrix? Am. J. Resp. Cell Mol. Biol. 9: 3-4, 1993.
- Herman, I.M. Molecular biology of the cell: end of the road or new horizons to be explored? Quarterly Rev Biol. 71: 403-4, 1996.
- Shuster, C.B. and Herman, I.M. Mechanics of vascular cell motility. Microcirculation 5: 239-257, 1998.
- Herman, I.M. and Shujath, J.M. Human keratinocyte wound healing: a role for collagenase and matrix-binding growth factors. Springer Verlag, Germany 1999
- Nayak R.C. and Herman, I.M. "Microvascular Pericytes: Isolation, Propagation and Identification". In: Methods in Molecular Medicine - Angiogenesis: Reviews and Protocols. Murray C (Ed.), The Humana Press Inc., Totowa, New Jersey. Volume 46, Chapter 18, pp. 247-264. 2001
- D'Amore, P.A. and Herman, I.M. "Molecular and Cellular Control of Angiogenesis", in The Liver, 3rd ed., I.M. Arias, ed, Plenum University Press, Inc. 2001.
- Papetti, M and Herman, I.M. "Molecular mechanisms of normal and tumor-derived angiogenesis" Am J Physiol: Cell Physiology, 282: 947-70, 2002.
- Herman, I.M. “ Regulation of microvascular morphogenesis” Encyclopedia of the Microvasculature, D. Shepro, ed. Elsevier Pub, Inc. NY. 2006.
- Herman, I.M. “ARF6: the regulator of actin dynamics and cap73 function”, Methods in Enzymology 404, W. Balch, C. Der, A. Hall, eds. 2006.
- Herman, I.M. and A. Leung. Development of a 3-D model system for studying the angiogenesis of wound healing, in ‘Angiogenesis Protocols II’: Methods in Molecular Biology and Medicine, Stewart Martin, ed. 2008, Humana Press, Inc.
- Kutcher, M.E. and Herman, I.M. 2009. The pericyte: Cellular regulator of microvascular blood flow. Microvascular Research 77: 235-46 (ePub ahead of print).
- Herman, I.M. ‘Retinal Pericytes: A Look Forward’ in Encyclopedia of the Eye D’Amore, P. ed, Elsevier Press, Oxford UK. (2010, Invited Review). vol. 3, pp. 296-299.
- Nussenbaum, F. and Herman, I.M. 2010. Tumor Angiogenesis: Insights and Innovations. Journal of Oncology. 2010 (2010), Article ID 132641, 24 pages
- Schultz, GS., Davidson, J., Kirsner, R., Bornstein, P. and Herman, I.M. 2011. Dynamic Reciprocity in the Wound Microenvironment. Wound Repair Regen. (Mar-Apr;19(2):134-48. doi: 10.1111/j.1524-475X.2011.00673.x. Review. PMID:21362080 [PubMed - indexed for MEDLINE].
- Tucker, BA, St Geneiz, M, Herman, IM, Tao, S, Borenstein, J, D’Amore, PA and Young, MJ. 2010. Tissue engineering for the treatment of age-related macular degeneration. Expert Rev. Ophthalmology 5: 587-590 (doi:10.1586/eop.10.56)
- Durham JT, Herman I.M. 2011. Microvascular modifications in diabetic retinopathy. Curr Diab Rep. 11:253-64. PMID: 21611764 [PubMed - in process].
- Willard, A. and Herman, I.M. 2011. Vascular Complications and Diabetes - Current Therapies and Future Challenges. J Ophthalmology 209538. doi: 10.1155/2012/209538. Epub 2012 Jan 9. PMID:22272370 [PubMed].
- Demidova-Rice TN, Hamblin MR, Herman IM. 2012. Acute and impaired wound healing: pathophysiology and current methods for drug delivery, part 1: normal and chronic wounds: biology, causes, and approaches to care. Adv Skin Wound Care. 25:304-14. PMID: 22713781 [PubMed - in process]
- Demidova-Rice TN, Hamblin MR, Herman IM. 2012. Acute and impaired wound healing: pathophysiology and current methods for drug delivery, part 2: role of growth factors in normal and pathological wound healing: therapeutic potential and methods of delivery. Adv Skin Wound Care. Aug;25:349-70. PMID: 22820962 [PubMed - in process]
- Dulmovits BM, Herman IM. 2012. Microvascular remodeling and wound healing: A role for pericytes. Int J Biochem Cell Biol. 44: 1800-12. doi: 10.1016/j.biocel.2012.06.031. Epub Jun 28. PMID: 22750474 [PubMed - in process]
- Anita Geevarghese, Herman, IM. 2014. Pericyte-Endothelial Cross-Talk: Implications and Opportunities for Advanced Cellular Therapies. Translational Research. Jan 24. pii: S1931-5244(14)00012-7. doi: 10.1016/j.trsl.2014.01.011.
- Herman, I.M. 2014. "Dynamic reciprocity and wound healing", in Schultz, G. (ed.), Wound Healing: The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at http://hstalks.com/?t=BL1863792-Herman)
- Sheets, A.R., Hwang, C.K., Herman, IM. 2015. “Developing ‘smart’ point-of- care diagnostic tools for ‘next generation’ wound care” in Translating Regenerative Medicine to the Clinic, P. Baptista and A. Attala, ed. Elsevier Publishing Co. Inc.