Education

Biography

Dr.Xie is currently a Research Assistant Professor in the Center for Drug Designat the University of Minnesota. He obtained a PhD degree in Pharmaceutical Sciences from South Dakota State University in 2014. He then joined the Center for Drug Design at the University of Minnesota as a Research Associate, and was promoted to Research Assistant Professor in 2016. Dr. Xieleads and manages the Bioanalytical and Pharmacokinetics Laboratory in the Center for Drug Design. His research has focused on LC/MS/MS bioanalysis, preclinical pharmacokinetics and in vitro ADME in drug discovery and development.

Research Interest

Bio analytical method development and validation; In Vitro ADME; In Vivo PK

Scientific Activities

Honors

• Rho Chi Honor Society (2010)

Journal Reviewer

• Clinical and Experimental Pharmacology and Physiology
• Molecular and Cellular Biochemistry
• International Journal of Oncology
• Molecular Medicine Reports
• International Journal of Molecular Medicine
• Oncotarget
• Experimental and Therapeutic Medicine
• Oncology Reports

Editorial Board

• Bioequivalence & Bioavailability International Journal (BEBA)

RESEARCH SUPPORT

Ongoing Research Support

1R01AI121315-01A1, NIH (2016/06/14-2021/05/31)
PIs: Sarafianos, Stefan; Wang, Zhengqiang
Title: Taking aim at HBV eradication using novel NRTIs and Capsid effectors.
(This project focuses on the development of leads that target viral replication by capsid assembly effectors (CAEs) and highly potent novel NRTIs.)
Role: Co-Investigator

Publications

1. Xie J, Ding C, Ge Q, Zhou Z, Zhi X. Simultaneous determination of ginkgolides A, B, C and bilobalide in plasma by LC-MS/MS and its application to the pharmacokinetic study of Ginkgo Biloba extract in rats. J Chromatogr B. 2008; 864: 87–94.
2.  Xie J, Ge Q. Matrix effects in bioanalysis by LC/MS. Chin J Pharm Anal. 2008; 28(8): 1386-1389.
3.  Xie J, Potter A, Xie W, Lynch C, Seefeldt T. Evaluation of a dithiocarbamate derivative as a model of thiol oxidative stress in H9c2 rat cardiomyocytes. Free Radic Biol Med. 2014; 70: 214-222.
4. Muthyala, R.; Shin, W. S.; Xie, J.; Sham, Y. Y. Discovery of 1-hydroxypyridine-2-thiones as selective histone deacetylase inhibitors and their potential application for treating leukemia. Bioorg. Med. Chem. Lett. 2015; 25: 4320-4324.
5.  Ai T, Qiu L, Xie J, Geraghty R, Chen L. Design and Synthesis of an Activity-based Protein Profiling Probe Based on Cinnamic Hydroxamic Acid. Bioorg. Med. Chem. 2016; 24(4):686-692。
6.  Ai T, Wilson D, More S, Xie J, Chen L. 5-((3-Amidobenzyl)oxy)nicotinamides as Sirtuin 2 Inhibitors. J. Med. Chem. 2016; 59(7):2928-2941. Curriculum Vitae: Jiashu Xie, Ph.D. 3
7.  Rawson JM, Daly MB, Xie J, Clouser CL, Landman SR, Reilly CS, Bonnac L, Kim B, Patterson SE, Mansky LM. 5-Azacytidine enhances the mutagenesis of HIV-1 by reduction to 5-aza-2'- deoxycytidine. Antimicrob. Agents Chemother. 2016; 60(4):2318-25.
8.  Daly MB, Roth ME, Bonnac L, Maldonado JO, Xie J, Clouser CL, Patterson SE, Kim B, Mansky LM. Dual anti-HIV mechanism of clofarabine. Retrovirology. 2016; 13:20.
9. Rawson JM, Roth ME, Xie J, Daly MB, Clouser CL, Landman SR, Reilly CS, Bonnac L, Kim B, Patterson SE, Mansky LM. Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase. Bioorg Med Chem. 2016; 24(11):2410-2422.
10. Wu B, Tang J, Wilson DJ, Huber AD, Casey MC, Ji J, Kankanala J, Xie J, Sarafianos SG, Wang Z. 3-Hydroxypyrimidine-2,4-dione-5-N-benzylcarboxamides potently inhibit HIV-1 integrase and RNase H. J Med Chem. 2016; 59(13):6136-6148.
11. Sadhu S, Xie J, Zhang H, Perumal O, Guan X. Glutathione disulfide liposomes – a research tool for the study of glutathione disulfide associated functions and dysfunctions. Biochem Biophys Rep. 2016; 7: 225-229.
12. Ding R, Zhang T, Xie J, Williams J, Ye Y, Chen L. Eeyarestatin I derivatives with improved aqueous solubility. Bioorg Med Chem Lett. 2016; 26(21):5177-5181.
13.  Ai T, Willett R, Williams J, Ding R, Wilson D, Xie J, Kim DH, Puertollano R, Chen L. N-(1-Benzyl- 3,5-dimethyl-1H-pyrazol-4-yl)benzamides: Antiproliferative Activity and Effects on mTORC1 and Autophagy. ACS Med Chem Lett. 2016; 8(1):90-95.
14. Zhou W, Wang Y, Xie J, Geraghty R. A Fluorescence-Based High-Throughput Assay to Identify Inhibitors of Tyrosylprotein Sulfotransferase Activity. Biochem Biophys Res Commun. 2017; 482(4):1207-1212.
15. Sadhu S, Wang S, Dachineni R, Averineni RK, Seefeldt T, Xie J, Tummala H, Bhat GJ, Guan X. In vitro and in vivo anti-metastatic effect of glutathione disulfide liposomes. Cancer Growth Metastasis. 2017; 10: 1-11.