esin-aki-yalcin
Esin Aki Yalcin, Ph.D
Professor of Pharmaceutical Chemistry

Department of Faculty of Pharmacy, Ankara University,
Ankara, Turkey
Phone: +90-532-3373111
E-mail: [email protected]

Education

1993 Professor Degree, Pharmaceutical Chemistry Dept., Faculty of Pharmacy, Ankara University.   TURKEY
1987 Assoc. Prof. Degree, Pharmaceutical Chemistry Dept., Faculty of Pharmacy, Ankara University. TURKEY
1986 Assist. Prof. Degree, Pharmaceutical Chemistry Dept., Faculty of Pharmacy, Ankara University. TURKEY
1983 Ph. D. (Pharmaceutical Chemistry) Faculty of Pharmacy, Ankara University TURKEY

Biography

Research Interest

  • Synthesis and rational drug design studies on chemotherapeutical active novel heterocyclic compounds
  • Computational Drug Design Methods
  • Quantitative Structure-Activity Relationships
  • Molecular Modeling Techniques

Scientific Activities

Honors

Chair of Organization Committee of International Meetings

  1. 15th European Symposium on Quantitative Structure-Activity Relationships”, Istanbul, Turkey,05-10 September 2004.
  2. 6th AFMC Medicinal Chemistry Symposium, Istanbul, Turkey, 08-11 July 2007.
  3. 5th International Symposium on Computational Methods in Toxicology and Pharmacology Integrating Internet Resources”, 04-08 July 2009, Istanbul, Turkey.
  4. Workshop on Computer Aided Drug Design & Development, 02-05 Feb 2007, Istanbul, Turkey.
  5. Workshop on Computer Aided Drug Design & Development-Molecular Modeling, 26-29 June 2008Ankara, Turkey.
Awards
  1. International Scientific Partnership Foundation Medal “Badge of Honor"
  2. International Scientific Partnership Foundation Honourable Diploma of ISPF.
  3. “Asian Federation of Medicinal Chemistry” Lifetime Fellowship Diploma.

Publications

SCI - SCI Expanded Journals
  1. YALCIN, I., SENER, E., OZDEN, T., OZDEN, S., AKIN, A., Synthesis and Microbiological Activity of 5-Metyl-2-(p-substituted-phenyl) benzoxazoles, European Journal of Medicinal Chemistry, 25, 705-708 (1990).
  2. SENER. E., YALCIN, I., SUNGUR, E., QSAR of Some Antifungal Benzoxazoles and Oxazolo (4,5-b)pyridines Against C. albicans, Quantitative Structure-Activity Relationships, 10, 223-228 (1991).
  3. YALCIN, I., OREN, I., SENER, E., AKIN, A., UCARTURK, N., The Synthesis and the Structure- Activity Relationships of Some Substituted Benzoxazoles, Oxazolo(4,5-b)pyridines, Benzothiazoles and Benzimidazoles as Antimicrobial Agents, European Journal of Medicinal Chemistry, 27, 401-406 (1992).
  4. YALCIN, I., SENER, E., QSARs of Some Novel Antibacterial Benzimidazoles, Benzoxazoles and Oxazolopyridines against an Enteric Gram-negative Rod, International Journal of Pharmaceutics, 98, 1-8 (1993).
  5. SENER, E., TURGUT,H., YALCIN, I., OREN, I., TURKER, L., CELEBI, N., AKIN, A., Structure-Activity Relationships of Some Antimicrobial 5-Substituted-2-(3-pyridyl)benzoxazoles Using Quantum Chemical Calculations, International Journal of Pharmaceutics, 110, 109-115 (1994).
  6. SENER, E., YALCIN, I., TEMIZ, O., OREN, I., AKIN, A. and UCARTURK, N.  “Synthesis and Structure-Activity Relationships of Some 2,5-Disubstitured Benzoxazoles and Benzimidazoles as Antimicrobial Agents”, Il Farmaco, 52(2), 99-103 (1997).
  7. OREN, I., TEMIZ, O., YALCIN, I., SENER, E., AKIN, A., UCARTURK, N. “Synthesis and Microbiological Activity of 5(or 6)-Methyl-2-substituted Benzoxazole and Benzimidazole Derivatives”, Arzneim-Forsch./Drug Res., 47(12), 1393-1397 (1997).
  8. YALCIN, I., KAYMAKCIOGLU, B. K., OREN, I., SENER, E., TEMIZ, O., AKIN, A., ALTANLAR, N., “Synthesis and Microbiological Activity of Some Novel N-(2-Hydroxyl-5-substitutedphenyl)benzacetamides, Phenoxyacetamides and Thiophenoxyacetamides as The Possible Metabolites of Antimicrobial Active Benzoxazoles”, Il Farmaco, 52(11), 685-689 (1997).
  9. TEMIZ, O., OREN, I., SENER, E., YALCIN, I.,  UCARTURK, N., “Synthesis and Microbiological Activity of Some Novel 5- or 6-Methyl-2-(2,4-disubstituted phenyl)benzoxazole Derivatives”, Il Farmaco, 53, 337-341 (1998).
  10. OREN, I., TEMIZ, O., YALCIN, I., SENER, E., ALTANLAR, N., “Synthesis and Antimicrobial Activity of Some Novel 2, 5- and/or 6-Substituted Benzoxazole and Benzimidazole Derivatives”, European Journal of Pharmaceutical Sciences, 7, 153-160 (1998).
  11. MROZEK, A., KAROLAK-WOICIECHOWSKA, J., YALCIN, I., SENER, E., “Crystal Structure of 2-(2-Cyclohexyl) ethyl benzimidazole”, Z. Kristallogr. NCS, 214, 181-182 (1999).
  12. MROZEK, A., TRZEZWINSKA, H., KAROLAK-WOICIECHOWSKA, J., YALCIN I., SENER, E., “Molecular Structure of 5-Chloro-2-(p-t-butylphenyl)benzoxazole. Relation Between Structure and Antimicrobial Activity of 2,5-Disubstituted Benzoxazoles”, Polish J. Chem., 73, 625-633 (1999).
  13. AKI-SENER, E., ARPACI-TEMIZ, O., YALCIN, I., ALTANLAR, N.; “Synthesis and microbiological activity of some novel 5-benzamido- and 5-phenylacetamido- substituted 2-phenylbenzoxazole derivatives” Il Farmaco, 55, 397-405 (2000) .
  14. YALCIN, I., OREN, I., TEMIZ, O., AKI-SENER, E., “QSARs of some novel isosteric heterocyclics with antifungal activity” Acta Biochimica Polonica, 47 (2), 481-486 (2000).
  15. AKI-Sener, E., BIngOl, K.K., Oren, I., TemIz-Arpacı, O., YalCın, I., Altanlar, N.: “Synthesis and microbiological activity of some N-(o-hydroxyphenylbenzmides and phenylacetamides as the possible metabolites of antimicrobial active benzoxazoles, Part II.”, Il Farmaco, 55, 469-476 (2000).
  16. R. CzylkowskI, J. Karolak-WojcIechowska, YALCIN, I., AKI-SENER, E., “Structure and Conformational Preferences of 2-Substituted-benzoxazoles”, J. Mol. Structure, 598(2-3), 197-205, 2001
  17. AKI-SENER, E., BINGOL, K.K., TEMIZ-ARPACI, O., YALCIN, I., ALTANLAR, N, “Synthesis and microbiological activity of some N-(2-hydroxy-4-substitutedphenyl)benzamides, phenylacetamides and furamides as the possible metabolites of antimicrobial active benzoxazoles”, Il Farmaco, 57, 451-456, (2002).
  18. TEMIZ-ARPACI, O., AKI-SENER, E., YALCIN, I., ALTANLAR, N., “Synthesis and microbiological activity of some novel N-[2-(p-substitutedphenyl)-5-benzoxazolyl]-cyclohexyl carboxamide, -cyclohexyl acetamide and –cyclohexyl propionamide derivatives”, Il Farmaco, 57, 771-775, (2002).
  19. TEMİZ-ARPACI, Ö., AKI-ŞENER E., YALÇIN, İ., ALTANLAR, N., “Synthesis and Antimicrobial Activity of Some 2-(p-substituted-phenyl)benzoxazol-5-yl-arylcarboxamides”, Arch. Pharm. Pharm. Med. Chem, 6, 283-288, (2002).
  20. AKBAY, A., OREN, I., TEMIZ-ARPACI, O., AKI-SENER, E., YALCIN, I., “Synthesis and HIV-1 Reverse Transcriptase Inhibitor Activity of Some 2,5,6-Substituted Benzoxazole, Benzimidazole, Benzothiazole and Oxazolo(4,5-b)pyridine Derivatives”, Arzneim-Forsch./Drug Res., 53 (4), 266-271, (2003).
  21. YALCIN, I., TEKINER; B. P., OREN-YILDIZ, I., TEMIZ-ARPACI, O., AKI-SENER, E., ALTANLAR, N., “Synthesis and Antimicrobial Activity of Some Novel 2,6,7-trisubstituted-2H-3,4-dihydro-1,4-benzoxazin-3-one Derivatives”, Indian Journal of Chemistry, 42B, 905-909, (2003).
  22. ALPER, S., TEMIZ-ARPACI, O., AKI-SENER, E., YALCIN, I.,”Some New bi-and ter-benzimidazole Derivatives as Topoisomerase I Inhibitors”, Il Farmaco, 58, 497-507, (2003).
  23. YILDIZ-OREN, I., AKI-SENER, E., ERTAS, C., TEMIZ-ARPACI, O., YALCIN, I., ALTANLAR, N., “Synthesis and Microbiological activity of Some Substituted N-(2-hydroxy-4-nitrophenyl)benzamides, henylacetamides as Possible Metabolites of Antimicrobial Active Benzoxazoles”, Turk J Chem., 28, 441-449, (2004).
  24. PINAR, A., YURDAKUL, P., YILDIZ, I., TEMIZ-ARPACI, O., ACAN, N.L., AKI-SENER, E., YALCIN, İ.,”Some Fused Heterocyclic Compounds as Eukaryotic Topoisomerase II Inhibitors”, Biochemical and Biophysical Research Communications, 317, 670-674, (2004).
  25. OREN-YILDIZ, I., YALCIN, I., AKI-SENER E., ALTANLAR, N., “Synthesis and Structure-Activity Relationships of New Antimicrobial Active Multisubstituted Benzoxazole Derivatives”, European Journal of Medicinal Chemistry, 39, 291-298, (2004).
  26. PLEMPER, R.K., ERLANDSON, K.J., LAKDAWALA, A.S., SUN, A., PRUSSIA, A., BOONSOMBAT, J., AKI-SENER E., YALÇIN, I., YILDIZ, I., TEMIZ-ARPACI, O., TEKINER; B. P., LIOTTA, D.,  SNYDER, J.P., COMPANS, R.W., “A Target Site for Template-Based Design of Measles Virus Entry Inhibitors”, PNAS, 101(15), 5628-5633, (2004).
  27. OREN-YILDIZ, I., TEKINER-GULBAS,  B. P., YALCIN, I., TEMIZ-ARPACI, O., AKI-SENER E., ALTANLAR, N., “Synthesis and Antimicrobial Activity of New 2-[p-Substituted-benzyl]-5-[substituted-carbonylamino]benzoxazoles”, Arch. Pharm. Pharm. Med. Chem, 337,  402-410, (2004).
  28. TEMIZ-ARPACI, O., OZDEMIR, A., YALCIN, I., YILDIZ, I., AKI-SENER, E.,ALTANLAR, N., “Synthesis and Antimicrobial Activity of Some 5-[2-(Morpholin-4-yl)acetamido] and/or 5-[2-(4-Substituted piperazin-1-yl)acetamido]-2-(p-substituted phenyl)benzoxazoles”Arch. Pharm. Chem. Life Sci. 338, 105-111 (2005).
  29. TEMIZ-ARPACI, O., TEKINER-GULBAS, B., YILDIZ, I., AKI-SENER, E., YALCIN, I., “3D-QSAR analysis on benzazole derivatives as eukaryotic topoisomerase II inhibitors by using comparative molecular field analysis method”  Bioorganic and Medicinal Chemistry, 13, 6354-6359, 2005.
  30. TEMIZ-ARPACI, O., OZDEMIR, A., YALCIN, I., YILDIZ, I., AKI-SENER, E., ALTANLAR, N., “Synthesis and Antimicrobial Activity of Some 5-[2-(Morpholin-4-yl)acetamido] and/or 5-[2-(4-Substituted piperazin-1-yl)acetamido]-2-(p-substituted phenyl)benzoxazoles,  Arch. Pharm. Chem. Life Sci., 338, 105-111, (2005).
  31. TEMIZ-ARPACI, O, TEKINER-GULBAS, B., YILDIZ, I., AKI-SENER, E.,YALCIN, I., “3D-QSAR analysis on benzazole derivatives as eukaryotic topoisomerase II inhibitors by using comparative molecular .field analysis method” Bioorganic & Medicinal Chemistry, (2005), 13, 6354–6359.
  32. VARGA, A., AKI-SENER, E., YALCIN, I., TEMIZ-ARPACI, O., TEKINER-GULBAS, B., CHEREPNEV, G., MOLNAR, J., “Induction of Apoptosis and Necrosis by Resistance Benzazoles and Benzoxazines on Tumour Cell Line Mouse Lymphoma L5718 Mdr+cells” In vivo, 19, 1087-1092, (2005).
  33. LAGE, H., TEKINER-GULBAS, B., TEMIZ-ARPACI, O., AKI-SENER, E.,YALCIN, I., “High antineoplastic activity of heterocyclic DNA topoisomerase II inhibitors in cancer cells with resistance against classical DNA topoisomerase II-targeting drugs and structure-activity relationships”, Int. J. Cancer., 119, 213-220, 2006.
  34. TEKINER-GULBAS, B., TEMIZ-ARPACI, O., YILDIZ, I., AKI-SENER, E.,YALCIN, I., “3-D-QSAR Study on Heterocyclic Topoisomerase II Inhibitors Using CoMSIA”, SAR and QSAR in Enviromental Research, 17(2), 1-12, 2006.
  35. TEMIZ-ARPACI, O., COBAN, T., TEKINER-GULBAS, B., CAN-EKE, B., YILDIZ, İ., AKI-SENER, E., YALCIN, I., ISCAN, M., “A Study on the Antioxidant Activties of Some New Benzazole Derivatives”, Acta Biol. Hungarica, 57 (2), 201-209, 2006.
  36. ALPER-HAYTA, S., AKI-SENER, E., TEKINER-GULBAS, B., YILDIZ, İ., TEMIZ-ARPACI, O., YALCIN, I., ALTANLAR, N., “Synthesis, Antimicrobial Activity and QSARs of New Benzoxazine-3-ones”, Eur. J. Med. Chem., 41, 1398-1404, 2006.
  37. TEKINER-GULBAS, B., TEMIZ-ARPACI, O., YILDIZ, I., AKI-SENER, E.,YALCIN, I., “3D-QSAR Study on Heterocyclic Topoisomerase II Inhibitors using CoMSIA”, SAR and QSAR in Enviromental Research, 17(2), 121-132, (2006). 
  38. ERTAN, T., YILDIZ, I., OZKAN, S., TEMIZ-ARPACI, O., KAYNAK, F., YALCIN, I., AKI-SENER, E., ABBASOGLU, U., "Synthesis and Biological Evaluation of New n-(2-Hydroxy-4(or 5)-nitro/ aminophenyl)benzamides and Phenylacetamides as Antimicrobial Agents", Bioorganic and Medicinal Chemistry, 15, 2032-2044, (2007).
  39. KAROLAK-WOJCIECHOWSKA, J., MROZEK, A., CZYLKOWSKI, R., TEKINER-GULBAS, B., AKI-SENER, E., YALCIN, I., "Five-membered heterocycles. Part IV: Impact of heteroatom on benzazole aromaticity", Journal of Molecular Structure, 839, 125-131, (2007).
  40. OKSUZOGLU, E., TEMIZ-ARPACI, O., TEKINER-GULBAS, B., EROGLU, H., SEN, G., ALPER, S., YILDIZ, I., DIRIL, N., AKI-SENER, E., YALCIN, I., "A Study on the Genotoxic Activities of Some New Benzoxazoles", Medicinal Chemistry Research, 16, 1–14, (2007)
  41. OKSUZOGLU, E., TEKINER-GULBAS, B., ALPER, S., TEMIZ-ARPACI, O., ERTAN, T., YILDIZ, I., DIRIL, N., SENER-AKI, E., YALCIN, I., "Some Benzoxazoles and Benzimidazoles as DNA Topoisomerase I and II Inhibitors", Journal of Enzyme Inhibition and Medicinal Chemistry, 23, 37-42, (2007).
  42. TEKINER-GULBAS, B., TEMIZ-ARPACI, O., OKSUZOGLU, E., EROGLU, H., YILDIZ, I., DIRIL, N., AKI-SENER, E., YALCIN, I., "QSAR of Genotoxic Active Benzazoles", SAR and QSAR in Environmental Research, 18, 251–263, (2007).
  43. MARTINS, M., SCHELZ, Z., MARTINS, A., MOLNAR, J., HAJÖS, G., RIEDL, Z., VIVEIROS, M., YALCIN, I., AKI-SENER, E., AMARAL, L., "In Vitro and Ex Vivo Activity of Thioridazine Derivatives against Mycobacterium tuberculosis", International Journal of Antimicrobial Agents, 29, 338–340, (2007).
  44. YILDIZ, I., ERTAN, T., BOLELLI, K., TEMIZ-ARPACI, O.,YALCIN, I. AKI, E., "QSAR and Pharmacophore Analysis on Amides against Drug-Resistant S. aureus", SAR and QSAR in Environmental Research, 19, 101-113, (2008).
  45.  ARISOY, M., TEMIZ-ARPACI, O., YILDIZ, I., KAYNAK-ONURDAG, F., AKI, E., YALCIN, I., ABBASOGLU, U., "Synthesis, Antimicrobial Activity and QSAR Studies of 2,5-Disubstituted Benzoxazoles", SAR and QSAR in Environmental Research, 19:5, 589-612, (2008).
  46.  TEKINER-GULBAS, B., FILAK, L., VASKO, G.A., EGYED, O., YALÇIN, I., AKI-SENER, E., RIEDL, Z., HAJOS, G., "Synthesis of Novel Pyrazolo[5,1-b][1,3]benzothiazoles: a New Pericyclic Pathway", Heterocycles, 75, 2005-2012, (2008).
  47.  TEMIZ-ARPACI, O.,YILDIZ, I., ÖZKAN, S., KAYNAK, F., AKI-ŞENER, E., YALÇIN, I., "Synthesis and Biological Activity of Some New Benzoxazoles", European Journal of Medicinal Chemistry, 43, 1423-1431, (2008).
  48. ALPER-HAYTA, S., ARISOY, M., TEMIZ-ARPACI, Ö., YILDIZ, I., AKI, E., ÖZKAN, S., KAYNAK, F., "Synthesis, Antimicrobial Activity, Pharmacophore Analysis of Some New 2-(Substitutedphenyl/ benzyl)-5-[(2-benzofuryl)carboxamido]benzoxazoles", European Journal of Medicinal Chemistry, 43, 2568-2578, (2008).
  49. FILAK, L., TEKINER-GULBAS,B., RIEDL, Z., VASKÓ, G.A., EGYED,O., YALÇIN, I., AKI, E., HAJÓS, G., “Ring Expansion of N-Aminobenzothiazolium Salts to Benzothiazines and Benzothiadiazines” Acta Chim. Slov., 56, 622–628, (2009).
  50. ERTAN, T., YILDIZ, I., TEKINER-GULBAS, B., BOLELLI, K., TEMIZ-ARPACI, O., OZKAN, S., KAYNAK, F., YALCIN, I., AKI, E., “Synthesis, biological evaluation and 2D-QSAR analysis of benzoxazoles as antimicrobial agents”, European Journal of Medicinal Chemistry, 44, 501–510, (2009).
  51. ZEYBEK, B., DURMUS, Z., TEKINER-GULBAS, B., AKI-SENER, E., YALCIN, I., KILIC, E., “Electrochemical Behaviors and Determinations of Some 2,5-Disubstituted Benzoxazole Compoumds at the HAnging Mercury Drop Electrode”, Current Pharm. Analysis, 5, 21-27, (2009).
  52. AKI, E., YALCIN, I., YILDIZ, I., TEMIZ-ARPACI, O., BOLELLI, K., ERTAN-BOLELLI, T., “DNA-Topoisomerase Inhibitory Activity of Some Heterocyclic Compounds and Their Structure-Activity Relationships”, Medicinal Chemistry Research, 19 (Suppl. 1),  S6, 2010.
  53. YALCIN, I., AKI, E., YILDIZ, O., TEMIZ-ARPACI, O., “Antimicrobial Activity and Structure-Activity Relationships of Some Synthesized Benzazoles and Their Possible Metabolites”, Medicinal Chemistry Research, 19 (Suppl. 1), S41, 2010.
  54. TASKIN, T., YILMAZ, S., YILDIZ, I. YALCIN, I., AKI, E., “Insight into eukaryotic topoisomerase II-inhibiting fused heterocyclic compounds in human cancer cell lines by molecular docking” SAR and QSAR in Environmental Research ,. 23( 3–4), 345–355 (2012).
  55. BOLELLI, K., YALCIN, I., ERTAN-BOLELLI, T., ÖZGEN, S., KAYNAK-ONURDAG, F., YILDIZ, I., AKI, E.” Synthesis of novel 2-[4-(4-substituttedbenzamido/phenylacetamido)phenyl] benzothiazoles as antimicrobial agents” Med. Chem. Res. 21:3818–3825 (2012).
  56. YILMAZ, S., YALCIN, I., KAYNAK-ONURDAG, F., OZGEN, S., YILDIZ, I., AKI, E., Synthesis And In Vitro Antimicrobial Activity Of Novel 2-(4-(Substituted Carboxamido) Benzyl/Phenyl)Benzothiazoles, Croatica Chemica Acta, 86(2), 223-231, 2013.
  57. YILMAZ, S., YALCIN, I., KAYNAK-ONURDAG, F., OZGEN, S., YILDIZ, I., AKI, E., Synthesis and In vitro Antimicrobial Activity of Novel 2-(4-(Substituted-carboxamido) benzyl / phenyl)benzothiazoles, Croatica Chemical Acta, 86(2), 223-231, 2013.
  58. BHAGYASREE, J.B., VARGHESE, H.T., PANICKER, C.Y., SAMUEL, J., VAN ALSENOY, C., , YILDIZ, I., AKI, E, Vibrational spectroscopic (FT-IR, FT-Raman, 1H NMR and UV) investigations and computationaBOLELLI, K.l study of 5-nitro-2-(4-nitrobenzyl) benzoxazole Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy 102, 99-113, 2013.
  59. BHAGYASREE, J.B., VARGHESE, H.T.,YOHANNAN PANICKER, C., SAMUEL, J., VAN ALSENOY, C., YILMAZ, S., YILDIZ, I., AKI, E. Quantum mechanical and spectroscopic (FT-IR, FT-Raman, 1H NMR and UV) investigations of 2-(p-nitrobenzyl) benzoxazole , Journal of Molecular Structure 1046 , 92-100, 2013.
  60. KAPLAN-OZEN, C., TEKINER-GULBAS, B., FOTO, E., YILDIZ, I., DIRIL, N., AKI, E., YALCIN, I., "Benzothiazole derivatives as human DNA topoizomerase IIα inhibitors", Med. Chem. Res., 22(12), 5798-5808, (2013). 
  61. AKI-YALCIN, E., ERTAN-BOLELLI, T., TASKIN-TOK, T., OZTURK, O., ATAEI, S., OZEN, C., YILDIZ, I., YALCIN, I., "Evaluation of Inhibitory Effects of Benzothiazole and 3-Amino-benzothiazolium Derivatives on DNA Topoisomerase II by Molecular Modeling Studies", SAR and QSAR in Environmental Research, 25(8), 637-649, (2014). doi:10.1080/1062936X.2014.923039.
  62. ERTAN-BOLELLI, T., MUSDAL, Y., BOLELLI, K., YILMAZ, S., AKSOY, Y., YILDIZ, I., AKI-YALCIN, E., YALCIN, I., “Synthesis, Biological Evaluation of 2-Substituted-5-(4-nitrophenylsulfonamido) benzoxazoles as Human GST P1-1 Inhibitors and Description of the Binding Site Features”, ChemMedChem,9(5), 984-992, (2014). doi:10.1002/cmdc.201400010.
  63. YILMAZ, S., ALTINKANAT-GELMEZ, G., BOLELLI, K., GUNESER-MERDAN, D., OVER-HASDEMIR, M. U., YILDIZ, I., AKI-YALCIN, E., YALCIN, I., “Pharmacophore Generation of 2-Substituted Benzothiazoles as AdeABC Efflux Pump Inhibitors in A. baumannii”, SAR and QSAR in Environmental Research, 25(7), 551-563, (2014). doi:10.1080/1062936X.2014.919357 .
  64. ZILIFDAR, F., ALPER-HAYTA, S., YILMAZ, S., KAPLAN-OZEN, C., FOTO, E., AYDOGAN, Z., YILDIZ, I., AKI, E., YALCIN, I., DIRIL, N., "Genotoxic potentials and eukaryotic DNA topoisomerase I inhibitory effects of some benzoxazine derivatives", Med. Chem. Res., 23(1), 480-486, (2014). 
  65. SERAP YILMAZ, GULSEN ALTINKANAT-GELMEZ, KAYHAN BOLELLI, DENIZ GUNESER-MERDAN, M. UFUK OVER-HASDEMIR, ESIN AKI-YALCIN, ISMAIL YALCIN, "Binding Site Feature Description of 2-Substituted Benzothiazoles as AcrAB-TolC Efflux Pump Inhibitors in E. coli", SAR and QSAR in Environmental Research, 1-25 (2015). DOI:10.1080/1062936X.2015.1106581.
  66. ANDRY NUR HIDAYAT, ESIN AKI-YALCIN, MERAL BEKSAC, ERMING TIAN, SAAD Z. USMANI, TUGBA ERTAN-BOLELLI, ISMAIL YALCIN, "Insight into Human Protease Activated Receptor-1 as Anticancer Target by Molecular Modeling", SAR and QSAR in Environmental Research, 1-23 (2015). DOI:10.1080/1062936X.2015.1095799.
  67. TUGBA ERTAN-BOLELLİ, KAYHAN BOLELLİ, SUZAN OKTEN, FATMA KAYNAK-ONURDAG, ESİN AKİ-YALCİN, ISMAİL YALCİN, "Synthesis, Antimicrobial Activities of New Sulfonamidobenzoxazoles and Molecular Docking Studies on Escherichia coli TEM-1 β-Lactamase", Croatica Chemica Acta, 90(1), 67-74 (2017). DOI: 10.5562/cca3111.
  68. TUGBA ERTAN-BOLELLİ*, KAYHAN BOLELLİ, YAMAN MUSDAL, ILKAY YİLDİZ, ESİN AKİ-YALCİN, BENGT MANNERVİK, ISMAİL YALCİN, "Design and synthesis of 2-substituted-5-(4-trifluoromethylphenylsulphonamido)benzoxazole derivatives as human GST P1-1 inhibitors", Artificial Cells, Nanomedicine, and Biotechnology, 45, 1-8 (2017). Doi: 10.1080/21691401.2017.1324464.
Other International Journals
  1. TURKER, L., SENER, E., YALÇIN, I., AKBULUT, U., KAYALIDERE, I., QSAR of Some Antifungal Active Benzoxazoles Using The Quantum Chemical Parameters, Scientica Pharmaceutica, 58, 107-113 (1990).
  2. YALCIN, I., SENER, E. and OREN, I., QSAR of some antibacterial active isosteric heterocyclic compounds against an enterobacter. In Wermuth, C. G. (Ed.) Trends in QSAR and Molecular Modelling 92. Escom, Leiden, pp. 570-572 (1993).
  3. GULLU, M., YALCIN, I., SENER, E., TURKER, L., CELEBI, N., AKBULUT, U., Relationships between Cathodic Peak Potentials and Theoretically Calculated LUMO Energies of Some 2-Phenybenzoxazole Derivatives, Bulletin Soc. Chim. Belg, 103(3), 87-90 (1994).
  4. YALCIN, I., SENER, E., OREN, I., TEMIZ, O., Determination of the activity contributions of some novel isosteric heterocyclics against an enteric gram-negative rod using the Free-Wilson analysis. In Sans, F., Giraldo, J. and Manaut, F. (Eds.) QSAR and Molecular Modelling:Concepts, Computational Tools and Biological Applications. Prous, Barcelona, pp. 147-151 (1995).
  5. TURKER, L., GULLU, M., YALCIN, I., SENER, E., CELEBI, N., Relationships Between Theoretically Calculated LUMO Energies and Cathodic Peak Potentials of Some 2-Benzylbenzoxazole Derivatives, Bulletin Soc Chim. Belg, 105 (6), 303-306 (1996).
  6. TEMIZ-ARPACI, O., TEKINER-GULBAS, B., YILDIZ, I., AKI-SENER, E., YALCIN, I., "3D-QSAR Analysis on Benzazole Derivatives as Eukaryotic Topoisomerase II Inhibitors by using Comparative Molecular Field Analysis Method", QSAR and Molecular Modelling in Rational Design of Bioactive Molecules, Istanbul-Turkey, September 5-10, 2004, AKI-ŞENER, E., YALÇIN, İ. (Eds.), Başkent Publishing, Ankara, (2006).
  7. TURKER, L., SENER, E., YALÇIN, I., AKBULUT, U., KAYALIDERE, I., QSAR of Some Antifungal Active Benzoxazoles Using The Quantum Chemical Parameters, Scientica Pharmaceutica, 58, 107-113 (1990).
  8. YALCIN, I., SENER, E. and OREN, I., QSAR of some antibacterial active isosteric heterocyclic compounds against an enterobacter. In Wermuth, C. G. (Ed.) Trends in QSAR and Molecular Modelling 92. Escom, Leiden, pp. 570-572 (1993).
  9. GULLU, M., YALCIN, I., SENER, E., TURKER, L., CELEBI, N., AKBULUT, U., Relationships between Cathodic Peak Potentials and Theoretically Calculated LUMO Energies of Some 2-Phenybenzoxazole Derivatives, Bulletin Soc. Chim. Belg, 103(3), 87-90 (1994).
  10. YALCIN, I., SENER, E., OREN, I., TEMIZ, O., Determination of the activity contributions of some novel isosteric heterocyclics against an enteric gram-negative rod using the Free-Wilson analysis. In Sans, F., Giraldo, J. and Manaut, F. (Eds.) QSAR and Molecular Modelling:Concepts, Computational Tools and Biological Applications. Prous, Barcelona, pp. 147-151 (1995).
  11. TURKER, L., GULLU, M., YALCIN, I., SENER, E., CELEBI, N., Relationships Between Theoretically Calculated LUMO Energies and Cathodic Peak Potentials of Some 2-Benzylbenzoxazole Derivatives, Bulletin Soc Chim. Belg, 105 (6), 303-306 (1996).
  12. TEMIZ-ARPACI, O., TEKINER-GULBAS, B., YILDIZ, I., AKI-SENER, E., YALCIN, I., "3D-QSAR Analysis on Benzazole Derivatives as Eukaryotic Topoisomerase II Inhibitors by using Comparative Molecular Field Analysis Method", QSAR and Molecular Modelling in Rational Design of Bioactive Molecules, Istanbul-Turkey, September 5-10, 2004, AKI-ŞENER, E., YALÇIN, İ. (Eds.), Başkent Publishing, Ankara, (2006).
National Papers
  1. NOYANALPAN, N., SENER, E., “Synthesis, Structure Elucidation and Antihistaminic Activities of 2-(p-Substitutedbenzyl)benzoxazole Derivatives” FABAD J. of Pharmaceutical Sciences, 10(4), 275-286 (1985) (Turkish).
  2. YALÇIN, I., ŞENER, E., ÖZDEN, T., “Synthesis and Structure Elucidation of 2-(p-Substitutedphenyl)oxazolo (4,5-b)pyridine Derivatives” J. of Ankara University Faculty of Pharmacy, 15(1), 67-78 (1985) (Turkish).
  3. NOYANALPAN, N., ŞENER,.E., “Synthesis, Structure Elucidation and Antihistaminic Activities of 5-Chloro-2-(p-Substitutedbenzyl)benzoxazole Derivatives”, FABAD J. of Pharmaceutical Sciences,  11(1), 22-30 (1986) (Turkish).
  4. NOYANALPAN, N., ŞENER, E., “Synthesis, Structure Elucidation and Antihistaminic Activities of 5-Nitro-2-(p-Substitutedbenzyl)benzoxazole Derivatives”, FABAD J. of Pharmaceutical Sciences,  11(2), 111-119 (1986) (Turkish).
  5. ŞENER, E., ÖZDEN, S., YALÇIN, İ., ÖZDEN, T. , AKIN, A., YILDIZ, S.,  “Synthesis, Structure Elucidation and Microbiological Activities of 2-(p-Substitutedphenyl)benzoxazole Derivatives” J. of Ankara University Faculty of Pharmacy, 11(3), 190-202 (1986) (Turkish).
  6. YALÇIN, İ., ŞENER, E., ÖZDEN, T., ÖZDEN, S., AKIN, A., YILDIZ, S., “Synthesis, Structure Elucidation and Microbiological Activities of 5-Chloro-2-(p-Substitutedphenyl)benzoxazole Derivatives” FABAD J. of Pharmaceutical Sciences, 11(4), 257-269 (1986) (Turkish).
  7. ÖZDEN, S., ÖZDEN, T., ŞENER, E., YALÇIN, İ., AKIN, A., YILDIZ, S., “Synthesis, Structure Elucidation and Microbiological Activities of 5-Nitro-2-(p-Substitutedphenyl)benzoxazole Derivatives” FABAD J. of Pharmaceutical Sciences, 12(1), 39-47 (1986).
  8. YALÇIN, İ., ŞENER, E., ÖZDEN, S., AKIN, A., YILDIZ, S., The Quantitative Structure-Activity Relationships and Antibacterial Activty of 2-(p-Substitutedphenyl) oxazole(4,5-b)pyridine derivatives Against Streptococcus faecalis ve Staphylococcus aereus, FABAD J. of Pharmaceutical Sciences, 12(3), 213-222 (1987).
  9. ŞENER, E., YALÇIN, İ., E., ÖZDEN, S., ÖZDEN, T., The Quantitative Structure-Activity relationships of Antibacterial Active 2-(p-Substitutedphenyl)benzoxazole derivatives Against Gram (-) Bacteria Using The Combinations of Some Hydrophobic, Electronic and Steric Paramaters, J. of Gazi University Faculty of Pharmacy, 3(2), 133-142 (1986).
  10. YALÇIN, İ., ŞENER, E.,., ÖZDEN, S., ÖZDEN, T., The Quantitative Structure-Activity relationships of Antibacterial Active 2-(p-Substitutedphenyl)benzoxazole Derivatives Against Candida albicans Using The Combinations of Some Hydrophobic, Electronic and Steric Paramaters, J. of Ankara University Faculty of Pharmacy,16(1), 24-30 (1986).
  11. YALÇIN, İ., ŞENER, E., E., ÖZDEN, S., ÖZDEN, T., The Quantitative Structure-Activity relationships of Antibacterial Active 2-(p-Substitutedphenyl)benzoxazole Derivatives Against Gram (+) Bacteria Using The Combinations of Some Hydrophobic, Electronic and Steric Paramaters, FABAD J. of Pharmaceutical Sciences, 12(1), 48-55  (1987).
  12. ŞENER, E., YALÇIN, İ., ÖZDEN, S., ÖZDEN, T. , AKIN, A., YILDIZ, S., The Antifungal Activity of 2-(p-Substitutedphenyl)oxazolo(4,5-b)pyridine Derivatives Against  Candida albicans and The Quantitative Structure-Activity Relationships, FABAD J. of Pharmaceutical Sciences, 12(4), 281-288 (1987).
  13. ŞENER, E., YALÇIN, İ., E., ÖZDEN, S., ÖZDEN, T. , AKIN, A., YILDIZ, S., Synthesis and Antimicrobial Activities of 5-Amino-2-(p-substitutedphenyl)-benzoxazole Derivativies, Doga Turkish Journal of Medicine and Pharmacy, 11(3), 391-396 (1987).
  14. ŞENER, E., YALÇIN, İ., AKIN, A., NOYANALPAN, N., Antifungal Activity of 2-Benzylbenzoxazole Derivativies and QSAR’s by Free-Wilson Analysis, J. of Gazi University Faculty of Pharmacy, 4(1), 1-9 (1987).
  15. YALÇIN, İ., ŞENER, E., ÖZDEN, S., ÖZDEN, T., AKIN, A., YILDIZ, S., The Antibacterial Activity of 2-Phenyloxazolo (4,5-b)pyridine Derivatives Against Gram(-) Bacteria and The Quantitative Structure-Activity Relationships, FABAD J. of Pharmaceutical Sciences, 13(3), 441-449 (1988).
  16. ŞENER, E., TEMİZ, Ö., ÖREN, İ., YALÇIN, İ., AKIN, A., UÇARTÜRK, N., Synthesis, Antibacterial Activity and QSARs of Some 5-Substituted-2-(p-substitutedbenzyl)benzoxazoles Using The Free-Wilson Analysis, J. of Ankara University Faculty of Pharmacy, 24(1), 10-20, (1995).
Reviews
  1. BÜYÜKBINGÖL, E., ŞENER, E., “Quantitative Structure-Activity Relationships in Medicinal Chemistry” Pharmacia-J of Turkish Pharmacy Association, 24: 52(2), 126-133, (1984) (Turkish).
  2. YALÇIN, İ., ŞENER, E., “The Quantitative Structure-Activity Relationships of Selective Antiinflammatuary Active Nonacidic Poliaryl Heterocyclic Compounds”, FABAD J. of Pharmaceutical Sciences, 10(3), 183-194 (1985) (Turkish).
  3. ŞENER, E., YALÇIN, İ., “The Role of Histamine in Inflammation, The Effects of Antihistaminics in Inflammation and Antiinflammatory Compounds Against Histamine , J of Ankara Pharmacy Chamber, 8(2),99-110 (1986) (Turkish).
  4. YALÇIN, İ., ŞENER, E., Research and Development Studies on Antiinflammatory, Analgesic and Antipiretic Kinazolone Derivatives” J of Ankara Pharmacy Chamber, 8(4), 269-276 (1986) (Turkish).
  5. Ö TEMİZ, Ö., ŞENER, E., Microbiological Activity Benzoxazole, Benzimidazole, Benzothiazole ve Oxazolo(4,5-b)pyridine Derivatives, J. of Ankara University Faculty of Pharmacy, 21(1-2), 36-52, (1992).
  6. Ö TEMİZ, Ö., ŞENER, E., “New Benzodiazepine Derivatives and Their Biologic Activities, J. of Ankara University Faculty of Pharmacy, 23(1-2), (1994) (Turkish).
  7. YALÇIN, İ., ŞENER, E., “The Importance, Design and Development of Original Drug Studies in Turkey” Reports of Turkish Drug and Chemistry, 99-100-101, s. 4-5 (1996) (Turkish).
  8. ALPER, S., TEMİZ-ARPACI, Ö., AKI-ŞENER, E., YALÇIN, İ.,”Some New bi-and ter-benzimidazole Derivatives as Topoisomerase I Inhibitors”, Il Farmaco, 58, 497-507, (2003).
Books
  1. ESİN AKI-ŞENER, İSMAİL YALÇIN, “Drug Design Methods in Pharmaceutical/Medicinal Chemistry-I, Quantitative Structure-Activity Relationship Analysis (QSAR)”, Ankara University Faculty of Pharmacy Publications, No:86, ISBN 975-482-585-8, Ankara University Press, 2003, 323 pages (Turkish).
  2. “Pharmaceutical Chemistry Practices-I” Ankara University Press, 2004, ISBN 975-482-649-8, 18 Authors, (Turkish).
  3. “Pharmaceutical Chemistry Practices-I” Ankara University Press,2004, ISBN 975-482-668-4, 18 Authors, (Turkish).
  4. "QSAR & Molecular Modelling in Rational Design of Bioactive Molecules, Proceeding Book of the 15th European Symposium on Structure-Activity Relationships (QSAR) and Molecular Modelling", Esin AKI (SENER) and Ismail YALCIN (Eds.), printed by Başkent Publishing, ISBN 975-00782-0-9, 2006.

Medicinal Chemistry and Drug Design Flyer