Chaur-Dong Hsu, MD, MPH, FACOG
Xiaojun Yu, PhD
Associate Professor of Biomedical Engineering

  • Department of Biomedical Engineering, Chemistry and Biological Sciences
    Stevens Institute of Technology
    Hoboken, New Jersey, USA
    Phone: + (201) 216-5256
    E-mail: xyu@stevens.edu

Education

Tsinghua University, Beijing, China

BE

1989

Chemical Engineering

Peking Union Medical College, Beijing, China

MS

1992

Biomedical Engineering

Case Western Reserve University, Cleveland, OH

PhD

2002

Biomedical Engineering

 

Biography

Xiaojun Yu is an associate Professor of Biomedical Engineering in the Department of Biomedical Engineering, Chemistry and Biological Sciences at Stevens Institute of Technology, Hoboken, New Jersey, USA. He received his PhD in Biomedical Engineering in 2002 from Case Western Reserve University, Cleveland, Ohio, USA. His research interests include Nanobiotechnolgy, Biomaterials, Tissue Engineering and Drug Delivery. He has published over 60 refereed papers. His research has been supported by NIH, DOD, NSF and several private foundations. He has served as number of technical and proposal reviewers and panel member for NSF, NIH and DOD. He is also a journal referee for number of journals.

 

Research Interest

Dr. Xiaojun Yu’s research focuses on tissue engineering, biomaterials, drug delivery, and nanobiotechnology. In the biomaterials area, Dr. Yu is interested in the biomimetic design of biomaterials through various physical, chemical and biological modifications of biodegradable synthetic polymers and nature-derived biomaterials for biomedical applications. In the tissue engineering area, Dr. Yu is interested in engineering scaffolds with various structures and biological cues in mimic the native tissues. In the area of drug delivery, Dr. Yu is interested in developing controlled and targeted drug delivery systems for delivering growth factors, anti-cancer drugs, and antibiotics. In the nanobiotechnology area, Dr. Yu is interested in investigating nanoparticles for delivering drugs and genes. Dr. Yu’s current research activities include nano- and micro-scale functionalization of biomimetic 3D scaffolds for neural and musculoskeletal tissue repair and regeneration, investigation of cell and material interactions in 2D, 3D and in bioreactors, development of controlled release systems for the delivery of growth factors and drugs, and manipulation of the microenvironment for stem cell proliferation and differentiation.

Scientific Activities:

Experience

1992 – 1995

Research Scientist

Biomedical Engineering, Peking Union Medical College, Beijing, China

1996 – 2001

Graduate Research Assistant

Biomedical Engineering, Case Western Reserve University, Cleveland, OH

2005—2011

Assistant Professor

Department of Chemical, Biomedical and Materials Engineering,
Stevens Institute of Technology, Hoboken, NJ

2011-Present

Associate Professor

Department of Biomedical Engineering, Chemistry, and Biological Sciences, Stevens Institute of Technology, Hoboken, NJ

 

Publications

  1. Valmikinathan CM, Hoffman J, and Yu X. “Impact of scaffold micro and macro architecture on Schwann cell proliferation under dynamic conditions in a rotating wall vessel bioreactor”, Materials Science and Engineering C 31: 22–29, 2011.
  2. Wang JP, Shah A, and Yu. X., “The influence of fiber thickness, wall thickness and gap distance on the spiral nanofibrous scaffolds for bone tissue engineering”, Materials Science and Engineering C. 31: 50–56, 2011.
  3. Valmikinathan CM, Hoffman J, and Yu X. “Impact of scaffold micro and macro architecture on Schwann cell proliferation under dynamic conditions in a rotating wall vessel bioreactor”, Materials Science and Engineering C 31: 22–29, 2011.
  4. Ergun A, Yu X, Valdevit A, Ritter A, Kalyon DM. In vitro analysis and mechanical properties of twin screw extruded single-layered and coextruded multilayered poly(caprolactone) scaffolds seeded with human fetal osteoblasts for bone tissue engineering, J Biomed Mater Res A. 99(3):354-66, 2011.
  5. Wang JP, Zhu YZ, Bawa HK, Ng G, Wu Y, Libera M, van der Mei, HC, Busscher HJ, and Yu X. Oxygen-Generating Nanofiber Cell Scaffolds with Antimicrobial Properties. Applied materials and Interfaces, 3(1): 67 -73, 2011.
  6. Wu Y, Zitelli JP, TenHuisen KA, Yu X, and Libera MR. “Differential response of Staphylococci and osteoblasts to varying titanium surface roughness”. Biomaterials, 32(4):951-60, 2011.
  7. Pavlukhina SV, Kaplan JB, Xu L, Chang W, Yu X, Madhyastha S, Yakandawala N, Mentbayeva A, Khan B, Sukhishvili SA."Noneluting enzymatic antibiofilm coatings." ACS Applied Materials and Interfaces 4(9): 4708-4716, 2012.
  8. Valmikinathan CM, Chang W, Xu J, and Yu X. Self assembled temperature responsive surfaces for generation of cell patches for bone tissue engineering. Biofabrication, 4(3):035006, 2012.
  9. Ergun A, Yu X, Valdevit A, Ritter A and Kalyon DM, “Radially and axially-graded multi-zonal scaffolds targeting critical-sized bone defects from polycaprolactone/hydroxyapatite/tricalcium phosphate”, Tissue Engineering A, 18(23-24): 2426-2436, 2012.
  10. Wang J, Örnek-Ballanco C, Xu J, Yang W, and Yu X, Preparation and characterization of vinculin-targeted polymer–lipid nanoparticle as intracellular delivery vehicle. Int J Nanomedicine. 8: 39–46, 2013.
  11. Pesirikan N, Chang W, Zhang X, Xu J, and Yu X. Characterization of Schwann Cells in Self Assembled Sheets from Thermo-responsive Substrates. Tissue Engineering Part A, 9(13-14):1601-9, 2013.
  12. Wang Q., Yu X., Libera M. Reducing Bacterial Colonization of 3-D Nanofiber Cell Scaffolds by Hierarchical Assembly of Microgels and an Antimicrobial Peptide. Advanced Healthcare Materials. 5; 687-691, 2013.
  13. Aravamudhan A, Ramos DM, Nip J, Harmon MD, James R, Deng M, Laurencin CT, Yu X, and Kumbar SG. Cellulose and Collagen Derived Micro-Nano Structured Scaffolds for Bone Tissue Engineering. J. Biomed. Nanotechnol. 9, 719-731, 2013.
  14. Aravamudhan A, Ramos DM, Nip J, Subramaniam A, James R, Harmon MD, Yu X and Kumbar SG. Osteoinductive Small Molecules: Growth Factor Alternatives for Bone Tissue Engineering. Current Pharmaceutical Design, 19, 3420-3428, 2013.
  15. Norapath Pesirikan, Wei Chang, Xiaojun Zhang, Jiahua Xu, and Xiaojun Yu. Characterization of Schwann Cells in Self Assembled Sheets from Thermo-responsive Substrates. Tissue Engineering Part A, 9(13-14):1601-9, 2013.
  16. Radoslaw Junka, Chandra M. Valmikinathan, Dilhan M. Kalyon, and Xiaojun Yu. Laminin Functionalized Biomimetic Nanofibers for Nerve Tissue Engineering. J. Biomater. Tissue Eng. 3, 494-502, 2013.
  17. Junka R, Valmikinathan CM, Kalyon DM, and Yu X. Laminin Functionalized Biomimetic Nanofibers for Nerve Tissue Engineering. J. Biomater. Tissue Eng. 3, 494-502, 2013.
  18. Evensen N, Li J, Yang J, Yu X, Sampson NS, Zucker S, Cao J. Development of A High-throughput Three-dimensional Invasion Assay for Anti-cancer Drug Discovery. PLoS One. 2013 Dec 11;8(12):e82811.
  19. Chang W, DeVince J, Green G, Johns M, Shah M, Meng Y and Yu X. The development of a novel normalization method for comparing nerve regeneration effectiveness among different graft types. Journal of Peripheral Nervous System, 2013 Oct 11. doi: 10.1111/jns5.12043. [Epub ahead of print].
  20. Cheng Y, Ramos D, Lee P, Liang D, Yu X, and Sangamesh G. Kumbar. Collagen Functionalized Bioactive Nanofiber Matrices for Osteogenic Differentiation of Mesenchymal Stem Cells: Bone Tissue Engineering. J. Biomed. Nanotechnol. 10(2):287-98, 2014.
  21. Lee P, Tran K, Chang W, Shelke NB, Kumbar SG, and Yu X. Influence of Chondroitin Sulfate and Hyaluronic Acid Presence in Nanofibers and its Alignment on the Bone Marrow Stromal Cells: Cartilage Regeneration. Journal of Biomedical Nanotechnology, 10: 1-11, 2014.
  22. Zhang X, Chang W, Lee P, Wang Y, Yang M, Li J, Kumbar SG, Yu X. Polymer-ceramic spiral structured scaffolds for bone tissue engineering: effect of hydroxyapatite composition on human fetal osteoblasts. PLoS One. 2014 Jan 27;9(1):e85871.
  23. Evaluating nerve guidance conduits for peripheral nerve injuries: a novel normalization method. Munish Shah, Wei Chang, and Xiaojun Yu. Neural Regeneration Research. 9(22): 1959-1960, 2014.
  24. Pavlukhina S., Zhuk I., Mentbayeva A., Rautenberg E., Chang W., Yu X., Van De Belt-Gritter B., Busscher H.J., Van Der Mei H.C., Sukhishvili S.A. Small-molecule-hosting nanocomposite films with multiple bacteria-triggered responses. Volume: 6 Issue: 8 Art. No.: e121 NPG Asia Materials, 2014.
  25. In-Situ Gelling Polysaccharide Based Hydrogel for Cell and Drug Delivery in Tissue Engineering. Cheng, Y., Nada, A.A, Valmikinathan, C.M., Lee, P., Liang. D., Yu, X., and Kumbar, S.G. J. Appl. Polym. Sci., 131, 39934, 2014.
  26. Paul Lee, Katelyn Tran, Gan Zhou, Asheesh Bedi, Namdev B. Shelke, Xiaojun Yu and Sangamesh G. Kumbar. Guided Differentiation of Bone Marrow Stromal Cells on Co-Cultured Cartilage and Bone Scaffolds. Soft Matter, 11(38):7648-55, 2015.
  27. Paul Lee, Katelyn Tran, Gan Zhou, Asheesh Bedi, Namdev B. Shelke, Xiaojun Yu and Sangamesh G. Kumbar. Guided Differentiation of Bone Marrow Stromal Cells on Co-Cultured Cartilage and Bone Scaffolds. Soft Matter, 11(38):7648-55, 2015.
  28. Radoslaw Junka and Xiaojun Yu. Novel Acellular Scaffold Made from Decellularized Schwann Cell Sheets for Peripheral Nerve Regeneration. Regen. Eng. Transl. Med. doi:10.1007/s40883-015-0003-2, 2015.
  29. Shelke N.B., Lee P., Anderson M., Mistry M., Nagarale R.K., Ma X.M., Yu X., Kumbar S.G., Neural Tissue Engineering: Nanofiber-Hydrogel Based Composite Scaffolds. Polym. Adv. Technol., DOI: 10.1002/pat.3594. 2015.

 

     
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