Professor of Medicine
-
Michigan State University
East Lansing, Michigan, USA
Phone: + (517) 432-0797
E-mail: Donna.Wang@hc.msu.edu
Education
| M.D | 09/79-08/84 | Sun Yat Sen University School of Medicine, Guangzhou, China |
| Resident | 08/84 - 09/85 | Sun Yat-Sen Ophthalmic Center, Sun Yat-Sen University School of Medicine, Guangzhou, China |
| Visiting Scholar | 09/85 - 11/87 | Departments of Surgery and Physiology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC |
| Postdoctoral Fellow | 12/87 - 01/90 | Department of Physiology, Eastern Virginia Medical School, Norfolk, VA. Mentor: Russell L. Prewitt |
Experience
| 02/08-present | Distinguished Professor, Michigan State University, MI |
| 02/08-present | Distinguished Professor, College of Human Medicine, Michigan State University, MI |
| 01/00-present | Professor, Neuroscience Program and Cell & Molecular Biology Program, Michigan State University, MI |
| 06/08-present | Chief, Division of Nanomedicine and Molecular Intervention, Department of Medicine, College of Human Medicine, Michigan State University, MI |
| 06/99-present | Vice Chair for Research, Department of Medicine, College of Human Medicine, Michigan State University, MI |
| 06/99 –present | Director of Investigative Medicine, Department of Medicine, College of Human Medicine, Michigan State University, MI |
| 06/99-present | Professor (Tenured), Department of Medicine, College of Human Medicine, Michigan State University, MI |
| 09/97- 06/99 | Associate Professor (Tenured), Department of Internal Medicine, Division of General Medicine, The University of Texas Medical Branch, Galveston, TX |
| 09/94- 06/99 | Scientist, Sealy Center for Molecular Cardiology, The University of Texas Medical Branch, Galveston, TX |
| 09/94 - 07/97 | Director, Histochemical Core, Sealy Center for Molecular Cardiology, The University of Texas Medical Branch, Galveston, TX |
| 08/93 - 09/97 | Assistant Professor (Tenure-Track), Department of Internal Medicine, Division of General Medicine, The University of Texas Medical Branch, Galveston, TX |
| 02/90 - 08/93 | Assistant Professor (Research), Department of Physiology, Eastern Virginia Medical School, Norfolk, VA |
| 12/87 - 01/90 | Research Associate, Department of Physiology, Eastern Virginia Medical School, Norfolk, VA |
Biography
Donna Wang, MD, FAHA, is Professor of Medicine, Neuroscience Program, and Cell and Molecular Biology Program at Michigan State University. Dr. Wang is an Established Investigator of American Heart Association, a Fellow of the American Heart Association Council for High Blood Pressure Research, and a Fellow of Cardiovascular Section of the American Physiological Society. Dr. Wang's research interests lie in molecular intervention, neuroscience, cardiovascular medicine, drug discovery, and nanomedicine. Her laboratory discovered that the transient receptor potential (TRP) channels play a central role in the “salt pathway”. These molecules signal a particularly exciting breakthrough, as they are capable of protecting tissues/organs from inflammation and injury. Specifically, data from her laboratory indicate that TRP channels, activated by novel lipid metabolites, may serve as distinct molecular sensors detecting micro-environmental changes occurred under pathophysiologic conditions including hypertension, myocardial infarction, and metabolic disorders including diabetes and obesity.
Research Interest
- Cardiovascular medicine
- Neurobiological science
- Nanotechnology
- Drug discovery
Scientific Activities
Honors and Award
| 08/84 | Graduated Magna Cum Laude from Sun Yat-Sen University of Medical Sciences |
| 09/85 | First Selected Exchange Scholar from Sun Yat-Sen University of Medical Sciences to Bowman Gray School of Medicine (Sister Schools) |
| 04/91 | 1991 Losartan Young Investigator Travel Award from Merck & Co. |
| 07/93 - 06/98 | NIH First Independent Research Support Transition (FIRST) Award |
| 09/94 - 09/96 | The Goldblatt Award for the Most Outstanding Research from the American Heart Association Council for High Blood Pressure Research, Finalist. |
| 05/95-05/97 | Section Editor, Hypertension |
| 09/95 | Fellow: American Heart Association Council for High Blood Pressure Research |
| 10/95 | NIH Scholarship Award at the Conference of “Gene Therapy for Acquired 30 Disease”, National Heart, Lung, and Blood Institute |
| 04/96 | Invited Keynote Speaker at the President-elect's Symposium of 1996 Microcirculation Society Meeting |
| 03/97 | The Inter-American Society of Hypertension 1997 Travel Award |
| 04/97 | 1997 Outstanding Young Investigator Travel Award from the Microcirculatory Society |
| 09/97 | Awarded Tenure at University of Texas Medical Branch at Galveston |
| 01/98 | Editorial Board, Hypertension |
| 05/98 | Hoechst Marion Roussel 1998 Young Scholar Award from the American Society of Hypertension |
| 05/98 | Invited keynote Speaker at the 1st International Congress on "Function and Clinical Perspectives of Angiotensin AT1 Receptors: Cardiovascular and Renal Function in Health and Disease", Budapest, Hungary |
| 06/98 | 1998 Losartan Award from the International Society of Hypertension |
| 01/99 –12/03 | American Heart Association Established Investigator Award, National Center |
| 04/99 | Fellow: Cardiovascular Section of the American Physiological Society |
| 06/99 | 1999 Angiotensin II Young Investigator Award from Merck & Co. |
| 06/99 | Awarded Tenure at Michigan State University |
| 09/99 | NIH Scholarship Award at the Conference of “Genetic Approaches in Complex Heart, Lung, and Blood Diseases”. |
| 09/99 – 09/02 | Section Editor, Hypertension |
| 12/00 | Who’s Who in the World, published by Marquis |
| 12/00 | Editor, Angiotensin Protocol, Methods in Molecular Medicine, Humana Press |
| 6/00 | Invited Keynote Speaker at the 2nd International Congress on “Angiotensin II Receptor Blockade – Effects Beyond Blood Pressure Control”, Prague, Czech Republic |
| 10/00-9/04 | National Peer Review Committee of American Heart Association |
| 6/00 | NIH Study Section Ad Hoc Member, Experimental Cardiovascular Sciences, Center for Scientific Review, NIH/NHLBI |
| 3/01 | Guest Review Board, Hypertension |
| 4/01 | NIH Special Emphasis Panel Review, Center for Scientific Review, NIH/NHLBI |
| 10/01 | Who’s Who in Science and Engineering, published by Marquis |
| 10/01 | Who’s Who in America, published by Marquis |
| 07/01-10/03 | NIH Study Section Charter Member, Experimental Cardiovascular Sciences, Center for Scientific Review, NIH/NHLBI |
| 11/01 | 2000 Outstanding Intellectuals of the 21st Century, published by the International Biographical Center (IBC), Cambridge, England |
| 1/02 | Who’s Who in Medicine and Healthcare, published by Marquis |
| 1/02 | Who’s Who of American Women, published by Marquis |
| 1/02 | 2000 Outstanding Scientists of 21st Century, published by IBC, Cambridge |
| 1/02 | 21st Century Award for Achievement, published by IBC, Cambridge |
| 6/02 | 1000 Great Scientists, Published by IBC, Cambridge |
| 06/02 | International Scientist of the Year 2002, Published by IBC, Cambridge |
| 09/02 | IBC Record of Achievement, Published by IBC, Cambridge |
| 12/02 | International Who’s Who of Professionals, Who’s Who Historical Society |
| 02/03 | International Woman of the Year, Published by IBC, Cambridge |
| 03/03 | The Worldwide Honors List, Published by IBC, Cambridge |
| 03-06 | Women & Minorities Leadership Committee, American Heart Association National Center |
| 03-04 | Science Advisory and Coordinating Committee, American Heart Association National Center |
| 03-05 | Nominating and Awards Committee, American Heart Association National Center |
| 08/03 | International Health Professional of the Year 2003, Published by IBC, Cambridge |
| 08/03 | Who’s Who of Professionals, published by Marquis |
| 10/03-10/05 | NIH Study Section Charter Member, Hypertension and Microcirculation, Center for Scientific Review, NIH/NHLBI |
| 04-05 | Chair, Women & Minorities Leadership Committee, American Heart Association National Center |
| 04-06 | Advocacy Coordination Committee, American Heart Association National Center |
| 03/04 | NIH Study Section, Special Emphasis Panel Review, Center for Scientific Review, NIH/NHLBI |
| 04/04 | NIH Study Section, Special Emphasis Panel Review, Center for Scientific Review, NIH/NHLBI |
| 05/04 | Editorial Board, Current Hypertension Reviews, Bentham Science Publishers |
| 10/04 | Silver Heart Member Distinction, American Heart Association National Center |
| 11/04 | NIH Study Section, Site Visit to General Clinical Research Center, National Center for Research Resources, NIH/NCRR |
| 01/05 | Elected Member of the Sigma Xi Honor Society |
| 03/05 | NIH Study Section, Special Emphasis Panel Review, Center for Scientific Review, NIH/NHLBI |
| 03/05 | Co-Chair, NIH Study Section, Hypertension & Microcirculation, Center for Scientific Review, NIH/NHLBI |
| 04/05 | NIH Study Section, Site Visit to the Research Centers in Minority Institutes Clinical Research Infrastructure Initiative Center, National Center for Research Resources, NIH/NCRR |
| 04/05 | NIH Study Section, Special Emphasis Panel Review, Center for Scientific Review, NIH/NHLBI |
| 06/05 | Researcher of the Spotlight, College of Human Medicine, MSU |
| 04/05 | Editorial Board, Recent Patent Reviews on Cardiovascular Drug Discovery, Bentham Science Publishers |
| 06/05 | NIH Study Section, Special Emphasis Panel Review, Center for Scientific Review, NIH/NHLBI |
| 05/05 | Editorial Board, Nanomedicine, Elsevier Publishers |
| 08/05 | Invited keynote speaker at the 1st American Academy of Nanomedicine Annual Conference |
| 06/05 | Editorial Board, Journal of Cardiothoracic-Renal Research, Elsevier Publishers |
| 08/05 | Featured Researcher, M.D. Magazine, MSU |
| 12/05 | Selected as Research Highlights, Office of Vice President for Research, MSU |
| 07/05 | NIH/NCRR Study Section, Reverse Site Visit for the Centers of Clinical Research Excellence, Morehouse School of Medicine, Center for Research Resources, NIH/NCRR |
| 08/05 | NIH/NCRR Study Section, RCMI Clinical and Translational Research Network Review, Center for Research Resources, NIH/NCRR |
| 09/05 | Researcher of the Spotlight, Michigan State Research Calendar 2006-2007 |
| 11/05 | Honorary Professor, Zhejiang University College of Medicine, Zhejiang, China |
| 12/05 | Leading Health Professionals of the World, Published by IBC, Cambridg |
| 01/06- | Editorial Board of American Journal of Physiology-Heart and Circulatory Physiology |
| 01/06 | President, Academy of Cardiovascular Research Excellence |
| 01/06 | Chair of the Board, Academy of Cardiovascular Research Excellence |
| 03/06 | NIH Study Section, Special Emphasis Panel Review, Center for Scientific Review, NIH/NHLBI |
| 03/06 | Featured Professor of Innovation, the State News |
| 03/06 | Researcher of the Spotlight, Office of the Vice President for Research and Graduate Studies, MSU |
| 07/06 | NIH Study Section, Special Emphasis Panel Review, Center for Scientific Review, NIH/NHLBI |
| 10/06-09/09 | NIH Study Section Charter Member, NHLBI Institutional Training Mechanism (NITM) Standing Review Committee, Center for Scientific Review, NIH/NHLBI |
| 10/06 | Mentor of the American Heart Association |
| 05/06 | Member, Board of Directors, the American Academy of Nanomedicine |
| 05/06 | Chairperson, Michigan Chapter of the American Academy of Nanomedicine |
| 05/06 | Chairperson, Michigan Chapter of the American Academy of Nanomedicin |
| 05/06 | Chairperson, Michigan Chapter of the American Academy of Nanomedicine |
| 09/06 | Fellow, the American Academy of Nanomedicine |
| 10/06 | Faculty mentor for Youping Wang, recipient of Merck New Investigator Award, American Heart Association 60th Annual Fall Conference and Scientific Sessions of the Council for High Blood Pressure Research |
| 08/06 | Chairperson, the Council for Cardiovascular Nanomedicine, the American Academy of Nanomedicine |
| 08/06 | Associate Editor, Nanomedicine, Elsevier Publishers |
| 09/06 | 2006 Sigma Xi Senior Meritorious Faculty Award, the Sigma Xi Honorary Scientific Society |
| 11/06 | Invited Keynote Speaker at the Xiangshan International Conference on Nanomedicine and Nanobiology by Chinese Academy of Science and Department of Science and Technology |
| 01/07 | Invited Keynote Speaker at the 2nd Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems by IEEE Nanotechnology Council |
| 06/07 | Invited Keynote Speaker at the ChinaNANO International Conference 2007 by Chinese Academy of Science and National Center for Nanoscience and Technology |
| 08/07 | Invited General Chair for the 1st Annual IEEE International Conference on Nano/ Molecular Medicine and Engineering by IEEE Nanotechnology Council |
| 04/07 | 2007 Excellence Award in Interdisciplinary Scholarship, Honor Society of Phi Kappa Phi |
| 01/08 | Distinguished Faculty Award, College of Human Medicine, MSU |
| 02/08 | Distinguished Faculty Award, Michigan State University |
| 03/08 | NIH Study Section, Review Committee for George O'Brien Kidney Research Core Center, Center for Scientific Review, NIH/NIDDK |
| 12/08-11/10 | Leadership Committee, Member-At-Large, American Heart Association Council for High Blood Pressure Research |
| 11/08 | Honorary General Chair, the 2nd Annual IEEE International Conference on Nano/ Molecular Medicine and Engineering (IEEE-NANOMED), IEEE Nanotechnology Council 2008 |
| 07/09 | Who's Who Among Executives and Professionals Throughout the World, Madison Who’s Who, Inc. |
| 10/09 | Chair, Awards Committee, the 3rd Annual IEEE International Conference on Nano/ Molecular Medicine and Engineering (IEEE-NANOMED), IEEE Nanotechnology Council |
| 10/09 | Steering Committee, the 3rd Annual IEEE International Conference on Nano/ Molecular Medicine and Engineering (IEEE-NANOMED), IEEE Nanotechnology Council |
| 12/09 | Science Advisory Committee, International Symposium on Bioelectronics and Bioinformatics (ISBB), IEEE Engineering in Medicine and Biology Society |
| 12/10 | Steering Committee, the 4th Annual IEEE International Conference on Nano/ Molecular Medicine and Engineering (IEEE-NANOMED 2010), IEEE Nanotechnology Council |
| 12/10-11/12 | Leadership Committee, Member-At-Large, American Heart Association Council for High Blood Pressure Research |
| 04/11 | Citation for Distinguished Service from The American Physiological Society |
| 11/11 | Science Advisory Committee and Symposium Steering Committee, International Symposium on Bioelectronics and Bioinformatics (ISBB), IEEE Engineering in Medicine and Biology Society |
| 04/12 | Invited Speaker at the President’s Symposium of Microcirculatory Society on “The Roles of ENaC, ASIC and TRP Channels in Vascular Control” for Experimental Biology, San Diego, California |
| 05/12 | Associate Editor, Cardiovascular & Hematological Disorders - Drug Targets, Bentham Science Publishers |
| 06/12 | Invited Distinguished Faculty, the 11th International Summer School on Biocomplexity from Gene to System, co-sponsored by the National Science Foundation and the IEEE EMB Society |
| 11/12 | Golden Heart Member, American Heart Association/American Stroke Association |
| 11/13 | Invited Plenary Speaker, the 7th Annual IEEE International Conference on Nano/Molecular Medicine and Engineering (IEEE-NANOMED 2013), IEEE Nanotechnology Counci |
| 04/14 | Science Advisory Committee and Symposium Steering Committee, International Symposium on Bioelectronics and Bioinformatics (ISBB2014), IEEE Engineering in Medicine and Biology Society |
| 04/14 | Invited Plenary Speaker, International Symposium on Bioelectronics and Bioinformatics (ISBB2014), IEEE Engineering in Medicine and Biology Society |
| 05/14 | Invited International Faculty Member and Speaker, The 8th Oriental Congress of Cardiology, co-sponsored by Shanghai Society of Cardiology and Shanghai Medical Association |
Publications
- Wang YP, Babánková D, Huang J, Swain GM, Wang DH. Deletion of TRPV1 Channels Exaggerates Renal Damage in DOCA-Salt Hypertension. Hypertension 52:264-270;2008 [PMID: 18606907]
- Zhong BH, Wang DH. N-Oleoyldopamine, a Novel Endogenous Capsaicin-like Lipid, Protects the Heart against Ischemia-Reperfusion Injury via Activation of TRPV1. Am J Physiol (Heart & Circulatory Physiology) 295:H728-H735; 2008 [PMID: 18567714]
- Huang W, Wang H, Galligan JJ, Wang DH. TRPV1-Mediated Neuropeptide Secretion and Hypotension: Role of Endoplasmic Reticulum-Associated Ca2+ Release Receptors in Dorsal Root Ganglion Neurons. J Hypertension 26(10):1966-75. 2008 [PMID: 18806620]
- Gao F, Sui D, Garavito MR, Worden MR, Wang DH. Salt intake augments hypotensive effects of TRPV4: Functional significance and implication. Hypertension 53:228-235, 2009 [PMID: 19075100 ]
- Huang W, Rubinstein J, Prieto AR, Thang LV, Wang DH. Transient receptor potential vanilloid gene deletion exacerbates inflammation and atypical cardiac remodeling after myocardial infarction. Hypertension 53:243-250, 2009 [PMID: 19114647]
- Rayamajhi S, Contractor T, Wang DH. Potential of TRPV1 agonists for treating ischemia/repurfusion-induced renal injuries. Current Opinion in Investigational Drugs 10(9):963-970, 2009 [PMID: 19705339]
- Xie, CQ, Wang DH. Ablation of TRPV1 Abolishes Endothelin Induced Increases in Afferent Renal Nerve Activity: Mechanisms and Functional Significance. Hypertension 54:1298-1305; 2009 (Featured on the Cover) [NIHMSID # 161210; PMID: 19858408].
- Wang YP, Wang DH. Aggravated Renal Inflammatory Responses in TRPV1 Gene Knockout Mice Subjected to DOCA-Salt Hypertension. Am J Physiology (Renal Physiology) 297 F1550-F1559; 2009 [PMID: 19794112].
- Zhong BH, Wang DH. Protease-activated receptor 2-mediated protection of myocardial ischemia-reperfusion injury: role of transient receptor potential vanilloid receptors. Am J Physiol (Regulatory, Integrative and Comparative Physiology) 297(6):R1681-90; 2009 [PMID: 19812353]
- Gao F, Wang DH. Hypotension induced by activation of transient receptor potential vanilloid 4 channels : Role of Ca2+-activated K+ channels and sensory nerves. J Hypertension 28(1):102-10; 2010 [PMID: 19996988]
- Huang W, Rubinstein J, Prieto AR, Wang DH. Enhanced post-myocardial infarction fibrosis via stimulation of the TGFbeta-Smad2 signaling pathway: Role of TRPV1 channels. J Hypertension 28(2):367-76;2010 [PMID: 19887954]
- Gao F, Wang DH. Impairment in Function and Expression of TRPV4 in Dahl Salt-Sensitive Rats: Significance and Mechanism. Hypertension 55 (4):1018-1025; 2010 [NIHMSID # 190055, PMID: 20194297]
- Li M, Galligan J, Wang D, Fink G. The effects of celiac ganglionectomy on sympathetic innervation to the splanchnic organs in the rat. Autonomic Neuroscience 19:154(1-2):66-73;2010 [PMID: 20053590]
- Wang H, Wang DH, Galligan JJ. P2Y2 receptors mediate ATP-induced resensitization of TRPV1 expressed by kidney projecting sensory neurons. Am J Physiology (Regulatory, Integrative, and Comparative Physiology) 298(6):R1634-41. 2010 [PMID: 20335377]
- Xie, CQ, Wang DH. Effects of a High Salt Diet on TRPV-1 Dependent Renal Nerve Activity in Dahl Salt Sensitive Rats. American J Nephrology 32:194-200;2010 [PMID: 20639627]
- Yang RG, Xi N, Lai KWC, Zhong BH, Fung CKM, Qu CG, Wang DH. Nanomechanical analysis of insulinoma cells after glucose and capsaicin stimulation using atomic force microscopy. Acta Pharmacol Sin 32 (6):853-860, 2011 [PMID: 21623392]
- Yu S, Wang DH. Intrathecal injection of TRPV1 shRNA leads to increases in blood pressure in rats. Acta Physiol 203(1):139-147, 2011 [NIHMSID # 282834; PMID: 21518266; PMCID:PMC3145005 ]
- Xie CQ, Wang DH. Inhibition of renin release by arachidonic acid metabolites, 12(s)-HPETE and 12-HETE: Role of TRPV1 channels Endocrinology 152(10):3811-3819, 2011 [PMID: 21846804]
- Wang YP, Wang DH. Protective effect of TRPV1 against renal fibrosis via inhibition of TGF-β/Smad signaling in DOCA-salt hypertension. Molecular Medicine 17(11-12):1204-1212, 2011 [PMID: 21792478]
- Wang YP, Wang DH. Role of Substance P in Renal Injury during DOCA-Salt Hypertension. Endocrinology 153(12): 5972-5979, 2012 [PMID: 23024265, PMCID: PMC3512068]
- Yang R, Xi N, Lai KWC, Patterson K, Qu C, Zhong B, Wang DH. Cellular biophysical dynamics and ion channel activities detected by AFM-based nanorobotic manipulator in insulinoma <beta>-cells. Nanomedicine-NBM. Nov 22. 2012 [Epub ahead of print. PMID: 23178285]
- Wang YP, Wang DH. Role of the transient receptor potential vanilloid type 1 channel in renal inflammation induced by lipopolysaccharide in mice. American Journal of Physiology: Regulatory, Integrative, and Comparative 304(1):R1-9. 2013 [PMID 23152109; PMCID: PMC3543652.
