Education

Experience

Biography

Dominique Durand is a Professor of Biomedical Engineering and Director of the Neural Engineering Center at Case Western Reserve University in Cleveland, Ohio. He is an IEEE Fellow, also Fellow of the AIMBE, Institute of Physics and an AAAS fellow. He received an engineering degree from Ecole Nationale Superieure d'Electronique, Hydrolique, Informatique et Automatique de Toulouse, France in 1973. In 1974, he received a M.S. degree in Biomedical Engineering from Case Reserve University in Cleveland OH., worked several years at the Addiction Research Foundation of Toronto, Canada and in 1982 received a Ph.D. in Electrical Engineering from the University of Toronto in the Institute of Biomedical Engineering. He received an NSF Young Investigator Presidential Award as well as the Diekhoff and Wittke awards for graduate and undergraduate teaching and the Mortar board top-prof awards at Case Western Reserve University. He serves on several editorial boards of peer-reviewed scientific journals.

Research Interest

• Neural engineering
• Neurophysiological mechanisms of epilepsy
• Neuromodulation for the control of epilepsy
• Neural interfacing with the somatic and autonomic nervous system
• Computational neuroscience 

Scientific Activities:

• Investigator, Cleveland FES Center
• EL Lindseth Professor of Biomedical Engineering, Case Western Reserve University, Cleveland OH
• Departments of Biomedical Engineering, Neurosciences, Physiology and Biophysics, Case Western Reserve University, Cleveland OH
• Director, Neural Engineering Center, Case Western Reserve University, Cleveland OH
• Editor in chief, Journal of Neural Engineering, Case Western Reserve University, Cleveland, OH

Recent Invited Presentations

• Electrical Stimulation and Epilepsy, Grand Rounds Epilepsy, George Washington University, Washington, 2013
• Seizure Control with Electrical Stimulation: from the bench to the clinic, University of Utah, 2013
• Problems at the Peripheral Neural Interface, International Neuromodulation Society, Berlin, 2013
• Interfacing with nervous system, A neural engineering approach, Neural Engineering Translation Summer conference, Nottingham, England, 2013
• Reverse Stochastic Resonance, EMBS-Osaka, Japan, 2013
• Neural Engineering Fundamentals, Kanto Gakuin Yokohama, Japan, 2013
• Interfacing with the peripheral nervous system, EBMS summer school, Shanghai, China, 2013
• Key note lecture, 6th International Neural Engineering Conference, SanDiego, 2013 

Publications

1. Qiu C, Shivacharan RS, Zhang M, Durand DM. Can Neural Activity Propagate by Endogenous Electrical Field? J Neurosci. 2015 Dec 2;35(48):15800-11. doi: 10.1523/JNEUROSCI.1045-15.2015. PubMed PMID: 26631463; PubMed Central PMCID: PMC4666910.
2. Park HJ, Durand DM. Motion control of the rabbit ankle joint with a flat interface nerve electrode. Muscle Nerve. 2015 Dec;52(6):1088-95. doi: 10.1002/mus.24654. Epub 2015 Sep 7. PubMed PMID: 25786911; PubMed Central PMCID:  PMC4575232.
3. Dweiri YM, Eggers T, McCallum G, Durand DM. Ultra-low noise miniaturized neural amplifier with hardware averaging. J Neural Eng. 2015 Aug;12(4):046024. doi: 10.1088/1741-2560/12/4/046024. Epub 2015 Jun 17. PubMed PMID: 26083774.
4. Ladas TP, Chiang CC, Gonzalez-Reyes LE, Nowak T, Durand DM. Seizure reduction through interneuron-mediated entrainment using low frequency optical stimulation. Exp Neurol. 2015 Jul;269:120-32. doi: 10.1016/j.expneurol.2015.04.001. Epub 2015 Apr 8. PubMed PMID: 25863022; PubMed Central PMCID: PMC4446206.
5. Chiang CC, Ladas TP, Gonzalez-Reyes LE, Durand DM. Seizure suppression by high frequency optogenetic stimulation using in vitro and in vivo animal models of epilepsy. Brain Stimul. 2014 Nov-Dec;7(6):890-9. doi: 10.1016/j.brs.2014.07.034.  Epub 2014 Jul 19. PubMed PMID: 25108607; PubMed Central PMCID: PMC4259846.
6. Feng Z, Yu Y, Guo Z, Cao J, Durand DM. High frequency stimulation extends the refractory period and generates axonal block in the rat hippocampus. Brain Stimul. 2014 Sep-Oct;7(5):680-9. doi: 10.1016/j.brs.2014.03.011. Epub 2014 Apr 4. PubMed PMID: 24938914; PubMed Central PMCID: PMC4167911.
7. Park HJ, Durand DM. Motion control of the ankle joint with a multiple contact nerve cuff electrode: a simulation study. Biol Cybern. 2014 Aug;108(4):445-57. doi: 10.1007/s00422-014-0612-8. Epub 2014 Jun 18. PubMed PMID: 24939581.
8. Durand DM, Ghovanloo M, Krames E. Time to address the problems at the neural interface. J Neural Eng. 2014 Apr;11(2):020201. doi: 10.1088/1741-2560/11/2/020201. Epub 2014 Feb 6. PubMed PMID: 24503546.
9. Zhang M, Ladas TP, Qiu C, Shivacharan RS, Gonzalez-Reyes LE, Durand DM. Propagation of epileptiform activity can be independent of synaptic transmission, gap junctions, or diffusion and is consistent with electrical field transmission. J Neurosci. 2014 Jan 22;34(4):1409-19. doi: 10.1523/JNEUROSCI.3877-13.2014. PubMed PMID: 24453330; PubMed Central PMCID: PMC3898297.
10. Wang Y, Toprani S, Tang Y, Vrabec T, Durand DM. Mechanism of highly synchronized bilateral hippocampal activity. Exp Neurol. 2014 Jan; 251:101-11. doi: 10.1016/j.expneurol.2013.11.014. Epub 2013 Nov 19. PubMed PMID: 24262205; PubMed Central PMCID: PMC3902113.
11. Lee S, Ryu K, Waldo AL, Khrestian CM, Durand DM, Sahadevan J. An algorithm to measure beat-to-beat cycle lengths for assessment of atrial electrogram rate and regularity during atrial fibrillation. J Cardiovasc Electrophysiol. 2013 Feb;24(2):199–206. doi: 10.1111/jce.12014 Pubmed PMID: 23140386.
12. Lee, S; Sahadevan, J; Khrestian, C; Durand, D; Waldo, A, High Density Mapping of Atrial Fibrillation During Vagal Nerve Stimulation in the Canine Heart - Restudying the Moe Hypothesis, Journal of Cardiovascular Electrophysiology, In Press, 2013 PMID: 23210508.
13. Toprani, S and Durand DM. Fiber Tract Stimulation Can Reduce Epileptiform Activity in an in-vitro Bilateral Hippocampal Slice Preparation, In Press, Experimental Neurology, 2013, PMID: 23123405.
14. Wodlinger B, S. Rashid and DM Durand "Block of Peripheral Pain Response by High Frequency Sinusoidal Stimulation", Neuromodulation: Technology at the Neural Interface, In Press, 2013 PMID: 23294138.
15. Feng Z, Zheng X, Yu. Y and DM Durand: Functional Disconnection of Axonal Fibers Generated by High Frequency Stimulation in the Hippocampal CA1 Region in-vivo. In Press, Brain Research , 2013. PMID: 23473842.
16. Koubeissi MZ, Kahriman E, Syed TU, Miller J, Durand DM. Low Frequency electrical stimulation of a fiber tract in temporal lobe epilepsy. Ann Neurol. 2013.23915. [Epub ahead of print] PMID: 23613463
17. Toprani, S and Durand DM. Long-lasting hyperpolarization underlies seizure reduction by low frequency deep brain electrical stimulation, In Press, J. Neurophysiology, 2013.
18. Gonzales, L., TP Ladas; CC Chiang; DM Durand, TRPV1 antagonist capsazepine suppresses 4-AP-induced epileptiform activity in vitro and electrographic seizures in vivo. Experimental Neurology, in Press, 2013
19. Yang Wang; Sheela Toprani; Yuang Tang; Tina Vrabec; Dominique M Durand Mechanism of Highly Synchronized Bilateral Hippocampal Activity Corresponding Experimental Neurology, In Press 2013.
20. Mingming Zhang¬¬, Thomas P. Ladas, Chen Qiu, Rajat S. Shivacharan, Luis E. Gonzalez-Reyes, Dominique M. Durand Propagation of epileptiform activity can be independent of synaptic transmission, gap junctions or diffusion and is consistent with electrical field transmission, In Press, J. Neuroscience, 2013.
21. Tang Y, Wodlinger B, Durand DM. An algorithm for source signal extraction from the peripheral nerve. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:4251–4254. doi: 10.1109/IEMBS.2011.6091055 Pubmed PMID: 22255278.