Chaur-Dong Hsu, MD, MPH, FACOG
Chenzhong Li, PhD
Professor of Nanobioengineering/Bioelectronics Lab
  • Department of Biomedical Engineering
    Florida International University
    Miami, Florida, USA
    Phone: + 305 348 0120


M.Sc (Electrochemistry)

Kumamoto University in Japan

Ph.D (Bioengineering)

Kumamoto University in Japan


Principal Investigator

Biomedical Engineering Department at Florida International University

Post-Doctoral Research Associate

University of British Columbia

Professional Research Associate

University of Saskatchewan



Prof. Chenzhong Li, is the principal investigator of the nanobioengineering/bioelectronics Lab, in the Biomedical Engineering Department at Florida International University (Miami). Dr. Li received his M.Sc (Electrochemistry) and PhD (Bioengineering, 2000) from Kumamoto University in Japan. Dr. Li served as a post-doctoral research associate at the University of British Columbia and as professional research associate at the University of Saskatchewan and Adnavance Technologies, Inc. He worked at Nanobiotechnology/Biosensor Group of Biotechnology Research Institute,Canada National Research Council as Research Officer till 2006. He joined in FIU in 2006 and he is a tenured professor in the Department of Biomedical Engineering and an affiliated faculty in the Department of Immunology at the College of Medicine.

The impact of his work is documented in 9, about 130 peer-reviewed journal papers, 3 books, 7 book chapters, over 150 presentations at National/International conferences including more than 110 keynote/invited lectures and seminars. As of January 2014, his publications have been cited approximately 5000 times, for an H index of 34, as calculated by the ISI web of science.

In addition to his research activities in the USA, Dr Li has established broad international research collaboration with top level research groups in China, Japan, India, Turkey and Kazakhstan, all of which are financially supported by government agencies including NSF (USA), Japan Society for the Promotion of Science (JSPS), Indo-USA foundations (India), National Natural Science Foundation of China (NSFC), the Science and Technological Research Council of Turkey (Tübitak) and the Ministry of Education and Science of the Republic of Kazakhstan (MESKZ). His service to the biomedical engineering profession has also been quite extensive. He is the associate editor of 4 scientific journals including Applied Biochemistry and Biotechnology, the Biosensors Journal, PLOS one, and Chemical Sensors, as well as being a reviewer and panelist for NIH, NSF, NSERC (Canada) and NSFC (China). Dr Li is organizer and chairperson of several conferences and symposiums including the 25th Southern Biomedical Engineering Conference, the 4th Florida Nanoscience and Nanotechnology Conference (NanoFlorida 2011), and symposia at multiple annual Pittcon national meetings.


Research Interest

Prof. Chenzhong Li is an expert in bioelectronics, specifically in the development of biomedical devices such as wearable/portable biosensors. Prof. Chenzhong Li research interest includes:

  • Point Care of Testing’s
  • Wireless diagnostics,
  • Cell electronics
  • Organ on chips,
  • Neuron-device interface
  • Biomarker and nanotoxicity measurements
  • Electron transfer study of various biomolecules

Scientific Activities:

  1. Chenzhong Li, Chang Liu, “Surface Plasmon Resonance Based Sensing Devices and Methods for Real-Time Analysis of Analyte Secretion From Living Cells”; Provisional patent, 2013, US 14/198,814. USPTO.
  2. Wu Zezhi, Zhang Liguang, Song Zhaoyuan, Lin Yu, Luo Meirong, Huang Qiping, Liao Yanjian, Jin Liang, Li Chenzhong, William S.Saarada, Chen Jinglong,“Cell potassium electrode property detection method based on Nernst electric potential fluorochrome”, 2013,CN102393451 B.
  3. S. Prabhulkar, C.-Z. Li, “Electrochemical Micro-Immunosensor for Direct Detection of Amyloid Beta”, Provisional Patent, Filed in June, 2010. Serial No:61/332124.USPTO.
  4. C-Z. Li, and J.H. Luong “Impedance sensing of DNA binding drugs using gold substrates modified with gold nanoparticles” (2006)WO2006/021091.
  5. Long, Y.-T., Li, C.-Z, Kraatz H. B. and Lee, J. S. “Electrochemical detection of DNA Binding”. (2006)US2006/0275786.
  6. JS Lee, H-B Kratz, Li Chenzhong, Long Yitao, "Nucleic acid mismatch detection“, (2006)CN1784497 A, PCT/CA2004/000332.
  7. B. Allain, Keith B. Male, J.H..Luong, R. Mandeville,C.-Z. Li, and C. Xiao “Method and apparatus for the detection of microorganisms” (2004)WO2005088287.
  8. C-Z. Li, Y.-T. Long, H.-B. Kraatz, J.S. Lee, “Electrochemical detection of DNA binding.”WO 2005/001122. Licensed to Adnavance Technologies, Inc.
  9. H-B. Kraatz, C.-Z. Li, Y.-T. Long, J.S. Lee, “Nucleic Acid Mismatch Detection”,CA2516647.
  10. S. Lee, H.-B. Kraatz, C.-Z. Li, Y.-T. Long, “Nucleic Acid Mismatch Detection.” WO 2004/079001EP1608775A0, Licensed to Adnavance Technologies, Inc.
Honors & Awards

In recognition of his work, Dr. Li has received several awards and honors;

  • The Kauffman Entrepreneurship Professor Award in 2009 and 2011.
  • 2012 International Resource Award from Indian National Dairy Institute.
  • The 2013 FIU Collage of Engineering and Computing (COC) Outstanding Faculty Award in Research. 
  • 2014 JSPS (Japan) Professor Fellowship Award.
  • 2014 Excellent Faculty Award in Research and Creative Activities.
  • 2016 Pioneer in Technology Development Award by the Society of Braining Mapping &Therapeutics and Brain Mapping Foundations.
  • 2016 Minority-Serving Institution Faculty Award in Cancer Research, by American Association for Cancer Research (AACR).


Book & Book Chapters
  1. 1.C.-Z. Li, R. Jung, Z-Z, Wu, A Special Issue on Frontiers in Neural Biosensing Technology, Journal of Neuroscience and Neurengineering,, American Scientific Publishers, 2013.
  2. E. Hondroulis, P. Shah, X. Zhu,C.-z. Li, Biosensing Devices for Toxicity Assessment of Nanomaterials, In the book of Bio-interactions of Nanomaterials. Ed..V.D. Sutariya, chapter 5, 117-125. Taylor&Francis Group. (2014)
  3. E. Hondroulis,J. Nelson,C.-z. Li, Biomarker analysis for nanotoxicology. In Ramesh Gupta, editors: Gupta - Biomarkers in Toxicology, Oxford: Academic Press, 2014 , pp. 689 - 696.(ISBN: 978-0-12-404630-6).
  4. E. Hondroulis, J. Nelson, C.-Z. Li, “Nanobioelectronics for Noninvasive Neuronal Therapy” in The Textbook of Nanoneuroscience and Nanoneurosurgery, , Eds. Babak Kateb, John D. Heiss, 527-534. CRC Press. (2013)
  5. E. Hondroulis,C.-Z. Li, “ Electrical Impedance Biosensors in Nanotoxicity Studies” in “Nanotoxicity: Methods and Protocols” in the series Methods in Molecular Biology , 2010, Eds Joshua J. Reineke, John Walker, Springer Science and Business Media, New York, USA.
  6. S. Alwarappan,C.-Z. Li, "Nanomaterials Incorporated Bioelectronics", in Wiley Encyclopedia of Industrial Biotechnology, Bioprocess, bioseperation and cell technology, Ed.Michael C. Flickinger, 2010, (ISBN: 978-0-471-79930-6), John Wiley & Sons
  7. A. McGoron,C.-Z. Li (co-Editor), W. Lin, IFMBE Proceedings (ISBN: 978-3-642-01696-7), Vol. 24 (2009), Springer, Heidelberg, Germany.
  8. C.-Z. Li (Editor), A. McGoron, Special Issue on Biomedical Engineering, American Journal of Biomedical Science, 2009, New World Publishing International, Inc.
  9. Andy. X. Sun,C-Z. Li“Carbon Nanotubes and Nanowires Based Biosensors” in "Smart Biosensor Technology", Editor George K. Knopf, CRC Press. Chapter 12, 291-333, (2006).
  10. C.-Z. Li, Y-T. Long, T. C. Sutherland, J.S. Lee and H.-B. Kraatz, “DNA Electronic Biosensors Based on DNA Self-Assembled Monolayer on Gold Electrodes”, in “The Frontiers of Biochip Technologies”, Editor Dr. Jing Cheng, Kluwer Academic Publishers, AshChapter 5, 270-287, (2005)
Peer Reviewed Jounral Papers
  1. F. Xu, Z. Mou, J. Geng, X. Zhang,C. Z. Li, Azo dye decolorization by a halotolerant exoelectrogenic decolorizer isolated from marine sediment , Chemosphere, 2016, 158, 30-36.
  2. T. Shu, L. Su, J. Wang,C.Z. Li, X. J. Zhang, Value of the Debris of Reduction Sculpture: Thiol Etching of Au Nanoclusters for Preparing Water-Soluble and Aggregation-Induced Emission-Active Au(I) Complexes as Phosphorescent Copper Ion Sensor ,Anal. Chem., 2016, 88, 6071-6077.
  3. X. Wu, X. Gong, W. Dong, J. Ma, J. Chao,C.Z. Li, L. Wang, C. Dong, A novel fluorescein-based colorimetric probe for Cu2+ detection, RSC Adv., 2016, 6, 59677-59683.
  4. M. Hong, L. Xu, F. Wang, Z. Geng, H. Li, H. Wang,C.Z. Li, A direct assay of carboxyl-containing small molecules by SALDI-MS on a AgNP/rGO-based nanoporous hybrid film, Analyst, 2016, 141,2712-2726.
  5. C.M. Yuede, H. Lee, J.L. Restivo, T.A. Davis, J.C. Hettinger, C.E. Wallace, K.L. Young, M.R. Hayne, G. Bu,C.-Z. Li, J.R. Cirrito, “Rapid in vivo Measurement of beta-amyloid Reveals Biphsic Clearance Kinetics in an Alzheimer’s Mouse Model”, the Journal of Experimental Medicine (IF:12.515), 2016,213 (2), 2132OIA84.
  6. P. Shah, X. Zhu, X, Zhang, J, He,C.-Z. Li, “Microelectromechanical System-Based Sensing Arrays for Comparative in Vitro Nanotoxicity Assessment at Single Cell and Small Cell-Population Using Electrochemical Impedance Spectroscopy”, ACS Applied Materials&Interfaces (IF:6.723), 2016,9,5804-5812.
  7. X. Li, J. Song, B.L. Chen, B. Wang, R. Li, H.M., Jiang, J.F. Liu,C.-Z. Li, “A label-free colorimetric assay for detection of c-Myc mRNA based on peptide nucleic acid and silver nanoparticles”, Science Bulletin, 2016, 61, 4, 276-281. (highlighted by,,
  8. Y.G. Yang, M. Hong, L. Xu, J. Cui, G. Chang, D. Li,C.-Z. Li, Organotin(IV) complexes derived from Schiff base N '-[(1E)-(2-hydroxy-3-methoxyphenyl)methylidene] pyridine-3-carbohydrazone: Synthesis, in vitro cytotoxicities and DNA/BSA interaction, J. Organometall. Chem.,2016, 804, 48-58.
  9. M. Hong, Y.G.Yang, C.Li, L.D. Xu, d.D. Li,C.-Z. Li, Study of the effect of molecular structure and alkyl groups bound with tin(IV) on their cytotoxicity of organotin(IV) 2-phenyl-4-selenazole carboxylates, RSC Advances (IF 3.8), 2015, 124, 102885-102894.
  10. C.-Z. Li, An insight into the cells’ glycans and lectin-glycosensing sites. Sci. Bulletin, 2016, 61, 2, 108-109.
  11. M. Nan, W.F., Niu, L. Fan, W.J. Lu, S.M. Shuang,C.-Z. Li, C. Dong, Indole-based pH probe with ratiometric fluorescence behavior for intracellular imaging, RSC Advances (IF 3.8), 2015, 121, 99739-99744.
  12. X. Dai, Y.C. Huang, J. Leichner, M., Nair, W.C. Lin,C.-Z. Li, Peptide modified polymer poly (glycerol- dodecanedioate co-fumarate) for efficient control of motor neuron differentiation,Biomedical Materials, 2015, 10(6): 065013.
  13. H. A. Badr, D. M.M. AlSadek, M. P. Mathew,C.-Z. Li, L. B. Djansugurova, K. J. Yarema, H. Ahmed, Lectin staining and Western blot data showing differential sialylation of nutrient-deprived cancer cells to sialic acid supplementation,Data in Brief, 2015, 5,481-488.
  14. H. A. Badr, D. M.M. AlSadek, M. P. Mathew,C.-Z. Li, L. B. Djansugurova, K. J. Yarema, H. Ahmed, Nutrient-deprived cancer cells preferentially use sialic acid to maintain cell surface glycosylation, Biomaterials, 2015, 70, 23-36.
  15. L. Yang, B. Wang, H. Qi, Q. Gao,C.-Z. Li and C. Zhang, Highly Sensitive Electrochemical Sensor for the Determination of 8-Hydroxy-2′-deoxyguanosine Incorporating SWCNTs-Nafion Composite Film, J. Sensors,
  16. H. Abe, K. Ino, C.-Z. Li, Y. Kanno, K. Y. Inoue, A. Suda, R. Kunikata, M. Matsudaira, Y.Takahashi,H. Shiku,T. Matsue, Electrochemical Imaging of Dopamine Release from Three-Dimensional-Cultured PC12 Cells Using Large-Scale Integration-Based Amperometric Sensors, Anal. Chem., 2015,87(12), pp 6364–6370.
  17. Z. Zhao, Z. Xing, M. Zhou, Y. Chen,C.-Z. Li, R, Wang, W. Xu, M. Ma, Functional analysis of synthetic DELLA domain peptides and bioactivegibberellin assay using surface plasmon resonance technology, Talanta, 2015, 144,502-509.
  18. E. Hondroulis, P. Shah, X.N, Zhu, C.-Z. Li, Eid. V.B. Sutariya, Y. Pathak, Biointeractions of Nanomaterials, 2015, 117-129.
  19. P. Shah, T. N. Narayanan,C.-Z. Li, S. Alwarappan, Probing the biocompatibility of MoS2 nanosheets by cytotoxicity assay and electrical impedance spectroscopy, Nanotechnology, 2015, 26, 315102.
  20. Y. Kanno, K. Ino, K.Y. Inoue, M.Sen, A. Suda, R. Kunikata, M. Matsudaira, H. Abe, C.-Z. Li, H. Shiku, T. Matsure, Feedback mode-based electrochemical imaging of conductivity and topography for large substrate surfaces using an LSI-based amperometric chip device with 400 sensors, J. Electroanal., Chem., 2015, 741, 109-113.
  21. S. Liu, M. Li, X. Yu, C.-Z. Li, H, Liu, Biomacromolecular logic gate, encoder/decoder and keypad lock based on DNA damage with electrochemiluminescence and electrochemical signals as outputs, Chem. Commun., 2015, 51, 13185-13188.
  22. P. Shah, Q. Yue, X. Zhu, F. Xu, H.-S. Wang, C.-Z. Li, PC12 cell integrated biosensing neuron devices for evaluating neuronal exocytosis function upon silver nanoparticles exposure, Sci. Chia Chem. 2015, 58,(10), 1600-1604.
  23. P. Zhang, Z. He, C. Wang, J. Chen, K. Zhao, X. Zhu,C.-Z. Li, Q. Min, J.J. Zhu, In Situ Amplification of Intracellular MicroRNA with MNAzyme Nanodevices for Multiplexed Imaging, Logic Operation, and Controlled Drug Release, ACS Nano, 2015, 9,1, 789-798.
  24. S. Liu, L. Wang, W. Lian, H. Liu, C.-Z. Li, Logic Gate System with Three Outputs and Three Inputs Based on Switchable Electrocatalysis of Glucose by Glucose Oxidase Entrapped in Chitosan Films, Chem. Asian J.,(IF: 3.935), 2015, 10, 225-230.
  25. T. Shu, L. Su, J. Wang, C.-Z. Li, X, Zhang. Chemical etching of bovine serum albumin-protected Au25 nanoclusters for label-free and separation-free detection of cysteamine. Biosensor & Bioelectronics. 2015 Apr 15; 66:155-161.
  26. Y. Yu, F. Zuo,C.-Z. Li, Mediator-assisted photocurrent extraction from the thylakoids, Electrochim Acta, 2014, 144, 263-367.
  27. Y. Yu, F. Zuo, C.-Z. Li, The Dependence of the Photocurrent on the Concentration of Electron Mediator (Para-Benzoquinone) in Thylakoids. Biophysical J., 2014, 2, 181A.
  28. A microwell pattern for C17.2 cell aggregate formation with concave cylindrical surface induced cell peeling, L.G. Zhang, D.H. Zhong, Y. Zhang,C.-Z. Li, W. S. KIsaalita, Z.-Z. Wu, Biomaterials, 2014, 35, 9423-9437.
  29. C. Liu, S. Alwarappan, Y. Zhang, H. Badr, J. J. Zhu, C.-Z. Li, "Live Cell Integrated SPR Biosensing Approach to Mimic the Regulation of Angiogenic Switch (VEGF-VEGFR) upon Anti-Cancer Drug Exposure", Analytical Chemistry, 2014, 86(15):7305-10.
  30. E. Hondroulis, C. Chen, C. Zhang, K. Ino, T. Matsue,C.-Z. Li, “Immuno Nanoparticles Integrated Electrical Control of Targeted Cancer Cell Development Using Whole Cell Bioelectronic Device”, Theranostics (IF: 7.806, cover page), 2014; 4(9):919-930.
  31. T. Xu, N. Scafa, L.-P. Xu, L. Su, C.-Z. Li, S. Zhou, Y. Liu, X. Zhang, Electrochemical Sensors for Nitric Oxide Detection in Biological Applications, Electroanalysis, 2014, 26, 449-468.
  32. X. Zhu, S. Ross, V. Urquidi, C. J Rosser, C. Zhang, C.-Z. Li, "Immuno strip based point-of-care testing for bladder cancer biomarkers detection", Chemical Sensors, 2014, 4,12.
  1. H. A. Badr, D. M.M. AlSadek, A.A. Darwish, A.I. ElSayed, B. O. Bekmanov, E. M. Khussainova, X. Zhang, W. C. S. Cho, L. B. Djansugurova, C.-z. Li, Lectin approaches for glycoproteomics in FDA-approved cancer biomarkers, Expert Review of Proteomics (IF 4.406), 2014, 11(2), 227-236.
  2. X. Zhu, P. Shah, S. Stoff, H. Liu, C.-z. Li, Paper electrode integrated lateral flow immunosensor for quantitative analysis of oxidative stress induced DNA damage, Analyst, 2014, 139 (11), 2850-2857.
  3. J. Chen, S. Sun, C.-Z. Li, Y.-G. Zhu, B. P. Rosen, Biosensor for Organoarsenical Herbicides and Growth Promoter, Environmental Science and Technology (IF, 5.257), 2014, 48 (2), 1141-1147.
  4. P. Shah, A. Kaushik, X. Zhu, C. Zhang, C.-Z. Li, Chip Based Single Cell Analysis for Nanotoxicity Assessment, Analyst (IF, 3.969), 2014, 139, 2088-2098. (Hot Article and are featuring on the Analyst blog).
  5. P. Shah, X. Zhu, C. Chen, Y. Hu, C.-Z. Li, Lab-on-Chip device for single cell manipulation and analysis, Biomedical Microdevices, 2014, 16(1), 35-41.\
  6. S. Alwarappan, M. Das, S. Mohapatra, C.-Z. Li, Peripheral Neural Devices: State-of-the-Art, Journal of Neuroscience and Neuroengineering, 2, 517-531 (2013).
  7. Y. Yu, F. Zuo, Li, C.-Z. Li, The peak effect of the photocurrent on the concentration of electron mediator (para-benzoquinone) in thylakoids, Electrochimica Acta (IF 3.642),. 2013, 113, 603-608.
  8. F.F. Chen, W. Chen, L.H., Hu, G. Chen, G, H.T. Miao, C.-Z. Li, J.J. Zhu, Highly dispersible PEGylated graphene/Au composites as gene delivery vector and potential cancer therapeutic agent, J. Mat. Chem. B , 2013, 1, 38, 4956-4962.
  9. E. Hondroulis, S. J. Melnick, X. Zhang, Z-Z. Wu, C.-Z. Li, Electrical Field Manipulation of Cancer Cell Behavior Monitored by Whole Cell Biosensing Device, Biomedical Microdevices, 2013. 15(4), 657-663.
  10. H. A. Badr, A. I. ElSayed, H. Ahmed, L. B. Djansugurova, C.-Z. Li, Preferential Lectin Binding of Cancer Cells upon Sialic Acid Treatment Under Nutrient Deprivation, Applied Biochemistry and Biotechnology, 2013, 171(4), 963-974.
  11. J. R. McKenzie, C. Zhang, C.-Z. Li, Deposition Strategies for Osmium/Enzyme Films on Gold Electrode Based Sensing Arrays, Electroanalysis, (IF2.52)2013, 25 (2), 341-344.
  12. H. Yang, Z. Li, X. Wei, R. Huang, H. Qi, Q. Guo, C.-Z. Li, C. Zhang, Detection and discrimination of alpha-fetoprotein with a label-free electrochemical impedance spectroscopy biosensor array based on lectin functionalized carbon nanotubes, Talanta (IF3.756), 2013,111,62-68.
  13. L. Su, T. Shu, Z. Wang, J. Cheng, F. Xue, C.-Z. Li, X.J. Zhang, Immobilization of bovine serum albumin-protected gold nanoclusters by using polyelectrolytes of opposite charges for the development of the reusable fluorescent Cu2+-sensor, Biosensors and Bioelectronics, 2013, 44, 16-20.
  14. L. Meng, A.Jiang, R. Chen, C.-Z. Li, L. Wang, Y. Qua, P. Wang, Y. Zhao, C. Chen,∗ Inhibitory effects of multiwall carbon nanotubes with high iron impurity on viability and neuronal differentiation in cultured PC12 cells, Toxicology (IF3.884), 2013, 8, 49-58.
  15. J.J., Yin, S. Sharma, S.P. Shumyak, Z.X. Wang, Z.W. Zhou, Y. Zhang, P. Guo, C.-Z. Li, J.R. Kanwar, T. Yang, S.S. Mohapatra, W. Liu, W. Duan, J.C. Wang, Q. Li, X. Zhang, J Tan, L. Jia, J. Liang, M.Q. Wei, X. Li, S.F. Zhou, “Synthesis and biological evaluation of novel folic acid receptor-targeted, β-cyclodextrin-based drug complexes for cancer treatment.”, PLoS One (IF3.54). 2013, 8(5), pp. e62289-1-e62289-20\
  16. D. Carvajal, R. Guduru, L. Lagos, Y. Katsenovich, C.-Z. Li, Assessment of the Resistance to Uranium (VI) Exposure by Arthrobacter sp. Isolated from Hanford Site Soil, Geomicrobiology Journal (IF 2.107), 2013, 30, 120-130.
  17. X. Zhu, E. Hondroulis, C.-Z. Li, Biosensing Approach for Rapid Genotoxicity and Cytotoxicity Assay upon Nanomaterial Exposure, Small (IF 8.407), 2013, 9, 1821-1830.
  18. Z.Z. Wu, Z.W. Wang, L.G.Zhang, Z.X. An, D.H. Zhong, Q. P. Huang, M.R. Luo, Y.J. Liao, L. Jin, C.-Z. Li, W. Kisalita, Responsiveness of voltage-gated calcium channels in SH-SY5Y human neuroblastoma cells on quasi-three-dimensional micropatterns formed with poly(l-lactic acid), Int’l J of Nanomed. (IF 4.424), 8,93-107, 2013.
  19. L. Meng , R. Chen , A. Jiang , L. Wang , P. Wang , C.-Z. Li , R. Bai , Y. Zhao , H. Autrup , C. Chen, Short Multiwall Carbon Nanotubes Promote Neuronal Differentiation of PC12 Cells via Up-Regulation of the Neurotrophin Signaling Pathway, Small (IF 8.407), 2013, 27;9(9-10):1786-98.
  20. P. Shah, X. Zhu, C.-Z. Li, Development of Paper-based Analytical Kit for Point of Care Testing, Expert Review of Molecular Diagnostics (IF 4.859), 13, 83-91, 2013.
  21. C. Liu, T. Lei, I. Kosuke, T. Matsue, N. Tao, C.Z. Li, Real-Time Monitoring Biomarker Expression of Carcinoma Cells by Surface Plasmon Resonance Biosensors, Chem.Comm, (IF 6.169 ), 2012, 48(84), 10389-10391.
  22. S. Alwarappan, K, Cisselll, S. Dixit, S. Mohapatra, C.-Z. Li, Chitosan-Modified Graphene Electrodes for DNA Mutation Analysis, J. Electroanal. Chem., (IF, 2.907),2012,689,69-72.
  23. G. Chen, J. Wang, C. Wu, C-Z., Li, H. Jiang, M. Wang, Photoelectrocatalytic oxidation of glutathione based on porous TiO2-Pt nano-whiskers, Langmuir, 2012, 28 (33), 12393-12399.
  24. C.Liu, C. Liu, V. Balsamo, D. Sun, B. Rosen, C.-Z. Li, A 3D Localized Surface Plasmon Resonance Biosensor for the Study of Trivalent Arsenic Binding to the ArsA ATPase . Biosensors and Bioelectronics (IF 5.483), 2012, 38 (1), 19-26.
  25. C.-Z. Li, H. Karadeniz, E. Canavar, A. Erdem, Electrochemical sensing of label free DNA hybridization related to breast cancer1gene at disposable sensor platforms modified with single walled carbon nanotubes, Electrochimica Acta (IF 3.642), 2012, 82, 137-142.
  26. S. Alwarappan, S. Boyapalle, A. Kumar, C.-Z. Li, S. Mohapatra, Comparative study of Single, Few and Multi-layered Graphene towards Enzyme Conjugation and Electrochemical Response, Journal of Physical Chemistry C (IF 4.522), 2012, 116, 6556-6559.
  27. S. Prabhulkar, H. Tian, X, Wang, C-Z. Li, Engineered Proteins: Redox properties and their applications, Antioxidants and Redox Signaling (IF 8.51), 2012,17(12), 1796-1822.
  28. D. Dickson , G. Liu, C.-Z. Li, G. Tachiev, Y. Cai, Dispersion and Stability of Bare Hematite Nanoparticles: Effect of Dispersion Tools, Nanoparticle Concentration, Humic Acid and Ionic Strength, Science of the Total Environment (IF 3.19), 2012,419, 170-177.
  29. L.-G. Zhang, Z.-Z. Wu, Z.-q. Song, Q.-p. Huang, Y.-j. Liao, C.-Z. Li, Fabrication of three-dimensional microwell patterns and their integration with C17.2 neural stem cells, Chinese Journal of Biomedical Engineering, in press.
  30. S. Prabhulkar, R. Piatyszek, J. R. Cirrito, Z-z. Wu, C.-Z. Li, Microbiosensor for Alzheimer’s Disease Diagnostics: Detection of Amyloid Beta Biomarkers, Journal of Neurochemistry (IF 4.480), 2012, 122, 374-381.
  31. S. Muhammad, S. B. Arshad, C.-Z. Li, B. Habib, Use of SPR Biosensor for the Study of Proteolytic Action of a Serine Protease Enzyme, American Journal of Biomedical Sciences, 2011, 3(4), 253-257.
  32. Z.-Z. Wu, M. Zhu, W. S. Kisaalita, L. Wang, Y.P. Zhao, Y. Lin, Q. Huang, Y. Liao, C.-Z. Li, Fabrication of Arrayed Topographic Substrates and Their Effects on the Electrobiophysical Properties of Neuronal Cells, Journal of Transduction Technology, 2011, 24, 467-474.
  33. C. Urbanek, S. Goodison, M. Chang, S. Porvasnik, N. Sakamoto, C.-Z. Li, C. Ketcham, S. Boehlein, C. J Rosser, Detection of antibodies directed at M. hyorhinis p37 in the serum of men with newly diagnosed prostate cancer, BMC Cancer (IF 2.74), 2011, 11, 233.
  34. E. Hondroulis, C.-Z. Li, Impedance based Nanotoxicity Assessment of Graphene Nanomaterials at the Cellular and Tissue Level, Analytical Letters (IF 1.344), 2011, 45, 272-282.
  35. C.-Z. Li, K. Vandernberg, S. Prabhulkar, X. Zhu, L. Schneper, K. Methee, C.J. Rosser, E. Almeide, Paper Based Point-of-Care Testing Disc for Multiplex Whole Cell Bacteria Analysis, Biosensors and Bioelectroncs (IF 5.483), 2011, 26, 4342-4348.
  36. Z. Zhang, A. J. McGoron, E. T. Crumpler, C.-Z. Li, Co-culture based blood-brain barrier in vitro model, a tissue engineering approach using immortalized cell lines for drug transport study, Applied Biochemistry and Biotechnology (IF 1.879), 2011, 163, 278-295.
  37. C. Liu and C.-Z. Li, Surface Engineering of Graphene-Enzyme Nano Composites for Miniaturized Biofuel Cell, IEEE Transactions on Nanotechnology (IF 2.15), 2011, 10 (1). 59-62.
  38. E. Hondroulis, C. Liu, C.-Z. Li, Whole cell based electrical impedance sensing approach for rapid nanotoxicity assay, Nanotechnology, 2010, 31, 315103.
  39. S. Alwarappan, C. Liu, A. Kumar, C.-Z. Li, Enzyme Doped Graphene Nanosheets for Enhanced Glucose Biosensing, J. Phys. Chem C, 2010, 114 (30), 12920-12924.
  40. R. Banerjee, Y. Katsenovich, L. Lagos, M. Senn, M. Naja, V. Balsamo, K.H. Pannell, C.-z. Li, Functional Magnetic Nanoshells Integrated Nanosensor for Trace Analysis of Environmental Uranium Contamination, Electrochimica Acta (2010), 2010, 55(27), 7897-7902.
  41. C.-Z. Li, R. Banerjee, X. Zhang, Y. Katsenovich, L. Lagos, “Nanomedicine: magnetic nanoparticles and their biomedical applications.”, Current Medicinal Chemistry, 2010, 17 (27), 3120-3141.
  42. Z. Zhang, A. Conway, A. Salamone, E. T. Crumpler, X. Zhang and C.-Z. Li, “Amphiphilic Copolymers for Liquid Bandage Application Studies”, Frontiers in Bioscience, E2, 1123-1133.
  43. Ning Zhao, Yuqing He, Xun Mao, Yuhan Sun, Xibao Zhang, Chen-zhong Li, Yuehe Lin, Guodong Liu, “Electrochemical assay of active prostate-specific antigen (PSA) using ferrocene-functionalized peptide probes”, Electrochem. Comm. 2010, 12 ,471–474.
  44. W. Chen, Y. Li, G. Yu, C.-Z. Li, S. Zhang, Z. Zhou, Z, Chen, “A Simple Approach to Realize Semiconductor―HalfMetal―Metal Transition in Boron Nitride Nanoribbons", J. Am. Chem. Soc., 2010, 132, 1699-1705.
  45. C. Liu, S. Alwarappan and C.-Z. Li, Design and Characterization of novel membraneless enzymatic biofuel cell based on graphene nanosheets, Biosensors and Bioelectronics, 2010, 7, 1829-1833.
  46. B. Chen, Y. Xiao, C. Liu, C.-Z. Li, F. Leng “DNA Linking Number Change Induced by Sequence-Specific DNA-Binding Proteins”, Nucleic Acids Research, 2010, 38(11), 3643-3654.
  47. S. Alwarappan, C.-Z. Li “Simultaneous detection of dopamine, ascorbic acid and uric acid at electrochemically activated carbon nanotube biosensors”, Nanomedicine, NBM, 2010, 6, 52-57.
  48. (cover page) C.-Z. Li, S. Alwarappan, W. Zhang, N. Scafa, X. Zhang “Metallo Protoporphyrin Functionalized Microelectrodes for Electrocatalytic Sensing of Nitric Oxide”, Am. J. Biomed. Sci., 2009, 1, 274 – 282.
  49. S. Prabhulkar, S. Alwarappan, C.-z. Li “Amperometric Micro Immunosensor for the Detection of Tumor Biomarker based on Direct Electrochemistry of Ferrocene” Biosensors & Bioeletronics, 2009, 24, 3524-3530.
  50. C.-Z, Li, I. Taniguchi, A. Mulchandani, “Redox Properties of Engineered Ruthenium Myoglobin”, Bioelectrochemistry, 2009, 75, 182-188.
  51. C.-Z. Li, G. Liu, S. Prabhulkar, “Comparison of Kinetics of Hemoglobin Electron Transfer in Solution and immobilized on Electrode Surface” Am. J. Biomed. Sci., 2009, 1, 303 – 311.
  52. S. Alwarappan, A. Erdem, C. Liu, C.-Z. Li “Probing the electrochemical properties of graphene nanosheets for biosensing application”, J. Phys. Chem C, 2009, 113, 8853-8857.
  53. S. Alwarappan, S. Prabhulkar, A. Durygin and C.-Z. Li “The effect of electrochemical pretreatment on the sensing performance of single walled carbon nanotubes”, J. Nanosci. Nanotech, 2009, 9, 2991-2996.
  54. C.-H. Chuang , C.-Z. Li, C.-C. Yeh , Y.-M.Hsu “Electrorotation of HL-60 Cells Uptake of Metal and Dielectric Nanoparticles in a Stationary AC Electric Field” IEEE Rev. Adv. M/NEMS, 2008, 938-942. Art. no. 4484476, pp. 938-942.
  55. C.-Z.Li, W-B. Choi, Cheng-Hsin Chuang “Enhancement of Photocurrents by Finite-Sized SWNT Based Thin Films” Electrochim. Acta, 2008, 54, 821-828.
  56. C.-Z. Li, K.B. Male, S.Hropovic, J.H.T. Luong “Fluorescence Properties of Gold Nanorods and Their Application for DNA Analysis”, J. Chem. Soc. Chem. Comm. 31, 2005, 3924-3926.
  57. B. Liu, C.-Z. Li, H-B. Kraatz and A.J. Bard “Scanning Electrochemical Microscopy: Studies of Self-Assembled Monolayers of DNA in Absence and Presence of Metal Ions”, J. Phys. Chem. B, 109, 2005, 5193-5198.
  58. C.-Z. Li, Y, Liu, J.H.T. Luong “Impedance Sensing of DNA Binding Drugs using Gold Substrates Modified with Gold Nanoparticles”, Anal. Chem. 77, 2005. 478-485.
  59. Y-T. Long, C.-Z. Li, T. C. Sutherland, H-B. Kraatz and J.S. Lee “Electrochemical Detection of Single-Nucleotide Mismatches: Application of M-DNA” Anal. Chem. 76, 2004, 4059-4065.
  60. C.-Z. Li, Y.-T. Long, J.S. Lee and H-B. Kraatz “Protein-DNA Interaction: Impedance Study of MutS Binding to DNA Mismatches ” J. Chem. Soc. Chem. Comm. 5, 2004, 574-575.
  61. Bediako-Amoa, T.C. Sutherland, C.-Z. Li, R. Silerova, and H.B. Kraatz, "Electrochemical and Surface Study of Ferrocenoyl Oligopeptides", J. Phys. Chem. B,108, 2004, 704-714.
  62. Y-T. Long, C.-Z. Li, Todd C. Sutherland, M’hamed Chahma, H-B. Kraatz and J.S. Lee “A Comparison of Electron Transfer Rates of Ferrocenoyl Linked DNA”, J. Am. Chem. Soc, 125 (29), 2003, 8724-8725
  63. C.-Z. Li, Y-T. Long, J.S. Lee and H-B. Kraatz “Electrochemical Investigations of M-DNA Self-Assembled Monolayers on Gold Electrodes” J. Phys. Chem. B, 107, 2003, 2291-2296.
  64. Y-T. Long, C.-Z. Li, H-B. Kraatz and J.S. Lee “AC Impedance Spectroscopy of Native DNA and M-DNA” Biophys. J., 84, 2003, 3218-3225.
  65. S. Wettig, C.-Z. Li, Y-T. Long, H-B. Kraatz and J.S. Lee “M-DNA: A conductive form of duplex DNA with applications in nanoelectronics and biosensing” Anal. Sci. 19(1) 2003, 23-26.
  66. C.-Z. Li, K. Nishiyama and I. Taniguchi “Electrochemical and Spectroelectrochemical Studies on Cobalt Myoglobin” Electrochim. Acta. 45(2000): 2883-2888.
  67. Taniguchi, C.-Z. Li, M. Ishida and Q. Yao “Electrochemical and Spectroelectrochemical Properties of Manganese Reconstituted Myoglobin”. J. Electroanal. Chem. 460 (1999) 245-250Q.
  68. Yao, C.-Z. Li, F. M. Hawkridge, K. Nishiyama and I. Taniguchi “Effect of Hydrophilicity of the Indium Oxide Electrode Surface on Hemoglobin Electrochemistry” Review of Polarography, Vol. 40, No. 3/6, 76 (1994).
Publications in Academic Proceeedings
  1. P. Shah, X. Zhu,C.-Z. Li, “Development of a Cell-Chip Array for Single Cell Capturing Using Dielectrophoresis”, 29th Southern Biomedical Engineering Conference (Sbec 2013) (ISI indexed),, 2013, 59-60.
  2. X.Zhu, P. Shah, C.-Z. Li, “Paper-based Immunosensor for Oxidative DNA Damage Biomarker Detection”, 29th Southern Biomedical Engineering Conference (Sbec 2013) (ISI indexed),, 2013, P 125-126.
  3. R. Guduru, D. Carvajal, Y. Katsenovich, L. Lagos, D. McDaniel, C.-Z. Li, “Investigation of the Effect of Uranium on Microbial Surfaces using Atomic Force Microscopy”, WM2011 Conference Proceedings, Phoenix. 2011, 24-35.
  4. R. Banerjee, D. Carvajal, Y. Katsenovich, L. Lagos, B. Tansel, C.-Z. Li, “Response of Hanford Site Soil Arthrobacter Isolates to Uranium Contamination”, The 36th annual Waste Management Conference, WM2010 Conference Proceedings, Phoenix. 2010, 24-35.
  5. S. Prabhulkar, S. Alwarrapan, G.M. Naja, and C.-Z.Li, “Electrochemical Immunosensor for the Direct, Reagentless Detection of Tumor Biomarkers” IFMBE Proceedings, 2009, 189-191.
  6. E. Hondroulis, C.-Z. Li, “Development of Cell Impedance Based Sensing System for the Nanotoxicity Assay” IFMBE Proceedings, 2009, 113-116.
  7. S. Prabhulkar, C.-Z. Li, “Electrical Immuno Nanosensor for Breast Cancer Biomarker Assay”, IEEE, ICBBE 2009 (EI indexed), ISBN: 9781414429028, 2009, 98-102.
  8. R. Banerjee, Y. Katsenovich, G.M. Naja, and C.-Z. Li, “Using Nano-sensors in Environmental Radionuclide Monitoring” IFMBE Proceedings, 2009, 191-197.
  9. Z. Zhang, E. Crumpler, and C.-Z. Li, “Blood-Brain Barrier In Vitro Model Utilizing Immortalized Cell Lines” IFMBE Proceedings, 2009, 251-253.
  10. S. Prabhulkar, S. Alwarappan, C.-Z. Li, “Needel-Like Implantable Nanosensor of the Detection of Tumor Biomarkers” Biomedical Engineering Recent Developments, Medical & Engineering Publishers, Inc (Sunshine, MD). ISBN: 9781930636071), 2008, 219-221.
  11. E.Abu-Irhayem,Y.-T.Long,T.Sutherland,C.-Z.Li,H.-B.Kraatz,J.S.Lee,“Electrochemical detection of single-nucleotide mismatches: Application of M-DNA”, 2005 NSTI Nanotech 2005 Technical Proceedings, Nano Science and Technology Institute, ISBN: 0976798506, 2005, 430-433.
  12. C.-Z. Li, J. Lee “Formation and characterization of Self-assembled DNA monolayer on microelectrode” Biosensors Proceedings, Kyoto, 2002, 256-260.
  13. C.-Z. Li, Y. Long, J. Lee “Electric DNA Biosensors Based on M-DNA Self-Assembled Monolayer on Gold Micro Electrode Arrays”, Proceeding of International Forum on Biochip Technologies, Beijing, 2002, 142-146.
  14. S. Prabhulkar, S. Alwarappan and C.-Z. Li “Needel-Like Implantable Nanosensor of the Detection of Tumor Biomarkers” Biomedical Engineering Developments, 2008, 219-221.
  15. C.-Z. Li, J. Lee “Formation and characterization of Self-assembled DNA monolayer on microelectrode” Biosensors 2002, 256-260.
  16. Z. Li, Y. Long, J. Lee “Electric DNA Biosensors Based on M-DNA Self-Assembled Monolayer on Gold Micro Electrode Arrays”, Proceeding of International Forum on Biochip Technologies 2002, 142-146.


Journal of Human on Chip Research Studies