William Wang
William Wang
Associate Professor

Department of Cardiology
University of Queensland


 Bachelor of Medicine  2000  University of Sydney
   Master of Medicine    2000    University of Sydney
   Doctor of Philosophy (PhD)    2004    University of Cambridge, UK




Research Interest

I have been involved with medical research since 1995 and conducted a variety of clinical, imaging, genetic and biostatical projects. I aim to combine cardiovascular imaging with advances in genomics to better understand cardiovascular pathophysiology and influence clinical medicine.

Professional Activities:



  1. Gillinder L, Goo SY, Cowin G, Strudwick M, Van Der Geest RH, Wang WYS, Arnold CT Ng. Quantification of Intramyocardial Metabolites by Proton Magnetic Resonance Spectroscopy. Frontiers in Cardiovascular Medicine 2015; DOI: 10.3389/fcvm.2015.00024.
  2. Singbal Y, Vollbon W, Huynh LT, Wang WYS, Ng ACT, Wahi S. Exploring the role of non-invasive tricuspid dP/dt as a marker of right ventricular function. Echocardiography 2015;32:1347–1351.
  3. Musameh MD, Wang WYS, Nelson CP, Lluís-Ganella C, Debiec R, Subirana I, Elosua R, Balmforth AJ, Ball SG, Hall AS, Kathiresan S, Thompson JR, Lucas G, Samani NJ, Tomaszewski M. Analysis of gene-gene interactions among common variants in candidate cardiovascular genes in coronary artery disease. PLOS One 2015; DOI: 10.1371/journal.pone.0117684.
  4. Tsai JPJ, Tian J, Wang WYS, Ng ACT. Glycated hemoglobin versus fasting plasma glucose as a predictor of left ventricular dysfunction after ST-elevation myocardial infarction. Canadian Journal of Cardiology 2015; 31: 44-49.
  5. Salamonsen MR, Lo AK, Ng ACT, Bashirzadeh F, Wang WYS, Fielding DIK. Novel use of pleural ultrasound can identify malignant entrapped lung prior to effusion. Chest 2014; 146: 1286-1293.
  6. Harrop DL, *Wang WYS, *Ng ACT. Pathophysiology and imaging techniques of diabetic heart disease. European Medical Journal Diabetes 2014; 2: 88-98 (*equal contributors).
  7. Butterly S, Indrajith M, Garrahy P, Ng ACT, Gould PA, Wang WYS. Stress-induced takotsubo cardiomyopathy in survivors of the 2011 Queensland floods. Medical Journal of Australia 2013; 198: 109-110. 2
  8. Chow V, Wang W, Wilson M, Yiannikas J. Thrombus in transit within a patent foramen ovale: an argument for consideration of prophylactic closure? Journal of Clinical Ultrasound 2012; 40: 115-118.
  9. Tomaszewski M, Charchar, FJ, Nelson CP, Barnes T, Denniff M, Kaiser M, Debiec R, Christofidou P, Rafelt S, van der Harst P, Wang WYS, Maric C, Zukowska- Szczechowska, E, Samani NJ. Pathway analysis shows association between FGFBP1 and hypertension.
  10. Journal of the American Society of Nephrology 2011; 22: 947-955.

  11. Kaess BM, Barnes TA, Stark K, Charchar FJ, Waterworth D, Song K, Wang WYS, Vollenweider P, Waeber G, Mooser V, Zukowska-Szczechowska E, Samani NJ, Hengstenberg C, Tomaszewski M. FGF21 signalling pathway and metabolic traits - genetic association analysis. European Journal of Human Genetics 2010; 18: 1344-1348.
  12. Tomaszewski M, Charchar FJ, Lynch MD, Padmanabhan S, Wang WYS, Miller WH, Grzeszczak W, Maric C, Zukowska-Szczechowska E, Dominiczak AF. Fibroblast growth factor 1 gene and hypertension - from the quantitative trait locus to positional analysis. Circulation 2007; 116: 1915-1924.
  13. Speirs HJL, Wang WYS, Benjafield AV, Morris BJ. No association with hypertension of CLCNKB and TNFRSF1B polymorphisms at a hypertension locus on chromosome 1p36. Journal of Hypertension 2005; 23: 1491-1496.
  14. *Benjafield AV, *Wang WYS, Speirs HJ, Morris BJ. Genome-Wide Scan for Hypertension in Sydney Sibships: The GENIHUSS Study. American Journal of Hypertension 2005; 18: 828-832 (*equal contributors).
  15. Payne F, Smyth DJ, Pask R, Cooper, JD, Masters J, Wang WYS, Godfrey LM, Bowden G, Szeszko J, Smink LJ, Lam AC, Burren O, Walker NM, Nutland S, Rance H, Undlien DE, Ronningen KS, Guja C, Ionescu-Tirgoviste C, Todd JA, Twells RC. No evidence for association of the TATA-box binding protein glutamine repeat sequence or the flanking chromosome 6q27 region with type 1 diabetes. Biochemical Biophysical Research Communications 2005; 331: 435-441.
  16. Wang WYS, Barratt BJ, Clayton DG, Todd JA. Genome-wide association studies: theoretical and practical concerns. Nature Reviews Genetics 2005; 6; 109-118.
  17. Tomaszewski M, Charchar FJ, Lacka B, Pesonen U, Wang WYS, Zukowska-Szczechowska E, Grzeszczak W, Dominiczak AF. Epistatic interaction between β2-adrenergic receptor and neuropeptide Y genes influences LDL–cholesterol in hypertension. Hypertension 2004; 44: 689-694.
  18. Benjafield AV, Wang WYS, Morris BJ. No association of ACE2 polymorphisms with essential hypertension. American Journal of Hypertension 2004; 17: 624-628.
  19. Speirs HJL, Katyka K, Kumara NN, Benjafield AV, Wang WYS, Morris BJ. Association of G-protein-coupled receptor kinase 4, but not HSD3B1 or PTP1B polymorphisms with essential hypertension. Journal of Hypertension 2004; 22: 931-936. 3 William WangCurriculum VitaeSeptember 2015
  20. *Marguerat S, *Wang WYS, Todd JA, Conrad B. Association of Human Endogenous Retrovirus K-18 Polymorphisms with Type 1 Diabetes. Diabetes 2004; 53: 852-854 (*equal contributors).
  21. Wang WYS, Todd JA. The usefulness of different density SNP maps for disease association studies of common variants. Human Molecular Genetics 2003; 12: 3145-3149.
  22. Meats A, Pike N, An X, Raphael K, Wang WYS. The effects of selection for early (day) and late (dusk) mating lines of hybrids of Bactrocera tryoni and Bactrocera neohumeralis. Genetica 2003; 119: 283-293.
  23. Benjafield AV, Iwai N, Ishikawa K, Wang WYS, Morris BJ. Overweight, but not Hypertension, is Associated with SAH Polymorphisms in Caucasians with Essential Hypertension. Hypertension Research 2003; 26: 591-595.
  24. Kumar NN, Benjafield AV, Lin RCY, Wang WYS, Stowasser M, Morris BJ. Haplotype analysis of aldosterone synthase gene (CYP11B2) polymorphisms shows association with essential hypertension. Journal of Hypertension 2003; 21: 1331-1337.
  25. Twells RCJ, Mein CA, Phillips MS, Hess JF, Veijola R, Gilbey M, Bright M, Metzker M, Lie BA, Kingsnorth A, Gregory E, Nakagawa Y, Snook H, Wang WYS, Masters J, Johnson G, Eaves I, Howson J, Clayton D, Cordell HJ, Nutland S, Rance H, Carr P, Todd JA. Haplotype Structure, LD Blocks, and Uneven Recombination Within the LRP5 Gene. Genome Research 2003; 13:845-855.
  26. Pike N, Wang WYS, Meats AW. The likely fate of hybrids of Bactrocera tryoni and Bactrocera neohumeralis. Heredity 2003; 90: 365-370.
  27. Wang WYS, Cordell HJ, Todd JA. Association Mapping of Complex Diseases in Linked Regions: Estimation of Genetic Effects and Feasibility of Testing Rare Variants. Genetic Epidemiology 2003; 24:36-43.
  28. Tomaszewski M, Lacka B, Charchar FJ, Wang WYS, Brain NJR, Padmanabahn S, Clark JS, Anderson NH, Edwards HV, Zukowska-Szczechowska E, Grzeszczak W, Dominiczak AF. Essential hypertension and beta(2)-adrenergic receptor gene linkage and association analysis. Hypertension 2002; 40:286-91.
  29. Medley TL, Cole TJ, Gatzka CD, Wang WYS, Dart AM, Kingwell BA. Fibrillin-1 genotype is associated with aortic stiffness and disease severity in patients with coronary artery disease. Circulation 2002; 105:810-815.
  30. Dahlman I, Eaves IA, Kosoy R, Morrison VA, Heward J, Gough SC, Allahabadia A, Franklyn JA, Tuomilehto J, Tuomilehto-Wolf E, Cucca F, Guja C, Ionescu-Tirgoviste C, Stevens H, Carr P, Nutland S, McKinney P, Shield JP, Wang W, Cordell HJ, Walker N, Todd JA, Concannon P. Parameters for reliable results in genetic association studies in common disease. Nature Genetics 2002; 30:149-50.
  31. *Glenn CL, *Wang WYS, Benjafield AV, Morris BJ. Linkage and association of tumor necrosis factor receptor 2 locus with hypertension, hypercholesterolemia and plasma shed receptor. Human Molecular Genetics 2000; 9:1943-1949 (*equal contributors).
  32. Lin RC, Wang WYS, Morris BJ. Association and linkage analyses of glucocorticoid receptor gene markers in essential hypertension. Hypertension 1999; 34: 1186-1192.
  33. Lin RC, Wang WYS, Morris BJ. High penetrance, overweight, and glucocorticoid receptor variant: case-control study. British Medical Journal 1999; 319: 1337-1338.
  34. Wang WYS, Glenn CL, Zhang W, Benjafield AV, Nyholt DR, Morris BJ. Exclusion of angiotensinogen gene in molecular basis of human hypertension: sibpair linkage and association analyses in Australian Anglo-Caucasians. American Journal of Medical Genetics 1999; 87: 53-60.
  35. Wang WYS, Adams DJ, Glenn CL, Morris BJ. The Gly460Trp variant of -adducin is not associated with hypertension in Australian Anglo-Caucasians. American Journal of Hypertension 1999; 12: 632-636.
  36. Glenn CL, Wang WYS, Morris BJ. Different frequencies of inducible nitric oxide synthase genotypes in older essential hypertensives. Hypertension 1999; 33: 927-932.
  37. Wang WYS, Zee RY, Morris BJ. Association of angiotensin II type 1 receptor gene polymorphism with essential hypertension. Clinical Genetics 1997; 51:31-4.


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