Peifeng Li
Peifeng Li

Institute for Translational Medicine
Qingdao University


M. S 1986-1989 Hebei Medical College
MD, Ph. D 1990-1993 Chinese Academy of Medical Science



Dr. Peifeng Li is currently a Professor of Medicine and Dean of Institute for Translational Medicine at Qingdao University, China. Dr. Li once served as Medical Researcher at Max-Delbruck Center for Molecular Medicine in Germany for ten years. He was elected to the “Hundred-Talent Program (Chinese Academy of Sciences)”, China. He has served as a reviewer for many international foundations. He is serving as an editor for several journals like Dataset Papers in Biology, Journal of Clinical and Experimental Cardiology, Journal of Cardiology and Therapy, and Journal of Geriatric Cardiology. He is an associate editor for Cardiovascular Regenerative Medicine.

Research Interest

Dr. Li has published over 80 articles in journals such as Molecular Cell, EMBO Journal, Nature Medicine, Nature Communication, Circulation, Circulation Research, PNAS. Based on his academic contributions, he has been honored with several prestigious accolades awards. His current research focuses include cardiovascular apoptosis and necrosis, non-coding RNA in heart diseases, and cardiac regeneration.

Professional Activities:



  1. Li PF, Zhang B, Li W, Ma X. Observation of mimetic aging action of free radicals on the cultured neurons. Chinese Journal of Pharmacology and Toxicology, 1992;6:60-63
  2. Li PF*, Fang Y, Li Y. Effect of Ascorbate-Fe(III) and Hydrogen Peroxide on the Immunological Property of Cu,Zn-SOD, Medical Science Research, 1993;21:521-524 (*Corresponding author)
  3. Li PF*, Fang Y, Lu X. Oxidative Modification of Bovine Erythrocyte Superoxide Dismutase by Hydrogen Peroxide and Ascorbate-Fe(III), Biochemistry and Molecular Biology International, 1993;29:929-937 (*Corresponding author)
  4. Li PF, Dietz R, von Harsdorf R. Reactive Oxygen Species Induce Apoptosis of Vascular Smooth Muscle Cells. FEBS Letters, 1997;404:249-252
  5. Li PF, Dietz R, von Harsdorf R. Differential effect of hydrogen peroxide and superoxide anion on apoptosis and proliferation of vascular smooth muscle cells. Circulation. 1997;96:3602-3609
  6. Li PF, Dietz R, von Harsdorf R. Superoxide induces apoptosis in cardiomyocytes, but proliferation and expression of transforming growth factor-b in cardiac fibroblasts. FEBS Lett. 1999;448:206-210
  7. von Harsdorf R, Li PF, Dietz R. Signaling pathways in reactive oxygen species-induced cardiomyocyte apoptosis. Circulation. 1999;99:2934-2941
  8. Li PF, Maasch C, Haller H, Dietz R, von Harsdorf R. Requirement for protein kinase C in reactive oxygen species-induced apoptosis of vascular smooth muscle cells. Circulation, 1999;100:967-973
  9. Li PF, Dietz R, von Harsdorf R. p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2. EMBO Journal, 1999;18:6027-6036
  10. Mehrhof FB, Muller FU, Bergmann MW, Li PF, Wang Y, Schmitz W, Dietz R, von Harsdorf R. In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires phosphatidylinositol-3-OH-kinase-dependent and mitogen-activated protein kinase-dependent activation of the transcription factor cAMP response element-binding protein. Circulation, 2001;104:2088-9204
  11. Li PF, Li J, Muller EC, Otto A, Dietz R, von Harsdorf R. Phosphorylation by protein kinase CK2: A signaling switch for the caspase inhibiting protein ARC. Molecular Cell, 2002;10:247-258
  12. Li J, Li PF, Dietz R, von Harsdorf R. Intracellular superoxide induces apoptosis in VSMCs: role of mitochondrial membrane potential, cytochrome c and caspases. Apoptosis  2002;6:511-517
  13. Donath S#, Li PF#, Willenbockel C, Al-Saadi N, Gross V, Willnow T, Bader M, Martin U, Bauersachs J, Wollert KC, Dietz R, von Harsdorf R. Apoptosis repressor with caspase recruitment domain is required for cardioprotection in response to biomechanical and ischemic stress. Circulation, 2006;113:1203-1212  (# authors contributed equally to this work)
  14. Li YZ, Lu DY, Tan WQ, Wang JX, Li PF*. p53 initiates apoptosis by transcriptionally targeting the anti-apoptotic protein ARC. Molecular and Cellular Biology. 2008;28:564-574. (*Corresponding author)
  15. Murtaza I, Wang HX, Feng X, Alenina N, Bader M, Prabhakar BS, Li PF*. Downregulation of catalase and oxidative modification of protein kinase CK2 lead to the failure of apoptosis repressor with caspase recruitment domain to inhibit cardiomyocyte hypertrophy. J Biol Chem. 2008;283:5996-6004. (*Corresponding author)
  16. Tan WQ, Wang K, Lv DY, Li PF*. Foxo3a inhibits cardiomyocyte hypertrophy through transactivating catalase. J Biol Chem. 2008;283:29730-29739 (*Corresponding author)
  17. Tan WQ, Wang JX, Lin ZQ, Li YR, Lin Y, Li PF*. Novel Cardiac Apoptotic Pathway: the Dephosphorylation of Apoptosis Repressor with Caspase Recruitment Domain by Calcineurin. Circulation. 2008;118:2268-2276. (*Corresponding author)
  18. Wang J, Li Q, Li PF*. Apoptosis repressor with caspase recruitment domain contributes to chemotherapy resistance by abolishing mitochondrial fission mediated by dynamin-related protein-1. Cancer Research. 2009;69:492-500. (*Corresponding author)
  19. An J#, Li PF#, Li J, Dietz R, Donath S. ARC is a critical cardiomyocyte survival switch in doxorubicin cardiotoxicity. Journal of Molecular Medicine, 2009;87:401-410. (# authors contributed equally to this work)
  20. Lin ZQ, Murtaza I, Wang K, Jiao JQ, Gao J, Li PF*. miR-23a functions downstream of NFATc3 to regulate cardiac hypertrophy. Proc Natl Acad Sci USA. 2009;106:12103-12108. (*Corresponding author)
  21. Kalsotra A, Wang K, Li PF, Cooper TA. MicroRNAs coordinate an alternative splicing network during mouse postnatal heart. Genes & Development. 2010;24:653-8.
  22. Wang K, Long B, Zhou J, Li PF*. miR-9 and NFATc3 regulate myocardin in cardiac hypertrophy. Journal of Biological Chemistry. 2010;285:11903-12. (*Corresponding author)
  23. Wang K, Li PF*. Foxo3a regulates apoptosis by negatively targeting miR-21. J Biol Chem. 2010;285:16958-66. (*Corresponding author).
  24. Li J, Zhou J, Li Y, Qin D, Li PF*. Mitochondrial fission controls DNA fragmentation by regulating endonuclease G. Free Radic Biol Med. 2010;49:622-31. (*Corresponding author)
  25. Li J, Li Y, Qin D, von Harsdorf R, Li PF*. Mitochondrial fission leads to Smac/DIABLO release quenched by ARC. Apoptosis. 2010;15:1187-96. (*Corresponding author)
  26. Li PF, Jayarama S, Ganesh L, Mordi D, Carr R, Kanteti P, Hay N, Prabhakar BS. Akt-phosphorylated mitogen-activated kinase-activating death domain protein (MADD) inhibits TRAIL-induced apoptosis by blocking Fas-associated death domain (FADD) association with death receptor 4. J Biol Chem. 2010;285:22713-22.
  27. Li J, Donath S, Li Y, Qin D, Prabhakar BS, Li PF*. miR-30 regulates mitochondrial fission through targeting p53 and the dynamin-related protein-1 pathway. PLoS Genetics. 2010;6:e1000795. (*Corresponding author)
  28. Li PF. microRNAs in cardiac apoptosis. Journal of Cardiovascular Translational Research. 2010;3:219-24. (review)
  29. Ding SL, Zhou LY, Li PF*. MicroRNAs in cardiac hypertrophy: angels or devils. Wiley Interdisciplinary Review-RNA. 2011;2:124-134. (*Corresponding author) (review)
  30. Wang JX, Jiao JQ, Li Q, Long B, Wang K, Liu JP, Li YR, Li PF*. miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1. Nature Medicine. 2011;17:71-78. (*Corresponding author)
  31. Wang K, Lin ZQ, Long B, Li JH, Zhou J, Li PF*. Cardiac hypertrophy is positively regulated by miR-23a. J Biol Chem. 2012;287:589-599.  (*Corresponding author)
  32. Li PF, Jiao J, Gao G, Prabhakar BS. MicroRNAs control mitochondrial activity. Journal of Cellular Biochemistry. 2012;113:1104-10. (review)
  33. Wang K, Long B, Jiao  J, Wang J, Liu JP, LI Q, Li PF*. miR-484 regulates mitochondrial network through targeting Fis1. Nature Communication, 2012, 3:781. doi: 10.1038/ncomms1770. (*Corresponding author)
  34. Li Q, Zhou LY, Gao GF, Jian JQ, Li PF*. Mitochondrial network in the heart. Protein Cell. 2012;3:410-8. (*Corresponding author)
  35. Zhou LY, Liu JP, Wang K, Gao J, Ding SL, Jiao JQ, Li PF*. Mitochondrial function in cardiac hypertrophy. International Journal of Cardiology. 2012, in press (*Corresponding author)
  36. Turner A,  Li LC, Pilli T, Qian L,  Wiley EL, Setty S, Christov K, Ganesh L, Maker A, Li PF, Kanteti P, Gupta T, Prabhakar BS. MADD knock-down enhances doxorubicin and TRAIL induced poptosis in breast cancer cells, PLoS One, 2013, 2013;8(2):e56817.
  37. Lu D, Liu J, Jiao J, Long B, Li Q, Tan W, Li PF*. Transcription factor Foxo3a prevents apoptosis by regulating calcium through the apoptosis repressor with caspase recruitment domain. J Biol Chem. 2013, 288:8491-8504. (*Corresponding author)
  38. Wang K, Liu F, Zhou LY, Ding SL, Long B, Liu CY, Sun T, Fan YY, Sun L, Li PF*. miR-874 regulates myocardial necrosis by targeting caspase-8. Cell Death and Disease (2013) 4,doi:10.1038/cddis.2013.233 (*Corresponding author)
  39. Long B, Wang K, Li N, Murtaza I, Xiao JY, Fan YY, Liu CY, Li PF*. Free Radic Biol Med. 2013;65C:371-379. (*Corresponding author)
  40. Ding SL, Wang JX, Jiao JQ, Tu X, Wang Q, Liu F, Li Q, Gao J, Zhou QY, Gu DF, Li PF*. A pre-miR-149 genetic variation affects miR-149 maturation and its ability to regulate Puma in apoptosis. J Biol Chem. 2013;288:26865-77s. (*Corresponding author)
  41. Murtaza I, Wang HX, Mushtaq S, Javed Q, Li PF. Interplay of phosphorylated apoptosis repressor with CARD, casein kinase-2 and reactive oxygen species in regulating endothelin-1-induced cardiomyocyte hypertrophy. Iran J Basic Med Sci. 2013;16:928-35.
  42. Jayarama S, Li LC, Ganesh L, Mardi D, Kanteti P, Hay N, Li PF, Prabhakar BS. MADD is a downstream target of PTEN in triggering apoptosis. J Cell Biochem. 2014;115:261-70.
  43. Wang K, Liu F, Zhou LY, Long B, Yuan SM, Wang Y, Liu CY, Sun T, Zhang XJ, Li PF*. A long noncoding RNA, CHRF regulates cardiac hypertrophy by targeting miR-489. Circulation Research, 2014, in press. (*Corresponding author)
  44. Li J, Li Y, Jiao J, Wang J, Li Y, Qin D, Li PF*. Mitofusin 1 is negatively regulated by miR-140 in cardiomyocyte apoptosis, Molecular and Cellular Biology. 2014, in press. (*Corresponding author)
  45. Li Q, Wang JX, He YQ, Feng C, Sheng JQ, Li PF*. MicroRNA-185 regulates chemotherapeutic sensitivity in gastric cancer through targeting apoptosis repressor with caspase recruitment domain. Cell Death & Diseases. 2014; in press. (*Corresponding author)
  46. Long B, Ding S, Liu F, Zhou LY, An T, Donath S, Wang K, Li PF*. Autophagic program is regulated by miR-325. Cell Death and Differentiation. 2014; in press. (*Corresponding author)
  47. Wang K, Long B, Zhou LY, Liu F, Zhou QY, Liu CY, Fan YY, Li PF*. CARL lncRNA inhibits anoxia-induced mitochondrial fission and apoptosis in cardiomyocytes by impairing miR-539-dependent PHB2 downregulation. Nature Communication. 2014 Apr 7;5:3596. doi: 10.1038/ncomms4596. (*Corresponding author)
  48. Liu F, Li N, Long B, Fan YY, Liu CY, Zhou QY, Murtaza I, Wang K, Li PF*. Cardiac hypertrophy is negatively regulated by miR-541. Cell Death & Diseases. 2014 Apr 10;5:e1171. doi: 10.1038/cddis.2014.141. (*Corresponding author)
  49. Wang Y, Wang K, Wang JX, Li PF*. PiRNAs link epigenetic modifications to reprogramming. Histol Histopathol. 2014 Apr 23. [Epub ahead of print] Review. (*Corresponding author)
  50. Wang Y, Wang K, Wang JX, Li PF*. PiRNAs link epigenetic modifications to reprogramming. Histol Histopathol. 2014;29:1489-97. Review. (*Corresponding author)
  51. Li M, Xia P, Du Y, Liu S, Huang G, Chen J, Zhang H, Hou N, Cheng X, Zhou L, Li PF, Yang X, Fan Z. T-cell Immunoglobulin and ITIM Domain (TIGIT) Receptor/Poliovirus Receptor (PVR) Ligand Engagement Suppresses Interferon-γ Production of Natural Killer Cells via β-Arrestin 2-mediated Negative Signaling. J Biol Chem. 2014;289:17647-57.
  52. Wang K, Sun T, Li N, Wang Y, Wang JX, Zhou LY, Long B, Liu CY, Liu F, Li PF*. MDRL lncRNA regulates the processing of miR-484 primary transcript by targeting miR-361. PLoS Genet. 2014 Jul 24;10(7):e1004467. (*Corresponding author)
  53. Wang K, An T, Zhou LY, Liu CY, Zhang XJ, Feng C, Li PF*. E2F1-regulated miR-30b suppresses Cyclophilin D and protects heart from ischemia/reperfusion injury and necrotic cell death. Cell Death and Differentiation.  2015;22:743-54 (*Corresponding author)
  54. Chen J, Hao L, Li C, Ye B, Du Y, Zhang H, Long B, Zhu P, Liu B, Yang L, Li PF, Tian Y, Fan Z. The Endoplasmic Reticulum Adaptor Protein ERAdP Initiates NK Cell Activation via the Ubc13-Mediated NF-κB Pathway. J Immunology. 2015;194:1292-303.
  55. Wang K, Liu CY, Zhang XJ, Feng C, Zhou LY, Zhao Y*, Li PF*. miR-361-regulated prohibitin inhibits mitochondrial fission and apoptosis and protects heart from ischemia injury. Cell Death and Differentiation. 2015;22:1058-68. (*Corresponding author)
  56. Wang JX, Zhang XJ, Feng C, Sun T, Wang K, Wang Y, Li PF*. MicroRNA-532-3p regulates mitochondrial fission through targeting apoptosis repressor with caspase recruitment domain in doxorubicin cardiotoxicity. Cell Death & Disease. 2015, 12;6:e1677. doi: 10.1038/cddis.2015.41. (*Corresponding author)
  57. Wang JX, Gao J, Ding SL, Wang K, Jiao JQ, Wang Y, Sun T, Zhou LY, Long B, Zhang XJ, Li Q, Liu JP, Feng C, Liu J, Gong Y, Zhou Z, Li PF*. Oxidative Modification of miR-184 Enables It to Target Bcl-xL and Bcl-w. Molecular Cell. 2015 May 27. pii: S1097-2765(15)00339-1. doi: 10.1016/j.molcel.2015.05.003. [Epub ahead of print] (*Corresponding author)
  58. Wang K, Liu CY, Zhou LY, Wang JX, Wang M, Zhao B, Zhao WK, Xu SJ, Fan LH, Zhang XJ, Feng C, Wang CQ, Zhao YF, Li PF*. APF lncRNA regulates autophagy and myocardial infarction by targeting miR-188-3p. Nature Communication. 2015 Apr 10;6:6779. doi: 10.1038/ncomms7779. (*Corresponding author)
  59. Wang JX, Zhang X, Li Q, Wang K, Wang Y, Jiao J, Feng C, Teng S, Zhou LY, Gong Y, Zhou Z, Liu J, Wang JL, Li PF* MicroRNA-103/107 Regulate Programmed Necrosis and Myocardial Ischemia/Reperfusion Injury Through Targeting FADD. Circ Res. 2015 Jun 2. pii: CIRCRESAHA.114.305781. [Epub ahead of print] (*Corresponding author)
  60. Wang K, Zhou LY, Wang JX, Wang Y, Sun T, Zhao B, Yang YJ, An T, Long B, Li N, Liu CY, Gong Y, Gao JN, Dong YH, Zhang J, Li PF*. E2F1-dependent miR-421 regulates mitochondrial fragmentation and myocardial infarction by targeting Pink1. Nature Communication. 2015 Jul 17;6:7619. doi: 10.1038/ncomms8619. (*Corresponding author)


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