Education

Biography

Research Interest

Research interests are to develop animal models of atrial and ventricular tachycardia and fibrillation and to determine their mechanisms and control using novel small molecule drugs with specific molecular targets. Our studies rely on mapping cardiac activation patterns and single cardiac cell recordings from preparations scaling from isolated tissue to whole heart level.

Professional Activities:

Publications

1. Hamabe A, Okuyama Y, Miyauchi Y, Zhou S, Pak H-N, Karagueuzian HS, Fishbein MC, Chen P-S: Correlation between anatomy and electrical activation in canine pulmonary veins. Circulation 107:1550-1555, 2003
2. Karagueuzian, HS, Fenoglio JJ, Jr., Weiss MB, Wit AL: Protracted ventricular tachycardia induced by premature stimulation of the canine heart after coronary artery occlusion and reperfusion Circ Res 44: 833-846, 1979.
3. Fenoglio, JJ, Jr., Karagueuzian HS, Friedman PL, Albala A, Wit AL: Time course of infarct growth toward the endocardium after coronary occlusion. Am J Physiol (Heart and Circulation) 236: H370, 1979.
4. Gauduel Y, Karagueuzian HS, Deleiris J: Deleterious effects of endogenous catecholamine on hypoxic myocardial cells following reoxygenation. J Molec Cellular Cardiol 11: 717-731, 1979.
5. Karagueuzian HS, Fenoglio JJ, Jr., Weiss MB, Wit AL: Coronary occlusion and reperfusion: Effects on subendocardial cardiac fibers. Am J Physiol 238: (Heart & Circulatory Physiology) H581-H593, 1980.
6. Karagueuzian HS, Katzung, BG: Relative inotropic and arrhythmogenic effects of five cardiac steroids in ventricular myocardium. Oscillatory after potentials and the role of endogenous catecholamine. J Pharmacol Exp Ther 218: 348-356, 1981.
7. Karagueuzian HS, Pennec JP, Deroubaix E, de Leiris J, Coraboeuf E: Effects of excess free fatty acids on the electrophysiological properties of ventricular specialized conducting tissue. A comparative study between the sheep and the dog. J Cardiovasc Pharmacol 4: 462-468, 1982.
8. Karagueuzian HS, Katzung BG: Voltage-clamp studies of transient inward current and mechanical oscillations induced by ouabain in ferret papillary muscle. J Physiol (London) 327: 255-271, 1982.
9. Karagueuzian HS, Katzung BG: Biphasic effects of acetylstrophanthidin on automaticity in guinea pig ventricular muscle. European J Pharmacol 79:175-183, 1982.
10. Karagueuzian HS, Fujimoto T, Katoh T, Peter T, McCullen A, Mandel WJ: Suppression of ventricular arrhythmias by propafenone, a new antiarrhythmic agent, during acute myocardial infarction in the conscious dog. A comparative study with lidocaine. Circulation 66: 1190-1198, 1982.
11. Katoh T, Karagueuzian HS, Jordan J, Mandel WJ: The cellular electrophysiological mechanism of disopyramide's dual actions on rabbit sinus node function. Circulation 66: 1216-1224, 1982.
12. Karagueuzian HS, Takao K, McCullen A, Mandel WJ, Peter T: Electrophysiologic and hemodynamic effects of propafenone, a new antiarrhythmic agent, on the anesthetized, closed-chest dog: comparative study with lidocaine. Am Heart J 107: 418-424, 1984.
13. Hamer A, Karagueuzian HS, Sugi K, Zaher CA, Mandel WJ, Peter T: Factors related to the induction of ventricular fibrillation in the normal canine heart by programmed electrical stimulation. J Am Coll Cardiol 3: 751-759, 1984.
14. Sugi K, Karagueuzian HS, Fishbein MC, McCullen A, Sato Y, Ganz W, Mandel WJ, Peter T: Spontaneous ventricular tachycardia associated with isolated right ventricular infarction, one day after right coronary artery occlusion in the dog. Studies on the site of origin and mechanism. Am Heart J 109: 232-244, 1985.
15. Karagueuzian HS, Sugi K, Ohta M, Mandel WJ, Peter T:  The efficacy of lidocaine and verapamil alone and in combination on spontaneously occurring automatic ventricular tachycardia in conscious dogs one day after right coronary artery occlusion. Am Heart J 111: 438-446, 1986.
16. Karagueuzian HS, Ohta M, Drury JK, Fishbein MC, Meerbaum S, Corday E, Mandel WJ, Peter T: Coronary venous retroinfusion of procainamide:  A new approach for the management of spontaneous and inducible sustained ventricular tachycardia during myocardial infarction.  J Am Coll Cardiol 7: 551-563, 1986.
17. Karagueuzian HS, Sugi K, Ohta M, Fishbein MC, Mandel WJ, Peter T: Inducible sustained ventricular tachycardia and ventricular fibrillation in conscious dogs with isolated right ventricular infarction. Relation to infarct structure. J Am Coll Cardiol 7: 850-858, 1986.
18. Karagueuzian HS, Sugi K, Ohta M, Meesmann M, Takeshi I, Mandel WJ, Peter T:  The efficacy of cibenzoline and propafenone against inducible sustained and non-sustained ventricular tachycardia in conscious dogs with isolated chronic right ventricular infarction: A comparative study with procainamide. Am Heart J 112: 1173-1183, 1986.
19. Ohta M, Karagueuzian HS, Mandel WJ, Peter T: Chronic acute effects of amiodarone on delayed after depolarization and triggered automaticity in rabbit ventricular myocardium. Am Heart J 113: 289-296, 1987.
20. Katoh T, Karagueuzian HS, Sugi K, Ohta M, Mandel WJ, Peter T: Effects of propafenone on sinus nodal and ventricular automaticity. In vitro in vivo correlation.  Am Heart J 113(4): 941-952, 1987.
21. Siegel RJ, Fealy M, Edwalds G, Karagueuzian HS, Fishbein MC: Immunohistochemical localization of procainamide in normal, ischemic and necrotic canine myocardium during acute experimental myocardial infarction. Am Heart J 113: 1383-1389, 1987.
22. Meesmann M, Karagueuzian HS, Ino T, Fishbein MC, Mandel WJ, Peter T: Selective perfusion of ischemic myocardium during coronary venous retroinjection. A study of the causative role of venoarterial and venoventricular pressure gradients. J Am Coll Cardiol 10:887-897, 1987.
23. Sugi K, Karagueuzian HS, Fishbein MC, Mandel WJ, Peter T: Cellular electrophysiological characteristics of surviving subendocardial fibers in chronically infarcted right ventricular myocardium susceptible to inducible sustained ventricular tachycardia. Am Heart J 114:559-569, 1987.
24. Gang ES, Peter T, Karagueuzian HS, Mandel WJ, Meesmann M: A decline in the ventricular fibrillation threshold following successive premature ventricular extrastimuli:  A possible explanation for the induction of fibrillation during programmed stimulation with multiple extrastimuli. Cardioavsc Res 21:790-795, 1987.
25. Ino T, Karagueuzian HS, Hong K, Meesmann M, Mandel WJ, Peter T: Relation of monophasic action potential recorded with contact electrode to underlying transmembrane action potential properties in isolated cardiac tissue. A systematic microelectrode validation study. Cardiovasc Res 22:255-264, 1988.
26. Gang ES, Peter T, Nalos PC, Meesmann M, Karagueuzian HS, Mandel WJ, Oseran DS, Myers MR: Subthreshold atrial pacing in patients with a left-sided accessory pathway:  an effective new method for terminating reciprocating tachycardia. J Am Coll Cardiol, 11:515-521, 1988.
27. Hong K, Karagueuzian HS, Mandel WJ:  Comparative electrophysiologic, antiarrhythmic and proarrhythmic effects of quinidine and dihydroquinidine. In vivo and in vitro studies. J Electrophysiology, 3:393-405,1989.
28. Karagueuzian HS, Khan SS, Peters W, Mandel WJ, Diamond GA: Nonhomogeneous local atrial activity during acute atrial fibrillation. Dynamic and spectral analysis. PACE, 13:1937-1942, 1990.
29. Karagueuzian HS, Khan SS, Mandel WJ, Hong K, Diamond GA: Nonlinear dynamic analysis of temporally heterogeneous action potential characteristics. PACE, 13:2113-2118, 1990.
30. Denton TA, Diamond GA, Khan SS, Karagueuzian HS: Fascinating rhythms: A primer on chaos theory and its application to cardiology. Am Heart J, 120:1419-1440, 1990. 
31. Meesmann M, Karagueuzian HS, Ino T, McGrath MF, Mandel WJ: The role of enhanced vagal activity on ischemic ventricular tachycardia. Pharmacologic basis of inefficiency. Am Heart J, 121:1703-1713, 1991.
32. Kogan BY, Karplus WJ, Billett BS, Pang AT, Karagueuzian HS, Khan SS: The simplified FitzHugh-Nagumo model with action potential restitution: effects on 2-D wave propagation. PHYSICA-D, 50:327-340, 1991.
33. Khan SS, Denton TA, Karagueuzian HS, Diamond GA: Effect of noise and filtering on phase plane plots and dimension for simple periodic signals. IEEE (Nonlinear Dynamics), 13:2232-2233, 1991.
34. Kogan BY, Karplus WJ, Billett BS, Pang AT, Khan SS , Mandel WJ, Karagueuzian HS: The role of diastolic outward current deactivation kinetics on the induction of spiral waves. PACE, 14:1688-1693, 1991.
35. Peters W, Gang ES, Okazaki H, Solingen S, Karagueuzian HS, Mandel WJ: Acute effects of intravenous propafenone on the internal ventricular defibrillation threshold. Am Heart J, 122:1355-1360, 1992.
36. Karagueuzian HS, Kogan BY, Khan SS, Denton TA, Karplus WJ, Mandel WJ, Diamond GA: Induction of cellular chaos during quinidine toxicity. The predictive power on nonlinear dynamical analysis for drug-induced proarrhythmias. A hypothesis. J Electrocardiology, 24: (Suppl), 91-96, 1992.
37. Denton TA, Diamond GA, Khan SS, Karagueuzian HS: Can the techniques of nonlinear dynamic analysis detect chaos in electrocardiographic signals. J Electrocardiology, 24: (Suppl), 84-90, 1992.
38. Kobayashi Y, Gotoh M, Mandel WJ, Karagueuzian HS: Increased tempo-spatial dispersion of repolarization during double premature stimulation in the intact ventricle. PACE, 15:-II, 2194-2199, 1992
39. Karagueuzian HS, Denton TA, Gotoh M, Khan SS, Diamond GA, Mandel WJ: Phase plane plot of electrograms as a marker of ventricular electrical instability during acute ischemia: initial experimental results and potential clinical applications. PACE, 15-II, 2188-2193, 1992.
40. Kobayashi Y, Peters W, Khan SS, Mandel WJ, Karagueuzian HS: Cellular mechanisms of differential action potential duration in canine ventricular muscle cells during single vs. double premature stimuli. Circulation, 86:955-967, 1992.
41. Karagueuzian HS, Khan SS, Hong K, Kobayashi Y, Dentom TA, Mandel WJ, Diamond GA: Action potential alternans and irregular dynamics during quinidine intoxication in ventricular muscle cells. Implications to proarrhythmias. Circulation, 87:1661-1672 1993.
42. Fan, W., Gotoh, M., McCullen, A., Karagueuzian, H.S., and Chen, P.-S. Reappraisal of effective refractory period testing. Am J Physiol 267:H406-H410, 1994.
43. Bonometti C, Hwang C, Hough D, Lee JJ, Fishbein MC, Karagueuzian HS, Chen P-S: Interaction between strong electrical stimulation and reentrant wavefronts in canine ventricular fibrillation. Circ Res, 77:407-416, 1995.
44. Ino T, Mandel WJ, Karagueuzian HS: Cellular mechanisms of ventricular bipolar electrograms showing double and fractionated potentials. J Am Coll Cardiol, 26:1080-1089, 1995.
45. Cha Y-M, Uchida T, Wolf PL, Peters BB, Fishbein MC, Karagueuzian HS, Chen P-S: Effects of chemical subendocardial ablation on activation rate gradient during ventricular fibrillation. Am J Phyiol: 269 (Heart Circ. Physiol. 38) H1998-H2009, 1995
46. Lee JJ, Kamjoo K, Hough D, Hwang C, Fan W, Fishbein MC, Bonometti C, Ikeda T, Karagueuzian HS, Chen P-S: Reentrant wavefronts in Wigger's stage II ventricular fibrillation. Characteristics, and mechanisms of termination and spontaneous regeneration. Circ Res 78:660-675, 1996.
47. Ikeda T, Uchida T, Mandel WJ, Fishbein MC, Chen P-S, Karagueuzian HS: Mechanism of spontaneous termination of functional reentrant wave fronts in isolated canine right atrium. Evidence for the presence of an excitable gap but nonexcited core. Circulation 94:1962-1973, 1996
48. Gotoh M, Karagueuzian HS, Chen P-S: Anisotropic repolarization in ventricular tissue. Am J Physiol, 272:H107-H1113, 1997
49. Garfinkel A, Walter DO, Chen P-S, Karagueuzian HS, Kogan B, Evans S, Karpoukhin M, Hwang C, Uchida T, Gotoh M, Nwasokwa O, Sager P, Weiss JN: Quasiperiodicity and chaos in cardiac fibrillation. J Clin Invest, 99:305-314, 1997
50. Gotoh M, Uchida T, Mandel WJ, Chen P-S, Karagueuzian HS: Cellular graded responses and ventricular vulnerability to reentry by a critical premature stimulus in isolated canine ventricle. Circulation, 95:2141-2154, 1997
51. Ikeda T, Uchida T, Hough D, Fishbein MC, Mandel WJ, Chen P-S, Karagueuzian HS: Meandering and unstable reentrant wave fronts induced by acetylcholine in isolated canine right atrium: Am J Physiol, 273 (Heart Circ Physiol, 42) :H356-H370, 1997
52. Kamjoo K, Uchida T, Ikeda T, Fishbein MC, Garfinkel A, Weiss JN, Karagueuzian HS, Chen P-S: The importance of location and timing of electrical stimuli in terminating sustained functional reentry in isolated swine ventricular tissues. Evidence in support of small reentrant circuits. Circulation, 96:2048-2060, 1997
53. Ikeda T, Czer L, Trento A, Hwang C, Ong JJC, Hough D, Fishbein MC, Mandel WJ, Karagueuzian HS, Chen P-S: Induction of meandering functional reentrant wave front in isolated human atrial tissues. Circulation, 96:3013-3020, 1997 
54. Ikeda T, Yashima M, Uchida T, Hough D, Fishbein MC, Mandel WJ, Chen P-S, Karagueuzian HS: Attachment of meandering reentrant wave fronts to anatomical obstacles in the atrium. Role of obstacle size. Circulation Research, 81:753-764, 1997
55. Kim YH, Garfinkel A, Ikeda T, Wu T-J, Athill CA, Weiss JN, Karagueuzian HS, Chen P-S: Spatiotemporal Complexity of Ventricular Fibrillation Revealed by Tissue Mass Reduction in Isolated Swine Right Ventricle. Further evidence for the quasiperiodic route to chaos hypothesis. J Clin Invest, Nov 15;100(10):2486-2500, 1997
56. Kim TD, Kwan Y, Lee JJ, Ikeda T, Uchida T, Kamjoo K, Kim Y-H, Ong JJC, Athill CA, Wu T-J, Czer L, Karagueuzian HS, Chen P-S: Patterns of spiral tip motion in cardiac tissues. Chaos, 8:137-148, 1998
57. 56 Kwan YU, Fan W, Hough D, Fishbein FC, Karagueuzian, HS, Chen, P-S, Effects of procainamide on wave front dynamics during ventricular fibrillation in open-chest dogs.  Circulation, 97:1828-1836, 1998
58. Wu TJ, Ong JJC, Hwang C, Lee JJ, Fishbein MC, Czer L, Trento A, Blanche C, Kass RM, Mandel WJ, Karagueuzian HS, Chen P-S: Characteristics of wave fronts during ventricular fibrillation in human hearts with dilated cardiomyopathy: Role of increased fibrosis in the generation of reentry. J Am Coll Cardiol, 32:187-196, 1998
59. Wu T-J, Yashima M, Xie F, Athill CA, Kim Y-H, Fishbein MC, Qu Z, Garfinkel A, Weiss JN, Karagueuzian HS, Chen P-S: Role of pectinate bundles in the generation and maintenance of intraatrial reentry: Potential implications for the mechanism of conversion between atrial fibrillation and atrial flutter.  Circulation Research, 83:448-462, 1998
60. Athill C, Ikeda T, Kim Y-H, Wu T-J, Fishbein MC, Karagueuzian HS, Chen P-S: Transmembrane potential properties at the core of functional reentrant wave fronts in isolated canine right atria.  Circulation, 98:1556-1567, 1998
61. Karagueuzian HS, Athill CA, Yashima M, Ikeda T, Wu T-J, Mandel, WJ, Chen, P-S: Transmembrane potential properties of atrial cells at different sites of a spiral wave reentry. Cellular evidence for an excitable but non-excited core. PACE 21(Part II):2360-2365, 1998
62. Uchida T, Yashima M, Gotoh M, Qu Z, Garkinkel A, Weiss JN, Fishbein MC, Mandel, WJ, Chen, P-S, Karagueuzian HS. Mechanism of acceleration of functional reentry in the ventricle.  Effects of ATP-sensitive potassium channel opener. Circulation, 99:704-12, 1999
63. Ohara T, Yashima M, Hamzei A, Park A, Kim Y-H, Mandel WJ, Chen P-S, Karagueuzian HS: Nicotine increases spatiotemporal complexity of ventricular fibrillation wave fronts on the epicardial border zone of healed canine infarcts. J Cardiovasc Pharmacol and Therapeutics 4:121-127, 1999
64. Cao J-M, Qu Z, Kim Y-H, Wu T-J, Garfinkel A, Weiss JN, Karagueuzian HS, Chen P-S: Spatiotemporal heterogeneity in the induction of ventricular fibrillation induced by rapid pacing. The importance of cardiac restitution. Circulation Research 84:1318-1331, 1999
65. Hwang C, Karagueuzian HS, Chen P-S: Idiopathic paroxysmal atrial fibrillation induced by a focal discharge mechanism in the left superior pulmonary vein. Possible role of the ligament of Marshal. J Cardiovasc Electrophysiol 10:636-648, 1999
66. Kim Y-H, Yashima M, Wu T-J, Chen P-S, Karagueuzian HS: Mechanism of procainamide-induced prevention of spontaneous wave break during ventricular fibrillation. Insight into the fibrillation wave fronts. Circulation, 100:666-674, 1999
67. Doshi R, Kim Y-H, Wu T-J, Karagueuzian HS, Chen P-S: Relation between ligament of Marshal and adrenergic atrial tachyarrhythmia. Circulation 100:876-883, 1999
68. Wu, T-J, Yashima M, Doshi R, Kim Y-H, Athill CA, Ong JJC, Czer L, Trento A, Kass RM, Blanche C, Kass RM, Garfinkel A, Weiss JN, Fishbein MC, Karagueuzian HS, Chen P-S: Relation between the cellular repolarization characteristics and the critical mass for human ventricular fibrillation  J Caridovasc Electrophysiol, 10:1077-86, 1999
69. Kim Y-H, Xie F, Yashima M, Wu T-J, Valderrabáno M, Lee M-H, Ohara T, Voroshilovsky O, Doshi R, Fishbein MC, Qu Z, Garfinkel A, Weiss JN, Karagueuzian HS, Chen P-S: Role of papillary muscle in the generation and maintenance of reentry during ventricular tachycardia and fibrillation in isolated swine right ventricle. Circulation, 100:1450-1459, 1999
70. Cao J-M, Chen LS, Wolf PL, Ohara T, Lee M-H, Kenknight BH, Karagueuzian HS, Fishbein MC, Chen P-S: Nerve sprouting and sudden cardiac death. Circ Res 86: 816-821, 2000
71. Garfinkel A, Karagueuzian HS, Weiss JN, Chen P-S: Preventing ventricular fibrillation by flattening cardiac restitution. Proc Natl Acad Sci USA, 97:6061-6066, 2000. (A figure of this paper made the cover of the Journal)
72. Yashima M, Ohara T, Cao J-M, Kim Y-H, Fishbein MC, Mandel WJ, Chen P-S, Karagueuzian HS: Nicotine increases ventricular vulnerability to fibrillation in hearts with healed myocardial infarction. Am J Physiol (Heart and Circulatory Physiology) 278, H2124-H2133, 2000
73. Voroshilovski O, Lee M-H, Ohara T, Huang HLA, Sweldow CD, Karagueuzian HS, Chen P-S: Mechanisms of ventricular fibrillation induction by 60 HZ alternating current in isolated swine right ventricle: importance of nonuniform recovery of excitability and the cardiac restitution properties. Circulation 102:1569-1574, 2000
74. Kim DT, Lai AC, Hwang C, Fan LT, Karagueuzian HS, Chen P-S, Fishbein MC: The Ligament of Marshall: A structural analysis in human hearts with implications for atrial arrhythmias. J Am Coll Cardiol, 36:1324-1327, 2000.  (A figure of this paper made the cover of the Journal)
75. Athill CA, Wu TJ, Yashima M, Kim Y-H, Weiss JN, Hunag H-L A, Karagueuzian HS, Chen P-S: Influence of wavefront dynamics on transmembrane potential characteristics during atrial fibrillation. J Cardiovasc Electrophysiol, 11:913-921, 2000
76. Omichi C, Lee M-H, Ohara T, Naik AM, Karagueuzian HS, Chen P-S: Cardiac action potential recorded with pure iridium metal microelectrode. A comparative study with glass microelectrode studies. Am J Physiol, 279:H3113-3117, 2000
77. Valderrabáno M, Kim Y-H, Yashima M, Wu T-J, Karagueuzian HS, Chen P-S: Obstacle-induced transition from ventricular fibrillation to ventricular tachycardia in isolated swine right ventricles. J Am Coll Cardiol 36:2000-8, 2000
78. Lai, AC, Wallner K, Cao J-M, Chen L-S, Karagueuzian HS, Fishbein MC, Chen P-S Sharifi BG: Co-localization of tenascin and sympathetic nerves in a canine model of nerve sprouting and sudden cardiac death.  J Cardiovasc Electrophysiol 11: 1345-1351, 2000
79. Chang CM, Wu TJ, Zhou SM, Doshi RN, Lee MH, Ohara T, Fishbein MC, Karagueuzian HS, Chen P-S, Chen L-S: Nerve sprouting and sympathetic hyperinnervation in a canine model of atrial fibrillation produced by prolonged right atrial pacing. Circulation, 103: 22-25, 2001
80. Wu TJ, Ong JJC, Chang C-M, Doshi RN, Yashima M, Huang H-L A, Fishbein MC, Ting C-T, Karagueuzian HS, Chen P-S: Pulmonary veins and ligament of Marshall as sources of rapid activations in a canine model of sustained atrial fibrillation. Circulation 103:1157-1163, 2001
81. Ohara T, Cao J-M, Fishbein MC, Mandel WJ, Chen P-S, Karagueuzian HS: Increased wavebreak during ventricular fibrillation in the epicardial border zone of hearts with healed myocardial infarction. Circulation 103:1465-1472, 2001
82. Lee M-H, Lin S-F, Ohara T, Omichi C, Okuyama Y, Chudin E, Garfinkel A, Weiss JN, Karagueuzian HS, Chen P-S. The effects of diacetyl monoxime and cytochalasin D on action potential duration restitution and the dynamics of ventricular fibrillation in isolated swine right ventricles. Am J Physiol 280: H2689-H2696, 2001
83. Valderrábano M. Lee M-H, Ohara, T, Lai, AC, Fishbein MC, Lin S-F, Karagueuzian HS, Chen P-S: Dynamics of intramural and transmural reentry during ventricular fibrillation in isolated swine ventricles. Circ Res 88: 839-848, 2001
84. Lee M-H, Qu Z, Fishbein GA, Lamp ST, Chang EH, Ohara T, Voroshilovski O, Kil JR, Hamzei A, Wang N, Lin S-F, Weiss JN, Garfinkel A, Karagueuzian HS, Chen P-S: Pattern of wavebreak during ventricular fibrillation in isolated swine right ventricle. Am J Physiol, 281:H253-265, 2001
85. Wang NC, Lee M-H, Ohara T, Voroshilovski, Karagueuzian HS, Chen P-S: Optical mapping of ventricular defibrillation in isolated swine right ventricles: demonstration of a postshock isoelectric window after near-threshold defibrillation shocks. Circulation, 104: 227-233, 2001
86. Zhou S, Cao J-M, Tebb ZD, Ohara T, Huang H-L, Omichi C, Lee M-H, KenKnight BH, Chen L-S, Fishbein MC, Karagueuzian HS, Chen P-S: Modulation of QT interval by cardiac sympathetic nerve sprouting and the mechanisms of ventricular arrhythmia in a canine model of sudden cardiac death. J Cardiovasc Electrophysiol, 12:1068-073, 2001
87. Wu TJ, Kim Y-H, Yashima M, Athill CA, Ting C-T, Karagueuzian HS, Chen P-S: Progressive action potential duration shortening and the conversion from atrial flutter to atrial fibrillation in the isolated canine right atrium. J Am Coll Cardiol, 38:1757-1765, 2002.
88. Valderrábano M. Yang J, Omichi C, Kil J, Lamp ST, Qu Z, Lin F-S, Karagueuzian HS, Garfinkel A, Chen P-S, Weiss JN: Frequency analysis of ventricular fibrillation in ventricles. Circ Res 90: 213-222, 2002
89. Omichi C, Lee M-H, Ohara T, Karagueuzian HS, Chen P-S: Effects of amiodarone on wave front dynamics during ventricular fibrillation in isolated swine right ventricle. Am J Physiol (Heart & and Circulatory Physiology) Am J Physiol 282:H1063-1070, 2002
90. Tsai J, Ca J-M, Zhou S, Swissa M, Cates A, Kenknight BH, Chen LS, Karagueuzian HS, Chen P-S: T wave alternans as a predictor of spontaneous ventricular tachycardia in a canine model of sudden cardiac death. J Cardiovasc Electrophys 13:51-55, 2002
91. Swissa M, Ohara T, Lee M-H, Kaul S, Shah PK, Chen P-S, Karagueuzian HS: Sildenafil-nitric oxide donor combination promotes ventricular tachyarrhythmias in the swine right ventricle. Am J Physiol, Heart & Circulatory Physiology, 282: H1787-1792, 2002
92. Swissa M, Qu Z, Ohara T, Lee M-H, Lin S-F, Garfinkel A, Karagueuzian HS, Weiss JN, Chen P-S: Action potential duration restitution and ventricular fibrillation due to rapid focal excitation. Am J Physiol, Heart & Circulatory Physiology, 282: H1915-1923, 2002
93. Hamzei A, Ohara T, Lee M-H, Lin F-S, Voroshilovski O, Chen P-S, Karagueuzian HS: The role of approximate entropy in predicting ventricular defibrillation threshold. J Cardiovasc Pharmacol Ther 7:45-52, 2002