Associate Professor of Obstetrics and Gynecology
Wayne State University School of Medicine
Detroit, Michigan, USA
Phone: 313-577-8910
E-mail: nnayak@med.wayne.edu
Education
BVSc & AH |
1986 |
Orissa University of Agriculture and Technology, Bhubaneswar, India |
MVSc |
1989 |
Orissa University of Agriculture and Technology, Bhubaneswar, India |
PhD |
1998 |
All India Institute of Medical Sciences, New Delhi, India |
Postdoctoral Fellowship |
1998-2000 |
Oregon National Primate Research Center, Oregon Health Sciences University, Portland, OR, USA. |
Biography
Nihar R. Nayak, DVM, PhD, is an Associate Professor in the Department of Obstetrics and Gynecology at the Wayne State University School of Medicine. Dr. Nayak has extensive research experience in the field of reproductive biology, particularly on endometrial physiology, implantation, placentation, and pathophysiology of pregnancy diseases.His current research is focused on the mechanisms of angiogenesis and vascular remodeling during pregnancy, with emphasis on various vascular complications during pregnancy, including preeclampsia.
Research Interest
- Pregnancy
- Implantation
- Preeclampsia
- Contraception
- Placental function
- Endometrial angiogenesis and bleeding
- Vascular complications during pregnancy
Professional Activities:
1989 |
Veterinary Surgeon (SA), Dept. of Vet. Services, Govt. of Orissa, India |
1989-1998 |
Assistant Professor, Orissa University of Agriculture and Technology, India |
1998-2000 |
Postdoctoral Fellow, Oregon National Primate Research Center, Oregon, USA |
2000-2001 |
Staff Scientist, Oregon National Primate Research Center, Beaverton, OR, USA |
2001-2004 |
Research Associate, Department of Gynecology and Obstetrics, Stanford University |
2004-2005 |
Senior Research Scientist, Department of Gynecology and Obstetrics, Stanford University |
2001-2005 |
Co-director, Reproductive Endocrinology Laboratory, Stanford University |
2002-2005 |
Co-director, The NIH U54 Tissue and DNA Bank at Stanford University |
2005-2012 |
Assistant Professor and Director of Translational Research, Division of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology, Stanford University. |
2012-2014 |
Associate Professor of Obstetrics and Gynecology, Research Director of Translational Research, Division of Maternal and Fetal Medicine, Stanford University. |
2014 |
present Associate Professor, Department of Obstetrics and Gynecology, Wayne State University |
Honors And Awards
1982-1986 |
University Merit Scholarship, Orissa University of Agriculture and Technology, India |
1987-1989 |
Junior Fellowship, Indian Council of Agricultural Research |
1989 |
University Gold Medal for First Class First in M.V.Sc. |
1995-1997 |
Research Associate Fellowship, Indian Council of Medical Research |
1996 |
A.V. Tilak-Parvathi Devi Award, the Association of Physiologists and Pharmacologists of India |
1998-2000 |
Postdoctoral Fellowship, the Lalor Foundation, USA |
1999 |
Travel Grant Award, the Endocrine Society, USA. |
1999 |
Burroughs Wellcome Fund Travel Fellow, the Society for the Study of Reproduction, USA. |
2000-2004 |
Junior Investigator Award, the Andrew W. Mellon Foundation, USA |
2004-2009 |
Building Interdisciplinary Research Careers in Women's Health (BIRCWH) Award, the NIH institutional career development award. |
2010 |
Lalor Foundation Merit Award, the Society for the Study of Reproduction (Mentor –Xiujun Fan). |
2010 |
Larry Ewing Memorial Travel Award, the Society for the Study of Reprod. (Mentor - Xiujun Fan). |
2011 |
Preeclampsia Foundation 2011 Vision Grant Award – presented at the Foundation’s annual gala, Saving Grace – A Night of Hope and Gratitude, at New York. |
Publications
- Fan X, Rai A, Kambham N, Sung J, Singh N, Petitt M, Dhal S, Sutton RE, Druzin ML, Gambhir SS, Ambati BK, Cross JC and Nayak NR (2014) Endometrial VEGF induces placental sFlt1 and leads to pregnancy complications. J of Clin Investigation, 124(11):4941-52.
- Fan, X., Petitt, M., Gamboa, M., Huang, M., Dhal, S., Druzin, M.L., Wu, J.C., Chen-Tsai, Y., Nayak, N.R. (2012) Transient, inducible, placenta-specific gene expression in mice. Endocrinology, 153(11):5637-44.
- Fan, X., Kreig, S., Hwang, J.Y., Dhal, S., Kuo, C.J., Lasley, B.L., Brenner, R.M., and Nayak, N.R. (2012) Dynamic regulation of Wnt7a expression in the primate endometrium: implications for postmenstrual regeneration and secretory transformation. Endocrinology, 153(3):1063-9.
- Krieg, S.A., Fan, X., Krieg, A.J., Giaccia, A., Westphal, L.M., Lathi, R.B. and Nayak, N.R. (2012) Differential Gene Regulation in the Decidua of Women with Idiopathic Recurrent Pregnancy Loss. Mol Hum Reprod, 18(9):442-50.
- Sung, J.F., Fan, X., Dhal, S., Dwyer, B., Jafari, A., El-Sayed, Y.Y., Druzin, M.L. and Nayak, N.R. (2011) Decreased Circulating Soluble Tie2 Levels in Preeclampsia May Result from Inhibition of Vascular Endothelial Growth Factor (VEGF) Signaling. J Clin Endocrinol Metab, 96 (7):E1148-52.
- Fan, X., Ren, P., Dhal, S., Bejerano, G., Goodman, S.B., Druzin, M.L., Gambhir, S.S. and Nayak, N.R. (2011) Noninvasive Monitoring of Placenta-Specific Transgene Expression by Bioluminescence Imaging. PLoS ONE, 6(1):e16348.
- Dwyer, B., Kreig, S., Balise, R., Chueh, J., Nayak, N.R., and Druzin, M (2009) Variable expression of soluble fms-like tyrosine kinase 1 in patients at high risk for preeclampsia. The Journal of Maternal-Fetal & Neonatal Medicine, 23:705-11.
- Fan, X., Kreig, S., Kuo, C.J., Wiegand, S.J., Rabinovitch M., Druzin, M., Brenner, R.M., Giudice, L.C., and Nayak, N.R. (2008) VEGF blockade inhibits angiogenesis and postmenstrual reepithelization of endometrium. FASEB J, 22(10):3571-80.
- Kuhnert F, Tam BY, Sennino B, Gray JT, Yuan J, Jocson A, Nayak NR, Mulligan RC, McDonald DM, Kuo CJ (2008) Soluble receptor-mediated selective inhibition of VEGFR and PDGFR{beta} signaling during physiologic and tumor angiogenesis. Proc Natl Acad Sci U S A, 105(29):10185-90.
- Tam BY, Wei K, Rudge JS, Hoffman J, Holash J, Park SK, Yuan J, Hefner C, Chartier C, Lee JS, Jiang S, Nayak NR, Kuypers FA, Ma L, Sundram U, Wu G, Garcia JA, Schrier SL, Maher JJ, Johnson RS, Yancopoulos GD, Mulligan RC, Kuo CJ. (2006) VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis. Nature Medicine, 12:793-800.
- Germeyer, A., Hamilton, A.E., Laughlin, L.S., Lasley, B.L., Brenner, R.M., Giudice, L.C. and Nayak, N.R. (2005) Cellular expression and hormonal regulation of neuropilin-1 and -2 mRNA in the human and rhesus macaque endometrium. J Clin Endocrinol Metab, 90:1783-1790.
- Nayak, N.R., Kuo, C.J., Desai, T.A., Wiegand, S.J., and Giudice, L.C. and Brenner, R.M. (2005) Angiopoietin-1 expression in the primate endometrium: potential role in spiral artery growth. Molecular Human Reproduction, 11:791-799.
- Nayak, N.R. and Brenner, R.M. (2002) Vascular proliferation and vascular endothelial growth factor expression in the rhesus macaque endometrium. J Clin Endocrinol Metab, 87, 1845-1855.
- Nayak, N.R., Critchley, H.O.D., Slayden, O.D., Menrad, A., Chwalisz, K., Baird, D.T., Brenner, R.M. (2000) Progesterone withdrawal up-regulates vascular endothelial growth factor receptor type 2 in the superficial zone stroma of the human and macaque endometrium: Potential relevance to menstruation. J Clin Endocrinol Metab, 85, 3442-3452.
- Zhao, H., Wong, R.J., Kalish, F., Nayak, N.R. and Stevenson, D.K. (2009) Effect of heme oxygenase-1 deficiency on placental development. Placenta 30(10):861-8.
