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Anesthetic Approach in Placental Invasion Anomalies

  Aslan Bilge1*      Aydın Feray2      Gedikli Ahmet1      Uygur Dilek3   

1Anesthesia Clinic Department, Zekai Tahir Burak Training and Research Hospital, University of Health Sciences, Ankara, Turkey
2General Surgery, Clinic of Zekai Tahir Burak Training and Research Hospital, Turkey
3Perinatologist, Close Care Risky Pregnancy Department, Tahir Burak Training and Research Hospital, University of Health Sciences, Ankara, Turkey

*Corresponding author: Bilge Aslan, Anesthesia Clinic Department, Zekai Tahir Burak Training and Research Hospital, University of Health Sciences, Ankara, Turkey, Tel: +90 312 3065184; E-mail:


Placental invasions; Anesthesia management

Introduction and Purpose

Peripartum hemorrhage takes place within the significant reasons for maternal morbidity and mortality. Abnormal placentation is one of the significant reasons for peripartum hemorrhage. The basic forms of abnormal placentation are placenta previa and abnormal invasive placenta [1]. The optimum time for planned delivery for a patient with placenta accreta is around 34-35 weeks following corticosteroid injection. The successful management of placenta accreta includes a multidisciplinary care team approach relying heavily on the prenatal diagnosis of this entity and preparing for surgical management. The aim of this study was to investigate of the cases Caesarean Section (C/S) with the diagnosis of placenta previa and abnormal invasive placenta in terms of anesthesia management, transfusion requirement and problems predicted. The anesthesiologist should act according to the condition of the pregnant and plan the case by communicating with other departments. In such cases, regional anesthesia is sufficient in terms of quality and duration of analgesia and is preferred in our clinic.

Materials and Methods

After the approval of the ethics committee, the records of the patients who underwent cesarean section with the diagnosis of placenta previa/accreta in our hospital between 2008-2018 were reviewed. Demographic data and pregnancy characteristics of the patients (Table 1), type of operation, duration of operation, surgical intervention in cesarean section, perioperative haemodynamic data, ephedrine, vasopressor, crystalloid or colloid consumption. Also, perioperative Erythrocyte Suspension (ES), Fresh Frozen Plasma (FFP), Thrombocyte Suspension (TS) consumption, Preoperative and Postoperative Hemoglobin (Hb), Thrombocyte, Partial Thromboplastin Time (PT), Activated Partial Thromboplastin Time (aPTT), International Normalized Ratio (INR), Alanine Transaminase (ALT) and Aspartate Aminotransferase (AST), Creatine (Cr) values, and the lowest measured hemoglobin value were recorded. Different treatment modalities are applied for peripartum hemorrahage in abnormal placental invasion. Uterine curretage, tamponade devices, peripartum hysterectomies, uterine artery ligation, hypogastric artery ligation, and hypogastric artery ballooning are the examples for the treatment. In our study, we have percentages of treatment methods and percentages of reoperation.

Age (years) 30 ± 12 (18-42)
Height (cm) 160 ± 8 (150-174)
Weight (kg) 80 ± 14 (43-134)
Pregnancy week (wk) 36 ± 4 (24-40)
Number of pregnancy (n) 3 ± 2 (0-5)
Number of births (n) 0.8 ± 1.2 (0-10)
Number of previous cesarean (n) 2 ± 1 (0-3)
Number of patients underwent uterine surgery (n,%) 120 (%10)

Table 1: Demographic data and pregnancy characteristics of patients. Data mean given as ± standard deviation given (minimum-maximum), n (%).


A total of 1200 cases were found 2.5% (n=30) of the cases were placenta accreta, 3.5% (n=42) were placenta percreata; 64% (n=768) were placenta previa totalis and 30% (n=360) were placenta previa marginalist. 48% (n=576) of the cases were regional, 50% (n=600) were general, 2% (n=24) were applied regional and general together. The mean operation time was 60 ± 24 minutes (Table 2). Caesarean was applied to only 80% (n=960) of the cases, additionally to caesarean intrauterine balloon application for 15% (n=180) of cases, hysterectomy for 5% (n=60). Repeat operation was needed for 5% (n=60) of the patients. Preoperative mean Hb value was 12.00 (± 0.8) g.dl-1, platelet value was 210000 (± 8020) µl-1, INR value was 1.4 (± 0.2); postoperative mean Hb value was 10.8 (± 0.5) g.dl-1, thrombocyte value was 150560 (± 4250) µl-1, INR value was 1.2 (± 0.1). Erythrocyte suspension for 40 % (n=480) of patients, TDP for 30% (n=360), thrombocyte suspension for 1% (n=12) and fibrinogen was used for 6% (n=72). In this study, Student-t test was used in statistical evaluation, where numerical variables were not equally distributed between groups; Mann-Whitney U test was used in different distributions. There were significant changes in Hb, platelet and aPTT values (p<0.05). There were significant decreases in these three values (Hb, platelet, aPTT) postoperatively. The intraoperative blood loss and transfusion requirements of patients’ placenta accreta and its variants undergoing cesarean delivery (Tables 3-5).

Placenta accreta (n,%) 30 (2.5%)
Placenta percreata (n,%) 42 (3.5%)
Placenta previa totalis (n,%) 768 (64%)
Placenta previa marginalis (n,%) 360 (30%)
Type  of  anesthesia  (n,%)  Regional,  Time  of discharge   576 (48%), 6 (± 2) day
Type  of  anesthesia  (n,%)  General,  Time  of discharge 600 (50%), 10 (± 3)
Type  of  anesthesia  (n,%)  Regional+General, Time of discharge 24 (2%), 9 (± 3) day
Duration of operation (min) 60 ± 24 (30-230)
Surgical period (min) 56 ± 24 (22-245)
Induction-delivery time (min) 4 ± 2.1 (2-12)

Table 2: Diagnosis and operation time of patients. Data mean given as ± standard deviation given (minimum-maximum), n (%).

Only cesarean (n,%) 960 (80%)
Intrauterine balloon application (n,%) 180 (15%)
Hysterectomy (n,%) 60 (5%)
Bladder repair (n,%) 1 (0.4%)
Patients applied second operation (n,%) 60 (5%)

Table 3: Type of surgery applied to patients. Data were given as n (%).

Pressure systolic (mmHg) 125 (± 12) (60-120)
Pressure diastolic (mmHg) 60 (± 15) (40-80)
Heart (beats/min) 110 (± 12) (70-160)
Heart (beats/min) 80 (± 16) (45-125)
Patients developing hypotension (n,%) 720 (60%)
Patients used ephedrine (n,%) 360 (30%)
Ephedrine (mg) 20 (± 10) (0-40)
Patients used fibrinogen (n,%) 12 (4.6%)
Fibrinogen (g) 0.06 (± 0.04)
Patients used erythrocyte suspension (n,%) 480 (40%)
Erythrocyte suspension (U) 4 (± 2)
Patients used fresh frozen plasma (n,%) 360 (30%)
Fresh frozen plasma (U) 4 (± 1)
Patients used thrombocyte (n,%) 12 (1%)
Thrombocyte (U) 2 (± 0.5)
Crystalloid (ml) 2000 (± 112)
Colloid (ml) 800 (± 150)
Lowest hermoglobin (g.dl-1) 9(± 3.5) (6-12.5)

Table 4: Perioperative hemodynamics, ephedrine usage, liquid, blood, blood product consumptions and the lowest measured hemoglobin values. Data mean given as ± standard deviation given (minimummaximum), n (%).

  Before the operation After the operation
Hemoglobin (g.dl-1)* 12.00 (± 0.8) (7-13.5) 10.8 (± 0.5) (7-13.5)
Platelet (µ.l-1)** 210000 (± 8020)
150560 (± 4250)
PT (second) 12.5 (± 0.5) (10-24) 12.9(± 0.1) (10-19.7)
aPTT (second)*** 26.1 (± 0.1) (16-45) 31.6 (± 0.6) (21-99)
INR (U) 1.4 (± 0.2) (0.9-1.27) 1.2 (± 0.1) (0.8-1.9)
AST 17 (± 1.1) (10-250) 20 (± 2) (10-388)
ALT 18 (± 0.7) (10-180) 25 (± 5) (10-212)
Cr (mg.dl-1) 0.8 (± 0.4) 1.2 (± 0.2)

Table 5: Laboratory results before and after surgery. Data mean given as ± standard deviation given (minimum-maximum).
*, **, ***=Hb, Platelet and a PTT preoperative and postoperative values p<0.05

Discussion and Conclusion

Placenta previa is an obstetric complication that placenta covers the internal cervical OS or placed near the OS, which has an incidence of 0.3-0.6%, is also a risk factor for abnormal invasive placentation [2]. Placenta accreta is one of the important reasons for abnormal invasive placentation postpartum hemorrhage that covers the increta and percreta and it is related to prominent maternal mortality. Surgical morbidity can depend on the degree of the placental invasion. The incidence of the abnormal invasive placentation has been increased from 0.08% to 0.3% in last 10 years depending on the caesarean ratio increase [3].

The risk of abnormal invasive placentation is higher when the caesarean with placenta previa is occurred. Regional anesthesia for cesarean delivery in women with placenta previa is safe [4]. Delivery should take place at an institution with adequate blood banking facilities. The incidence of placenta accreta is rising, primarily because of the rise in cesarean delivery rates. This condition can be associated with massive blood loss at delivery. Prenatal diagnosis by imaging, followed by planning of peripartum management by a multidisciplinary team, may help reduce morbidity and mortality. Women known to have placenta accreta should be delivered by cesarean, and no attempt should be made to separate the placenta at the time of delivery. The majority of women with significant degrees of placenta accreta will require a hysterectomy [5].

Complete placenta previa is associated with an increased risk of hemorrhage compared with incomplete placenta previa. Therefore the distinction between classifications should be factored into anesthetic management protocols [6].

The choice of anesthetic technique in patients with abnormal placentation is controversial. Even in patients who are taken to cesarean with the indication of placenta previa, general anesthesia is more common due to the possibility of bleeding, but there are publications showing that regional anesthesia is safe in these patients. Bleeding amount of the abnormal invasive placentation cases is changing between the median values of 2000-6000 ml which are quite high numbers.

In our study, there was no awakening in patients receiving regional anesthesia. The duration of stay in the ICU of the pregnant women was shorter. Therefore, regional anesthesia decreases mortality. It shortens the time of discharge of pregnant women.

Regardless of the anesthetic technique used, it is recommended for abnormal placentation diagnosed patients that are going to be taken to caesarean, to be performed at least two large vascular access, arterial cannulation should be performed and central venous cannulation should be considered if necessary. Two to five units of erythrocyte suspension must be available. It should be kept in mind that vasoactive drugs such as phenylephrine, ephedrine, and dopamine may be needed [7]. It should be kept in mind that major obstetric hemorrhages may be encountered in cases with abnormal placentation and the necessity of dynamic anesthesia management. Regional anesthesia for cesarean delivery in women with placenta previa is safe. The risk of abnormal invasive placentation is higher when the caesarean with placenta previa is occurred. This condition can be associated with massive blood loss at delivery. If the operation is prolonged or a complication develops, we have the option of limiting regional anesthesia and passing to general anesthesia. In such cases, regional anesthesia is sufficient and preferred for the quality and duration of analgesia. If the pre-operative preparation is complete for the abnormal invasive placentation, the anesthesiologist can reduce mortality and morbidity.


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Article Information


Citation: Bilge A, Feray A, Ahmet G, Dilek U (2019) Anesthetic Approach in Placental Invasion Anomalies. Gynecol Women’s Health Res 1(1):

Copyright: © 2019 Bilge A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Publication history: 

  • Received date: 17 Jan, 2019

  • Accepted date: 03 May, 2019

  • Published date: 09 May, 2019