Zhang, Fan
Daniel Lee Kaplan, PhD
Associate Professor of Biomedical Sciences
  • Florida State University College of Medicine
    Florida, Tallahassee, USA
    Phone: 850-645-0237; Fax: 850-645-5781
    E-mail: daniel.kaplan@med.fsu.edu

Education

  • Ph.D. Yale University, New Haven, Connecticut September 1994 to August 2000
Teaching

It is my teaching philosophy to create an engaged, active learning experience for all students. It is my highest priority to ensure that every student in the class is fully engaged in the course material, and I am fully committed to helping each student learn. I teach postdoctoral fellows, graduate students, medical students, undergraduate students, and high school students and their teachers in my laboratory and in the classroom. I am the course director for Medical Microbiology and Infectious Disease at the Florida State University College of Medicine. The principle goal of this course is to develop outstanding physicians who will diagnose, prevent, and treat infectious disease. We also educate students in the principles of bacteriology, virology, fungal disease, and parasitology, and we prepare students for the Microbiology section of Step 1 of the National Board Exams. My large-group sessions consist of an interactive format that engages the students in case-study analysis. I also developed small-group exercises that are strictly devoted to case study. Upon receiving history and physical exam information, the students work with each other and with their faculty mentors to decide upon a differential diagnosis with relevant lab tests. The students then receive the results of the lab tests, and decide upon a final treatment option. The large- and small-group sessions have been a tremendous success, as measured by the medical students and participating faculty. In addition, I am participating faculty for Pathology 202 and Chromatin Structure, Epigenetics, and Human Health. The Chromatin class is for graduate students, and I teach them to analyze the latest research articles related to chromatin and DNA transactions. I also teach the students to analyze and interpret the primary research, and design their own experiments.

Biography

Daniel Kaplan joined the Florida State University College of Medicine in 2012 as an Associate Professor of Biomedical Sciences. Prior to joining FSU, Dr. Kaplan was an Assistant Professor at Vanderbilt University, where he led a team that published primary research articles that investigated how DNA replication is initiated. As a post-doctoral fellow, Daniel Kaplan worked with National Academy of Science member Mike O’Donnell at Rockefeller University and published manuscripts on the function and mechanism of replication fork helicases. Two of these manuscripts (Mol Cell 2002 and Mol Cell 2004) have been cited by the Faculty of 1000 website. In graduate school, Daniel Kaplan worked with Nobel Laureate Thomas Steitz at Yale University to determine how the bacterial replication fork helicase, DnaB, modulates DNA structure. Dr. Kaplan attended Yale Medical School and received training in cancer research before entering graduate school.

 

Research Interes

  • DNA Replication and Genome Maintenance

 

Professional Activities:

Honors/Awards
  • Awarded tenure at the Florida State University College of Medicine (August 2015).
  • Invited to write a review for a special molecular motors issue of Frontiers in Biosciences, in the Encyclopedia of Bioscience (2012 publication).
  • Invited to submit an article to the journal Methods (2010 publication).
  • Invited to submit an article to the journal Methods in Molecular Biology (2010 publication).
  • Awarded the Scaringe Prize (2004 Gordon Research Conference: “Nucleic Acids”, Newport, Rhode Island, June 2004).
  • Leon and Toby Cooperman Fellow of the Damon Runyon Cancer Research Foundation (2001 to 2004).
  • Distinguished Doctoral Thesis (Awarded by Yale University Degree Committee, December 2000).
  • Howard Hughes Medical Institute Predoctoral Fellow (1995 to 2000).
  • Honor Student at an International Achievement Summit (hosted by the American Academy of Achievement, London, England, October 2000).
  • Nominated for Harold M. Weintraub Graduate Student Award (2000).
  • Poster Presentation Award (Yale University Graduate Student Research Symposium, February 1999).
  • Teaching Prize (Yale University Department of Molecular Biophysics and Biochemistry, June 1998).
  • Grade of Honors in 8 out of 9 Courses (Yale University Graduate School, 1994-1995, other grade is high pass).
  • NIH Cancer Research Fellow (Yale University School of Medicine, 1990-1991).
  • Student Editor of Yale Journal of Biology and Medicine (1989-1991).
  • Graduates with honors from University of Virginia. Phi Beta Kappa
  • Intermediate Honors (awarded to second year students with high academic achievement).
  • Echols Scholar (awarded to incoming students of exceptional promise).
Memberships
  • American Society for Biochemistry and Molecular Biology.
  • American Association for the Advancement of Science.
Patented Inventions
  • Kaplan D, Bruck I (2015) Screening assay for DDK modulators. Serial number: 62/199,984, FSU. US.
Contracts and Grants Funded
  1. Kaplan D (Sep 2015–Aug 2018). Assembly and Activation of the Eukaryotic Replication Fork Helicase. Funded by NIH. (1 R15 GM113167-01A1). Total award $384,781.
  2. Kaplan DL (May 2014–Aug 2014). Supplement to National Science Foundation Grant for Research Opportunity for Undergraduates. Funded by National Science Foundation. Total award $5,500.
  3. Kaplan DL (May 2013–Aug 2013). Supplement to National Science Foundation Grant for Research Opportunity for Undergraduates. Funded by National Science Foundation. Total award $5,500.
  4. Kaplan D, & Kaplan D (Sep 2012–Jul 2015). Roles of Sld2 and Sld3 in the Initiation of DNA Replication. Funded by National Science Foundation. (1265431). Total award $655,000.
    This grant was initially awarded to Vanderbilt University in 2011 (1121534), and the grant transferred to Florida State University in the fall of 2012 (1265431).
  5. Kaplan DL (Aug 2011–Aug 2012). Roles of Sld2 and Sld3 in the Initiation of DNA Replication. Funded by National Science Foundation. (1121534). Total award $190,000.
    This grant was initially awarded to Vanderbilt University in 2011 (1121534), and the grant transferred to Florida State University in the fall of 2012 (1265431).
  6. Kaplan DL (May 2009–Apr 2011). Role of S. cerevisiae Dpb11 in the Initiation of DNA Replication. Funded by Vanderbilt University Discovery Grant. Total award $50,000.
  7. Kaplan DL (Jul 2008–Jun 2012). Kinase Regulation of the Replication Fork Helicase. Funded by American Cancer Society. (RSG-08-124-01-CCG). Total award $714,000.
  8. Kaplan DL (May 2006–Apr 2008). Mechanistic studies of the eukaryotic replication fork helicase. Funded by Vanderbilt University Discovery Grant. Total award $50,000.
  9. Kaplan DL (Sep 2005–Aug 2006). Kinase regulation of the replication fork helicase. Funded by Vanderbilt Ingram Cancer Center Pilot Grant. Total award $35,000.
FSU University Service
  • Grant Reviewer, Council for Research Creativity, Committee on Faculty Research Support (2014–present).
  • Co-founder, Florida State University Nucleic Acids Research Group (2013–present).
  • Member, Budding Yeast Joint Group Lab Meeting (2012–present).
    This meeting is a biweekly meeting with other scientists at FSU that study budding yeast.
  • Member, Fulbright Faculty Committee (2014–2015).
FSU College Service
  • Faculty Advisor, Medical Student Research Interest Group (2016–present).
  • Member, Cancer Research Group (2015–present).
  • Voting member, Faculty Council Executive Committee (2014–present).
  • Faculty Advisor for Medical Students, College of Medicine (2014–present).
  • Member, 1st and 2nd year Course Director Committee for College of Medicine (2012–present).
  • Chair, Faculty Council Executive Committee (2015–2016).
  • Voting Representative, College of Medicine Admissions Committee (2014–2015).
  • Vice-Chair, Faculty Council Executive Committee (2014–2015).
  • I was elected to the Faculty Council Executive Committee on June 30, 2014, and was elected as vice-chair in October, 2014.
FSU Department Service
  • Member, Equipment Committee (2014–present).
  • Member, Cell Cycle Journal Club (2012–present).
  • Reviewer and Participant, Grant Review Workshop (2012–present).

 

Publications

Invited Journal Articles
  1. Kaplan, D. L., & Bruck, I. (2010). Methods to study how replication fork helicases unwind DNA. Methods Mol Biol, 587, 127-35.
    This manuscript was refereed (peer reviewed).
  2. Kaplan, D. L., & Bruck, I. (2010). Methods to study kinase regulation of the replication fork helicase. Methods, 51, 358-62.
  3. Kaplan, D. L. (2006). Replication Termination: Mechanism of Polar Arrest Revealed. Curr Biol, 16, R684-686.
Refereed Journal Articles
  1. Perez-Arnaiz, P., & Kaplan, D. (in press). An Mcm10 mutant defective in ssDNA binding shows defects in DNA replication initiation. J Mol Biol.
  2. Bruck, I., Perez-Arnaiz, P., Colbert, M., & Kaplan, D. (2016). Insights into the Initiation of Eukaryotic DNA Replication. Nucleus, 6, 449-54. Retrieved from http://www.tandfonline.com/doi/full/10.1080/19491034.2015.1115938 doi:10.1080/19491034.2015.1115938
  3. Perez-Arnaiz, P., Bruck, I., & Kaplan, D. (2016). Mcm10 coordinates the timely assembly and activation of the replication fork helicase. Nucleic Acids Res, 44, 315-29. Retrieved from http://nar.oxfordjournals.org/content/44/1/315.long doi:10.1093/nar/gkv1260
  4. Bruck, I., & Kaplan, D. (2015). Conserved mechanism for coordinating replication fork helicase assembly with phosphorylation of the helicase. Proc Natl Acad Sci U S A, 112, 11223-8. Retrieved from http://www.pnas.org/content/112/36/11223.long doi:10.1073/pnas.1509608112
  5. Bruck, I., & Kaplan, D. (2015). The Dbf4-Cdc7 kinase promotes Mcm2-7 ring opening to allow for single-stranded DNA extrusion and helicase assembly. Journal of Biological Chemistry, 290, 1210-21. Retrieved from http://www.jbc.org/content/290/2/1210.longdoi:10.1074/jbc.M114.608232
  6. Bruck, I., & Kaplan, D. (2015). The replication initiation protein Sld3/Treslin orchestrates the assembly of the replication fork helicase during S phase. The Journal of Biological Chemistry, 290, 27414-24. Retrieved from http://www.jbc.org/content/290/45/27414.long doi:10.1074/jbc.M115.688424
  7. Dhingra, N., Bruck, I., Smith, S., Ning, B., & Kaplan, D. (2015). Dpb11 helps control assembly of the Cdc45-Mcm2-7-GINS replication fork helicase. Journal of Biological Chemistry, 290, 7586-601. Retrieved from http://www.jbc.org/content/290/12/7586.long doi:10.1074/jbc.M115.640383.
  8. Bharti, S., Sommers, J., Zhou, J., Kaplan, D., Spelbrink, J., Mergny, J., & Brosh, R. (2014). DNA Sequences Proximal to Human Mitochondrial DNA Deletion Breakpoints Prevalent in Human Disease Form G-Quadruplexes, a Class of DNA Structures Inefficiently Unwound by the Mitochondrial Replicative Twinkle Helicase. Journal of
  9. Biological Chemistry, Sept. 5, 2014, 09/05/2014. Retrieved from http://www.jbc.org/content/early/2014/09/05/jbc.M114.567073.full.pdf+html doi:10.1074/jbc.M114.567073
  10. Bruck, I., & Kaplan, D. L. (2014). The Replication Initiation Protein Sld2 Regulates Helicase Assembly. Journal of Biological Chemistry, 289, 1948-59. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/24307213 doi:10.1074/jbc.M113.532085
  11. Khan, I., Suhasini, A., Banerjee, T., Sommers, J., Kaplan, D., Kuper, J., Kisker, C., & Brosh, R., Jr. (2014). Impact of Age-Associated Cyclopurine Lesions on DNA Repair Helicases. PLoS One, 9, e113293. Retrieved from http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0113293doi:10.1371/journal.pone.0113293
  12. Bruck, I., & Kaplan, D. L. (2013). Cdc45-ssDNA interaction is important for stalling the helicase during replication stress. Journal of Biological Chemistry, 288, 7550-63. doi:10.1074/jbc.M112.440941
  13. Kaplan, D. L., Saleh, O. A., & Ribeck, N. (2013). Single-molecule and bulk approaches to the DnaB replication fork helicase. Front. Biosci, 18, 224-40. doi:PMID: 23276919
  14. Suhasini, A., Sommers, J., Yu, S., Wu, Y., Xu, T., Kelman, Z., Kaplan, D. L., & Brosh, R. (2012). DNA Repair and Replication Fork Helicases are Differentially Affected by an Alkyl Phosphotriester Lesion. J. Biol. Chem, 287, 19188-98.
  15.  Bruck, I., Kanter, D., & Kaplan, D. L. (2011). Enabling Association of the GINS Protein Tetramer with the Mini Chromosome Maintenance (Mcm)2-7 Protein Complex by Phosphorylated Sld2 Protein and Single-stranded Origin DNA. J. Biol. Chem, 286, 36414-26.
  16.  Bruck, I., & Kaplan, D. L. (2011). GINS and Sld3 compete with one another for Mcm2-7 and Cdc45 binding. J. Biol. Chem, 286, 14157-67.
  17.  Bruck, I., & Kaplan, D. L. (2011). Origin Single-stranded DNA Releases Sld3 Protein from the Mcm2-7 Complex, Allowing the GINS Tetramer to Bind the Mcm2-7 Complex. J. Biol. Chem, 286, 18602-13.
  18.  Kanter, D., & Kaplan, D. L. (2011). Sld2 binds to origin ssDNA and stimulates DNA annealing. Nucleic Acids Res, 39, 2580-2592.
  19.  Ribeck, N., Kaplan, D. L., Bruck, I., & Saleh, O. (2010). DnaB helicase activity is modulated by DNA geometry and force. Biophys J, 99, 2170-9.
  20.  Wickersham, C., Cash, K., Pfeil, S., Bruck, I., Kaplan, D. L., Plaxco, K., & Lipman, E. (2010). Tracking a molecular motor with a nanoscale optical encoder. Nano Lett, 10, 1022-1027.
  21.  Bruck, I., & Kaplan, D. L. (2009). Dbf4-Cdc7 phosphorylation of Mcm2 is required for cell growth. J. Biol. Chem, 284, 28823-31.
  22.  Kaplan, D. L., & Bastia, D. (2009). Mechanisms of polar arrest of a replication fork. Mol. Microbiol, 72, 27-285.
  23.  Kanter, D., Bruck, I., & Kaplan, D. L. (2008). Mcm subunits can assemble into two different active unwinding complexes. J. Biol. Chem, 283, 31172-1182.
  24.  Kaplan, D. L., & O'Donnell, M. (2006). RuvA Is a Sliding Collar that Protects Holliday Junctions from Unwinding while Promoting Branch Migration. J. Mol. Biol, 355, 473-490.
  25.  Kaplan, D. L., & O'Donnell, M. (2004). Twin DNA Pumps of a Hexameric Helicase Provide Power to Simultaneously Melt Two Duplexes. Mol. Cell, 15, 453-465.
  26.  Kaplan, D. L., Davey, M., & O'Donnell, M. (2003). Mcm4,6,7 Uses 'Pump in Ring' Mechanism to Unwind DNA by Steric Exclusion and Actively Translocate Along a Duplex. J. Biol. Chem, 278, 49171-49182.
  27.  Kaplan, D. L., & O'Donnell, M. (2003). "Rho Factor: Transcription Termination in Four Steps". Curr. Biol, 13, r714-r716.
  28.  Kaplan, D. L., & O'Donnell, M. (2002). DnaB Drives DNA Branch Migration and Dislodges Proteins While Encircling Two DNA Strands. Mol. Cell, 10, 647-657.
  29.  Kaplan, D. L. (2000). The 3'-tail of a Forked-Duplex Sterically Determines Whether One or Two DNA Strands Pass Through the Central Channel of a Replication Fork Helicase. J. Mol. Biol, 301, 285-299.
  30.  Kaplan, D. L., & Steitz, T. (1999). DnaB from Thermus aquaticus Unwinds Forked Duplex DNA with an Asymmetric Tail Length Dependence. J. Biol. Chem, 274, 6889-6897.
  31.  Kaplan, D. L., Eielson, C., Horowitz, M., Insogna, K., & Weir, E. (1996). Tumor necrosis factor-alpha induces transcription of the colony-stimulating factor 1 gene in murine osteoblasts. J. Cell Physiol, 168, 199-208.
  32.  Eielson, C., Kaplan, D. L., Mitnick, M., Paliwal, I., & Insogna, K. (1994). Estrogen modulates parathyroid hormone-induced fibronectin production in human and rat osteoblast-like cells. Endocrinology, 135, 1639-1644. doi:doi:10.1210/en.135.4.1639
  33.  Kaplan, D. L., & Boron, W. (1994). Long-term expression of c-H-ras stimulates Na-H and Na +-dependent Cl-HCO3 exchange in NIH 3T3 fibroblasts. J. Biol. Chem, 269, 4116-4124.
Edited Books
  1. Kaplan, D. (Ed.). (2016). The Initiation of DNA Replication in Eukaryotes [Book]. Springer.
    Retrieved from http://www.springer.com/us/book/9783319246949
    This is a 26 chapter book, and the ISBN number is 978-3-319-24696-3. I am the sole editor.
Invited Book Chapters
  1. Kaplan, D. L., & Bruck, I. (2010). Methods to Study How Replication Fork Helicases Unwind DNA. In Mohamed M. Abdelhaleem (Ed.), Helicases (pp. 127-136). Humana Press, Inc.
Refereed Book Chapters
  1. Dhingra, N., & Kaplan, D. (2016). Introduction to Eukaryotic DNA Replication Initiation. In Kaplan, D (Ed.), The Initiation of DNA Replication in Eukaryotes (pp. 30). Springer.
    Retrieved from http://www.springer.com/us/book/9783319246949
Invited Reviews
  1. Kaplan, D. L. (1990). Immunology 1989. Yale Journal of Biology and Medicine, 63, 201.
Presentations

Invited Presentations at Conferences
For invited presentations at conferences, 92.9% were international, 7.1% were regional in scope.

  1. Kaplan, D., Bruck, I., Dhingra, N., & Colbert, M. (presented 2016, August). Melting at a eukaryotic replication origin requires Dpb11 binding to DNA. Presentation at FASEB Conference on Yeast Chromosome Structure, Replication, and Segregation, FASEB, Snowmass, Colorado. (International) Retrieved from https://secure.faseb.org/FASEB/Meetings/SummrConf/programs/11730.pdf
  2. Kaplan, D. (presented 2015, March). The Dbf4-Cdc7 kinase promotes Mcm2-7 ring opening to allow for single-stranded DNA extrusion and helicase assembly. Presentation at DNA Replication and Recombination, Keystone, Whistler, British Columbia, Canada. (International) Retrieved from http://www.keystonesymposia.org/15X3
  3. Kaplan, D. L. (presented 2013, March). Cdc45 ssDNA interaction is important for stalling the helicase during replication stress. Presentation at Keystone Symposium on DNA Replication and Recombination, Keystone, Alberta, Canada. (International)
  4. Kaplan, D. L. (presented 2012, July). "Cdc45 ssDNA interaction is important for stalling the helicase during replication stress.". Presentation at FASEB Conference on Yeast Chromosone Structure, Replication, and Segregation, FASEB, Steamboat Springs, Colorado. (International)
  5. Kaplan, D. L. (presented 2011, September). "Sld2 and Sld3 inhibits GINS binding to Mcm2-7, and this inhibition is alleviated by origin single-stranded DNA.". Presentation at "Eukaryotic DNA Replication and Genome Maintenance", Cold Spring Harbor Conference, Cold Spring Harbor, NY. (International)
  6. Kaplan, D. L. (presented 2011, June). "Insights into the Initiation of DNA Replication.". Presentation at Yale University, Yale University, New Haven, Connecticut. (International)
  7. Kaplan, D. L. (presented 2009, September). Dbf4-Cdc7 phosphorylates a serine residue of Mcm2 required for cell growth. Presentation at "Eukaryotic DNA Replication and Genome Maintenance", Cold Spring Harbor Conference, Cold Spring Harbor, NY. (International)
  8. Kaplan, D. L. (presented 2009, March). DDK phosphorylation of Mcm2 is essential for budding yeast viability. Presentation at Southeast Regional Yeast Meeting 2009, Southeast Regional Yeast Meeting, Nashville, TN. (Regional)
  9. Kaplan, D. L. (presented 2008, July). DDK and S-CDK action at the Mcm2-7 complex. Presentation at DNA Replication and Genome Integrity, Salk Institute Conference, La Jolla, California. (International)
  10. Kaplan, D. L. (presented 2007, September). The Mcm4,6,7 subunits exhibit distinct and conserved biochemical properties. Presentation at Eukaryotic DNA Replication and Genome Maintenance, Cold Spring Harbor Conference, Cold Spring Harbor, NY. (International)
  11. Kaplan, D. L. (presented 2004). Twin DNA Pumps of a Hexameric Helicase Provide Power to Simultaneously Melt Two Duplexes. Presentation at Gordon Research Conference, Newport, Rhode Island "Nucleic Acids", Gordon Research Conferences, Newport, Rhode Island. (International)
  12. Kaplan, D. L. (presented 2003). RuvA Is a Sliding Collar that Protects Holliday Junctions from Unwinding while Promoting Branch Migration.". Presentation at 2003 FASEB Summer Research Conference"Helicases: Structure, Function and Roles in Human Disease", FASEB, Saxtons River, Vermont. (International)
  13. Kaplan, D. L. (presented 1999). The 3'-tail of a Forked-Duplex Sterically Determines Whether One or Two DNA Strands Pass Through the Central Channel of a Replication Fork Helicase. Presentation at Workshop at Instituto Juan March de Estudios e Investigaciones: Madrid, Spain, Juan March Institute, Madrid, Spain. (International)
  14. Kaplan, D. L. (presented 1994). Tumor necrosis factor-alpha induces transcription of the colony-stimulating factor 1 gene in murine osteoblasts. Presentation at American Society for Bone and Mineral Research Conference, American Society for Bone and Mineral Research, Kansas City, Kansas. (International)

Refereed Presentations at Conferences
For refereed presentations at conferences, 100.0% were international in scope.

  1. Bruck, I., & Kaplan, D. (presented 2015). The Dbf4-Cdc7 kinase promotes Mcm2-7 ring opening to allow for single-stranded DNA extrusion and helicase assembly. Poster presentation at Cold Spring Harbor Conference on DNA replication and genome maintenance, Cold Spring Harbor, Cold Spring Harbor, NY. (International)
  2. Kaplan, D., Dhingra, N., Smith, S., Wetz, S., & Ning, B. (presented 2014, July). Dpb11 functions like Sld2 or Sld3 to regulate helicase assembly. Poster presentation at Yeast Chromosome Structure, Replication and Segregation, FASEB, Steamboat Springs, Colorado. (International)
  3. Bruck, I., & Kaplan, D. L. (presented 2013, September). The Replication Initiation Protein Sld2 Regulates Helicase Assembly. Poster presentation at Eukaryotic DNA Replication and Genome Maintenance, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY. (International)
  4. Dhingra, N., Ning, B., Smith, S., & Kaplan, D. L. (presented 2013, September). Dpb11 binds to Mcm2-7 and single-stranded DNA. Poster presentation at Cold Spring Harbor Conference on DNA replication and genome maintenance, Cold Spring Harbor, Cold Spring Harbor, NY. (International)
  5. Kaplan, D. L., & Bruck, I. (presented 2011). Trading places at a Replication Origin: GINS competes with Sld3 for binding to Mcm2-7 and Cdc45. Poster presentation at 2011 Keystone Conference "DNA Replication and Recombination", Keystone, Keystone, Colorado. (International)
  6. Kaplan, D. L. (presented 2010, August). A model for Sld3 recruitment of Cdc45 to Mcm2-7 involving a single-stranded DNA switch. Poster presentation at FASEB Summer Research Conference Yeast Chromosome Structure, Replication, and Segregation, FASEB, Carefree, Arizona. (International)
  7. Kaplan, D. L. (presented 2003). Mcm4,6,7 Uses 'Pump in Ring' Mechanism to Unwind DNA by Steric Exclusion and Actively Translocate Along a Duplex. Poster presentation at 2003 Cold Spring Harbor Conference: "DNA Replication", Cold Spring Harbor, Cold Spring Harbor, New York. (International)
  8. Kaplan, D. L. (presented 2002). Studies of the RecFOR proteins. Poster presentation at Keystone Symposium "Molecular Mechanisms of DNA Replication and Recombination", Keystone, Keystone, Colorado. (International)
  9. Kaplan, D. L. (presented 1998). DnaB from Thermus aquaticus Unwinds Forked Duplex DNA with an Asymmetric Tail Length Dependence. Poster presentation at Keystone Symposium, "Molecular Mechanisms of DNA Replication and Recombination", Keystone, Taos, New Mexico. (International)
  10. Kaplan, D. L. (presented 1991). LiCl and Retinoic Acid Synergistically Induce Differentiation of WEHI-3B Myelomonocytic Leukemic Cells. Poster presentation at American Association for Cancer Research, American Association for Cancer Research, Houston, Texas. (International)
  11. Kaplan, D. L. (presented 1991). Long-term expression of c-H-ras stimulates Na-H and Na+-dependent Cl-HCO3 exchange in NIH 3T3 fibroblasts. Poster presentation at FASEB Conference/American Physiological Society, FASEB. (International)

Refereed Presentations at Symposia
For refereed presentations at symposia, 100.0% were regional in scope.

  1. Kaplan, D. L. (presented 2014). The replication initiation protein Sld2 regulates helicase assembly. In 2014 FSU Life Sciences Symposium. Poster presentation at the meeting of Florida State University, Tallahassee, Florida. (Regional)

Invited Lectures and Readings of Original Work
For invited lectures and readings of original work, 9.1% were international, 63.6% were national, 27.3% were state in scope.

  1. Kaplan, D. (2016, September). Insights into the Initiation of Eukaryotic DNA Replication. Delivered at University of Georgia, Athens, Georgia. (National)
  2. Kaplan, D. L. (2015, April). Insights into the Initiation of DNA Replication. Delivered at University of Florida Genetics Institute, Gainesville, Florida. (National)
  3. Kaplan, D. L. (2012, June). Insights into the Initiation of DNA Replicaiton. Delivered at University of Massachusetts, Dartmouth, Dartmouth, Massachusetts. (National) Department of Chemistry and Biochemistry.
  4. Kaplan, D. L. (2012, June). Insights into the Initiation of DNA Replication. Delivered at University of Illinois, College of Medicine, Peoria, Peoria, Illinois. (National) Department of Cancer Biology and Pharmacology.
  5. Kaplan, D. L. (2012, June). Insights into the Initiation of DNA Replication. Delivered at Tulane University, New Orleans, Louisiana. (National) Department of Pathology.
  6. Kaplan, D. L. (2012, January). Insights into the Initiation of DNA Replication. Delivered at Rice University, Houston, Texas. (State)
  7. Kaplan, D. L. (2011, September). Insights into the Initiation of DNA Replication. Delivered at Rockefeller University, New York, NY. (State)
  8. Kaplan, D. L. (2011, April). Insights into the Initiation of DNA Replication. Delivered at University of Minnesota, Minneapolis, Minnesota. (State)
  9. Kaplan, D. L. (2010, October). Insights into the Initiation of DNA Replication. Delivered at Indiana University, Medical Sciences Program, School of Medicine, Bloomington, Indiana. (National)
  10. Kaplan, D. L. (2010, September). Insights into the Initiation of DNA Replication. Delivered at University of California at Santa Barbara, Biomolecular Science and Engineering Program, Santa Barbara, California. (National)
  11. Kaplan, D. L. (2008, July). Mechanism and Function of Replication Fork Helicases. Delivered at Cambridge University, Department of Pharmacology, Cambridge, England. (International)

 

 

 

 

 

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