Professor of Biochemistry
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University of Health Sciences
Istanbul, Turkey
Phone: +90 506 458 0271
E-mail: ytutar@cumhuriyet.edu.tr
Education
Postdoc | 2003-2005 | Biochemistry and Genetics | National Institute of Health, NIDDK |
Postdoc | 2002-2003 | Molecular Biology and Biochemistry | Rutgers University |
Graduate PhD | 1998-2003 | Biochemistry | Texas Tech University |
Graduate MSc | 1996-1998 | Biochemistry and Biophysics | Oregon State University |
Under Graduate | 1990–1994 | Chemistry | Cumhuriyet University |
Biography
Dr. Yusuf TUTAR obtained his M.Sc. and Ph.D. at Oregon State University and Texas Tech University respectively. He pursued his postdoctoral study at National Institutes of Health (NIH/NIDDK), USA. His research focuses on Biochemistry, Biophysics, Genetics, and Molecular Biology with specialization in the fields of protein structure-function, protein folding, prion, microrna, pseudogenes, molecular cancer, proteomics, genomics, protein expression and characterization by spectroscopic and calorimetric methods. Dr. Tutar currently continue his research on drug design at University of Health Sciences, Istanbul, Turkey.
Research Interest
- Molecular Cancer Research and epigenetic (RT-PCR and Microarray).
- Micro RNA, pseudogenes, and transfection.
- Prion, translation termination in eukaryotes, and transcription initiation in prokaryotes.
- Investigating structure-function relationship of biological macromolecules with biochemical, biophysical, genetics and molecular biological methods.
- Recombinant DNA technology, molecular sub-cloning, transformation and protein expression.
- Drug design, docking, molecular dynamics.
- Nanoparticles for drug targeting.
- Protein purification (Heat shock, Catabolite repressor and S100P proteins) and characterisation (Spectroscopy: Fluorescence, Luminescence, CD, FTIR; Calorimetry: Nano DSC and ITC; Chromatography: HPLC and FPLC; Other techniques: MALDI-TOF, GC, SPR)
Scientific Activities
Employment History
Prof. Dr. | 2017-Current | Biochemistry Division, Faculty of Pharmacy, University of Health Sciences |
Prof. Dr. | 2013-2017 | Biochemistry Division, Faculty of Pharmacy, Cumhuriyet University |
Associate Prof. | 2012-2013 | Biochemistry Division, Faculty of Pharmacy, Cumhuriyet University |
Associate Prof. | 2008-2012 | Biochemistry Division, Faculty of Medicine (Adjunct) Cumhuriyet University |
Assistant Prof. | 2005–2008 | Biochemistry Department, Faculty of Science, Cumhuriyet University |
TA/RA | 1998–2003 | Biochemistry Department, Texas Tech University |
Publications
- Tumor Targeting of Polymeric Nanoparticles Conjugated with Peptides, Saccharides,and Small Molecules for Anticancer Drugs, Current Pharmaceutical Design, 2017, 23, 1-9
- Bayram B, Özgür A,Tutar L,Tutar Y.
- Anti-Cancer Activities of Manganese Based Photoactivatable CO-Releasing Complexes (PhotoCORMs) with Benzimidazole Derivative Ligands. Transition Metal Chem., 2017, In Press
- Üstün E., Özgür A., Coskun KA, Demir S., Özdemir İ., Tutar Y.
- Structure-Function Based Drug Design for Cancer Therapeutics Current Pharmaceutical Biotechnology, 2016, 17,14, 1 Tutar Y.
- Design, Synthesis, and evaluation of Heat Shock Protein 90 Inhibitors In Human Breast Cancer and Its Metastasis Current Pharmaceutical Biotechnology, 20016 17,:14, 2-17. Gümüş M, Özgür, A, Tutar L, Koca İ, Tutar Y.
- Regulation of oncogenic genes by Micro RNAs and pseudogenes in human lung cancer. Tutar Y, Özgür A, Tutar E, Tutar L, Pulliero A, Izzotti A. Biomed Pharmacother. 2016 Aug 20;83: 1182-1190
- Co-Releasing Properties and Anti-Cancer Activities of Novel Manganese Complexes with Imidazole/Benzimidazole Ligands. Journal of Coordination Chemistry, 2016 Üstün E., Özgür A., Coskun KA, Demir S., Özdemir I., Tutar Y.
- Design and synthesis of pyrimidinyl acyl thioureas as novel Hsp90 inhibitors in invasive ductal breast cancer and its bone metastasis. Eur J Med Chem, 2016:122:280-290. Koca İ, Özgür A, Er M, Gümüş M, Açikalin Coşkun K, Tutar Y.
- Heat Shock Protein 90 Inhibition in Cancer Drug Discovery: From Chemistry to Futural Clinical Applications. Anticancer Agents in Medicinal Chemistry, 2015. [Epub ahead of print]. Ozgur A,Tutar Y. Therapeutic Targeting of microRNAs in Cancer: Future Perspectives. Drug Development Research, 2015. [Epub ahead of print] Tutar L, Tutar E, Ozgur A, Tutar Y.
- A Novel Approach to Inhibit Heat Shock Response as Anticancer Strategy by Coumarine Compounds Containing Thiazole Skeleton. Anticancer Agents in Medicinal Chemistry, 2015. [Epub ahead of print]
- PMID: 25846761. Koca I, Gumus M, Ozgur A, Disli A, Tutar Y.
- Isolation and characterization of Heat Shock Protein 100 from Toxoplasma gondii RH Strain. Experimental Parasitology, 2015 Feb 26;153:91-97. doi: 10.1016/j.exppara.2015.02.007. [Epubahead of print] PMID:25728232 Coskun KA, Tutar Y.
- Acyl Thiourea Derivatives Containing Pyrazole Ring Selective Targeting of Human Aurora Kinases in Breast and Bone Cancer. Letters in Drug Design & Discovery Vol. 12, 1, 2015. Ozgur A, Yenidunya E, Koca İ, Tutar Y.
- Tumor Targeting of Polymeric Nanoparticles Conjugated with Peptides, Saccharides,and Small Molecules for Anticancer Drugs, Current Pharmaceutical Design, 2017, 23, 1-9
- Bayram B, Özgür A,Tutar L,Tutar Y.
- Anti-Cancer Activities of Manganese Based Photoactivatable CO-Releasing Complexes (PhotoCORMs) with Benzimidazole Derivative Ligands. Transition Metal Chem., 2017, In Press
- Üstün E., Özgür A., Coskun KA, Demir S., Özdemir İ., Tutar Y.
- Structure-Function Based Drug Design for Cancer Therapeutics Current Pharmaceutical Biotechnology, 2016, 17,14, 1 Tutar Y.
- Design, Synthesis, and evaluation of Heat Shock Protein 90 Inhibitors In Human Breast Cancer and Its Metastasis Current Pharmaceutical Biotechnology, 20016 17,:14, 2-17. Gümüş M, Özgür, A, Tutar L, Koca İ, Tutar Y.
- Regulation of oncogenic genes by MicroRNAs and pseudogenes in human lung cancer. Tutar Y, Özgür A, Tutar E, Tutar L, Pulliero A, Izzotti A. Biomed Pharmacother. 2016 Aug 20;83:1182-1190
- Co-Releasing Properties and Anti-Cancer Activities of Novel Manganese Complexes with Imidazole/Benzimidazole Ligands. Journal of Coordination Chemistry, 2016 Üstün E., Özgür A., Coskun KA, Demir S., Özdemir I., Tutar Y.
- Design and synthesis of pyrimidinyl acyl thioureas as novel Hsp90 inhibitors in invasive ductal breast cancer and its bone metastasis. Eur J Med Chem, 2016:122:280-290. Koca İ, Özgür A, Er M, Gümüş M, Açikalin Coşkun K, Tutar Y.
- Heat Shock Protein 90 Inhibition in Cancer Drug Discovery: From Chemistry to Futural Clinical Applications. Anticancer Agents in Medicinal Chemistry, 2015. [Epub ahead of print]. Ozgur A,Tutar Y.
- Therapeutic Targeting of microRNAs in Cancer: Future Perspectives. Drug Development Research, 2015. [Epub ahead of print] Tutar L, Tutar E, Ozgur A, Tutar Y.
- A Novel Approach to Inhibit Heat Shock Response as Anticancer Strategy by Coumarine Compounds Containing Thiazole Skeleton. Anticancer Agents in Medicinal Chemistry, 2015. [Epub ahead of print] PMID: 25846761. Koca I, Gumus M, Ozgur A, Disli A, Tutar Y.
- Isolation and characterization of Heat Shock Protein 100 from Toxoplasma gondii RH Strain. Experimental Parasitology, 2015 Feb 26;153:91-97. doi: 10.1016/j.exppara.2015.02.007. [Epubahead of print] PMID:25728232Coskun KA, Tutar Y.
- Acyl Thiourea Derivatives Containing Pyrazole Ring Selective Targeting of Human Aurora Kinases in Breast and Bone Cancer. Letters in Drug Design & Discovery Vol. 12, 1, 2015. Ozgur A, Yenidunya E, Koca İ, Tutar Y.
- Prion; Mechanism and Function-Editorial. Current Pharmaceutical Biotechnology, 2014, Vol. 15, No. 11. Tutar Y.
- Regulation of Heat Shock Proteins by miRNAs in Human Breast Cancer. MicroRNA Vol. 3, No.2, 2014. Ozgur A, Tutar L, Tutar Y.
- Heat Shock Protein 90 Inhibitors in Oncology. Current Proteomics.2014 July;11 (2):1-9. Aykut O, Tutar Y.
- Controlled Release and Drug Delivery in Diseases-Editorial. Protein and Peptide Letters. 2014, 21 (11):1. Tutar Y.
- miRNA and Cancer;computational and experimental approaches Curr Pharm Biotechnol. 2014, 15 (5):429. Tutar Y.
- miRNA and Cancer; an overview. Curr Pharm Biotechnol. 2014, 15 (5):430-437. Tutar L, Tutar E, Tutar Y.
- Synthesis, molecular docking, and antitumoral activity of alnustone-like compounds against estrogen receptor alpha-positive human breast cancer. 2014, DOI: 10.3906/kim-1408-72. Küçükoğlu K, Seçinti H, Özgür A, Seçen H, Tutar Y.
- The Relation Between microRNA 221, 222, 146b and p27Kip1 Protein mRNA Secretions and ClinicopathologicalParameters in Thyroid Cancers and the Alteration of miRNA Secretion in the presence of Hashimoto Thyroiditis. Experimental and Clinical Endocrinology & Diabetes.2014 Mar;122(3):137-143. Acibucu F, Dokmetas S, Tutar Y., Elagoz S, Kilicli F.
- Dynamic Fluctuations Provide the Basis of a Conformational Switch Mechanism in Apo Cyclic AMP Receptor Protein. Plos Computational Biology. 2013 Jul;9(7): e1003141. Fas B.A., Tutar Y., Haliloglu T.
- Important Clinical Applications of Protein Based Nanoparticles. Current Proteomics. Vol 10 (4) 334-340, 2013. Ergul M, Ergul M, Tutar Y.
- Isolation and Identification of Free Living Environmental Isolates of Amoebae Samples in Sivas, Turkey.
- Biomed Research International. Volume 2013 (2013), Article ID 675145. Coskun A., Celik S, Tutar L, Elaldi N, Tutar Y.