john-jack-patrick-vanden-heuvel
John (Jack) Patrick Vanden Heuvel, PhD
Professor of Molecular Toxicology
  • Penn State University
    Pennsylvania,USA
    Phone: (814) 863-8532
    E-mail:  jpv2@psu.edu; jackvh.cas.psu.edu

     

Education

BS. 1986 University  of  Wisconsin-Madison  (Pharmacology/Toxicology)
PhD. 1991 University of Wisconsin-Madison (Environmental Toxicology)
Post doc 1991-1993 National Institutes of Health Sciences (Molecular Toxicology)

Biography

Dr. John (Jack) P. Vanden Heuvel received his B.S. degree in Pharmacology and Toxicology in 1986 and his PhD in Environmental Toxicology in 1991, both from the University of Wisconsin at Madison. Dr. Vanden Heuvel’s post-doctoral training was at the National Institutes of Environmental Sciences (NIEHS) in Research Triangle Park, NC in the Laboratory of Biochemical Risk Assessment. His first academic position was as an Assistant Professor at Purdue University in the School of Pharamcy, Department of Pharmacology and Toxicology. He joined the faculty of Penn State in 1997. He is currently a Professor, Department of Veterinary and Biomedical Sciences, Penn State University and serves as coordinator of the Undergraduate Toxicology Program. Since 2004 Dr. Vanden Heuvel has served as Co-Director for the Center for Excellence in Nutrigenomics and is a member of the Executive Committee of the NIH-funded Penn State Clinical and Translational Sciences Institute (CTSI).


Research Interest

Dr. Vanden Heuvel’s research interest is in understanding the molecular biology of nuclear receptors, in particular the peroxisome proliferator-activated receptors (PPARs). PPARs are targets of several clinically-relevant drugs, pollutants and nutrients and have broad interest in many disciplines including toxicology, cancer biology and nutrition. Although focus is still on the pharmacology and toxicology of PPARs, a great deal of the current studies of the Vanden Heuvel lab focus on omega-3 fatty acids and other bioactive molecules found in the diet. Dr. Vanden Heuvel and associates have been utilizing their research tools in molecular biology and gene expression to understand the role of nuclear receptors in the beneficial effects of dietary fatty acids in preventing cancer, obesity and diabetes. Research funding comes from the National Institute of Health (NIH), American Institute of Cancer Research, Susan B. Komen Funds and several pharmaceutical and trade organizations. To date, Dr. Vanden Heuvel has produced 100 peer-reviewed publications, been the lead editor and author of 3 books and written 24 book chapters. Due to the number of requests for research services from pharmaceutical companies, in 2005 Dr. Vanden Heuvel and a colleague founded Indigo Biosciences, Inc.  Originally developed as a contract research organization, many small to mid-sized companies have utilized Indigo Bioscience’s expertise to test their compounds for nuclear receptor activity. Beginning in 2007, the primary focus has been on developing a line of nuclear receptor assay kits. Dr. Vanden Heuvel serves as the Chief Scientific Officer and uses his expertise in drug discovery and toxicology to assist in research services and product development.

Scientific Activities

Professional Experience
1987-1991 Research Assistant and NIEHS trainee, Environmental Toxicology Center, University of Wisconsin-Madison
1993-1996 Assistant Professor, Department of Pharmacology and Toxicology, Purdue University, West Lafayette, IN
1997-2000 Assistant Professor, Department of Veterinary Science and Center for Molecular Toxicology,Penn State University, University Park, PA
2000-2006 Associate Professor, Department of Veterinary Science and Center for Molecular Toxicology, Penn State University, University Park, PA
2004-07,
2012-present
Program Coordinator, Toxicology Undergraduate Program, Penn State University, University Park, PA
2004-present Co-Director, Center for Excellence in Nutrigenomics, Penn State niversity, University Park, PA
2005-present Co-Founder and Chief Scientific Officer, Indigo Biosciences, Inc., 1981 Pine Hall Road, State College PA
2006-present Professor, Department of Veterinary and Biomedical Sciences and Center for Molecular Toxicology and Carcinogenesis, Penn State University, University Park, PA

Publications

Articles published in refereed journals

  1. Smith, R.W., Coleman, J.D., Thompson, J.T., and Vanden Heuvel, J.P. (2016) Therapeutic potential of GW501516 and the role of Peroxisome Proliferator-Activated Receptor β/δ and B-Cell Lymphoma 6 in inflammatory signaling in human pancreatic cancer cells. Biochem Biophys Reports, In press.
  2. Hannon, D.B., Thompson, J.T., Khoo, C., Juturu, V., and Vanden Heuvel, J.P. (2016) Effects of cranberry extracts on gene expression in THP-1 cells. Food Science and Nutrition, In Press
  3. Vanden Heuvel, J. P., Bullenkamp, J., and Reproducibility Project: Cancer Biology (2016) Registered report: Systematic identification of genomic markers of drug sensitivity in cancer cells, Elife 5:e13620. DOI: 10.7554/eLife.13620
  4. Vanden Heuvel, J. P., Thompson, J. T., Albrecht, P., Mandetta, D., Kamerow, H., and Ford, J. P. (2015) Differential nucleobase protection against 5-fluorouracil toxicity for squamous and columnar cells: implication for tissue function and oncogenesis, Invest New Drugs 33, 1003-1011.
  5. Harris Jackson K, West SG, Vanden Heuvel JP, Jonnalagadda SS, Ross AB, Hill AM, Grieger JA, Lemieux SK, and Kris-Etherton PM. (2014) Effects of whole and refined grains in a weight-loss diet on markers of metabolic syndrome in individuals with increased waist circumference: a randomized controlled-feeding trial. Am J Clin Nutr 100, 577-586.
  6. Roussell, M., Hill, A., Gaugler, T., West, S., Ulbrecht, J., Vanden Heuvel, J.P., Gillies, P., and Kris- Etherton, P.M. Effects of a DASH-like diet containing lean beef on vascular health. Journal of Human Hypertension. J Hum Hypertens 28, 600-605.
  7. Paul, K. B., Thompson, J. T., Simmons, S. O., Vanden Heuvel, J. P., and Crofton, K. M. (2013) Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors, Toxicol In Vitro 27, 2049- 2060.
  8. Eser, P. O., Vanden Heuvel, J. P., Araujo, J., and Thompson, J. T. (2013) Marine- and plant-derived ω-3 fatty acids differentially regulate prostate cancer cell proliferation, Mol Clin Oncol 1, 444-452.
  9. Vanden Heuvel, J. P. (2013) Comment on "associations between PFOA, PFOS and changes in the expression of genes involved in cholesterol metabolism in humans" by Fletcher et al., Environment International 57-58 (2013) 2-10, Environ Int 61, 150-153.
  10. Coleman, J.D.,  Thompson, J.T., Smith III, R.W., Prokopczyk, B. and Vanden Heuvel, J.P. 2013. Role of Peroxisome Proliferator-Activated Receptor and B-Cell Lymphoma-6 in Regulation of Genes Involved in Metastasis and Migration in Pancreatic Cancer Cells,” PPAR Research, vol. 2013, Article ID 121956, 11 pages, 2013.  doi:10.1155/2013/121956
  11. Belda, B. J., Thompson, J. T., Sinha, R., Prabhu, K. S. and Vanden Heuvel, J. P. (2012) The dietary fatty acid 10E12Z-CLA induces epiregulin expression through COX-2 dependent PGF(2α) synthesis in adipocytes. Prostaglandins Other Lipid Mediat 99, 30-37.
  12. Percival, S. S., Vanden Heuvel, J. P., Nieves, C. J., Montero, C., Migliaccio, A. J. and Meadors, J. (2012) Bioavailability of Herbs and Spices in Humans as Determined by ex vivo Inflammatory Suppression and DNA Strand Breaks. J Am Coll Nutr 31, 288-294
  13. Vanden Heuvel, J. P., Belda, B. J., Hannon, D. B., Kris-Etherton, P. M., Grieger, J. A., Zhang, J. and Thompson, J. T. (2012) Mechanistic examination of walnuts in prevention of breast cancer. Nutr Cancer 64, 1078-1086
  14. Roussell M. A., A. M. Hill, T. L. Gaugler, S. G. West, J. P. Vanden Heuvel, P. Alaupovic, P. J. Gillies, and P. M. Kris-Etherton. 2012. Beef in an Optimal Lean Diet study: effects on lipids, lipoproteins, and apolipoproteins. Am J Clin Nutr 95:9-16.
  15. Gillies P. J., S. K. Bhatia, L. A. Belcher, D. B. Hannon, J. T. Thompson, and J. P. Vanden Heuvel. 2012. Regulation of inflammatory and lipid metabolism genes by eicosapentaenoic acid-rich oil. J Lipid Res 1679- 1689.
  16. Bidinotto, L. T., Cicco, R. L., Vanegas, J. E., Santucci-Pereira, J., Vanden Heuvel, J. P., Washington, S., Aliaga, C., Xu, H., Russo, I. H., Manni, A., El-Bayoumy, K. and Russo, J. (2012) Fish Oil Alters Tamoxifen- Modulated Expression of mRNAs That Encode Genes Related to Differentiation, Proliferation, Metastasis, and Immune Response in Rat Mammary Tumors. Nutr Cancer 64, 991-999.
  17. Zhang J., P. M. Kris-Etherton, J. T. Thompson, D. B. Hannon, P. J. Gillies, and J. P. Heuvel. 2012. Alpha-linolenic acid increases cholesterol efflux in macrophage-derived foam cells by decreasing stearoyl CoA desaturase 1 expression: evidence for a farnesoid-X-receptor mechanism of action. J Nutr Biochem 23:400-
    409.
  18. Vanden Heuvel J. P. 2012. Nutrigenomics and Nutrigenetics of ω3 Polyunsaturated Fatty Acids. Prog Mol Biol Transl Sci 108:75-112.
  19. Skulas-Ray A. C., P. M. Kris-Etherton, W. S. Harris, J. P. Vanden Heuvel, P. R. Wagner, and S. G. West. 2011. Dose-response effects of omega-3 fatty acids on triglycerides, inflammation, and endothelial function in healthy persons with moderate hypertriglyceridemia. Am J Clin Nutr 93:243-252.
  20. Zhang J., S. Cai, B. R. Peterson, P. M. Kris-Etherton, and J. P. Heuvel. 2011. Development of a cell-based, high-throughput screening assay for cholesterol efflux using a fluorescent mimic of cholesterol. Assay Drug Dev Technol 9:136-146.
  21. Hegde S., N. Kaushal, K. C. Ravindra, C. Chiaro, K. T. Hafer, U. H. Gandhi, J. T. Thompson, J. P. van den Heuvel, M. J. Kennett, P. Hankey, R. F. Paulson, and K. S. Prabhu. 2011. Δ12-prostaglandin J3, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice. Blood 118:6909-6919.
  22. Manni A., H. Xu, S. Washington, C. Aliaga, A. Das, T. Cooper, J. P. Richie, B. Prokopczyk, A. Calcagnotto, N. Trushin, J. P. Van den Heuvel, C. Hamilton, L. M. Demers, J. Liao, M. F. Verderame, and K. El- Bayoumy. 2011. The Effects of Tamoxifen and Fish Oil on Mammary Carcinogenesis in Polyoma Middle T Transgenic Mice. Horm Cancer 2:249-259.
  23. Skulas-Ray A. C., P. M. Kris-Etherton, D. L. Teeter, C. Y. Chen, J. P. Vanden Heuvel, and S. G. West. 2011. A High Antioxidant Spice Blend Attenuates Postprandial Insulin and Triglyceride Responses and Increases Some Plasma Measures of Antioxidant Activity in Healthy, Overweight Men. J Nutr 141:1451-1457.
  24. Zhang J., P. M. Kris-Etherton, J. T. Thompson, D. B. Hannon, P. J. Gillies, and J. P. Vanden Heuvel. 2011. Alpha-linolenic acid increases cholesterol efflux in macrophage-derived foam cells by decreasing stearoyl CoA desaturase 1 expression: evidence for a farnesoid-X-receptor mechanism of action. J Nutr Biochem .
  25. Belda B. J., J. T. Thompson, P. O. Eser, and J. P. Vanden Heuvel. 2011. 10E12Z CLA alters adipocyte differentiation and adipocyte cytokine expression and induces macrophage proliferation. J Nutr Biochem .
  26. Raman P., B. L. Kaplan, J. T. Thompson, J. P. Vanden Heuvel, and N. E. Kaminski. 2011. 15-deoxy- delta12,14 prostaglandin J2-glycerol ester, a putative metabolite of 2-arachidonyl glycerol, activates peroxisome proliferator activated receptor gamma. Mol Pharmacol 80:201-209.
  27. Zhang J., J. A. Grieger, P. M. Kris-Etherton, J. T. Thompson, P. J. Gillies, J. A. Fleming, and J. P. Vanden Heuvel. 2011. Walnut oil increases cholesterol efflux through inhibition of stearoyl CoA desaturase 1 in THP-1 macrophage-derived foam cells. Nutr Metab (Lond) 8:61.
  28. Omiecinski C. J., J. P. Vanden Heuvel, G. H. Perdew, and J. M. Peters. 2011. Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicities. Toxicol Sci 120 Suppl 1:S49-S75.
  29. Lee Y., and J. P. Vanden Heuvel. 2010. Inhibition of macrophage adhesion activity by 9trans,11trans-conjugated linoleic acid. J Nutr Biochem 21:490-497.
  30. Zhang J., P. M. Kris-Etherton, J. T. Thompson, and J. P. Heuvel. 2010. Effect of pistachio oil on gene expression of IFN-induced protein with tetratricopeptide repeats 2: a biomarker of inflammatory response. Mol Nutr Food Res 54 Suppl 1:S83-S92.
  31. Vanden Heuvel J. P. 2009. Cardiovascular Disease-related Genes and Regulation by Diet. Curr Atheroscler Rep  11:448-455.
  32. Velliquette R. A., P. J. Gillies, P. M. Kris-Etherton, J. W. Green, G. Zhao, and J. P. Vanden Heuvel. 2009. Regulation of human stearoyl-CoA desaturase by omega-3 and omega-6 fatty acids: Implications for the dietary management of elevated serum triglycerides. J Clin Lipidol 3:281-288.
  33. Lee Y., J. T. Thompson, and J. P. Vanden Heuvel. 2009. 9E,11E-Conjugated Linoleic Acid Increases Expression of the Endogenous Antiinflammatory Factor, Interleukin-1 Receptor Antagonist, in RAW 264.7 Cells. J Nutr 139:1861-1866.
  34. Lee Y., J. T. Thompson, A. R. de Lera, and J. P. Vanden Heuvel. 2009. Isomer-specific effects of conjugated linoleic acid on gene expression in RAW 264.7. J Nutr Biochem 20:848-59, 859.e1-5.
  35. Gopinathan L., D. B. Hannon, J. M. Peters, and J. P. Vanden Heuvel. 2009. Regulation of peroxisome proliferator-activated receptor-alpha by MDM2. Toxicol Sci 108:48-58.
  36. Bionaz M., C. R. Baumrucker, E. Shirk, J. P. Vanden Heuvel, E. Block, and G. A. Varga. 2008. Characterization of madin-darby bovine kidney cell line for peroxisome proliferator-activated receptors: temporal response and sensitivity to fatty acids. J Dairy Sci 91:2808-2813.
  37. Davis P. A., M. Jenab, J. P. Vanden Heuvel, T. Furlong, and S. Taylor. 2008. Tree nut and peanut consumption in relation to chronic and metabolic diseases including allergy. J Nutr 138:1757S-1762S.
  38. Vunta H., B. J. Belda, R. J. Arner, C. Channa Reddy, J. P. Vanden Heuvel, and K. Sandeep Prabhu. 2008. Selenium attenuates pro-inflammatory gene expression in macrophages. Mol Nutr Food Res 52:1316-1323.
  39. Gopinathan L., D. B. Hannon, R. W. Smith Iii, J. M. Peters, and J. P. Vanden Heuvel. 2008. Regulation of peroxisome proliferator-activated receptors by e6-associated protein. PPAR Res 2008:746935.
  40. Dancu M. B., D. E. Berardi, J. P. Vanden Heuvel, and J. M. Tarbell. 2007. Atherogenic Endothelial Cell eNOS and ET-1 Responses to Asynchronous Hemodynamics are Mitigated by Conjugated Linoleic Acid. Ann Biomed Eng 35:1111-1119.
  41. Burns K. A., and J. P. Vanden Heuvel. 2007. Modulation of PPAR activity via phosphorylation. Biochim Biophys Acta 1771:952-960.
  42. Vanden Heuvel J. P. 2007. The PPAR resource page. Biochim Biophys Acta 1771:1108-1112.
  43. Coleman J. D., K. S. Prabhu, J. T. Thompson, P. S. Reddy, J. M. Peters, B. R. Peterson, C. C. Reddy, and J. P. Vanden Heuvel. 2007. The oxidative stress mediator 4-hydroxynonenal is an intracellular agonist of the nuclear receptor peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta). Free Radic Biol Med  42:1155-1164.
  44. Woods C. G., J. P. Heuvel, and I. Rusyn. 2007. Genomic profiling in nuclear receptor-mediated toxicity. Toxicol Pathol 35:474-494.
  45. Rockwell C. E., N. T. Snider, J. T. Thompson, J. P. Vanden Heuvel, and N. E. Kaminski. 2006. Interleukin-2 suppression by 2-arachidonyl glycerol is mediated through peroxisome proliferator-activated receptor gamma independently of cannabinoid receptors 1 and 2. Mol Pharmacol 70:101-111.
  46. Tien E. S., D. B. Hannon, J. T. Thompson, and J. P. Vanden Heuvel. 2006. Examination of Ligand-Dependent Coactivator Recruitment by Peroxisome Proliferator-Activated Receptor-alpha (PPARalpha). PPAR Res 2006:69612.
  47. Gray J. P., J. W. Davis, L. Gopinathan, T. L. Leas, C. A. Nugent, and J. P. Vanden Heuvel. 2006. The ribosomal protein rpL11 associates with and inhibits the transcriptional activity of peroxisome proliferator- activated receptor-alpha. Toxicol Sci 89:535-546.
  48. Vanden Heuvel J. P., J. T. Thompson, S. R. Frame, and P. J. Gillies. 2006. Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: a comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha, -beta, and -gamma, liver X receptor-beta, and retinoid X receptor-alpha. Toxicol Sci 92:476-489.
  49. Zhao G., T. D. Etherton, K. R. Martin, J. P. Vanden Heuvel, P. J. Gillies, S. G. West, and P. M. Kris- Etherton. 2005. Anti-inflammatory effects of polyunsaturated fatty acids in THP-1 cells. Biochem Biophys Res Commun 336:909-917.
  50. Gray J. P., K. A. Burns, T. L. Leas, G. H. Perdew, and J. P. Vanden Heuvel. 2005. Regulation of peroxisome proliferator-activated receptor alpha by protein kinase C. Biochemistry 44:10313-10321.
  51. Dancu M. B., D. E. Berardi, J. P. Vanden Heuvel, and J. M. Tarbell. 2004. Asynchronous shear stress and circumferential strain reduces endothelial NO synthase and cyclooxygenase-2 but induces endothelin-1 gene expression in endothelial cells. Arterioscler Thromb Vasc Biol 24:2088-2094.
  52. Vanden Heuvel J. P. 2004. Diet, fatty acids, and regulation of genes important for heart disease. Curr Atheroscler Rep 6:432-440.
  53. Tien E. S., J. W. Davis, and J. P. Vanden Heuvel. 2004. Identification of the CREB-binding protein/p300- interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator. J Biol Chem 279:24053-24063.
  54. Bility M. T., J. T. Thompson, R. H. McKee, R. M. David, J. H. Butala, J. P. Vanden Heuvel, and J. M. Peters. 2004. Activation of mouse and human peroxisome proliferator-activated receptors (PPARs) by phthalate monoesters. Toxicol Sci 82:170-182.
  55. B  Rees C., S. D. McCormick, J. P. Vanden Heuvel, and W. Li. 2003. Quantitative PCR analysis of CYP1A induction in Atlantic salmon (Salmo salar). Aquat Toxicol 62:67-78.
  56. Gray J. P., T. L. Leas, E. Obert, D. Brown, G. C. Clark, and J. P. Vanden Heuvel. 2003. Evidence of aryl hydrocarbon receptor ligands in Presque Isle Bay of Lake Erie. Aquat Toxicol 64:343-358.
  57. Mueller C., V. Weaver, J. P. Vanden Heuvel, A. August, and M. T. Cantorna. 2003. Peroxisome proliferator-activated receptor gamma ligands attenuate immunological symptoms of experimental allergic asthma. Arch Biochem Biophys 418:186-196.
  58. Sumanasekera W. K., E. S. Tien, J. W. Davis, R. Turpey, G. H. Perdew, and J. P. Vanden Heuvel. 2003. Heat shock protein-90 (Hsp90) acts as a repressor of peroxisome proliferator-activated receptor-alpha (PPARalpha) and PPARbeta activity. Biochemistry 42:10726-10735.
  59. DeGrazia M. J., J. Thompson, J. P. Heuvel, and B. R. Peterson. 2003. Synthesis of a high-affinity fluorescent PPARgamma ligand for high-throughput fluorescence polarization assays. Bioorg Med Chem 11:4325-4332.
  60. Tien E. S., J. P. Gray, J. M. Peters, and J. P. Vanden Heuvel. 2003. Comprehensive gene expression analysis of peroxisome proliferator-treated immortalized hepatocytes: identification of peroxisome proliferator- activated receptor alpha-dependent growth regulatory genes. Cancer Res 63:5767-5780.
  61. Sumanasekera W. K., E. S. Tien, R. Turpey, J. P. Vanden Heuvel, and G. H. Perdew. 2003. Evidence that peroxisome proliferator-activated receptor alpha is complexed with the 90-kDa heat shock protein and the hepatitis virus B X-associated protein 2. J Biol Chem 278:4467-4473.
  62. Khan S. A., and J. P. Vanden Heuvel. 2003. Role of nuclear receptors in the regulation of gene expression by dietary fatty acids (review). J Nutr Biochem 14:554-567.
  63. Vanden Heuvel J. P., D. Kreder, B. Belda, D. B. Hannon, C. A. Nugent, K. A. Burns, and M. J. Taylor. 2003. Comprehensive analysis of gene expression in rat and human hepatoma cells exposed to the peroxisome proliferator WY14,643. Toxicol Appl Pharmacol 188:185-198.
  64. Yu Y., P. H. Correll, and J. P. Vanden Heuvel. 2002. Conjugated linoleic acid decreases production of pro- inflammatory products in macrophages: evidence for a PPAR gamma-dependent mechanism. Biochim Biophys Acta 1581:89-99.
  65. Kehrer J. P., S. S. Biswal, E. La, P. Thuillier, K. Datta, S. M. Fischer, and J. P. Vanden Heuvel. 2001. Inhibition of peroxisome-proliferator-activated receptor (PPAR)alpha by MK886. Biochem J 356:899-906.
  66. Vanden Heuvel J. P., and J. M. Peters. 2001. Biology of the PPAR Family of Receptors. Comments on Toxicology  7:233-257.
  67. Kumar M. B., P. Ramadoss, R. K. Reen, J. P. Vanden Heuvel, and G. H. Perdew. 2001. The Q-rich subdomain of the human Ah receptor transactivation domain is required for dioxin-mediated transcriptional activity. J Biol Chem 276:42302-42310.
  68. Moya-Camarena S. Y., J. P. Van den Heuvel, and M. A. Belury. 1999. Conjugated linoleic acid activates peroxisome proliferator-activated receptor alpha and beta subtypes but does not induce hepatic peroxisome proliferation in Sprague-Dawley rats. Biochim Biophys Acta 1436:331-342.
  69. Moya-Camarena S. Y., J. P. Vanden Heuvel, S. G. Blanchard, L. A. Leesnitzer, and M. A. Belury. 1999. Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARalpha. J Lipid Res 40:1426-1433.
  70. Vanden Heuvel J. P. 1999. Peroxisome proliferator-activated receptors: a critical link among fatty acids, gene expression and carcinogenesis. J Nutr 129:575S-580S.
  71. Vanden Heuvel J. P. 1999. Peroxisome proliferator-activated receptors (PPARS) and carcinogenesis. Toxicol Sci 47:1-8.
  72. Houseknecht K. L., J. P. Vanden Heuvel, S. Y. Moya-Camarena, C. P. Portocarrero, L. W. Peck, K. P. Nickel, and M. A. Belury. 1998. Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fatty fa/fa rat. Biochem Biophys Res Commun 244:678-682.
  73. Meyer B. K., M. G. Pray-Grant, J. P. Vanden Heuvel, and G. H. Perdew. 1998. Hepatitis B virus X- associated protein 2 is a subunit of the unliganded aryl hydrocarbon receptor core complex and exhibits transcriptional enhancer activity. Mol Cell Biol 18:978-988.
  74. Kane M. D., J. P. Vanden Heuvel, G. E. Isom, and R. D. Schwarz. 1998. Differential expression of group I metabotropic glutamate receptors (mGluRs) in the rat pheochromocytoma cell line PC12: role of nerve growth factor and ras. Neurosci Lett 252:1-4.
  75. Martinez E., D. D. Moore, E. Keller, D. Pearce, J. P. Vanden Heuvel, V. Robinson, B. Gottlieb, P. MacDonald, S. Simons, E. Sanchez, and M. Danielsen. 1998. The Nuclear Receptor Resource: a growing family. Nucleic Acids Res 26:239-241.
  76. Belury M. A., S. Y. Moya-Camarena, H. Sun, E. Snyder, J. W. Davis, M. L. Cunningham, and J. P. Vanden Heuvel. 1998. Comparison of dose-response relationships for induction of lipid metabolizing and growth regulatory genes by peroxisome proliferators in rat liver. Toxicol Appl Pharmacol 151:254-261.
  77. Vanden Heuvel J. P., P. Holden, J. Tugwood, C. Ingle, W. Yen, N. Galjart, and W. F. Greenlee. 1998. Identification of a novel peroxisome proliferator responsive cDNA isolated from rat hepatocytes as the zinc- finger protein ZFP-37. Toxicol Appl Pharmacol 152:107-118.
  78. Perdew G. H., H. Wiegand, J. P. Vanden Heuvel, C. Mitchell, and S. S. Singh. 1997. A 50 kilodalton protein associated with raf and pp60(v-src) protein kinases is a mammalian homolog of the cell cycle control  protein cdc37. Biochemistry 36:3600-3607.
  79. Sterchele P. F., H. Sun, R. E. Peterson, and J. P. Vanden Heuvel. 1996. Regulation of peroxisome proliferator-activated receptor-alpha mRNA in rat liver. Arch Biochem Biophys 326:281-289.
  80. Selmin O., G. W. Lucier, G. C. Clark, A. M. Tritscher, J. P. Vanden Heuvel, J. A. Gastel, N. J. Walker, T. R. Sutter, and D. A. Bell. 1996. Isolation and characterization of a novel gene induced by 2,3,7,8- tetrachlorodibenzo-p-dioxin in rat liver. Carcinogenesis 17:2609-2615.
  81. Vanden Heuvel J. P. 1996. Perfluorodecanoic acid as a useful pharmacologic tool for the study of peroxisome proliferation. Gen Pharmacol 27:1123-1129.
  82. Sewall C. H., D. A. Bell, G. C. Clark, A. M. Tritscher, D. B. Tully, J. Vanden Heuvel, and G. W. Lucier. 1995. Induced gene transcription: implications for biomarkers. Clin Chem 41:1829-1834.
  83. Sewall C. H., N. Flagler, J. P. Vanden Heuvel, G. C. Clark, A. M. Tritscher, R. M. Maronpot, and G. W. Lucier. 1995. Alterations in thyroid function in female Sprague-Dawley rats following chronic treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol 132:237-244.
  84. Sterchele P. F., J. P. Vanden Heuvel, J. W. Davis, E. Shrago, J. Knudsen, and R. E. Peterson. 1994. Induction of hepatic acyl-CoA-binding protein and liver fatty acid-binding protein by perfluorodecanoic acid in rats. Lack of correlation with hepatic long-chain acyl-CoA levels. Biochem Pharmacol 48:955-966.
  85. Vanden Heuvel J. P., G. C. Clark, M. C. Kohn, A. M. Tritscher, W. F. Greenlee, G. W. Lucier, and D. A. Bell. 1994. Dioxin-responsive genes: examination of dose-response relationships using quantitative reverse transcriptase-polymerase chain reaction. Cancer Res 54:62-68.
  86. Vanden Heuvel J. P., G. C. Clark, A. Tritscher, and G. W. Lucier. 1994. Accumulation of polychlorinated dibenzo-p-dioxins and dibenzofurans in liver of control laboratory rats. Fundam Appl Toxicol 23:465-469.
  87. Vanden Heuvel J. P., P. F. Sterchele, D. J. Nesbit, and R. E. Peterson. 1993. Coordinate induction of acyl- CoA binding protein, fatty acid binding protein and peroxisomal beta-oxidation by peroxisome proliferators. Biochim Biophys Acta 1177:183-190.
  88. Vanden Heuvel J. P., F. L. Tyson, and D. A. Bell. 1993. Construction of recombinant RNA templates for use as internal standards in quantitative RT-PCR. Biotechniques 14:395-398.
  89. Vanden Heuvel J. P., G. C. Clark, C. L. Thompson, Z. McCoy, C. R. Miller, G. W. Lucier, and D. A. Bell. 1993. CYP1A1 mRNA levels as a human exposure biomarker: use of quantitative polymerase chain reaction to measure CYP1A1 expression in human peripheral blood lymphocytes. Carcinogenesis 14:2003-2006.
  90. Vanden Heuvel J. P., and G. Lucier. 1993. Environmental toxicology of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans. Environ Health Perspect 100:189-200.
  91. Vanden Heuvel J. P., B. I. Kuslikis, and R. E. Peterson. 1992. Covalent binding of perfluorinated fatty acids to proteins in the plasma, liver and testes of rats. Chem Biol Interact 82:317-328.
  92. Kuslikis B. I., J. P. Vanden Heuvel, and R. E. Peterson. 1992. Lack of evidence for perfluorodecanoyl- or perfluorooctanoyl-coenzyme A formation in male and female rats. J Biochem Toxicol 7:25-29.
  93. Vanden Heuvel J. P., J. W. Davis, R. Sommers, and R. E. Peterson. 1992. Renal excretion of perfluorooctanoic acid in male rats: inhibitory effect of testosterone. J Biochem Toxicol 7:31-36.
  94. Vanden Heuvel J. P., B. I. Kuslikis, E. Shrago, and R. E. Peterson. 1991. Inhibition of long-chain acyl-CoA synthetase by the peroxisome proliferator perfluorodecanoic acid in rat hepatocytes. Biochem Pharmacol 42:295-302.
  95. Vanden Heuvel J. P., B. I. Kuslikis, M. J. Van Rafelghem, and R. E. Peterson. 1991. Tissue distribution, metabolism, and elimination of perfluorooctanoic acid in male and female rats. J Biochem Toxicol 6:83-92.
  96. Davis J. W., J. P. Vanden Heuvel, and R. E. Peterson. 1991. Effects of perfluorodecanoic acid on de novo fatty acid and cholesterol synthesis in the rat. Lipids 26:857-859.
  97. Vanden Heuvel J. P., B. I. Kuslikis, M. J. Van Rafelghem, and R. E. Peterson. 1991. Disposition of perfluorodecanoic acid in male and female rats. Toxicol Appl Pharmacol 107:450-459.
  98. Vanden Heuvel J. P., M. J. Van Rafelghem, L. A. Menahan, and R. E. Peterson. 1989. Isolation and purification of perfluorodecanoic and perfluorooctanoic acids from rat tissues. Lipids 24:526-531.
  99. Van Rafelghem M. J., J. P. Vanden Heuvel, L. A. Menahan, and R. E. Peterson. 1988. Perfluorodecanoic acid and lipid metabolism in the rat. Lipids 23:671-678.
Book Chapters
  1. Vanden Heuvel J. P. 2016. Peroxisome Proliferator-Activated Receptors: Biological and Toxicological Importance. In Comprehensive Toxicology. Elsevier Ltd, Kidlington, United Kingdom. Submitted May 9, 2016
  2. Vanden Heuvel J. P. 2016. Receptor theory and the ligand-macromolecule complex,. In Comprehensive Toxicology. Elsevier, Ltd, Kidlington, United Kingdom., Submitted February 5, 2016
  3. Vanden Heuvel J. P. 2016. Xenobiotic Receptor-Mediated Carcinogenesis. In Comprehensive Toxicology. Elsevier, Ltd, Kidlington, United Kingdom. Submitted March 7, 2016
  4. Vanden Heuvel J. P., and J. M. Peters. 2010. Peroxisome proliferator-activated receptors, p. 145-167. In Comprehensive Toxicology. Elsevier Ltd, Kidlington, United Kingdom.
  5. Vanden Heuvel J. P. 2010. Receptor theory and the ligand-macromolecule complex, p. 27-50. In Comprehensive Toxicology. Elsevier, Ltd, Kidlington, United Kingdom.
  6. Vanden Heuvel J. P. 2010. Receptor-mediated carcinogenesis, p. 349-369. In Comprehensive Toxicology. Elsevier, Ltd, Kidlington, United Kingdom.
  7. Vanden Heuvel J. P. 2009. Toxicity of Peroxisome Proliferators, p. 333-344. In General and Applied Toxicology. John Wiley & Sons, Ltd, West Sussex, United Kingdom.
  8. Vanden Heuvel J. P., H. Mehendale, and J. Manautou. 2006. Liver toxicity and cancer, p. 137-182. In Assessing the human health risks of trichloroethylene: Key scientific issues. The National Academies Press, Washington, DC .
  9. Vanden Heuvel J. P. 2006. Peroxisome proliferators and liver cancer, p. 418-425. In Assessing the human health risks of trichloroethylene: Key scientific issues. The National Academies Press, Washington, DC .
  10. Vanden Heuvel J. P. 2006. Gene Expression control at the mRNA level. Chapter 1. Overview, p. 3-10. In Regulation of gene expression. Human Press, Totowa, N.J..
  11. Vanden Heuvel J. P. 2006. Gene Expression control at the mRNA level. Chapter 2: Messenger RNA accumulation, p. 11-30. In Regulation of gene expression. Human Press, Totowa, N.J..
  12. Vanden Heuvel J. P. 2006. Gene Expression control at the mRNA level. Chapter 3: Transcript profiling, p. 31-48. In Regulation of gene expression. Human Press, Totowa, N.J..
  13. Vanden Heuvel J. P. 2006. Gene Expression control at the mRNA level. Chapter 4: Transcriptional regulation of gene expression, p. 49-104. In Regulation of gene expression. Human Press, Totowa, N.J..
  14. Vanden Heuvel J. P. 2006. Gene Expression control at the mRNA level. Chapter 5: Posttranscriptional processing of messenger RNA, p. 105-146. In Regulation of gene expression. Human Press, Totowa, N.J..
  15. Vanden Heuvel J. P. 2005. Nuclear Receptor: Peroxisome proliferator-activated receptors, p. 286-289. In McGraw-Hill Yearbook of Science & Technology. McGraw-Hill, New York, N.Y., U.S.A..
  16. Vanden Heuvel J. P. 2002. Xenobiotic receptor systems: Introduction and Overview, p. 81-117. In Cellular and molecular toxicology. Elsevier Science, Amsterdam, The Netherlands.
  17. Vanden Heuvel J. P. 2002. Introduction to Molecular Toxicology, p. 1-12. In Comprehensive toxicology: Cellular and molecular toxicology. Elsevier Science, Amsterdam, The Netherlands.
  18. Vanden Heuvel J. P. 2002. Receptor Theory and the Ligand-Macromolecule Complex, p. 29-56. In Comprehensive toxicology: Cellular and molecular toxicology. Elsevier Science, Amsterdam, The Netherlands.
  19. Vanden Heuvel J. P. 2002. Control of Gene Expression, p. 57-106. In Comprehensive toxicology: Cellular and molecular toxicology. Elsevier Science, Amsterdam, The Netherlands.
  20. Vanden Heuvel J. P., and J. M. Peters. 2002. Peroxisomes, peroxisome proliferators and peroxisome proliferator-activated receptors, p. 133-158. In Comprehensive toxicology: Cellular and molecular toxicology. Elsevier Science, Amsterdam, The Netherlands.
  21. Vanden Heuvel J. P. 2001. Nuclear Receptor: Peroxisome proliferator-activated receptors, p. 286-289. In McGraw-Hill Yearbook of Science & Technology. McGraw-Hill, New York, N.Y., U.S.A..
  22. Belury M. A., and J. P. Vanden Heuvel. 1999. Modulation of diabetes by conjugated linoleic acid, p. 404- 413. In Advances in Conjugated Linoleic Acid Research . AOCS Press, Champaign, IL.
  23. Vanden Heuvel J. P. 1998. Approaches for the identification of xenobiotic-inducible genes, p. 217-235. In Toxicant-receptor interactions and modulation of gene expression . Lippincott-Raven Press, Philadelphia, PA.
  24. Vanden Heuvel J. P. 1997. Analysis of gene expression, p. 41-98. In PCR Applications in Molecular Toxicology . CRC Press, Boca Raton, FL.
  25. Vanden Heuvel J. P. 1997. Cloning by PCR, p. 121-162. In PCR Applications in Molecular Toxicology . CRC Press, Boca Raton, FL.
  26. Vanden Heuvel J. P. 1997. General molecular biology techniques, p. 177-212. In PCR Applications in Molecular Toxicology . CRC Press, Boca Raton, FL.
Books Edited
  1. 2006. Regulation of gene expression: Molecular mechanisms. Eds., G. H. Perdew, J. P. Vanden Heuvel, and J. M. Peters. Humana Press, Totowa, N.J..
  2. 2002. Cellular and molecular toxicology. Eds., J. P. Vanden Heuvel, G. H. Perdew, W. B. Mattes, and W. F. Greenlee. Elsevier Science, Amsterdam, The Netherlands.
  3. Vanden Heuvel J. P., W. B. Mattes, J. C. Corton, D. A. Bell, and G. Pittman. 1998. PCR Protocols in Molecular Toxicology. Eds., J. P. Vanden Heuvel. CRC Press, Boca Raton, FL

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