Vincenzo Cuomo
Vincenzo Cuomo
Professor
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  • :0039/0649912480

Department of Physiology and Pharmacology
Sapienza University of Rome
Italy

Education

1971 Degree in Medicine and Surgery (full score) University of Napoli, Italy
1971-1973 Fellowship at the Institute of Pharmacology University of Bari (Italy)
1976 PhD in Hygiene and Preventive Medicine University of Bari, Italy

 

Biography

Born in Anacapri (Naples), Italy, Dec. 3, 1947. Graduated in Medicine in 1971, Vincenzo Cuomo is Professor of Pharmacology at the University of Rome“Sapienza”, Italy. Author of more than 250 publications on scientific journals and of several books and book chapters in the field of Neuropharmacology and Neurotoxicology.
Prof. Cuomo has carried out part of his research activity in Switzerland (Institut fur Toxicologie der Universitat, Zurich) and in USA (Dept. of Environmental Health Sciences, The Johns Hopkins University, Baltimore MD). Scientific appointments and Committees: Secretary General of the Italian Society of Toxicology (1986/92), Temporary Adviser of WHO and Member of the Steering Committee of WHO/IPCS (Neurotoxicity assessment 1989/95), Member of the Executive Committee of EUROTOX (1991/93) and Italian Society of Neurosciences (1993/96), Secretary General of the Italian Society of Pharmacology (1997/1999), President of the Italian Society of Pharmacology (1999/2003). He has been, or he still is member of the Editorial Board of international journals: Neurotoxicol. Teratol., Neurosci. Res. Commun., Pharmacol. Res., Toxicol. Lett..
Prof Cuomo’s research activity has been mainly addressed to the evaluation of neurobehavioural, neurochemical and electrophysiological changes produced in rats by the developmental exposure to psychotherapeutic agents, drugs of abuse, and environmental chemicals. More recently he has explored the effects of chemicals influencing the endocannabinoid system in animal models of psychiatric disorders. All these researches have been funded by WHO, EPA, Italian Ministry of Education, National Research Council, Italian Ministry of Health.

Research Interest

Author of more than 250 publications on scientific journals and of several books and book chapters in the field of Neuropharmacology and Neurotoxicology. Dr Cuomo’s research activity has been mainly addressed to the evaluation of neurobehavioural, neurochemical and electrophysiological changes produced in rats by the developmental exposure to psychotherapeutic agents, drugs of abuse, and environmental chemicals. More recently he has explored the effects of chemicals influencing the endocannabinoid system in animal models of psychiatric disorders. In particular, he has explored the role of endocannabinoids and related lipid signals in the modulation of cognitive functions, feeding behaviour, anxiety and mood tone.

All these researches have been funded by WHO, EPA, Italian Ministry of Education, National Research Council, Italian Ministry of Health.

Professional Activities:

Other scientific activities and Professional Memberships

1986-1992

Secretary General of the Italian Society of Toxicology

1989-1995

Member of the Steering Committee of WHO/IPCS (Collaborative Study on Neurotoxicology Assessment)

1989-1993

Member of the European Interlaboratory Study Group on Behavioral Teratology

1991-1993

Member of the Executive Committee of EUROTOX (European Society of Toxicology)

1993-1996

Member of the Executive Committee of the Italian Society of Neurosciences

1995-1997

Member of the Executive Committee of the Italian Society of Pharmacology

1997-1999

General Secretary of the Italian Society of Pharmacology

1999-2003

President of the Italian Society of Pharmacology

2006-2010

Member of National University Council

2001-present

Director PhD School of Toxicology

2001-2006

Director Department of Pharmacology of Natural Substances and General Physiology

2008-present

Member of the Scientific Committee of the School of Pharmacy, Tor Vergata Univ., Rome

Work Experience:

Assistant Professor, Institute of Pharmacology, University of Bari (Italy) 1973-1980
Associate Professor, Institute of Pharmacology,University of Bari (Italy) 1980-1985
Full Professor of Pharmacology, Institute of Pharmacology, University of Bari (Italy) 1986-2001
Full Professor of Pharmacology, Dept. of Physiology and Pharmacology “V. Erspamer” Sapienza University of Rome 2001-present
Visiting Professor, Institute of Toxicology, University of Zurich (Switzerland) and Dept. of Environmental Health Sciences, Johns Hopkins University (Baltimore, USA) 1979-1983
 

Publications

  1. CAMPOLONGO P, MORENA M, SCACCIANOCE S, TREZZA V, CHIAROTTI F, SCHELLING G, CUOMO V, ROOZENDAAL B. Novelty-induced emotional arousal modulates cannabinoid effects on recognition memory and adrenocortical activity. Neuropsychopharmacol. 2013, 8(7):1276-86.
  2. TRABACE L, ZOTTI M, MORGESE MG, TUCCI P, COLAIANNA M, SCHIAVONE S, AVATO P, CUOMO V. Estrous cycle affects the neurochemical and neurobehavioral profile of carvacrol-treated female rats. Toxicol Appl Pharmacol 2011, 255(2):169-75.
  3. GAETANI S, FU J, CASSANO T, DIPASQUALE P, ROMANO A, RIGHETTI L, CIANCI S, LACONCA L, GIANNINI E, SCACCIANOCE S, MAIRESSE J, CUOMO V, PIOMELLI D, The fat-induced satiety factor OEA suppresses feeding through central release of oxytocin, J Neurosci 2010, 30(24):8096–8101.
  4. CAMPOLONGO P, TREZZA V, PALMERY M, TRABACE L, CUOMO V Developmental exposure to cannabinoids causes subtle and enduring neurofunctional alterations, Int Rev Neurobiol 2009 85:117-33
  5. GAETANI S, DIPASQUALE P, ROMANO A, RIGHETTI L, CASSANO T, PIOMELLI D, CUOMO V The endocannabinoid system as a target for novel anxiolytic and antidepressant drugs. Int Rev Neurobiol 2009, 85:57-72
  6. CAMPOLONGO P, ROOZENDAAL B, TREZZA V, HAUER D, SCHELLING G, MCGAUGH JL, CUOMO V. Endocannabinoids in the rat basolateral amygdala enhance memory consolidation: involvement of the glucocorticoid system. Proc Natl Acad Sci USA 2009, 106(12):4888-93
  7. SCHWARTZ GJ, FU J, ASTARITA G, XIAOSONG L, GAETANI S, CAMPOLONGO P, CUOMO V, PIOMELLI D The lipid messenger OEA links dietary fat intake to satiety. Cell Metab 2008, 8(4):281-8
  8. TREZZA V, CAMPOLONGO P, CASSANO T, MACHEDA T, DIPASQUALE P, CARRATÙ MR, GAETANI S, CUOMO V Effects of perinatal exposure to delta-9-tetrahydrocannabinol on the emotional reactivity of the offspring: a longitudinal behavioral study in Wistar rats. Psychopharmacology 2008, 198(4):529-37
  9. CASTALDO P, MAGI S, GAETANI S, CASSANO T, FERRARO L, ANTONELLI T, AMOROSO S, CUOMO V. Prenatal exposure to the cannabinoid receptor agonist WIN 55,212-2 increases glutamate uptake through overexpression of GLT1 and EAAC1 glutamate transporter subtypes in rat frontal cerebral cortex. Neuropharmacology 2007, 53(3):369-78
  10. GOBBI G, BAMBICO FR, MANGIERI R, BORTOLATO M, CAMPOLONGO P, SOLINAS M, CASSANO T, MORGESE MG, DEBONNEL G, DURANTI A, TONTINI A, TARZIA G, MOR M, TREZZA V, GOLDBERG SR, CUOMO V, PIOMELLI D, Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis. Proc Natl Acad Sci USA 2005, 102(51):18620-5
  11. CAMPOLONGO P, TREZZA V, CASSANO T, GAETANI S, MORGESE MG, UBALDI M, SOVERCHIA L, ANTONELLI T, FERRARO L, MASSI M, CICCOCIOPPO R, CUOMO V. Perinatal exposure to delta-9-tetrahydrocannabinol causes enduring cognitive deficits associated with alteration of cortical gene expression and neurotransmission in rats. Addict Biol 2007, 12(3-4): 485-95
  12. COSTA LG, STEARDO L, CUOMO V Structural effects and neurofunctional sequelae of developmental exposure to psychotherapeutic drugs: experimental and clinical aspects. Pharmacol Rev 2004, 56(1):103-47
  13. SARTIANI L, CERBAI E, LONARDO G, DE PAOLI P, TATTOLI M, CAGIANO R, CARRATU’ MR, CUOMO V, MUGELLI A. Prenatal exposure to carbon monoxide affects postnatal cellular electrophysiological maturation of the rat heart: a potential substrate for arrhythmogenesis in infancy. Circulation 2004, 109(3):419-23
  14. KATHURIA S, GAETANI S, FEGLEY D, VALINO F, DURANTI A, TONTINI A, MOR M, TARZIA G, LA RANA G, CALIGNANO A, GIUSTINO A, TATTOLI M, PALMERY M, CUOMO V, PIOMELLI D, Modulation of anxiety through blockade of anandamide hydrolysis, Nat Med 2003, 9(1):76-81
  15. MEREU G., FÀ M., FERRARO L., CAGIANO R., ANTONELLI T., TATTOLI M., GHIGLIERI V., TANGANELLI S., GESSA G.L., CUOMO V. Prenatal exposure to a cannabinoid agonist produces memory deficits linked to dysfunction in hippocampal long-term potentiation and glutamate release, Proc Natl Acad Sci USA 2003, 100(8):4915-20

 

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