Chao Cai, PhD
Clinical Assistant Professor
  • Department of Clinical Pharmacy and Outcomes Sciences
    University of South Carolina, USA
    Phone: (803) 777-2333


2001-2003 Master of Applied Statistics University of Pittsburgh, Pennsylvania, USA
2013 Ph.D. in Biostatistics University of South Carolina, Columbia, SC, USA



Dr. Cai is a Clinical Assistant Professor of Clinical Pharmacy and Outcomes Sciences, at the University of South Carolina with over 15 years of statistical consulting and statistical methodology development experience in health sciences including academia, industry and government. Dr. Cai received a master’s degree in Applied Statistics from University of Pittsburgh in 2003 and Ph.D. in Biostatistics from University of South Carolina in 2013.


Research Interest

Mixture cure model, Causal mediation model, Adherence and Persistence, Cost-effectiveness analysis, Statistical methods in clinical trials, Observational Studies, Pharmacoepidemiology, Pharmacoeconomics.

Scientific Activities:

Teaching Experience
2020-Present Clinical Assistant Professor, Department of Clinical Pharmacy and Outcomes Sciences University of South Carolina, Columbia, South Carolina, USA
2014-2019 Research Associate, Department of Psychology University of South Carolina, Columbia, South Carolina, USA
2011-2014 Biostatistician, Division of Acute Disease Epidemiology, Bureau of Disease Control SC Department of Health and Environmental Control, Columbia, South Carolina, USA
2010-2011 Research Associate, Department of Epidemiology and Biostatistics University of South Carolina, Columbia, South Carolina, USA
2007-2009 Operations Analyst Cox Communications, Santa Barbara, California, USA
2006 Lead Statistician National Childhood Cancer Research (CureSearch), Los Angeles, California, USA
2003-2006 Biostatistician University of Pittsburgh Cancer Institute (UPMC), Pittsburgh, Pennsylvania, USA
Honors & Awards
2015 Best Poster, International Meeting of the Psychometric Society (IMPS)
Advancing Quantitative Methodology in Behavioral Sciences
2013 Outstanding Biostatistics Student, University of South Carolina, USA
2013 Recognition of Junior Invited Speaker at ASA
2002 Scholarship of Faculty of Arts and Science, University of Pittsburgh, USA



  1. Shealy K, Phillips C, Bzowyckyj A, Gupta V, Guyton J, et al. (2020) Endocrine Pharmacotherapy Education in United States Colleges and Schools of Pharmacy. J Am College Clin Pharm.
  2. Wang Y, Zhang J, Cai C, Lu W, Tang Y (2020) Semiparametric estimation for proportional hazards mixture cure model allowing non-curable competing risk. J Statistical Planning Inference 211: 171-189.
  3. Fairchild A, Cai C, McDaniel H, Shi D, Gottschall A, et al. (2019) Evaluating A method to Estimate Mediation Effects with Discrete-Time Survival Outcomes. Fron Psychol 10: 740.
  4. Cai C, Wang S, Lu W, Zhang J (2014) NPHMC: An R-Package for estimating sample size of proportional hazards mixture cure models. Comput Methods Programs Biomed 113: 290-300.
  5. Cai C, Zou Y, Peng Y, Zhang J (2012) smcure: An R-Package for estimating semiparametric mixture cure models. Comput Methods Programs Biomed 108: 1255-1260.
  6. Tarhini A, Kirkwood M, Gooding W, Cai C, Agarwala S (2007) Durable Complete Responses With High-Dose Bolus Interleukin-2 in Patients With Metastatic Melanoma Who Have Experienced Progression After Biochemotherapy. J ClinOncol 25: 3802-3807.
  7. Akhavan A, Keith D, Bastacky I, Cai C, Wang Y, et al. (2007) The proportion of cores with high-grade prostatic intraepithelial neoplasia on extended-pattern needle biopsy is significantly associated with prostate cancer on site-directed repeat biopsy. BJU Int 99: 765-769.
  8. Patel H, Stoller R, Auber M, Potter D, Cai C, et al. (2006) Phase II Study of Rubitecan an Oral Camptothecin in Patients with Advanced Colorectal Cancer Who Have Failed Previous 5-Fluorouracil based Chemotherapy. Invest New Drugs 24: 359-363.
  9. Gologan A, Bastacky S, McHale T, Yu J, Cai C, et al. (2005) Age-associated changes in Alpha-methyl CoA racemase (AMACR) expression in non-neoplastic prostatic tissues. Am J Surg Pathol 29: 1435-1441.
  10. Modugno F, Zmuda JM, Potter D, Cai C, Ziv E, et al. (2005) The Association of Estrogen Receptor Alpha Polymorphisms with Breast Cancer. Risk in Older White Women. Int J Cancer 116: 984-991.
  11. Modugno F, Zmuda JM, Potter D, Cai C, Ziv E, et al. (2005) Estrogen Metabolizing Polymorphisms and Breast Cancer Risk among Older White Women. Breast Cancer Res Treat 93: 261-270.