Professor of Periodontics
- University of Texas Health Science Center
San Antonio, Texas, USA
Phone: (210) 567-3723
E-mail: harris@uthscsa.edu
Education
Institution and Location |
Degree |
Completion Date |
Field of Study |
U. of Texas at Austin, Austin , TEXAS |
BA |
08/1965 |
Biology |
U. of Texas at Austin, Austin , TEXAS |
MS |
08/1966 |
Biochemical Embryology |
U. of Texas at Austin, Austin, TEXAS |
PHD |
08/1969 |
Molecular Embryology |
California Institute of Technology, Pasadena, California |
Postdoctoral Fellow |
06/1972 |
NIH Postdoctoral Fellowship in Chromatin Biology |
Biography
Dr. Stephen Eubank Harris have had a strong interest in gene regulation since 1965 as a graduate student, continuing at CalTech working on nucleic acid hybridization theory and practice and chromatin biology, and with Bert O’Malley working on estrogen regulation of the ovalbumin gene. From 1976 to 1983, he was director of Molecular Embryology Workgroup at NIEHS, working on androgen regulation, and cloning of androgen regulated genes. In 1983, he was appointed director of Recombinant DNA at the W. Alton Jones Cell Science Center in Lake Placid NY, continuing molecular characterization of the andogen receptor and androgen regulated growth factor genes. In 1990 a began an interests in bone and teeth molecular biology, with a focus on the Bmp2 and Bmp4 genes. This work continues today in the context of next generation sequencing tools and method to develop deeper mechanistic insights into Bmp2 action. Our paper in J. of Cell Science, Yang et al, 2013 and paper in International Journal of Oral Sciences, Rakian et al, 2013 describes many of the skills and techniques we have applied to current projects in evaluating the bone phenotypes of the conditional Bmp2 tooth, periodontium, and bone selective knock-out models. He have over 23 years experience in mouse genetic models and 50 years in molecular biology.
Research Interest
- MP signaling in bone
- Osteocyte response to mechanical stimulation
- Transgenic and other mouse models
Scientific Activities
Positions and Employment
1971 - 1971 |
Instructor, California Institute of Technology, Pasadena, CA |
1972 - 1973 |
Research Scientist Associate, Vanderbilt School of Medicine, Nashville , TN |
1973 - 1976 |
Instructor, Dept. Cell Biology, Baylor College of Medicine, Houston , TX |
1976 - 1983 |
Senior Staff Fellow, Molecular Embryology, National Institute of Environmental Health Sciences, Research Triangle Park, NC |
1983 - 1990 |
Senior Scientist, Dir. of Recombinant DNA Lab, W. Alton Jones Cell Science Center, Lake Placid , NY |
1990 - 2000 |
Associate Professor, Dept. Medicine, U. of Texas Health Science Center at San Antonio, San Antonio |
2000 - 2001 |
Professor, Department of Medicine, Div. of Endocrinology, U. of Texas Health Science Center at San Antonio, SAN ANTONIO, TX |
2002-2004 |
Professor with Full Tenure, Dept. of Oral Biology, U. of Missouri at Kansas City, Kansas City, MO |
2004 -present |
Professor and Director of Research, Dept. of Periodontics, U. of Texas Health Science Center at San Antonio, SAN ANTONIO, TX |
2005 - present |
Professor, Biomedical Engineering Program, U. of Texas at San Antonio, SAN ANTONIO, TX |
Other Experience and Professional Memberships
1985 - 1995 |
Member, Endocrine Society |
1991 - |
Member, American Society of Bone and Mineral Research |
1996 - 2010 |
AdHoc Member and Chairman, NIH Study Sections |
2004 - 2007 |
Member, Advocacy Committee, American Society of Bone and Mineral Research |
2006 - 2011 |
Standing Member, Veteran Administraton Endocrinology Study Section |
2012 – 2015 |
Board Member, Advances in Mineral Metabolism |
2004-present |
Member of the Costar/T32 Leadership Council, Postdoctoral Component |
2011-present |
Mentor of Audrey Rakian, DDS/PhD student with NIH F32 grant |
Mentorship
1974-1976 |
Postdoctoral Fellow, John Monahan, Baylor College of Medicine, Houston |
1976-1983 |
Postdoctoral Trainees, Alan Silverberg, Don Carter, Per-Erik Manson,NIEHS |
1983-1990 |
Graduate Students, PhD, Jeff Hall and ZX Rong, W. Alton Jones Cell Science Center |
1990-2002 |
Postdoctoral Fellows, Jian Q. Feng, Di Chen, and Nandini Ghosh-choudhury |
2002-2004 |
Graduate Students, Dayong Guo and Wuchen Yang, UMKC, School of Dentistry |
2004-present |
Graduate Students, Wuchen Yang, PhD, Audrey Rakian, DDS/PhD. Periodontic Postgraduate Residents, Brad Stout, Brian Alient, Peter Pedelino, Ryan Holbrook, Dimitri Villareal, Becky Neitske, Mike Rediske |
Honors
1970 |
NIH Individual Postdoctoral Fellowship, California Institute of Technology |
1992 |
Fellow, American Association for the Advancement of Science |
2000 |
Howard Hughes Institute Mini-Sabatical Fellowship, Howard Hughes Foundation_U. of Texas Health Science Center at San Antonio |
2009 |
Invited Speaker, The 3rd Global COE International Symposium, Frontiers in Bone Biology |
2012 |
Invited Speaker, International Symposium on Frontiers in Tooth Biology, Cheng-du, China |
2014 |
Invited Judge and Grant Reviewer, Bone Disease Program of Texas |
Publications
- Prideaux M, Dallas SL, Zhao N, Johnsrud ED, Veno PA, Guo D, Mishina Y, Harris SE, Bonewald LF. Parathyroid Hormone Induces Bone Cell Motility and Loss of Mature Osteocyte Phenotype through L-Calcium Channel Dependent and Independent Mechanisms PLoS One 2015 May;10(5):0125731-0125731.
- Yang W, Guo D, Harris MA, Cui Y, Gluhak-Heinrich J, Wu J, Chen XD, Skinner C, Nyman JS, Edwards JR, Mundy GR, Lichtler A, Kream BE, Rowe DW, Kalajzic I, David V, Quarles DL, Villareal D, Scott G, Ray M, Liu S, Martin JF, Mishina Y, Harris SE. Bmp2 in osteoblasts of periosteum and trabecular bone links bone formation to vascularization and mesenchymal stem cells J Cell Sci 2013 Sep;126:4085-4098.
- Rakian A, Yang WC, Gluhak-Heinrich J, Cui Y, Harris MA, Villarreal D, Feng JQ, Macdougall M, Harris SE. Bone morphogenetic protein-2 gene controls tooth root development in coordination with formation of the periodontium Int J Oral Sci 2013 Jun;5(2):75-84.
- Zhang R, Oyajobi BO, Harris SE, Chen D, Tsao C, Deng HW, Zhao M. Wnt/Beta-catenin signaling activates bone morphgenetic protein 2 expression in osteoblasts Bone 2013 Jan;52(1):145-156.
- Kalajzic I, Matthews BG, Torreggiani E, Harris MA, Divieti Pajevic P, Harris SE. In vitro and in vivo approaches to study osteocyte biology Bone 2012 Oct;.
- Yeh CK, Harris SE, Mohan S, Horn D, Fajardo R, Chun YH, Jorgensen J, Macdougall M, Abboud-Werner S, Chun YP. Hyperglycemia and xerostomia are key determinants of tooth decay in type 1 diabetic mice Lab Invest 2012 Jun;92(6):868-882.
- Yang W, Harris MA, Cui Y, Mishina Y, Harris SE, Gluhak-Heinrich J. Bmp2 is required for odontoblast differentiation and pulp vasculogenesis J Dent Res 2012 Jan;91(1):58-64.
- Werner SL, Horn D, Woodruff K, Prihoda TJ, Zimmer S, Rebel VI, Fajardo RJ, Harris M, Harris SE. Meox2Cre-mediated disruption of CSF-1 leads to osteopetrosis and osteocyte defects Bone 2012 Jan;50(1):42-53.
- Shu B, Zhang M, Xie R, Wang M, Jin H, Hou W, Tang D, Harris SE, Mishina Y, OKeefe RJ, Hilton MJ, Wang Y, Chen D. BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development J Cell Sci 2011 Oct;124:3428-3440.
- Feng J, Yang G, Yuan G, Gluhak-Heinrich J, Yang W, Wang L, Chen Z, Schulze McDaniel J, Donly KJ, Harris SE, Macdougall M, Chen S. Abnormalities in the enamel in bmp2-deficient mice Cells Tissues Organs 2011 May;194(2-4):216-221.
- Wu LA, Feng J, Wang L, Mu YD, Baker A, Donly KJ, Harris SE, MacDougall M, Chen S. Development and characterization of a mouse floxed Bmp2 osteoblast cell line that retains osteoblast genotype and phenotype Cell Tissue Res 2011 Mar;343(3):545-558.