Meiyun Fan
Meiyun Fan, MS, PhD
Associate Professor of Pathology and Laboratory Medicine

University of Tennessee Health Science Center


August, 1983 – July, 1989 Bachelor of Medicine Beijing Medical University, Beijing, P. R. China
August, 1996 - July, 1998 M.S. in Biopharmaceutical Sciences University of Arkansas for Medical Sciences
August, 1998 - December, 2000 Ph.D. in Biochemistry and Molecular Biology University of Arkansas for Medical Sciences




Research Interest

  • Identification Of Prognostic Markers In Different Subtypes Of Breast Tumors
  • Mirna And Phenotypic Switch Of Basal-Like Breast Tumor Cells (BLBC)
  • SMARCE1 And Anoikis Resistance Of Metastatic Tumor Cells


Professional Activities:

Jul. 2015 – present Associate Professor Department of Pathology and Laboratory Medicine University of Tennessee Health Science Center
Sep. 2009 -Jun. 2015 Assistant Professor Department of Pathology and Laboratory Medicine University of Tennessee Health Science Center
Oct. 2008 - Sep. 2009 Instructor Department of Pathology and Laboratory Medicine University of Tennessee Health Science Center
Sep. 2006 – Sep. 2008 Research Associate Department of Pathology and Laboratory Medicine University of Tennessee Health Science Center
Jan. 2005 - Aug. 2006    Research Assistant Professor Department of Cellular and Integrative Physiology Indiana University School of Medicine

Teaching Experience:

  • Director and main instructor(with 75% teaching load) of PATH924: Web-Based Bioinformatics and Computational Biology Tools(2012 – 2015, every fall, a 2-credit course of College of Graduate Health Sciences)
  • Mentoring graduate student presentation in PATH834 (2011-2015, every spring, a 1-credit course for College of Graduate Health Sciences)
  • Instructor for IP844_201040: Organ Systems and Disease (2010 Fall, one lecture)

Editorial Appointments:

  • Served as a reviewer for the following Journals:
  • Breast Cancer Research
  • Clinical Science
  • Journal of Experimental & Clinical Cancer Research
  • Journal of Endocrinology
  • Oncogene
  • Plos One
  • Tumor Biology



  1. Krutilina R, Sun W, Sethuraman A, Brown M, Seagroves TN, Pfeffer LM, Ignatova T, Fan M: MicroRNA-18a inhibits hypoxia-inducible factor 1-alpha activity and lung metastasis in basal breast cancers. Breast cancer research : BCR 2014, 16(4):R78.
  2. Fan M, Sethuraman A, Brown M, Sun W, Pfeffer LM: Systematic analysis of metastasis-associated genes identifies miR-17-5p as a metastatic suppressor of basal-like breast cancer. Breast cancer research and treatment 2014, 146(3):487-502.
  3. Yang CH, Yue J, Pfeffer SR, Fan M, Paulus E, Hosni-Ahmed A, Sims M, Qayyum S, Davidoff AM, Handorf CR,Pfeffer LM: MicroRNA-21 Promotes Glioblastoma Tumorigenesis by Down-regulating Insulin-like Growth Factor-binding Protein-3 (IGFBP3). The Journal of biological chemistry 2014, 289(36):25079-25087.
  4. Pfeffer LM, Li K, Fleckenstein JF, Marion TN, Diament J, Yang CH, Pfeffer SR, Fan M, Handorf E, Handorf CR: An interferon response gene signature is associated with the therapeutic response of hepatitis C patients. PloS one 2014, 9(8):e104202.
  5. Wang C, Schwab LP, Fan M, Seagroves TN, Buolamwini JK: Chemoprevention activity of dipyridamole in the MMTV-PyMT transgenic mouse model of breast cancer. Cancer prevention research 2013, 6(5):437-447.
  6. Garner JM, Fan M, Yang CH, Du Z, Sims M, Davidoff AM, Pfeffer LM: Constitutive activation of signal transducer and activator of transcription 3 (STAT3) and nuclear factor kappaB signaling in glioblastoma cancer stem cells regulates the Notch pathway. The Journal of biological chemistry 2013, 288(36):26167-26176.
  7. Fan M, Pfeffer SR, Lynch HT, Cassidy P, Leachman S, Pfeffer LM, Kopelovich L: Altered transcriptome signature of phenotypically normal skin fibroblasts heterozygous for CDKN2A in familial melanoma: relevance to early intervention. Oncotarget 2013, 4(1):128-141.
  8. Fan M, Krutilina R, Sun J, Sethuraman A, Yang CH, Wu ZH, Yue J, Pfeffer LM: Comprehensive Analysis of MicroRNA (miRNA) Targets in Breast Cancer Cells. The Journal of biological chemistry 2013, 288(38):27480-27493.
  9. Niu J, Shi Y, Tan G, Yang CH, Fan M, Pfeffer LM, Wu ZH: DNA damage induces NF-kappaB-dependent microRNA-21 up-regulation and promotes breast cancer cell invasion. The Journal of biological chemistry 2012, 287(26):21783-21795.
  10. Li K, Li NL, Wei D, Pfeffer SR, Fan M, Pfeffer LM: Activation of chemokine and inflammatory cytokine response in hepatitis C virus-infected hepatocytes depends on Toll-like receptor 3 sensing of hepatitis C virus double-stranded RNA intermediates. Hepatology 2012, 55(3):666-675.
  11. Chen H, Fan M, Pfeffer LM, Laribee RN: The histone H3 lysine 56 acetylation pathway is regulated by target of rapamycin (TOR) signaling and functions directly in ribosomal RNA biogenesis. Nucleic acids research 2012, 40(14):6534-6546.
  12. Balasubramanian S, Fan M, Messmer-Blust AF, Yang CH, Trendel JA, Jeyaratnam JA, Pfeffer LM, Vestal DJ: The interferon-gamma-induced GTPase, mGBP-2, inhibits tumor necrosis factor alpha (TNF-alpha) induction of matrix metalloproteinase-9 (MMP-9) by inhibiting NF-kappaB and Rac protein. The Journal of biological chemistry 2011, 286(22):20054-20064.
  13. Long X, Fan M, Nephew KP: Estrogen receptor-alpha-interacting cytokeratins potentiate the antiestrogenic activity of fulvestrant. Cancer biology & therapy 2010, 9(5):389-396.
  14. Yang CH, Yue J, Fan M, Pfeffer LM: IFN induces miR-21 through a signal transducer and activator of transcription 3-dependent pathway as a suppressive negative feedback on IFN-induced apoptosis. Cancer research 2010, 70(20):8108-8116.
  15. Yang CH, Fan M, Slominski AT, Yue J, Pfeffer LM: The role of constitutively activated STAT3 in B16 melanoma cells. International journal of interferon, cytokine and mediator research : IJIM 2010, 2010(2):1-7.‎
  16. Wang N, Dong Q, Li J, Jangra RK, Fan M, Brasier AR, Lemon SM, Pfeffer LM, Li K: Viral induction of the zinc finger antiviral protein is IRF3-dependent but NF-kappaB-independent. The Journal of biological chemistry 2010, 285(9):6080-6090.
  17. Rao SK, Pavicevic Z, Du Z, Kim JG, Fan M, Jiao Y, Rosebush M, Samant S, Gu W, Pfeffer LM et al: Pro-inflammatory genes as biomarkers and therapeutic targets in oral squamous cell carcinoma. The Journal of biological chemistry 2010, 285(42):32512-32521.
  18. Xin F, Li M, Balch C, Thomson M, Fan M, Liu Y, Hammond SM, Kim S, Nephew KP: Computational analysis of microRNA profiles and their target genes suggests significant involvement in breast cancer antiestrogen resistance. Bioinformatics 2009, 25(4):430-434.
  19. Du Z, Fan M, Kim JG, Eckerle D, Lothstein L, Wei L, Pfeffer LM: Interferon-resistant Daudi cell line with a Stat2 defect is resistant to apoptosis induced by chemotherapeutic agents. The Journal of biological chemistry 2009, 284(41):27808-27815.
  20. Yang CH, Murti A, Pfeffer SR, Fan M, Du Z, Pfeffer LM: The role of TRAF2 binding to the type I interferon receptor in alternative NF kappaB activation and antiviral response. The Journal of biological chemistry 2008, 283(21):14309-14316.
  21. Wei L, Fan M, Xu L, Heinrich K, Berry MW, Homayouni R, Pfeffer LM: Bioinformatic analysis reveals cRel as a regulator of a subset of interferon-stimulated genes. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2008, 28(9):541-551.
  22. Long X, Fan M, Bigsby RM, Nephew KP: Apigenin inhibits antiestrogen-resistant breast cancer cell growth through estrogen receptor-alpha-dependent and estrogen receptor-alpha-independent mechanisms. Molecular cancer therapeutics 2008, 7(7):2096-2108.
  23. Rosati SF, Williams RF, Nunnally LC, McGee MC, Sims TL, Tracey L, Zhou J, Fan M, Ng CY, Nathwani AC et al: IFN-beta sensitizes neuroblastoma to the antitumor activity of temozolomide by modulating O6-methylguanine DNA methyltransferase expression. Molecular cancer therapeutics 2008, 7(12):3852-3858.
  24. Berry NB, Fan M, Nephew KP: Estrogen receptor-alpha hinge-region lysines 302 and 303 regulate receptor degradation by the proteasome. Molecular endocrinology 2008, 22(7):1535-1551.
  25. Fan M, Rickert EL, Chen L, Aftab SA, Nephew KP, Weatherman RV: Characterization of molecular and structural determinants of selective estrogen receptor downregulators. Breast cancer research and treatment 2007, 103(1):37-44.
  26. Du Z, Wei L, Murti A, Pfeffer SR, Fan M, Yang CH, Pfeffer LM: Non-conventional signal transduction by type 1 interferons: the NF-kappaB pathway. Journal of cellular biochemistry 2007, 102(5):1087-1094.
  27. Li L, Cheng AS, Jin VX, Paik HH, Fan M, Li X, Zhang W, Robarge J, Balch C, Davuluri RV et al: A mixture model-based discriminate analysis for identifying ordered transcription factor binding site pairs in gene promoters directly regulated by estrogen receptor-alpha. Bioinformatics 2006, 22(18):2210-2216.
  28. Fan M, Yan PS, Hartman-Frey C, Chen L, Paik H, Oyer SL, Salisbury JD, Cheng AS, Li L, Abbosh PH et al: Diverse gene expression and DNA methylation profiles correlate with differential adaptation of breast cancer cells to the antiestrogens tamoxifen and fulvestrant. Cancer research 2006, 66(24):11954-11966.
  29. Jin, VX, Leu, YW, Liyanarachchi, S, Sun, H, Fan, M, Nephew, KP, Huang, TH, Davuluri, RV:Estrogen receptor α target genes: The role of integrated computational genomics and chromation immunoprecipitation microarray. International Journal of Medicine. 2006, 8(1):64-74
  30. Cheng AS, Jin VX, Fan M, Smith LT, Liyanarachchi S, Yan PS, Leu YW, Chan MW, Plass C, Nephew KP et al: Combinatorial analysis of transcription factor partners reveals recruitment of c-MYC to estrogen receptor-alpha responsive promoters. Molecular cell 2006, 21(3):393-404.
  31. Fan M, Park A, Nephew KP: CHIP (carboxyl terminus of Hsc70-interacting protein) promotes basal and geldanamycin-induced degradation of estrogen receptor-alpha. Molecular endocrinology 2005, 19(12):2901-2914.
  32. Leu YW, Yan PS, Fan M, Jin VX, Liu JC, Curran EM, Welshons WV, Wei SH, Davuluri RV, Plass C et al: Loss of estrogen receptor signaling triggers epigenetic silencing of downstream targets in breast cancer. Cancer research 2004, 64(22):8184-8192.
  33. Fan M, Nakshatri H, Nephew KP: Inhibiting proteasomal proteolysis sustains estrogen receptor-alpha activation. Molecular endocrinology 2004, 18(11):2603-2615.
  34. Jin VX, Leu YW, Liyanarachchi S, Sun H, Fan M, Nephew KP, Huang TH, Davuluri RV: Identifying estrogen receptor alpha target genes using integrated computational genomics and chromatin immunoprecipitation microarray. Nucleic acids research 2004, 32(22):6627-6635.
  35. Fan M, Bigsby RM, Nephew KP: The NEDD8 pathway is required for proteasome-mediated degradation of human estrogen receptor (ER)-alpha and essential for the antiproliferative activity of ICI 182,780 in ERalpha-positive breast cancer cells. Molecular endocrinology 2003, 17(3):356-365.
  36. Fan M, Long X, Bailey JA, Reed CA, Osborne E, Gize EA, Kirk EA, Bigsby RM, Nephew KP: The activating enzyme of NEDD8 inhibits steroid receptor function. Molecular endocrinology 2002, 16(2):315-330.
  37. Fan M, Goodwin ME, Birrer MJ, Chambers TC: The c-Jun NH(2)-terminal protein kinase/AP-1 pathway is required for efficient apoptosis induced by vinblastine. Cancer research 2001, 61(11):4450-4458.
  38. Fan M, Chambers TC: Role of mitogen-activated protein kinases in the response of tumor cells to chemotherapy. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2001, 4(4):253-267.
  39. Fan M, Goodwin M, Vu T, Brantley-Finley C, Gaarde WA, Chambers TC: Vinblastine-induced phosphorylation of Bcl-2 and Bcl-XL is mediated by JNK and occurs in parallel with inactivation of the Raf-1/MEK/ERK cascade. The Journal of biological chemistry 2000, 275(39):29980-29985.
  40. Fan M, Du L, Stone AA, Gilbert KM, Chambers TC: Modulation of mitogen-activated protein kinases and phosphorylation of Bcl-2 by vinblastine represent persistent forms of normal fluctuations at G2-M1. Cancer research 2000, 60(22):6403-6407.
  41. Fan M, Byrd C, Compadre CM, Compadre RL: Comparison of CoMFA models for Salmonella typhimurium TA98, TA100, TA98 + S9 and TA100 + S9 mutagenicity of nitroaromatics. SAR QSAR Environ Res 1998, 9(3-4):187-215.


clinical-laboratory-medicine-flyer Flyer