Marta E. Couce
Marta E Couce, MD, PhD
Professor of Pathology

University Hospitals Case Medical Center


1979- 1986 MD Universidad de Santiago de Compostela
1986-1991 PhD Estudios del Doctorado/Graduate School:
Universidad de Santiago de Compostela y East Carolina University (USA)
1991-1993 Research Associate Department of Anatomy and Cell Biology, East Carolina University, Greenville, NC 




Research Interest

  • Gastrointestinal Pathology
  • Breast Pathology
  • Neuropathology
  • Diagnostic Electron Microscopy
  • Fluorescent In Situ Hybridization
  • Muscle Pathology
  • Pathology Management
  • Bone and Soft Tissue Pathology
  • Molecular Anatomic Pathology

Professional Activities:

1999-2000 Research Associate Boston University Medical Center. Evans Biomedical Research Center Boston, MA
2000-2004 Assistant Professor of Pathology University of Pittsburgh Medical Center Pittsburgh,
2005 Consultant in Anatomic Pathology Hospital Son Llatzer
Palma de Mallorca  (IB, Spain
2005-2010 Consultant in Anatomic Pathology Hospital Universitario Son DuretaPalma de Mallorca (IB, Spain
2010- 2013 Chaipersonn Anatomic Pathology Hospital Universitario Son Dureta/Son Espases
Palma de Mallorca  (IB, Spain)
2013-Present Professor of Pathology and Ophthalmology University Hospitals Case Medical Center, Cleveland, OH



  1. Fraga Rodriguez M, COUCE ME, Rami Porta R , Ledo Andión R, Corbal Mosteiro M,  Berdugo Oviedo M, Perez Becerra y Calzadilla Martín. G. 1990. Carcinoides bronquiales: Estudio clínico, histopatológico e immunohistoquímico. Arch Bronconeumol. 26:12-16
  2. Burguera B, COUCE ME, Lage M, Viña MD, Dieguez C, Casanueva FF. 1991 Falta de efecto de la administración de TRH sobre la secreción de hormona de crecimiento, inducida por dexametasona. Rev. Clin Esp. 188:65.
  3. Antunez JR, COUCE ME, Fraga M, Garcia-Caballero T, Beiras A, Perez-Becerra E, Forteza J. 1991.  Immunohistochemical demonstration of neuronal and astrocytic markers and oncofaetal antigens in retinoblastomas. Histol Histopathol 6: 241-6. 
  4. McGinty JF, COUCE ME, Bohler WT and Ways K. 1991. Protein kinase C subspecies distinguish major cell types in rat hippocampus: an immunocytochemical and in situ hybridization histochemical study. Hippocampus. 1:293-302
  5. COUCE ME, Weatherington AJ, McGinty JF. 1992  Expression of IGF-II/Man 6-P R in the rat hippocampus. An in situ hybridization and immunocytochemical study.  Endocrinology 131: 1636-1642
  6. Levy A, COUCE ME, Lightman SL, and Young WS III. 1992. The effects of pituitary stalk transection, hypophysectomy ad thyroid hormone status on insulin-like growth factor 2, growth hormone releasing hormone and somatostatine mRNA prevalence in rat brain. Brain Research 579: 1-7.
  7. Fraga M, Garcia-Caballero T, Antunez JR, COUCE ME, Beiras A, Forteza J. 1993. A comparative immunohistochemical study of phaechromocytomas and paragangliomas. Histol Histopathol 8:429-36
  8. COUCE ME, Smith AW, Ways D., and McGinty JF. 1995. Streptozotocin-induced diabetes alters protein kinase C isoforms in rat hippocampal neurons.  Endocrinology and Metabolism 2:135-146
  9. Rother KI, Carney JA, COUCE ME, Charlesworth J, and Butler P. 1995 Islet amyloid polypeptide in pancreatic tissue of children with persistent hyperinsulinemic hyperglycemia due to primary islet hyperplasia and nesidioblastosis. J Clin Endocrinol Metab 80:1956-1959
  10. COUCE ME, Kane LA, O’Brien TD, Soeller W, Kreutter D and Butler P 1996 Induction of insulin resistance in mice transgenic for human islet amyloid polypeptide, causes islet amyloidosis and b-cell dysfunction. Diabetes 45:1094-1101
  11. COUCE ME, O’Brien TD, Moran A and Butler P 1996  Diabetes Mellitus in cystic fibrosis is characterized by islet amyloidosis J. Clin Endocrinol Metab 81:1267-1272
  12. COUCE ME, Burguera B, Parisi JE, Jensen MD, Lloyd RV. 1997. Localization of leptin receptor in the human brain. Neuroendocrinology 66: 145-150
  13. Caselli R.J., COUCE ME, Osborne D., Deen H.G., Parisi J.E. 1998. From slowly progressive amnesic syndrome to rapidly progressive Alzheimer disease. Alzheimer Dis Assoc Disord 12:251-3
  14. COUCE ME, Bautista D, Costa J, Carter D. 1999. Analysis of K-ras, N-ras, H-ras and p53 in lung neuroendocrine neoplasms. Diagn Mol Pathol 8: 71-79.
  15. Jin L, Burguera B, COUCE ME, Lamsam J, K. Kovacs, Lloyd RV. 1999 Leptin receptor (OB-Rb) expression in normal and neoplastic human pituitaries. Regulation of pituitary cell proliferation by leptin. J Clin Endo Metab84:2903-2911.
  16. COUCE ME, Perry A, Webb P, Scheithauer BW. 1999. Fibrous meningioma with tyrosine-rich crystals. Ultrastructural Pathology 23:341-345.
  17. Burguera B, COUCE ME, Long J, Lamsam J, Parisi JE, Lloyd RV. 2000. The long form of the leptin receptor (OB-Rb) is widely expressed in the human brain.. Neuroendocrinology 71: 187-195.
  18. Jin L, Burguera B, COUCE ME, K. Kovacs, Lloyd RV .2000. Leptin receptor (OB-Rb) expression in rat pituitaries. Endocrinology 141: 333-339
  19. Burguera B, COUCE ME, Curran G., Lamsam J, Cleary M, Poduslo J. 2000. Obesity is associated with a decreased of leptin permeability across the blood brain barrier and up regulation of leptin receptor in the hypothalamus. Diabetes 49: 1219-1223
  20. COUCE ME, Aker FV, Scheithauer BW. 2000. Chordoid meningioma: A clinico-pathologic study of 42 cases. Am. J Surg. Pathol. 24 (7): 899-905
  21. Burguera B, COUCE ME, Lloyd RV. 2000. Leptin receptor and the brain: a tale of body weight regulation. Curr. Op in Endocrinol. Metab: 7:225-230
  22. Burguera B, COUCE ME. Leptin Access into the brain: A saturated transport system versus a post-receptor defect in obesity. 2000. J. Clin Invest. E-Letter.
  23. Lee CH, Carter D, Philpotts LE, COUCE ME, Horvath LJ, Lange RC, Tocino I. Ductal carcinoma in situ diagnosed with stereotactic core needle biopsy: can invasion be predicted? Radiology 2000; 217(2):466-70
  24. Burguera B, COUCE ME.  Leptin Access into the Brain: a Saturated Transport Mechanism in Obesity. 2001. Physiol Behav. 2001; 74(4-5):717-20.
  25. COUCE ME, Green D, Brunetto A, Achim C, Lloyd RV, Burguera B.  Limited brain access for leptin in obesity. 2001. Pituitary. 2001 Jan-Apr;4(1-2):101-10.
  26. Lloyd RV, Jin L, Tsumanuma I, Vidal S, Kovacs K, Horvath E, Scheithauer BW, COUCE ME, Burguera B. Leptin and leptin receptor in anterior pituitary function. Pituitary 2001 Jan-Apr; 4(1-2):33-47
  27. Kondziolka D, COUCE ME, Niranjan A, Maesawa S, Fellows W. Histology of the 100-Gy Thalamotomy in the baboon. 2002. Radiosurgery: 4: 279-284
  28. Ozolek JA, Finkelstein, SD, COUCE ME. Gliosarcoma with epithelial differentiation: Molecular correlates. A case report and review of the literature. 2004. Mod Pathol. 2004 Jun;17(6):739-45.
  29. Burguera B, COUCE ME. Type 2 Diabetes and obesity. A clinical problem of epidemic proportions. Medicina Clinica. 2004; 5:3-6
  30. Mohan D, Finkelstein SD, Swalsky PA, Sasatomi E, Wiley C, Hamilton RL, Lieberman F, COUCE ME. Microdissection genotyping of gliomas: therapeutic and prognostic considerations. Mod Pathol. 2004 Nov;17(11):1346-58.
  31. Boada FE, Tanase C, Davis D, Walter K, Torres-Trejo A, Couce M, Hamilton R, Kondziolka d, Bartynski W, Lieberman F. Non-invasive assessment of tumor proliferation using triple quantum filtered 23/Na MRI: Technical challenges and solutions. Conf Proc. IEEE Med Biol Soc. 2004;  7:5238-41.
  32. Ionescu DN,  McFadden K,  Unni  KK, COUCE ME. 2005: Pathologic Quiz Case: A 33-Year-Old Woman With a Large Temporal Mass. Archives of Pathology and Laboratory Medicine:. 129, (4) : 539–540.
  33. COUCE ME,Burguera B. Obesidad y Diabetes Mellitus Tipo 2: Un autentico Problema Macrosanitario. Medicina Clinica. 2004; 5 :3-6.
  34. COUCE ME, Cottam DR, Teijeiro R, Esplen J, Schauer P, Burguera B. The role of central Ghrelin in human obesity. J Endocrinol Invest 29 (7): 599-605. 2006.
  35. COUCE ME, Cottam DR, Teijeiro R, Esplen J, Schauer P, Burguera B.Is ghrelin the culprit for weight loss after gastric bypass surgery? A negative answer. Obes Surg. 2006 Jul;16(7):870-8..
  36. BurgueraB, BrunettoA, Garcia-OcanaA, TeijeiroR, EsplenJ, ThomasT, COUCE ME, ZhaoA. Leptin increases proliferation of human osteosarcoma cells through activation of PI(3)-K and MAPK pathways. Med Sci Monit. 2006 Oct 27;12(11):BR341-349
  37. COUCE ME, Esplen J., Teijeiro R, Achim C., Burguera B. Ghrelin has trophic effects on human neuroglial cells. An in vitro study.  Obesity and Metabolism 2 (2): 87-94. 2006
  38. Gene AH. Gardner PA. COUCE ME. Rapidly expanding brain mass.Transplant Infectious Disease. 9(3):211-3, 2007.
  39. COUCE ME. Medina-Flores R. Wong M. Chu CT. Occult germ cell tumour presenting as spontaneous intracerebral haemorrhage.Histopathology. 50(6):789-93, 2007.
  40. Burguera B, Agusti A, Arner P, Baltasar A, Barbe F, Barcelo A, Breton I, Cabanes T, Casanueva FF, COUCE ME, Dieguez C, Fiol M, Fernandez Real JM, Formiguera X, Fruhbeck G, Garcia Romero M, Garcia Sanz M, Ghigo E, Gomis R, Higa K, Ibarra O, Lacy A, Larrad A, Masmiquel L, Moizé V, Moreno B, Moreiro J, Ricart W, Riesco M, Salinas R, Salvador J, Pi-Sunyer FX, Scopinaro N, Sjostrom L, Pagan A, Pereg V, Sánchez Pernaute A, Torres A, Urgeles JR, Vidal-Puig A, Vidal J, Vila M. Critical assessment of the current guidelines for the management and treatment of morbidly obese patients. J Endocrinol Invest. 2007 30:844-52.
  41. F.F. Casanueva, COUCE ME, C. Dieguez, M. Fiol, J.M. Fernandez Real, X. Formiguera, G. Fruhbeck, M. Garcia Romero, M. Garcia Sanz, E. Ghigo. Critical assessment of the current guidelines for the management and treatment of morbidly obese patients. J. Endocrinol. Invest. 30: 844-852, 2007.
  42. Differences in mitochondrial function and antioxidant  systems between regions of human glioma.  Santandreu  Santandreu F., Brell Doval M., Gene Heym Al., Guevara R., Oliver J., COUCE ME,, Roca P.  Cell Physiol Biochem;22:757-768, 2008.
  43. Diferencias en la expresión de PEX entre el centro y la periferia tumoral gliomas. Relación con el subtipo histológico y el grado tumoral. Marta Brell1, J. Ibáñez 1, Ana Felpete , Bartolome Burguera , Marga Frontera, COUCE MEMedicina Balear 2010; 25 (3); 12-21
  44. Quantitative analysis of matrix metalloproteinase-2 mRNA expression in central and peripheral regions of gliomas.  Marta Brell, J. Ibáñez , Ana Felpete , Bartolome Burguera , Marga Frontera,  COUCE  ME. Brain tumor Pathol ; 28:137-144. 2011
  45. Tur J, Alòs M, Iglesias L, Luque L, Colom A, Escudero A, Martínez D, Pagán A, Ugarriza E, Frontera M, Nicola G, Palomero A, Tofé S, Urgeles JR, Barceló A, COUCE M, De La Peña M, Fiol M, Cortés B, Terés E, Tumbarello A, Álvarez C, Salinas R, Pereg V, González X, Burguera B . TRAMOMTANA (Tratamiento Multidisciplinar de la Obesidad Mórbida: Medicamentos, Terapia de comportamiento, Apoyo Nutricional y Actividad física). De la pregunta a la realidad de un ensayo clínico investigador iniciado (II). Endocrinol Nutr. 2011; 58:299-307
  46. Burguera B; Colom A; Piñero E; Yanez A; Caimari M, Juan Tur J,  Frontera M, COUCE M,  Cardó E,  Aguiló A, Burguera  A,  Cabeza E. ACTYBOSS: Activity, Behavioral Therapy in Young Subjects. After-school intervention Pilot Project on obesity prevention. Incentive-driven children obesity prevention program. Obes Facts. 2011;4 :400-6.
  47. Sampol López, M. Brell Doval, R. Guevara de Bonis, J. Ibáñez Domínguez,COUCE MEValor de la expresión del ARN mensajero de la isocitrato deshidrogenasa (IDH1) como predictor de agresividad en gliomas. Medicina Balear; 27 (1); 10-18,  2012.
  48. Gene AH, COUCE ME, Brell M,  Picado MJ. Multiple myeloma presenting as an asymptomatic forehead mass resembling solitary plasmacytoma. Wien Klin Wochenschr 123: 3. 2011
  49. Ramos-Murguialday M, Lasa-Mene´ndez, V, Iriarte-Ortabe JI, COUCE MEChondrosarcoma of the Mandible Involving Angle, Ramus, and Condyle. The Journal of Craniofacial Surgery 23 (4): 1216-1218. 2012.
  50. Forteza A., Ballester Ruiz C., Visvesvara G., Muncunill Ribas J., Besalduch Vidal J., COUCE ME. Resolution of refractory thrombotic thrombocytopenic púrpura (TTP) after succesful treatment of a fulminant colitis due to Entamoeba histolytica. Gastroenterol. Hepatol 36: 294-5. 2013.
  51. Ryan L. Lym, Quinn T. Ostrom, Carol Kruchko, COUCE ME, Daniel J. Brat, David N. Louis, Jill S. Barnholtz-Sloan. Completeness and concordancy of WHO grade assignmentfor brain and central nervous system tumors in the United States,2004–2011. Journal of Neuro-Oncology. 123(1):43-51, 2015.
  52. See comment in PubMed Commons belowLacuey N, Davila JC, Zonjy B, Amina S, COUCE ME, Turnbull J, Miller J, Lüders H, Lhatoo SD. Lesion-negative anterior cingulate epilepsy. Epileptic Disord. 2015 Jun 9.
  53. Abboud SE; Wolansky LJ; Manjila SV; Lo SS; Arafah BM; Selman WR; COUCE ME; Rogers LR. Histologically Proven Radiation-Induced Brainstem Glioma 93 Months After External Beam Radiotherapy for Pituitary Macroadenoma: Radiation Treatment Dose and Volume Correlation. Journal of Neuroimaging. 25(4):674-6, 2015


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