kalra, jawahar (jay)
Kalra Jawahar Jay, MSc, MD, PhD, FRCPC, FCAHS
Professor and Director

Department of Pathology and Laboratory Medicine
University of Saskatchewan
Canada

Education

1981 M.D Medicine Memorial University of Newfoundland, Canada
1979 B.Med.Sci Medicine Memorial University of Newfoundland, Canada
1976 Ph.D Biochemistry Memorial University of Newfoundland, Canada
1972 M.Sc Biochemistry Memorial University of Newfoundland, Canada
1969 M.Sc Biochemistry Aligarh University, India
1967 B.Sc Chemistry/Biology Aligarh University, India

 

Biography

Dr. Jay Kalra is a Professor of Pathology in the University of Saskatchewan and has served as Head of the Department of Pathology and Laboratory Medicine, Saskatoon Health Region. He is recognized for his many contributions as a clinical scientist, academic leader and health system administrator. He has been a pioneer in establishing guidelines for thyroid-function testing, laboratory utilization, and has also contributed nationally and internationally in the area of total quality management and lean transformation strategies. He has published extensively and is the author of the book “Medical Errors and Patient Safety: Strategies to reduce and disclose medical errors and improve patience safety.”

Research Interest

  • Ischemia reperfusion Injury – role of oxygen free radicals and antioxidants in various clinical diseases including heart failure and atherosclerosis
  • Quality Care and Patient Safety
  • Laboratory Utilization in Healthcare
  • Medical Error & Disclosure of Adverse Events
  • Total Quality Management in Laboratory Medicine

 

Professional Activities:

2014-15 Assistant Dean (Interim), Governance & Faculty Affairs, College of Medicine
2011 Acting Head, Department of Pathology
2009 Acting Head,   Department of Pathology & Laboratory Medicine
1998 -2000 Head, Department of Pathology
1995 -1998 Head, Department of Pathology
1991-1995 Head, Department of Pathology
1991-present Professor, Department of Pathology
1990- 1991 Appointed Acting Head, Department of Pathology
1989 Associate Professor, Department of Pathology
1988 -1991 Associate Professor, Department of Pathology
1986 ‑1989 Assistant Professor, Department of Pathology
1985 Assistant Professor, Department of Pathology
APPOINTMENTS (Clinical)
1994-2000 Head (Clinical Chief), Department of Laboratory Medicine, Saskatoon District Health
1994-2000 Member, Medical Advisory Committee, Saskatoon District Health
1997-2000 Member, Credentials Committee, Saskatoon District Health
1994-1996 Member, Executive-Medical Advisory Committee, Saskatoon District Health
1996 Acting Chief of Staff, Saskatoon District Health
1996-97 Founding Chair, SDH Infection Control Committee, Saskatoon District Health
1997 Mock Surveyor, Surgical Care Group, Saskatoon District Health
1994-95 Member, Medical Equipment Committee, Saskatoon District Health
1994-96 Member, Ad Hoc Committee of Medical Advisory Committee, Saskatoon District Health, Remuneration for Clinical Chief's
1992-94 Member, Clinical Review Panel, Saskatoon District Health Board, Saskatoon
1994-present Active Medical Staff, Saskatoon District Health

 

Publications

  1. Baniak, N., Campos-Baniak, G., Mulla, A., Kalra, J. 2015. Vitreous Humour: A Short Review on Post-mortem Applications. J Clin Exp Pathol. 5(1): 1-7
  2. Entwistle M, Kalra J. 2014. Barriers to Medical Error Disclosure: An Organizing Framework and Themes for Future Research. Austin J Pathol Lab Med. 1 (2): 1-6.
  3. Kalra J, Entwistle M. 2014. Medical Error Disclosure and Professionalism: The Right Thing to Do. Annals of Clinical Pathology. 2(2): 1022-1023.
  4. Kalra J, Kalra N, Baniak N. 2013. Medical Error, Disclosure and Patient   Safety: A Global View of Quality Care (Review Article). Clinical Biochemistry. 46: 1161-69.
  5. Chadha R, Singh A, Kalra J. 2012. "Lean and queuing integration for the transformation of health care processes: A lean healthcare model", Clinical Governance: an International Journal. 17: 191-99
  6. Kalra J, Entwistle L, Suryavanshi S, Chadha R. 2010. Quality Assessment using concordance and discordance rates in medical findings. Clinical Governance: An International Journal 15(2): 128-133
  7. Chadha R, Kalra J. 2010. Lean Six Sigma: Window of Opportunity. Quality Progress. March 2010, 32-39.
  8. Mohamed A, Waris HM, Ramadan H, Qureshi M, Kalra J. 2009. Amelioration of chronic relapsing experimental autoimmune encephalomyelitis using thymoquinone. J Biomed Sci Instrum 45: 274-279.
  9. Meng, Q., Zhu, S., Booth, C., Stevens, L., Bertsch, B., Qureshi, M., Kalra, J. 2006. Impact of the Cardiac Troponin Testing Algorithm on Excessive and InappropriateTroponin Test Requests. Am J Clin Pathol 126: 195-199
  10. Kalra J, Massey K, Mulla A.  2005.  Disclosure of Medical Error:  Policies and Practice (practice article) Journal of the Royal Society of Medicine 98 (7): 307-309.
  11. Kalra J. 2005. Disclosure of Medical Error Peter Gooderham, Cardif Lay School, Museum Avenue Cardiff, UK Authors Reply, Journal of the Royal Society of Medicine 98 (9): 437
  12. Kalra J. Massey, K., Mulla, A. 2005. Medical Error Disclosure:  A catch -22 (Features article) Royal College Outlook 2: 5-7.
  13. Mulla A, Massey KL, Kalra J. 2005. Vitreous Humor Biochemical Constituents- Evaluation of Between-Eye Differences. American Journal of Forensic Medicine and Pathology. 26:146-149
  14. Kalra J. 2004. Medical errors:  an introduction to concepts. Clinical Biochemistry 37:1043-1051
  15. Kalra J. 2004.  Medical errors: impact on clinical laboratories and other critical areas. Clinical Biochemistry 37: 1052-1062
  16. Kalra J. 2004. Medical errors: overcoming the challenges. Clinical Biochemistry 37:1063-1071
  17. Kalra J, Massey KL, Mulla A. 2004. Disclosure of errors. Health Affairs (Millwood) 23(6): 273-274
  18. Kalra J. 2004. E-letter to CMAJ Nov 15 Mandatory Error Reporting in Saskatchewan. Can Med Assoc J, 171:1158, http:/www.cmaj.ca/cgi/eletters/171/10/1158-a
  19. Shuaib A, Yang Y, Siddiqui MM, Kalra J. 1998.  Intra-arterial Urokinase Produces Significant Attenuation of Infarction Volume in an Embolic Focal Ischemia Model.  Experimental Neurology. 154: 330-335
  20. Kakkar R, Mantha SV, Radhi J, Prasad K, Kalra J. 1998.  Increased oxidative stress in rat liver and pancreas during progression of streptozotocin-induced diabetes.  Clinical Science. 94: 623-632
  21. Prasad K, Mantha SV, Kalra J, Lee P. 1997 Prevention of hypercholesterolemic atherosclerosis by garlic, an antioxidant.  J. Cardiovasc. Pharmacol. Therapeutics, 2:309-319
  22. Kapoor R, Kalra J, Prasad K. 1997. Cardiac depression and cellular injury in hemorrhagic shock and re-infusion:  Role of free radicals.  Mol. Cell. Biochem, 176:291-301
  23. Kakkar R, Mantha SV, Radhi J, Prasad K, Kalra J. 1997. Antioxidant Defense System in Diabetic Kidney: A Time Course Study.  Life Sciences 60:667-679
  24. Prasad K, Mantha SV, Kalra J, Lee P. 1997 Hypercholesterolemia-induced oxidative stress in heart and its prevention by Vitamin E.  Int J Angiol 6:13-17
  25. Kakkar R, Mantha SV, Kalra J, Prasad K. 1996.  Time course study of oxidative stress in aorta and heart of diabetic rat.  Clinical Science. 91:441-448
  26. Prasad K, Mantha SV, Kalra J, Kapoor R, Baylon RCK. 1997.  Purpurogallin in the prevention of hypercholesterolemic atherosclerosis. Int J Angiol 6: 157-166
  27. Prasad K, Chan WP, Kalra J, Bharadwaj B. 1996.  Prevention of Post-Pump Myocardial Dysfunction by Glutathione.  Ann. N.Y. Acad. Sci 793:400-413
  28. Mantha SV, Kalra J, Prasad K. 1996.  Effects of Probucol on hypercholesterolemia - induced changes in antioxidant enzymes.  Life Sci. 58: 503-509
  29. Kanthan R, Shuaib A, Griebel R, Miyashita H, Kalra J.  1996.  Glucose-induced decrease in glutamate levels in ischemic human brain by in-vitro microdialysis.  Neuroscience Letters 209: 207-209
  30. Kanthan R, Shuaib A, Griebel R, El-Alazounni H, Miyashita H, Kalra J. 1996.  Evaluation of Monoaminergic Neurotransmitters in the acute focal ischemic Human brain Model by intracerebral in vivo microdialysis.  Neurochemical Research 21: 563-566
  31. Solez K, Jewell LD, Kalra J, Moore S, Silver M.  1996.  Coming Full Circle:  Trainee numbers and attrition in pathology and laboratory medicine training programs in Canada 1987-1995:  A caper resident tracking study undertaken by the Association of Chairmen of Pathology in Canadian Medical Schools.  Annals of the Royal College of Physicians and Surgeons of Canada. 29: 23-28
  32. Prasad K, Debnath D, Kalra J, Prasad M.  1996.  Protective effect of methionine in the ischemia-reperfusion cardiac injury in canine model.  Int J Angiol 5: 93-101
  33. Prasad K, Gupta JB, Kalra J, Lee P, Mantha SV, Bharadwaj, B. 1996.  Oxidative stress as a mechanism of cardiac failure in chronic volume overload in canine model.  J Mol Cell Cardiol 28: 375-385
  34. Shoker A, Sheridan D, Kalra J.  1995.  Differential effect of alloantigen blocking antibodies on unprinted and memory T-helper cells.  Transplantation.  60: 184-191
  35. Kanthan R, Goplen G, Griebel T, Miyashita H, Burbridge B, Kalra J,  Shuaib A. 1995.  Clinical evaluation of vasospasm in subarachnoid haemorrhage by in vivo microdialysis:  J Neurology, Neurosurgery, and Psychiatry 59: 646-7
  36. Mainprize T, Shuaib A, Ijaz S, Kanthan R, Miyashita H, Kalra J.  1995.  GABA concentrations in the striatum following repetitive cerebral ischemia.  Neurochemical Research 20: 957-961
  37. Kakkar R, Kalra J, Mantha SV, Prasad K. 1995. Lipid peroxidation and activity of antioxidant enzymes in diabetic rats.  Mol Cell Biochem 151: 113-119
  38. Shuaib A, Truelove D, Ijaz S, Kanthan R, Kalra J.  1995.  The effect of post-ischemic hypothermia following repetitive cerebral ischemia in gerbils.  Neurosci Letts 186: 165-168
  39. Kalra J, Mantha SV, Kumar P, Prasad K. 1994.  Protective effects of lazaroids against oxygen free radicals-induced lysosomal damage.  Mol Cell Biochem 136: 125-129
  40. Moyana T, Xiang J, Qi Y, Kalra J.  1994.  Development of the early mucosal lesions in experimental inflammatory bowel disease - implications for pathogenesis.  Exptl Mol Pathol 60: 119-129
  41. Prasad K, Gupta JB, Kalra J.  1994.  Effects of Platelet-activating factor on Cardiovascular function, oxygen free radical status and blood chemistry.  Int J Angiol 3: 1-11
  42. Gupta JB, Prasad M, Kalra J, Prasad K.  1994.  Platelet-activating-factor-induced changes in cardiovascular function and oxyradical-status of myocardium in presence of PAF-antagonist, CV-6209.  Angiology 45:25-36
  43. Truelove D, Shuaib A, Ijaz S, Ishaqzay R, Kalra J. 1994.  Neuronal protection with superoxide dismutase in repetitive forebrain ischemia in gerbils.  Free Rad Biol Med 17:445-450
  44. Kalra J, Prasad K.  1994.  Oxygen free radicals and cardiac depression.  Clin Biochem 27:163-168
  45. Raju RVS, Kalra J, Sharma RK.  1994.  Purification and properties of bovine spleen N-myristoyl CoA proteins: N-myristoyl transferase.  J Biol Chem 269:12080-12083
  46. Sharma RK, Kalra J.  1994.  Characterization of calmodulin-dependent cyclic nucleotide phosphodiesterase isozymes.  Biochem J 299:97-100
  47. Kalra J, Mantha SV, Prasad K.  1994.  Oxygen-Free Radicals: Key Factors in Clinical Diseases.  Lab Medica International  11:16-21
  48. Prasad K, Debnath D, Kalra J, Lee P.  1994.  Effects of Dimethylthiourea on the cardiac function and oxyradical status in ischemia/reperfusion injury.  Ann N Y Acad Sci 723:375-379
  49. Sharma RK, Kalra J.  1994.  Molecular interaction between cAMP and calcium in calmodulin-dependent cyclic nucleotide phosphodiesterase system.  Clinical and Investigative Medicine 17:389-397
  50. Prasad K, Kalra J, Lee P.  1994.  Role of oxygen free radicals in hypercholesterolemic atherosclerosis: Effects of Probucol.  Int J of Angiology 3:100-112
  51. Truelove D, Shuaib A, Ijaz S, Richardson S, Kalra J.  1994.  Superoxide dismutase, catalase and U78517F attenuate neuronal damage in gerbils with repeated brief ischemic insults.  Neurochemical Research 19:665-671
  52. Shuaib A, Ijaz S, Mazagri R, Kalra J, Sulakhe-Hemmings S, Senthilselvan A, Crosby N.  1994.  Hypothyroidism protects the brain during transient forebrain ischemia in gerbils.  Experimental Neurology 127:119-125
  53. Prasad K, Gupta JB, Kalra J.  1994.  Effects of platelet-activating factor on Cardiovascular function, oxygen free radical status and blood chemistry.  Int J of Angiol 3:1-11
  54. Gupta JB, Prasad M, Kalra J, Prasad K.  1994.  Platelet-activating-factor-induced changes in Cardiovascular Function and oxyradical-status of myocardium in presence of PAF-antagonist, CV-6209.  Angiology 45:25-36
  55. Mantha SV, Prasad M, Kalra J, Prasad K. 1993.  Antioxidant Enzymes in hypercholesterolemia and Effects of Vitamin E in rabbits.  Atherosclerosis 101:135-144
  56. Pahwa R, Kalra J.  1993.  A critical review of the neurotoxicity of styrene in humans.  Vet Human Toxicol 35:516-520
  57. Prasad K, Kalra J. 1993.  Oxygen free radicals and hypercholesterolemic atherosclerosis: Effect of Vitamin E.  Am Heart J 125: 958-973
  58. Sharma RK, Kalra J. 1993.  Ginsenosides are potent and selective inhibitors of some calmodulin-dependent phosphodiesterase isozymes.  Biochemistry 32: 4975-4978
  59. Prasad K, Kalra J, Bharadwaj L. 1993.  Cardiac depressant effects of oxygen free radicals.  Angiology 44: 257-270
  60. Barnes JA, King MJ, Kalra J, Sharma RK. 1992.  Novel bovine heart calmodulin-dependent protein kinase which phosphorylates a HMW calmodulin-binding protein.  Biochem Biophys Res Commun 186: 819-826
  61. Xiang J, Moyana T, Kalra J, Hamilton T, Yimin Q. 1992.  Construction and characterization of a high-affinity chimeric anti-colorectal carcinoma antibody ccM4.  Mol Biotherapy 4: 1-10
  62. Shuaib A, Kalra J, Prasad M, Mantha S, Wallace K. 1992.  Lipid profile in acute stroke.  J Stroke and Cerebrovasc Dis 2: 125-130
  63. Shuaib A, Ijaz S, Hasan S, Kalra J. 1992.  Gamma-vinyl GABA prevents hippocampal and substantia nigra reticulata damage in repetitive transient forebrain ischemia.  Brain Res 590: 13-17
  64. Shuaib A, Ijaz S, Kalra J, Code W. 1992.  During repetitive forebrain ischemia post-ischemic hypothermia protects neurons from damage.  Canadian J Neurol Sci 19: 428-432
  65. Kalra J, Rajput AH, Subrahmanyam VM, Chaudhary AK, Prasad K. 1992.  Oxygen free radical producing activity of polymorphonuclear leukocytes in patients with Parkinson's disease.  Mol Cell Biochem 112: 181-186
  66. Kalra J, Rajput AH, Subrahmanyam VM, Prasad K. 1992.  Serum antioxidant enzyme activity in Parkinson's disease.  Mol Cell Biochem 110: 165-168
  67. Prasad K, Kalra J, Debnath D. 1992.  Cardiovascular effects of activated polymorphonuclear leukocytes.  In: Symposium on Molecular Basis of Oxidative Damage by Leukocytes.  Jesaitis, A.J. and Dratz, E.A. (Eds.) CRC Press, London: pp. 329-332
  68. Shuaib A, Ijaz S, Kalra J, Code W. 1992.  Repetitive transient forebrain ischemia in gerbils: Delayed neuronal damage in the substantia nigra reticulata.  Brain Res 574: 120-124
  69. Prasad K, Lee P, Mantha SV, Kalra J, Prasad M, Gupta JB. 1992.  Detection of ischemia-reperfusion cardiac injury by cardiac-muscle chemiluminescence.  Mol Cell Biochem 115: 49-58
  70. Prasad K, Kapoor R, Kalra J. 1992.  Methionine in protection of hemorrhagic shock: Role of oxygen free radicals and hypochlorous acid.  Circulatory Shock 36: 265‑276
  71. Prasad K, Gupta JB, Kalra J, Bharadwaj B. 1992.  Oxygen free radicals in volume overload heart failure.  Mol Cell Biochem 111: 55-59
  72. Prasad K, Kalra J, Bharadwaj B, Chaudhary AK. 1992.  Increased oxygen free radical activity in patients on cardiopulmonary bypass undergoing aortocoronary bypass surgery. Am Heart J 123: 37‑45
  73. Kapoor R, Kalra J, Prasad K. 1992.  Beneficial effects of methionine on myocardial hemodynamic and cellular functions in hemorrhagic shock.  Angiology 43: 294-305
  74. Kalra J, Chaudhary AK, Prasad K. 1991.  Increased production of oxygen free radicals in cigarette smokers.  Int J Exp Pathol 72: 1‑7      
  75. Prasad K, Lee P, Kalra J. 1991.  Influence of endothelin on cardiovascular function, oxygen free radicals and blood chemistry.  Am Heart J 121: 178‑187
  76. Prasad, K., Chaudhary, A.K., Kalra, J. 1991.  Oxygen-derived free radicals producing activity and survival of activated polymorphonuclear leukocytes.  Mol Cell Biochem 103: 51-62
  77. Dyck RF, Asthana S, Kalra J, West ML, Massey KL. 1990.  A modification of the urine osmolal gap:  An improved method for estimating urine ammonium.  Am J Nephrol 10: 359-362
  78. Kalra J, Chaudhary AK, Massey KL, Prasad K. 1990.  Effect of oxygen free radicals, hypoxia and Ph on the release of liver lysosomal enzymes.  Mol Cell Biochem 94: 1-8
  79. Prasad K, Kalra J, Chaudhary AK, Debnath D. 1990.  Effect of polymorphonuclear leukocyte‑derived oxygen free radicals and hypochlorous acid on cardiac function and some biochemical parameters.  Am Heart J 119: 538‑550
  80. Prasad K, Kalra J, Bharadwaj B. 1989.  Increased chemiluminescence of polymorphonuclear leukocytes in dogs with volume overload heart failure.  Br J Exp Path 70: 463‑468
  81. Kalra J, Chaudhary AK, Prasad K. 1989.  Role of oxygen free radicals and Ph on the release of cardiac lysosomal enzymes.  J Mol Cell Cardiol 21: 1125‑1136
  82. Kalra J. et al. 1989.  Oxygen free radicals may increase risk of smoking‑related diseases.  American Family Physician, Medigrams 39: 218
  83. Prasad K, Kalra J. 1989.  Experimental atherosclerosis and oxygen free radicals.  Angiology 40: 835‑843
  84. Prasad K, Kalra J, Massey KL, Bharadwaj B. 1989.  Increased production of oxygen free radicals by polymorphonuclear leukocytes in heart failure due to aortic stenosis.  Angiology 40: 472‑478
  85. Prasad K, Kalra J, Chan WP, Chaudhary AK. 1989.  Effect of oxygen free radicals on cardiovascular function at organ and cellular level.  Am Heart J 117: 1196‑1202
  86. Prasad K, Kalra J, Buchko G. 1988.  Acute hemorrhage and oxygen free radicals.  Angiology 39: 1005‑1013
  87. Kalra J, Lautner D, Massey KL, Prasad K. 1988.  Oxygen free radicals induced release of lysosomal enzymes in vitro.  Mol Cell Biochem 84: 233‑238
  88. Prasad K, Kalra J. 1988.  Oxygen free radicals and heart failure.  Angiology 39: 417‑420
  89. Kalra J, Balion C, Massey KL, Laxdal VA. 1988.  Regulation of carnosine metabolism: The subcellular localization of carnosinase in liver.  Clin Biochem 21: 315‑318
  90. Kalra J, Laxdal VA, Walker S, Massey KL. 1987.  Evaluation and assessment of high sensitivity thyrotropin methods as an index for thyroid function.  Clin Biochem 20: 307‑312
  91. Kalra J, Hart IR. 1987.  Value of free thyroxine (FT4), free triiodothyronine (FT3), and sensitive thyrotropin (TSH) assay in the assessment of optimal thyroxine therapy.  Clin Biochem 20: 265‑267
  92. O'Leary TJ, Ooi TC, Miller JD, Branchaud CL, Kalra J. 1986.  Virilization of two siblings by maternal androgen‑secreting adrenal adenoma.  J Pediatr 109: 840‑842
  93. Gault MH, Kalra J, Longerich L, Dawe M. 1982.  Digoxigenin Biotransformation.  Clin Pharmacol Ther 31: 695‑704
  94. Gault H, Kalra J, Ahmed M, Kepkay D, Longerich L, Barrowman J. 1981.  Influence of gastric Ph on digoxin biotransformation.  II. Extractable urinary metabolites.  Clin Pharmacol Ther 29: 181‑190
  95. Gault MH, Churchill DN, Kalra J. 1980.  Loading dose of digoxin in renal failure.  Br J Clin Pharmacol 9: 593‑597
  96. Gault H, Kalra J, Ahmed M, Kepkay D, Barrowman J. 1980.  Influence of gastric Ph on digoxin biotransformation. I. Intragastric hydrolysis.  Clin Pharmacol Ther 27: 16-21
  97. Gault MH, Ahmed M, Kalra J, Senciall I, Cohen W, Churchill D. 1980.  Comparison of infrared and wet chemical analysis of urinary tract calculi.  Clin Chim Acta 104: 349‑359
  98. Kalra J, Mamer OA, Gregory B, Gault MH. 1977.  Interference by endogenous p‑hydroxyphenylacetic acid with estimation of N‑acetyl p‑aminophenol in urine by gas chromatography.  J Pharm Pharmacol 29: 127‑128
  99. Kalra J, Brosnan JT. 1974.  The subcellular localization of glutaminase isoenzymes in rat kidney cortex.  J Biol Chem 249: 3255‑60

 

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