Jianhua Luo
Jianhua Luo, MD, PhD
Professor and Director

Department of Pathology
University of Pittsburgh School of Medicine


1978- 1982 M.D Medicine Guangzhou Medical Institute, Canton, China
1985- 1991 Ph.D Pharmacology University of Maryland at Baltimore



Dr. Luo been studying molecular pathology related to human malignancies in the last 23 years. Currently, he is a Professor of Pathology and Director of High Throughput Genome Center at University of Pittsburgh. In the last 13 years, Dr. Luo has been largely focusing on genetic and molecular mechanism of human prostate and hepatocellular carcinomas. In this period, his group has identified and characterized several genes that are related to prostate cancer and hepatocellular carcinoma, including SAPC, myopodin, CSR1, GPx3, ITGA7, MCM7, MT1h and GPC3. He has characterized several signaling pathways that play critical role in prostate cancer development, including Myopodin-ILK-MCM7 inhibitory signaling, myopodin-zyxin motility inhibition pathway, CSR1-CPSF3 and CSR1-XIAP apoptotic pathways, MT1h-EHMT1 egigenomic signaling, ITGA7-HtrA2 tumor suppression pathway, GPx3-PIG3 cell death pathway, and AR-MCM7 oncogenic pathway. He proposed prostate cancer field effect in 2002. He is one of the pioneers in utilizing high throughput gene expression and genome analyses to analyze field effects in prostate cancer and liver cancer. He is also the first in using methylation array  and whole genome methylation sequencing to analyze prostate cancer. Recently, Dr. Luo’s group found that patterns of copy number variants of certain specific genome loci are predictive of prostate cancer clinical outcomes, regardless tissue origin. His discovery of several novel fusion transcripts and their association with aggressive prostate cancer has brought significant new insight into the field of prostate cancer research. Overall, these findings advance our understanding onhow cancer develops and behaves, and lay down the foundation for better future diagnosis and treatment of human malignancies.

Research Interest

Dr. Luo's research interests involve identifying new tumor suppressor genes and tumor markers in several human malignancies such as prostate cancer, hepatocellular carcinoma, etc. Subsequently, we will direct our effort to evaluate the prognostic values of these genes and markers in making early diagnosis of prostate cancer and serving as drug targets for cancer prevention programs.

Professional Activities:

1999-2000 Research Assistant Professor Department of Pathology University of Pittsburgh School of Medicine
2000- 2000 Assistant Professor Department of Pathology University of Pittsburgh School of Medicine
2000- 2005 Assistant Professor Department of Pathology University of Pittsburgh
2005- 2009 Associate Professor Department of Pathology University of Pittsburgh
2009- 2012  Associate Professor Department of Pathology University of Pittsburgh
2012- Present Professor Department of Pathology University of Pittsburgh
2000- Present Attending Pathologist anatomic pathology and anatomic molecular pathology University of Pittsburgh Medical Center, Pittsburgh, PA
2000- 2010 Director of Gene Array Laboratory Department of Pathology University of Pittsburgh
2011-Present Director of High Throughput Genome Center Department of Pathology University of Pittsburgh, PA



  1. Liu, Silvia; Tsai, Wei-Hsiang; Ding, Ying; Chen, Rui; Fang, Zhou; Huo, Zhiguang; Kim, Sung Hwan; Ma, Tianzhou; Chang, Ting-Yu; Priedigkeit, Nolan; Lee, Adrian; Luo, Jianhua; Wang, Hsei-Wei; Chung, I-Fang and Tseng, George (2015). Comprehensive evaluation of fusion transcript detection algorithms and a meta-caller to combine top performing methods in paired-end RNA-seq data. Nucleic Acids Research, in press.
  2. Adam Abeshouse, Jaeil Ahn, Rehan Akbani, Adrian Ally, Samirkumar Amin, Jianhua Luo, et al (2015). The Molecular Taxonomy of Primary Prostate Cancer. Cell 163, 1011-1025.
  3. Yan P. Yu, Silvia Liu, Zhiguang Huo, Amantha Martin, Joel B. Nelson, George C. Tseng and Jian-Hua Luo (2015). Genomic copy number variations in the genomes of leukocytes predict prostate cancer clinical outcomes. PLOS ONE, 10(8):e0135982.
  4. Wang T, Guan W, Lin J, Boutaoui N, Canino G, Luo J, Celedón JC, Chen W (2015). A systematic study of normalization methods for Infinium 450K methylation data using whole-genome bisulfite sequencing data. Epigenetics 10(7):662-9.
  5. Ze-Hua Zuo, Yan P. Yu, Ying Ding, Silvia Liu, Amantha Martin, George Tseng and Jian-Hua Luo (2015). Oncogenic activity of miRNA 650 in prostate cancer is mediated by suppression of CSR1 expression. American Journal of Pathology 185(7):1991-9.
  6. Jian-Hua Luo, Silvia Liu, Ze-Hua Zuo, Rui Chen, George C. Tseng and Yan P. Yu (2015). Discovery and classification of fusion transcripts in prostate cancer and normal prostate tissue. American Journal of Pathology 185(7):1834-45.
  7. Zhang-Hui Chen, Yan P. Yu, George Michalopoulos, Joel Nelson and Jian-Hua Luo (2015). The DNA replication licensing factor miniature chromosome maintenance 7 is essential for RNA splicing of epidermal growth factor receptor, c-met and platelet derived growth factor receptor. Journal of Biological Chemistry, 290(3):1404-11.
  8. Kelly Koral, Shirish Paranjpe, William Bowen, Wendy Mars, Jianhua Luo and George K. Michalopoulos (2015). Leukocyte Specific Protein-1: a novel regulator of hepatocellular proliferation and migration deleted in human HCC. Hepatology 61(2):537-47.
  9. Irina L. Tourkova, Michelle R. Witt, La Li,a Quitterie Larrouture, Li Liu, Jianhua Luo, Lisa J. Robinson, and Harry C. Blair (2014). Follicle Stimulating Hormone Receptor in Mesenchymal Stem Cells Integrates Effects of Glycoprotein Reproductive Hormones. Marrow-Annals of the New York Academy of Sciences, 2015 Jan;1335(1):100-9.
  10. Yan P. Yu, Ying Ding, Zhanghui Chen, Silvia Liu, Amantha Michalopoulos, Rui Chen, Zulfiqar G. Gulzar, Bing Yang, Kathleen Cieply, Alyssa Luvison, Bao-Guo Ren, James D. Brooks, David Jarrard, Joel B. Nelson, George Michalopoulos, George C. Tseng and Jian-Hua Luo (2014). Novel fusion transcripts associate with progressive prostate cancer, American Journal of Pathology, 184, 2840-9.
  11. Yan P. Yu, Amantha Martin, Ding Ying, George Tseng and Jian-Hua Luo (2014). High Fidelity Copy Number Analysis of Formalin-Fixed and Paraffin-Embedded Tissues Using Affymetrix Cytoscan HD Chip. PLOS ONE 9(4):e92820.
  12. Lindsey M. Kelly, Guillermo Barila, Pengyuan Liu, Viktoria N Evdokimova, Sumita Trivedi, Federica Panebianco, Manoj Gadhi, Sally E. Carty Steven Hodak, Jianhua Luo, Sanja Dacic, Yan P Yu, Marina N Nikiforova, Robert L. Ferris, Daniel L. Altschuler and Yuri E Nikiforov (2014). Identification of the transforming STRN-ALK fusion as a potential therapeutic target in the aggressive forms of thyroid cancer. The Proceedings of National Academy of Sciences of USA, 111(11):4233-8.
  13. Yan P. Yu, Ying Ding, Rui Chen, Serena G. Liao, Bao-Guo Ren, Amantha Michalopoulos, George Michalopoulos, Joel Nelson, George C. Tseng and Jian-Hua Luo (2013). Whole genome methylation sequencing reveals distinct impact of differential methylations on gene transcription in prostate cancer. American Journal of Pathology 183, 1960-1970.
  14. Sarah E. Gibson, Jianhua Luo, Malini Sathanoori, Jun Liao, Urvashi Surti, George K. Michalopoulos and Steven H. Swerdlow (2014). Whole Genome Single Nucleotide Polymorphism Array Analysis is Complementary to Classical Cytogenetic Analysis in the Evaluation of Lymphoid Proliferations. American Journal of Clinical Pathology 141, 247-255.
  15. Lang-Zhu Tan, Yang Song, Joel Nelson, Yan P. Yu and Jian-Hua Luo (2013). Integrin alpha 7 binds tissue inhibitor of metalloproteinase 3 to suppress growth of prostate cancer cells. American Journal of Pathology 183(3):831-40.
  16. Vishakha S. Bhave, Wendy Mars, Shashikiran Donthamsetty, Xiyue Zhang, Langzhu Tan, Jianhua Luo, William C. Bowen, and George K. Michalopoulos (2013). Regulation of liver growth by Glypican 3, CD81, Hedgehog, and Hhex. American Journal of Pathology 183(1):153-9.
  17. Jian-Hua Luo, Ying Ding, Rui Chen, George Michalopoulos, Joel Nelson, George Tseng, and Yan P. Yu (2013). Genome-wide methylation analysis of prostate tissues reveals global methylation patterns of prostate cancer. American Journal of Pathology, 182, 2028-2036.
  18. Su F, Correa BR, Luo J, Vencio RZ, Pascal LE, Wang Z (2013). Gene Expression Profiling Reveals Regulation of ERK Phosphorylation by Androgen-Induced Tumor Suppressor U19/EAF2 in the Mouse Prostate. Cancer Microenviron, 6(3):247-61.
  19. Yu-Chen Han, Zhong-Liang Zheng, Ze-Hua Zuo, Yan P. Yu, Rui Chen, George C. Tseng, Joel B. Nelson and Jian-Hua Luo (2013). Metallothionein 1h Tumor Suppressor Activity in Prostate Cancer Is Mediated By Euchromatin Methyltransferase 1. Journal of Pathology, 230, 184-93.
  20. Xi-Yue Zhang, Lang-Zhu Tang, Bao-Guo Ren, Yan P. Yu, Joel Nelson, George Michalopoulos and Jian-Hua Luo (2013). Interaction of MCM7 and RACK1 for activation of MCM7 and cell growth. American Journal of Pathology, 182:796-805.
  21. Lade A, Ranganathan S, Luo J, Monga SP (2012). Calpain induces N-terminal truncation of β-catenin in normal murine liver development: Diagnostic implications in hepatoblastomas. Journal of Biological Chemistry 287, 22789-98.
  22. Zhong-Liang Zheng, Lang-Zhu Tang, Yan P. Yu, George Michalopoulos and Jian-Hua Luo (2012). Interaction of CSR1 with XIAP reverses inhibition of caspases and accelerates cell death. American journal of Pathology, 181, 463-71.
  23. Hui Wang, Katherine Luo, Lang-Zhu Tan, Bao-Guo Ren, Li-Qun Gu, George Michalopoulos, Jian-Hua Luo, and Yan P. Yu (2012). p53-Induced-Gene 3 Mediates Cell Death Induced by Glutathione Peroxidase 3. Journal of Biological Chemistry 287, 16890-902.
  24. Yan P. Yu, Chi Song, George Tseng, Baoguo Ren, William Laframboise, George Michalopoulos, Joel Nelson and Jian-Hua Luo (2012). Genome abnormalities precede prostate cancer and predict clinical relapse. American Journal of Pathology, 180, 2240-8.
  25. Michael Nalesnik, George Tseng Ying Ding, Guo-Sheng Xiang, Zhong-liang Zheng, Yan Ping Yu, J. Wallis Marsh, George Michalopoulos and Jian-Hua Luo (2012). Gene Deletions and Amplifications in Human Hepatocellular Carcinomas: Correlation with Hepatocyte Growth Regulation. American Journal of Pathology 180, 1495-508.
  26. Shuichi Hashimoto, Hiroshi Nakano, Yuko Suguta, Seiko Irie, Luo Jianhua and Sikandar L. Katyal (2012). Exogenous FGF-10 Induces Cystic Lung Development with Altered Target Gene Expression in the Presence of Heparin in Cultures of Embryonic Rat Lung. Pathobiology 79:127–143.
  27. Fafalios A, Ma J, Tan X, Stoops J, Luo J, Defrances MC, Zarnegar R. (2011). Direct cross-talk between Hepatocyte Growth Factor Receptor (Met) and Insulin Receptor (IR) via Met-IR hybrid receptor: Implication in Hepatic Insulin Resistance and Glucose Metabolism. Nature Medicine 17, 1577-84.
  28. Yan-Ping Yu and Jian-Hua Luo (2011). Phosphorylation and interaction of Myopodin by Integrin-Link Kinase Lead to Suppression of Cell Growth and Motility in Prostate Cancer Cells. Oncogene 30, 4855-63.
  29. Kaneno R, Shurin GV, Kaneno FM, Naiditch H, Luo J, Shurin MR (2011). Chemotherapeutic agents in low noncytotoxic concentrations increase immunogenicity of human colon cancer cells. Cell Oncol, 34:97-106.
  30. Liu, Bowen; Bell, Aaron; Paranjpe, Shirish; Luo, Jian-Hua; Mar, Wendy and George Michalopoulos (2010). Suppression of Liver Regeneration and Hepatocyte Proliferation in Glypican 3 Hepatocyte-targeted Transgenic Mice. Hepatology 52, 1060-7.
  31. Ze-Hua Zhu, Yan P. Yu, Zhong-Liang Zheng, Yang Song, Guo-Sheng Xiang, Joel Nelson1, George Michalopoulos and Jian-Hua Luo (2010). Integrin alpha 7 interacts with HtrA2 to induce prostate cancer cell death. American Journal of Pathology 177, 1176-86.
  32. Yu-Chen Han, Yan P. Yu, Joel Nelson, Chuanyue Wu, Hui Wang, George K. Michalopoulos and Jian-Hua Luo (2010). Interaction of integrin linked kinase (ILK) and MCM7 mediating integrin α7 induced cell growth suppression. Cancer Research 70, 4375-4384.
  33. Luo, JH (2011). “Oncogenic activity of MCM7 transforming cluster”. World Journal of Clinical Oncology 2: 120-124.
  34. MM Cajaiba, J Luo, MA Goodman, KA Fuhrer and UNM Rao (2010). Sox9 expression is not limited to chondroid neoplasms: variable occurrence in other soft tissue and bone tumors with frequent expression by synovial sarcomas. International Journal of Surgical Pathology 18, 319-323.
  35. Yi-Kang Shi, Yan P. Yu, George C. Tseng and Jian-Hua Luo (2010). Inhibition of prostate cancer growth and metastasis using small interference RNA specific for minichromosome complex maintenance component 7. Cancer Gene Therapy 17, 694-699.
  36. Shirish Paranjpe, Bowen Liu, George C. Tseng, Jian-Hua Luo and George Michalopoulos (2010). RNA Interference against hepatic EGFR has suppressive effects on liver regeneration in rats. American Journal of Pathology 176, 2669-2681.
  37. Shashikiran Donthamsetty, William Bowen, Wendy Mars, Vishakha Bhave, Jian-Hua Luo, Cary Wu, Jennifer Hurd, Ann Orr, Aaron Bell and George Michalopoulos (2009). Liver Specific Ablation of Integrin Linked Kinase (ILK) in Mice Results in Enhanced and Prolonged Cell Proliferation and Hepatomegaly after Phenobarbital Administration. Toxicological Sciences 113, 358-366.
  38. Katherine L. Luo, Jian-Hua Luo, Yan P. Yu (2010). (-)-Epigallocatechin-3-gallate inducing cell death through down regulation of Inhibitor of DNA binding 2, a dominant negative helix-loop-helix protein. Cancer Science 10, 707-712.
  39. Chunrong Cheng, Jianhua Luo and George C. Tseng (2009). Ratio Adjustment and Calibration Scheme for Gene-wise Normalization to Enhance Microarray Inter-study Prediction. Bioinformatics 25, 1655-61.
  40. Bowen Liu, Shirish Paranjpe, William C. Bowen, Aaron W. Bell, Jian-Hua Luo, Yan-Ping Yu, Wendy M. Mars, George K. Michalopoulos (2009). Investigation of the Role of Glypican 3 in Liver Regeneration and Hepatocyte Proliferation. American Journal of Pathology 175, 717-724.
  41. Yu-Chen Han, Yan P. Yu, George C. Tseng and Jian-Hua Luo (2009). Trypsin and Reduction Method to Prepare DNA from Formalin-Fixed and Paraffin Embedded Samples for Methylation Analysis. Histopathology, 54:773-5.
  42. George C. Tseng, Chunrong Cheng, Yan Ping Yu, Joel Nelson, George Michalopoulos and Jian-Hua Luo (2009). Common Predictive Biomarkers and Cross-predictability in the Expression Profiles of Multiple Cancer Types. Biomarker Insights 4, 57-79.
  43. Apte U, Gkretsi V, Bowen WC, Mars WM, Luo JH, Donthamsetty S, Orr A, Monga SP, Wu C, Michalopoulos GK (2009). Enhanced liver regeneration following changes induced by hepatocyte-specific genetic ablation of integrin-linked kinase. Hepatology 50, 844-51.
  44. Ze-Hua Zhu, Yan P. Yu, Yi-Kang Shi, Joel B. Nelson, and Jian-Hua Luo (2009). CSR1 Inducing Cell Death through Inactivation of CPSF3. Oncogene 28:41-51.
  45. Yi-Kang Shi, Yan P. Yu, Ze-Hua Zhu, Yu-Chen Han, Baoguo Ren, Joel B. Nelson and Jian-Hua Luo (2008). MCM7 Interacting With Androgen Receptor. American Journal of Pathology, 173:1758-67.
  46. Vasiliki Gkretsi, Udayan Apte, Wendy M. Mars, William C. Bowen1, Jian-Hua Luo, Yu Yang,Yan P.Yu, Ann Orr, René St.-Arnaud, Shoukat Dedhar, Klaus H. Kaestner, Chuanyue Wu and George K. Michalopoulos (2008). Liver specific ablation of integrin linked kinase in mice results in abnormal histology, enhanced cell proliferation and hepatomegaly. Hepatology 48:1932-41.
  47. Chiosea S., Acquafondata M., Luo J., Kuan SF. and Seethala RR.  (2008). DICER1 and PRKRA in Colon Adenocarcinoma. Biomarker Insights, 3, 253-258.
  48. Limaye P, Bowen W, Luo J-H, Tseng GC and Michalopoulos G (2008). Mechanisms of HGF and EGF mediated signaling in transdifferentiation of rat hepatocytes to biliary epithelium. Hepatology 47, 1702-13.
  49. Yan P. Yu, Guoying Yu, George Tseng, Kathleen Cieply, Joel Nelson, Marie Defrances, Reza Zarnegar, George Michalopoulos and Jian-Hua Luo (2007). Glutathione Peroxidase 3, Deleted or Methylated In Prostate Cancer, Suppresses Prostate Cancer Growth and Metastasis. Cancer Research 67, 8043-8050.
  50. Baoguo Ren, Yan P. Yu, George C. Tseng, Chuanyue Wu, Ka Chen, Uma N. Rao, Joel Nelson, George K. Michalopoulos and Jian-Hua Luo (2007). Analysis of Integrin α7 Mutations in Prostate Cancer, Liver Cancer, Glioblastoma Multiforme, and Leiomyosarcoma. Journal of National Cancer Institute 99, 868-880.
  51. Craig, F.E., Johnson, L.R., Harvey, S.A.K., Nalesnik, M.A., Luo, J.H., Bhattacharya, S.D., and Swerdlow, S.H. (2007). Gene Expression Profiling of Epstain-Bar Virus-Positive and Negative Monomorphic B-Cell Post-transplant Lymphoproliferative Disorders. Diagnostic Molecular Pathology 16, 158-168.
  52. Shirish Paranjpe, William C. Bowen, Aaron W. Bell, Kari Nejak-Bowen, Jian-Hua Luo and George K. Michalopoulos (2007). Cell cycle effects caused by inhibition of HGF and its receptor c-met in regenerating rat livers by RNA interference. Hepatology 45, 1471-1477.
  53. Chiosea S, Jelezcova E, Chandran U, Luo J, Mantha G, Sobol RW, Dacic S. (2007). Overexpression of Dicer in precursor lesions of lung adenocarcinoma. Cancer Res. 67(5):2345-50.
  54. Yu, Y.P. and Luo, J.H. (2007). Pathology factors to evaluate prostate cancer. Histology and histopathology 22, 1291-300.
  55. Yingjian Li, Junwei Yang, Jian-Hua Luo, Shoukat Dedhar and Youhua Liu (2007). Tubular epithelial cells dedifferentiation is driven by helix-loop-helix transcriptional inhibitor Id1. Journal of the American Society of Nephrology 18, 449-60.
  56. Jian-Hua Luo, Baoguo Ren, Sergei Keryanov, George C. Tseng, Uma N.M. Rao, Satdarshan P. Monga,  Steven Strom, Anthony J. Demetris, Michael Nalesnik, Yan P. Yu, Sarangarajan  Ranganathan and George K. Michalopoulos (2006). Transcriptomic and Genomic analysis of Human Hepatocellular Carcinomas and Hepatoblastomas. Hepatology 44, 1012-1024.
  57. Yan Ping Yu and Jian-Hua Luo (2006). Myopodin Mediated Suppression of Prostate Cancer Cell Migration Involves Interaction with Zyxin. Cancer Research, 66, 7414-7419.
  58. Yan Ping Yu, George C. Tseng and Jian-Hua Luo (2006). Inactivation of Myopodin Expression Is Associated with Prostate Cancer Relapse. Urology 68, 578-82.
  59. Guoying Yu, George C. Tseng, Yan Ping Yu, Tim Gavel, Joel Nelson, Alan Wells, George Michalopoulos, Demetrius Kokkinakis and Jian-Hua Luo (2006). CSR1 Suppresses Tumor Growth and Metastasis of Prostate Cancer. American Journal of Pathology 168, 597-607.
  60. Baoguo Ren, Guoying Yu, George C. Tseng, Kathleen Cieply, Timothy Gavel, Joel Nelson, George Michalopoulos, Yan Ping Yu and Jian-Hua Luo (2006). MCM7 Amplification and Overexpression Are Associated with Prostate Cancer Progression. Oncogene 25, 1090-1098.
  61. Monga SP, Hout MS, Baun MJ, Micsenyi A, Muller P, Tummalapalli L, Ranade AR, Luo JH, Strom SC, Gerlach JC (2005). Mouse fetal liver cells in artificial capillary beds in three-dimensional four-compartment bioreactors. American Journal of Pathology 167:1279-92.
  62. Xinping Tan, Udayan Apte, Amanda Micsenyi, Emorphia Kotsagrelos, Jian-Hua Luo, Sarangarajan Ranganathan, Dulabh K. Monga, Aaron Bell, George K. Michalopoulos, Satdarshan P.S. Monga (2005). EGFR: A novel target of the WNT/BETA-catenin pathway in liver. Gastroenterology 129, 285-302.
  63. Yan Ping Yu, Shirish Paranjpe, Joel Nelson, Sydney Finkelstein, Baoguo Ren, Demetrius Kokkinakis, George Michalopoulos and Jian-Hua Luo (2005). High throughput Screening of Methylation Status of Genes in Prostate Cancer Using Oligonucleotide Methylation Array. Carcinogenesis 26, 471-479.
  64. Yan Ping Yu, Douglas Landsittel, Ling Jing, Joel Nelson, Baoguo Ren, Lijun Liu, Courtney McDonald, Ryan Thomas, Rajiv Dhir, Sydney Finkelstein, George Michalopoulos, Michael Becich, and Jian-Hua Luo (2004). Gene Expression Alterations in Prostate Cancer Predicting Tumor Aggression and Preceding Development of Malignancy. Journal of Clinical Oncology 22, 2790-2799.
  65. Ling Jing, Lijun Liu, Yan Ping Yu, Rajiv Dhir, Marie Acquafondada, Doug Landsittel++. Kathleen Cieply, Alan Wells, and Jian-Hua Luo (2004).  Expression of Myopodin Induces Suppression of Tumor Growth and Metastasis. Am. J. of Path. 164, 1799-1806.
  66. Demetrius M. Kokkinakis, Elisabeth Rushin, Mark Watson, Shuttin Yang , Ujjal K. Singha  and Jianhua  Luo  (2004).  Physiology and gene expression characteristics of carcinogen initiated and tumor transformed glial progenitor cells derived from the CNS of methylnitrosourea (MNU) treated Sprague Dawley rats. Journal of Neuropathology and Experimental Neurology 63, 1182-1199.
  67. Guzey M, Luo J, Getzenberg RH.(2004). Vitamin D(3) modulated gene expression patterns in human primary normal and cancer prostate cells. J Cell Biochem. 93, 271-285.
  68. Demetrius M. Kokkinakis, Xiayan Liu,  Sunil Chada, Mansoor M. Ahmed, Mohammed M. Shareef,  Sutin Yang,  Ujjal K. Singha and Jianhua Luo (2004).  Modulation of gene expression in human CNS tumors under methionine deprivation induced stress. Cancer Research 64, 7513-7525.
  69. Micsenyi, A., Tan, X., Sneddon, T., Luo, J.H., Michalopoulos, G.K., Monga, S.P. (2004). Beta-Catenin is temporally regulated during normal liver development. Gastroenterology 126, 1134-1146.
  70. Asmaa Mamoune, Jian-Hua Luo, Douglas A Lauffenburger and Alan Wells (2003). m-Calpain as a target for limiting prostate cancer invasion. Cancer Res. 63, 4632-4640.
  71. Michalopoulos, G.K., W.C. Bowen, K. Mulè and J-H Luo (2003). HGF, EGF and Dexamethasone regulation of gene expression patterns during formation of tissue in hepatic organoid cultures. Gene Expression 11, 55-75.
  72. Ren, B, Y.P. Yu, L. Jing, L. Liu, G. Michalopoulos, J-H Luo and U. Rao (2003). Gene Expression Analysis of Human Soft Tissue Leiomyosarcoma. Human Path. 34, 549-558.
  73. Luo, J.H. and Yu, Y.P. (2003) Genetic Factors Underlying Prostate Cancer. Molecular Medicine. 5:1-26.
  74. Luo, J.H., Y.P. Yu, K. Cieply, F. Lin, P. Deflavia, R. Dhir, S. Finkelstein, G. Michalopoulos, M. Becich (2002). Gene Expression Analysis of Prostate Cancers. Molecular Carcinogenesis, 33, 25-35.
  75. Lin, F., Y. P. Yu, J.Woods, K. Cieply, W. Gooding, P. Finkelstein, R. Dhir, D. Krill, M. J. Becich, G Michalopoulos, S. Finkelstein and J-H Luo (2001). Myopodin, a novel synaptopodin homologue, is frequently deleted in invasive prostate cancers. Am. J. Path., 159, 1603-1612.
  76. Krill D, DeFlavia P, Dhir R, Luo J, Becich MJ, Lehman E, Getzenberg RH. (2001). Expression Pattern of Vitamin D Receptor in Human Prostate. J. Cell. Biochem.82, 566-72.
  77. Yu, Y.P.,  F. Lin, R. Dhir, D. Krill, M. Becich and J.H. Luo (2001). Linear Amplification of Gene Specific cDNA Ends to Isolate Full Length of a cDNA. Analytical Biochem. 292, 297-301.
  78. Yu, Y.P., F. Lin, M. Bisceglia, D. Krill, R. Dhir, M. Becich and J.H. Luo (2001). Identification of a Novel Gene with Increasing Rate of Suppression in High Grade Prostate Cancers. Am. J. Path, 158, 19-24.
  79. Luo, J.H., J.A. Puc, E.D. Slosberg, Y. Yao, J.N. Bruce, T.C. Wright, M.J. Becich, R. Parsons (1999). Differential Subtraction Chain, A Method for Identifying Differences in  Genomic DNA and mRNA. Nucleic Acids Res, 27, 24e, i-viii.
  80. Luo, J.H., Matsushima, A.Y., Chen, R., and Szabolcs,  M. (1998). Detection of CD5 antigen on B cell lymphomas in fixed, paraffin embedded tissues using signal amplification by catalyzed reporter deposition. Eur. J. Histochem. 42(1):31-9.
  81. Luo, J.H., and H. Rotterdam (1997). Primary amyloid tumor of the breast: a case report and review of the literature. Mod. Pathol. 10(7):735-8.
  82. Smith, C.C., J.H. Luo, and L. Aurelian (1996). The protein kinase activity of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) fused to the extracellular domain of the epidermal growth factor receptor is ligand-inducible. Virology 217(2):425-34.
  83. Luo, J.H., W.Q. Xing, and I.B. Weinstein (1995). The phorbol ester TPA markedly enhances the binding of calcium to the regulatory domain of protein kinase Cβ1 in the presence of phosphatidylserine. Carcinogenesis 16, 897-905.
  84. Ron, D., J.H. Luo, D. Mochly-Rosen (1995). C2 Region-derived Peptides Inhibit Translocation and Function of  Protein Kinase C in Vivo. J Biol Chem. 270, 24180-7.
  85. Smith, C.C.*, Luo, J.H.*, J.C. Hunter, J.V. Ordonez, and L. Aurelian (1994). The transmembrane domain of the large subunit of HSV-2 ribonucleotide reductase (ICP10) is required for protein kinase activity and transformation-related signaling pathways that result in ras activation. Virology 200, 598-612. (* - the first two authors contributed equally)
  86. Luo, J.H. and I.B. Weinstein (1993). Calcium-dependent activation of protein kinase C: the role of the C2 domain in divalent cation selectivity. J. Biol.Chem. 268: 23580-23584.
  87. Luo, J.H., S. Kahn, K. O'Driscoll, and I. B. Weinstein (1993). The regulatory domain of protein kinase C β1 contains phosphatidylserine- and phorbol ester- dependent calcium binding activity. J. Biol.Chem. 268, 3715-3719.
  88. Luo, J.H. and L. Aurelian (1992). The transmembrane helical segment but not the invariant Lys is required for the kinase activity of the large subunit of herpes simplex virus type 2 ribonucleotide reductase. J. Biol.Chem. 267, 9645-9653.
  89. Wachsman, M., J.H. Luo, L. Aurelian, K. Hepper, M.E. Perkus and E. Paoletti (1992). Protection from herpes simplex virus type 2 (HSV-2) with a vaccinia recombinant virus expressing HSV glycoprotein D is associated with T cells involved in delayed type hypersensitivity. Vaccine 10, 447-454.
  90. Luo, J.H., C.C. Smith, M. Kulka, L. Aurelian (1991). A truncated protein kinase domain of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) expressed in Escherichia Coli. J. Biol. Chem. 266, 20976-20983.
  91. Chung, T., J.H. Luo, J.P. Wymer and L. Aurelian (1991). Leucine repeats in the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) is involved in RR activity and subunit complex formation. J. of General Virology 72, 1139-1144.
  92. Smith, C.C., J.P. Wymer, J.H. Luo, and L. Aurelian (1991). Genomic sequences homologous to the protein kinase region of the bifunctional herpes simplex virus type 2 protein ICP10. Virus Genes 5, 215-226.
  93. Wachsman, M., J.H. Luo, L. Aurelian, M.E. Perkus and E. Paoletti (1989).  Antigen-presenting capacity of epidermal cells infected with vaccinia virus recombinants containing the herpes simplex virus glycoprotein D, and protective immunity. J. General Virology 70, 2513-2520.


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