Education

Biography

Jack L Arbiser is a Thomas J. Lawley Professor of Dermatology and at Winship Cancer Institute, Emory University School of Medicine, Atlanta, USA. Board certified in dermatology, Jack Arbiser, MD, PhD, started practicing at Emory Healthcare in 1998. His clinical specialties include lichen planus, melanoma and skin cancer.

Dr. Arbiser is a member of the Discovery and Developmental Therapeutics research program at Winship Cancer Institute of Emory University. He also holds memberships in the American Academy of Dermatology and the Society of Investigative Dermatology.

Research Interest

Dermatology, Lichen planus, Melanoma and Skin cancer.

Scientific Activities:

Teaching and Experience

Professional Organizations

Honors & Awards:

Publications

1. Liotta D, Arbiser JL, Short JW, Saindane M. 1983. A simple inexpensive procedure for the large-scale production of alkyl quinones. Journal of Organic Chemistry, 48(17): 2932-2933.
2. Schinazi RF, Arbiser JL, Lee JJ, Kalman TI, Prusoff WH. 1986. Synthesis and biologic activity of 5-phenylselenenyl-substituted pyrimidine nucleosides. Journal of Medicinal Chemistry, 29(7): 1293-1295.
3. Arbiser JL, Morton CC, Bruns GA, Majzoub JA. 1988. Human corticotropin releasing hormone gene is located on the long arm of chromosome 8. Cytogenetics and Cell Genetics, 47(3): 113-116.
4. Robinson BG, Arbiser JL, Emanuel R, Majzoub JA. 1989. Species-specific placental corticotropin releasing hormone mRNA and peptide expression. Molecular and Cellular Endocrinology, 62(2): 337-341.
5. Arbiser JL, Arbiser ZK, Majzoub JA. 1991. Regulation of gene expression in choriocarcinoma by methotrexate and hydroxyurea. Endocrinology, 128(2): 972- 978.
6. Arbiser JL, Arbiser ZK, Majzoub JA. 1993. Effects of hydroxyurea and cyclic adenosine monophosphate/protein kinase A inhibitors on the expression of the human chorionic gonadotropin alpha subunit and c-myc genes in choriocarcinoma. Journal of Endocrine Investigation, 16(11): 849-856.
7. Arbiser JL, Arbiser ZK, Majzoub JA. 1993. Differential regulation of choriocarcinoma gene expression by DNA synthesis inhibitors. Endocrine Journal, 40(2): 263-268.
8. Goldring MB, Birkhead JR, Suen LF, Yamin R, Mizuno S, Glowacki J, Arbiser JL, Apperley JF. 1994. Interleukin 1b modulated gene expression in immortalized human chondrocytes. Journal of Clinical Investigation, 94(6): 2307-2316.
9. Van Leeuwen RL, Dekker SK, Arbiser JL, Vermeer BJ, Bruijn JA, Byers HR. 1994. Phorbol ester induced rapid attachment and spreading of melanoma cells and the role of extracellular matrix proteins. International Journal of Cancer, 57(6): 894-900.
10. Arbiser JL, Martinez C, Arbiser ZK, Rosen LB, Adler GK, Majzoub JA. 1994. Regulation of the ectopically expressed human glycoprotein alpha-subunit gene in the human hepatoma cell line NPLC. Endocrinology, 134(2): 582-587.
11. Arbiser JL, Alani R, Wooten W, Flynn E, Byers HR. 1997. Effects of thallium ion on cellular components of the skin. Journal of Dermatology, 24(3): 147-155.
12. Arbiser JL, Moses MA, Fernandez CA, Ghiso N, Cao Y, Klauber N, Frank D, Brownlee M, Flynn E, Parangi S, Byers HR, Folkman J. 1997. Oncogenic H-Ras stimulates tumor angiogenesis by two distinct pathways. Proceedings of the National Academy of Sciences, 94(3): 861-866.
13. Arbiser JL, Fine JD, Murrell D, Paller A, Connors S, Keough K, Marsh E, Folkman J. 1998. Basic fibroblast growth factor: A missing link between collagen VII, increased collagnease, and squamous cell carcinoma in recessive dystrophic epidermolysis bullosa. Molecular Medicine, 4(3): 191-195.
14. Arbiser JL, Klauber N, Rohan R, van Leeuwen R, Huang MT, Fisher C, Flynn E, Byers HR. 1998. Curcumin is an in vivo inhibitor of angiogenesis. Molecular Medicine, 4(6): 376-383.
15. Holmgren L, Jackson G, Arbiser JL. 1998. p53 induces angiogenesis restricted dormancy in a mouse fibrosarcoma. Oncogene, 17(7): 819-824.
16. Arbiser JL, Flynn E, Barnhill R. 1998. Analysis of vascularity in neurofibromas. Journal of the American Academy of Dermatology, 38: 950-954.
17. Arbiser JL, Kraefft S, van Leeuwen R, Hurwitz S, Dickersin GR, Selig M, Byers HR, Chen LB. 1998. Clioquinol-zinc chelate is a candidate causative agent for subacute myelo-optic neuropathy (SMON). Molecular Medicine, 4(10): 665-670.
18. Arbiser JL, Panigrathy D, Klauber N, Rupnick M, Flynn E, Udagawa T, D’Amato RJ. 1999. The antiangiogenic agents TNP-470 and 2-methoxyestradiol inhibit growth of angiosarcoma in mice. Journal of the American Academy of Dermatology, 40: 925-929.
19. Arbiser JL, Raab G, Rohan RM, Paul S, Hirschi K, Flynn E, Price ER, Fisher DE, Cohen C, Klagsbrun M. 1999. Isolation of mouse stromal cells associated with a human tumor using differential diptheria toxin sensitivity. American Journal of Pathology, 155(3): 723-729.
20. Arbiser JL, Karalis K, Viswanathan A, Koike C, Anand-Apte B, Flynn F, Zetter BR, Majzoub JA. 1999. Corticotropin releasing hormone stimulates angiogenesis and epithelial tumor growth in the skin. Journal of Investigative Dermatology, 113(5): 838-842.
21. Wen W, Moses MA, Wiederschain D, Arbiser JL, Folkman J. 1999. The generation of endostatin is mediated by elastase. Cancer Research, 59(24): 6052- 6056.
22. Arbiser JL, Larsson H, Claesson-Welsh L, Bai X, LaMontagne K, Weiss SW, Soker S, Flynn E, Brown LF. 2000. Overexpression of VEGF 121 in immortalized endothelial cells causes conversion to slowly growing angiosarcoma and high level expression of the VEGF receptors VEGFR-1 and VEGFR-2 in vivo. American Journal of Pathology, 156(14): 1469-1476.
23. McLaughlin ER, Brown LF, Weiss SW, Mulliken JB, Perez-Atayde A, Arbiser JL. 2000. VEGF and its receptors are expressed in a pediatric angiosarcoma in a patient with Aicardi’s syndrome. Journal of Investigative Dermatology, 114:1209-1210.
24. Arbiser JL, Byers HR, Cohen C, Arbeit J. 2000. Altered basic fibroblast growth factor expression in common epidermal neoplasms: examination using in situ hybridization and immunohistochemistry. Journal of the American Academy of Dermatology, 42(6): 973-977.
25. Shaw RN, Arbiser JL, Offerman MK. 2000. Valproic acid induces HHV8 lytic gene expression in BCBL-1 cells. AIDS, 14: 899-902.
26. Robbins JR, Thomas B, Tan L, Choy B, Arbiser JL, Berenbaum F, Goldring MB. 2000. Immortalized human adult articular chondrocytes maintain cartilage- specific phenotype and responses to interleukin-1β. Arthritis & Rheumatism, 43(10): 2189-2201.
27. LaMontagne Jr KR, Moses MA, Wiederschain D, Mahajan S, Holden J, Ghazizadeh H, Frank DA, Arbiser JL. 2000. Inhibition of MAP kinase kinase causes morphologic reversion and dissociation between soft agar growth and in vivo tumorigenesis in angiosarcoma cells. American Journal of Pathology, 157(6): 1937-1945.
28. Arbiser JL, Yeung R, Weiss SW, Arbiser ZK, Amin MB, Cohen C, Frank D, Mahajan S, Herron GS, Yang J, Onda H, Zhang HB, Bai X, Uhlmann E, Loehr A, Northrup H, Au P, Davis I, Fisher DE, Gutmann DH. 2001. The generation and characterization of a cell line derived from a sporadic renal angiomyolipoma: use of telomerase to obtain stable populations of cells from benign neoplasms. American Journal of Pathology, 159(2): 483-491.
29. Arbiser JL, Weiss SW, Arbiser ZK, Bravo F, Govindarajan B, Caceres-Rios H, Cotsonis G, Recavarren S, Swerlick RA, Cohen C. 2001. Differential expression of active MAP kinase in cutaneous endothelial neoplasms: implications for biologic behavior and response to therapy. Journal of the American Academy of Dermatology, 44(2): 193-197.
30. O’Reilly FM, Brat DJ, McAlpine B, Grossniklaus HE, Folpe AL, Arbiser JL. 2001. Microphthalmia transcription factor immunohistochemistry: a useful diagnostic marker in the diagnosis and detection of cutaneous melanoma, sentinel lymph node metastases, and extracutaneous melanocytic neoplasms. Journal of the American Academy of Dermatology, 45(3): 414-419.
31. Kim A, DiCarlo J, Cohen C, McCall C, Johnson D, McAlpine B, Quinn AG, McLaughlin ER, Arbiser JL. 2001. Are keloids really “gli-loids”? High-level expression of gli-1 oncogene in keloids. Journal of the American Academy of Dermatology, 45(5): 707-711.
32. Arbiser JL , Petros J, Klafter R, Govindarajan B, McLaughlin ER, Brown LF, Cohen C, Moses M, Kilroy S, Arnold RS, Lambeth JD. 2002. Reactive oxygen generated by Nox 1 triggers the angiogenic switch. Proceedings of the National Academy of Sciences USA, 99(2): 715-720.
33. Arbiser ZK, Arbiser JL, Cohen C, Gal AA. 2001. Neuroendocrine lung tumors: grade correlates with proliferation but not angiogenesis. Modern Pathology, 14(12): 1195-1199.
34. Arbiser JL, Brat DJ, Hunter S, D’Armiento J, Henske EP, Arbiser ZK, Bai X, Goldberg G , Cohen C, Weiss SW. 2002. Tuberous sclerosis-associated lesions of the kidney, brain and skin are angiogenic neoplasms. Journal of the American Academy of Dermatology, 46(3): 376-380.
35. Tang T, Arbiser JL, Brandt SJ. 2002. Phosphorylation by mitogen-activated protein kinase mediates the hypoxia-induced turnover of the TAL1/SCL transcription factor in endothelial cells. Journal of Biological Chemistry, 277(21): 18365-18372.
36. Govindarajan B, Klafter R, Miller MS, Mansur C, Mizesko M, Bai X, LaMontagne Jr K, Arbiser JL. 2002. Reactive oxygen-induced carcinogenesis causes hypermethylation of p16 (Ink4a) and activation of MAP kinase. Molecular Medicine, 8(1): 1-8 (Cover issue).
37. Arbiser JL, Govindarajan B, Bai X, Onda H, Kazlauskas A, Lim SD, Amin MB, Claesson-Welsh L. 2002. Functional tyrosine kinase inhibitor profiling: a generally applicable method points to a novel role of platelet derived growth factor receptor beta (PDGFR-β) in tuberous sclerosis. American Journal of Pathology, 161(3): 781-786.
38. Arbiser JL, Bingaman A, Durham M, Cowan S, Cohen C, Zarnegar E, Varma V, Larsen CP. 2002. SVR angiosarcomas can be rejected by CD4 co-stimulation dependent and CD8 co-stimulation independent pathways. Molecular Medicine, 8(9): 551-558.
39. Cohen C, Zavala-Pompa A, Sequeira JH, Shoji M, Sexton DG, Cotsonis G, Cerimele F, Govindarajan B, Macaron N, Arbiser JL. 2002. MAP kinase activation is an early event in melanoma progression. Clinical Cancer Research, 8(12): 3728-3733.
40. Govindarajan B, Bai X, Cohen C, Zhong H, Kilroy S, Moses M, Arbiser JL. 2003. Malignant transformation of melanocytes to melanoma by constitutive activation of MAP kinase kinase signaling. Journal of Biological Chemistry, 278(11): 9790-9795.
41. Macaron NC, Cohen C, Chen SC, Arbiser JL. 2003. Cutaneous lesions of secondary syphilis are highly angiogenic. Journal of the American Academy of Dermatology, 48(6): 878-881.
42. Govindarajan B, Mizesko MC, Miller MS, Onda H, Nunnelley M, Casper K, Brat D, Cohen C, Arbiser JL. 2003. Tuberous sclerosis-associated neoplasms express activated p42/44 MAP kinase, and inhibition of MAP kinase signaling results in decreased in vivo tumor growth. Clinical Cancer Research, 9(9): 3469-3475.
43. Robinson TP, Ehlers T, Hubbard RB, Bai X, Arbiser JL, Goldsmith DJ, Bowen JP. 2003. Design, synthesis and biological evaluation of angiogenesis inhibitors: aromatic enone and dienone derivatives of curcumin. Bioorganic & Medicinal Chemistry Letters, 13(1): 115-117.
44. Bai X, Cerimele F, Ushio-Fukai M, Waqas M, Campbell PM, Govindarajan B, Der CJ, Battle T, Frank DA, Ye K, Murad E, Dubiel W, Soff G, Arbiser JL. 2003. Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. Journal of Biological Chemistry, 278(37): 35501-35507.
45. Cerimele F, Brown LF, Bravo B, Ihler GM, Kouadio P, Arbiser JL. 2003. Infectious angiogenesis: Bartonella bacilliformis infection results in endothelial production of angiopoetin-2 and epidermal production of vascular endothelial growth factor. American Journal of Pathology, 163(4): 1321-1327.
46. Rennel E, Cross MJ, Klint P, Bai X, Arbiser JL, Gerwins P. 2003. Regulation of endothelial cell differentiation and transformation by H-Ras. Experimental Cell Research, 291(1): 189-200.
47. Levchenko T, Bratt A, Arbiser JL, Holmgren L. 2004. Angiomotin expression promotes hemangioendothelioma invasion. Oncogene, 23(7): 1469-1473.
48. Gira AK, Brown LF, Washington CV, Cohen C, Arbiser JL. 2004. Keloids demonstrate high level epidermal expression of vascular endothelial growth factor. Journal of the American Academy of Dermatology, 50(6): 850-853.
49. Arbiser JL, Fan CY, Su X, Van Emburgh BO, Cerimele F, Miller MS, Harvell J, Marinkovich MP. 2004. Involvement of p53 and p16 tumor suppressor genes in recessive dystrophic epidermolysis bullosa-associated squamous cell carcinoma. Journal of Investigative Dermatology, 123(4): 788-790.
50. Lu X, Arbiser JL, West J, Hoedt-Miller M, Sheridan A, Govindarajan B, Harral JW, Rodman DM, Fouty B. 2004. Tumor necrosis factor-related apoptosis- inducing ligand can induce apoptosis in subsets of premalignant cells. American Journal of Pathology, 165(5): 1613-1620.